Shiga Kazuyoshi 志賀一慶

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shiga kazuyoshi 志賀一慶

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Researcher Number	20747282
Other IDs
Affiliation (Current)	2025: 名古屋市立大学, 医薬学総合研究院(医学), 講師
Affiliation (based on the past Project Information) *help	2019 – 2023: 名古屋市立大学, 医薬学総合研究院(医学), 助教 2017 – 2018: 名古屋市立大学, 大学院医学研究科, 助教 2016: 名古屋市立大学, 大学院医学研究科, 臨床研究医
Review Section/Research Field	Principal Investigator Basic Section 55020:Digestive surgery-related Except Principal Investigator Basic Section 55020:Digestive surgery-related / Basic Section 50010:Tumor biology-related / Digestive surgery
Keywords	Principal Investigator 癌周囲微小環境 / 薬剤耐性化 / 炎症性サイトカイン / 癌間質相互作用 / サイトカイン / 浸潤能 / 薬剤耐性 / 血管新生 / 癌浸潤 / 癌増殖 / 癌関連線維芽細胞 / 大腸癌 … More Except Principal Investigator … More 大腸癌 / CAF / 癌関連線維芽細胞 / 血管新生 / 腫瘍増殖 / 侵襲 / 腫瘍周囲の炎症変化 / 腫瘍増殖能の変化 / 炎症 / 腫瘍増殖能 / Chitinase3-like1 / CHI3L1 / Chitinase 3-like 1 / 薬剤耐性 / MCP-1 / 血管新生因子 / 癌間質相互作用 / PlGF / ERK / ERK1/2 / IL-6 / bevacizumab Less

Elucidation of the mechanism of colorectal cancer progression mediated by cancer-associated fibroblasts and Chitinase 3-like 1
- Principal Investigator
  
  Kaori Watanabe
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Nagoya City University
Oncological Impact Resulting from Cutting into Colorectal Cancer and Its Clinical Application
- Principal Investigator
  
  Ushigome Hajime
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Nagoya City University
Overcoming acquisition of anti-angiogenic drug resistance by cancer stromal cell-derived MCP-1
- Principal Investigator
  
  Hara Masayasu
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Nagoya City University
Elucidation of the mechanism of drug resistance in colorectal cancer focusing on the peri-tumour microenvironment and its application to treatmentPrincipal Investigator
- Principal Investigator
  
  shiga kazuyoshi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Nagoya City University
Antitumor effect by signal inhibition in cancer-related fibroblasts
- Principal Investigator
  
  HARA MASAYASU
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Nagoya City University

All 2022 2021 2019 2018 2017 2016

All Journal Article Presentation

[Journal Article] Chitinase 3-like 1 secreted from cancer-associated fibroblasts promotes tumor angiogenesis via interleukin-8 secretion in colorectal cancer2022
- Author(s)
  Watanabe Kaori、Shiga Kazuyoshi、Maeda Anri、Harata Shinnosuke、Yanagita Takeshi、Suzuki Takuya、Ushigome Hajime、Maeda Yuzo、Hirokawa Takahisa、Ogawa Ryo、Hara Masayasu、Takahashi Hiroki、Matsuo Yoichi、Mitsui Akira、Kimura Masahiro、Takiguchi Shuji
- Journal Title
  
  International Journal of Oncology
  
  Volume: 60 Issue: 1 Pages: 3-3
- DOI
  10.3892/ijo.2021.5293
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08716
[Journal Article] Eicosapentaenoic acid suppresses angiogenesis via reducing secretion of IL-6 and VEGF from colon cancer associated fibroblasts2019
- Author(s)
  Ando Nanako、Hara Masayasu、Shiga Kazuyoshi、Yanagita Takeshi、Takasu Korehito、Nakai Nozomu、Maeda Yuzo、Hirokawa Takahisa、Takahashi Hiroki、Ishiguro Hideyuki、Matsuo Yoichi、Takiguchi Shuji
- Journal Title
  
  Oncology Reports
  
  Volume: 印刷中 Pages: 339-349
- DOI
  10.3892/or.2019.7141
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10644, KAKENHI-PROJECT-18K16371, KAKENHI-PROJECT-16K10547
[Journal Article] Apigenin induces apoptosis by suppressing Bcl-xl and Mcl-1 simultaneously via signal transducer and activator of transcription 3 signaling in colon cancer2018
- Author(s)
  Maeda Yuzo、Takahashi Hiroki、Nakai Nozomu、Yanagita Takeshi、Ando Nanako、Okubo Tomotaka、Saito Kenta、Shiga Kazuyoshi、Hirokawa Takahisa、Hara Masayasu、Ishiguro Hideyuki、Matsuo Yoichi、Takiguchi Shuji
- Journal Title
  
  International Journal of Oncology
  
  Volume: 印刷中 Pages: 1661-1673
- DOI
  10.3892/ijo.2018.4308
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10644, KAKENHI-PROJECT-16K10547, KAKENHI-PROJECT-16K10606
[Journal Article] High serum levels of interleukin-6 in patients with advanced or metastatic colorectal cancer: The effect on the outcome and the response to chemotherapy plus bevacizumab.2016
- Author(s)
  Hara M, Nagasaki T, Shiga K, Takahashi H, Takeyama H.
- Journal Title
  
  Surg Today
  
  Volume: 47 Issue: 4 Pages: 483-489
- DOI
  10.1007/s00595-016-1404-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10547, KAKENHI-PROJECT-17K10644
[Presentation] 癌関連線維芽細胞によるChitinase 3-like 1とIL-8が関与した大腸癌血管新生メカニズム2022
- Author(s)
  渡部かをり，志賀一慶，前田杏梨，原田真之資，鈴木卓弥，前田祐三，小川了，高橋広城，松尾洋一，瀧口修司
- Organizer
  第77回日本消化器外科学会総会
- Data Source
  KAKENHI-PROJECT-21K08716
[Presentation] 大腸癌微小環境におけるChitinase 3-like 1が関与した癌血管新生メカニズムの解明2022
- Author(s)
  渡部かをり，志賀一慶，前田杏梨，原田真之資，柳田剛，鈴木卓弥，牛込創，前田祐三，小川了，高橋広城，松尾洋一，瀧口修司
- Organizer
  第122回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-21K08716
[Presentation] CAF由来Chitinase 3-like 1が大腸癌の血管新生に及ぼす影響2021
- Author(s)
  渡部かをり、志賀一慶、前田杏梨、鈴木卓弥、前田祐三、廣川高久、高橋広城、小川了、松尾洋一、瀧口修司
- Organizer
  第76回日本消化器外科学会総会
- Data Source
  KAKENHI-PROJECT-21K08716
[Presentation] 炎症性サイトカインIL-6は大腸癌の予後予測因子となり得るか？2021
- Author(s)
  志賀一慶
- Organizer
  消化器外科学会
- Data Source
  KAKENHI-PROJECT-18K16371
[Presentation] 癌関連線維芽細胞によるChitinase 3-like 1の大腸癌血管新生に対する効果2021
- Author(s)
  渡部かをり、志賀一慶、大場杏梨、原田真之資、柳田剛、鈴木卓弥、牛込創、前田祐三、小川了、高橋広城、松尾洋一、瀧口修司
- Organizer
  第27回外科侵襲とサイトカイン研究会
- Data Source
  KAKENHI-PROJECT-21K08716
[Presentation] 癌関連線維芽細胞によるChitinase 3-like 1が関与した大腸癌進展メカニズムの解明2021
- Author(s)
  渡部かをり、志賀一慶、大場杏梨、柳田剛、鈴木卓弥、牛込創、前田祐三、廣川高久、小川了、高橋広城、松尾洋一、瀧口修司
- Organizer
  第121回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-21K08716
[Presentation] In vitroにおけるcolon cancer-associated fibroblastから産生されるIL-6とVEGFに対するEPAの抑制効果とそれに伴う血管新生抑制2018
- Author(s)
  安藤菜奈子，原　賢康，志賀一慶，柳田　剛，仲井　希，前田祐三，廣川高久，高橋広城，石黒秀行，松尾洋一，瀧口修司
- Organizer
  第26回日本消化器関連学会週間
- Data Source
  KAKENHI-PROJECT-18K16371
[Presentation] In vitroにおけるcolon cancer-associated fibroblastから産生されるIL-6とVEGFに対するEPAの抑制効果とそれに伴う血管新生抑制2018
- Author(s)
  安藤菜奈子，原賢康，志賀一慶，柳田剛，仲井希，前田祐三，廣川高久，高橋広城，石黒秀行，松尾洋一，瀧口修司
- Organizer
  第26回日本消化器関連学会週間
- Data Source
  KAKENHI-PROJECT-16K10547
[Presentation] Tumor Progressionに伴うBcl-2ファミリー蛋白の変化とそれらをターゲットとした治療の有効性の検討2018
- Author(s)
  前田祐三，高橋広城，柳田　剛，仲井　希，安藤菜奈子，志賀一慶，廣川高久，原　賢康，石黒秀行，松尾洋一，瀧口修司
- Organizer
  第51回制癌剤適応研究会
- Data Source
  KAKENHI-PROJECT-18K16371
[Presentation] Bevacizumabによる大腸癌化学療法治療中患者の血漿VEGF値の推移2018
- Author(s)
  安藤菜奈子，原賢康，柳田剛，前田祐三，志賀一慶，廣川高久，高橋広城，石黒秀行，松尾洋一，瀧口修司
- Organizer
  第73回日本消化器外科学会総会
- Data Source
  KAKENHI-PROJECT-16K10547
[Presentation] bevacizumab投与における血中VEGF値の推移と治療効果への影響2018
- Author(s)
  原賢康，柳田剛，安藤菜奈子，仲井希，前田祐三，廣川高久，志賀一慶，高橋広城，石黒秀行，松尾洋一，瀧口修司
- Organizer
  第56回日本癌治療学会学術集会
- Data Source
  KAKENHI-PROJECT-16K10547
[Presentation] STAT3/Bcl-xL/Mcl-1シグナルを介したApigeninによる大腸がんアポトーシス誘導効果の検討2018
- Author(s)
  前田祐三，高橋広城，原　賢康，廣川高久，志賀一慶，安藤菜奈子，柳田　剛，仲井　希，石黒秀行，松尾洋一，瀧口修司
- Organizer
  第118回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-18K16371
[Presentation] 大腸癌におけるbevacizumab療法とVEGF-A/PIGF産生に関する免疫組織学的検討2018
- Author(s)
  仲井　希，原　賢康，安藤菜奈子，柳田　剛，前田祐三，廣川高久，志賀一慶，高橋広城，石黒秀行，松尾洋一，瀧口修司
- Organizer
  第26回日本消化器関連学会週間
- Data Source
  KAKENHI-PROJECT-18K16371
[Presentation] StageII結腸直腸癌において術前血清IL-6値の術後再発危険因子として有用性2017
- Author(s)
  志賀一慶、原　賢康、安藤菜奈子、長﨑高也、前田祐三、高橋広城、柳田　剛、竹山廣光
- Organizer
  第13回日本消化管学会総会学術集会
- Place of Presentation
  名古屋国際会議場（愛知県・名古屋市）
- Year and Date
  2017-02-17
- Data Source
  KAKENHI-PROJECT-16K10547
[Presentation] 腹腔鏡下大腸切除時における腹腔内遺残癌細胞のRT-PCRによる検出2016
- Author(s)
  原　賢康、佐川弘之、志賀一慶、社本智也、坪井　謙、坂本宣弘、高橋広城、寺下幸夫、中西速夫、竹山廣光
- Organizer
  第71回日本消化器外科学会総会
- Place of Presentation
  あわぎんホール（徳島県・徳島市）
- Year and Date
  2016-07-14
- Data Source
  KAKENHI-PROJECT-16K10547
[Presentation] 腹腔鏡下大腸切除術時における有利癌細胞の有無とその適応について2016
- Author(s)
  原　賢康、柳田　剛、安藤菜奈子、佐川弘之、志賀一慶、坪井　謙、高橋広城、竹山廣光
- Organizer
  第29回日本内視鏡外科学会総会
- Place of Presentation
  パシフィコ横浜（神奈川県・西区）
- Year and Date
  2016-12-08
- Data Source
  KAKENHI-PROJECT-16K10547
[Presentation] 大腸癌手術時におけるICGによる吻合部血流の評価2016
- Author(s)
  原　賢康、柳田　剛、安藤菜奈子、志賀一慶、佐川弘之、高橋広城、竹山廣光
- Organizer
  第71回日本大腸肛門病学会学術集会
- Place of Presentation
  三重大学（三重県・津市）
- Year and Date
  2016-11-18
- Data Source
  KAKENHI-PROJECT-16K10547

1. 高橋広城 (30381792)

# of Collaborated Projects: 4 results

# of Collaborated Products: 16 results
2. HARA MASAYASU (80528860)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
3. Kaori Watanabe (20871263)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
4. Ushigome Hajime (00881327)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 松尾洋一 (40381800)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
6. 瀧口修司 (00301268)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
7. 廣川高久 (40592499)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 前田祐三

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Shiga Kazuyoshi 志賀 一慶

shiga kazuyoshi 志賀 一慶

Research Projects

Research Products

Co-Researchers

Elucidation of the mechanism of colorectal cancer progression mediated by cancer-associated fibroblasts and Chitinase 3-like 1

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Oncological Impact Resulting from Cutting into Colorectal Cancer and Its Clinical Application

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Overcoming acquisition of anti-angiogenic drug resistance by cancer stromal cell-derived MCP-1

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the mechanism of drug resistance in colorectal cancer focusing on the peri-tumour microenvironment and its application to treatmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Antitumor effect by signal inhibition in cancer-related fibroblasts

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Chitinase 3-like 1 secreted from cancer-associated fibroblasts promotes tumor angiogenesis via interleukin-8 secretion in colorectal cancer2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Eicosapentaenoic acid suppresses angiogenesis via reducing secretion of IL-6 and VEGF from colon cancer associated fibroblasts2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Apigenin induces apoptosis by suppressing Bcl-xl and Mcl-1 simultaneously via signal transducer and activator of transcription 3 signaling in colon cancer2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] High serum levels of interleukin-6 in patients with advanced or metastatic colorectal cancer: The effect on the outcome and the response to chemotherapy plus bevacizumab.2016

Author(s)

Journal Title

DOI

Data Source

[Presentation] 癌関連線維芽細胞によるChitinase 3-like 1とIL-8が関与した大腸癌血管新生メカニズム2022

Author(s)

Organizer

Data Source

[Presentation] 大腸癌微小環境におけるChitinase 3-like 1が関与した癌血管新生メカニズムの解明2022

Author(s)

Organizer

Data Source

[Presentation] CAF由来Chitinase 3-like 1が大腸癌の血管新生に及ぼす影響2021

Author(s)

Organizer

Data Source

[Presentation] 炎症性サイトカインIL-6は大腸癌の予後予測因子となり得るか？2021

Author(s)

Organizer

Data Source

[Presentation] 癌関連線維芽細胞によるChitinase 3-like 1の大腸癌血管新生に対する効果2021

Author(s)

Organizer

Data Source

[Presentation] 癌関連線維芽細胞によるChitinase 3-like 1が関与した大腸癌進展メカニズムの解明2021

Author(s)

Organizer

Data Source

[Presentation] In vitroにおけるcolon cancer-associated fibroblastから産生されるIL-6とVEGFに対するEPAの抑制効果とそれに伴う血管新生抑制2018

Shiga Kazuyoshi 志賀一慶

shiga kazuyoshi 志賀一慶

[Presentation] Tumor Progressionに伴うBcl-2ファミリー蛋白の変化とそれらをターゲットとした治療の有効性の検討2018