Kameda Hiraku 亀田啓

Researcher Number	20826127
Other IDs	https://orcid.org/0000-0003-1870-6688
Affiliation (Current)	2026: 北海道大学, 大学病院, 助教
Affiliation (based on the past Project Information) *help	2025: 北海道大学, 大学病院, 助教 2018 – 2022: 北海道大学, 大学病院, 助教
Review Section/Research Field	Principal Investigator Basic Section 54040:Metabolism and endocrinology-related / 0904:Internal medicine of the bio-information integration and related fields Except Principal Investigator Basic Section 58040:Forensics medicine-related
Keywords	Principal Investigator ニューロメジンB / 副腎皮質刺激ホルモン / 下垂体腫瘍 / クッシング病 / ニューロメジンB受容体 / ACTH / 下垂体腺腫 / 新規治療薬 Except Principal Investigator コレステロール / ステロイドホルモン / 低体温症

ステロイド生合成プロファイル解析による新たな低温症診断への可能性
- Principal Investigator
  
  神繁樹
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 58040:Forensics medicine-related
- Research Institution
  Hokkaido University
Neuromedin B receptor antagonists as a novel treatment for Cushing's disease.Principal Investigator
- Principal Investigator
  
  Kameda Hiraku
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Hokkaido University
Neuromedin B receptor antagonist as a new treatment for Cushing diseasePrincipal Investigator
- Principal Investigator
  
  Kameda Hiraku
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0904:Internal medicine of the bio-information integration and related fields
- Research Institution
  Hokkaido University

All 2023 2022 2021 2020 2019

All Journal Article Presentation

[Journal Article] The Impact of Multicultural Interfacility Video Case Conference: A Novel Education Model After the COVID Pandemic.2023
- Author(s)
  Takako Araki, Hiraku Kameda, Masaaki Yamamoto, Toru Tateno, Yasumasa Iwasaki, Run Yu, Constance Chik, Hiba Hashmi, Angela Radulescu, Lynn A Burmeister, Hidenori Fukuoka
- Journal Title
  
  J Endocr Soc.
  
  Volume: 7 Issue: 4 Pages: 1-6
- DOI
  10.1210/jendso/bvad023
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08907, KAKENHI-PROJECT-20K17481
[Journal Article] False Hypercortisolemia Due to Abnormal Albumin-Cortisol Binding in a Patient with Familial Dysalbuminemic Hyperthyroxinemia2022
- Author(s)
  Chiba Koki、Kameda Hiraku、Miya Aika、Nomoto Hiroshi、Cho Kyu Yong、Nakamura Akinobu、Jin Shigeki、Matoba Kotaro、Miyoshi Hideaki、Atsumi Tatsuya
- Journal Title
  
  Thyroid
  
  Volume: 32 Issue: 2 Pages: 219-220
- DOI
  10.1089/thy.2021.0460
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K17481
[Journal Article] Lymphocytic panhypophysitis and anti-rabphilin-3A antibody with pulmonary sarcoidosis2022
- Author(s)
  Takahashi Yuka、Kameda Hiraku、Miya Aika、Nomoto Hiroshi、Cho Kyu Yong、Nakamura Akinobu、Nishimura Hiroki、Kimura Hirokazu、Suzuki Masaru、Konno Satoshi、Shimizu Ai、Matsuno Yoshihiro、Okamoto Michinari、Motegi Hiroaki、Iwata Naoko、Fujisawa Haruki、Suzuki Atsushi、Sugimura Yoshihisa、Miyoshi Hideaki、Atsumi Tatsuya
- Journal Title
  
  Pituitary
  
  Volume: 25 Issue: 2 Pages: 321-327
- DOI
  10.1007/s11102-021-01200-0
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17724, KAKENHI-PROJECT-20K17481
[Journal Article] Dipeptidyl peptidase‐4 inhibitor might exacerbate Graves’ disease: A multicenter observational case control study2021
- Author(s)
  Sekizaki Tomonori、Kameda Hiraku、Nomoto Hiroshi、Cho Kyu Yong、Nakamura Akinobu、Takahashi Kiyohiko、Miyoshi Arina、Wada Norio、Takeuchi Jun、Nagai So、Miyoshi Hideaki、Atsumi Tatsuya
- Journal Title
  
  Journal of Diabetes Investigation
  
  Volume: 12 Issue: 11 Pages: 1978-1982
- DOI
  10.1111/jdi.13578
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K17481
[Journal Article] Two Distinctive <i>POMC</i> Promoters Modify Gene Expression in Cushing Disease2021
- Author(s)
  Araki Takako、Tone Yukiko、Yamamoto Masaaki、Kameda Hiraku、Ben-Shlomo Anat、Yamada Shozo、Takeshita Akira、Yamamoto Masato、Kawakami Yasuhiko、Tone Masahide、Melmed Shlomo
- Journal Title
  
  The Journal of Clinical Endocrinology & Metabolism
  
  Volume: 106 Issue: 9 Pages: e3346-e3363
- DOI
  10.1210/clinem/dgab387
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08899, KAKENHI-PROJECT-20K08907, KAKENHI-PROJECT-20K17481
[Journal Article] The association between hypoglycemia and glycemic variability in elderly patients with type 2 diabetes: a prospective observational study2021
- Author(s)
  Handa T, Nakamura A, Miya A, Nomoto H, Kameda H, Cho KY, Nagai S, Yoshioka N, Miyoshi H, Atsumi T.
- Journal Title
  
  Diabetol Metab Syndr
  
  Volume: 1 Issue: 1 Pages: 1-8
- DOI
  10.1186/s13098-021-00656-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K17481
[Journal Article] Log-linear relationship between endogenous insulin secretion and glycemic variability in patients with type 2 diabetes on continuous glucose monitoring2021
- Author(s)
  Miya Aika、Nakamura Akinobu、Handa Takahisa、Nomoto Hiroshi、Kameda Hiraku、Cho Kyu Yong、Nagai So、Ito Yoichi M.、Miyoshi Hideaki、Atsumi Tatsuya
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 1-10
- DOI
  10.1038/s41598-021-88749-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K17481
[Journal Article] Silent pituitary adenoma and metabolic disorders: obesity, abnormal glucose tolerance, hypertension and dyslipidemia2021
- Author(s)
  Baba Natsuki、Kameda Hiraku、Nakamura Akinobu、Yong Cho Kyu、Nomoto Hiroshi、Mitsuhashi Tomoko、Miyoshi Hideaki、Atsumi Tatsuya
- Journal Title
  
  Endocr J
  
  Volume: 68 Issue: 2 Pages: 195-200
- DOI
  10.1507/endocrj.EJ20-0185
- NAID
  130007992407
- ISSN
  0918-8959, 1348-4540
- Language
  English
- Data Source
  KAKENHI-PROJECT-20K17481
[Journal Article] Lowering of blood pressure and pulse rate by switching from DPP-4 inhibitor to luseogliflozin in patients with type 2 diabetes complicated with hypertension: A multicenter, prospective, randomized, open-label, parallel-group comparison trial (LUNA study)2021
- Author(s)
  Hashimoto-Kameda Reina、Cho Kyu Yong、Nomoto Hiroshi、Nakamura Akinobu、Omori Kazuno、Nagai So、Edagawa Sachiko、Kawata Shinichiro、Takeuchi Jun、Kameda Hiraku、Kurihara Yoshio、Aoki Shin、Atsumi Tatsuya、Miyoshi Hideaki
- Journal Title
  
  Diabetes Research and Clinical Practice
  
  Volume: 180 Pages: 109069-109069
- DOI
  10.1016/j.diabres.2021.109069
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K17481
[Journal Article] Severe infection including disseminated herpes zoster triggered by subclinical Cushing’s disease: a case report2021
- Author(s)
  Yamauchi Yuki、Kameda Hiraku、Omori Kazuno、Tani Michio、Cho Kyu Yong、Nakamura Akinobu、Miyoshi Hideaki、Tanaka Shinya、Atsumi Tatsuya
- Journal Title
  
  BMC Endocrine Disorders
  
  Volume: 21 Issue: 1 Pages: 1-6
- DOI
  10.1186/s12902-021-00757-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K17481
[Journal Article] Favorable effects of burosumab on tumor-induced osteomalacia caused by an undetectable tumor2021
- Author(s)
  Oe Yuki、Kameda Hiraku、Nomoto Hiroshi、Sakamoto Keita、Soyama Takeshi、Cho Kyu Yong、Nakamura Akinobu、Iwasaki Koji、Abo Daisuke、Kudo Kohsuke、Miyoshi Hideaki、Atsumi Tatsuya
- Journal Title
  
  Medicine
  
  Volume: 100 Issue: 46 Pages: e27895-e27895
- DOI
  10.1097/md.0000000000027895
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K17481
[Journal Article] Glucokinase activation leads to an unsustained hypoglycaemic effect with hepatic triglyceride accumulation in db/db mice2021
- Author(s)
  Kawata Shinichiro、Nakamura Akinobu、Miyoshi Hideaki、Yang Kelaier、Shigesawa Ikumi、Yamauchi Yuki、Tsuchida Kazuhisa、Omori Kazuno、Takahashi Kiyohiko、Nomoto Hiroshi、Kameda Hiraku、Cho Kyu Yong、Terauchi Yasuo、Atsumi Tatsuya
- Journal Title
  
  Diabetes, Obesity and Metabolism
  
  Volume: 24 Issue: 3 Pages: 391-401
- DOI
  10.1111/dom.14586
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08992, KAKENHI-PROJECT-20K17481
[Journal Article] Use of magnetic resonance venography for inferior petrosal sinus sampling2021
- Author(s)
  Tokairin Kikutaro、Osanai Toshiya、Fujima Noriyuki、Ishizaka Kinya、Motegi Hiroaki、Ishi Yukitomo、Kameda Hiraku、Sugiyama Taku、Kazumata Ken、Nakayama Naoki
- Journal Title
  
  The Journal of Vascular Access
  
  Volume: 2021 Feb 24 Issue: 3 Pages: 1-8
- DOI
  10.1177/1129729821997263
- Data Source
  KAKENHI-PROJECT-20K17481
[Journal Article] Acromegaly Cases Exhibiting Increased Growth Hormone Levels during Oral Glucose Loading with Preadministration of Dipeptidyl Peptidase-4 Inhibitor2021
- Author(s)
  Oba-Yamamoto Chiho、Kameda Hiraku、Miyoshi Hideaki、Sekizaki Tomonori、Takase Takahiro、Yanagimachi Tsuyoshi、Fujita Yukihiro、Nomoto Hiroshi、Cho Kyu Yong、Nakamura Akinobu、Nagai So、Atsumi Tatsuya
- Journal Title
  
  Intern. Med.
  
  Volume: 60 Issue: 15 Pages: 2375-2383
- DOI
  10.2169/internalmedicine.4755-20
- NAID
  130008070652
- ISSN
  0918-2918, 1349-7235
- Year and Date
  2021-08-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K17481
[Journal Article] Successful management of a patient with active Cushing’s disease complicated with coronavirus disease 2019 (COVID-19) pneumonia2021
- Author(s)
  Yuno Akiko、Kenmotsu Yoshiyuki、Takahashi Yuka、Nomoto Hiroshi、Kameda Hiraku、Cho Kyu ?Yong、Nakamura Akinobu、Yamashita Yu、Nakamura Junichi、Nakakubo Sho、Kamada Keisuke、Suzuki Masaru、Sugino Hirokazu、Inoshita Naoko、Konno Satoshi、Miyoshi Hideaki、Atsumi Tatsuya、Sawamura Yutaka、Shimatsu Akira
- Journal Title
  
  Endocr J
  
  Volume: 68 Issue: 4 Pages: 477-484
- DOI
  10.1507/endocrj.EJ20-0613
- NAID
  130008030746
- ISSN
  0918-8959, 1348-4540
- Language
  English
- Data Source
  KAKENHI-PROJECT-20K17481
[Journal Article] Impact of sodium glucose cotransporter 2 inhibitors on renal function in participants with type 2 diabetes and chronic kidney disease with normoalbuminuria2020
- Author(s)
  Nakamura Akinobu、Miyoshi Hideaki、Kameda Hiraku、Yamashita Kumiko、Kurihara Yoshio
- Journal Title
  
  Diabetology & Metabolic Syndrome
  
  Volume: 12 Issue: 1
- DOI
  10.1186/s13098-020-0516-9
- Data Source
  KAKENHI-PROJECT-19K21329
[Journal Article] Nivolumab-induced hypophysitis causing secondary adrenal insufficiency after transient ACTH elevation2019
- Author(s)
  Sekizaki Tomonori、Kameda Hiraku、Oba Chiho、Yong Cho Kyu、Nakamura Akinobu、Miyoshi Hideaki、Osawa Takahiro、Shinohara Nobuo、Atsumi Tatsuya
- Journal Title
  
  Endocr J
  
  Volume: 66 Issue: 10 Pages: 937-941
- DOI
  10.1507/endocrj.EJ19-0076
- NAID
  130007734468
- ISSN
  0918-8959, 1348-4540
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K09155, KAKENHI-PROJECT-19K21329
[Journal Article] Protective effect of sodium?glucose cotransporter?2 inhibitors in patients with rapid renal function decline, stage G3 or G4 chronic kidney disease and type?2 diabetes2019
- Author(s)
  Miyoshi Hideaki、Kameda Hiraku、Yamashita Kumiko、Nakamura Akinobu、Kurihara Yoshio
- Journal Title
  
  Journal of Diabetes Investigation
  
  Volume: 10 Issue: 6 Pages: 1510-1517
- DOI
  10.1111/jdi.13064
- Data Source
  KAKENHI-PROJECT-19K21329
[Journal Article] Excess growth hormone suppresses DNA damage repair in epithelial cells2019
- Author(s)
  Chesnokova Vera、Zonis Svetlana、Barrett Robert、Kameda Hiraku、Wawrowsky Kolja、Ben-Shlomo Anat、Yamamoto Masaaki、Gleeson John、Bresee Catherine、Gorbunova Vera、Melmed Shlomo
- Journal Title
  
  JCI Insight
  
  Volume: 4 Issue: 3
- DOI
  10.1172/jci.insight.125762
- Data Source
  KAKENHI-PROJECT-19K21329
[Journal Article] Effects of dapagliflozin and/or insulin glargine on beta cell mass and hepatic steatosis in db/db mice2019
- Author(s)
  Omori Kazuno、Nakamura Akinobu、Miyoshi Hideaki、Takahashi Kiyohiko、Kitao Naoyuki、Nomoto Hiroshi、Kameda Hiraku、Cho Kyu Yong、Takagi Ryo、Hatanaka Kanako C.、Terauchi Yasuo、Atsumi Tatsuya
- Journal Title
  
  Metabolism
  
  Volume: 98 Pages: 27-36
- DOI
  10.1016/j.metabol.2019.06.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08992, KAKENHI-PROJECT-19K21329
[Presentation] Mechanism of adrenal steroid hormone synthesis enhancement in type 2 diabetes mellitus and the effects of DHCR24 inhibitor.2022
- Author(s)
  Kamigaki R, Kameda H, Shibayama Y, Nomoto H, Cho KY, Nakamura A, Jin S, Matoba K, Miyoshi H, Atsumi T.
- Organizer
  The Endocrine Society’s annual meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K17481
[Presentation] A Case of Nephrogenic Diabetes Insipidus Diagnosed at an Advanced Age in a Female Patient with an AVPR2 Gene Mutation and Skewed X Inactivation2022
- Author(s)
  Nakata K, Kameda H, Kuwabara S, Yasui A, Takahashi Y, Miya A, Nomoto H, Cho KY, Nakamura A, Miyoshi H, Okada E, Nozu K, Atsumi T.
- Organizer
  The Endocrine Society’s annual meeting.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K17481
[Presentation] Neuromedin B receptor antagonist suppresses ACTH secretion and cell proliferation in human and mouse corticotroph adenoma2022
- Author(s)
  Sekizaki T, Kameda H, Nakamura A, Miya A, Nomoto H, Cho KY, Motegi H, Miyoshi H, Atsumi T.
- Organizer
  The Endocrine Society’s annual meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K17481
[Presentation] GH産生下垂体腺腫におけるβ-カテニンの細胞内局在と臨床所見との関連2022
- Author(s)
  桑原咲、亀田啓、野本博司、曺圭龍、中村昭伸、伊師雪友、茂木洋晃、藤村幹、渥美達也.
- Organizer
  第48回日本神経内分泌学会学術集会
- Data Source
  KAKENHI-PROJECT-20K17481
[Presentation] 細胞株、マウス、患者由来腺腫細胞を用いた、クッシング病に対するニューロメジンB受容体拮抗薬の増殖・ホルモン分泌抑制効果の検討2022
- Author(s)
  関崎知紀、亀田啓、宮愛香、野本博司、曺圭龍、茂木洋晃、中村昭伸、三好秀明、渥美達也．
- Organizer
  日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K17481
[Presentation] Neuromedin B receptor antagonist suppress Pomc expression and cell proliferation in AtT-20 cells2019
- Author(s)
  亀田　啓
- Organizer
  16th Pituitary Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K21329
[Presentation] クッシング病への挑戦：基礎研究から臨床応用へ　講演1：HPA axis調節因子とその異常クッシング病への挑戦：基礎研究から臨床応用へ講演1：HPA axis調節因子とその異常2019
- Author(s)
  亀田　啓
- Organizer
  第92回日本内分泌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-19K21329
[Presentation] クッシング病の新規治療薬の探索2019
- Author(s)
  亀田　啓, 関崎　知紀, 曺　圭龍, 中村　昭伸, 三好　秀明, 渥美　達也
- Organizer
  第56回日本臨床分子医学会
- Data Source
  KAKENHI-PROJECT-19K21329

1. 神繁樹 (60531845)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 的場光太郎 (00466450)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 木内隆之 (80990085)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. NAKAMURA Akinobu

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
5. 竹下章

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 山田正三

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 藤沢治樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 山本雅昭

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kameda Hiraku 亀田 啓

Research Projects

Research Products

Co-Researchers

ステロイド生合成プロファイル解析による新たな低温症診断への可能性

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Neuromedin B receptor antagonists as a novel treatment for Cushing's disease.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Neuromedin B receptor antagonist as a new treatment for Cushing diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] The Impact of Multicultural Interfacility Video Case Conference: A Novel Education Model After the COVID Pandemic.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] False Hypercortisolemia Due to Abnormal Albumin-Cortisol Binding in a Patient with Familial Dysalbuminemic Hyperthyroxinemia2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Lymphocytic panhypophysitis and anti-rabphilin-3A antibody with pulmonary sarcoidosis2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dipeptidyl peptidase‐4 inhibitor might exacerbate Graves’ disease: A multicenter observational case control study2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Two Distinctive <i>POMC</i> Promoters Modify Gene Expression in Cushing Disease2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The association between hypoglycemia and glycemic variability in elderly patients with type 2 diabetes: a prospective observational study2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Log-linear relationship between endogenous insulin secretion and glycemic variability in patients with type 2 diabetes on continuous glucose monitoring2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Silent pituitary adenoma and metabolic disorders: obesity, abnormal glucose tolerance, hypertension and dyslipidemia2021

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Lowering of blood pressure and pulse rate by switching from DPP-4 inhibitor to luseogliflozin in patients with type 2 diabetes complicated with hypertension: A multicenter, prospective, randomized, open-label, parallel-group comparison trial (LUNA study)2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Severe infection including disseminated herpes zoster triggered by subclinical Cushing’s disease: a case report2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Favorable effects of burosumab on tumor-induced osteomalacia caused by an undetectable tumor2021

Author(s)

Journal Title

DOI

Data Source

Kameda Hiraku 亀田啓