Mu Anfeng 牟安峰

… Alternative Names

MU A 牟安峰

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Researcher Number	20894455
Other IDs
Affiliation (Current)	2025: 京都大学, 生命科学研究科, 助教
Affiliation (based on the past Project Information) *help	2025: 京都大学, 生命科学研究科, 助教 2023: 京都大学, 生命科学研究科, 助教 2021 – 2023: 京都大学, 生命科学研究科, 特定助教 2020: 京都大学, 生命科学研究科, 教務補佐員
Review Section/Research Field	Principal Investigator Basic Section 48040:Medical biochemistry-related Except Principal Investigator Basic Section 49010:Pathological biochemistry-related / Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
Keywords	Principal Investigator UBE2T / Fanconi anemia / iPSC / FANCD2 / ゲノム不安定性 / ALDH2 / ADH5 / 遺伝性骨髄不全症候群 / 複製ストレス / 骨髄不全 … More / formaldehyde / ホルムアルデヒド / ADD / 造血分化 / ADDS … More Except Principal Investigator DNA損傷 / 複製フォーク停止 / FANCD2 / 複製フォーク分解 / ファンコニ貧血 / SLFNファミリー / DNAファイバー法 / 癌化学療法 / MRE11 / DNA2 / RAD51 / 複製フォーク / 複製ストレス / SLFN11 / 脱メチル化酵素 / エピジェネティックリプログラミング / アルデヒド / リプログラミング / iPS細胞 / ゲノム損傷 / フォルムアルデヒド / エピゲノム再構成 / ADD syndrome / ADD症候群 / 脱メチル化 / reprogramming / iPS cells / Fanconi anemia / ALDH2 / ADH5 / iPS 細胞 / エピゲネティック再構築 / ホルムアルデヒド / DNA 損傷 Less

遺伝性骨髄不全症候群の分子メカニズム解明と治療法開発Principal Investigator
- Principal Investigator
  
  牟安峰
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Kyoto University
Fanconi anemia経路に着目したiPS細胞における高レベル複製ストレスの原因解明Principal Investigator
- Principal Investigator
  
  牟安峰
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Kyoto University
Investigation of pathology and therapeutic approaches targeting ADH5/ALDH2 in iPSC models of Bone Marrow Failure SyndromePrincipal Investigator
- Principal Investigator
  
  MU A
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Kyoto University
Genome-stabilizing activity of aldehyde catalyzing enzymes that support epigenetic reprogramming
- Principal Investigator
  
  Takata Minoru
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
- Research Institution
  Kyoto University
The role of SLFN11 gene that determines DNA damage sensitivity at the stalled replication forks
- Principal Investigator
  
  Takata Minoru
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Kyoto University

All 2023 2022 2021 2020

All Journal Article Presentation

[Journal Article] Fanconi anemia and Aldehyde Degradation Deficiency Syndrome: Metabolism and DNA repair protect the genome and hematopoiesis from endogenous DNA damage2023
- Author(s)
  Mu Anfeng、Hira Asuka、Mori Minako、Okamoto Yusuke、Takata Minoru
- Journal Title
  
  DNA Repair
  
  Volume: 130 Pages: 103546-103546
- DOI
  10.1016/j.dnarep.2023.103546
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K14452, KAKENHI-PROJECT-20K21394, KAKENHI-PROJECT-21K15362
[Journal Article] Mouse Slfn8 and Slfn9 genes complement human cells lacking SLFN11 during the replication stress response2023
- Author(s)
  Alvi Erin、Mochizuki Ayako L.、Katsuki Yoko、Ogawa Minori、Qi Fei、Okamoto Yusuke、Takata Minoru、Mu Anfeng
- Journal Title
  
  Communications Biology
  
  Volume: 6 Issue: 1 Pages: 1-12
- DOI
  10.1038/s42003-023-05406-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K14452, KAKENHI-PROJECT-23K11419, KAKENHI-PROJECT-20K21394, KAKENHI-PROJECT-21K15362
[Journal Article] Effects of the major formaldehyde catalyzer ADH5 on phenotypes of fanconi anemia zebrafish model2023
- Author(s)
  Mu Anfeng、Cao Zimu、Huang Denggao、Hosokawa Hiroshi、Maegawa Shingo、Takata Minoru
- Journal Title
  
  Molecular Biology Reports
  
  Volume: 50 Issue: 10 Pages: 8385-8395
- DOI
  10.1007/s11033-023-08696-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K14452, KAKENHI-PROJECT-20K21394, KAKENHI-PROJECT-21K15362
[Journal Article] The ribonuclease domain function is dispensable for <scp>SLFN11</scp> to mediate cell fate decision during replication stress response2023
- Author(s)
  Qi Fei、Alvi Erin、Ogawa Minori、Kobayashi Junya、Mu Anfeng、Takata Minoru
- Journal Title
  
  Genes to Cells
  
  Volume: 28 Issue: 9 Pages: 663-673
- DOI
  10.1111/gtc.13056
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K14452, KAKENHI-PROJECT-20K21394, KAKENHI-PROJECT-21K15362
[Journal Article] Lack of impact of the <scp>ALDH2</scp> rs671 variant on breast cancer development in Japanese <scp>BRCA1</scp> /2‐mutation carriers2022
- Author(s)
  Mori Tomoharu、Takata Minoru et al.
- Journal Title
  
  Cancer Medicine
  
  Volume: 12 Issue: 6 Pages: 6594-6602
- DOI
  10.1002/cam4.5430
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21394, KAKENHI-PROJECT-22K19577, KAKENHI-PROJECT-21K15362, KAKENHI-PROJECT-20H03450, KAKENHI-PROJECT-20H03748
[Journal Article] Aldehyde Degradation Deficiency (ADD) Syndrome2022
- Author(s)
  牟安峰，高田穣
- Journal Title
  
  生化学
  
  Volume: 94 Issue: 1 Pages: 122-127
- DOI
  10.14952/SEIKAGAKU.2022.940122
- ISSN
  0037-1017
- Year and Date
  2022-02-25
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-21K15362
[Journal Article] iPS細胞を用いたファンコニ貧血研究の新展開2021
- Author(s)
  牟安峰，高田穣
- Journal Title
  
  血液内科
  
  Volume: 83 Pages: 824-829
- NAID
  40022770492
- Data Source
  KAKENHI-PROJECT-21K15362
[Journal Article] Analysis of disease model iPSCs derived from patients with a novel Fanconi anemia-like IBMFS ADH5/ALDH2 deficiency.2021
- Author(s)
  Anfeng Mu, Asuka Hira, Akira Niwa, Mitsujiro Osawa, Kenichi Yoshida, Minako Mori, Yusuke Okamoto, Kazuko Inoue, Keita Kondo, Masato T. Kanemaki, Tomonari Matsuda, Etsuro Ito, Seiji Kojima, Tatsutoshi Nakahata, Seishi Ogawa, Keigo Tanaka, Keitaro Matsuo, Megumu K. Saito, Minoru Takata.
- Journal Title
  
  Blood
  
  Volume: 137 Issue: 15 Pages: 2021-2032
- DOI
  10.1182/blood.2020009111
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21394, KAKENHI-PROJECT-18H04039, KAKENHI-PROJECT-20H03450, KAKENHI-PUBLICLY-20H05396, KAKENHI-PROJECT-19H05656, KAKENHI-PROJECT-20H03642, KAKENHI-PROJECT-21K15362, KAKENHI-PROJECT-23K21429, KAKENHI-PROJECT-21H04719
[Journal Article] SLFN11 promotes stalled fork degradation that underlies the phenotype in Fanconi anemia cells2021
- Author(s)
  Okamoto Yusuke、Abe Masako、Mu Anfeng、Tempaku Yasuko、Rogers Colette B.、Mochizuki Ayako L.、Katsuki Yoko、Kanemaki Masato T.、Takaori-Kondo Akifumi、Sobeck Alexandra、Bielinsky Anja-Katrin、Takata Minoru
- Journal Title
  
  Blood
  
  Volume: 137 Issue: 3 Pages: 336-348
- DOI
  10.1182/blood.2019003782
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K12161, KAKENHI-PROJECT-20K21394, KAKENHI-PROJECT-20H03450, KAKENHI-PUBLICLY-20H05396, KAKENHI-PROJECT-21H04719
[Journal Article] Aldehyde degradation deficiency (ADD) syndrome: discovery of a novel fanconi anemia-like inherited BMF syndrome due to combined ADH5/ALDH2 deficiency2021
- Author(s)
  Anfeng Mu , Asuka Hira , Keitaro Matsuo , Minoru Takata
- Journal Title
  
  The Japanese journal of clinical hematology
  
  Volume: 62 Pages: 547-553
- NAID
  130008061937
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K15362
[Journal Article] Two aldehyde clearance systems are essential to prevent lethal formaldehyde accumulation in mice and humans.2020
- Author(s)
  Dingler FA†, Wang M†, Mu A† (Co-first), ....Takata M, Patel KJ.
- Journal Title
  
  Mol Cell
  
  Volume: 80 Issue: 6 Pages: 996-1012
- DOI
  10.1016/j.molcel.2020.10.012
- NAID
  120006951779
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21394, KAKENHI-INTERNATIONAL-15K21741, KAKENHI-PROJECT-19H05656, KAKENHI-PROJECT-18H04039, KAKENHI-PROJECT-20H03450
[Presentation] SLFN11による複製ストレス調節の分子機構2023
- Author(s)
  牟安峰 , 髙田穣
- Organizer
  第46回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-23K14452
[Presentation] SLFN11による複製ストレス調節の分子機構2023
- Author(s)
  牟安峰, 髙田穣
- Organizer
  第46回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-21K15362
[Presentation] Fanconi anemia and Aldehyde Degradation Deficiency (ADD) Syndrome: DNA repair and metabolism together protect the genome and hematopoiesis2023
- Author(s)
  Anfeng Mu
- Organizer
  Sussex Japan Genome Stability Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15362
[Presentation] Fanconi anemia and Aldehyde Degradation Deficiency (ADD) Syndrome2023
- Author(s)
  Anfeng Mu
- Organizer
  The 19th Ataxia-Telangiectasia workshop
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15362
[Presentation] 抗がん化学療法後の細胞運命を決定する SLFN11 遺伝子とそのファミリー2022
- Author(s)
  Minoru Takata, Anfeng Mu
- Organizer
  第81回日本がん学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03450
[Presentation] 新規骨髄不全症ADDSの発見とモデルiPS細胞による病態・治療法検討2022
- Author(s)
  牟安峰
- Organizer
  第17回血液学若手研究者勉強会（麒麟塾）
- Invited
- Data Source
  KAKENHI-PROJECT-21K15362
[Presentation] DNA 損傷感受性および複製ストレス応答増強におけるヒト SLFN11 および関連マウス遺伝子の解析2022
- Author(s)
  Minoru TAKATA, Erin Norah Corrigan ALVI, Ayako L MOCHIZUKI, Yoko KATSUKI, Minori OGAWA,Fei QI, Yusuke OKAMOTO, Anfeng MU
- Organizer
  日本放射線影響学会第65回大会
- Data Source
  KAKENHI-PROJECT-20H03450
[Presentation] SLFN11とSLFNファミリー機能の統一的理解を目指して2021
- Author(s)
  高田穰, Alvi Erin, 小川みのり, 勝木陽子, 岡本祐介, Canela Andres, 望月綾子, 牟安峰
- Organizer
  2021年日本分子生物学会第44回年会ワークショップ
- Data Source
  KAKENHI-PROJECT-21K15362
[Presentation] SLFN11とSLFNファミリー機能の統一的理解を目指して2021
- Author(s)
  高田穰1, Alvi Erin1, 小川みのり1, 勝木陽子1, 岡本祐介1, Canela Andres1,2, 望月綾子1, 牟安峰
- Organizer
  2021年日本分子生物学会第44回年会ワークショップ　「あなたの知らないSLFN11の世界」オーガナイザー：村井純子（慶應義塾大学）高田穰（京都大学）
- Invited
- Data Source
  KAKENHI-PROJECT-20H03450
[Presentation] SLFN11 promotes stalled fork degradation that underlies the phenotype in Fanconi anemia cells.2021
- Author(s)
  岡本裕介1,3、牟安峰１,2、望月綾子１,2, 勝木陽子１,2, 高折晃史3、高田穰
- Organizer
  第16回血液学若手研究者勉強会（麒麟塾）
- Invited
- Data Source
  KAKENHI-PROJECT-20K21394
[Presentation] 新規遺伝性骨髄不全症アルデヒド分解不全(ADD)症候群の発見：代謝異常によって引き起こされるゲノム不安定性2021
- Author(s)
  牟安峰1, 平明日香1, 丹羽明2, 大澤光次郎2, 森美奈子1, 岡本裕介1, 齋藤潤2, 高田穣
- Organizer
  2021年日本分子生物学会第44回年会ワークショップ「ゲノム安定性：その破綻を誘導する分子機構と破綻によりおこるゲノム異常」オーガナイザー：中田慎一郎（大阪大学）、廣田耕志（東京都立大学）
- Data Source
  KAKENHI-PROJECT-20H03450
[Presentation] SLFN11 promotes stalled fork degradation that underlies the phenotype in Fanconi anemia cells.2021
- Author(s)
  岡本裕介1,3、牟安峰１,2、望月綾子１,2, 勝木陽子１,2, 高折晃史3、高田穰
- Organizer
  第16回血液学若手研究者勉強会（麒麟塾）
- Invited
- Data Source
  KAKENHI-PROJECT-20H03450
[Presentation] 新規遺伝性骨髄不全症アルデヒド分解不全(ADD)症候群の発見：代謝異常によって引き起こされるゲノム不安定性2021
- Author(s)
  牟安峰1, 平明日香1, 丹羽明2, 大澤光次郎2, 森美奈子1, 岡本裕介1, 齋藤潤2, 高田穣
- Organizer
  2021年日本分子生物学会第44回年会ワークショップ「ゲノム安定性：その破綻を誘導する分子機構と破綻によりおこるゲノム異常」オーガナイザー：中田慎一郎（大阪大学）、廣田耕志（東京都立大学
- Data Source
  KAKENHI-PROJECT-20K21394
[Presentation] 新規遺伝性骨髄不全症アルデヒド分解不全(ADD)症候群の発見：代謝異常によって引き起こされるゲノム不安定性2021
- Author(s)
  牟安峰, 平明日香, 丹羽明, 大澤光次郎, 森美奈子, 岡本裕介, 齋藤潤, 高田穣
- Organizer
  2021年日本分子生物学会第44回年会ワークショップ
- Data Source
  KAKENHI-PROJECT-21K15362
[Presentation] SLFN11 promotes stalled fork degradation that underlies the phenotype in Fanconi anemia cells.2021
- Author(s)
  岡本裕介、牟安峰、望月綾子、勝木陽子、高折晃史、高田穰
- Organizer
  第16回血液学若手研究者勉強会（麒麟塾）
- Data Source
  KAKENHI-PROJECT-21K15362
[Presentation] Discovery of a novel FA-like disorder Aldehyde Degradation Deficiency (ADD) Syndrome caused by ADH5/ALDH2 mutations2021
- Author(s)
  Anfeng Mu, Asuka Hira, Akira Niwa, Mitsujiro Osawa, Minako Mori, Yusuke Okamoto, Megumu K. Saito, Minoru Takata.
- Organizer
  2021Fanconi anemia Research Fund Scientific Symposium.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03450
[Presentation] Discovery of a novel FA-like disorder Aldehyde Degradation Deficiency (ADD) Syndrome caused by ADH5/ALDH2 mutations.2021
- Author(s)
  Anfeng Mu, Asuka Hira, Akira Niwa, Mitsujiro Osawa, Minako Mori, Yusuke Okamoto, Megumu K. Saito, Minoru Takata.
- Organizer
  2021Fanconi anemia Research Fund Scientific Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21394
[Presentation] Discovery of a novel FA-like disorder Aldehyde Degradation Deficiency (ADD) Syndrome caused by ADH5/ALDH2 mutations.2021
- Author(s)
  Anfeng Mu, Asuka Hira, Akira Niwa, Mitsujiro Osawa, Minako Mori, Yusuke Okamoto, Megumu K. Saito, Minoru Takata.
- Organizer
  2021Fanconi anemia Research Fund Scientific Symposium.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15362
[Presentation] Loss of SLFN11 gene expression rescues the Fanconi anemia phenotype by stabilizing stalled replication forks.2020
- Author(s)
  Yusuke Okamoto, Masako Abe, Mu Anfeng, Yasuko Tempaku, Colette B. Rogers, Ayako L. Mochizuki, Yoko Katsuki1, Masato T. Kanemaki, Akifumi Takaori-Kondo, Alex Sobeck, Anja-Katrin Bielinsky, and Minoru Takata.
- Organizer
  Fanconi Anemia Research Fund Virtual Scientific Symposia
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03450
[Presentation] Loss of SLFN11 gene expression rescues the Fanconi anemia phenotype by stabilizing stalled replication forks.2020
- Author(s)
  Yusuke Okamoto, Masako Abe, Mu Anfeng, Yasuko Tempaku, Colette B. Rogers, Ayako L. Mochizuki, Yoko Katsuki1, Masato T. Kanemaki, Akifumi Takaori-Kondo, Alex Sobeck, Anja-Katrin Bielinsky, and Minoru Takata.
- Organizer
  Fanconi Anemia Research Fund Virtual Scientific Symposia.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21394

1. Takata Minoru (30281728)

# of Collaborated Projects: 2 results

# of Collaborated Products: 14 results
2. 勝木陽子 (00645377)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
3. 望月綾子 (80817148)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results

Mu Anfeng 牟 安峰

MU A 牟 安峰

Research Projects

Research Products

Co-Researchers

遺伝性骨髄不全症候群の分子メカニズム解明と治療法開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Fanconi anemia経路に着目したiPS細胞における高レベル複製ストレスの原因解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of pathology and therapeutic approaches targeting ADH5/ALDH2 in iPSC models of Bone Marrow Failure SyndromePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Genome-stabilizing activity of aldehyde catalyzing enzymes that support epigenetic reprogramming

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The role of SLFN11 gene that determines DNA damage sensitivity at the stalled replication forks

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Fanconi anemia and Aldehyde Degradation Deficiency Syndrome: Metabolism and DNA repair protect the genome and hematopoiesis from endogenous DNA damage2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mouse Slfn8 and Slfn9 genes complement human cells lacking SLFN11 during the replication stress response2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effects of the major formaldehyde catalyzer ADH5 on phenotypes of fanconi anemia zebrafish model2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The ribonuclease domain function is dispensable for <scp>SLFN11</scp> to mediate cell fate decision during replication stress response2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Lack of impact of the <scp>ALDH2</scp> rs671 variant on breast cancer development in Japanese <scp>BRCA1</scp> /2‐mutation carriers2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Aldehyde Degradation Deficiency (ADD) Syndrome2022

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] iPS細胞を用いたファンコニ貧血研究の新展開2021

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Analysis of disease model iPSCs derived from patients with a novel Fanconi anemia-like IBMFS ADH5/ALDH2 deficiency.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] SLFN11 promotes stalled fork degradation that underlies the phenotype in Fanconi anemia cells2021

Author(s)

Mu Anfeng 牟安峰

MU A 牟安峰

[Presentation] DNA 損傷感受性および複製ストレス応答増強におけるヒト SLFN11 および関連マウス遺伝子の解析2022