Naruse Hiroya 成瀬紘也

Researcher Number	20898241
Other IDs
Affiliation (Current)	2026: 東京大学, 医学部附属病院, 助教
Affiliation (based on the past Project Information) *help	2024: 東京大学, 医学部附属病院, 助教 2022 – 2023: 東京大学, 医学部附属病院, 特任助教
Review Section/Research Field	Principal Investigator Basic Section 52020:Neurology-related
Keywords	Principal Investigator 筋萎縮性側索硬化症 / 脂質分析 / オートファジー

若年発症のALSのゲノム基盤と病態の解明Principal Investigator
- Principal Investigator
  
  成瀬紘也
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  The University of Tokyo
Uncovering ALS mechanisms and drug targets linked to autophagy disturbancesPrincipal Investigator
- Principal Investigator
  
  Naruse Hiroya
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  The University of Tokyo

All 2024 2023 2022

All Journal Article Presentation

[Journal Article] An autopsy case report of amyotrophic lateral sclerosis with unusual basophilic inclusions exhibiting immunopositivity for optineurin2024
- Author(s)
  Kashiwagi-Hakozaki Mayu、Ikemura Masako、Naruse Hiroya、Takahashi Yuji、Toda Tatsushi、Ushiku Tetsuo
- Journal Title
  
  Pathology International
  
  Volume: 75 Issue: 2 Pages: 121-123
- DOI
  10.1111/pin.13501
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24K18698
[Journal Article] <scp><i>SPTLC2</i></scp> variants are associated with early‐onset <scp>ALS</scp> and <scp>FTD</scp> due to aberrant sphingolipid synthesis2024
- Author(s)
  Naruse H、Ishiura H、Takiyama Y、Morishita S、Tsuji S、Toda T, et al.
- Journal Title
  
  Annals of Clinical and Translational Neurology
  
  Volume: - Issue: 4 Pages: 946-957
- DOI
  10.1002/acn3.52013
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07456, KAKENHI-PROJECT-22K15724, KAKENHI-PROJECT-23H00418, KAKENHI-PROJECT-22H04923, KAKENHI-PROJECT-21K07512, KAKENHI-PROJECT-23K27514, KAKENHI-PROJECT-24K18698
[Journal Article] Genetic and functional analyses of SPTLC1 in juvenile amyotrophic lateral sclerosis2024
- Author(s)
  Okubo So、Naruse Hiroya、Ishiura Hiroyuki、Sudo Atsushi、Esaki Kayoko、Mitsui Jun、Matsukawa Takashi、Satake Wataru、Greimel Peter、Shingai Nanoka、Oya Yasushi、Yoshikawa Takeo、Tsuji Shoji、Toda Tatsushi
- Journal Title
  
  Journal of Neurology
  
  Volume: 272 Issue: 1 Pages: 36-36
- DOI
  10.1007/s00415-024-12776-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K27514, KAKENHI-PROJECT-24K18698, KAKENHI-PROJECT-24K18699
[Journal Article] A novel <i>TBK1</i> loss-of-function variant associated with ALS and parkinsonism phenotypes2024
- Author(s)
  Naruse Hiroya、Iseki Chifumi、Mitsui Jun、Miki Jun、Nagasawa Hikaru、Kurokawa Katsuro、Kobayashi Ryota、Sato Hiroyasu、Goto Jun、Satake Wataru、Ishiura Hiroyuki、Tsuji Shoji、Ohta Yasuyuki、Toda Tatsushi
- Journal Title
  
  Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
  
  Volume: 25 Issue: 7-8 Pages: 791-794
- DOI
  10.1080/21678421.2024.2374374
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07464, KAKENHI-PROJECT-23K27514, KAKENHI-PROJECT-22K07552, KAKENHI-PROJECT-24K18698
[Journal Article] Clinical features of a family with late‐onset distal hereditary motor neuropathy harboring p.Pro39Leu variant of HSPB12023
- Author(s)
  Naruse Hiroya、Okubo So、Sudo Atsushi、Mitsui Jun、Mikata Takashi、Ishiura Hiroyuki、Morishita Shinichi、Tsuji Shoji、Toda Tatsushi
- Journal Title
  
  Journal of the Peripheral Nervous System
  
  Volume: 28 Issue: 3 Pages: 518-521
- DOI
  10.1111/jns.12567
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K15724, KAKENHI-PROJECT-23K27514
[Journal Article] LONRF2 is a protein quality control ubiquitin ligase whose deficiency causes late-onset neurological deficits2023
- Author(s)
  Li Dan、Johmura Yoshikazu、Morimoto Satoru et al.
- Journal Title
  
  Nature Aging
  
  Volume: 3 Issue: 8 Pages: 1001-1019
- DOI
  10.1038/s43587-023-00464-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15736, KAKENHI-PROJECT-23K07345, KAKENHI-PROJECT-19K08267, KAKENHI-PROJECT-20K06464, KAKENHI-PROJECT-21K07411, KAKENHI-PROJECT-22K19398, KAKENHI-PROJECT-22K15724, KAKENHI-PROJECT-20H03162, KAKENHI-ORGANIZER-19H05739, KAKENHI-PLANNED-21H05278, KAKENHI-ORGANIZER-23H03834, KAKENHI-PLANNED-23H03835, KAKENHI-PROJECT-20H00485, KAKENHI-PROJECT-23K20328, KAKENHI-PROJECT-23K27084, KAKENHI-PROJECT-23K27376, KAKENHI-PROJECT-23H00418
[Journal Article] Noncanonical splice‐site variant in peripheral myelin protein 22 gene (PMP22) in a patient with hereditary neuropathy with liability to pressure palsies2023
- Author(s)
  Kawamoto Norifumi、Hamada Yuichi、Kobayashi Shunsuke、Naruse Hiroya、Ishiura Hiroyuki、Matsukawa Takashi、Mitsui Jun、Tsuji Shoji、Sonoo Masahiro、Toda Tatsushi
- Journal Title
  
  Journal of the Peripheral Nervous System
  
  Volume: 28 Issue: 3 Pages: 513-517
- DOI
  10.1111/jns.12558
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K15724, KAKENHI-PROJECT-23K27514
[Journal Article] Valosin-containing protein Asp395Gly mutation in a patient with frontotemporal dementia: a case report2022
- Author(s)
  Kobayashi Ryota、Naruse Hiroya、Kawakatsu Shinobu、Iseki Chifumi、Suzuki Yuya、Koyama Shingo、Morioka Daichi、Ishiura Hiroyuki、Mitsui Jun、Ohta Yasuyuki、Tsuji Shoji、Toda Tatsushi、Otani Koichi
- Journal Title
  
  BMC Neurology
  
  Volume: 22 Issue: 1 Pages: 1-6
- DOI
  10.1186/s12883-022-02951-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K07552, KAKENHI-PROJECT-22K15724
[Journal Article] Clinical and electrophysiological findings of facial palsy in a case of hereditary gelsolin amyloidosis2022
- Author(s)
  Kaoru Yamakawa, Hironobu Nishijima, Akatsuki Kubota, Hiroya Naruse, Shintaro Baba, Yoko Fujimaki, Kenji Kondo, Tatsushi Toda, Tatsuya Yamasoba
- Journal Title
  
  Auris Nasus Larynx
  
  Volume: － Issue: 2 Pages: 305-308
- DOI
  10.1016/j.anl.2022.02.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19J01720, KAKENHI-PROJECT-22K15724
[Presentation] SPTLC2 variants are associated with early-onset ALS and FTD due to aberrant sphingolipid synthesis2024
- Author(s)
  Hiroya Naruse, Hiroyuki Ishiura, Kayoko Esaki, Jun Mitsui, Wataru Satake, Yuka Machino, Yasumasa Kokubo, Hirotoshi Hamaguchi, Takeo Yoshikawa, Shoji Tsuji, Tatsushi Toda
- Organizer
  第65回日本神経学会学術大会/AOCN2024
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24K18698
[Presentation] 当施設で経験したSOD1遺伝子変異を有する筋萎縮性側索硬化症14例の臨床的検討2024
- Author(s)
  三土修一朗, 成瀬紘也, 濱田雅, 三井純, 佐竹渉, 辻省次, 戸田達史
- Organizer
  第65回日本神経学会学術大会/AOCN2024
- Data Source
  KAKENHI-PROJECT-24K18698
[Presentation] TARDBP遺伝子変異を認めた家族性ALSの家系の3症例の臨床経過の検討2024
- Author(s)
  河野智仁, 柚木太淳, 成瀬紘也, 中野由美子, 平佑貴, 松岡千加, 小坂田陽介, 野村恵美, 武本麻美, 森原隆太, 山下徹, 石浦浩之
- Organizer
  第65回日本神経学会学術大会/AOCN2024
- Data Source
  KAKENHI-PROJECT-24K18698
[Presentation] Genetic analysis and role of rare variants in ALS-causing genes in the Japanese ALS series2022
- Author(s)
  Hiroya Naruse
- Organizer
  日本人類遺伝学会第65回大会
- Invited
- Data Source
  KAKENHI-PROJECT-22K15724

1. ISHIURA Hiroyuki

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# of Collaborated Products: 1 results
2. 森岡大智

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# of Collaborated Products: 1 results
3. 川勝忍

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# of Collaborated Products: 1 results
4. 小林良太

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# of Collaborated Products: 1 results
5. 滝山嘉久

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# of Collaborated Products: 1 results
6. 森本悟

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# of Collaborated Products: 1 results
7. 佐藤秀則

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8. 伊関千書

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# of Collaborated Products: 1 results

Naruse Hiroya 成瀬 紘也

Research Projects

Research Products

Co-Researchers

若年発症のALSのゲノム基盤と病態の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Uncovering ALS mechanisms and drug targets linked to autophagy disturbancesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] An autopsy case report of amyotrophic lateral sclerosis with unusual basophilic inclusions exhibiting immunopositivity for optineurin2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] <scp><i>SPTLC2</i></scp> variants are associated with early‐onset <scp>ALS</scp> and <scp>FTD</scp> due to aberrant sphingolipid synthesis2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Genetic and functional analyses of SPTLC1 in juvenile amyotrophic lateral sclerosis2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A novel <i>TBK1</i> loss-of-function variant associated with ALS and parkinsonism phenotypes2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Clinical features of a family with late‐onset distal hereditary motor neuropathy harboring p.Pro39Leu variant of HSPB12023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] LONRF2 is a protein quality control ubiquitin ligase whose deficiency causes late-onset neurological deficits2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Noncanonical splice‐site variant in peripheral myelin protein 22 gene (PMP22) in a patient with hereditary neuropathy with liability to pressure palsies2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Valosin-containing protein Asp395Gly mutation in a patient with frontotemporal dementia: a case report2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Clinical and electrophysiological findings of facial palsy in a case of hereditary gelsolin amyloidosis2022

Author(s)

Journal Title

DOI

Data Source

[Presentation] SPTLC2 variants are associated with early-onset ALS and FTD due to aberrant sphingolipid synthesis2024

Author(s)

Organizer

Data Source

[Presentation] 当施設で経験したSOD1遺伝子変異を有する筋萎縮性側索硬化症14例の臨床的検討2024

Author(s)

Organizer

Data Source

[Presentation] TARDBP遺伝子変異を認めた家族性ALSの家系の3症例の臨床経過の検討2024

Author(s)

Organizer

Data Source

[Presentation] Genetic analysis and role of rare variants in ALS-causing genes in the Japanese ALS series2022

Author(s)

Organizer

Data Source

Naruse Hiroya 成瀬紘也