Sakurai Maria 櫻井まりあ

Researcher Number	20986385
Affiliation (Current)	2026: 東京大学, 大学院医学系研究科(医学部), 特任研究員
Affiliation (based on the past Project Information) *help	2023 – 2024: 東京大学, 大学院医学系研究科(医学部), 特任研究員
Review Section/Research Field	Principal Investigator Basic Section 51030:Pathophysiologic neuroscience-related / 0704:Neuroscience, brain sciences, and related fields
Keywords	Principal Investigator αシヌクレイン / 分泌小胞 / パーキンソン病 / エクソソーム / リソソーム / LRRK2 / 細胞外小胞

パーキンソン病病態に関わるLRRK2依存性リソソーム分泌機構の解析Principal Investigator
- Principal Investigator
  
  櫻井まりあ
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  The University of Tokyo
The analysis of the mechanism of LRRK2-dependent lysosomal release and its effect on a-synuclein secretionPrincipal Investigator
- Principal Investigator
  
  Sakurai Maria
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0704:Neuroscience, brain sciences, and related fields
- Research Institution
  The University of Tokyo

All 2025 2024 2023

All Journal Article Presentation

[Journal Article] Canonical and noncanonical autophagy: involvement in Parkinson’s disease2025
- Author(s)
  Sakurai Maria、Kuwahara Tomoki
- Journal Title
  
  Frontiers in Cell and Developmental Biology
  
  Volume: 13 Pages: 1518991-1518991
- DOI
  10.3389/fcell.2025.1518991
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K24210, KAKENHI-PROJECT-23K19397, KAKENHI-PROJECT-23K18253, KAKENHI-PROJECT-24K18616
[Journal Article] The V-ATPase-ATG16L1 axis recruits LRRK2 to facilitate the lysosomal stress response2024
- Author(s)
  Eguchi Tomoya、Sakurai Maria、Wang Yingxue、Saito Chieko、Yoshii Gen、Wileman Thomas、Mizushima Noboru、Kuwahara Tomoki、Iwatsubo Takeshi
- Journal Title
  
  Journal of Cell Biology
  
  Volume: 223 Issue: 3
- DOI
  10.1083/jcb.202302067
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K18253, KAKENHI-PROJECT-22K15057, KAKENHI-PROJECT-23K19397, KAKENHI-PUBLICLY-22H04638, KAKENHI-PROJECT-22H04919, KAKENHI-PROJECT-23K24210
[Journal Article] Lysosomal stress drives the release of pathogenic α-synuclein from macrophage lineage cells via the LRRK2-Rab10 pathway2024
- Author(s)
  Abe Tetsuro、Kuwahara Tomoki、Suenaga Shoichi、Sakurai Maria、Takatori Sho、Iwatsubo Takeshi
- Journal Title
  
  iScience
  
  Volume: 27 Issue: 2 Pages: 108893-108893
- DOI
  10.1016/j.isci.2024.108893
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K18253, KAKENHI-PROJECT-23K19397, KAKENHI-PUBLICLY-22H04638, KAKENHI-PROJECT-23K24210
[Journal Article] Phosphorylation of Rab29 at Ser185 regulates its localization and role in the lysosomal stress response in concert with LRRK22023
- Author(s)
  Komori Tadayuki、Kuwahara Tomoki、Fujimoto Tetta、Sakurai Maria、Koyama-Honda Ikuko、Fukuda Mitsunori、Iwatsubo Takeshi
- Journal Title
  
  Journal of Cell Science
  
  Volume: 136 Issue: 14
- DOI
  10.1242/jcs.261003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K19397, KAKENHI-PUBLICLY-22H04638, KAKENHI-PROJECT-23K24210
[Presentation] The molecular mechanism of LRRK2-regulated exosome secretion under lysosomal stress2024
- Author(s)
  Maria Sakurai, Tomoki Kuwahara, Takeshi Iwatsubo
- Organizer
  Biennial International LRRK2 meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24K18616
[Presentation] The molecular mechanism of LRRK2-mediated release of extracellular vesicles under lysosomal stress2024
- Author(s)
  Maria Sakurai, Tomoki Kuwahara, Takeshi Iwatsubo
- Organizer
  第97回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-24K18616
[Presentation] The molecular mechanism of LRRK2-mediated release of extracellular vesicles under lysosomal stress2024
- Author(s)
  Maria Sakurai, Tomoki Kuwahara, Takeshi Iwatsubo
- Organizer
  第97回生化学会大会
- Data Source
  KAKENHI-PROJECT-23K19397
[Presentation] The molecular mechanism of LRRK2-regulated exosome secretion under lysosomal stress2024
- Author(s)
  Maria Sakurai, Tomoki Kuwahara, Takeshi Iwatsubo
- Organizer
  Biennial International LRRK2 Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K19397
[Presentation] Analysis of the novel extracellular release pathway of lysosomal contents mediated by Parkinson’s disease kinase LRRK22023
- Author(s)
  櫻井まりあ、桑原知樹、江口智也、岩坪威
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-23K19397
[Presentation] パーキンソン病病因キナーゼLRRK2が制御するリソソーム内容物分泌機構の解析2023
- Author(s)
  櫻井まりあ、桑原知樹、江口智也、岩坪威
- Organizer
  第15回オートファジー研究会
- Data Source
  KAKENHI-PROJECT-23K19397
[Presentation] パーキンソン病病因遺伝子産物LRRK2が制御するリソソーム分泌機構の解明2023
- Author(s)
  櫻井まりあ、桑原知樹、今村理世、小島宏達、岩坪威
- Organizer
  第14回スクリーニング学研究会
- Data Source
  KAKENHI-PROJECT-23K19397

1. KUWAHARA Tomoki

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results

Sakurai Maria 櫻井 まりあ

Research Projects

Research Products

Co-Researchers

パーキンソン病病態に関わるLRRK2依存性リソソーム分泌機構の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The analysis of the mechanism of LRRK2-dependent lysosomal release and its effect on a-synuclein secretionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Canonical and noncanonical autophagy: involvement in Parkinson’s disease2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The V-ATPase-ATG16L1 axis recruits LRRK2 to facilitate the lysosomal stress response2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Lysosomal stress drives the release of pathogenic α-synuclein from macrophage lineage cells via the LRRK2-Rab10 pathway2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Phosphorylation of Rab29 at Ser185 regulates its localization and role in the lysosomal stress response in concert with LRRK22023

Author(s)

Journal Title

DOI

Data Source

[Presentation] The molecular mechanism of LRRK2-regulated exosome secretion under lysosomal stress2024

Author(s)

Organizer

Data Source

[Presentation] The molecular mechanism of LRRK2-mediated release of extracellular vesicles under lysosomal stress2024

Author(s)

Organizer

Data Source

[Presentation] The molecular mechanism of LRRK2-mediated release of extracellular vesicles under lysosomal stress2024

Author(s)

Organizer

Data Source

[Presentation] The molecular mechanism of LRRK2-regulated exosome secretion under lysosomal stress2024

Author(s)

Organizer

Data Source

[Presentation] Analysis of the novel extracellular release pathway of lysosomal contents mediated by Parkinson’s disease kinase LRRK22023

Author(s)

Organizer

Data Source

[Presentation] パーキンソン病病因キナーゼLRRK2が制御するリソソーム内容物分泌機構の解析2023

Author(s)

Organizer

Data Source

[Presentation] パーキンソン病病因遺伝子産物LRRK2が制御するリソソーム分泌機構の解明2023

Author(s)

Organizer

Data Source

Sakurai Maria 櫻井まりあ