Hiraoka Takehiro 平岡毅大

Researcher Number	20836762
Other IDs
Affiliation (Current)	2025: 大阪大学, 免疫学フロンティア研究センター, 特任助教(常勤)
Affiliation (based on the past Project Information) *help	2023: 大阪大学, 微生物病研究所, 特任研究員(常勤) 2022: 東京大学, 医学部附属病院, 特別研究員 2021: 東京大学, 医学部附属病院, 助教 2019 – 2020: 北里大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 56040:Obstetrics and gynecology-related / Basic Section 42040:Laboratory animal science-related Except Principal Investigator Basic Section 42040:Laboratory animal science-related
Keywords	Principal Investigator 着床 / 組織培養 / 子宮内膜 / 胚発生 / 脱細胞化組織 / 着床障害 / 再生医療 / 子宮性不妊症 / 子宮再生医療 / 子宮腺筋症 / STAT3 … More Except Principal Investigator … More 胚浸潤 / 着床不全 / 不妊症 / 子宮内膜 / マウスモデル / 妊娠 / 着床 Less

胚－子宮内膜共培養系の確立とその解析による着床および着床後胚発生機序の解明Principal Investigator
- Principal Investigator
  
  平岡毅大
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Osaka University
Mechanism of blastocyst invasion controlled by uterine factors
- Principal Investigator
  
  廣田泰
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42040:Laboratory animal science-related
- Research Institution
  The University of Tokyo
Establishment of uterine bioengineering technology for reproductive medicinePrincipal Investigator
- Principal Investigator
  
  Hiraoka Takehiro
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 42040:Laboratory animal science-related
- Research Institution
  The University of Tokyo
  Kitasato University

All 2023 2022 2021 2020 2019

All Journal Article Presentation

[Journal Article] The EZH2?PRC2?H3K27me3 axis governs the endometrial cell cycle and differentiation for blastocyst invasion2023
- Author(s)
  Fukui Yamato、Hirota Yasushi、Aikawa Shizu、Sakashita Akihiko、Shimizu-Hirota Ryoko、Takeda Norihiko、Ishizawa Chihiro、Iida Rei、Kaku Tetsuaki、Hirata Tomoyuki、Hiraoka Takehiro、Akaeda Shun、Matsuo Mitsunori、Osuga Yutaka
- Journal Title
  
  Cell Death & Disease
  
  Volume: 14 Issue: 5 Pages: 320-320
- DOI
  10.1038/s41419-023-05832-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K15814, KAKENHI-PROJECT-23K15827, KAKENHI-PROJECT-22K19596, KAKENHI-PUBLICLY-22H04700, KAKENHI-PROJECT-23K23803
[Journal Article] Pregnancy is associated with reduced progression of symptomatic adenomyosis: a retrospective pilot study2023
- Author(s)
  Hiratsuka Daiki、Omura Erika、Ishizawa Chihiro、Iida Rei、Fukui Yamato、Hiraoka Takehiro、Akaeda Shun、Matsuo Mitsunori、Harada Miyuki、Wada-Hiraike Osamu、Osuga Yutaka、Hirota Yasushi
- Journal Title
  
  BMC Pregnancy and Childbirth
  
  Volume: 23 Issue: 1 Pages: 634-634
- DOI
  10.1186/s12884-023-05956-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K15814, KAKENHI-PROJECT-21K09489
[Journal Article] Current perspectives on endometrial receptivity: A comprehensive overview of etiology and treatment2023
- Author(s)
  Hiraoka Takehiro、Osuga Yutaka、Hirota Yasushi
- Journal Title
  
  Journal of Obstetrics and Gynaecology Research
  
  Volume: 49 Issue: 10 Pages: 2397-2409
- DOI
  10.1111/jog.15759
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K15814, KAKENHI-PROJECT-22K19596
[Journal Article] Constant Activation of STAT3 Contributes to the Development of Adenomyosis in Females2022
- Author(s)
  Hiraoka Takehiro、Hirota Yasushi、Aikawa Shizu、Iida Rei、Ishizawa Chihiro、Kaku Tetsuaki、Hirata Tomoyuki、Fukui Yamato、Akaeda Shun、Matsuo Mitsunori、Shimizu-Hirota Ryoko、Takeda Norihiko、Osuga Yutaka
- Journal Title
  
  Endocrinology
  
  Volume: 163 Issue: 5
- DOI
  10.1210/endocr/bqac044
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16022, KAKENHI-PROJECT-16H06279, KAKENHI-PROJECT-22K19595, KAKENHI-PROJECT-22K16852, KAKENHI-PROJECT-19H03144, KAKENHI-PROJECT-22K19596, KAKENHI-PROJECT-19H03796
[Journal Article] DNA Methylation and Histone Modification Are the Possible Regulators of Preimplantation Blastocyst Activation in Mice2022
- Author(s)
  Hiratsuka Daiki、Aikawa Shizu、Hirota Yasushi、Fukui Yamato、Akaeda Shun、Hiraoka Takehiro、Matsuo Mitsunori、Osuga Yutaka
- Journal Title
  
  Reproductive Sciences
  
  Volume: 30 Issue: 2 Pages: 494-525
- DOI
  10.1007/s43032-022-00988-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K19595, KAKENHI-PROJECT-22H04925, KAKENHI-PROJECT-23K23803
[Journal Article] A gene network of uterine luminal epithelium organizes mouse blastocyst implantation2022
- Author(s)
  Aikawa Shizu、Hirota Yasushi、Fukui Yamato、Ishizawa Chihiro、IIda Rei、Kaku Tetsuaki、Hirata Tomoyuki、Akaeda Shun、Hiraoka Takehiro、Matsuo Mitsunori、Osuga Yutaka
- Journal Title
  
  Reproductive Medicine and Biology
  
  Volume: 21 Issue: 1
- DOI
  10.1002/rmb2.12435
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16022, KAKENHI-PROJECT-20J11585, KAKENHI-PROJECT-21J00509, KAKENHI-PROJECT-22K19595, KAKENHI-PROJECT-22K16852, KAKENHI-PROJECT-22H04925, KAKENHI-PROJECT-19H03144, KAKENHI-PROJECT-19H03796, KAKENHI-PROJECT-23K23803
[Journal Article] Uterine Epithelial LIF Receptors Contribute to Implantation Chamber Formation in Blastocyst Attachment2021
- Author(s)
  Fukui Yamato、Hirota Yasushi、Saito-Fujita Tomoko、Aikawa Shizu、Hiraoka Takehiro、Kaku Tetsuaki、Hirata Tomoyuki、Akaeda Shun、Matsuo Mitsunori、Shimizu-Hirota Ryoko、Takeda Norihiko、Ikawa Masahito、Osuga Yutaka
- Journal Title
  
  Endocrinology
  
  Volume: 162 Issue: 11
- DOI
  10.1210/endocr/bqab169
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16022, KAKENHI-PROJECT-20J11585, KAKENHI-PROJECT-21J00509, KAKENHI-PROJECT-19H03144, KAKENHI-PROJECT-19H03796
[Journal Article] Uterine Receptivity is Reflected by LIF Expression in the Cervix2021
- Author(s)
  Fukui Yamato、Hirota Yasushi、Aikawa Shizu、Ishizawa Chihiro、Iida Rei、Kaku Tetsuaki、Hirata Tomoyuki、Akaeda Shun、Hiraoka Takehiro、Matsuo Mitsunori、Osuga Yutaka
- Journal Title
  
  Reproductive Sciences
  
  Volume: 29 Issue: 5 Pages: 1457-1462
- DOI
  10.1007/s43032-021-00816-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16022, KAKENHI-PROJECT-20J11585, KAKENHI-PROJECT-21J00509, KAKENHI-PROJECT-22K19595, KAKENHI-PROJECT-22K16852, KAKENHI-PROJECT-19H03144, KAKENHI-PROJECT-19H03796, KAKENHI-PROJECT-23K23803
[Journal Article] CD206+?macrophage is an accelerator of endometriotic-like lesion via promoting angiogenesis in the endometriosis mouse model2021
- Author(s)
  Ono Yosuke、Yoshino Osamu、Hiraoka Takehiro、Sato Erina、Furue Akiko、Nawaz Allah、Hatta Hideki、Fukushi Yoshiyuki、Wada Shinichiro、Tobe Kazuyuki、Hirota Yasushi、Osuga Yutaka、Unno Nobuya、Saito Shigeru
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 853-853
- DOI
  10.1038/s41598-020-79578-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16022, KAKENHI-PROJECT-20K22733, KAKENHI-PROJECT-19H03796, KAKENHI-PROJECT-19H03144, KAKENHI-PROJECT-19K09823
[Journal Article] Retinoblastoma protein promotes uterine epithelial cell cycle arrest and necroptosis for embryo invasion2021
- Author(s)
  Akaeda Shun、Hirota Yasushi、Fukui Yamato、Aikawa Shizu、Shimizu‐Hirota Ryoko、Kaku Tetsuaki、Gebril Mona、Hirata Tomoyuki、Hiraoka Takehiro、Matsuo Mitsunori、Haraguchi Hirofumi、Saito‐Kanatani Mayuko、Takeda Norihiko、Fujii Tomoyuki、Osuga Yutaka
- Journal Title
  
  EMBO reports
  
  Volume: 22 Issue: 2
- DOI
  10.15252/embr.202050927
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16022, KAKENHI-PROJECT-19H03796, KAKENHI-PROJECT-20J11585, KAKENHI-PROJECT-19K18630, KAKENHI-PROJECT-19K18631, KAKENHI-PROJECT-20K22732, KAKENHI-PROJECT-19H03144
[Journal Article] IL-33 Exacerbates Endometriotic Lesions via Polarizing Peritoneal Macrophages to M2 Subtype.2020
- Author(s)
  Ono Yosuke, Yoshino Osamu, Takehiro Hiraoka, Akiyama Ikumi, Sato Erina, Ito Masami, Kobayashi Matsumi, Nakashima Akitoshi, Wada Shinichiro, Onda Takashi, Unno Nobuya, Osuga Yutaka
- Journal Title
  
  Endocrinology
  
  Volume: 27 Issue: 3 Pages: 869-876
- DOI
  10.1007/s43032-019-00090-9
- Data Source
  KAKENHI-PROJECT-19K16022
[Journal Article] Differential roles of uterine epithelial and stromal STAT3 coordinate uterine receptivity and embryo attachment2020
- Author(s)
  Hiraoka Takehiro、Hirota Yasushi、Fukui Yamato、Gebril Mona、Kaku Tetsuaki、Aikawa Shizu、Hirata Tomoyuki、Akaeda Shun、Matsuo Mitsunori、Haraguchi Hirofumi、Saito-Kanatani Mayuko、Shimizu-Hirota Ryoko、Takeda Norihiko、Yoshino Osamu、Fujii Tomoyuki、Osuga Yutaka
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 15523-15523
- DOI
  10.1038/s41598-020-72640-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09823, KAKENHI-PROJECT-19K16022, KAKENHI-PROJECT-19H03796, KAKENHI-PROJECT-20J11585, KAKENHI-PROJECT-19K18630, KAKENHI-PROJECT-19K18631, KAKENHI-PROJECT-20K22732, KAKENHI-PROJECT-19H03144
[Journal Article] Levonorgestrel Inhibits Embryo Attachment by Eliminating Uterine Induction of Leukemia Inhibitory Factor2019
- Author(s)
  Matsuo Mitsunori、Hirota Yasushi、Fukui Yamato、Fujita Hidetoshi、Saito-Fujita Tomoko、Kaku Tetsuaki、Gebril Mona、Hirata Tomoyuki、Akaeda Shun、Hiraoka Takehiro、Tanaka Tomoki、Haraguchi Hirofumi、Saito-Kanatani Mayuko、Shimizu-Hirota Ryoko、Takeda Norihiko、Fujii Tomoyuki、Osuga Yutaka
- Journal Title
  
  Endocrinology
  
  Volume: 161 Issue: 2
- DOI
  10.1210/endocr/bqz005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16022, KAKENHI-PROJECT-19K18631, KAKENHI-PROJECT-18K19601, KAKENHI-PROJECT-19H03796, KAKENHI-PROJECT-19K18630
[Journal Article] Uterine receptivity, embryo attachment, and embryo invasion: Multistep processes in embryo implantation2019
- Author(s)
  Fukui Yamato、Hirota Yasushi、Matsuo Mitsunori、Gebril Mona、Akaeda Shun、Hiraoka Takehiro、Osuga Yutaka
- Journal Title
  
  Reproductive Medicine and Biology
  
  Volume: 18 Issue: 3 Pages: 234-240
- DOI
  10.1002/rmb2.12280
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16022, KAKENHI-PROJECT-19H03796, KAKENHI-PROJECT-18K19601, KAKENHI-PROJECT-16H04679, KAKENHI-PROJECT-16H05469, KAKENHI-PROJECT-19H03144
[Presentation] Insights into the pathophysiology of adenomyosis by developing a new mouse model with mechanical trauma.2023
- Author(s)
  Takehiro Hiraoka, Yasushi Hirota, Yutaka Osuga
- Organizer
  FIGO World Congress 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K15814
[Presentation] A new mouse model of mechanically induced adenomyosis2023
- Author(s)
  Takehiro Hiraoka, Yasushi Hirota, Yutaka Osuga
- Organizer
  Royal College of Obstetricians and Gynaecologists 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K15814
[Presentation] 反復着床不全子宮腺筋症合併不妊に対する治療指針の探求2022
- Author(s)
  松尾光徳, 廣田泰, 藍川志津, 石沢千尋, 飯田麗, 平田知之, 賀来哲明, 福井大和, 赤枝俊, 平岡毅大, 大須賀穣
- Organizer
  第67回日本生殖医学会学術講演会
- Invited
- Data Source
  KAKENHI-PROJECT-23K23803
[Presentation] マウス子宮腺筋症モデルを用いた子宮腺筋症発生における転写因子STAT3の機能解析2021
- Author(s)
  平岡毅大、廣田泰、福井大和、賀来哲明、平田知之、岩瀬春子, 吉野修、海野信也、藤井知行、大須賀穣
- Organizer
  第42回日本エンドメトリオーシス学会学術講演会
- Data Source
  KAKENHI-PROJECT-19K16022
[Presentation] Distinct functions of uterine epithelial and stromal STAT3 orchestrate uterine receptivity and embryo attachment2021
- Author(s)
  Hiraoka T, Hirota Y, Fukui Y, Kaku T, Hirata T, Akaeda S, Matsuo M, Iwase H, Yoshino O, Unno N, Fuii T, Osuga Y
- Organizer
  The 73rd Annual Congress of the Japan Society of Obstetrics and Gynecology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16022
[Presentation] Distinct functions of uterine epithelial and stromal STAT3 orchestrate uterine receptivity and embryo attachment2021
- Author(s)
  Takehiro Hiraoka, Yasushi Hirota, Yamato Fukui, Tetsuaki Kaku, Tomoyuki Hirata, Shun Akaeda, Mitsunori Matsuo, Haruko Iwase, Osamu Yoshino, Nobuya Unno, Tomoyuki Fujii, Yutaka Osuga
- Organizer
  The 73th Annual Congress of the Japan Society of Obstetrics and Gynecology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16022
[Presentation] 卵巣子宮内膜症性嚢胞の癌化における卵巣ホルモン受容体の機能的意義に関する検討2020
- Author(s)
  平岡毅大、吉野修、松本俊英、三枝信、岩端俊輔、伊藤実香、本田雅子、岩瀬春子、時任泉湖、恩田貴志
- Organizer
  第41回日本エンドメトリオーシス学会学術講演会
- Data Source
  KAKENHI-PROJECT-19K16022
[Presentation] 子宮鏡手術前にGnRHアンタゴニスト(レルミナ)を投与した6症例2019
- Author(s)
  伊藤実香、平岡毅大、岩端俊輔、本田雅子、吉野修、恩田貴志
- Organizer
  第427回神奈川産科婦人科学会
- Data Source
  KAKENHI-PROJECT-19K16022
[Presentation] 経筋層的胚移植についての再考2019
- Author(s)
  岩端俊輔、平岡毅大、伊藤実香、本田雅子、吉野修、恩田貴志
- Organizer
  第64回日本生殖医学会学術講演会
- Data Source
  KAKENHI-PROJECT-19K16022

1. 廣田泰 (40598653)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
2. 藍川志津 (80884577)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
3. 赤枝俊 (10898084)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
4. 清水良子 (30348643)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 吉野修

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hiraoka Takehiro 平岡 毅大

Research Projects

Research Products

Co-Researchers

胚－子宮内膜共培養系の確立とその解析による着床および着床後胚発生機序の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanism of blastocyst invasion controlled by uterine factors

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of uterine bioengineering technology for reproductive medicinePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] The EZH2?PRC2?H3K27me3 axis governs the endometrial cell cycle and differentiation for blastocyst invasion2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Pregnancy is associated with reduced progression of symptomatic adenomyosis: a retrospective pilot study2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Current perspectives on endometrial receptivity: A comprehensive overview of etiology and treatment2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Constant Activation of STAT3 Contributes to the Development of Adenomyosis in Females2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] DNA Methylation and Histone Modification Are the Possible Regulators of Preimplantation Blastocyst Activation in Mice2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A gene network of uterine luminal epithelium organizes mouse blastocyst implantation2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Uterine Epithelial LIF Receptors Contribute to Implantation Chamber Formation in Blastocyst Attachment2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Uterine Receptivity is Reflected by LIF Expression in the Cervix2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CD206+?macrophage is an accelerator of endometriotic-like lesion via promoting angiogenesis in the endometriosis mouse model2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Retinoblastoma protein promotes uterine epithelial cell cycle arrest and necroptosis for embryo invasion2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] IL-33 Exacerbates Endometriotic Lesions via Polarizing Peritoneal Macrophages to M2 Subtype.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Differential roles of uterine epithelial and stromal STAT3 coordinate uterine receptivity and embryo attachment2020

Author(s)

Journal Title

Hiraoka Takehiro 平岡毅大

[Presentation] 反復着床不全子宮腺筋症合併不妊に対する治療指針の探求2022