HIGASHI Sadayuki 東貞行

… Alternative Names

東貞行ヒガシサダユキ

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Researcher Number	20866701
Other IDs
Affiliation (Current)	2026: 鹿児島大学, 医歯学総合研究科, 特任助教
Affiliation (based on the past Project Information) *help	2026: 鹿児島大学, 医歯学総合研究科, 特任助教 2021 – 2024: 鹿児島大学, 鹿児島大学病院, 医員
Review Section/Research Field	Principal Investigator Basic Section 53030:Respiratory medicine-related Except Principal Investigator Basic Section 52010:General internal medicine-related / Medium-sized Section 52:General internal medicine and related fields
Keywords	Except Principal Investigator miRNA / microRNA / 血管平滑筋細胞石灰化 / 心血管疾患 / 石灰化 / 血管内皮細胞 / 血管平滑筋 / 食後高血糖 / Aortic valve stenosis / 動脈硬化 / 血小板

腫瘍微小環境応答性NNMTによる肺がん多様性・治療抵抗性獲得機序の解明Principal Investigator
- Principal Investigator
  
  東貞行
- Project Period (FY)
  2026 – 2028
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Kagoshima University
Challenges in elucidating the pathogenesis of aortic valve stenosis by creating biomarkers
- Principal Investigator
  
  YAMAKUCHI MUNEKAZU
- Project Period (FY)
  2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Kagoshima University
MicroRNA elucidation of the pathogenesis of vascular smooth muscle cell calcification from postprandial hyperglycemia
- Principal Investigator
  
  藤崎知園子
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Kagoshima University
The regulatory mechanism of vascular inflammation convergence by temporal and spatial axes
- Principal Investigator
  
  Yamakuchi Munekazu
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Kagoshima University

All 2025 2024 2023 2022 2021

All Journal Article Presentation

[Journal Article] Adaptation to acidic conditions that mimic the tumor microenvironment, downregulates miR-193b-3p, and induces EMT via TGFβ2 in A549 cells2025
- Author(s)
  Higashi Sadayuki、Yamakuchi Munekazu、Hashinokuchi Hirohito、Takenouchi Kazunori、Tabaru Akito、Oyama Yoko、Fujisaki Chieko、Tanoue Kiyonori、Hashiguchi Teruto
- Journal Title
  
  PLOS ONE
  
  Volume: 20 Issue: 2 Pages: e0318811-e0318811
- DOI
  10.1371/journal.pone.0318811
- Data Source
  KAKENHI-PROJECT-23K06912
[Journal Article] The Vascular Endothelial Growth Factor-A121/Vascular Endothelial Growth Factor-A165 Ratio as a Predictor of the Therapeutic Response to Immune Checkpoint Inhibitors in Gastric Cancer2024
- Author(s)
  Hamada Yuki、Tanoue Kiyonori、Arigami Takaaki、Yamakuchi Munekazu、Okawa Masashi、Matsushita Daisuke、Takenouchi Kazunori、Yamada Shingo、Maywar Drew N.、Nakayama Chieri、Oyama Yoko、Higashi Sadayuki、Fujisaki Chieko、Hozaka Yuto、Kita Yoshiaki、Hashiguchi Teruto、Ohtsuka Takao
- Journal Title
  
  Cancers
  
  Volume: 16 Issue: 23 Pages: 3958-3958
- DOI
  10.3390/cancers16233958
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K24234, KAKENHI-PROJECT-22K16538, KAKENHI-PROJECT-24K11938
[Journal Article] VEGF-A165 is the predominant VEGF-A isoform in platelets, while VEGF-A121 is abundant in serum and plasma from healthy individuals2023
- Author(s)
  Yamakuchi Munekazu、Okawa Masashi、Takenouchi Kazunori、Bibek Aryal、Yamada Shingo、Inoue Keiichi、Higurashi Kazuhiko、Tabaru Akito、Tanoue Kiyonori、Oyama Yoko、Higashi Sadayuki、Fujisaki Chieko、Kanda Hideaki、Terasaki Hiroto、Sakamoto Taiji、Soga Yoshiharu、Hashiguchi Teruto
- Journal Title
  
  PLOS ONE
  
  Volume: 18 Issue: 4 Pages: 1-15
- DOI
  10.1371/journal.pone.0284131
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K19454, KAKENHI-PROJECT-22K07388, KAKENHI-PROJECT-21K11626, KAKENHI-PROJECT-21H03095, KAKENHI-PROJECT-23K24234
[Journal Article] Anti-ganglionic acetylcholine receptor antibodies in functional neurological symptom disorder/conversion disorder2023
- Author(s)
  Nagata Ryusei、Matsuura Eiji、Nozuma Satoshi、Dozono Mika、Noguchi Yutaka、Ando Masahiro、Hiramatsu Yu、Kodama Daisuke、Tanaka Masakazu、Kubota Ryuji、Yamakuchi Munekazu、Higuchi Yujiro、Sakiyama Yusuke、Arata Hitoshi、Higashi Keiko、Hashiguchi Teruto、Nakane Shunya、Takashima Hiroshi
- Journal Title
  
  Frontiers in Neurology
  
  Volume: 14 Pages: 01-07
- DOI
  10.3389/fneur.2023.1137958
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K19454, KAKENHI-PROJECT-23K24234, KAKENHI-PROJECT-23K24380
[Journal Article] Neutrophil-Derived MicroRNA-1290 Promotes Keratinocyte Proliferation in Psoriasis2023
- Author(s)
  Higashi Y, Yamakuchi M, Ibusuki A, Okubo A, Fukushige T, Hashiguchi T, Kanekura T.
- Journal Title
  
  J Invest Dermatol
  
  Volume: S0022-202X(23) Issue: 7 Pages: 1471-1478.e6
- DOI
  10.1016/j.jid.2023.10.042
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08329, KAKENHI-PROJECT-23K24234, KAKENHI-PROJECT-22K08385
[Presentation] 血漿中,血小板内のVEGF-A121とVEGF-A165の動態についての検討2024
- Author(s)
  山口宗一, 大川政士, 竹之内和則, 東貞行, 藤崎知園子, 大山陽子, 田上聖徳, 田原明人, 橋口照人
- Organizer
  第46回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24234
[Presentation] 乾癬の病態に関するマイクロRNAの役割2024
- Author(s)
  山口宗一, 東裕子, 竹之内和則, 橋口照人
- Organizer
  第64回日本臨床化学会年次学術集会
- Data Source
  KAKENHI-PROJECT-23K24234
[Presentation] 大腸癌患者におけるベバシズマブ投与前後における血漿、血清中VEGF-Aアイソフォーム濃度の検討2024
- Author(s)
  田原明人, 大川政士, 山口宗一, 竹之内和則, 東貞行, 藤崎知園子, 大山陽子, 田上聖徳, 橋口照人
- Organizer
  第71回日本臨床検査医学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24234
[Presentation] チアノーゼ性先天性心疾患のグレン手術後の肺動静脈奇形に関連するmiRNAの検討2024
- Author(s)
  山口宗一, 川村順平, 竹之内和則, 大山陽子, 東貞行, 田原明人, 田上聖徳, 藤崎知園子, 橋口照人
- Organizer
  第71回日本臨床検査医学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24234
[Presentation] 大腸がん患者に対するベバシズマブ投与後の血清・血漿中VEGF121及びVEGF165の濃度変化2024
- Author(s)
  竹之内和則, 山口宗一, 東貞行, 大川政士, 橋口照人
- Organizer
  第64回日本臨床化学会年次学術集会
- Data Source
  KAKENHI-PROJECT-23K24234
[Presentation] ベバシズマブ治療による血漿,血清,血小板中のVEGF-A121変化の検討2024
- Author(s)
  山口宗一, 大川政士, 竹之内和則, 東貞行, 大山陽子, 藤崎知園子, 田上聖徳, 田原明人, 橋口照人
- Organizer
  第25回日本検査血液学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24234
[Presentation] Investigation of differences in levels of VEGF-A121 and VEGF-A165 in plasma, serum, and platelets2024
- Author(s)
  M. Yamakuchi, M. Okawa, K. Takenouchi, S. Higashi, C. Fujisaki, A. Tabaru, Y. Oyama, K. Tanoue, T. Hashiguchi
- Organizer
  ISTH 2024
- Data Source
  KAKENHI-PROJECT-23K24234
[Presentation] 血栓止血領域red hot topics　血栓止血検査のピットフォール　軽症血友病,自己免疫性後天性凝固因子欠乏症,FDPの標準化2024
- Author(s)
  橋口照人, 山口宗一, 東貞行, 藤崎知園子
- Organizer
  第25回日本検査血液学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24234
[Presentation] 血漿、血清中と血小板内のVEGF-A121 とVEGF-A165の検討　－VEGF-Aアイソフォーム特異的ELISAの構築－2023
- Author(s)
  山口宗一、大川政士、竹之内和則、東貞行、藤崎知園子、大山陽子、田上聖徳、田原明人、橋口照人
- Organizer
  日本医療検査科学会第55回大会
- Data Source
  KAKENHI-PROJECT-23K24234
[Presentation] MicroRNA and granulocyte and monocyte adsorption apheresis (GMA) on Neutrophilic skin diseases2023
- Author(s)
  Higashi Y, Yamakuchi M, Fukushige T, Hashiguchi T, Kanekura T.
- Organizer
  First international societies for investigative dermatology meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24234
[Presentation] VEGF-A121とVEGF-A165の血漿、血清、血小板中の定量比較解析2023
- Author(s)
  藤崎知園子, 山口宗一, 大川政士, 竹之内和則, 東貞行, 田上聖徳, 田原明人, 大山陽子, 橋口照人
- Organizer
  第70回日本臨床検査医学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24234
[Presentation] 乾癬性関節炎における好中球関連マイクロRNAの検討2022
- Author(s)
  山口宗一、東裕子、竹之内和則、大山陽子、東貞行、藤崎知園子、田上聖徳、金蔵拓郎、橋口照人
- Organizer
  第44回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-21K19454
[Presentation] 乾癬性関節炎における好中球関連マイクロRNAの検討2022
- Author(s)
  山口宗一、東裕子、竹之内和則、大山陽子、東貞行、藤崎知園子、田上聖徳、金蔵拓郎、橋口照人
- Organizer
  第44回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24234
[Presentation] 血清、血漿、血小板におけるVEGF-A 121、165アイソフォームの比較定量2021
- Author(s)
  大川政士, 山口宗一, 竹之内和則, 東貞行, 井上恵一, 山田晋吾, 橋口照人
- Organizer
  第22回日本検査血液学会学術集会
- Data Source
  KAKENHI-PROJECT-21K19454
[Presentation] 血中microRNA-126と血小板VEGF-Aの相互関連性についての検討2021
- Author(s)
  山口宗一, 向原公介, 上田英昭, 大川政士, 松本和久, 竹之内和則, 大山陽子, 東貞行, 藤崎知園子, 井本浩, 橋口照人
- Organizer
  日本医療検査医学会第54回大会
- Data Source
  KAKENHI-PROJECT-21K19454
[Presentation] 血管平滑筋細胞石灰化のmiRNA依存性制御機構の検討2021
- Author(s)
  山口宗一, 上田英昭, 向原公介, 松本和久, 大川政士, 竹之内和則, 大山陽子, 東貞行, 藤崎知園子, 井本浩, 橋口照人
- Organizer
  第43回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-21K19454

1. Yamakuchi Munekazu (20325814)

# of Collaborated Projects: 3 results

# of Collaborated Products: 20 results
2. 橋口照人 (70250917)

# of Collaborated Projects: 3 results

# of Collaborated Products: 20 results
3. 丸山征郎 (20082282)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 大山陽子 (20583470)

# of Collaborated Projects: 2 results

# of Collaborated Products: 13 results
5. 竹之内和則 (30646758)

# of Collaborated Projects: 2 results

# of Collaborated Products: 16 results
6. 上田英昭 (50598274)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 藤崎知園子 (70973452)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. 田上聖徳 (50721031)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. KANEKURA Takuro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HIGASHI Sadayuki 東 貞行

東 貞行 ヒガシ サダユキ

Research Projects

Research Products

Co-Researchers

腫瘍微小環境応答性NNMTによる肺がん多様性・治療抵抗性獲得機序の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Challenges in elucidating the pathogenesis of aortic valve stenosis by creating biomarkers

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

MicroRNA elucidation of the pathogenesis of vascular smooth muscle cell calcification from postprandial hyperglycemia

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The regulatory mechanism of vascular inflammation convergence by temporal and spatial axes

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Adaptation to acidic conditions that mimic the tumor microenvironment, downregulates miR-193b-3p, and induces EMT via TGFβ2 in A549 cells2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Vascular Endothelial Growth Factor-A121/Vascular Endothelial Growth Factor-A165 Ratio as a Predictor of the Therapeutic Response to Immune Checkpoint Inhibitors in Gastric Cancer2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] VEGF-A165 is the predominant VEGF-A isoform in platelets, while VEGF-A121 is abundant in serum and plasma from healthy individuals2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Anti-ganglionic acetylcholine receptor antibodies in functional neurological symptom disorder/conversion disorder2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Neutrophil-Derived MicroRNA-1290 Promotes Keratinocyte Proliferation in Psoriasis2023

Author(s)

Journal Title

DOI

Data Source

[Presentation] 血漿中,血小板内のVEGF-A121とVEGF-A165の動態についての検討2024

Author(s)

Organizer

Data Source

[Presentation] 乾癬の病態に関するマイクロRNAの役割2024

Author(s)

Organizer

Data Source

[Presentation] 大腸癌患者におけるベバシズマブ投与前後における血漿、血清中VEGF-Aアイソフォーム濃度の検討2024

Author(s)

Organizer

Data Source

[Presentation] チアノーゼ性先天性心疾患のグレン手術後の肺動静脈奇形に関連するmiRNAの検討2024

Author(s)

Organizer

Data Source

[Presentation] 大腸がん患者に対するベバシズマブ投与後の血清・血漿中VEGF121及びVEGF165の濃度変化2024

Author(s)

Organizer

Data Source

[Presentation] ベバシズマブ治療による血漿,血清,血小板中のVEGF-A121変化の検討2024

Author(s)

Organizer

Data Source

[Presentation] Investigation of differences in levels of VEGF-A121 and VEGF-A165 in plasma, serum, and platelets2024

Author(s)

HIGASHI Sadayuki 東貞行

東貞行ヒガシサダユキ

[Presentation] 血栓止血領域red hot topics　血栓止血検査のピットフォール　軽症血友病,自己免疫性後天性凝固因子欠乏症,FDPの標準化2024

[Presentation] 血漿、血清中と血小板内のVEGF-A121 とVEGF-A165の検討　－VEGF-Aアイソフォーム特異的ELISAの構築－2023