aimoto megumi 相本恵美

… Alternative Names

相本恵美アイモトメグミ

AIMOTO Megumi 相本恵美

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Researcher Number	20756358
Other IDs
Affiliation (Current)	2025: 東邦大学, 薬学部, 助教
Affiliation (based on the past Project Information) *help	2023: 東邦大学, 薬学部, 助教 2020 – 2021: 東邦大学, 薬学部, 助教 2015 – 2017: 東邦大学, 薬学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 53020:Cardiology-related / 0903:Organ-based internal medicine and related fields Except Principal Investigator Applied pharmacology
Keywords	Principal Investigator 慢性容量負荷 / 心房細動 / 薬物療法 / 疾患モデル動物 / 心血管・血液 / 臨床心臓学 / 容量負荷 / リモデリング / アルドステロン / トリガー … More Except Principal Investigator … More 動静脈瘻 / TRPC3チャネル / アルドステロン / 慢性容量負荷 / 心房拡大 / 心房細動 Less

Research on the establishment of novel drug treatment strategies for atrial fibrillation inspired by cancer pharmacotherapyPrincipal Investigator
- Principal Investigator
  
  相本恵美
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Toho University
Elucidation of the mechanisms involved in the establishment of the basis for the development of trigger-based AFPrincipal Investigator
- Principal Investigator
  
  AIMOTO Megumi
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0903:Organ-based internal medicine and related fields
- Research Institution
  Toho University
ANALYSIS OF THERAPEUTIC TARGET MOLECULES FOR SUSTAINED ATRIAL FIBRILLATION CAUSED BY CHRONIC VOLUME OVERLOAD
- Principal Investigator
  
  TAKAHARA Akira
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  Toho University

All 2023 2022 2021 2018 2017 2016 2015 Other

All Journal Article Presentation Other

[Journal Article] Differential Effects of Ca2+ Channel Blockers Nifedipine and Cilnidipine on Arterial Elasticity in the Aortic and Femoral Arterial Segments of Anesthetized Rabbits2023
- Author(s)
 Akira Sato, Yoshinobu Nagasawa, Honami Suzuki, Kiyoshi Sakuma, Tatsuo Chiba, Megumi Aimoto, Akira Takahara
- Journal Title
 
 Biological and Pharmaceutical Bulletin
 
 Volume: 46 Issue: 9 Pages: 1324-1331
- DOI
 10.1248/bpb.b23-00391
- ISSN
 0918-6158, 1347-5215
- Year and Date
 2023-09-01
- Language
 English
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-22K09032, KAKENHI-PROJECT-23K07564, KAKENHI-PROJECT-23K11836
[Journal Article] The Antiarrhythmic Action of the Na+/Ca2+ Exchanger Inhibitor SEA0400 on Drug-Induced Long QT Syndrome Depends on the Severity of Proarrhythmic Conditions in Anesthetized Atrioventricular Block Rabbits2023
- Author(s)
 Satoshi Kawakami, Kazuhiro Takada, Megumi Aimoto, Yoshinobu Nagasawa, Taichi Kusakabe , Keisuke Kato , Akira Takahara
- Journal Title
 
 Biological and Pharmaceutical Bulletin
 
 Volume: 46 Issue: 8 Pages: 1120-1127
- DOI
 10.1248/bpb.b23-00202
- ISSN
 0918-6158, 1347-5215
- Year and Date
 2023-08-01
- Language
 English
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-22K09032, KAKENHI-PROJECT-23K06034, KAKENHI-PROJECT-23K07564
[Journal Article] Role of Rho Kinase in Regulating Arterial Stiffness in Anesthetized Rabbits2023
- Author(s)
  Akira Takahara, Manami Matsumoto, Akira Sato, Shuto Inose, Megumi Aimoto, Yoshinobu Nagasawa
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 46 Issue: 12 Pages: 1846-1850
- DOI
  10.1248/bpb.b23-00591
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2023-12-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K09032, KAKENHI-PROJECT-23K07564, KAKENHI-PROJECT-23K11836
[Journal Article] Chronic Volume Overload Caused by Abdominal Aorto-Venocaval Shunt Provides Arrhythmogenic Substrates in the Rat Atrium2022
- Author(s)
  Aimoto Megumi、Yagi Keita、Ezawa Aya、Tsuneoka Yayoi、Kumada Kohei、Hasegawa Takeshi、Kuze Tetsuo、Chiba Toshiki、Nagasawa Yoshinobu、Tanaka Hikaru、Takahara Akira
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 45 Issue: 5 Pages: 635-642
- DOI
  10.1248/bpb.b22-00031
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2022-05-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K22924, KAKENHI-PROJECT-22K09032
[Journal Article] Electrophysiological Response to Acehytisine Was Modulated by Aldosterone in Rats with Aorto-Venocaval Shunts2021
- Author(s)
  Cao Xin、Aimoto Megumi、Nagasawa Yoshinobu、Zhang Han-Xiao、Zhang Cheng-Shun、Takahara Akira
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 44 Issue: 8 Pages: 1044-1049
- DOI
  10.1248/bpb.b20-00974
- NAID
  130008070537
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2021-08-01
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K22924
[Journal Article] Influence of chronic volume overload-induced atrial remodeling on electrophysiological responses to cholinergic receptor stimulation in the isolated rat atria2018
- Author(s)
  Cao Xin、Aimoto Megumi、Fukumoto Marie、Nagasawa Yoshinobu、Tanaka Hikaru、Takahara Akira
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 136 Issue: 2 Pages: 73-78
- DOI
  10.1016/j.jphs.2017.12.009
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H07135, KAKENHI-PROJECT-15K08598
[Journal Article] The anaesthetized rabbit with acute atrioventricular block provides a new model for detecting drug-induced Torsade de Pointes2017
- Author(s)
  Hagiwara Mihoko、Shibuta Seiji、Takada Kazuhiro、Kambayashi Ryuichi、Nakajo Misako、Aimoto Megumi、Nagasawa Yoshinobu、Takahara Akira
- Journal Title
  
  British Journal of Pharmacology
  
  Volume: 174 Issue: 15 Pages: 2591-2605
- DOI
  10.1111/bph.13870
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08598
[Journal Article] In vivo analysis of torsadogenic potential of an antipsychotic drug paliperidone using the acute atrioventricular block rabbit as a proarrhythmia model.2016
- Author(s)
  Hagiwara M, Kambayashi R, Aimoto M, Nagasawa Y, Takahara A.
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 132 Issue: 1 Pages: 48-54
- DOI
  10.1016/j.jphs.2016.05.001
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K08598
[Presentation] Different modificatory actions of isoproterenol and aldosterone on the chronic volume overload-induced remodeled heart in rats2023
- Author(s)
  相本恵美, 永澤悦伸, 高原章
- Organizer
  第69回日本不整脈心電学会学術集会
- Data Source
  KAKENHI-PROJECT-23K07564
[Presentation] Dapagliflozin の慢性投与が慢性容量負荷モデルラット心房の催不整脈特性に及ぼす影響2023
- Author(s)
  佐々木悠里, 相本恵美, 永澤悦伸, 高原章
- Organizer
  第67回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-23K07564
[Presentation] 慢性容量負荷モデルラットにおける左右心房の電気生理学的特徴の相違－左房のin vivo電気生理学検査法の確立を通じて－2023
- Author(s)
  宮本雄太, 相本恵美, 永澤悦伸, 高原章
- Organizer
  第67回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-23K07564
[Presentation] Angiotensin Ⅱの慢性投与が慢性容量負荷による心房リモデリングに　与える影響―持続的な昇圧を認めない用量における検討―2023
- Author(s)
  市川かれん, 相本恵美, 永澤悦伸, 高原章
- Organizer
  第67回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-23K07564
[Presentation] 慢性容量負荷・aldosterone負荷モデルラットの催不整脈特性獲得に至るプロセスの解析2023
- Author(s)
  近藤瑞希, 相本恵美, 永澤悦伸, 高原章
- Organizer
  第67回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-23K07564
[Presentation] Aldosterone enhances stability of atrial fibrillation in the rat model of chronic volume overload2022
- Author(s)
  Megumi Aimoto, Ai Utsunomiya, Rina Kikuchi, Yoshinobu Nagasawa, Akira Takahara
- Organizer
  第95回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-20K22924
[Presentation] 心房におけるトリガー発生は慢性的なaldosterone負荷と容量負荷の共存により増強する2021
- Author(s)
  相本恵美、永澤悦伸、高原章
- Organizer
  第145回日本薬理学会関東部会
- Data Source
  KAKENHI-PROJECT-20K22924
[Presentation] Manifestation of proarrhythmic properties of IKACh blocker tertiapin in the rat dilated atria caused by chronic volume overload2021
- Author(s)
  Megumi Aimoto, Ryohei Suzuki, Yuka Taneichi, Yoshinobu Nagasawa, Akira Takahara
- Organizer
  第94回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-20K22924
[Presentation] Influence of Chronic Volume Overload-induced Atrial Remodeling on Electrophysiological Responses to Cholinergic Receptor Stimulation in the Isolated Rat Atria.2018
- Author(s)
  相本恵美，永澤悦伸，高原章
- Organizer
  第82回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-15K08598
[Presentation] Sphingosine-1-phosphate Receptor Modulator Fingolimod Suppresses Atrial Fibrillation in Rats with Atrial Enlargement Caused by Chronic Volume Overload.2018
- Author(s)
  相本恵美，永澤悦伸，高原章
- Organizer
  第82回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-15K08598
[Presentation] 新規心房細動モデルラットの心房細動の持続化におけるaldosteroneの役割2017
- Author(s)
  相本恵美, 永澤悦伸, 高原章
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際会議場（宮城県仙台市）
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-15K08598
[Presentation] Aldosterone慢性負荷で生じる心房細動の持続化におけるNFATの関与 ―動静脈モデルラットを用いた検討―2017
- Author(s)
  小田原一功，相本恵美，永澤悦伸，高原章
- Organizer
  第136回日本薬理学会関東部会
- Data Source
  KAKENHI-PROJECT-15K08598
[Presentation] 急性房室ブロックウサギはアドレナリンα1受容体遮断作用を有するQT延長薬の催不整脈作用を検出できる2017
- Author(s)
  萩原美帆子, 神林隆一, 仲條美佐子, 永澤悦伸, 相本恵美, 高原章
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際会議場（宮城県仙台市）
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-15K08598
[Presentation] 薬物性QT延長症候群に関連する有害事象報告数の抗ヒスタミン薬世代間の違い－薬物の心臓電気薬理学的作用からの検討2017
- Author(s)
  永澤悦伸, 小林加寿子, 相本恵美, 高原章
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際会議場（宮城県仙台市）
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-15K08598
[Presentation] Chronically administered aldosterone can promote stability of atrial fibrillation in the rat model of chronic volume overload2017
- Author(s)
  相本恵美, 永澤悦伸, 高原章
- Organizer
  第81回日本循環器学会学術集会
- Place of Presentation
  ANAクラウンプラザホテル金沢（石川県金沢市）
- Year and Date
  2017-03-19
- Data Source
  KAKENHI-PROJECT-15K08598
[Presentation] 慢性容量負荷による心房拡大ラットにおける心房細動誘発性の分析2016
- Author(s)
  相本恵美, 八木啓太, 江沢亜耶, 高原章
- Organizer
  第89回日本薬理学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-03-09
- Data Source
  KAKENHI-PROJECT-15K08598
[Presentation] The influence of aldosterone on the inducibility of atrial fibrillation in rat abdominal aorto-venocaval shunt model.2016
- Author(s)
  相本恵美, 永澤悦伸, 高原章
- Organizer
  第63回日本不整脈心電学会学術大会
- Place of Presentation
  札幌コンベンションセンター（北海道札幌市）
- Year and Date
  2016-07-17
- Data Source
  KAKENHI-PROJECT-15K08598
[Presentation] 抗アレルギー薬の催不整脈リスクに関する検討：in vivoおよびin vitro電気生理学的作用に基づいた統合的評価2016
- Author(s)
  小林加寿子, 相本恵美, 永澤悦伸, 高原章
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-15K08598
[Presentation] ウサギ催不整脈モデルにおける抗ヒスタミン薬 hydroxyzine の作用2016
- Author(s)
  仲條美佐子, 萩原美帆子, 永澤悦伸, 相本恵美, 高原章
- Organizer
  第60回日本薬学会関東支部大会
- Place of Presentation
  東京大学（東京都文京区）
- Year and Date
  2016-09-17
- Data Source
  KAKENHI-PROJECT-15K08598
[Presentation] Aldosterone is a strong biological mediator for induction of AF in rats with pathological condition of chronic volume overload.2016
- Author(s)
  相本恵美, 灘みづき, 高原章
- Organizer
  第80回日本循環器学会学術集会
- Place of Presentation
  仙台国際会議場（宮城県仙台市）
- Year and Date
  2016-03-20
- Data Source
  KAKENHI-PROJECT-15K08598
[Presentation] Effects of vasodilators on the cardio-ankle vascular index (CAVI) in anesthetized rabbits.2016
- Author(s)
  Kiyoshi Sakuma, Tatsuo Chiba, Takenori Morishita, Mari Yamanaka, Megumi Aimoto, Yoshinobu Nagasawa, Koji Shirai, Akira Takahara
- Organizer
  The 26th Meeting of the International Society of Hypertension (Hypertension Seoul 2016)
- Place of Presentation
  ソウル（韓国）
- Year and Date
  2016-09-28
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08598
[Presentation] Involvement of TRPC3 channels in the aldosterone-induced atrial fibrillation in the rat hypertrophy model with chronic volume overload.2015
- Author(s)
  相本恵美, 灘みづき, 高原章
- Organizer
  第79回日本循環器学会学術集会
- Place of Presentation
  グランフロント大阪（大阪府大阪市）
- Year and Date
  2015-04-25
- Data Source
  KAKENHI-PROJECT-15K08598
[Presentation] 新規心房細動モデルラットにおける dexamethasone の抗心房細動作用2015
- Author(s)
  梛野健, 相本恵美, 高原章
- Organizer
  第59回日本薬学会関東支部大会
- Place of Presentation
  日本大学薬学部（千葉県船橋市）
- Year and Date
  2015-09-12
- Data Source
  KAKENHI-PROJECT-15K08598
[Presentation] Proarrhythmic potential of the rabbit heart under bradycardiac conditions of acute and chronic atrioventricular block.2015
- Author(s)
  萩原美帆子, 相本恵美, 高原章
- Organizer
  第30回日本不整脈学会学術大会／第32回日本心電学会学術集会合同学術大会
- Place of Presentation
  京都国際会議場（京都府京都市）
- Year and Date
  2015-07-29
- Data Source
  KAKENHI-PROJECT-15K08598
[Presentation] 抗精神病薬が有する催不整脈特性の比較：新規不整脈検出モデルを用いた検討2015
- Author(s)
  神林隆一, 萩原美帆子, 高田一唐, 仲條美佐子, 相本恵美, 高原章
- Organizer
  第133回日本薬理学会関東部会
- Place of Presentation
  柏の葉カンファレンスセンター（千葉県柏市）
- Year and Date
  2015-10-10
- Data Source
  KAKENHI-PROJECT-15K08598
[Presentation] 動静脈瘻による慢性容量負荷がcarbacholで誘発される心房細動に与える影響2015
- Author(s)
  相本恵美, 福本真利江, 田中光, 高原章
- Organizer
  第133回日本薬理学会関東部会
- Place of Presentation
  柏の葉カンファレンスセンター（千葉県柏市）
- Year and Date
  2015-10-10
- Data Source
  KAKENHI-PROJECT-15K08598
[]

1. TAKAHARA Akira (80377481)

# of Collaborated Projects: 1 results

# of Collaborated Products: 20 results
2. 曹新

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

aimoto megumi 相本 恵美

相本 恵美 アイモト メグミ

AIMOTO Megumi 相本 恵美

Research Projects

Research Products

Co-Researchers

Research on the establishment of novel drug treatment strategies for atrial fibrillation inspired by cancer pharmacotherapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the mechanisms involved in the establishment of the basis for the development of trigger-based AFPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ANALYSIS OF THERAPEUTIC TARGET MOLECULES FOR SUSTAINED ATRIAL FIBRILLATION CAUSED BY CHRONIC VOLUME OVERLOAD

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Differential Effects of Ca<sup>2+</sup> Channel Blockers Nifedipine and Cilnidipine on Arterial Elasticity in the Aortic and Femoral Arterial Segments of Anesthetized Rabbits2023

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] The Antiarrhythmic Action of the Na<sup>+</sup>/Ca<sup>2+</sup> Exchanger Inhibitor SEA0400 on Drug-Induced Long QT Syndrome Depends on the Severity of Proarrhythmic Conditions in Anesthetized Atrioventricular Block Rabbits2023

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] Role of Rho Kinase in Regulating Arterial Stiffness in Anesthetized Rabbits2023

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] Chronic Volume Overload Caused by Abdominal Aorto-Venocaval Shunt Provides Arrhythmogenic Substrates in the Rat Atrium2022

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] Electrophysiological Response to Acehytisine Was Modulated by Aldosterone in Rats with Aorto-Venocaval Shunts2021

Author(s)

Journal Title

DOI

NAID

ISSN

Year and Date

Language

Data Source

[Journal Article] Influence of chronic volume overload-induced atrial remodeling on electrophysiological responses to cholinergic receptor stimulation in the isolated rat atria2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The anaesthetized rabbit with acute atrioventricular block provides a new model for detecting drug-induced Torsade de Pointes2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] In vivo analysis of torsadogenic potential of an antipsychotic drug paliperidone using the acute atrioventricular block rabbit as a proarrhythmia model.2016

Author(s)

Journal Title

DOI

Data Source

aimoto megumi 相本恵美

相本恵美アイモトメグミ

AIMOTO Megumi 相本恵美

[Presentation] Angiotensin Ⅱの慢性投与が慢性容量負荷による心房リモデリングに　与える影響―持続的な昇圧を認めない用量における検討―2023

[Presentation] 薬物性QT延長症候群に関連する有害事象報告数の抗ヒスタミン薬世代間の違い－薬物の心臓電気薬理学的作用からの検討2017