Kamiya Yusuke 神矢佑輔

Researcher Number	20802945
Other IDs	https://orcid.org/0000-0002-1100-7318
Affiliation (Current)	2026: 琉球大学, 病院, 薬剤師
Affiliation (based on the past Project Information) *help	2019 – 2020: 昭和薬科大学, 薬学部, 特任助教
Review Section/Research Field	Principal Investigator Basic Section 47060:Clinical pharmacy-related
Keywords	Principal Investigator 一般化学物質 / 生理学的薬物動態モデル / 肝毒性評価 / 化学物質 / 薬物動態予測 / 消化管吸収性

Evaluation of hepatotoxicity of industrial chemicals based on intestinal absorption and physiologically based pharmacokinetic modellingPrincipal Investigator
- Principal Investigator
  
  Kamiya Yusuke
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Showa Pharmaceutical University

All 2021 2020 2019

All Journal Article Presentation

[Journal Article] In Silico Prediction of Input Parameters for Simplified Physiologically Based Pharmacokinetic Models for Estimating Plasma, Liver, and Kidney Exposures in Rats after Oral Doses of 246 Disparate Chemicals2021
- Author(s)
  Kamiya Yusuke、Handa Kentaro、Miura Tomonori、Yanagi Mayu、Shigeta Kazuki、Hina Shiori、Shimizu Makiko、Kitajima Masato、Shono Fumiaki、Funatsu Kimito、Yamazaki Hiroshi
- Journal Title
  
  Chemical Research in Toxicology
  
  Volume: 34 Issue: 2 Pages: 507-513
- DOI
  10.1021/acs.chemrestox.0c00336
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16422, KAKENHI-PROJECT-20K07164
[Journal Article] Hepatotoxicological potential of P-toluic acid in humanised-liver mice investigated using simplified physiologically based pharmacokinetic models2021
- Author(s)
  Miura Tomonori、Kamiya Yusuke、Uehara Shotaro、Murayama Norie、Shimizu Makiko、Suemizu Hiroshi、Yamazaki Hiroshi
- Journal Title
  
  Xenobiotica
  
  Volume: － Issue: 6 Pages: 1-7
- DOI
  10.1080/00498254.2021.1908643
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16422, KAKENHI-PROJECT-20J21210, KAKENHI-PROJECT-20K07139
[Journal Article] Different Hepatic Concentrations of Bromobenzene, 1,2-Dibromobenzene, and 1,4-Dibromobenzene in Humanized-Liver Mice Predicted Using Simplified Physiologically Based Pharmacokinetic Models as Putative Markers of Toxicological Potential2020
- Author(s)
  Miura Tomonori、Shimizu Makiko、Uehara Shotaro、Yoshizawa Manae、Nakano Ayane、Yanagi Mayu、Kamiya Yusuke、Murayama Norie、Suemizu Hiroshi、Yamazaki Hiroshi
- Journal Title
  
  Chemical Research in Toxicology
  
  Volume: 33 Issue: 12 Pages: 3048-3053
- DOI
  10.1021/acs.chemrestox.0c00387
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07164, KAKENHI-PROJECT-20J21210, KAKENHI-PROJECT-19K16422
[Journal Article] Increased plasma concentrations of an antidyslipidemic drug pemafibrate co-administered with rifampicin or cyclosporine A in cynomolgus monkeys genotyped for the organic anion transporting polypeptide 1B12020
- Author(s)
  Ogawa Shin-ichiro、Shimizu Makiko、Kamiya Yusuke、Uehara Shotaro、Suemizu Hiroshi、Yamazaki Hiroshi
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 35 Issue: 4 Pages: 354-360
- DOI
  10.1016/j.dmpk.2020.03.005
- NAID
  50014558608
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16422
[Journal Article] Metabolic Profiles of Tetrabromobisphenol A in Humans Extrapolated from Humanized-Liver Mouse Data Using a Simplified Physiologically Based Pharmacokinetic Model2020
- Author(s)
  Miura Tomonori、Uehara Shotaro、Shigeta Kazuki、Yoshizawa Manae、Kamiya Yusuke、Murayama Norie、Shimizu Makiko、Suemizu Hiroshi、Yamazaki Hiroshi
- Journal Title
  
  Chemical Research in Toxicology
  
  Volume: 34 Issue: 2 Pages: 522-528
- DOI
  10.1021/acs.chemrestox.0c00358
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16422, KAKENHI-PROJECT-20K06463, KAKENHI-PROJECT-20K07164
[Journal Article] Metabolic profiles of coumarin in human plasma extrapolated from a rat data set with a simplified physiologically based pharmacokinetic model2020
- Author(s)
  47.Miura T, Kamiya Y, Hina S, Kobayashi Y, Murayama N, Shimizu M, Yamazaki H.
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 45 Issue: 11 Pages: 695-700
- DOI
  10.2131/jts.45.695
- NAID
  130007935150
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07139, KAKENHI-PROJECT-20J21210, KAKENHI-PROJECT-19K16422
[Journal Article] Plasma, liver, and kidney exposures in rats after oral doses of industrial chemicals predicted using physiologically based pharmacokinetic models: A case study of perﬂuorooctane sulfonic acid2020
- Author(s)
  Kamiya Yusuke、Yanagi Mayu、Hina Shiori、Shigeta Kazuki、Miura Tomonori、Yamazaki Hiroshi
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 45 Issue: 12 Pages: 763-767
- DOI
  10.2131/jts.45.763
- NAID
  130007948827
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16422
[Journal Article] Physiologically Based Pharmacokinetic Models Predicting Renal and Hepatic Concentrations of Industrial Chemicals after Virtual Oral Doses in Rats2020
- Author(s)
  Kamiya Yusuke、Otsuka Shohei、Miura Tomonori、Yoshizawa Manae、Nakano Ayane、Iwasaki Miyu、Kobayashi Yui、Shimizu Makiko、Kitajima Masato、Shono Fumiaki、Funatsu Kimito、Yamazaki Hiroshi
- Journal Title
  
  Chemical Research in Toxicology
  
  Volume: 33 Issue: 7 Pages: 1736-1751
- DOI
  10.1021/acs.chemrestox.0c00009
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16422
[Journal Article] Determination and prediction of permeability across intestinal epithelial cell monolayer of a diverse range of industrial chemicals/drugs for estimation of oral absorption as a putative marker of hepatotoxicity.2020
- Author(s)
  .Kamiya, Y., Takaku, H., Yamada, R., Akase, C., Abe, Y., Sekiguchi, Y., Murayama, N., Shimizu, M., Kitajima, M., Shono, F., Funatsu, K., and Yamazaki, H.
- Journal Title
  
  Toxicol. Rep.
  
  Volume: 149 Pages: 149-154
- DOI
  10.1016/j.toxrep.2020.01.004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07139, KAKENHI-PROJECT-19K16422
[Presentation] 培養ヒトおよびラット腸細胞を用いた一般化学物質の膜透過性および動物肝無毒性指標の関連2020
- Author(s)
  神矢佑輔、大村明日香、關口佑子、赤瀨千聡、阿部雄人、庄野文章、山崎浩史
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-19K16422
[Presentation] 多様な一般化学物質および医薬品の培養ヒト小腸上皮膜透過係数の予測2020
- Author(s)
  關口佑子、神矢佑輔、大村明日香、赤瀨千聡、阿部雄人、庄野文章、船津公人、山崎浩史
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-19K16422
[Presentation] 一般化学物質のラット血中濃度推移情報と生理学的薬物動態モデルを活用した予測肝中濃度と臓器毒性2020
- Author(s)
  村山典恵、柳麻由、岩崎美友、小林由惟、中野彩音、三浦智徳、神矢佑輔、庄野文章、山崎浩史
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-19K16422
[Presentation] 腎を独立させた生理学的薬物動態モデルで予測した一般化学物質のラット組織中濃度と臓器毒性2020
- Author(s)
  重田和樹、村山典恵、吉沢愛映、大西潮、大塚昌平、神矢佑輔、庄野文章、山崎浩史
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-19K16422
[Presentation] Determination of permeability across Caco-2 cell monolayer and development of predictable equations for oral absorbability of general chemical substances2019
- Author(s)
  Kamiya Yusuke、Takaku Hiroka、Yamada Rio、Yamazaki Hiroshi
- Organizer
  12th International ISSX Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16422

1. 清水万紀子

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
2. 村山典惠

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
3. 山崎浩史

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Kamiya Yusuke 神矢 佑輔

Research Projects

Research Products

Co-Researchers

Evaluation of hepatotoxicity of industrial chemicals based on intestinal absorption and physiologically based pharmacokinetic modellingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] In Silico Prediction of Input Parameters for Simplified Physiologically Based Pharmacokinetic Models for Estimating Plasma, Liver, and Kidney Exposures in Rats after Oral Doses of 246 Disparate Chemicals2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hepatotoxicological potential of P-toluic acid in humanised-liver mice investigated using simplified physiologically based pharmacokinetic models2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Different Hepatic Concentrations of Bromobenzene, 1,2-Dibromobenzene, and 1,4-Dibromobenzene in Humanized-Liver Mice Predicted Using Simplified Physiologically Based Pharmacokinetic Models as Putative Markers of Toxicological Potential2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Increased plasma concentrations of an antidyslipidemic drug pemafibrate co-administered with rifampicin or cyclosporine A in cynomolgus monkeys genotyped for the organic anion transporting polypeptide 1B12020

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Metabolic Profiles of Tetrabromobisphenol A in Humans Extrapolated from Humanized-Liver Mouse Data Using a Simplified Physiologically Based Pharmacokinetic Model2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Metabolic profiles of coumarin in human plasma extrapolated from a rat data set with a simplified physiologically based pharmacokinetic model2020

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Plasma, liver, and kidney exposures in rats after oral doses of industrial chemicals predicted using physiologically based pharmacokinetic models: A case study of perﬂuorooctane sulfonic acid2020

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Physiologically Based Pharmacokinetic Models Predicting Renal and Hepatic Concentrations of Industrial Chemicals after Virtual Oral Doses in Rats2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Determination and prediction of permeability across intestinal epithelial cell monolayer of a diverse range of industrial chemicals/drugs for estimation of oral absorption as a putative marker of hepatotoxicity.2020

Author(s)

Journal Title

DOI

Data Source

[Presentation] 培養ヒトおよびラット腸細胞を用いた一般化学物質の膜透過性および動物肝無毒性指標の関連2020

Author(s)

Organizer

Data Source

[Presentation] 多様な一般化学物質および医薬品の培養ヒト小腸上皮膜透過係数の予測2020

Author(s)

Organizer

Data Source

[Presentation] 一般化学物質のラット血中濃度推移情報と生理学的薬物動態モデルを活用した予測肝中濃度と臓器毒性2020

Author(s)

Organizer

Data Source

[Presentation] 腎を独立させた生理学的薬物動態モデルで予測した一般化学物質のラット組織中濃度と臓器毒性2020

Author(s)

Organizer

Data Source

[Presentation] Determination of permeability across Caco-2 cell monolayer and development of predictable equations for oral absorbability of general chemical substances2019

Author(s)

Kamiya Yusuke 神矢佑輔