Fujie Tomoya 藤江智也

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FUJIE Tomoya 藤江智也

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Researcher Number	20780886
Other IDs	https://orcid.org/0000-0002-5793-9401
Affiliation (Current)	2026: 東京理科大学, 薬学部薬学科, 講師
Affiliation (based on the past Project Information) *help	2023 – 2025: 東京理科大学, 薬学部薬学科, 講師 2018 – 2021: 東邦大学, 薬学部, 講師
Review Section/Research Field	Principal Investigator Basic Section 63030:Chemical substance influence on environment-related / Basic Section 58020:Hygiene and public health-related: including laboratory approach / Basic Section 47030:Pharmaceutical hygiene and biochemistry-related Except Principal Investigator Medium-sized Section 58:Society medicine, nursing, and related fields / Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
Keywords	Principal Investigator 細胞毒性 / 血管毒性 / 重金属毒性 / 内皮細胞 / カドミウム / 重金属 / メカノセンサー / メカニカルストレス / ヘパラン硫酸プロテオグリカン / プロテオグリカン … More / ATP / 鉛 / メタロチオネイン / 金属輸送体 / 血管内皮細胞 … More Except Principal Investigator ゼブラフィッシュ / バイオマーカー / 有機フッ素化合物 / PFAS / バイオオルガノメタリクス / プラスミノーゲンアクチベーターインヒビター1型 / 線溶 / 鉛 / PAI-1 / t-PA / ハイブリッド分子 / プラスミノーゲンアクチベーターインヒビター1型 / 組織型プラスミノーゲンアクチベーター / プラスミノーゲンアクチベータインヒビター1 / 線溶系 / 血管内皮細胞 / カドミウム Less

重金属に曝露された血管内皮細胞の擬似的メカニカルストレスとその毒性学的意義Principal Investigator
- Principal Investigator
  
  藤江智也
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 63030:Chemical substance influence on environment-related
- Research Institution
  Tokyo University of Science
Exploration and identification of biomarkers that serve as exposure indicators and health hazard indicators for per- and polyfluoroalkyl compounds, PFAS
- Principal Investigator
  
  鍜冶利幸
- Project Period (FY)
  2025 – 2026
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 58:Society medicine, nursing, and related fields
- Research Institution
  Tokyo University of Science
Toxicological modulation of vascular endothelial toxicity induced by heavy metals in response to environmental changes in vascular lesions and its mechanistic analysisPrincipal Investigator
- Principal Investigator
  
  Fujie Tomoya
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 58020:Hygiene and public health-related: including laboratory approach
- Research Institution
  Tokyo University of Science
Clarification underlying the molecules and mechanisms responsible for heavy metal interactions in vascular endothelial cellsPrincipal Investigator
- Principal Investigator
  
  FUJIE Tomoya
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Toho University
Intracellular signal pathways that are involved in the regulation of fibrinolysis by vascular endothelial cells
- Principal Investigator
  
  YAMAMOTO Chika
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Toho University

All 2025 2024 2023 2022 2021 2020 2019

All Journal Article Presentation

[Journal Article] Cadmium Induces Vascular Endothelial Cell Detachment by Downregulating Claudin-5 and ZO-1 Levels2024
- Author(s)
  Hara Takato、Asatsu Mayuka、Yamagishi Tatsuya、Ohata Chinami、Funatsu Hitomi、Takahashi Yuzuki、Shirai Misaki、Nakata Chiaki、Katayama Haruka、Kaji Toshiyuki、Fujie Tomoya、Yamamoto Chika
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 25 Issue: 20 Pages: 11035-11035
- DOI
  10.3390/ijms252011035
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K17355, KAKENHI-PROJECT-23K16312
[Journal Article] Zrt- and Irt-like protein 8 (ZIP8) and metallothionein aid in zinc protection of cultured vascular endothelial cells against cadmium cytotoxicity2024
- Author(s)
  Fujie Tomoya、Uehara Akane、Ito Keisuke、Hara Takato、Yamamoto Chika、Kaji Toshiyuki
- Journal Title
  
  Fundamental Toxicological Sciences
  
  Volume: 11 Issue: 4 Pages: 205-213
- DOI
  10.2131/fts.11.205
- ISSN
  2189-115X
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K17355, KAKENHI-PROJECT-23K16312
[Journal Article] Protection of cultured vascular endothelial cells against cadmium cytotoxicity by simultaneous treatment or pretreatment with manganese2024
- Author(s)
  Fujie Tomoya、Ando Reika、Abe Momoka、Ichida Natsumi、Ito Keisuke、Hara Takato、Yamamoto Chika、Kaji Toshiyuki
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 49 Issue: 8 Pages: 349-358
- DOI
  10.2131/jts.49.349
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K17355, KAKENHI-PROJECT-23K16312
[Journal Article] Induction of ZIP8, a ZIP transporter, via NF-κB signaling by the activation of IκBα and JNK signaling in cultured vascular endothelial cells exposed to cadmium2022
- Author(s)
  Fujie Tomoya、Ito Keisuke、Ozaki Yusuke、Takahashi Suzuka、Yamamoto Chika、Kaji Toshiyuki
- Journal Title
  
  Toxicology and Applied Pharmacology
  
  Volume: 434 Pages: 115802-115802
- DOI
  10.1016/j.taap.2021.115802
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16361
[Journal Article] Cadmium induces plasminogen activator inhibitor-1 via Smad2/3 signaling pathway in human endothelial EA.hy926 cells2021
- Author(s)
  Hara Takato、Sakuma Miki、Fujie Tomoya、Kaji Toshiyuki、Yamamoto Chika
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 46 Issue: 5 Pages: 249-253
- DOI
  10.2131/jts.46.249
- NAID
  130008033315
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06638
[Journal Article] Fibroblast Growth Factor-2 Upregulates Reactive Sulfur Species Production <i>via</i> ERK1/2 Signal-Mediated Cystathionine γ-Lyase Induction in Cultured Bovine Aortic Endothelial Cells2021
- Author(s)
  Takahashi, M., Kubota, T., Fujie, T., Shinkai, Y., Kumagai, Y., Nakano, T., Hara, T., Yamamoto, C.* and Kaji, T.*
- Journal Title
  
  BPB Reports
  
  Volume: 4 Issue: 6 Pages: 175-181
- DOI
  10.1248/bpbreports.4.6_175
- NAID
  130008115933
- ISSN
  2434-432X
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07089, KAKENHI-PROJECT-19K16361, KAKENHI-PROJECT-19K19418, KAKENHI-PROJECT-18H05293, KAKENHI-PROJECT-20H04340
[Journal Article] Synthesis of reactive sulfur species in cultured vascular endothelial cells after exposure to TGF-β1: Induction of cystathionine γ-lyase and cystathionine β-synthase expression mediated by the ALK5-Smad2/3/4 and ALK5-Smad2/3-ATF4 pathways2021
- Author(s)
  37.Takahashi, M., Fujie, T., Nakano, T., Hara, T., Shinkai, Y., Takasawa, R., Hara, Y., Kumagai, Y., Yamamoto, C.* and Kaji, T.*
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 21 Pages: 11762-11762
- DOI
  10.3390/ijms222111762
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07089, KAKENHI-PROJECT-19K16361, KAKENHI-PROJECT-18H05293, KAKENHI-PROJECT-20H04340
[Journal Article] TGF-β1 Potentiates the Cytotoxicity of Cadmium by Induction of a Metal Transporter, ZIP8, Mediated by the ALK5-Smad2/3 and ALK5-Smad3-p38 MAPK Signal Pathways in Cultured Vascular Endothelial Cells2021
- Author(s)
  Ito Keisuke、Fujie Tomoya、Shimomura Masahiro、Nakano Tsuyoshi、Yamamoto Chika、Kaji Toshiyuki
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 1 Pages: 448-448
- DOI
  10.3390/ijms23010448
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16361
[Journal Article] Zn(II)2,9-dimethyl-1,10-phenanthroline stimulates cultured bovine aortic endothelial cell proliferation2020
- Author(s)
  Takehiro Nakamura, Eiko Yoshida, Takato Hara, Tomoya Fujie, Chika Yamamoto, Yasuyuki Fujiwara, Fumihiko Ogata, Naohito Kawasaki, Ryo Takita, Masanobu Uchiyama and Toshiyuki Kaji
- Journal Title
  
  RSC Advances
  
  Volume: 10 Issue: 69 Pages: 42327-42337
- DOI
  10.1039/d0ra06731h
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07089, KAKENHI-PROJECT-19K16361, KAKENHI-PROJECT-17H06173
[Journal Article] Induction of metallothionein isoforms in cultured bovine aortic endothelial cells exposed to cadmium2020
- Author(s)
  Tomoya Fujie, Yusuke Ozaki, Fukuta Takenaka, Misaki Nishio, Takato Hara, Yasuyuki Fujiwara, Chika Yamamoto, and Toshiyuki Kaji
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 45 Issue: 12 Pages: 801-806
- DOI
  10.2131/jts.45.801
- NAID
  130007948808
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07089, KAKENHI-PROJECT-19K16361
[Journal Article] Transcriptional induction of cystathionine γ-lyase, a reactive sulfur-producing enzyme, by copper diethyldithiocarbamate in cultured vascular endothelial cells2020
- Author(s)
  Tomoya Fujie, Akane Takahashi, Musubu Takahashi, Takato Hara, Asuka Soyama, Kosho Makino, Hideyo Takahashi, Chika Yamamoto, Yoshito Kumagai, Hiroshi Naka and Toshiyuki Kaji
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 21 Issue: 17 Pages: 6053-6053
- DOI
  10.3390/ijms21176053
- NAID
  120007163377
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07089, KAKENHI-PROJECT-19K16361, KAKENHI-PROJECT-19K16454, KAKENHI-PROJECT-18H05293
[Presentation] 血管内皮細胞におけるカドミウム毒性に対する感受性修飾因子による相互作用2025
- Author(s)
  藤江智也，鍜冶利幸
- Organizer
  日本薬学会第145年会
- Invited
- Data Source
  KAKENHI-PROJECT-23K16312
[Presentation] ATPによるプリン受容体を介した内皮細胞のパールカン発現の抑制2024
- Author(s)
  池内璃仁，中野毅，原崇人，北畠和己，月本光俊，山本千夏，藤江智也，鍜冶利幸
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-23K16312
[Presentation] ATP suppresses the expression of perlecan, a extracellular heparan sulfate proteoglycan, via P2Y2 receptor in cultured vascular endothelial cells2024
- Author(s)
  Lihito Ikeuchi, Tsuyoshi Nakano, Takato Hara, Kazuki Kitabatake, Chika Yamamoto, Mitsutoshi Tsukimoto, Tomoya Fujie, Toshiyuki Kaji
- Organizer
  10th International Postgraduate Conference on Pharmaceutical Sciences 2024 (iPOPs2024)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K16312
[Presentation] ATPによるP2Y2-Aktシグナルを介した内皮細胞のパールカン発現の抑制2024
- Author(s)
  池内璃仁，中野毅，原崇人，北畠和己，月本光俊，山本千夏，藤江智也，鍜冶利幸
- Organizer
  第51回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-23K16312
[Presentation] カドミウムの内皮細胞傷害に対するインテグリン発現抑制の関与2024
- Author(s)
  市田夏海，佐山健太郎，原崇人，鍜冶利幸，山本千夏，藤江智也
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-23K16312
[Presentation] 細胞外ATPによるP2Y2R-Aktシグナルを介した血管内皮細胞ヘパラン硫酸プロテオグリカン大型分子種パールカンの発現抑制2024
- Author(s)
  池内璃仁，中野毅，原崇人，北畠和己，山本千夏，月本光俊，藤江智也，鍜冶利幸
- Organizer
  フォーラム2024：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-23K16312
[Presentation] アデニン代謝物による血管内皮細胞のヘパラン硫酸プロテオグリカンの転写調節2023
- Author(s)
  池内璃仁，中野毅，原崇人，北畠和己，山本千夏，月本光俊，藤江智也，鍜冶利幸
- Organizer
  第50回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-23K16312
[Presentation] カドミウムによる血管内皮細胞層の傷害に対するインテグリン発現抑制の関与2023
- Author(s)
  市田夏海，佐山健太郎，原崇人，鍜冶利幸，山本千夏，藤江智也
- Organizer
  フォーラム2023：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-23K16312
[Presentation] カドミウムによる内皮細胞毒性に対するインテグリン発現の関与2023
- Author(s)
  市田夏海，佐山健太郎，原崇人，鍜冶利幸，山本千夏，藤江智也
- Organizer
  第50回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-23K16312
[Presentation] カドミウムによる血管内皮細胞層の傷害に対するインテグリン発現抑制の関与2023
- Author(s)
  市田夏海，佐山健太郎，原崇人，鍜冶利幸，山本千夏，藤江智也
- Organizer
  メタルバイオサイエンス研究会2023
- Data Source
  KAKENHI-PROJECT-23K16312
[Presentation] メチル水銀による血管内皮細胞のEGFR-p38 MAPK-PKA経路を介したZIP8発現誘導はカドミウムの細胞内蓄積を増大する2022
- Author(s)
  伊藤佳祐，吉沢征生，中野毅，藤江智也，山本千夏，鍜冶利幸
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-19K16361
[Presentation] ヒト血管内皮細胞株EA.hy926細胞におけるカドミウムによるPAI-1発現誘導メカニズムの探索2021
- Author(s)
  原崇人，佐久間美岐，藤江智也，鍜冶利幸，山本千夏
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-18K06638
[Presentation] カドミウムによる血管内皮細胞のインテグリン発現の抑制2021
- Author(s)
  佐山健太郎，藤江智也，原崇人，鍜冶利幸，山本千夏
- Organizer
  フォーラム2021：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-19K16361
[Presentation] TGF-β1によるカドミウムの内皮細胞毒性の増強とそのメカニズムとしての金属輸送体ZIP8の発現誘導2021
- Author(s)
  伊藤佳祐，藤江智也，下村正裕，山本千夏，鍜冶利幸
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-19K16361
[Presentation] 血管内皮細胞におけるカドミウム毒性に対するメタロチオネインの役割2021
- Author(s)
  藤江智也，鍜冶利幸，山本千夏
- Organizer
  第48回日本毒性学会学術年会
- Invited
- Data Source
  KAKENHI-PROJECT-19K16361
[Presentation] 血管内皮細胞においてt-PA発現を誘導するターピリジン亜鉛錯体2021
- Author(s)
  藤江智也，原崇人，伊藤愛，鍜冶利幸，山本千夏
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-18K06638
[Presentation] 血管内皮細胞においてメチル水銀はEGFR-p38 MAPK-PKA経路を活性化して金属輸送体ZIP8の発現を誘導する2021
- Author(s)
  吉沢征生，伊藤佳祐，藤江智也，山本千夏，鍜冶利幸
- Organizer
  第48回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-19K16361
[Presentation] メチル水銀はEGFR-p38 MAPK-PKA経路の活性化を介して血管内皮細胞ZIP8の発現を誘導する2021
- Author(s)
  吉沢征生，伊藤佳祐，中野毅，藤江智也，山本千夏，鍜冶利幸
- Organizer
  メタルバイオサイエンス研究会2021
- Data Source
  KAKENHI-PROJECT-19K16361
[Presentation] カドミウムの内皮細胞毒性は転写因子NF-κBの活性化が介在する金属輸送体ZIP8の誘導によって増強される2021
- Author(s)
  伊藤佳祐，藤江智也，尾﨑勇介，中野毅，山本千夏，鍜冶利幸
- Organizer
  メタルバイオサイエンス研究会2021
- Data Source
  KAKENHI-PROJECT-19K16361
[Presentation] カドミウムによるヒト血管内皮細胞株EA.hy926細胞のPAI-1発現の誘導2020
- Author(s)
  原崇人，佐久間美岐，藤江智也，鍜冶利幸，山本千夏
- Organizer
  生命金属に関する合同年会（ConMetal 2020）
- Data Source
  KAKENHI-PROJECT-18K06638
[Presentation] 血管内皮細胞におけるカドミウムおよび鉛の相互作用2019
- Author(s)
  藤江智也，忍勇太朗，山本千夏，鍜冶利幸
- Organizer
  メタルバイオサイエンス研究会2019
- Data Source
  KAKENHI-PROJECT-19K16361
[Presentation] 血管内皮細胞におけるカドミウムと他の重金属の相互作用2019
- Author(s)
  藤江智也，山本千夏，鍜冶利幸
- Organizer
  第46回日本毒性学会学術年会
- Invited
- Data Source
  KAKENHI-PROJECT-19K16361

1. 原崇人 (90805681)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
2. YAMAMOTO Chika (70230571)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
3. 鍜冶利幸 (90204388)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 鍛冶利幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results

Fujie Tomoya 藤江 智也

FUJIE Tomoya 藤江 智也

Research Projects

Research Products

Co-Researchers

重金属に曝露された血管内皮細胞の擬似的メカニカルストレスとその毒性学的意義Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Exploration and identification of biomarkers that serve as exposure indicators and health hazard indicators for per- and polyfluoroalkyl compounds, PFAS

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Toxicological modulation of vascular endothelial toxicity induced by heavy metals in response to environmental changes in vascular lesions and its mechanistic analysisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Clarification underlying the molecules and mechanisms responsible for heavy metal interactions in vascular endothelial cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Intracellular signal pathways that are involved in the regulation of fibrinolysis by vascular endothelial cells

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Cadmium Induces Vascular Endothelial Cell Detachment by Downregulating Claudin-5 and ZO-1 Levels2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Zrt- and Irt-like protein 8 (ZIP8) and metallothionein aid in zinc protection of cultured vascular endothelial cells against cadmium cytotoxicity2024

Author(s)

Journal Title

DOI

ISSN

Language

Data Source

[Journal Article] Protection of cultured vascular endothelial cells against cadmium cytotoxicity by simultaneous treatment or pretreatment with manganese2024

Author(s)

Journal Title

DOI

ISSN

Language

Data Source

[Journal Article] Induction of ZIP8, a ZIP transporter, via NF-κB signaling by the activation of IκBα and JNK signaling in cultured vascular endothelial cells exposed to cadmium2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cadmium induces plasminogen activator inhibitor-1 via Smad2/3 signaling pathway in human endothelial EA.hy926 cells2021

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Fibroblast Growth Factor-2 Upregulates Reactive Sulfur Species Production <i>via</i> ERK1/2 Signal-Mediated Cystathionine γ-Lyase Induction in Cultured Bovine Aortic Endothelial Cells2021

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Synthesis of reactive sulfur species in cultured vascular endothelial cells after exposure to TGF-β1: Induction of cystathionine γ-lyase and cystathionine β-synthase expression mediated by the ALK5-Smad2/3/4 and ALK5-Smad2/3-ATF4 pathways2021

Author(s)

Journal Title

DOI

Data Source

Fujie Tomoya 藤江智也

FUJIE Tomoya 藤江智也