Yamauchi Ichiro 山内一郎

Researcher Number	20844715
Other IDs
Affiliation (Current)	2026: 京都大学, 医学研究科, 助教
Affiliation (based on the past Project Information) *help	2019 – 2024: 京都大学, 医学研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 54040:Metabolism and endocrinology-related / 0902:General internal medicine and related fields
Keywords	Principal Investigator トランスクリプトーム / バセドウ病 / トランスクリプトーム解析 / TSH / モデルマウス / 甲状腺機能亢進症 / トランスポーター / ヨード / RNA-seq / ペンドリン … More / 甲状腺刺激ホルモン / 抗甲状腺薬 / チアマゾール / 内分泌障害 / 免疫関連有害事象 / ニボルマブ / irAE / 自己抗体 / 下垂体 / 甲状腺 / PD-1 / 免疫チェックポイント阻害薬 Less

Is the Iodide Transporter Pendrin a Possible Therapeutic Target for Hyperthyroidism?Principal Investigator
- Principal Investigator
  
  Yamauchi Ichiro
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Kyoto University
Exploring therapeutic targets for hyperthyroidism using TSH-overexpressing mousePrincipal Investigator
- Principal Investigator
  
  Yamauchi Ichiro
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Kyoto University
Endocrine-related adverse events induced by immune checkpoint inhibitors: from clinical features to mechanistic insightsPrincipal Investigator
- Principal Investigator
  
  Yamauchi Ichiro
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0902:General internal medicine and related fields
- Research Institution
  Kyoto University

All 2025 2024 2023 2022 2021 2020 2019

All Journal Article Presentation

[Journal Article] Transcriptomic landscape of hyperthyroidism in mice overexpressing thyroid-stimulating hormone2025
- Author(s)
  Yamauchi Ichiro、Sugawa Taku、Hakata Takuro、Yoshizawa Akira、Kita Tomoko、Kishimoto Yo、Kimura Sadahito、Sakurai Aya、Kosugi Daisuke、Fujita Haruka、Okamoto Kentaro、Ueda Yohei、Fujii Toshihito、Taura Daisuke、Sakane Yoriko、Yasoda Akihiro、Inagaki Nobuya
- Journal Title
  
  iScience
  
  Volume: 28 Issue: 1 Pages: 111565-111565
- DOI
  10.1016/j.isci.2024.111565
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K09705, KAKENHI-PROJECT-22K16394, KAKENHI-PROJECT-24K09957, KAKENHI-PROJECT-24K11712, KAKENHI-PROJECT-23K15410
[Journal Article] TRIAC disrupts cerebral thyroid hormone action via negative feedback and heterogenous distribution among organs2023
- Author(s)
  Yamauchi Ichiro、Hakata Takuro、Ueda Yohei、Sugawa Taku、Omagari Ryo、Teramoto Yasuo、Nakayama Shoji F.、Nakajima Daisuke、Kubo Takuya、Inagaki Nobuya
- Journal Title
  
  iScience
  
  Volume: 26 Issue: 7 Pages: 107135-107135
- DOI
  10.1016/j.isci.2023.107135
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K16394
[Journal Article] High-throughput Screening in Combination With a Cohort Study for Iodothyronine Deiodinases2022
- Author(s)
  Yamauchi Ichiro、Sakane Yoriko、Okuno Yukiko、Sugawa Taku、Hakata Takuro、Fujita Haruka、Okamoto Kentaro、Taura Daisuke、Yamashita Takafumi、Hirota Keisho、Ueda Yohei、Fujii Toshihito、Yasoda Akihiro、Inagaki Nobuya
- Journal Title
  
  Endocrinology
  
  Volume: 163 Issue: 8 Pages: 1-17
- DOI
  10.1210/endocr/bqac090
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K16394, KAKENHI-PROJECT-20K08877
[Journal Article] Identification by Liquid Chromatography?Tandem Mass Spectrometry and Liquid Chromatography?Quadrupole Time-of-Flight Mass Spectrometry of the Contributor to the Thyroid Hormone Receptor Agonist Activity in Effluents from Sewage Treatment Plants2022
- Author(s)
  Omagari Ryo、Yagishita Mayuko、Shiraishi Fujio、Nakayama Shoji F.、Terasaki Masanori、Tanigawa Tetsuya、Yamauchi Ichiro、Kubo Takuya、Nakajima Daisuke
- Journal Title
  
  Environmental Science & Technology
  
  Volume: 56 Issue: 19 Pages: 13709-13718
- DOI
  10.1021/acs.est.2c02648
- Data Source
  KAKENHI-PROJECT-22K16394
[Journal Article] Clinical features and thyroid dysfunction in adverse events involving the pituitary gland during PD‐1 blockade therapy2021
- Author(s)
  Yamauchi Ichiro, Taura Daisuke, Hakata Takuro, Fujita Haruka, Okamoto Kentaro, Ueda Yohei, Fujii Toshihito, Inagaki Nobuya
- Journal Title
  
  Clinical Endocrinology
  
  Volume: 94 Issue: 2 Pages: 258-268
- DOI
  10.1111/cen.14349
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K23942
[Journal Article] Novel Thyroid-Specific Autoantibodies in Patients with Immune-Related Adverse Events Involving the Thyroid Gland2021
- Author(s)
  Yamauchi Ichiro, Yasoda Akihiro, Hakata Takuro, Yamashita Takafumi, Hirota Keisho, Ueda Yohei, Fujii Toshihito, Taura Daisuke, Sone Masakatsu, Inagaki Nobuya
- Journal Title
  
  bioRxiv
  
  Volume: －
- DOI
  10.1101/2021.01.14.426670
- Open Access
- Data Source
  KAKENHI-PROJECT-19K23942
[Presentation] Transcriptome analysis of a novel hyperthyroid mouse induced by TSH overexpression2025
- Author(s)
  Sugawa T, Yamauchi I, Hakata T, Yoshizawa A, Kita T, Kishimoto Y, Kimura S, Kosugi D, Fujita H, Okamoto K, Ueda Y, Fujii T, Taura D, Sakane Y, Yasoda A, Inagaki N
- Organizer
  93rd Annual Meeting of the American Thyroid Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K16394
[Presentation] 甲状腺機能亢進症と低下症の深層に迫る2024
- Author(s)
  山内一郎
- Organizer
  第67回日本甲状腺学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-22K16394
[Presentation] バセドウ病に対する薬物療法の開発状況2024
- Author(s)
  山内一郎
- Organizer
  第33回臨床内分泌代謝Update
- Invited
- Data Source
  KAKENHI-PROJECT-22K16394
[Presentation] 甲状腺機能低下マウスを用いたホルモン作用評価系の構築2024
- Author(s)
  55.木村貞仁、山内一郎、須川琢、小杉大輔、伯田琢郎、岡本健太郎、植田洋平、田浦大輔、矢部大介
- Organizer
  第67回日本甲状腺学会学術集会
- Data Source
  KAKENHI-PROJECT-22K16394
[Presentation] TSH過剰発現による新規甲状腺機能亢進症マウスモデルのフェノタイプ解析2024
- Author(s)
  山内一郎、須川琢、伯田琢郎、吉澤亮、喜多知子、岸本曜、木村貞仁、小杉大輔、藤田晴香、岡本健太郎、植田洋平、藤井寿人、田浦大輔、坂根依利子、八十田明宏、稲垣暢也
- Organizer
  第67回日本甲状腺学会学術集会
- Data Source
  KAKENHI-PROJECT-22K16394
[Presentation] Endocrine-Disrupting Potential of 3,3',5-Triiodothyroacetic Acid via Cooperation of Negative Feedback and Heterogenous Distribution2024
- Author(s)
  Yamauchi I, Hakata T, Ueda Y, Sugawa T, Omagari R, TeramotoY, Nakayama SF, Nakajima D, Kubo T, Inagaki N
- Organizer
  21st International Congress of Endocrinology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K16394
[Presentation] 甲状腺濾胞上皮細胞レポーターマウスの開発と選択的回収法の確立2024
- Author(s)
  須川琢、山内一郎、木村貞仁、小杉大輔、伯田琢郎、岡本健太郎、植田洋平、田浦大輔、矢部大介
- Organizer
  第67回日本甲状腺学会学術集会
- Data Source
  KAKENHI-PROJECT-22K16394
[Presentation] Endocrine-disrupting potential of 3,3',5-triiodothyroacetic acid (TRIAC)2023
- Author(s)
  Yamauchi I
- Organizer
  第66回日本甲状腺学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-22K16394
[Presentation] 甲状腺学におけるトランスレーショナルリサーチの実践新規治療開発に向けたTSH受容体シグナルの分子機構解明2023
- Author(s)
  山内　一郎
- Organizer
  第66回日本甲状腺学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-22K16394
[Presentation] 既知化合物スクリーニングを基盤とした甲状腺ホルモン脱ヨード酵素の制御機構解明2023
- Author(s)
  山内　一郎
- Organizer
  第96回日本内分泌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-22K16394
[Presentation] 甲状腺ホルモン脱ヨード酵素のトランスレーショナルリサーチ2023
- Author(s)
  山内　一郎
- Organizer
  第96回日本内分泌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-22K16394
[Presentation] 新規治療開発に向けたTSH受容体シグナルの分子機構解明2023
- Author(s)
  山内　一郎
- Organizer
  第66回日本甲状腺学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-22K16394
[Presentation] 脱ヨード酵素と甲状腺機能 20222022
- Author(s)
  山内一郎
- Organizer
  第65回日本甲状腺学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-22K16394
[Presentation] Effects of peripheral iodothyronine deiodinases on thyroid hormone economy: Insights from the overexpressing mice.2022
- Author(s)
  Yamauchi I, Sakane Y, Yamashita T, Hakata T, Sugawa T, Fujita H, Okamoto K, Taura D, Hirota K, Ueda Y, Fujii T, Yasoda A, Inagaki N
- Organizer
  104th ENDO Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K16394
[Presentation] 新規過剰発現マウスを用いた脱ヨード酵素による甲状腺ホルモン作用調節機構の解析2022
- Author(s)
  山内一郎、坂根依利子、山下貴史、伯田琢郎、須川琢、藤田晴香、岡本健太郎、田浦大輔、植田洋平、藤井寿人、八十田明宏、稲垣暢也
- Organizer
  第95回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-22K16394
[Presentation] 新規治療開発に向けたTSH受容体シグナルの分子機構解明2022
- Author(s)
  山内一郎
- Organizer
  第65回日本甲状腺学会学術集会
- Data Source
  KAKENHI-PROJECT-22K16394
[Presentation] 全エクソーム解析を行った中毒性多結節性甲状腺腫の1例2021
- Author(s)
  山内　一郎、伯田　琢郎、藤田　晴香、岡本　健太郎、植田　洋平、藤井　寿人、田浦　大輔、稲垣　暢也
- Organizer
  第64回日本甲状腺学会学術集会
- Data Source
  KAKENHI-PROJECT-20K17508
[Presentation] 機能獲得型TSHR遺伝子変異を有する中毒性多結節性甲状腺腫の1例2021
- Author(s)
  山内　一郎、伯田　琢郎、藤田　晴香、岡本　健太郎、植田　洋平、藤井　寿人、田浦　大輔、稲垣　暢也
- Organizer
  第94回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K17508
[Presentation] Ipilimumab/Nivolumab併用療法による下垂体関連有害事象の検討2020
- Author(s)
  藤田晴香、山内一郎、伯田琢郎、岡本健太郎、植田洋平、藤井寿人、田浦大輔、稲垣暢也
- Organizer
  第30回臨床内分泌代謝Update
- Data Source
  KAKENHI-PROJECT-19K23942
[Presentation] 抗PD-1抗体による下垂体関連有害事象は甲状腺機能異常を合併する2020
- Author(s)
  山内一郎、田浦大輔、伯田琢郎、藤田晴香、岡本健太郎、植田洋平、藤井寿人、稲垣暢也
- Organizer
  第63回日本甲状腺学会学術集会
- Data Source
  KAKENHI-PROJECT-19K23942
[Presentation] TSH過剰発現マウスの作成と甲状腺機能に関する検討2020
- Author(s)
  山内　一郎
- Organizer
  第63回日本甲状腺学会学術集会
- Data Source
  KAKENHI-PROJECT-20K17508
[Presentation] Novel Autoantibodies for Thyroid-Specific Transcriptional Factors in Patients with Immune-Related Adverse Events Involving the Thyroid Gland2020
- Author(s)
  1.Yamauchi I, Yasoda A, Yamashita T, Ueda Y, Fujii T, Taura D, Sone M, Inagaki N.
- Organizer
  102nd ENDO Annual Meeting 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K23942
[Presentation] 抗PD-1抗体による甲状腺機能異常の発症機序：新規自己抗体の意義2020
- Author(s)
  山内一郎、八十田明宏、山下貴史、植田洋平、藤井寿人、田浦大輔、曽根正勝、稲垣暢也
- Organizer
  第93回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K23942
[Presentation] 抗PD-1抗体による甲状腺機能異常：生命予後との関連を中心に2019
- Author(s)
  山内一郎, 八十田明宏, 藤井寿人, 田浦大輔, 曽根正勝, 稲垣暢也
- Organizer
  第28回臨床内分泌代謝Update
- Data Source
  KAKENHI-PROJECT-19K23942
[Presentation] 甲状腺、下垂体、膵にニボルマブの免疫関連有害事象を生じた1例2019
- Author(s)
  4.岡本健太郎, 山内一郎, 八十田明宏, 植木絢子, 小倉雅仁, 藤井寿人, 田浦大輔, 曽根正勝, 稲垣暢也
- Organizer
  第28回臨床内分泌代謝Update
- Data Source
  KAKENHI-PROJECT-19K23942
[Presentation] イピリムマブ・ニボルマブ併用中に発症した続発性副腎不全の一例2019
- Author(s)
  57.藤田晴香, 山内一郎, 田浦大輔, 臼井亮太, 藤井寿人, 曽根正勝, 稲垣暢也
- Organizer
  第28回臨床内分泌代謝Update
- Data Source
  KAKENHI-PROJECT-19K23942
[Presentation] 抗PD-1抗体による甲状腺機能異常の発症リスクと生命予後との関連2019
- Author(s)
  山内一郎，八十田明宏，藤井寿人，田浦大輔，曽根正勝，稲垣暢也
- Organizer
  第62回日本甲状腺学会学術集会
- Data Source
  KAKENHI-PROJECT-19K23942

1. 喜多知子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 岸本曜

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yamauchi Ichiro 山内 一郎

Research Projects

Research Products

Co-Researchers

Is the Iodide Transporter Pendrin a Possible Therapeutic Target for Hyperthyroidism?Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Exploring therapeutic targets for hyperthyroidism using TSH-overexpressing mousePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Endocrine-related adverse events induced by immune checkpoint inhibitors: from clinical features to mechanistic insightsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Transcriptomic landscape of hyperthyroidism in mice overexpressing thyroid-stimulating hormone2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] TRIAC disrupts cerebral thyroid hormone action via negative feedback and heterogenous distribution among organs2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] High-throughput Screening in Combination With a Cohort Study for Iodothyronine Deiodinases2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification by Liquid Chromatography?Tandem Mass Spectrometry and Liquid Chromatography?Quadrupole Time-of-Flight Mass Spectrometry of the Contributor to the Thyroid Hormone Receptor Agonist Activity in Effluents from Sewage Treatment Plants2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Clinical features and thyroid dysfunction in adverse events involving the pituitary gland during PD‐1 blockade therapy2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Novel Thyroid-Specific Autoantibodies in Patients with Immune-Related Adverse Events Involving the Thyroid Gland2021

Author(s)

Journal Title

DOI

Data Source

[Presentation] Transcriptome analysis of a novel hyperthyroid mouse induced by TSH overexpression2025

Author(s)

Organizer

Data Source

[Presentation] 甲状腺機能亢進症と低下症の深層に迫る2024

Author(s)

Organizer

Data Source

[Presentation] バセドウ病に対する薬物療法の開発状況2024

Author(s)

Organizer

Data Source

[Presentation] 甲状腺機能低下マウスを用いたホルモン作用評価系の構築2024

Author(s)

Organizer

Data Source

[Presentation] TSH過剰発現による新規甲状腺機能亢進症マウスモデルのフェノタイプ解析2024

Author(s)

Organizer

Data Source

[Presentation] Endocrine-Disrupting Potential of 3,3',5-Triiodothyroacetic Acid via Cooperation of Negative Feedback and Heterogenous Distribution2024

Author(s)

Organizer

Data Source

[Presentation] 甲状腺濾胞上皮細胞レポーターマウスの開発と選択的回収法の確立2024

Author(s)

Organizer

Data Source

Yamauchi Ichiro 山内一郎

[Presentation] 甲状腺学におけるトランスレーショナルリサーチの実践新規治療開発に向けたTSH受容体シグナルの分子機構解明2023