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Matsubara Sho  松原 翔

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Sho Matsubara  松原 翔

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Researcher Number 20825236
Affiliation (Current) 2026: 奈良県立医科大学, 医学部附属病院, 研究員
Affiliation (based on the past Project Information) *help 2019 – 2024: 奈良県立医科大学, 医学部附属病院, 研究員
Review Section/Research Field
Principal Investigator
Basic Section 56040:Obstetrics and gynecology-related
Except Principal Investigator
Basic Section 56040:Obstetrics and gynecology-related / Basic Section 50010:Tumor biology-related
Keywords
Principal Investigator
卵巣癌
Except Principal Investigator
子宮腺筋症 / 子宮内膜症 / 卵巣癌 / 癌化 / 酸化ストレス / 卵巣がん / 遺伝子発現プロファイル / MRI / 不妊症 … More / 過多月経 / 月経困難症 / TGF-β / 筋線維芽細胞 / Ⅱ型腺筋症 / Ⅰ型腺筋症 / KRAS遺伝子 / KRAS変異 / 2型子宮腺筋症 / 1型子宮腺筋症 / 子宮腺筋腫 / チョコレート嚢胞 / 近赤外線 / 鉄 / Adenomyosis / 抗腫瘍免疫 / 好中球増多 / 治療抵抗性 / 子宮癌 / 好中球 / 癌幹細胞 / MDSC / 婦人科がん / がん幹細胞 / 骨髄由来抑制細胞 / 子宮悪性腫瘍 / 免疫逃避機構 / 好中球細胞外トラップ / 細胞周期関連遺伝子 / PIK3CA / PIK3CA遺伝子変異 / synthetic lethality / ARID1A mutation / Cyclin-E1(CCNE1) / CCNE1 / Cyclin-E1 / ARID1A遺伝子変異 / 合成致死 / 卵巣明細胞癌 Less
  • Research Projects

    (7 results)
  • Research Products

    (30 results)
  • Co-Researchers

    (16 People)
  •  Differentiation of benign and malignant ovarian tumors using the novel tumor marker tissue factor pathway inhibitor 2Principal Investigator

    • Principal Investigator
      Sho Matsubara
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56040:Obstetrics and gynecology-related
    • Research Institution
      Nara Medical University
  •  Development of a classification method for uterine adenomyosis based on gene expression profiles

    • Principal Investigator
      Kana Iwai
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56040:Obstetrics and gynecology-related
    • Research Institution
      Nara Medical University
  •  The mechanism by which cancer stem-like cells mediated induction of NETosis in the malignant tumor of the uterus dysplaying neutrophilia.

    • Principal Investigator
      Mabuchi Seiji
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50010:Tumor biology-related
    • Research Institution
      Osaka International Cancer Institute
      Nara Medical University
  •  Establishment of a qualitative imaging method to non-invasively predict the severity of adenomyosis

    • Principal Investigator
      Kobayashi Hiroshi
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56040:Obstetrics and gynecology-related
    • Research Institution
      Nara Medical University
  •  Verification of the safety and effectiveness of a test for predicting malignant transformation of endometriosis

    • Principal Investigator
      Shigetomi Hiroshi
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56040:Obstetrics and gynecology-related
    • Research Institution
      Nara Medical University
  •  Search for synthetic lethal candidates for PIK3CA mutations

    • Principal Investigator
      Mika Nagayasu
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56040:Obstetrics and gynecology-related
    • Research Institution
      Nara Medical University
  •  The carcinogenesis of ovarian endometrioma due to redox environmentt

    • Principal Investigator
      Yuki Yamada
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56040:Obstetrics and gynecology-related
    • Research Institution
      Nara Medical University

All 2024 2023 2022 2021 2020 2019

All Journal Article Presentation

  • [Journal Article] An integral role of mitochondrial function in the pathophysiology of preeclampsia2024

    • Author(s)
      Kobayashi Hiroshi、Yoshimoto Chiharu、Matsubara Sho、Shigetomi Hiroshi、Imanaka Shogo
    • Journal Title

      Molecular Biology Reports

      Volume: 51 Issue: 1 Pages: 330-330

    • DOI

      10.1007/s11033-024-09285-z

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22K09549, KAKENHI-PROJECT-22K09576, KAKENHI-PROJECT-22K09643, KAKENHI-PROJECT-23K08806
  • [Journal Article] Rethinking the pathogenesis of endometriosis: Complex interactions of genomic, epigenetic, and environmental factors2024

    • Author(s)
      Kobayashi Hiroshi、Imanaka Shogo、Yoshimoto Chiharu、Matsubara Sho、Shigetomi Hiroshi
    • Journal Title

      Journal of Obstetrics and Gynaecology Research

      Volume: 50 Issue: 10 Pages: 1771-1784

    • DOI

      10.1111/jog.16089

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22K09549, KAKENHI-PROJECT-22K09576, KAKENHI-PROJECT-22K09643, KAKENHI-PROJECT-23K08806, KAKENHI-PROJECT-24K12605
  • [Journal Article] Molecular mechanism of autophagy and apoptosis in endometriosis: Current understanding and future research directions2024

    • Author(s)
      Kobayashi Hiroshi、Imanaka Shogo、Yoshimoto Chiharu、Matsubara Sho、Shigetomi Hiroshi
    • Journal Title

      Reproductive Medicine and Biology

      Volume: 23 Issue: 1 Pages: 12577-12577

    • DOI

      10.1002/rmb2.12577

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22K09549, KAKENHI-PROJECT-22K09576, KAKENHI-PROJECT-22K09643, KAKENHI-PROJECT-23K08806, KAKENHI-PROJECT-24K12605
  • [Journal Article] Role of autophagy and ferroptosis in the development of endometriotic cysts (Review)2024

    • Author(s)
      Kobayashi Hiroshi、Imanaka Shogo、Yoshimoto Chiharu、Matsubara Sho、Shigetomi Hiroshi
    • Journal Title

      International Journal of Molecular Medicine

      Volume: 54 Issue: 3 Pages: 78-78

    • DOI

      10.3892/ijmm.2024.5402

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22K09549, KAKENHI-PROJECT-22K09576, KAKENHI-PROJECT-22K09643, KAKENHI-PROJECT-23K08806, KAKENHI-PROJECT-24K12605
  • [Journal Article] Role of the mitophagy‐apoptosis axis in the pathogenesis of polycystic ovarian syndrome2024

    • Author(s)
      Kobayashi Hiroshi、Shigetomi Hiroshi、Matsubara Sho、Yoshimoto Chiharu、Imanaka Shogo
    • Journal Title

      Journal of Obstetrics and Gynaecology Research

      Volume: 50 Issue: 5 Pages: 775-792

    • DOI

      10.1111/jog.15916

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22K09549, KAKENHI-PROJECT-22K09576, KAKENHI-PROJECT-22K09643, KAKENHI-PROJECT-23K08806
  • [Journal Article] Current understanding of the pathogenesis of placenta accreta spectrum disorder with focus on mitochondrial function2024

    • Author(s)
      Kobayashi Hiroshi、Matsubara Sho、Yoshimoto Chiharu、Shigetomi Hiroshi、Imanaka Shogo
    • Journal Title

      Journal of Obstetrics and Gynaecology Research

      Volume: 50 Issue: 6 Pages: 929-940

    • DOI

      10.1111/jog.15936

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22K09549, KAKENHI-PROJECT-22K09576, KAKENHI-PROJECT-22K09643, KAKENHI-PROJECT-23K08806
  • [Journal Article] The role of tissue factor pathway inhibitor 2 in the coagulation and fibrinolysis system2023

    • Author(s)
      Hiroshi Kobayashi , Sho Matsubara, Shogo Imanaka
    • Journal Title

      J Obstet Gynaecol Res

      Volume: 49 Issue: 7 Pages: 1677-1683

    • DOI

      10.1111/jog.15660

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22K09550, KAKENHI-PROJECT-22K09576
  • [Journal Article] Tissue Factor Pathway Inhibitors as Potential Targets for Understanding the Pathophysiology of Preeclampsia2023

    • Author(s)
      Kobayashi Hiroshi、Matsubara Sho、Yoshimoto Chiharu、Shigetomi Hiroshi、Imanaka Shogo
    • Journal Title

      Biomedicines

      Volume: 11 Issue: 5 Pages: 1237-1237

    • DOI

      10.3390/biomedicines11051237

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K09576
  • [Journal Article] Tissue factor pathway inhibitor 2: Current understanding, challenges, and future perspectives2023

    • Author(s)
      Hiroshi Kobayashi, Sho Matsubara, Chiharu Yoshimoto, Hiroshi Shigetomi, Shogo Imanaka
    • Journal Title

      J Obstet Gynaecol Res

      Volume: 49 Issue: 11 Pages: 2575-2583

    • DOI

      10.1111/jog.15770

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22K09550, KAKENHI-PROJECT-22K09576
  • [Journal Article] The Comparison of Three Predictive Indexes to Discriminate Malignant Ovarian Tumors from Benign Ovarian Endometrioma: The Characteristics and Efficacy2022

    • Author(s)
      Yamanaka Shoichiro、Kawahara Naoki、Kawaguchi Ryuji、Waki Keita、Maehana Tomoka、Fukui Yosuke、Miyake Ryuta、Yamada Yuki、Kobayashi Hiroshi、Kimura Fuminori
    • Journal Title

      Diagnostics

      Volume: 12 Issue: 5 Pages: 1212-1212

    • DOI

      10.3390/diagnostics12051212

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K16819, KAKENHI-PROJECT-20K09648
  • [Journal Article] Tissue Factor Pathway Inhibitor 2: A Novel Biomarker for Predicting Asymptomatic Venous Thromboembolism in Patients with Epithelial Ovarian Cancer2022

    • Author(s)
      Yamanaka Shoichiro、Miyake Ryuta、Yamada Yuki、Kawaguchi Ryuji、Ootake Norihisa、Myoba Shohei、Kobayashi Hiroshi
    • Journal Title

      Gynecologic and Obstetric Investigation

      Volume: 87 Issue: 2 Pages: 133-140

    • DOI

      10.1159/000524804

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22K09576, KAKENHI-PROJECT-20K09648
  • [Journal Article] Tissue factor pathway inhibitor 2 : A potential diagnostic marker for discriminating benign from malignant ovarian tumors2022

    • Author(s)
      Kobayashi H, Yamada Y, Kawaguchi R, Ootake N, Myoba S, Kimura F.
    • Journal Title

      J Obstet Gynaecol Res.

      Volume: 48 Issue: 9 Pages: 2442-2451

    • DOI

      10.1111/jog.15345

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K11292, KAKENHI-PROJECT-22K09576, KAKENHI-PROJECT-20K09648
  • [Journal Article] Understanding the molecular mechanisms of macrophage polarization and metabolic reprogramming in endometriosis: A narrative review2022

    • Author(s)
      Kobayashi Hiroshi、Imanaka Shogo
    • Journal Title

      Reproductive Medicine and Biology

      Volume: 21 Issue: 1

    • DOI

      10.1002/rmb2.12488

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22K09549, KAKENHI-PROJECT-20K09648
  • [Journal Article] Revisiting therapeutic strategies for ovarian cancer by focusing on redox homeostasis (Review)2022

    • Author(s)
      Kobayashi Hiroshi、Imanaka Shogo、Shigetomi Hiroshi
    • Journal Title

      Oncology Letters

      Volume: 23 Issue: 3 Pages: 80-80

    • DOI

      10.3892/ol.2022.13200

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22K09549, KAKENHI-PROJECT-20K09648
  • [Journal Article] The Endometriotic Neoplasm Algorithm for Risk Assessment (e-NARA) Index Sheds Light on the Discrimination of Endometriosis-Associated Ovarian Cancer from Ovarian Endometrioma.2022

    • Author(s)
      Kawahara N, Kawaguchi R, Maehana T, Yamanaka S, Yamada Y, Kobayashi H, Kimura F.
    • Journal Title

      Biomedicines.

      Volume: 10(11) Issue: 11 Pages: 2683-2683

    • DOI

      10.3390/biomedicines10112683

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K16819, KAKENHI-PROJECT-20K09648
  • [Journal Article] Reprogramming of glucose metabolism of cumulus cells and oocytes and its therapeutic significance2022

    • Author(s)
      Imanaka Shogo、Shigetomi Hiroshi、Kobayashi Hiroshi
    • Journal Title

      Reproductive Sciences

      Volume: 29 Issue: 3 Pages: 653-667

    • DOI

      10.1007/s43032-021-00505-6

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22K09549, KAKENHI-PROJECT-20K09648
  • [Journal Article] Revisiting estrogen-dependent signaling pathways in endometriosis: Potential targets for non-hormonal therapeutics2021

    • Author(s)
      Kobayashi Hiroshi、Kimura Mai、Maruyama Sachiyo、Nagayasu Mika、Imanaka Shogo
    • Journal Title

      European Journal of Obstetrics & Gynecology and Reproductive Biology

      Volume: 258 Pages: 103-110

    • DOI

      10.1016/j.ejogrb.2020.12.044

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K09647
  • [Journal Article] Clinicopathological features of different subtypes in adenomyosis: Focus on early lesions2021

    • Author(s)
      Kobayashi Hiroshi、Matsubara Sho、Imanaka Shogo
    • Journal Title

      PLOS ONE

      Volume: 16 Issue: 7 Pages: e0254147-e0254147

    • DOI

      10.1371/journal.pone.0254147

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K09547
  • [Journal Article] A delicate redox balance between iron and heme oxygenase-1 as an essential biological feature of endometriosis2021

    • Author(s)
      Imanaka Shogo、Yamada Yuki、Kawahara Naoki、Kobayashi Hiroshi
    • Journal Title

      Archives of Medical Research

      Volume: 1 Issue: 6 Pages: 641-647

    • DOI

      10.1016/j.arcmed.2021.03.006

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K09647, KAKENHI-PROJECT-18K09269
  • [Journal Article] Tissue factor pathway inhibitor 2 as a serum marker for diagnosing asymptomatic venous thromboembolism in patients with epithelial ovarian cancer and positive D?dimer results2021

    • Author(s)
      Miyake Ryuta、Yamada Yuki、Yamanaka Shoichiro、Kawaguchi Ryuji、Ootake Norihisa、Myoba Shohei、Kobayashi Hiroshi
    • Journal Title

      Molecular and Clinical Oncology

      Volume: 16 Issue: 2 Pages: 1-5

    • DOI

      10.3892/mco.2021.2479

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K10488, KAKENHI-PROJECT-22K09576
  • [Journal Article] Nonhormonal Treatment for Endometriosis Focusing on Redox Imbalance2021

    • Author(s)
      Nagayasu Mika、Imanaka Shogo、Kimura Mai、Maruyama Sachiyo、Kobayashi Hiroshi
    • Journal Title

      Gynecologic and Obstetric Investigation

      Volume: 1 Issue: 1-2 Pages: 1-12

    • DOI

      10.1159/000512628

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K09647
  • [Journal Article] Relationship between magnetic resonance imaging‐based classification of adenomyosis and disease severity2021

    • Author(s)
      Kobayashi Hiroshi、Matsubara Sho、Imanaka Shogo
    • Journal Title

      Journal of Obstetrics and Gynaecology Research

      Volume: 1 Issue: 7 Pages: 2251-2260

    • DOI

      10.1111/jog.14803

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K09647
  • [Journal Article] Relationship between Cyst Fluid Concentrations of Iron and Severity of Dysmenorrhea in Patients with Ovarian Endometrioma2021

    • Author(s)
      Imanaka Shogo、Maruyama Sachiyo、Kimura Mai、Nagayasu Mika、Kawahara Naoki、Kobayashi Hiroshi
    • Journal Title

      Gynecologic and Obstetric Investigation

      Volume: 1 Issue: 1-2 Pages: 1-8

    • DOI

      10.1159/000514972

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K09647
  • [Journal Article] A Classification Proposal for Adenomyosis Based on Magnetic Resonance Imaging2020

    • Author(s)
      Kobayashi Hiroshi、Matsubara Sho
    • Journal Title

      Gynecologic and Obstetric Investigation

      Volume: 85 Issue: 2 Pages: 118-126

    • DOI

      10.1159/000505690

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K09647
  • [Journal Article] Relationship between adenomyosis and endometriosis; Different phenotypes of a single disease?2020

    • Author(s)
      Maruyama Sachiyo、Imanaka Shogo、Nagayasu Mika、Kimura Mai、Kobayashi Hiroshi
    • Journal Title

      European Journal of Obstetrics & Gynecology and Reproductive Biology

      Volume: 253 Pages: 191-197

    • DOI

      10.1016/j.ejogrb.2020.08.019

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K09647
  • [Journal Article] GSK-3β mediates the effects of HNF-1β overexpression in ovarian clear cell carcinoma2020

    • Author(s)
      Kawahara Naoki、Mizutani Ayano、Matsubara Sho、Takeda Yoshinori、Kobayashi Hiroshi
    • Journal Title

      Experimental and Therapeutic Medicine

      Volume: 20 Issue: 5 Pages: 122-122

    • DOI

      10.3892/etm.2020.9250

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K09604, KAKENHI-PROJECT-20K09647
  • [Presentation] 酸化還元反応のバランス変化に基づく発癌仮説2021

    • Author(s)
      山田有紀,松原 翔,竹田善紀,河原直紀,川口龍二,岩渕拓也,小林 浩
    • Organizer
      第42回日本エンドメトリオーシス学会学術講演会
    • Invited
    • Data Source
      KAKENHI-PROJECT-18K09269
  • [Presentation] 卵巣子宮内膜症癌化の早期発見を目指した超音波機器の開発2020

    • Author(s)
      新納恵美子、松原 翔、吉元千陽、小林 浩
    • Organizer
      第41回日本エンドメトリオーシス学会学術講演会
    • Data Source
      KAKENHI-PROJECT-20K09648
  • [Presentation] 子宮内膜症の癌化におけるマクロファージの役割2020

    • Author(s)
      山田有紀,内山智子,竹田善紀,松原 翔,河原直紀,新納恵美子,川口龍二,小林 浩
    • Organizer
      第41回日本エンドメトリオーシス学会学術講演会
    • Data Source
      KAKENHI-PROJECT-18K09269
  • [Presentation] HNF-1beta 強発現を呈する卵巣明細胞癌に対する合成致死候補の検索2019

    • Author(s)
      河原直紀,竹田善紀, 松原 翔, 山田有紀,小林 浩
    • Organizer
      第24回日本病態プロテアーゼ学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K09809
  • 1.  Kobayashi Hiroshi (40178330)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 26 results
  • 2.  Yuki Yamada (20588537)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 4 results
  • 3.  川口 龍二 (50382289)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 4 results
  • 4.  吉元 千陽 (00526725)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  Mika Nagayasu (80623496)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  Mabuchi Seiji (00452441)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  Shigetomi Hiroshi (20433336)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  Kana Iwai (60588531)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  棚瀬 康仁 (20423915)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  小川 憲二 (60623494)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  河原 直紀 (70623495)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 12.  山中 彰一郎 (30866009)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  竹田 善紀 (50825239)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  三宅 龍太 (20866008)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  今中 聖悟 (20790306)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 10 results
  • 16.  UEKURI Chiharu
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 7 results

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