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SEKIHARA Kazumasa  関原 和正

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Sekihara Kazumasa  関原 和正

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Researcher Number 20761662
Other IDs
Affiliation (Current) 2025: 宮崎大学, 医学部, 助教
2025: 横浜市立大学, 医学研究科, 博士研究員
Affiliation (based on the past Project Information) *help 2022 – 2023: 地方独立行政法人神奈川県立病院機構神奈川県立がんセンター(臨床研究所), 臨床研究所がん生物学部, 任期付研究員
2021: 地方独立行政法人神奈川県立病院機構神奈川県立がんセンター(臨床研究所), 臨床研究所, 任期付研究員
2019 – 2020: 浜松医科大学, 医学部, 助教
2018: 横浜市立大学, 医学研究科, 博士研究員
2016 – 2017: 順天堂大学, 医学(系)研究科(研究院), 博士研究員
Review Section/Research Field
Principal Investigator
Basic Section 52040:Radiological sciences-related / Basic Section 57060:Surgical dentistry-related / Radiation science
Except Principal Investigator
Basic Section 52040:Radiological sciences-related
Keywords
Principal Investigator
潜在的致死損傷回復 / DNA修復 / 細胞外小胞 / がん微小環境 / 三次元培養 / 重粒子線 / 放射線治療抵抗性 / がん幹細胞 / 口腔がん / SIRT6 … More / DNA二重鎖切断 / クロマチン構造変化 / 放射線治療生物学 / PLDR阻害 / 放射線治療 / DNA損傷・修復 / クロマチンリモデリング … More
Except Principal Investigator
腸脳相関 / 腸内細菌叢 / アブスコパル効果 / 放射線治療 / CXCL2 Less
  • Research Projects

    (4 results)
  • Research Products

    (40 results)
  • Co-Researchers

    (10 People)
  •  従来法とオルガノイド培養法の重粒子線による生物効果解析Principal Investigator

    • Principal Investigator
      関原 和正
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52040:Radiological sciences-related
    • Research Institution
      Kanagawa Cancer Center Research Institute
  •  CXCL2依存性の腸脳相関を介した放射線治療効果増感についての検討

    • Principal Investigator
      氷室 秀知
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52040:Radiological sciences-related
    • Research Institution
      Kanagawa Cancer Center Research Institute
  •  The role of SIRT6 in oral cancer stem cells leading to radiation tolerancePrincipal Investigator

    • Principal Investigator
      Sekihara Kazumasa
    • Project Period (FY)
      2019 – 2022
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 57060:Surgical dentistry-related
    • Research Institution
      Kanagawa Cancer Center Research Institute
      Hamamatsu University School of Medicine
  •  The Involvement of PLDR inhibition and unreparable DNA double-strand breaks as a basis for radiotherapyPrincipal Investigator

    • Principal Investigator
      Sekihara Kazumasa
    • Project Period (FY)
      2016 – 2019
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Radiation science
    • Research Institution
      Hamamatsu University School of Medicine
      Yokohama City University
      Juntendo University

All 2024 2023 2022 2020 2019 2018 2017 2016

All Journal Article Presentation

  • [Journal Article] Validation of EZH2 Inhibitor Efficiency in Anaplastic Thyroid Carcinoma Cell Lines2023

    • Author(s)
      NAKAYAMA HIROTAKA、SAITO NAO、KASAJIMA RIKA、SUGANUMA NOBUYASU、RINO YASUSHI、MASUDO KATSUHIKO、YAMAZAKI HARUHIKO、TODA SOJI、SEKIHARA KAZUMASA、IWASAKI HIROYUKI、HOSHINO DAISUKE
    • Journal Title

      Anticancer Research

      Volume: 43 Issue: 3 Pages: 1073-1077

    • DOI

      10.21873/anticanres.16252

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K09052, KAKENHI-PROJECT-19K19206, KAKENHI-PROJECT-22K18202
  • [Journal Article] TROP-2, Nectin-4, GPNMB, and B7-H3 Are Potentially Therapeutic Targets for Anaplastic Thyroid Carcinoma2022

    • Author(s)
      Toda Soji、Sato Shinya、Saito Nao、Sekihara Kazumasa、Matsui Ai、Murayama Daisuke、Nakayama Hirotaka、Suganuma Nobuyasu、Okubo Yoichiro、Hayashi Hiroyuki、Iwasaki Hiroyuki、Miyagi Yohei、Hoshino Daisuke
    • Journal Title

      Cancers

      Volume: 14 Issue: 3 Pages: 579-579

    • DOI

      10.3390/cancers14030579

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K18202, KAKENHI-PROJECT-20K09422, KAKENHI-PROJECT-19K19206
  • [Journal Article] Evaluation of X-ray and carbon-ion beam irradiation with chemotherapy for the treatment of cervical adenocarcinoma cells in 2D and 3D cultures2022

    • Author(s)
      Sekihara Kazumasa、Himuro Hidetomo、Saito Nao、Ota Yukihide、Kouro Taku、Kusano Yohsuke、Minohara Shinichi、Hirayama Ryoichi、Katoh Hiroyuki、Sasada Tetsuro、Hoshino Daisuke
    • Journal Title

      Cancer Cell International

      Volume: 22 Issue: 1 Pages: 391-391

    • DOI

      10.1186/s12935-022-02810-9

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K18202, KAKENHI-PROJECT-21H02995, KAKENHI-PROJECT-19K19206
  • [Journal Article] オルガノイドを用いた個々の患者に対する薬剤効果予測系の確立 特集 バイオマテリアルを三次元で創る・視る・使う2022

    • Author(s)
      星野大輔, 齋藤菜緒, 関原和正
    • Journal Title

      バイオマテリアル-生体材料-

      Volume: 40(4) Pages: 312-317

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K19206
  • [Journal Article] The Expression of SIRT6 Is Associated With Treatment Outcome in Elder Patients With Oral Cancer2022

    • Author(s)
      YOSHII HARUKA、SEKIHARA KAZUMASA、IDETA YUKA、NAKAJIMA SHINTARO、KATO IKUMA、OKUBO-SATO MAKIKO、SUGIURA KEI、MITSUDO KENJI、KIOI MITOMU
    • Journal Title

      Anticancer Research

      Volume: 42 Issue: 8 Pages: 3815-3823

    • DOI

      10.21873/anticanres.15872

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K17031, KAKENHI-PROJECT-19K19206
  • [Journal Article] Inhibition of FAO in AML co-cultured with BM adipocytes: mechanisms of survival and chemosensitization to cytarabine.2018

    • Author(s)
      Tabe Y, Saitoh K, Yang H, Sekihara K, Yamatani K, Ruvolo V, Taka H, Kaga N, Kikkawa M, Arai H, Miida T, Andreeff M, Spagnuolo PA, Konopleva M.
    • Journal Title

      Sci Rep

      Volume: 8 Issue: 1 Pages: 16837-16837

    • DOI

      10.1038/s41598-018-35198-6

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K07424, KAKENHI-PROJECT-18K07829, KAKENHI-PROJECT-16K19855, KAKENHI-PROJECT-15K08653, KAKENHI-PROJECT-16K01834
  • [Journal Article] Correction: Low-dose ionizing radiation exposure represses the cell cycle and protein synthesis pathways in in vitro human primary keratinocytes and U937 cell lines2018

    • Author(s)
      Sekihara Kazumasa、Saitoh Kaori、Yang Haeun、Kawashima Haruki、Kazuno Saiko、Kikkawa Mika、Arai Hajime、Miida Takashi、Hayashi Nobuhiro、Niyonsaba Francois、Sasai Keisuke、Tabe Yoko
    • Journal Title

      PLOS ONE

      Volume: 13 Issue: 10 Pages: 1-1

    • DOI

      10.1371/journal.pone.0205581

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K10254, KAKENHI-PROJECT-16K19855
  • [Journal Article] Inhibition of mTOR kinase as a therapeutic target for acute myeloid leukemia2017

    • Author(s)
      Tabe Yoko、Tafuri Agostino、Sekihara Kazumasa、Yang Haeun、Konopleva Marina
    • Journal Title

      Expert Opinion on Therapeutic Targets

      Volume: 21 Issue: 7 Pages: 705-714

    • DOI

      10.1080/14728222.2017.1333600

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K19855
  • [Journal Article] Targeting mantle cell lymphoma metabolism and survival through simultaneous blockade of mTOR and nuclear transporter exportin-1.2017

    • Author(s)
      Sekihara K, Saitoh K, Han L, Ciurea S, Yamamoto S, Kikkawa M, Kazuno S, Taka H, Kaga N, Arai H, Miida T, Andreeff M, Konopleva M, Tabe Y.
    • Journal Title

      Oncotarget

      Volume: in press Issue: 21 Pages: 34552-34564

    • DOI

      10.18632/oncotarget.16602

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08653, KAKENHI-PROJECT-16K19855, KAKENHI-PROJECT-16K01834, KAKENHI-PROJECT-15K08624
  • [Journal Article] Bone Marrow Adipocytes Facilitate Fatty Acid Oxidation Activating AMPK and a Transcriptional Network Supporting Survival of Acute Monocytic Leukemia Cells.2017

    • Author(s)
      Tabe Y, Yamamoto S, Saitoh K, Sekihara K, Monma N, Ikeo K, Mogushi K, Shikami M, Ruvolo V, Ishizawa J, Hail N Jr, Kazuno S, Igarashi M, Matsushita H, Yamanaka Y, Arai H, Nagaoka I, Miida T, Hayashizaki Y, Konopleva M, Andreeff M.
    • Journal Title

      Cancer Res.

      Volume: 77 Issue: 6 Pages: 1453-1464

    • DOI

      10.1158/0008-5472.can-16-1645

    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08653, KAKENHI-PROJECT-16K08976, KAKENHI-PROJECT-16K19855, KAKENHI-PROJECT-15K08624
  • [Presentation] The antitumor effects of carbon ion irradiation on anaplastic thyroid carcinoma cells2024

    • Author(s)
      Kazumasa Sekihara, Hidetomo Himuro, Ryoichi Hirayama, Tetsuro Sasada, Daisuke Hoshino
    • Organizer
      Biological Effects & Application of Radiation (BEAR) 2024
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K07100
  • [Presentation] 3D培養における低酸素誘導治療抵抗性を重粒子線により打破する2023

    • Author(s)
      関原和正, 氷室秀知, 齋藤菜緒, 星野大輔
    • Organizer
      第2回若手放射線影響研究会
    • Data Source
      KAKENHI-PROJECT-19K19206
  • [Presentation] 甲状腺未分化がんの新規治療戦略における重粒子線治療の可能性2023

    • Author(s)
      関原和正, 氷室秀知, 平山亮一, 笹田哲朗, 星野大輔
    • Organizer
      第3回若手放射線影響研究会
    • Data Source
      KAKENHI-PROJECT-23K07100
  • [Presentation] 炭素線照射と分子標的薬の併用は甲状腺未分化がん細胞に対する抗腫瘍効果を相加的に増強する2023

    • Author(s)
      関原和正, 氷室秀知, 平山亮一, 笹田哲朗, 星野大輔
    • Organizer
      日本放射線影響学会第66回大会
    • Data Source
      KAKENHI-PROJECT-23K07100
  • [Presentation] 子宮頸部腺がん治療における重粒子線治療の優位性2023

    • Author(s)
      関原和正, 氷室秀知, 齋藤菜緒, 平山亮一, 星野大輔
    • Organizer
      第9回がんと代謝研究会in松山
    • Data Source
      KAKENHI-PROJECT-23K07100
  • [Presentation] 炭素線照射単独またはBRAF阻害剤、MEK阻害剤との併用は甲状腺未分化がんを効果的に死滅させる2023

    • Author(s)
      関原和正, 氷室秀知, 齋藤菜緒, 笹田哲朗, 星野大輔
    • Organizer
      第82回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-23K07100
  • [Presentation] 治療効果評価のための三次元培養モデルの有用性2023

    • Author(s)
      関原和正
    • Organizer
      日本量子医科学会第3回学術大会
    • Data Source
      KAKENHI-PROJECT-23K07100
  • [Presentation] Investigation for antitumor effect of carbon ion irradiation in cervical adenocarcinoma using a 3D spheroid culture model2023

    • Author(s)
      Kazumasa Sekihara, Hidetomo Himuro, Nao Saito, Yukihide Ota, Ryoichi Hirayama, Daisuke Hoshino
    • Organizer
      The 17th International Congress for Radiation Research
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K07100
  • [Presentation] 甲状腺未分化がんに対する重粒子線治療の効果2023

    • Author(s)
      関原和正, 氷室秀知, 齋藤菜緒, 平山亮一, 星野大輔
    • Organizer
      第32回日本がん転移学会学術集会・総会
    • Data Source
      KAKENHI-PROJECT-23K07100
  • [Presentation] 甲状腺乳頭癌のオルガノイド培養を用いた薬剤感受性および甲状腺分化マーカーの変動2022

    • Author(s)
      齋藤菜緒, 菅沼伸康, 戸田宗治, 岩崎博幸, 関原和正, 星野大輔
    • Organizer
      第31回 日本がん転移学会学術集会・総会
    • Data Source
      KAKENHI-PROJECT-19K19206
  • [Presentation] 甲状腺乳頭癌オルガノイドを用いた薬剤感受性および甲状腺分化マーカーの変動2022

    • Author(s)
      斎藤菜緒, 戸田宗治, 関原和正, 星野大輔
    • Organizer
      第81回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-19K19206
  • [Presentation] 二次元および三次元培養された子宮頸部腺癌に対するX線および重粒子線の効果2022

    • Author(s)
      関原和正, 氷室秀知, 齋藤菜緒, 太田幸秀, 星野大輔
    • Organizer
      日本放射線腫瘍学会第 35回学術大会
    • Data Source
      KAKENHI-PROJECT-19K19206
  • [Presentation] 二次元および三次元培養における子宮頸部腺がんの放射線感受性評価2022

    • Author(s)
      関原和正, 氷室秀知, 齋藤菜緒, 太田幸秀, 星野大輔
    • Organizer
      第31回 日本がん転移学会学術集会・総会
    • Data Source
      KAKENHI-PROJECT-19K19206
  • [Presentation] 子宮頸部腺がん三次元スフェロイドにおける炭素線照射の抗腫瘍効果2022

    • Author(s)
      関原和正, 氷室秀知, 斎藤菜緒, 太田幸秀, 笹田哲朗, 星野大輔
    • Organizer
      第81回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-19K19206
  • [Presentation] 骨髄細胞の流入と口腔癌幹細胞による治療抵抗性の分子機構2022

    • Author(s)
      関原和正, 中島慎太郎, 星野大輔, 來生知
    • Organizer
      第8回 がんと代謝研究会 in 佐渡
    • Data Source
      KAKENHI-PROJECT-19K19206
  • [Presentation] CD11b陽性骨髄細胞の流入と口腔癌幹細胞による治療抵抗性の分子メカニズム2020

    • Author(s)
      関原和正, 來生知
    • Organizer
      第79回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-19K19206
  • [Presentation] 治療抵抗性を誘導する骨髄細胞の流入と口腔癌幹細胞の分子メカニズム2019

    • Author(s)
      関原和正, 中島慎太郎, 來生知
    • Organizer
      日本放射線腫瘍学会第32回学術大会
    • Data Source
      KAKENHI-PROJECT-19K19206
  • [Presentation] 治療抵抗性を誘導する骨髄細胞の流入と口腔癌幹細胞の分子メカニズム2019

    • Author(s)
      関原和正, 中島慎太郎, 來生知
    • Organizer
      日本放射線腫瘍学会第32回学術大会
    • Data Source
      KAKENHI-PROJECT-16K19855
  • [Presentation] The direct and bystander effects of low dose radiation on skin infiltrating model2018

    • Author(s)
      Sekihara Kazumasa、Saitoh Kaori、Yang Haeun、Miida Takashi、Sasai Keisuke、Tabe Yoko
    • Organizer
      European Radiation Research 2018
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K19855
  • [Presentation] 皮膚微小環境における低線量放射線の直接効果およびバイスタンダー効果2018

    • Author(s)
      関原和正、斎藤香里、梁夏恩、三井田孝、笹井啓資、 田部陽子
    • Organizer
      日本放射線腫瘍学会第31回学術大会
    • Data Source
      KAKENHI-PROJECT-16K19855
  • [Presentation] Inhibiton of mTOR enhances the antitumor effects of XPO1 inhibitor KPT-185 in mantle cell lymphoma.2017

    • Author(s)
      関原和正, 梁夏恩, 田部陽子.
    • Organizer
      第76回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-16K19855
  • [Presentation] mTOR/XPO1 dual inhibition represses pro-survival metabolism and induces antitumor effects on human mantle cell lymphoma2017

    • Author(s)
      Sekihara K, Saitoh K, Yang H, Miida T, Tabe Y.
    • Organizer
      The 29th World Association of Societies of Pathology and Laboratory Medicine (WASPaLM)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K19855
  • [Presentation] MCLにおけるmTOR、XPO1阻害によるエネルギー代謝抑制2017

    • Author(s)
      関原和正, 斎藤香里, 梁夏恩, 三井田孝, 田部陽子.
    • Organizer
      第5回がんと代謝研究会
    • Data Source
      KAKENHI-PROJECT-16K19855
  • [Presentation] The direct and bystander effects of low-dose radiation on the skin immune system.2017

    • Author(s)
      Sekihara K, Saitoh K, Yang H, Miida T, Sasai K, Tabe Y.
    • Organizer
      4th Asian Congress of Radiation Research (ACRR)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K19855
  • [Presentation] Combinatorial Inhibition of mTOR and Exportin-1 (XPO1) Represses Cell Survival Via Metabolic Modulation of Pro-survival Pathways in Mantle Cell Lymphomas.2017

    • Author(s)
      Sekihara K, Saitoh K, Yang H, Miida T, Andreeff M, Tabe Y.
    • Organizer
      European Society for Medical Oncology (ESMO) 2017 congress.
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K19855
  • [Presentation] ヒト表皮角化細胞および単球系細胞に対する低線量放射線の影響2016

    • Author(s)
      関原和正、斉藤香里、河島陽来、林宣宏、笹井啓資、三井田孝、田部陽子
    • Organizer
      日本放射線影響学会第59回大会
    • Place of Presentation
      JMSアステールプラザ(広島市)
    • Year and Date
      2016-10-26
    • Data Source
      KAKENHI-PROJECT-16K19855
  • [Presentation] The simultaneous blockade of mTOR and nuclear transporter exportin-1 induces synergistic antitumor effect through pro-survival metabolism in mantle cell lymphoma2016

    • Author(s)
      Kazumasa Sekihara, Kaori Saitoh, Takashi Miida, Michael Andreeff, Marina Konopleva,Yoko Tabe
    • Organizer
      The fourth annual meeting of the Society of Hematologic Oncology (SOHO 2016)
    • Place of Presentation
      Westin Galleria (Houston)
    • Year and Date
      2016-09-07
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K19855
  • [Presentation] マントル細胞リンパ腫におけるXPO1阻害剤KPT-185とmTOR阻害剤AZD-2014の併用効果2016

    • Author(s)
      関原和正、田部陽子
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2016-10-06
    • Data Source
      KAKENHI-PROJECT-16K19855
  • [Presentation] マントル細胞リンパ腫のエネルギー代謝と生存シグナルを標的としたmTORおよびXPO1核外輸送シグナルの同時阻害効果2016

    • Author(s)
      関原和正、斉藤香里、三井田孝、田部陽子
    • Organizer
      第4回がんと代謝研究会
    • Place of Presentation
      かごしま県民交流センター(鹿児島市)
    • Year and Date
      2016-07-07
    • Data Source
      KAKENHI-PROJECT-16K19855
  • [Presentation] 低線量放射線が肥満細胞に及ぼす影響ープロテオミクスを用いた検討ー2016

    • Author(s)
      河島陽来、関原和正、斉藤香里、田部陽子、林宣宏
    • Organizer
      日本放射線影響学会第59回大会
    • Place of Presentation
      JMSアステールプラザ(広島市)
    • Year and Date
      2016-10-26
    • Data Source
      KAKENHI-PROJECT-16K19855
  • 1.  平山 亮一 (90435701)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 6 results
  • 2.  氷室 秀知 (90772567)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 7 results
  • 3.  HOSHINO Daisuke
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 4.  齋藤 菜緒
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 5.  田部 陽子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results
  • 6.  三井田 孝
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results
  • 7.  菅沼 伸康
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 8.  中山 博貴
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 9.  ニヨンサバ フランソワ
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 10.  中島 慎太郎
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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