KUMAZAWA Yoshio 熊沢義雄

Researcher Number	30072375
Other IDs
Affiliation (based on the past Project Information) *help	2010: いわき星大学, 薬学部, 客員研究員 2008 – 2010: Iwaki Meisei University, 薬学部, 客員研究員 1999 – 2007: 北里大学, 理学部, 教授 1994 – 1996: Kitasato Univ., School of Sci., Professor, 理学部, 教授 1993: 北里大学, 薬学部, 講師
Review Section/Research Field	Principal Investigator Bacteriology (including Mycology) / Bacteriology (including Mycology) / Biological pharmacy Except Principal Investigator Bacteriology (including Mycology) / Bacteriology (including Mycology)
Keywords	Principal Investigator IFN-γ / IL-12 / サイトカイン / IL-4 / LPS / 結核菌糖脂質 / マクロファージ / IL-10 / モルモット / mycobacterial glycolipid … More / 単クローン抗体 / CD1 / NF-κB / Toll-like receptor / macrophage / S.typhimurium / Th1 & Th2 / IFNgamma / IFNγ / RT-PCR / monoclonal antibodies / Cytokines / Guinea pig / CD1b / monoclonal antibody / cytokine / guinea pigs / LIPID RAFT / MACROPHAGE / BACTERIAL GLYCOLIPID / TOLL-LIKE RFCEPTOR / NF-kB / 脂質ラフト / 結核菌由来糖脂質 / TLR / INNATE IMMUNITY / CELL WALL COMPONENTS / LIPOPOLYSACCHARIDE / TOLL-LIKE RECEPTOR / 先天性免疫 / 細菌構成成分 / リポ多糖 / NK1+T cells / TNFalpha / フローサイトメトリー / サルモネラ感染 / NKT細胞 / 内毒素(LPS) / NK1^+T cells / TNFα / IFN_γ / Macrophage / Cytokine / Anti-CD3 (epsilon) mAb / 抗原提示細胞 / 抗TcRalphabeta抗体 / 細菌性スーパー抗原(SEA) / IFN-gamma / 細菌内毒素(LPS) / T細胞レセプター(TcR) / ヘルパーT細胞(Th1とTh2) / IFNα / 抗CD3抗体 / 感染免疫 … More Except Principal Investigator HMGB-1 / ENDOTOXIN SHOCK / エンドトキシンショック / HMG-1 / HESPERIDIN / NARINGIN / FLAVONOIDS / GALACTOSAMINE CHALLENGED MICE / S. typhimurium INFECTION / ガラクトサミン負荷マウス / ヘスペリジン / ナリンジン / フラボノイド / D-ガラクトサミン負荷マウス / S.typhimurium感染 / APOPTOSIS / GALACTOSAMINE-SENSITIZED MODEL / ネズミチフス菌感染 / アポトーシス / ガラクトサミン感作モデル / TLR2 / IL-17 / γδ型T細胞 / 肉芽腫 / 結核菌糖脂質 / 感染免疫 Less

Antigen presentation and cytokine resposes against mycobial glycolipids.Principal Investigator
- Principal Investigator
  
  KUMAZAWA Yoshio
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Iwaki Meisei University
Mechanism of granuloma formation by mycobacterial glycolipi ds
- Principal Investigator
  
  TAKIMOTO Hiroaki
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Kitasato University
IMMUNE RESPONSE TO GLYCOLIPIDS SEPARETED FROM MYCOBACTERIUM TUBERCULOSISPrincipal Investigator
- Principal Investigator
  
  KUMAZAWA Yoshio
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Kitasato University
IMMUNE RESPONSE TO GLYCOLIPIDS SEPARETED FROM MYCOBACTERIUM TUBERCULOSIS IN GUINEA PIGPrincipal Investigator
- Principal Investigator
  
  KUMAZAWA Yoshio
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  KITASATO UNIVERSITY
THE ROLE OF HMGB-1 AS CYTOKINE IN INFECTION
- Principal Investigator
  
  HASUNUMA Ryoichi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Kitasato University
MOLECULAR MECHANISMS OF CROSSTALK BETWEEN MYCOBACTERIAL GLYCOLIPIDS AND RECEPTORS ON MACROPHAGESPrincipal Investigator
- Principal Investigator
  
  KUMAZAWA Yoshio
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  KITASATO UNIVERSITY
ACTION MECHANISMS OF HMG-1 ON ENDOTOXIN SHOCK
- Principal Investigator
  
  HASUNUMA Ryoichi
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  KITASATO UNIVERSITY
ROLE OF TOLL-LIKE RECEPTOR-2 IN INNATE IMMUNITYPrincipal Investigator
- Principal Investigator
  
  KUMAZAWA Yoshio
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  KITASATO UNIVERSITY
SALMONELLA INFECTION AND CYTOKINES-ANALYSIS USING KNOCK-OUT MICEPrincipal Investigator
- Principal Investigator
  
  KUMAZAWA Yoshio
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  KITASATO UNIVERSITY
Mechanisms of helper T cell response controlling by cytokinesPrincipal Investigator
- Principal Investigator
  
  KUMAZAWA Yoshio
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Kitasato University, School of Science

All 2011 2010 2009 2008 2007 2006 2004 Other

All Journal Article Presentation

[Journal Article] Natural Antioxidants and their Derivatives : Biology and Clinical Application.2011
- Author(s)
  Magrone T, Kumazawa Y, Jirillo E.
- Journal Title
  
  Curr Top Med Chem. in press
- Data Source
  KAKENHI-PROJECT-20590453
[Journal Article] Effects of Antioxidant Polyphenols on TNF-alpha-Related Diseases.2011
- Author(s)
  Kawaguchi K, Matsumoto T, Kumazawa Y.
- Journal Title
  
  Curr Top Med Chem. in press
- Data Source
  KAKENHI-PROJECT-20590453
[Journal Article] Suppression of inflammatory responses after onset of collagen-induced arthritis in mice by oral administration of the Citrus flavanone naringin.2011
- Author(s)
  Kawaguchi K, Maruyama H, Hasunuma R, Kumazawa Y.
- Journal Title
  
  Immunopharmacol Immunotoxicol. in press
- Data Source
  KAKENHI-PROJECT-20590453
[Journal Article] Suppression of type-I allergic responses by oral administration of grape marc fermented with Lactobacillus plantarum.2010
- Author(s)
  Tominaga T, Kawaguchi K, Kanesaka M, Kawauchi H, Jirillo E, Kumazawa Y.
- Journal Title
  
  Immunopharmacol Immunotoxicol. 32(4)
  
  Pages: 593-599
- Data Source
  KAKENHI-PROJECT-20590453
[Journal Article] Inhibitory effects of fermented grape marc from Vitis vinifera Negroamaro on antigen-induced degranulation.2010
- Author(s)
  Kaneko M, Kanesaka M, Yoneyama M, Tominaga T, Jirillo E, Kumazawa Y.
- Journal Title
  
  Immunopharmacol Immunotoxicol. PubMed PMID : 20100066 32(3)
  
  Pages: 454-461
- Data Source
  KAKENHI-PROJECT-20590453
[Journal Article] Potentiation of murine innate immunity by α-galacturonosyl-type glycosphingolipids isolated from Sphingomonas yanoikuyae and S. terrae.2009
- Author(s)
  Kubota, M., H. Takimoto, M. Kaneko, J. Inoue, Y. Kumazawa
- Journal Title
  
  Immunopharmacol Immunotoxicol 31
  
  Pages: 363-369
- Data Source
  KAKENHI-PROJECT-20590454
[Journal Article] Potentiation of murine innate immunity by alpha-galacturonosyl-type glycosphingolipids isolated from Sphingomonas yanoikuyae and S. terrae.2009
- Author(s)
  Kubota M, Takimoto H, Kaneko M, Inoue J, Kumazawa Y.
- Journal Title
  
  Immunopharmacol Immunotoxicol. 31(3)
  
  Pages: 363-369
- Data Source
  KAKENHI-PROJECT-20590453
[Journal Article] Liposomal glycosphingolipids activate natural killer T cell-mediated immune responses through the endosomal pathway.2009
- Author(s)
  Inoue J, Ideue R, Takahashi D, Kubota M, Kumazawa Y.
- Journal Title
  
  J Control Release. 133(1)
  
  Pages: 18-23
- Data Source
  KAKENHI-PROJECT-20590453
[Journal Article] Suppressive effects of the flavonoids quercetin and luteolin on the accumulation of lipid rafts after signal transduction via receptors.2008
- Author(s)
  Kaneko M, Takimoto H, Sugiyama T, Seki Y, Kawaguchi K, Kumazawa Y.
- Journal Title
  
  Immunopharmacol Immunotoxicol. 30(4)
  
  Pages: 867-882
- Data Source
  KAKENHI-PROJECT-20590453
[Journal Article] Suppressive effects of flavonoids quercetin and luteolin on lipid raft accumulation following signal transduction via receptors.2008
- Author(s)
  Kaneko, M., H. Takimoto, Y. Seki, K. Kawaguchi, Y. Kumazawa
- Journal Title
  
  Immunopharmacol Immunotoxicol 30
  
  Pages: 867-882
- Data Source
  KAKENHI-PROJECT-20590454
[Journal Article] Amelioration of skewed Th1/Th2 balance in tumor-bearing and asthma-induced mice by oral administration of Agaricus blazei extracts.2008
- Author(s)
  Takimoto H, Kato H, Kaneko M, Kumazawa Y.
- Journal Title
  
  Immunopharmacol Immunotoxicol. 30(4)
  
  Pages: 747-760
- Data Source
  KAKENHI-PROJECT-20590453
[Journal Article] Amelioration of skewed Th1/Th2 balance in tumor-bearing and asthma-induced mice by oral administration of Agaricus blazei extracts.2008
- Author(s)
  Takimoto, H., H. Kato, M. Kaneko, Y. Kumazawa
- Journal Title
  
  Immunopharmacol Immunotoxicol 30
  
  Pages: 747-760
- Data Source
  KAKENHI-PROJECT-20590454
[Journal Article] Effects of isoflavones and soybeans fermented with Bacillus subtilis on lipopolysaccharide-induced production of tumor necrosis factor α and fibrinolysis in vivo.2007
- Author(s)
  Hasunuma R, Kawaguchi K, Kikuchi S, Sugiyama T, Kumazawa Y
- Journal Title
  
  Immunopharm Immunotox 29
  
  Pages: 323-333
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590436
[Journal Article] Immunomodulating effects of flavonoids on acute and chronic inflammatory responses caused by tumor necrosis factor α2006
- Author(s)
  Kumazawa Y.
- Journal Title
  
  Cur.Pharm.Design 12
  
  Pages: 4271-4279
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590436
[Journal Article] Immunomodulating effects of flavonoids on acute and chronic inflammatory responses caused by tumor necrosis factor α2006
- Author(s)
  Kumazawa, Y
- Journal Title
  
  Cur. Pharm. Design 12(32)
  
  Pages: 4271-4279
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590436
[Journal Article] Limitation of polymyxin B on suppression of endotoxin shock induced by Salmonella infection in mice.2004
- Author(s)
  Morita, H., R.Hasunuma, K.Kawaguchi, Y.Adachi, S.Tanaka, Y.Kumazawa
- Journal Title
  
  Biol.Pharm.Bull. 27(11)
  
  Pages: 1840-1843
- NAID
  110003608708
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590397
[Journal Article] A Citrus flavonoid hesperidin suppresses infection-induced endotoxin shock in mice.2004
- Author(s)
  Kawaguchi, K., S.Kikuchi, R.Hasunuma, H.Maruyama, T.Yoshikawa, Y.Kumazawa
- Journal Title
  
  Biol.Pharm.Bull. 27(5)
  
  Pages: 679-683
- NAID
  110003608830
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590397
[Journal Article] Suppression of infection-induced endotoxin shock in mice by a Citrus flavanone naringin.2004
- Author(s)
  Kawaguchi, K., S.Kikuchi, R.Hasunuma, H.Maruyama, R.Ryll, Y.Kumazawa
- Journal Title
  
  Planta Med. 70(1)
  
  Pages: 17-22
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590397
[Journal Article] Suppressive effects of flavonoids quercetin and luteolin on lipid raft accumulation following signal transduction via receptors.
- Author(s)
  Kaneko M, Takimoto H, Seki Y, Kawaguchi K, Kumazawa Y
- Journal Title
  
  Immunopharm Immunotox (掲載確定)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590436
[Journal Article] Quercetin but not luteolin suppresses the induction of lethal shock upon infection of mice with Salmonella typhimurium.
- Author(s)
  Sugiyama T, Kawaguchi K, Dobashi H, Miyake R, Kaneko M, Kumazawa Y.
- Journal Title
  
  FEMS Immunol Microbiol (掲載確定)(in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590436
[Presentation] 結核菌糖脂質trehalose 6, 6'-dimicolate (TDM)による肉芽腫形成におけるγδ型T細胞の役割2010
- Author(s)
  齋藤昂良、滝本博明、矢野郁也、熊沢義雄、服部雅一
- Organizer
  第83回日本細菌学会総会 [日本細菌学雑誌第65巻(1):183]
- Place of Presentation
  横浜
- Year and Date
  2010-03-29
- Data Source
  KAKENHI-PROJECT-20590453
[Presentation] 結核菌糖脂質trehalose 6, 6'-dimicolate(TDM)による肉芽腫形成におけるγδ型T細胞の役割2010
- Author(s)
  齋藤昂良、滝本博明、矢野郁也、熊沢義雄、服部雅一
- Organizer
  日本細菌学会
- Place of Presentation
  パシフィコ横浜会議センター(神奈川県)
- Data Source
  KAKENHI-PROJECT-20590454
[Presentation] 結核菌糖脂質trehalose 6,6'-dimicolate(TDM)による肉芽腫形成におけるγδ型T細胞の役割2010
- Author(s)
  齋藤昂良、滝本博明、矢野郁也、熊沢義雄、服部雅一
- Organizer
  第83回日本細菌学会総会[日本細菌学雑誌第65巻(1):183]
- Place of Presentation
  横浜
- Year and Date
  2010-03-29
- Data Source
  KAKENHI-PROJECT-20590454
[Presentation] 結核菌糖脂質trehalose 6,6'-dimycolate(TDM)による炎症誘導作用2009
- Author(s)
  齋藤昴良、滝本博明、矢野郁也、熊沢義雄
- Organizer
  第82回日本細菌学会総会[日本細菌学雑誌第64巻(1):191]
- Place of Presentation
  名古屋
- Year and Date
  2009-03-13
- Data Source
  KAKENHI-PROJECT-20590454
[Presentation] 結核菌糖脂質trehalose 6, 6'-dimycolate (TDM)による炎症誘導作用2009
- Author(s)
  齋藤昴良、滝本博明、矢野郁也、熊沢義雄
- Organizer
  第82回日本細菌学会総会 [日本細菌学雑誌第64巻(1):191]
- Place of Presentation
  名古屋
- Year and Date
  2009-03-13
- Data Source
  KAKENHI-PROJECT-20590453
[Presentation] 結核菌糖脂質trehalose 6, 6'-dimicolateによる肉芽腫形成におけるIL-17産生γδ型T細胞の役割2009
- Author(s)
  齋藤昂良、滝本博明、矢野郁也、熊沢義雄
- Organizer
  第92回日本細菌学会関東支部総会 [第92回日本細菌学会関東支部総会講演抄録集p.42]
- Place of Presentation
  東京
- Year and Date
  2009-11-05
- Data Source
  KAKENHI-PROJECT-20590453
[Presentation] 結核菌糖脂質trehalose 6, 6'-dimicolateによる肉芽腫形成におけるIL-17産生γδ型T細胞の役割2009
- Author(s)
  齋藤昂良、滝本博明、矢野郁也、熊沢義雄
- Organizer
  第92回日本細菌学会関東支部総会[第92回日本細菌学会関東支部総会講演抄録集p.42]
- Place of Presentation
  東京
- Year and Date
  2009-11-05
- Data Source
  KAKENHI-PROJECT-20590454
[Presentation] 結核菌糖脂質trehalose 6,6'-dimycolate(TDM)による炎症誘導作用2008
- Author(s)
  齋藤昴良、滝本博明、矢野郁也、熊沢義雄
- Organizer
  第38回日本免疫学会総会学術集会[日本免疫学会学術集会記録第38巻:158]
- Place of Presentation
  京都
- Year and Date
  2008-12-02
- Data Source
  KAKENHI-PROJECT-20590454
[Presentation] 組換えモルモットサイトカインと単クローン抗体の作製2008
- Author(s)
  宮崎弘基、滝本博明、熊沢義雄
- Organizer
  第81回日本細菌学会総会
- Place of Presentation
  京都
- Year and Date
  2008-03-24
- Data Source
  KAKENHI-PROJECT-18590436
[Presentation] 結核菌糖脂質trehalose 6, 6'-dimycolate (TDM)による炎症誘導作用2008
- Author(s)
  齋藤昴良、滝本博明、矢野郁也、熊沢義雄
- Organizer
  第38回日本免疫学会総会学術集会 [日本免疫学会学術集会記録第38巻:158]
- Place of Presentation
  京都
- Year and Date
  2008-12-02
- Data Source
  KAKENHI-PROJECT-20590453

1. TAKIMOTO Hiroaki (00253534)

# of Collaborated Projects: 7 results

# of Collaborated Products: 17 results
2. HASUNUMA Ryoichi (30104566)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
3. HANAOKA Kazunori (40189577)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

KUMAZAWA Yoshio 熊沢 義雄

Research Projects

Research Products

Co-Researchers

Antigen presentation and cytokine resposes against mycobial glycolipids.Principal Investigator

Principal Investigator

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Mechanism of granuloma formation by mycobacterial glycolipi ds

Principal Investigator

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IMMUNE RESPONSE TO GLYCOLIPIDS SEPARETED FROM MYCOBACTERIUM TUBERCULOSISPrincipal Investigator

Principal Investigator

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IMMUNE RESPONSE TO GLYCOLIPIDS SEPARETED FROM MYCOBACTERIUM TUBERCULOSIS IN GUINEA PIGPrincipal Investigator

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THE ROLE OF HMGB-1 AS CYTOKINE IN INFECTION

Principal Investigator

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MOLECULAR MECHANISMS OF CROSSTALK BETWEEN MYCOBACTERIAL GLYCOLIPIDS AND RECEPTORS ON MACROPHAGESPrincipal Investigator

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Project Period (FY)

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Research Institution

ACTION MECHANISMS OF HMG-1 ON ENDOTOXIN SHOCK

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ROLE OF TOLL-LIKE RECEPTOR-2 IN INNATE IMMUNITYPrincipal Investigator

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Research Institution

SALMONELLA INFECTION AND CYTOKINES-ANALYSIS USING KNOCK-OUT MICEPrincipal Investigator

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Research Institution

Mechanisms of helper T cell response controlling by cytokinesPrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

[Journal Article] Natural Antioxidants and their Derivatives : Biology and Clinical Application.2011

Author(s)

Journal Title

Data Source

[Journal Article] Effects of Antioxidant Polyphenols on TNF-alpha-Related Diseases.2011

Author(s)

Journal Title

Data Source

[Journal Article] Suppression of inflammatory responses after onset of collagen-induced arthritis in mice by oral administration of the Citrus flavanone naringin.2011

Author(s)

Journal Title

Data Source

[Journal Article] Suppression of type-I allergic responses by oral administration of grape marc fermented with Lactobacillus plantarum.2010

Author(s)

Journal Title

Data Source

KUMAZAWA Yoshio 熊沢義雄