MIYASHITA Shinichiro 宮下慎一郎

… Alternative Names

MIYASHITA SHIN-ICHIRO 宮下慎一郎

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Researcher Number	20883292
Affiliation (Current)	2026: 東京農業大学, 生物産業学部, 准教授
Affiliation (based on the past Project Information) *help	2026: 東京農業大学, 生物産業学部, 准教授 2020 – 2025: 東京農業大学, 生物産業学部, 助教 2024: 東京農業大学, 生物産業学部, 准教授
Review Section/Research Field	Principal Investigator Basic Section 90120:Biomaterials-related / 0801:Pharmaceutical sciences and related fields Except Principal Investigator Basic Section 49050:Bacteriology-related
Keywords	Principal Investigator ドラッグデリバリー / 凝集タンパク質 / ボツリヌス中毒 / DDS / ボツリヌス神経毒素 / 運動神経変性疾患 / 病原性タンパク質 / 細菌毒素 / VHH抗体 / 細胞内薬物送達 … More / α-Synuclein / 細胞内送達 / バイオ医薬品 / 薬物送達システム / ボツリヌス / 非ウィルス型DDS / 神経変性疾患 / 無毒化神経毒素 / ボツリヌス神経毒素様毒素 / 神経細胞変性疾患 / VHH / α-シヌクレイン / ペプチド製剤 … More Except Principal Investigator 経口毒素 / 食中毒 / ボツリヌス毒素 / ドラッグデリバリー / ボツリヌス食中毒 / ムチン / 変異 / 一次構造解析 / 等温滴定型カロリメトリー / 糖鎖 / 血球凝集素 / 経口毒性 / ボツリヌス菌 Less

人工キメラ毒素を用いた神経細胞標的DDS技術の基盤的研究Principal Investigator
- Principal Investigator
  
  宮下慎一郎
- Project Period (FY)
  2026 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 90120:Biomaterials-related
- Research Institution
  Tokyo University of Agriculture
経口毒性強化型ボツリヌス毒素複合体の体内侵入メカニズムの解明
- Principal Investigator
  
  相根義昌
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49050:Bacteriology-related
- Research Institution
  Tokyo University of Agriculture
Functional analysis of botulinum toxin complex with enhanced oral toxicity
- Principal Investigator
  
  Sagane Yoshimasa
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49050:Bacteriology-related
- Research Institution
  Tokyo University of Agriculture
Development of a degradation system targeting intracellular pathogenic proteins using chimeric toxin platformPrincipal Investigator
- Principal Investigator
  
  Miyashita Shin-Ichiro
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 90120:Biomaterials-related
- Research Institution
  Tokyo University of Agriculture
Botulinum neurotoxin-based drug delivery systems for targeting neuronsPrincipal Investigator
- Principal Investigator
  
  MIYASHITA SHIN-ICHIRO
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0801:Pharmaceutical sciences and related fields
- Research Institution
  Tokyo University of Agriculture

All 2025 2024 2023 2022 2021

All Journal Article Presentation

[Journal Article] Effects of botulinum neurotoxin-associated proteins on cellular organelle dynamics in NRK-52E cells2025
- Author(s)
  Huang I-Hsun、Miyashita Shin-Ichiro、Sagane Yoshimasa
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 765 Pages: 151800-151800
- DOI
  10.1016/j.bbrc.2025.151800
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K18198
[Journal Article] Characterization of Serotype CD Mosaic Botulinum Neurotoxin in Comparison with Serotype C and A2023
- Author(s)
  Miyashita Shin-Ichiro、Karatsu Shura、Fujiishi Mako、Huang I Hsun、Nagashima Yuki、Morobishi Tamaki、Hosoya Keita、Hata Tsuyoshi、Dong Min、Sagane Yoshimasa
- Journal Title
  
  Toxins
  
  Volume: 15 Issue: 2 Pages: 123-123
- DOI
  10.3390/toxins15020123
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K18198
[Journal Article] Variants of hemagglutinin-33 in the serotype C botulinum progenitor toxin complex boost its oral toxicity2023
- Author(s)
  Shura Karatsu, Shin-Ichiro Miyashita, Tsuyoshi Hata, I-Hsun Huang, Keita Hosoya, Yoshimasa Sagane
- Journal Title
  
  Food Preservation Science
  
  Volume: 49 Pages: 19-28
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K07057
[Presentation] Engineered Chimeric Botulinum Neurotoxin for Targeted Antibody Delivery to Treat Botulism2025
- Author(s)
  宮下慎一郎，Jie Zhang，金澤あかね，大野倫太朗，小島英恵，Min Dong，相根義昌
- Organizer
  第98回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-22K18198
[Presentation] ボツリヌス毒素の機能解析：毒素作用から生まれる新たな応用2024
- Author(s)
  宮下慎一郎、相根義昌
- Organizer
  第97回日本細菌学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-22K18198
[Presentation] キメラ毒素を用いた神経細胞内抗体送達によるボツリヌス中毒の新規治療法の開発2024
- Author(s)
  宮下慎一郎、金澤あかね、大野倫太朗、相根義昌
- Organizer
  第18回細菌学若手コロッセウム
- Data Source
  KAKENHI-PROJECT-22K18198
[Presentation] キメラ毒素を基にした神経細胞特異的抗体送達キャリアーの開発およびげっ歯類モデルにおける活性評価2024
- Author(s)
  宮下慎一郎、金澤あかね、大野倫太朗、相根義昌
- Organizer
  第97回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-22K18198
[Presentation] ボツリヌスCD型モザイク神経毒素のマウスにおける毒素活性の解析2023
- Author(s)
  宮下慎一郎、藤石眞子、唐津修羅、諸菱環、長嶋有希、畑剛士、黄インシュン、細谷圭太、相根義昌
- Organizer
  第96回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-22K18198
[Presentation] Chatacterization of serotype CD mosai botulinum neurotoxin2023
- Author(s)
  Shin-Ichiro Miyashita
- Organizer
  17th Annual botulinum research symposium（於オンライン）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K18198
[Presentation] モザイク血清型 C/D ボツリヌス神経毒素の特性評価2023
- Author(s)
  宮下慎一郎
- Organizer
  第17回細菌学会若手コロッセウム
- Data Source
  KAKENHI-PROJECT-22K18198
[Presentation] C型ボツリヌス菌Yoichi株の血球凝集素33の大腸菌組換え発現の構築と精製2023
- Author(s)
  畑剛士，宮下慎一郎，唐津修羅，黄インシュン，長島有希，諸菱環，細谷圭汰，本多亮鷹，相根義昌
- Organizer
  第96回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-22K07057
[Presentation] Chimeric BoNT-based platform for the delivery of antibodies into neurons2022
- Author(s)
  Shin-Ichiro Miyashita
- Organizer
  16t h Annual Botulinum Research Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K18198
[Presentation] Post-exposure treatment for botulism by delivery of antibodies using a chimeric toxin-based platform2022
- Author(s)
  Shin-Ichiro Miyashita, Jie Zhang, Sicai Zhang, Charles B. Shoemaker, Min Dong
- Organizer
  58th Annual Interagency Botulism Research Coordinating Committee (IBRCC) Meeting
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K18198
[Presentation] ボツリヌス神経毒素を利用した神経細胞への抗体送達によるボツリヌス中毒の治療2021
- Author(s)
  宮下　慎一郎
- Organizer
  第95回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-20K22722

1. Sagane Yoshimasa (00624660)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results

MIYASHITA Shinichiro 宮下 慎一郎

MIYASHITA SHIN-ICHIRO 宮下 慎一郎

Research Projects

Research Products

Co-Researchers

人工キメラ毒素を用いた神経細胞標的DDS技術の基盤的研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

経口毒性強化型ボツリヌス毒素複合体の体内侵入メカニズムの解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Functional analysis of botulinum toxin complex with enhanced oral toxicity

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a degradation system targeting intracellular pathogenic proteins using chimeric toxin platformPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Botulinum neurotoxin-based drug delivery systems for targeting neuronsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Effects of botulinum neurotoxin-associated proteins on cellular organelle dynamics in NRK-52E cells2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Characterization of Serotype CD Mosaic Botulinum Neurotoxin in Comparison with Serotype C and A2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Variants of hemagglutinin-33 in the serotype C botulinum progenitor toxin complex boost its oral toxicity2023

Author(s)

Journal Title

Data Source

[Presentation] Engineered Chimeric Botulinum Neurotoxin for Targeted Antibody Delivery to Treat Botulism2025

Author(s)

Organizer

Data Source

[Presentation] ボツリヌス毒素の機能解析：毒素作用から生まれる新たな応用2024

Author(s)

Organizer

Data Source

[Presentation] キメラ毒素を用いた神経細胞内抗体送達によるボツリヌス中毒の新規治療法の開発2024

Author(s)

Organizer

Data Source

[Presentation] キメラ毒素を基にした神経細胞特異的抗体送達キャリアーの開発およびげっ歯類モデルにおける活性評価2024

Author(s)

Organizer

Data Source

[Presentation] ボツリヌスCD型モザイク神経毒素のマウスにおける毒素活性の解析2023

Author(s)

Organizer

Data Source

[Presentation] Chatacterization of serotype CD mosai botulinum neurotoxin2023

Author(s)

Organizer

Data Source

[Presentation] モザイク血清型 C/D ボツリヌス神経毒素の特性評価2023

Author(s)

Organizer

Data Source

[Presentation] C型ボツリヌス菌Yoichi株の血球凝集素33の大腸菌組換え発現の構築と精製2023

Author(s)

Organizer

MIYASHITA Shinichiro 宮下慎一郎

MIYASHITA SHIN-ICHIRO 宮下慎一郎