XU Minhui 徐旻恵

… Alternative Names

XU MINHUI 徐旻恵

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Researcher Number	20910201
Other IDs
Affiliation (Current)	2026: 藤田医科大学, BNCT研究センター, 講師 2026: 大阪大学, 大学院医学系研究科, 助教
Affiliation (based on the past Project Information) *help	2022 – 2024: 大阪大学, 大学院医学系研究科, 助教 2021: 大阪大学, 医学系研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 56030:Urology-related / 0802:Biomedical structure and function and related fields Except Principal Investigator Basic Section 48030:Pharmacology-related / Medium-sized Section 48:Biomedical structure and function and related fields
Keywords	Principal Investigator 免疫チェックポイント阻害薬 / がん微小環境 / SLC7A5 / アミノ酸トランスポーター / 去勢抵抗性前立腺がん / がん免疫 Except Principal Investigator シグナル情報伝達 / アミノ酸 / アミノ酸トランスポータ / アミノ酸トランスポーター … More / 細胞休眠化 / 細胞周期 / トランスポーター / 受容体 / 輸送体 Less

Mechanistic analysis of potent cell cycle control and dormancy induction by amino acid transporter inhibitors in cancer cells
- Principal Investigator
  
  Kanai Yoshikatsu
- Project Period (FY)
  2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 48030:Pharmacology-related
- Research Institution
  Osaka University
去勢抵抗性前立腺がんのLAT1阻害による免疫チェックポイント阻害薬作用増強の検討Principal Investigator
- Principal Investigator
  
  徐旻恵
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Osaka University
Elucidation of the transmembrane signal mechanism responsible for metabolic control by amino acid availability
- Principal Investigator
  
  Kanai Yoshikatsu
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 48:Biomedical structure and function and related fields
- Research Institution
  Osaka University
Enhancing Anti-tumor Effect of PD-1 Inhibitors through T-Cell Activation by Amino Acid Transporter LAT1 InhibitorPrincipal Investigator
- Principal Investigator
  
  XU MINHUI
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0802:Biomedical structure and function and related fields
- Research Institution
  Osaka University

All 2025 2024 2023 2022 2021

All Journal Article Presentation

[Journal Article] Pharmacological and structural insights into nanvuranlat, a selective LAT1 (SLC7A5) inhibitor, and its N-acetyl metabolite with implications for cancer therapy2025
- Author(s)
  Jin Chunhuan、Zhou Xinyu、Xu Minhui、Okanishi Hiroki、Ohgaki Ryuichi、Kanai Yoshikatsu
- Journal Title
  
  Scientific Reports
  
  Volume: 15 Issue: 1 Pages: 2903-2903
- DOI
  10.1038/s41598-025-87522-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K24071, KAKENHI-PROJECT-22K06856, KAKENHI-PROJECT-23K19451
[Journal Article] Structural basis of anticancer drug recognition and amino acid transport by LAT12025
- Author(s)
  Lee Yongchan、Jin Chunhuan、Ohgaki Ryuichi、Xu Minhui、Ogasawara Satoshi、Warshamanage Rangana、Yamashita Keitaro、Murshudov Garib、Nureki Osamu、Murata Takeshi、Kanai Yoshikatsu
- Journal Title
  
  Nature Communications
  
  Volume: 16 Issue: 1 Pages: 1635-1635
- DOI
  10.1038/s41467-025-56903-w
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24071, KAKENHI-PROJECT-22K06856, KAKENHI-PROJECT-23K19451
[Journal Article] L‐type amino acid transporter 1 inhibitor <scp>JPH203</scp> prevents the growth of cabazitaxel‐resistant prostate cancer by inhibiting cyclin‐dependent kinase activity2024
- Author(s)
  Rii Junryo、Sakamoto Shinichi、Mizokami Atsushi、Xu Minhui、Fujimoto Ayumi、Saito Shinpei、Koike Hidekazu、Tamura Takaaki、Arai Takayuki、Yamada Yasutaka、Goto Yusuke、Sazuka Tomokazu、Imamura Yusuke、Suzuki Kazuhiro、Kanai Yoshikatsu、Anzai Naohiko、Ichikawa Tomohiko
- Journal Title
  
  Cancer Science
  
  Volume: 115 Issue: 3 Pages: 937-953
- DOI
  10.1111/cas.16062
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K19348, KAKENHI-PROJECT-22K19404, KAKENHI-PROJECT-21K20742, KAKENHI-PROJECT-21H03065, KAKENHI-PROJECT-23K24071, KAKENHI-PROJECT-24K02575, KAKENHI-PROJECT-23K15780
[Journal Article] Identification of tumor-suppressive miRNAs that target amino acid transporter LAT1 and exhibit anti-proliferative effects on cholangiocarcinoma cells2024
- Author(s)
  Liu Xingming、Nishikubo Kou、Ohgaki Ryuichi、Okanishi Hiroki、Okuda Suguru、Xu Minhui、Kanai Yoshikatsu
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: － Issue: 4 Pages: 301-311
- DOI
  10.1016/j.jphs.2024.02.012
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06856, KAKENHI-PROJECT-22K19404, KAKENHI-PROJECT-21K20742, KAKENHI-PROJECT-22KJ2171, KAKENHI-PROJECT-23K24071
[Journal Article] Structure activity characteristics of phenylalanine analogs selectively transported by L-type amino acid transporter 1 (LAT1)2024
- Author(s)
  Chen Sihui、Jin Chunhuan、Ohgaki Ryuichi、Xu Minhui、Okanishi Hiroki、Kanai Yoshikatsu
- Journal Title
  
  Scientific Reports
  
  Volume: 14 Issue: 1 Pages: 1-13
- DOI
  10.1038/s41598-024-55252-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K19451, KAKENHI-PROJECT-22K06856, KAKENHI-PROJECT-22K19404, KAKENHI-PROJECT-21K20742, KAKENHI-PROJECT-23K24071
[Journal Article] Amino acid transporter LAT1 is expressed on cancer cell-derived exosomes with potential as a diagnostic and prognostic biomarker2024
- Author(s)
  Liu Yumiao、Ohgaki Ryuichi、Okanishi Hiroki、Xu Minhui、Kanai Yoshikatsu
- Journal Title
  
  Scientific Reports
  
  Volume: 14 Issue: 1 Pages: 28458-28458
- DOI
  10.1038/s41598-024-79425-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K24071, KAKENHI-PROJECT-22K06856
[Journal Article] LAT1 expression in colorectal cancer cells is unresponsive to HIF-1/2α accumulation under experimental hypoxia2024
- Author(s)
  Ohgaki Ryuichi、Hirase Yuma、Xu Minhui、Okanishi Hiroki、Kanai Yoshikatsu
- Journal Title
  
  Scientific Reports
  
  Volume: 14 Issue: 1 Pages: 19635-19635
- DOI
  10.1038/s41598-024-70603-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K24071, KAKENHI-PROJECT-22K06856
[Journal Article] Upregulation of ATF4 mediates the cellular adaptation to pharmacologic inhibition of amino acid transporter LAT1 in pancreatic ductal adenocarcinoma cells2024
- Author(s)
  Ma Yu、Okuda Suguru、Okanishi Hiroki、Xu Minhui、Jin Chunhuan、Endou Hitoshi、Ohgaki Ryuichi、Kanai Yoshikatsu
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 155 Issue: 1 Pages: 14-20
- DOI
  10.1016/j.jphs.2024.03.001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K19451, KAKENHI-PROJECT-22K06856, KAKENHI-PROJECT-22K19404, KAKENHI-PROJECT-21K20742, KAKENHI-PROJECT-23K24071
[Journal Article] The <scp>LAT1</scp> inhibitor <scp>JPH203</scp> suppresses the growth of castration‐resistant prostate cancer through a <scp>CD24</scp>‐mediated mechanism2024
- Author(s)
  Saito S, Ando K, Sakamoto S, Xu M, Yamada Y, Rii J, Kanaoka S, Wei J, Zhao X, Pae S, Kanesaka M, Goto Y, Sazuka T, Imamura Y, Reien Y, Hamaguchi-Suzuki N, Saito S, Hirayama Y, Hashimoto H, Kanai Y, Ichikawa T, Anzai N.
- Journal Title
  
  Cancer Science
  
  Volume: - Issue: 7 Pages: 2461-2472
- DOI
  10.1111/cas.16191
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K19348, KAKENHI-PROJECT-21H03065, KAKENHI-PROJECT-23K24071, KAKENHI-PROJECT-22K06840, KAKENHI-PROJECT-24K02575, KAKENHI-PROJECT-23K15757, KAKENHI-PROJECT-24K19646
[Journal Article] Inhibition of amino acid transporter LAT1 in cancer cells suppresses G0/G1-S transition by downregulating cyclin D1 via p38 MAPK activation2024
- Author(s)
  Zhou Xinyu、Ohgaki Ryuichi、Jin Chunhuan、Xu Minhui、Okanishi Hiroki、Endou Hitoshi、Kanai Yoshikatsu
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 154 Issue: 3 Pages: 182-191
- DOI
  10.1016/j.jphs.2024.01.007
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K19451, KAKENHI-PROJECT-22K06856, KAKENHI-PROJECT-22K19404, KAKENHI-PROJECT-21K20742, KAKENHI-PROJECT-23K24071
[Journal Article] Combination effects of amino acid transporter LAT1 inhibitor nanvuranlat and cytotoxic anticancer drug gemcitabine on pancreatic and biliary tract cancer cells2023
- Author(s)
  Nishikubo Kou、Ohgaki Ryuichi、Liu Xingming、Okanishi Hiroki、Xu Minhui、Endou Hitoshi、Kanai Yoshikatsu
- Journal Title
  
  Cancer Cell International
  
  Volume: 23 Issue: 1 Pages: 116-116
- DOI
  10.1186/s12935-023-02957-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06856, KAKENHI-PROJECT-22K19404, KAKENHI-PROJECT-21K20742, KAKENHI-PROJECT-22KJ2171, KAKENHI-PROJECT-23K24071
[Journal Article] Inhibition of cancer-type amino acid transporter LAT1 suppresses B16-F10 melanoma metastasis in mouse models2023
- Author(s)
  Shi Zitong、Kaneda-Nakashima Kazuko、Ohgaki Ryuichi、Xu Minhui、Okanishi Hiroki、Endou Hitoshi、Nagamori Shushi、Kanai Yoshikatsu
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 13943-13943
- DOI
  10.1038/s41598-023-41096-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06856, KAKENHI-PROJECT-21K07619, KAKENHI-PROJECT-22K19404, KAKENHI-PROJECT-21K20742, KAKENHI-PROJECT-21H03365, KAKENHI-PROJECT-23K24071
[Journal Article] Functional coupling of organic anion transporter OAT10 (SLC22A13) and monocarboxylate transporter MCT1 (SLC16A1) influencing the transport function of OAT102022
- Author(s)
  Ohtsu Naoko、Ohgaki Ryuichi、Jin Chunhuan、Xu Minhui、Okanishi Hiroki、Takahashi Ryo、Matsui Akiko、Kishimoto Wataru、Ishiguro Naoki、Kanai Yoshikatsu
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 150 Issue: 1 Pages: 41-48
- DOI
  10.1016/j.jphs.2022.06.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19404, KAKENHI-PROJECT-21K20742, KAKENHI-PROJECT-23K24071
[Journal Article] Targeting L-type amino acid transporter 1 in urological malignancy: Current status and future perspective2022
- Author(s)
  Pae Sangjon、Sakamoto Shinichi、Zhao Xue、Saito Shinpei、Tamura Takaaki、Imamura Yusuke、Sazuka Tomokazu、Reien Yoshie、Hirayama Yuri、Hashimoto Hirofumi、Kanai Yoshikatsu、Ichikawa Tomohiko、Anzai Naohiko
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 150 Issue: 4 Pages: 251-258
- DOI
  10.1016/j.jphs.2022.10.002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K19348, KAKENHI-PROJECT-22K19404, KAKENHI-PROJECT-20H03813, KAKENHI-PROJECT-20K09555, KAKENHI-PROJECT-23K24071
[Journal Article] Phosphoproteomics revealed cellular signals immediately responding to disruption of cancer amino acid homeostasis induced by inhibition of l-type amino acid transporter 12022
- Author(s)
  Okanishi Hiroki、Ohgaki Ryuichi、Xu Minhui、Endou Hitoshi、Kanai Yoshikatsu
- Journal Title
  
  Cancer & Metabolism
  
  Volume: 10 Issue: 1 Pages: 18-18
- DOI
  10.1186/s40170-022-00295-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06856, KAKENHI-PROJECT-22K19404, KAKENHI-PROJECT-21K20742, KAKENHI-PROJECT-23K24071
[Journal Article] Pharmacologic inhibition of LAT1 predominantly suppresses transport of large neutral amino acids and downregulates global translation in cancer cells2022
- Author(s)
  Nishikubo Kou、Ohgaki Ryuichi、Okanishi Hiroki、Okuda Suguru、Xu Minhui、Endou Hitoshi、Kanai Yoshikatsu
- Journal Title
  
  Journal of Cellular and Molecular Medicine
  
  Volume: 26 Issue: 20 Pages: 5246-5256
- DOI
  10.1111/jcmm.17553
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06856, KAKENHI-PROJECT-22K19404, KAKENHI-PROJECT-21K20742, KAKENHI-PROJECT-22KJ2171, KAKENHI-PROJECT-20K07327, KAKENHI-PROJECT-23K24071
[Journal Article] Structural insights into inhibitory mechanism of human excitatory amino acid transporter EAAT22022
- Author(s)
  Kato Takafumi、Kusakizako Tsukasa、Jin Chunhuan、Zhou Xinyu、Ohgaki Ryuichi、Quan LiLi、Xu Minhui、Okuda Suguru、Kobayashi Kan、Yamashita Keitaro、Nishizawa Tomohiro、Kanai Yoshikatsu、Nureki Osamu
- Journal Title
  
  Nature Communications
  
  Volume: 13 Issue: 1 Pages: 4714-4714
- DOI
  10.1038/s41467-022-32442-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19404, KAKENHI-PROJECT-22K15072, KAKENHI-PROJECT-21K20742, KAKENHI-PROJECT-20H03216, KAKENHI-PROJECT-20K07327, KAKENHI-PROJECT-20K15754, KAKENHI-PROJECT-21H05037, KAKENHI-PROJECT-23K24071
[Journal Article] Functional analysis of LAT3 in prostate cancer: Its downstream target and relationship with androgen receptor2021
- Author(s)
  Rii Junryo、Sakamoto Shinichi、Sugiura Masahiro、Kanesaka Manato、Fujimoto Ayumu、Yamada Yasutaka、Maimaiti Maihulan、Ando Keisuke、Wakai Ken、Xu Minhui、Imamura Yusuke、Shindo Norihisa、Hirota Toru、Kaneda Atsushi、Kanai Yoshikatsu、Ikehara Yuzuru、Anzai Naohiko、Ichikawa Tomohiko
- Journal Title
  
  Cancer Science
  
  Volume: 112 Issue: 9 Pages: 3871-3883
- DOI
  10.1111/cas.14991
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07677, KAKENHI-PROJECT-19K07682, KAKENHI-PROJECT-20K21625, KAKENHI-PROJECT-19H05650, KAKENHI-PROJECT-18H04034, KAKENHI-PROJECT-19H03407, KAKENHI-PROJECT-20H03813, KAKENHI-PROJECT-21H03065, KAKENHI-PROJECT-20K09555, KAKENHI-PROJECT-20K18133, KAKENHI-PROJECT-21K20742
[Journal Article] The heavy chain of 4F2 antigen promote prostate cancer progression via SKP-22021
- Author(s)
  Maimaiti Maihulan、Sakamoto Shinichi、Sugiura Masahiro、Kanesaka Manato、Fujimoto Ayumi、Matsusaka Keisuke、Xu Minhui、Ando Keisuke、Saito Shinpei、Wakai Ken、Imamura Yusuke、Nakayama Keiichi、Kanai Yoshikatsu、Kaneda Atsushi、Ikehara Yuzuru、Ikeda Jun-Ichiro、Anzai Naohiko、Ichikawa Tomohiko
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 11478-11478
- DOI
  10.1038/s41598-021-90748-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07457, KAKENHI-PROJECT-19K07682, KAKENHI-PROJECT-18H05215, KAKENHI-PROJECT-19H05650, KAKENHI-PROJECT-19H03407, KAKENHI-PROJECT-20H03813, KAKENHI-PROJECT-20K09555, KAKENHI-PROJECT-20K09572, KAKENHI-PROJECT-21K06881, KAKENHI-PROJECT-20K18133, KAKENHI-PROJECT-21K20742
[Presentation] がん細胞におけるアミノ酸トランスポーター LAT1 の阻害は p38 MAPK 活性化を介したサイクリン D1 の下方制御により G0/G1 期から S 期への移行を抑制する2024
- Author(s)
  Zhou Xinyu、大垣隆一、Jin Chunhuan、Xu Minhui、岡西広樹、遠藤仁、金井好克
- Organizer
  第144回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-23K24071
[Presentation] がん細胞におけるアミノ酸トランスポーター LAT1 の阻害は p38 MAPK 活性化を介したサイクリン D1 の下方制御により G0/G1 期から S 期への移行を抑制する2024
- Author(s)
  Zhou Xinyu、大垣隆一、Jin Chunhuan、Xu Minhui、岡西広樹、遠藤仁、金井好克
- Organizer
  第144回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-22K19404
[Presentation] 個々のアミノ酸の細胞内濃度の経時変化と機能に着目したLAT1阻害薬のがん細胞増殖抑制のメカニズムの解明2023
- Author(s)
  西窪航、大垣隆一、岡西広樹、徐旻恵;、遠藤仁、金井好克
- Organizer
  第97回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-23K24071
[Presentation] 去勢抵抗性前立腺癌におけるアミノ酸トランスポーターLAT1選択的阻害薬JPH203を用いた抗腫瘍効果の検討2023
- Author(s)
  齋藤心平, 坂本信一, 安藤敬佑, 裴祥存, 柴田裕貴, 金坂学斗, 竹内信善, 佐塚智和, 今村有佑, Xu Minhui, 金井好克, 安西尚彦, 市川智彦
- Organizer
  第110回日本泌尿器科学会総会
- Data Source
  KAKENHI-PROJECT-22K19404
[Presentation] 内在性モノカルボン酸トランスポーター MCT1 との機能共役はHEK293 細胞において発現させた有機アニオントランスポーター OAT10 の輸送機能に影響する2023
- Author(s)
  大津尚子、大垣隆一、金春奐、徐旻恵、岡西広樹、髙橋亮、松井明子、佐藤正延、岸本航、石黒直樹、金井好克
- Organizer
  第97回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-23K24071
[Presentation] 去勢抵抗性前立腺癌におけるアミノ酸トランスポーターLAT1選択的阻害薬JPH203を用いた抗腫瘍効果の検討2023
- Author(s)
  齋藤心平, 坂本信一, 安藤敬佑, 裴祥存, 柴田裕貴, 金坂学斗, 竹内信善, 佐塚智和, 今村有佑, Xu Minhui, 金井好克, 安西尚彦, 市川智彦
- Organizer
  第110回日本泌尿器科学会総会
- Data Source
  KAKENHI-PROJECT-23K24071
[Presentation] 膵臓がん及び胆管がん細胞に対するアミノ酸トランスポーターLAT1阻害薬nanvuranlatと細胞障害性抗がん薬の併用効果の検討2023
- Author(s)
  西窪航、大垣隆一、劉星明、岡西広樹、徐旻恵;、遠藤仁、金井好克
- Organizer
  第143回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-23K24071
[Presentation] 内在性モノカルボン酸トランスポーター MCT1 との機能共役はHEK293 細胞において発現させた有機アニオントランスポーター OAT10 の輸送機能に影響する2023
- Author(s)
  大津尚子、大垣隆一、金春奐、徐旻恵、岡西広樹、髙橋亮、松井明子、佐藤正延、岸本航、石黒直樹、金井好克
- Organizer
  第97回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-22K19404
[Presentation] アミノ酸トランスポーターLAT1阻害薬のT細胞活性化によるPD-1阻害薬抗腫瘍効果の増進2023
- Author(s)
  徐旻恵, 周新宇, 金春奐, 岡西広樹, 大垣隆一, 遠藤仁, 金井好克
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-22K19404
[Presentation] 低酸素誘導因子の蓄積が大腸がん細胞におけるアミノ酸トランスポーターLAT1の発現に与える影響2023
- Author(s)
  大垣隆一、平瀬悠真、岡西広樹、徐旻恵、金井好克
- Organizer
  第97回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-22K19404
[Presentation] 膵臓がん及び胆管がん細胞に対するアミノ酸トランスポーターLAT1阻害薬nanvuranlatと細胞障害性抗がん薬の併用効果の検討2023
- Author(s)
  西窪航、大垣隆一、劉星明、岡西広樹、徐旻恵、遠藤仁、金井好克
- Organizer
  第143回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-22K19404
[Presentation] 個々のアミノ酸の細胞内濃度の経時変化と機能に着目したLAT1阻害薬のがん細胞増殖抑制のメカニズムの解明2023
- Author(s)
  西窪航、大垣隆一、岡西広樹、徐旻恵、遠藤仁、金井好克
- Organizer
  第97回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-22K19404
[Presentation] 低酸素誘導因子の蓄積が大腸がん細胞におけるアミノ酸トランスポーターLAT1の発現に与える影響2023
- Author(s)
  大垣隆一、平瀬悠真、岡西広樹、徐旻恵;、金井好克
- Organizer
  第97回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-23K24071
[Presentation] Enhancing Anti-tumor Effect of PD-1 Inhibitors through T-Cell Activation by Amino Acid Transporter LAT1 Inhibitor2023
- Author(s)
  Minhui Xu, Xinyu Zhou, Chunhuan Jin, Hiroki Okanishi, Ryuichi Ohgaki, Hitoshi Endou, Yoshikatsu Kanai
- Organizer
  日本癌学会総会
- Data Source
  KAKENHI-PROJECT-21K20742
[Presentation] アミノ酸トランスポーターLAT1阻害薬のT細胞活性化によるPD-1阻害薬抗腫瘍効果の増進2023
- Author(s)
  徐旻恵, 周新宇, 金春奐, 岡西広樹, 大垣隆一, 遠藤仁, 金井好克
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-23K24071
[Presentation] がん特異的アミノ酸トランスポーターLAT1阻害薬JPH203による胆道がん細胞内アミノ酸プールの破綻に伴うリン酸化プロテオーム解析2022
- Author(s)
  岡西広樹, 大垣隆一, Xu Minhui, 遠藤仁, 金井好克
- Organizer
  第142回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-22K19404
[Presentation] がん特異的アミノ酸トランスポーターLAT1 阻害薬JPH203 による胆道がん細胞内アミノ酸プールの破綻に伴うリン酸化プロテオーム解析2022
- Author(s)
  岡西広樹, 大垣隆一, Xu Minhui, 遠藤仁, 金井好克
- Organizer
  第142回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-23K24071
[Presentation] がん細胞由来エクソソーム上におけるアミノ酸トランスポーターLAT1（SLC7A5）の発現：予後および診断バイオマーカーとしての潜在的価値2022
- Author(s)
  大垣隆一, Liu Yumiao, Xu Minhui, 岡西広樹, 金井好克
- Organizer
  第96回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-22K19404
[Presentation] アミノ酸トランスポーターLAT1の阻害はがん細胞における大型中性アミノ酸輸送を顕著に低下させグローバルな翻訳抑制を誘導する2022
- Author(s)
  西窪航, 大垣隆一, 岡西広樹, 奥田傑, Xu Minhui, 遠藤仁, 金井好克
- Organizer
  第96回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-23K24071
[Presentation] アミノ酸トランスポーターLAT1阻害薬が腫瘍細胞の大型中性アミノ酸輸送とタンパク質合成に与える影響2022
- Author(s)
  西窪航, 大垣隆一, 岡西広樹, 奥田傑, Xu Minhui, 遠藤仁, 金井好克
- Organizer
  第141回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-23K24071
[Presentation] がん細胞由来エクソソーム上におけるアミノ酸トランスポーターLAT1（SLC7A5）の発現：予後および診断バイオマーカーとしての潜在的価値2022
- Author(s)
  大垣隆一, Liu Yumiao, Xu Minhui, 岡西広樹, 金井好克
- Organizer
  第96回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-23K24071
[Presentation] がん細胞由来エクソソーム上におけるアミノ酸トランスポーターLAT1（SLC7A5）の発現：予後および診断バイオマーカーとしての潜在的価値2022
- Author(s)
  大垣隆一, Liu Yumiao, 徐旻惠, 岡西広樹, 金井好克
- Organizer
  日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-21K20742
[Presentation] アミノ酸トランスポーターLAT1の阻害はがん細胞における大型中性アミノ酸輸送を顕著に低下させグローバルな翻訳抑制を誘導する2022
- Author(s)
  西窪航, 大垣隆一, 岡西広樹, 奥田傑, Xu Minhui, 遠藤仁, 金井好克
- Organizer
  第96回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-22K19404
[Presentation] がん特異的アミノ酸トランスポーターLAT1阻害薬JPH203による胆道がん細胞内アミノ酸プールの破綻に伴うリン酸化プロテオーム解析2022
- Author(s)
  岡西広樹, 大垣隆一, Xu Minhui, 遠藤仁, 金井好克
- Organizer
  日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-21K20742
[Presentation] アミノ酸トランスポーターLAT1阻害薬が腫瘍細胞の大型中性アミノ酸輸送とタンパク質合成に与える影響2022
- Author(s)
  西窪航, 大垣隆一, 岡西広樹, 奥田傑, Xu Minhui, 遠藤仁, 金井好克
- Organizer
  第141回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-22K19404
[Presentation] がん細胞におけるLAT1のアミノ酸の取込みへの寄与とLAT1阻害薬によるタンパク質合成抑制効果2022
- Author(s)
  西窪航, 大垣隆一, 岡西広樹, 奥田傑, 徐旻惠, 遠藤仁, 金井好克
- Organizer
  日本薬理学会年会要旨集
- Data Source
  KAKENHI-PROJECT-21K20742

1. Kanai Yoshikatsu (60204533)

# of Collaborated Projects: 2 results

# of Collaborated Products: 28 results
2. 大垣隆一 (20467525)

# of Collaborated Projects: 2 results

# of Collaborated Products: 31 results
3. 岡西広樹 (70792589)

# of Collaborated Projects: 2 results

# of Collaborated Products: 24 results
4. MATSUSAKA Keisuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 安西尚彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
6. 金春奐

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
7. 進藤軌久

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

XU Minhui 徐 旻恵

XU MINHUI 徐 旻恵

Research Projects

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Co-Researchers

Mechanistic analysis of potent cell cycle control and dormancy induction by amino acid transporter inhibitors in cancer cells

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去勢抵抗性前立腺がんのLAT1阻害による免疫チェックポイント阻害薬作用増強の検討Principal Investigator

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Elucidation of the transmembrane signal mechanism responsible for metabolic control by amino acid availability

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Enhancing Anti-tumor Effect of PD-1 Inhibitors through T-Cell Activation by Amino Acid Transporter LAT1 InhibitorPrincipal Investigator

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[Journal Article] Pharmacological and structural insights into nanvuranlat, a selective LAT1 (SLC7A5) inhibitor, and its N-acetyl metabolite with implications for cancer therapy2025

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[Journal Article] Structural basis of anticancer drug recognition and amino acid transport by LAT12025

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[Journal Article] L‐type amino acid transporter 1 inhibitor <scp>JPH203</scp> prevents the growth of cabazitaxel‐resistant prostate cancer by inhibiting cyclin‐dependent kinase activity2024

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[Journal Article] Identification of tumor-suppressive miRNAs that target amino acid transporter LAT1 and exhibit anti-proliferative effects on cholangiocarcinoma cells2024

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[Journal Article] Structure activity characteristics of phenylalanine analogs selectively transported by L-type amino acid transporter 1 (LAT1)2024

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[Journal Article] Amino acid transporter LAT1 is expressed on cancer cell-derived exosomes with potential as a diagnostic and prognostic biomarker2024

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[Journal Article] LAT1 expression in colorectal cancer cells is unresponsive to HIF-1/2α accumulation under experimental hypoxia2024

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[Journal Article] Upregulation of ATF4 mediates the cellular adaptation to pharmacologic inhibition of amino acid transporter LAT1 in pancreatic ductal adenocarcinoma cells2024

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[Journal Article] The <scp>LAT1</scp> inhibitor <scp>JPH203</scp> suppresses the growth of castration‐resistant prostate cancer through a <scp>CD24</scp>‐mediated mechanism2024

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[Journal Article] Inhibition of amino acid transporter LAT1 in cancer cells suppresses G0/G1-S transition by downregulating cyclin D1 via p38 MAPK activation2024

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[Journal Article] Combination effects of amino acid transporter LAT1 inhibitor nanvuranlat and cytotoxic anticancer drug gemcitabine on pancreatic and biliary tract cancer cells2023

XU Minhui 徐旻恵

XU MINHUI 徐旻恵