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KOBAYASHI Tetsuro  小林 哲郎

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Kobayashi Tetsuro  小林 哲郎

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Researcher Number 30113442
Affiliation (Current) 2025: (財)冲中記念成人病研究所, その他部局等, 研究員
Affiliation (based on the past Project Information) *help 2021 – 2024: (財)冲中記念成人病研究所, その他部局等, 研究員
2017: (財)冲中記念成人病研究所, その他部局等, 研究員
2014 – 2016: 公益財団法人冲中記念成人病研究所, その他部局等, 研究員
2014: 公益財団法人冲中記念成人病研究所, 研究室, 研究員
2014: 公益財団法人冲中記念成人病研究所, 研究所, 研究員 … More
2012 – 2013: 山梨大学, 医学工学総合研究部, 教授
2007 – 2011: 山梨大学, 大学院・医学工学総合研究部, 教授
2010: 山梨大学, 医学工学総合研究部, 教授
2006: University of Yamanashi, Department of research Interdisciplinary Graduate school of Mediciine and Engireering, Professor, 大学院医学工学総合研究部, 教授
2003 – 2005: 山梨大学, 大学院・医学工学総合研究部, 教授
2002: University of Yamanashi, Faculty of Medicine, Professor, 医学部, 教授
2001: 山梨医科大学, 医学部, 教授
1998: 冲中記念成人病研究所, 研究員
1997 – 1998: 財団法人冲中記念成人病研究所, 研究員
1995: Research associate Okinaka Memorial Institute for Medical Research, 研究員
1994: (財)冲中記念成人病研究所, 研究員
1993: (財)〓中記念成人病研究所, 研究員
1993: 冲中記念成人病研究所, 研究員
1991 – 1992: 財団法人冲中記念成人病研究所, 研究員
1989: 沖中記念成人病研究所, 研究員
1988: 冲中記念成人病研究所, 研究員
1987: Okinaka Memorial Institute for Medical Research, 研究所, 研究員
1986: 冲中成人病研, その他, 研究員 Less
Review Section/Research Field
Principal Investigator
内分泌・代謝学 / Metabolomics / Basic Section 54040:Metabolism and endocrinology-related / Metabolomics
Except Principal Investigator
Metabolomics / 内科学一般 / Endocrinology
Keywords
Principal Investigator
ICA / IDDM / HLA / 糖尿病 / エピトープ / GAD抗体 / 1型糖尿病 / IFNβ / MDA5 / 2Apro … More / VP1 / Enterovirus / epitope spreading / SPIDDM / epitope / 膵島細胞抗体 / I型糖尿病 / 緩徐進行1型糖尿病 / β細胞 / インスリン依存型糖尿病 / インターフェロンβ / Toll-like receptor4 / 2A protease / 膵病変 / メタプラジア / エンテロウイルス / PanIN lesion / lesion / PanIN / Metaplasia / REGⅠα / インスリン / BrdU / REGIα / EMCウイルス / 再生医学 / ウイルス / Lymphocyte / Islet cell antibodies / Type I Diabetes / 【I】型糖尿病 / リンパ球 / type 2 diabetes / type 1 diabetes / GAD antibody / glutamic acid decarboxylase (GAD) / キメラ / slowly progressive IDDM / GAD antibodies / CAD抗体 / Slowly progressive IDDM / Soluble HLA / slowlu pogressive IDDM / amyloid / beta cell / mitochondrial enzyme / diabetes mellitus / mitochondrial DNA / ミトコンドリア遺伝子異常 / アミロイド / ミトコンドリア酵素 / ミトコンドリア遺伝子 / サイトケラチン / 膵外分泌腺抗体 / ER stress / Innate immunity / Type 1 diabetes / CD28 / NODマウス / 緩徐1型糖尿病 / β-細胞 / GAD / アミラーゼ抗体 / 膵島炎 / GAD65 / 抗膵外分泌腺抗体 / 抗膵島細胞抗体 / 自己免疫 / EBウィルス / サイトメガロウィルス … More
Except Principal Investigator
糖尿病 / 自己抗体 / 劇症1型糖尿病 / 1型糖尿病 / アミラーゼ / 自己免疫性膵炎 / 劇症1型糖尿病 / ELISA / molecular biology / pancreas specific gene / differentiation / pancreatic β-cell regeneration / 分子生物学 / 膵特異的遺伝子 / 分化誘導 / 膵β細胞再生 / autoantibody / glutamic acid decarboxylase 65 / knockout mice / type 1 diabetes / NODマウス / エピトープ / GAD抗体 / 抗体 / GAD65 / ノックアウトマウス / organogenesis / β cell / pancreas / pancreatic puodenal homeobox-1 / EYFP / homeobox-1 / pancreatic duodenal / トランスジェニックマウス / β細胞 / 膵臓 / pancreatic duct / beta cell / transgenic mouse / YFP / PDX-1 / LDL receptor / HLA antigen / Blood coagulation-fibrinolysis / Lipoprotein (a) / HDL-cholesterol / Serum cholesterol values / Coronary artery sclerosis / Familial hypercholesterolemia / 家族性高コレステロ-ル血症 / LDLレセプター遺伝子変異 / Lp(a) / 冠動脈硬化 / LDLレセプター / HLA抗原 / 凝固線溶系分子マーカー / 高Lp(a)血症 / HDL-コレステロール / 血清コレステロール値 / 冠動脈硬化症 / 家族性高コレステロール血症 / 膵再生 / 小胞体ストレス / 内分泌学 / 内分泌 / ヘルペスウイルス / プロテオミクス / インターフェロンγ / インターフェロンα / ヘルペスウィルス / エンテロウィルス / エンテロウイルス / ウイルス感染 / 自然免疫 / DNA 免疫 / DNA免疫 / 慢性膵炎 / Amylaseα-2A / 2型糖尿病 / IgG4 / 劇症1型糖尿 / 糖質代謝異常 / エネルギー / [○!R]-catenin / β-catenin / TCF7L2遺伝子 / 再生医療 / 膵発生 / cDNA Less
  • Research Projects

    (21 results)
  • Research Products

    (113 results)
  • Co-Researchers

    (23 People)
  •  Detection of enterovirus infection in type 1 diabetes and pancreas cancer tic cancer.Principal Investigator

    • Principal Investigator
      小林 哲郎
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 54040:Metabolism and endocrinology-related
    • Research Institution
      Okinaka Memorial Institute for Medical Research
  •  Distinct features of the pancreas in slowly progressive insulin dependent diabetes mellitusPrincipal Investigator

    • Principal Investigator
      Kobayashi Tetsuro
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 54040:Metabolism and endocrinology-related
    • Research Institution
      Okinaka Memorial Institute for Medical Research
  •  Physiological and pathophysilogical roles of acinar-like cell cluster touching Langerhans islet with thin interstitial surrounding (ATLANTIS) on regeneration and maintenance of beta cell.Principal Investigator

    • Principal Investigator
      Kobayashi Tetsuro
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Metabolomics
    • Research Institution
      Okinaka Memorial Institute for Medical Research
  •  Development of slowly progressive type 1 diabetes animal models using the CD28 knock-out NOD mousePrincipal Investigator

    • Principal Investigator
      KOBAYASHI Tetsuro
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Metabolomics
    • Research Institution
      Okinaka Memorial Institute for Medical Research
      University of Yamanashi
  •  Pathopysiology of fuluminant type 1 diabetes and development of its new therapy

    • Principal Investigator
      ENDO Toyoshi
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Metabolomics
    • Research Institution
      University of Yamanashi
  •  The role of innate immunity in the pathogenesis of fulminant type 1 diabetes.

    • Principal Investigator
      AIDA Kaoru
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Metabolomics
    • Research Institution
      University of Yamanashi
  •  Impaired oxidative endoplasmic reticulum stress response caused by deficiency of thyroid hormone receptor

    • Principal Investigator
      FURUYA Fumihiko
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Endocrinology
    • Research Institution
      University of Yamanashi
  •  Characterization of autoantibody against Amylaseα-2A in patients with fulminant type 1 diabetes mellitus and autoimmune pancreatitis, and its clinical use.

    • Principal Investigator
      ENDO Toyoshi
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Metabolomics
    • Research Institution
      University of Yamanashi
  •  The roles of TCF7L2 gene in the development of pancreas and pathogenesis of diabetes

    • Principal Investigator
      AIDA Kaoru
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Metabolomics
    • Research Institution
      University of Yamanashi
  •  Immunological prevention of type 1 diabetes using GAD65-encording DNA vaccinePrincipal Investigator

    • Principal Investigator
      KOBAYASHI Tetsuro
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Metabolomics
    • Research Institution
      University of Yamanashi
  •  Early detection and diagnosis of fulminant type 1 diadetes mellitus

    • Principal Investigator
      ENDO Toyoshi
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Metabolomics
    • Research Institution
      University of Yamanashi
  •  Identification of genes that are involved in differentiation of pancreatic ductal cells to pancreatic β-cells.

    • Principal Investigator
      AIDA Kaoru
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Metabolomics
    • Research Institution
      University of Yamanashi
  •  Association of glutamic acid antibody with the development and/or the progression of the disease in autoimmune type 1 diabetes mellitus

    • Principal Investigator
      OMORI Masayuki
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Metabolomics
    • Research Institution
      University of Yamanashi
  •  Organogenesis of pancreas in PDX-1 promoter/YFP transgenic mouse

    • Principal Investigator
      ENDO Toyoshi
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Metabolomics
    • Research Institution
      University of Yamanashi
  •  Studies on epitopes of glutamic acid decarboxylase 65 (GAD65) antibodies in type 1 diabetesPrincipal Investigator

    • Principal Investigator
      KOBAYASHI Tetsuro
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Metabolomics
    • Research Institution
      University of Yamanashi Faculty of Medicine
  •  Study on the pathogenetic roles of pancretic antigen on the beta-cell destruction in insulin-dependent diabetes mellitusPrincipal Investigator

    • Principal Investigator
      KOBAYASHI Tetsuro
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      内分泌・代謝学
    • Research Institution
      Okinaka Memorial Institute for Medical Research
  •  Study on the pathogenetic roles of mutation of mitochondrial DNA at position 3243 on diabetes mellitusPrincipal Investigator

    • Principal Investigator
      KOBAYASHI Tetsuro
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      内分泌・代謝学
    • Research Institution
      Okinaka Memorial institute for Medical Research
  •  Studies on the susceptibility to coronary artery sclerosis in patients with familial hypercholesterolemia

    • Principal Investigator
      MURASE Toshio
    • Project Period (FY)
      1991 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      内科学一般
    • Research Institution
      Okinaka Memorial Institute for Medical Research
  •  インスリン依存型糖尿病患者における膵組織中VirusDNAの検出Principal Investigator

    • Principal Investigator
      小林 哲郎
    • Project Period (FY)
      1989
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      内分泌・代謝学
    • Research Institution
      Okinaka Memorial Institute for Medical Research
  •  I型糖尿病における膵外分泌腺細胞抗体の免疫化学的性状に関する研究Principal Investigator

    • Principal Investigator
      小林 哲郎
    • Project Period (FY)
      1988
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      内分泌・代謝学
    • Research Institution
      Okinaka Memorial Institute for Medical Research
  •  Study on the Islet Cell Antibodies(ICA)and ICA-producing Lymphocytes in Type I Diabetes MellitusPrincipal Investigator

    • Principal Investigator
      KOBAYASHI Tetsuro
    • Project Period (FY)
      1986 – 1987
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      内分泌・代謝学
    • Research Institution
      Okinaka Memorial Institute for Medical Research

All 2024 2023 2022 2021 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 Other

All Journal Article Presentation Book

  • [Book] 内分泌・糖尿病・代謝内科2017

    • Author(s)
      小林哲郎
    • Total Pages
      7
    • Publisher
      科学評論社
    • ISBN
    • Data Source
      KAKENHI-PROJECT-15K09406
  • [Book] 糖尿病研修ノート2010

    • Author(s)
      小林哲郎
    • Total Pages
      628
    • Publisher
      診断と治療社
    • Data Source
      KAKENHI-PROJECT-20591056
  • [Book] 内科臨床雑誌(特集)糖尿病マネージメントup-to-date新しいインスリン製剤2008

    • Author(s)
      小林哲郎
    • Total Pages
      200
    • Publisher
      南江堂
    • Data Source
      KAKENHI-PROJECT-20591056
  • [Journal Article] Slowly progressive insulin-dependent diabetes mellitus in type 1 diabetes endotype 2.2024

    • Author(s)
      Kobayashi T, Kadowaki T.
    • Journal Title

      Nat Rev Endocrinol

      Volume: 20 Issue: 5 Pages: 312-312

    • DOI

      10.1038/s41574-024-00975-z

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K08541
  • [Journal Article] Bi-glandular and persistent enterovirus infection and distinct changes of the pancreas in slowly progressive type 1 diabetes mellitus2023

    • Author(s)
      Fukui Tomoyasu、Kobayashi Tetsuro、Jimbo Erika、Aida Kaoru、Shimada Akira、Oikawa Yoichi、Mori Yasumichi、Fujii Takeshi、Koyama Rikako、Kobayashi Kazuhiko、Takeshita Akira、Yagihashi Soroku
    • Journal Title

      Scientific Reports

      Volume: 13 Issue: 1 Pages: 6977-6977

    • DOI

      10.1038/s41598-023-33011-7

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K09036, KAKENHI-PROJECT-21K08541, KAKENHI-PROJECT-22K08682, KAKENHI-PROJECT-22K08678, KAKENHI-PROJECT-21K08534
  • [Journal Article] Immunohistochemical detection of enteroviruses in pancreatic tissues of patients with type 1 diabetes using a polyclonal antibody against 2A protease of Coxsackievirus. J Diabetes Invest2022

    • Author(s)
      Jimbo E, Kobayashi T, Takeshita A, Mine K, Nagafuchi S, Fukui T, Yagihashi S,
    • Journal Title

      J Diabetes Invest

      Volume: 13 Issue: 3 Pages: 435-442

    • DOI

      10.1111/jdi.13700

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K09036, KAKENHI-PROJECT-21K08541
  • [Journal Article] Factors affecting glycemic control in diabetes mellitus complicated by autoimmune pancreatitis.2022

    • Author(s)
      Harai N, Nishimura A, Matsumura K, Suzuki Y, Kikuno S, Kobayashi T, Nagasawa K, Mori Y.
    • Journal Title

      J Diabetes Investing

      Volume: 13 Issue: 8 Pages: 1387-1395

    • DOI

      10.1111/jdi.13791

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K08541
  • [Journal Article] Japanese Type 1 Diabetes Database Study (TIDE-J): rationale and study design2021

    • Author(s)
      Daisuke Chujo, Akihisa Imagawa, Kazuki Yasuda, Hisafumi Yasuda, Toshiaki Hanafus, Hiroshi Kajio, et al.
    • Journal Title

      Diabetology International

      Volume: 13 Issue: 1 Pages: 288-294

    • DOI

      10.1007/s13340-021-00541-2

    • NAID

      40022803046

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07912, KAKENHI-PROJECT-19K09010, KAKENHI-PROJECT-21K08541, KAKENHI-PROJECT-21K08589
  • [Journal Article] Association between insulin-like growth factor 1 and pancreatic volume in type 1 and type 2 diabetes: cross-sectional study of a Japanese population2021

    • Author(s)
      Fukui T, Fukase A , Sasamori H, Ohara M, MorI Y, Terasaki M, Hiromura M, Kushima H, Kobayashi T, Yamagishi S.
    • Journal Title

      Growth Horm IGF Res

      Volume: 59 Pages: 101396-101396

    • DOI

      10.1016/j.ghir.2021.101396

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K08541
  • [Journal Article] Possible Long-Term Efficacy of Sitagliptin, a Dipeptidyl Peptidase-4 Inhibitor, for Slowly Progressive Type 1 Diabetes (SPIDDM) in the Stage of Non-Insulin-Dependency: An Open-Label Randomized Controlled Pilot Trial (SPAN-S)2017

    • Author(s)
      Awata Takuya、Shimada Akira、Maruyama Taro、Oikawa Yoichi、Yasukawa Nobuyuki、Kurihara Susumu、Miyashita Yumi、Hatano Masako、Ikegami Yuichi、Matsuda Masafumi、Niwa Masataka、Kazama Youichiro、Tanaka Shoichiro、Kobayashi Tetsuro
    • Journal Title

      Diabetes Therapy

      Volume: 8 Issue: 5 Pages: 1123-1134

    • DOI

      10.1007/s13300-017-0299-7

    • Data Source
      KAKENHI-PROJECT-15K09406
  • [Journal Article] Pancreatic ductal hyperplasia/dysplasia with obstructive chronic pancreatitis: an association with reduced pancreatic weight in type 1 diabetes.2016

    • Author(s)
      Kobayashi T, Aida K, Fukui T, Jimbo E, Shimada A, Mori Y, Fujii T, Yagihashi S.
    • Journal Title

      Diabetologia

      Volume: 59 Issue: 4 Pages: 865-867

    • DOI

      10.1007/s00125-016-3867-x

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09406, KAKENHI-PROJECT-16K09771
  • [Journal Article] Predictive value of titer of GAD antibodies for further progression of beta cell dysfunction in slowly progressive insulin-dependent (type 1) diabetes (SPIDDM).2016

    • Author(s)
      Tanaka S, Okubo M, Nagasawa K, Takizawa S, Ichijo M, Ichijo S, Kaneshige M, Aida K, Shimura H, Mori Y, Kobayashi T.
    • Journal Title

      Diabetol Int

      Volume: 7 Issue: 1 Pages: 42-52

    • DOI

      10.1007/s13340-015-0211-5

    • NAID

      40020774251

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K09406
  • [Journal Article] 糖尿病診療でみんなが困る疑問を集めました。血糖コントロールがうまくいくコツ】 (第2章)外来診療の疑問 SPIDDM(緩徐進行1型糖尿病)の診断と治療は?2015

    • Author(s)
      小林 哲郎
    • Journal Title

      レジデントノート

      Volume: 16巻17号 Pages: 3166-3170

    • Data Source
      KAKENHI-PROJECT-24591321
  • [Journal Article] Diagnostic criteria for slowly progressive insulin-dependent (type 1) diabetes ellitus (SPIDDM) (2012): report by the Committee on Slowly Progressive Insulin-Dependent (Type 1) Diabetes Mellitus of the Japan Diabetes Society.2015

    • Author(s)
      Tanaka S, Ohmori M, Awata T, Simada A, Mrrao S, Maruyama T, Kamoi K, Kawasaki E, Nakanishi K, Nagata M, Fujii S, Ikegami H, Imagawa A, Uchigata Y, Okubo M, Osawa H, Kajio H, Kawaguchi A, Kawabata Y, Satoh J, Shimizu I, Takahashi K, Makino H, Iwahashi H, Mirra J, Yasuda K, Hanafusa T, Kobayashi T
    • Journal Title

      Diabetol Int

      Volume: 6 Issue: 1 Pages: 1-7

    • DOI

      10.1007/s13340-014-0199-2

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09406, KAKENHI-PROJECT-26461349, KAKENHI-PROJECT-25461368
  • [Journal Article] Skin autofluorescence is a predictor of cardiovascular disease in chronic kidney disease patients.2015

    • Author(s)
      Furuya F, Shimura H, Takahashi K, Akiyama D, Motosugi A, Ikegishi Y, Haraguchi K, Kobayashi T.
    • Journal Title

      Ther Apher Dial.

      Volume: 1 Pages: 40-44

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24591359
  • [Journal Article] 1型糖尿病の発症予防2014

    • Author(s)
      小林 哲郎
    • Journal Title

      内分泌・糖尿病・代謝内科

      Volume: 38巻3号 Pages: 265-268

    • NAID

      40020034749

    • Data Source
      KAKENHI-PROJECT-24591321
  • [Journal Article] Distinct cell clusters touching islet cells induce islet cell replication in association with over-expression of Regenerating Gene (REG) protein in fulminant type 1 diabetes.2014

    • Author(s)
      Aida K, Saitoh S, Nishida Y, Yokota S, Ohno S, Mao X, Akiyama D, Tanaka S, Awata T, Shimada A, Oikawa Y, Shimura H, Furuya F, Takizawa S, Ichijo M, Ichijo S, Itakura J, Fujii H, Hashiguchi A, Takasawa S, Endo T, Kobayashi T.
    • Journal Title

      PLoS One.

      Volume: 9(4)

    • Data Source
      KAKENHI-PROJECT-24591320
  • [Journal Article] Neutrophil gelatinase-associated lipocalin levels associated with cardiovascular disease in chronic kidney disease patients2014

    • Author(s)
      Furuya F, Shimura H, Yokomichi H, Takahashi K, Akiyama D, Asakawa C, Okamura A, Motosugi A, Haraguchi K, Yamagata Z, Kobayashi T.
    • Journal Title

      Clin Exp Nephrol

      Volume: 12

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24591359
  • [Journal Article] Impaired oxidative endoplasmic reticulum stress response caused by deficiency of thyroid hormone receptor α.2014

    • Author(s)
      Takahashi K, Furuya F, Shimura H, Kaneshige M, Kobayashi T.
    • Journal Title

      J Biol Chem.

      Volume: 18 Pages: 12485-12493

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24591359
  • [Journal Article] Activation of the RhoB signaling pathway by thyroid hormone receptor β in thyroid cancer cells.2014

    • Author(s)
      Ichijo S, Furuya F, Shimura H, Hayashi Y, Takahashi K, Ohta K, Kobayashi T, Kitamura K
    • Journal Title

      PLos One

      Volume: 12 Pages: 0116252-0116252

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24591359
  • [Journal Article] 日本先進糖尿病治療研究会によるCSIIおよびCGMに関するステートメント2014

    • Author(s)
      小林 哲郎, 難波 光義, 黒田 暁生, 松久 宗英, 山田 研太郎, 今村 洋一, 金重 勝博, 浜口 朋也, 川村 智行, 佐藤 譲, 高橋 和眞, 丸山 太郎, 西村 理明, 勝野 朋幸, 楠 宜樹, 清水 一紀, 柳澤 克之, 粟田 卓也, 雨宮 伸, 日本先進糖尿病治療研究会
    • Journal Title

      糖尿病

      Volume: 57巻6号 Pages: 403-415

    • NAID

      130004905446

    • Data Source
      KAKENHI-PROJECT-24591321
  • [Journal Article] 理想的なインスリン治療とは? 1型糖尿病2014

    • Author(s)
      田中 昌一郎, 小林 哲郎
    • Journal Title

      Diabetes Contemporary

      Volume: 1巻1号 Pages: 26-31

    • Data Source
      KAKENHI-PROJECT-24591321
  • [Journal Article] Neutrophil gelatinase-associated lipocalin levels associated with cardiovascular disease in chronic kidney disease patients.2014

    • Author(s)
      Furuya F, Shimura H, Yokomichi H, Takahashi K, Akiyama D, Asakawa C, Okamura A, Motosugi A, Haraguchi K, Yamagata Z, Kobayashi T.
    • Journal Title

      Clin Exp Nephrol.

      Volume: 18 Pages: 778-783

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24591359
  • [Journal Article] Antibody-validated proteins in inflamed islets of fulminant type 1 diabetes profiled by laser-capture microdissection followed by mass spectrometry.2014

    • Author(s)
      Nishida Y, Aida K, Kihara M, Kobayashi T
    • Journal Title

      PLOS ONE

      Volume: 9

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24591319
  • [Journal Article] Antibody-validated proteins in inflamed islets of fulminant type 1 diabetes profiled by laser-capture microdissection followed by mass spectrometry.2014

    • Author(s)
      Nishida Y, Aida K, Kihara M, Kobayashi T.
    • Journal Title

      PLoS One.

      Volume: 9(10)

    • Data Source
      KAKENHI-PROJECT-24591321
  • [Journal Article] Impaired oxidative endoplasmic reticulum stress response caused by deficiency of thyroid hormone receptor α2014

    • Author(s)
      Takahashi K, Furuya F, Shimura H, Kaneshige M, Kobayashi T
    • Journal Title

      J Biol Chem

      Volume: in press

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24591359
  • [Journal Article] Diagnostic criteria for acute-onset type 1 diabetes mellitus (2012): Report of the Committee of Japan Diabetes Society on the Research of Fulminant and Acute-onset Type 1 Diabetes Mellitus.2014

    • Author(s)
      Kawasaki E, Maruyama T, Imagawa A, Awata T, Ikegami H, Uchigata Y, Osawa H, Kawabata Y, Kobayashi T, Shimada A, Shimizu I, Takahashi K, Nagata M, Makino H, Hanafusa T.
    • Journal Title

      J Diabetes Investig

      Volume: 12;5(1) Pages: 115-8

    • NAID

      120006986708

    • Data Source
      KAKENHI-PROJECT-24591321
  • [Journal Article] 疾患REVIEW 1型糖尿病 成因、診断、予防と治療2014

    • Author(s)
      小林 哲郎, 会田 薫, 田中 昌一郎
    • Journal Title

      SRL宝函

      Volume: 35巻1号 Pages: 26-36

    • Data Source
      KAKENHI-PROJECT-24591321
  • [Journal Article] Distinct cell clusters touching islet cells induce islet cell replication in association with over-expression of regenerating gene (REG) protein in fulminant type 1 diabetes.2014

    • Author(s)
      Aida K, Saitoh S, Nishida Y, Yokota S, Ohno S, Mao X, Akiyama D, Tanaka S, Awata T, Shimada A, Oikawa Y, Shimura H, Furuya F, Takizawa S, Ichijo M, Ichijo S, Itakura J, Fujii H, Hashiguchi A, Takasawa S, Endo T, Kobayashi T
    • Journal Title

      PLOS ONE

      Volume: 9(4)

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24591319
  • [Journal Article] Distinct cell clusters touching islet cells induce islet cell replication in association with over-expression of Regenerating Gene (REG) protein in fulminant type 1 diabetes.2014

    • Author(s)
      Aida K, Saitoh S, Nishida Y, Yokota S, Ohno S, Mao X, Akiyama D, Tanaka S, Awata T, Shimada A, Oikawa Y, Shimura H, Furuya F, Takizawa S, Ichijo M, Ichijo S, Itakura J, Fujii H, Hashiguchi A, Takasawa S, Endo T, Kobayashi T.
    • Journal Title

      PLoS One.

      Volume: 9(4)

    • Data Source
      KAKENHI-PROJECT-24591321
  • [Journal Article] Ligand-Bound Thyroid Hormone Receptor Contributes to Reprogramming of Pancreatic Acinar Cells Into Insulin-Producing Cells.2013

    • Author(s)
      Furuya F, Shimura H, Asami K, Ichijo S, Takahashi K, Kaneshige M, Oikawa Y, Aida K, Endo T, Kobayashi T.
    • Journal Title

      J Biol Chem.

      Volume: 288(22) Pages: 16155-16166

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24591320
  • [Journal Article] Pathophysiological mechanisms involving aggressive islet cell destruction in fulminant type 1 diabetes2013

    • Author(s)
      Shoichiro TANAKA, Kaoru AIDA, Yoriko NISHIDA, Tetsuro KOBAYASHI
    • Journal Title

      Endocrine Journal

      Volume: 60(7) Pages: 837-845

    • NAID

      10031195751

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24591321
  • [Journal Article] Ligand-bound thyroid hormone receptor contributes to reprogramming of pancreatic acinar cells into insulin-producing cells.2013

    • Author(s)
      Furuya F, Shimura H, Asami K, Ichijo S, Takahashi K, Kaneshige M, Oikawa Y, Aida K, Endo T, Kobayashi T
    • Journal Title

      J Biol Chem

      Volume: 288 Issue: 22 Pages: 16155-16166

    • DOI

      10.1074/jbc.m112.438192

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24591321, KAKENHI-PROJECT-24591359
  • [Journal Article] Immunization of mice with a newly identified thyroid-stimulating hormone receptor splice variant induces Graves'-like disease.2013

    • Author(s)
      Endo T, Kobayashi T.
    • Journal Title

      J Autoimmun.

      Volume: 43 Pages: 18-25

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24591320
  • [Journal Article] Excess TSH causes abnormal skeletal development in young mice with hypothyroidism via suppressive effects on the growth plate.2013

    • Author(s)
      Endo T, Kobayashi T.
    • Journal Title

      Am J Physiol Endocrinol Metab.

      Volume: 305(5)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24591320
  • [Journal Article] Concurrent overexpression of RET/PTC1 and TTF1 confers tumorigenicity to thyrocytes.2013

    • Author(s)
      Endo T, Kobayashi T.
    • Journal Title

      Endocr Relat Cancer

      Volume: 20(6) Pages: 767-776

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24591320
  • [Journal Article] Pathophysiological mechanisms involving aggressive islet cell destruction in fulminant type 1 diabetes2013

    • Author(s)
      Shoichiro TANAKA、Kaoru AIDA、Yoriko NISHIDA, Tetsuro KOBAYASHI
    • Journal Title

      Endocrine Journal

      Volume: 60(7) Pages: 837-845

    • NAID

      10031195751

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24591319
  • [Journal Article] Type 1 Diabetes and Interferon Therapy : Anationwide survey in Japan.; the Research Committee on Type 1 Diabetes of the Japan Diabetes Society2011

    • Author(s)
      Nakamura K, Kawasaki E, Imagawa A, Awata T, Ikegami H, Uchigata Y, Kobayashi T, Shimada A, Nakanishi K, Makino H, Maruyama T, Hanafusa T
    • Journal Title

      Diabetes Care

      Volume: 34 Pages: 2084-2089

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591127
  • [Journal Article] RIG-I- and MDA5-initiated innate immunity linked with adaptive immunity accelerates b-cell death in fulminant type 1 diabetes.2011

    • Author(s)
      Kaoru Aida, Yoriko Nishida, Shoichiro Tanaka, Taro Maruyama, Akira Shimada, Takuya Awata, Masako Suzuki, Hiroki Shimura, Soichi Takizawa, Masashi Ichijo, Daiichiro Akiyama, Fumihiko Furuya, Akio Kawaguchi, Masahiro Kaneshige, Jun Itakura, Hideki Fujii, Toyoshi Endo, Tetsuro Kobayashi
    • Journal Title

      Diabetes 60

      Pages: 884-884

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591055
  • [Journal Article] Thyroid-specific gene expression inchondrocytes2011

    • Author(s)
      Toyoshi Endo, Tetsuro Kobayashi
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 416 Pages: 227-231

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591127
  • [Journal Article] RIG-I-and MDA5-Initiated Innate Immunity Linked With Adaptove Immunity Acceleratesβ-Cell Death in Fulminant Type 1Diabetes2011

    • Author(s)
      Kaoru Aida, Yoriko Nishida, Shoichiro Tanaka, Taro Maruyama, Akira Shimada, Takuya Awata, Masako Suzuki, Hiroki Shimura, Soichi Takizawa, Masashi Ichijo, Daiichiro Akiyama, Fumihiko Furuya, Akio Kawaguchi, Masahiro Kaneshige, Jun Itakura, Hideki Fujii, Toyoshi Endo, and Tetsuro Kobayashi
    • Journal Title

      Diabetes

      Volume: 60 Pages: 884-889

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591127
  • [Journal Article] Runx2 Deficiency in Mice Causes Decreased Thyroglobulin Expression and Hypothyroidism2010

    • Author(s)
      Toyoshi Endo and Tetsuro Kobayashi
    • Journal Title

      Molecular Endocrinology

      Volume: 24 Pages: 1267-1273

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591127
  • [Journal Article] 緩徐進行1型糖尿病(SPIDDM)および2型糖尿病患者におけるCXCL10とインスリン抵抗性に関する検討2010

    • Author(s)
      會田薫, 小林哲郎
    • Journal Title

      Therapeutic Research 31(6)

      Pages: 45-49

    • Data Source
      KAKENHI-PROJECT-20591055
  • [Journal Article] 「II感染症と1型糖尿病劇症1 型糖尿病とウィルス感染」、劇症1型糖尿病とウイルス感染2010

    • Author(s)
      會田薫, 西田頼子, 田中昌一郎, 丸山太郎, 島田朗, 小林哲郎
    • Journal Title

      Diabetes Frontier 21

      Pages: 307-313

    • Data Source
      KAKENHI-PROJECT-20591055
  • [Journal Article] Members of the Japan Diabetes Society's Committee on Research on Type 1Diabetes. Serum glycated albumin tohaemoglobin A1C ratio can distinguish fulminant type 1 diabetes mellitus from type2 diabetes mellitus.2010

    • Author(s)
      Masafumi Koga, Jun Murai, Hiroshi Saito, Soji Kasayama, Akihisa Imagawa, Toshiaki Hanafusa, Tetsuro Kobayashi
    • Journal Title

      Ann Clin Biochem

      Volume: 47 Pages: 313-317

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591127
  • [Journal Article] and the Members of the Japan Diabetes Society's Committee on Research on Type 1 Diabetes.Serum glycated albumin to haemoglobin A1C ratio can distinguish fulminant type 1 diabetes mellitus from type 2 diabetes mellitus.2010

    • Author(s)
      Masafumi Koga, Jun Murai, Hiroshi Saito, Soji Kasayama, Akihisa Imagawa, Toshiaki Hanafusa, Tetsuro Kobayashi
    • Journal Title

      Ann Clin Biochem 47

      Pages: 313-317

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591056
  • [Journal Article] Runx2 Deficiency in Mice Causes Decreased Thyroglobulin Expression and Hypothyroidism.2010

    • Author(s)
      Toyoshi Endo, Tetsuro Kobayashi.
    • Journal Title

      Molecular Endocrinology 24(6)

      Pages: 1267-1273

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591056
  • [Journal Article] Enterovirus Infection, CXC Chemokine Ligand 10 (CXCL10), and CXCR3 Circuit -A Mechanism of Accelerated Beta-Cell Failure in Fulminant Type 1 Diabetes-.2009

    • Author(s)
      Shoichiro Tanaka, Yoriko Nishida, Kaoru Aida, Taro maruyama, Akira Shimada, Masako Suzuki, Hiroki Shimura, Soichi Takizawa, Masashi Takahashi, Daiichiro Akiyama, Sayaka Arai-Yamashita, Fumihiko Furuya, Akio Kawaguchi, Masahiro Kaneshige, Ryohei Katoh, Toyoshi Endo, Tetsuro Kobayashi
    • Journal Title

      Diabetes 58

      Pages: 2285-2291

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591056
  • [Journal Article] 山梨地域糖尿病療養指導士の歩み2009

    • Author(s)
      會田薫, 小林哲郎
    • Journal Title

      肥満と糖尿病5・6 Vol.8 No.3

      Pages: 437-439

    • Data Source
      KAKENHI-PROJECT-20591055
  • [Journal Article] HSP 10 is a new autoantigen in both autoimmune pancreatitis and fulminant type 1 diabetes.2009

    • Author(s)
      Takizawa S, Endo T, Xing Wanjia, Tanaka S, Kobayashi T.
    • Journal Title

      Biochem Biophys Res Commun 386

      Pages: 192-196

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591056
  • [Journal Article] on behalf of the Committee on Type 1 Diabetes, Japan Diabetes Society. Differential association of HLA with three subtypes of type 1 diabetes : fulminant, slowly progressive and acute-onset.2009

    • Author(s)
      Y. Kawabata, H. Ikegami, T.Awata, A.Imagawa, T.Maruyama, E.Kawasaki, S.Tanaka, A.Shimada, H.Osawa, T.Kobayashi, T.Hanafusa, K.Tokunaga, H.Makino
    • Journal Title

      Diabetologia 52

      Pages: 2513-2521

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591056
  • [Journal Article] 緩徐進行1型糖尿病(SPIDDM)の最新の知見2009

    • Author(s)
      小林哲郎
    • Journal Title

      糖尿病 52

      Pages: 673-674

    • Data Source
      KAKENHI-PROJECT-20591055
  • [Journal Article] Immunization with thyroglobulin induces Graves'-like disease in mice.2009

    • Author(s)
      Toyoshi Endo, Tetsuro Kobayashi
    • Journal Title

      Journal of Endocrinology 202

      Pages: 217-222

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591056
  • [Journal Article] Enterovirus Infection, CXC Chemokine Ligand 10 (CXCL10), and CXCR3 Circuit -A Mechanism of Accelerated Beta-Cell Failure in Fulminant Type 1 Diabetes-.2009

    • Author(s)
      Shoichiro Tanaka, Yoriko Nishida, Kaoru Aida, Taro maruyama, Akira Shimada, Masako Suzuki, Hiroki Shimura, Soichi Takizawa, Masashi Takahashi, Daiichiro Akiyama, Sayaka Arai-Yamashita, Fumihiko Furuya, Akio Kawaguchi, Masahiro Kaneshige, Ryohei Katoh, Toyoshi Endo, Tetsuro Kobayashi
    • Journal Title

      Diabetes 58

      Pages: 2285-2291

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591055
  • [Journal Article] Japanese Study Group on Type 1 Diabetes Genetics ; Genetic Association between the Interleukin-2 Receptor-αGene and Modeof Onset of Type 1 Diabetes in the Japanese Population2009

    • Author(s)
      Eiji Kawasaki, Takuya Awata, HiroshiIkegami, Tetsuro Kobayashi, TaroMaruyama, Koji Nakanishi, Akira Shimada Miho Uga, Susumu Kurihara, Yumiko Kawabata, Shoichiro Tanaka, Yasuhiko Kanazawa, Katsumi Eguchi
    • Journal Title

      J Clin Endocrionl Metab

      Volume: 94 Pages: 947-952

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591127
  • [Journal Article] Amylase alpha-2A autoantibodies :Novel Marker of Autoimmune Pancreatitis and Fulminant Type 1 Diabetes2009

    • Author(s)
      Toyoshi Endo, Soichi Takizawa, Shoichiro Tanaka, Masashi Takahashi, Hideki Fujii, Terumi Kamisawa, Tetsuro Kobayashi
    • Journal Title

      Diabetes 58

      Pages: 732-737

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591056
  • [Journal Article] Diabetes associated with autoimmune pancreatitis : new insights into the mechanism of beta-cell dysfunction.2009

    • Author(s)
      Tetsuro Kobayashi, Shoichiro Tanaka, Kaoru Aida,, Soichi Takizawa, Hiroki Shimura, Toyoshi Endo.
    • Journal Title

      Expert Review of Endocrinology & Metabolism. 4

      Pages: 591-602

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591055
  • [Journal Article] Amylase alpha-2A autoantibodies : NovelMarker of Autoimmune Pancreatitis and Fulminant Type 1 Diabetes2009

    • Author(s)
      Toyoshi Endo, Soichi Takizawa, Shoichiro Tanaka, Masashi Takahashi, Hideki Fujii, Terumi Kamisawa, and Tetsuro Kobayashi
    • Journal Title

      Diabetes

      Volume: 58 Pages: 732-737

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591127
  • [Journal Article] 緩徐進行1型糖尿病(SPIDDM)の最近の知見2009

    • Author(s)
      小林哲郎, 田中昌一郎, 会田薫
    • Journal Title

      糖尿病 第52 巻第8号

    • NAID

      10025606536

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591055
  • [Journal Article] on behalf of the Japanese Study Group on Type 1 Diabetes Genetics ; Association of Type 1 Diabeteswith Two Loci on 12q13 and 16p13 and the Influence Coexisting Thyroid Autoimmunityin Japanese2009

    • Author(s)
      Takuya Awata, Eiji Kawasaki, Shoichiro Tanaka, Hiroshi Ikegami, Taro Maruyama, Akira Shimada, Koji Nakanishi, TetsuroKobayashi, Hiroyuki Iizuka, Miho Uga, Yumiko Kawabata, Yasuhiko Kanazawa, Susumu Kurihara, Masataka Osaki, Shigehiro Katayama
    • Journal Title

      J Clin. Endocrinol. Metab

      Volume: 94 Pages: 231-235

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591127
  • [Journal Article] 山梨地区における糖尿病性神経障害に対するアルドース還元酵素阻害薬エパルレスタットの3年間長期投与による臨床効果-投与中止後の臨床経過も含めて-2008

    • Author(s)
      會田薫, 土屋和子, 田中治幸, 新藤英夫, 黒沢理恵, 保坂嘉之, 祢津光廣, 井上正晴, 岩瀬英一, 小林哲郎
    • Journal Title

      Diabetes Frontier 19(4)

      Pages: 522-527

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591055
  • [Journal Article] HSP 10 is a new autoantigen in both autoimmune pancreatitis and fulminant type 1 diabetes

    • Author(s)
      S.Takizawa, T. Endo, Xing Wanjia, S. Tanaka, M. Takahashi, T. Kobayashi
    • Journal Title

      Biochem Biophys Res Commun (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591041
  • [Presentation] 緩徐進行1型糖尿病(SPIDDM)Update2023

    • Author(s)
      小林 哲郎, 内田 貴康, 福井 智康, 及川 洋一, 島田 朗
    • Organizer
      日本先進糖尿病治療研究会
    • Data Source
      KAKENHI-PROJECT-21K08541
  • [Presentation] 膵病変を合併する1型糖尿病の臨床的,遺伝的特徴の検討 日本人1型糖尿病の包括的データベース(TIDE-J)より(会議録)2023

    • Author(s)
      福井 智康, 梶尾 裕, 中條 大輔, 安田 和基, 霜田 雅之, 春日 雅人, 今川 彰久, 池上 博司, 大澤 春彦, 島田 朗, 長澤 幹, 及川 洋一, 安田 尚史, 粟田 卓也, 川崎 英二, 高橋 和眞, 小林 哲郎, 花房 俊昭, 小澤 純二, 香月 健志, 小谷 紀子, 土屋 恭一郎, 堀江 一郎, 能宗 伸輔, 金綱 規夫
    • Organizer
      第66回日本糖尿病学会年次学術集会
    • Data Source
      KAKENHI-PROJECT-21K08541
  • [Presentation] 緩徐進行1型糖尿病における膵島関連自己抗体の評価ー「日本人1型糖尿病包括的データべ―スの構築と臨床研究への展開」よりー2022

    • Author(s)
      小谷紀子、島田朗、川崎英二、福井智康、中條大輔、今川彰久、霜田雅之、寺川瞳子、阿比留教生、粟田卓也、池上博司、及川洋一、大塚春彦、小澤純二、香月健氏志、金重勝博、高橋和眞、土屋恭一郎、長澤幹、能宋伸輔、安田和基、安田尚史、春日雅人、小林哲郎、花房俊昭、梶尾裕
    • Organizer
      第65回日本糖尿病学会年次学術集会
    • Data Source
      KAKENHI-PROJECT-21K08541
  • [Presentation] 劇症1型糖尿病における膵病理の特徴。2022

    • Author(s)
      滝田 美奈子 神保 江莉加, 福井 智康, 会田 薫, 八木橋 操六, 島田 朗, 及川 洋一, 小林 哲郎
    • Organizer
      第21回日本先進糖尿病治療・1型糖尿病研究会
    • Data Source
      KAKENHI-PROJECT-21K08541
  • [Presentation] 1型糖尿病患者膵組織中のEnterovirus 2A proteaseに対するpolyclonal抗体の作成と臨床応用。2022

    • Author(s)
      内田貴康、荏原徹, 荻久保明香, 森保道, 八木橋操六, 三根敬一朗, 永淵正法, 小林哲郎
    • Organizer
      第65回日本糖尿病学会年次学術集会
    • Data Source
      KAKENHI-PROJECT-21K08541
  • [Presentation] 緩徐進行1型糖尿病における膵島関連自己抗体の評価「日本人1型糖尿病の包括的データベースの構築と臨床研究への展開」2022

    • Author(s)
      小谷紀子, 島田朗, 川崎英二, 福井智康, 中條大輔, 今川彰久, 霜田雅之, 寺川瞳子, 阿比留教生, 粟田卓也, 池上博司, 及川洋一, 大澤春彦, 小澤純二, 香月健志, 金重勝博, 高橋和眞, 土屋恭一郎, 長澤幹, 能宗伸輔, 安田和基, 安田尚史, 春日雅人, 小林哲郎, 花房俊昭, 梶尾裕
    • Organizer
      第65回日本糖尿病学会年次学術集会。
    • Data Source
      KAKENHI-PROJECT-21K08541
  • [Presentation] 1 型糖尿病患者膵組織中の Enterovirus 2A protease に対する polyclonal 抗体の作成と臨床応用2022

    • Author(s)
      内田貴康、荏原徹、荻久保明香、森保道、八木橋操六、三根敬一朗、永瀧正法、小林哲郎
    • Organizer
      第65回日本糖尿病学会年次学術集会
    • Data Source
      KAKENHI-PROJECT-21K08541
  • [Presentation] 1型糖尿病の発症時のビタミンD濃度-日本人1型糖尿病の包括的データベースの構築と臨床研究への展開(TIDE-J)よりー2022

    • Author(s)
      長江亮太、橘恵、今川彰久、寺前純吾、金網規夫、小谷紀子、高橋信行、寺川瞳、阿比留教生、粟田卓也、池上博司、能宋伸輔、岩橋博見、及川洋一、島田朗、大澤春彦、川村良一、大津洋、香月健志、金重勝博、川崎英二、小澤純二、小林哲郎、他
    • Organizer
      第65回日本糖尿病学会年次学術集会
    • Data Source
      KAKENHI-PROJECT-21K08541
  • [Presentation] 緩徐進行1型糖尿病膵組織の特徴~1型糖尿病における膵外分泌腺異常を中心に~(シンポジウム)2021

    • Author(s)
      福井 智康、小林 哲郎
    • Organizer
      第64回日本糖尿病学会年次学術集会
    • Data Source
      KAKENHI-PROJECT-21K08541
  • [Presentation] Distinct inflamed changes of the pancreases of slowly progressive insulin-dependent (type 1) diabetes: comparative analysis with enterovirus-nduced fulminant type 1 diabetes.2017

    • Author(s)
      Jimbo E, Kobayashi T, Fukui T, Aida K, Yagihashi S, Shimada A.
    • Organizer
      15th of International Congress of Immunology of Diabetes Society
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09406
  • [Presentation] 緩徐進行1型糖尿病の膵外分泌腺の病理学的検討。2017

    • Author(s)
      福井智康、小林哲郎、神保江莉加、島田朗、八木橋操六、会田薫
    • Organizer
      第60回糖尿病学会年次学術集会
    • Data Source
      KAKENHI-PROJECT-15K09406
  • [Presentation] 1型糖尿病update 2017 緩徐進行1型糖尿病の成因~膵炎と膵島炎の関係に注目して~。2017

    • Author(s)
      福井智康、小林哲郎、八木橋操六
    • Organizer
      第60回糖尿病学会年次学術集会 シンポジウム
    • Data Source
      KAKENHI-PROJECT-15K09406
  • [Presentation] 1型糖尿病の成因と治療】緩徐進行1型糖尿病の成因に関する最新の知見―膵外分泌腺、膵管異常に注目して―2016

    • Author(s)
      福井智康、会田薫、神保江莉加、島田朗、八木橋操六、小林哲郎
    • Organizer
      第59回日本糖尿病学会年次学術集会 (シンポジウム)
    • Place of Presentation
      京都
    • Year and Date
      2016-05-19
    • Data Source
      KAKENHI-PROJECT-15K09406
  • [Presentation] 緩徐進行1型糖尿病(SPIDDM)の病理学的検討2016

    • Author(s)
      神保江莉加、会田薫、福井智康、八木橋操六、島田朗、小林哲郎
    • Organizer
      第59回日本糖尿病学会年次学術集会
    • Place of Presentation
      京都
    • Year and Date
      2016-05-19
    • Data Source
      KAKENHI-PROJECT-15K09406
  • [Presentation] 1型糖尿病と腎疾患 2016年6月17-19日 横浜2016

    • Author(s)
      小林哲郎
    • Organizer
      第59回日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2016-06-17
    • Invited
    • Data Source
      KAKENHI-PROJECT-15K09406
  • [Presentation] 1型糖尿病のすべて 緩徐進行1型糖尿病の膵病変2015

    • Author(s)
      小林哲郎、会田薫、西田頼子、島田朗、八木橋操六、粟田卓也
    • Organizer
      第58回日本糖尿病年次学術総会
    • Place of Presentation
      海峡メッセ下関
    • Year and Date
      2015-05-21
    • Data Source
      KAKENHI-PROJECT-15K09406
  • [Presentation] 劇症1型糖尿病膵島のプロテオミクス解析2013

    • Author(s)
      西田 頼子, 會田 薫, 田中 昌一郎, 小林 哲郎
    • Organizer
      第56回日本糖尿病学会年次学術集会
    • Place of Presentation
      ホテル日航熊本(熊本県熊本市)
    • Data Source
      KAKENHI-PROJECT-24591321
  • [Presentation] 劇症1型糖尿病膵島のプロテオミクス解析2013

    • Author(s)
      西田 頼子、會田 薫、田中昌一郎、小林哲郎
    • Organizer
      第56回日本糖尿病学会年次学術集会
    • Place of Presentation
      ホテル日航熊本(熊本県熊本市)
    • Data Source
      KAKENHI-PROJECT-24591319
  • [Presentation] 膵β細胞における小胞体ストレスは,IFN-γ産生を介してアポトーシスを誘導する2013

    • Author(s)
      一條 昌志, 志村 浩己, 古屋 文彦, 一條 沙耶花, 滝澤 壮一, 田中 昌一郎, 會田 薫, 遠藤 登代志, 小林 哲郎
    • Organizer
      第56回日本糖尿病学会年次学術集会
    • Place of Presentation
      ホテル日航熊本(熊本県熊本市)
    • Data Source
      KAKENHI-PROJECT-24591321
  • [Presentation] Ligand-bound thyroid hormone receptor contributes to reprogramming of pancreatic acinar cells2013

    • Author(s)
      Furuya F, Shimura H, Ichijo S, Ichijo M, Hayashi Y, Kobayashi T.
    • Organizer
      ENDO2013
    • Place of Presentation
      モスコーセンター(サンフランシスコ)
    • Data Source
      KAKENHI-PROJECT-24591359
  • [Presentation] 劇症1型糖尿病膵島のプロテオミクス解析2013

    • Author(s)
      西田 頼子, 會田 薫, 田中 昌一郎, 小林 哲郎
    • Organizer
      第11回1型糖尿病研究会
    • Place of Presentation
      軽井沢プリンスホテル(長野県 軽井沢)
    • Data Source
      KAKENHI-PROJECT-24591321
  • [Presentation] 「緩徐進行1型糖尿病の成因」熊本市、5月16-18日2013

    • Author(s)
      小林哲郎、会田薫、西田頼子、田中昌一郎
    • Organizer
      第56回日本糖尿病学会総会シンポジウム
    • Place of Presentation
      ホテル日航熊本(熊本県熊本市)
    • Invited
    • Data Source
      KAKENHI-PROJECT-24591319
  • [Presentation] 膵内分泌細胞における甲状腺ホルモン受容体(TRα)の作用の検討2013

    • Author(s)
      古屋文彦、高橋和也、一條沙耶花、遠藤登代志、小林哲郎
    • Organizer
      第56回日本甲状腺学会
    • Place of Presentation
      和歌山県民文化会館(和歌山市)
    • Data Source
      KAKENHI-PROJECT-24591359
  • [Presentation] 膵β細胞におけるIFNγ発現についての検討2012

    • Author(s)
      一條 昌志, 志村 浩己, 滝澤 壮一, 古屋 文彦, 田中 昌一郎, 會田 薫, 遠藤 登代志, 小林 哲郎.
    • Organizer
      第55回日本糖尿病学会年次学術集会
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Data Source
      KAKENHI-PROJECT-24591320
  • [Presentation] 劇症1型糖尿病と緩徐進行1型糖尿病の膵:その異質性2011

    • Author(s)
      会田薫,西田頼子,田中昌一郎,丸山太郎,島田朗,栗田卓也,小林哲郎
    • Organizer
      第54回日本糖尿病学会年次学術集会
    • Place of Presentation
      札幌市
    • Year and Date
      2011-05-20
    • Data Source
      KAKENHI-PROJECT-21591127
  • [Presentation] 日本糖尿病学会1型糖尿病調査研究委員会:劇症1型糖尿病症例における腹部MRI所見についての検討2011

    • Author(s)
      徳永あゆみ,西尾博,早田敏,今川彰久,下村伊一郎,小林哲郎,花房俊昭
    • Organizer
      第54回日本糖尿病学会年次学術集会
    • Place of Presentation
      札幌市
    • Year and Date
      2011-05-21
    • Data Source
      KAKENHI-PROJECT-21591127
  • [Presentation] 劇症1型糖尿病膵(FT1D)における自然免疫/獲得免疫関連分子の発現2011

    • Author(s)
      西田頼子,会田薫,田中昌一郎,丸山太郎,島田朗,粟田卓也,小林哲郎
    • Organizer
      第54回日本糖尿病学会年次学術集会2011
    • Place of Presentation
      札幌市
    • Year and Date
      2011-05-21
    • Data Source
      KAKENHI-PROJECT-21591127
  • [Presentation] Pathlogical changes in the pancreas of fulminant type 1 diabetes and slowly progressive insulin-dependent(type 1)diabetes2010

    • Author(s)
      T.Kobayashi
    • Organizer
      The 11^<th> International congress of the immunology of diabetes society
    • Place of Presentation
      INCHEON KOREA
    • Year and Date
      2010-11-02
    • Data Source
      KAKENHI-PROJECT-20591056
  • [Presentation] 劇症1型糖尿病における自己抗体認識抗原であるアミラーゼの膵島での発現調節機構および機能の解析2010

    • Author(s)
      青柳美帆,志村浩己,滝澤壮一,高橋昌志,山下さやか,古屋文彦,田中昌一郎,遠藤登代志,小林哲郎
    • Organizer
      第53回日本糖尿病学会年次学術集会
    • Place of Presentation
      岡山
    • Year and Date
      2010-05-27
    • Data Source
      KAKENHI-PROJECT-21591127
  • [Presentation] Pathological changens in the pancreas of fulminant type 1 diabetes and slowly progressive insulin dependent (type1) diabetes.2010

    • Author(s)
      小林哲郎, 會田薫, 田中昌一郎
    • Organizer
      The 11th International Congress of the Immunology of Diabetes Society.
    • Place of Presentation
      Korea
    • Data Source
      KAKENHI-PROJECT-20591055
  • [Presentation] 日本糖尿病学会1型糖尿病調査研究委員会.妊娠中発症の劇症1型糖尿病のGA/HbA1c比測定の有用性2010

    • Author(s)
      村井潤,古賀正史,斎藤博,笠山宗生,清水一紀,小林哲郎,今川彰久,花房俊昭
    • Organizer
      第53回日本糖尿病学会年次学術集会
    • Place of Presentation
      岡山
    • Year and Date
      2010-05-27
    • Data Source
      KAKENHI-PROJECT-21591127
  • [Presentation] 1型糖尿病の膵病変:劇症1型糖尿病と緩徐進行1型糖尿病の対比から2010

    • Author(s)
      会田薫,西田頼子,田中昌一郎,丸山太郎,島田朗,小林哲郎
    • Organizer
      第53回日本糖尿病学会年次学術2010
    • Place of Presentation
      岡山
    • Year and Date
      2010-05-27
    • Data Source
      KAKENHI-PROJECT-21591127
  • [Presentation] Pathlogical changes in the pancreas of fulminant type 1 diabetes and slowly progressive insulin-dependent(type1) diabetes.2010

    • Author(s)
      Tetsurou Kobayashi, Kaoru Aida, Shoichiro Tanaka
    • Organizer
      The 11th International congress of the immunology of diabetes society.
    • Place of Presentation
      songdo convensia, Incheon Korea
    • Data Source
      KAKENHI-PROJECT-20591056
  • [Presentation] UK-Japan Workshop ~Frontiers of Diabetes Research~ ; Causes, Pathophysiology and Treatment of Type 1 Diabetes in Japan2009

    • Author(s)
      Tetsuro Kobayashi
    • Organizer
      Science and Innovation Section
    • Place of Presentation
      British Embassy Tokyo
    • Data Source
      KAKENHI-PROJECT-20591056
  • [Presentation] 抗GAD抗体及びIA-2抗体ともに陽性を示した劇症1型糖尿病の1例2009

    • Author(s)
      石原千尋,伊藤祐子,金重勝博,志村浩己,太田一保,小林哲郎
    • Organizer
      第46回日本糖尿病学会関東甲信越地方会
    • Place of Presentation
      横浜市
    • Year and Date
      2009-01-24
    • Data Source
      KAKENHI-PROJECT-21591127
  • [Presentation] Slowly progressive insuhn-dependent(type 1)diabetes mellitus2009

    • Author(s)
      T.Kobayashi
    • Organizer
      第52回日本糖尿病学会学術集会
    • Place of Presentation
      大阪市
    • Data Source
      KAKENHI-PROJECT-20591056
  • [Presentation] Novel autoantibody against heat shock protein 10 in diabetes associated with autoimmune pancreatitis and fulminant type 1 diabetes2008

    • Author(s)
      Souichi Takizawa, Toyoshi Endo, Shoichiro Tanaka, Masashi Takahashi, Tetsuro Kobayashi
    • Organizer
      68th Scientific Sessions of American Diabetes Association
    • Place of Presentation
      Chicago. USA
    • Year and Date
      2008-06-16
    • Data Source
      KAKENHI-PROJECT-19591041
  • [Presentation] Amylase Gene is expressed in pancreatic Beta-Cell Line and increasedby Th1 cytokines.2008

    • Author(s)
      T. Kobayashi, et al
    • Organizer
      68^<th> Scientific Sessions of American DiabetesAssociation
    • Place of Presentation
      San Francisco
    • Year and Date
      2008-06-08
    • Data Source
      KAKENHI-PROJECT-20591056
  • [Presentation] A novel autoantibody against heat shock protein 10 in diabetes associated with autoimmune pancreatitis and fulminant type 1 diabetes.2008

    • Author(s)
      Souichi Takizawa, Toyoshi Endo, Shoichiro Tanaka, Masashi Takahashi, Tetsuro Kobayashi
    • Organizer
      68th Scientific Sessions.
    • Place of Presentation
      San Francisco, USA
    • Data Source
      KAKENHI-PROJECT-20591056
  • [Presentation] Scientific Program Jakarta Diabetes Meeting 2008 ; Plenary Lecture I2008

    • Author(s)
      Tetsuro Kobayashi
    • Organizer
      Immunological Aspect of Type 2 Diabetes : Pathophsiology and clinical Implication
    • Place of Presentation
      Jakarta, Indonesia
    • Data Source
      KAKENHI-PROJECT-20591056
  • [Presentation] 自己免疫性膵炎と劇症1型糖尿病に検出される膵外分泌抗体の対応抗原2008

    • Author(s)
      滝澤壮一、遠藤登代志、田中昌一郎、小林哲郎
    • Organizer
      第51回日本糖尿病学会年次学術集会
    • Place of Presentation
      東京
    • Year and Date
      2008-05-23
    • Data Source
      KAKENHI-PROJECT-19591041
  • [Presentation] 1型糖尿病の成因 最先端研究はどこまで解明されたか緩徐進行1型糖尿病の成因と診断基準

    • Author(s)
      小林哲郎、田中昌一郎、会田薫
    • Organizer
      第57回日本糖尿病学会年次学術集会シンポジウム
    • Place of Presentation
      リーガロイヤルホテル(大阪)
    • Year and Date
      2014-05-22 – 2014-05-24
    • Data Source
      KAKENHI-PROJECT-24591319
  • [Presentation] 筋組織へのアミラーゼ遺伝子導入が1型糖尿病の病態に及ぼす影響の検討

    • Author(s)
      田中 昌一郎, 滝澤 壮一, 一條 昌志, 志村 浩己, 倭 英司, 宮崎 純一, 小林 哲郎
    • Organizer
      第57回日本糖尿病学会年次学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2014-05-22 – 2014-05-24
    • Data Source
      KAKENHI-PROJECT-24591321
  • [Presentation] 劇症1型糖尿病の膵島内に存在するReg-1αを強発現する腺房細胞様細胞

    • Author(s)
      会田薫、斉藤成、西田頼子、横田貞記、大野伸一、茅暁陽、秋山大一郎、高沢伸、小林哲郎
    • Organizer
      第57回日本糖尿病学会年次学術集会
    • Place of Presentation
      大阪国際会場(大阪)
    • Year and Date
      2014-05-22 – 2014-05-24
    • Data Source
      KAKENHI-PROJECT-24591319
  • [Presentation] 緩徐進行1型糖尿病の膵病変

    • Author(s)
      小林哲郎、会田薫、西田頼子、島田朗、八木橋操六、粟田卓也
    • Organizer
      第58回日本糖尿病学会年次学術集会シンポジウム
    • Place of Presentation
      下関
    • Year and Date
      2015-05-21 – 2015-05-24
    • Data Source
      KAKENHI-PROJECT-24591319
  • [Presentation] 日本人1型糖尿病の包括的データベースの構築と臨床研究への展開(TIDE-J)(第2報)

    • Author(s)
      梶尾 裕, 中條 大輔, 安田 和基, 春日 雅人, 花房 俊昭, 今川 彰久, 池上 博司, 大澤 春彦, 川崎 英二, 粟田 卓也, 高橋 和眞, 小林 哲郎, 島田 朗, 安田 尚史
    • Organizer
      第57回日本糖尿病学会年次学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2014-05-22 – 2014-05-24
    • Data Source
      KAKENHI-PROJECT-24591321
  • [Presentation] インスリン非依存GAD抗体陽性糖尿病におけるDPP-4阻害薬シタグリプチンの有効性の検討 SPAN-S(第2報)

    • Author(s)
      栗原 進, 波多野 雅子, 皆川 晃伸, 片山 茂裕, 島田 朗, 小林 哲郎, 風間 要一郎, 丹羽 正孝, 松田 昌文, 粟田 卓也
    • Organizer
      第57回日本糖尿病学会年次学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2014-05-22 – 2014-05-24
    • Data Source
      KAKENHI-PROJECT-24591321
  • [Presentation] Ligand-bound thyroid hormone receptor B induces cancer cell cycle arrest.

    • Author(s)
      Furuya F, Takahashi K, Shimura H, Ichizyo S, Kobayashi T,
    • Organizer
      The endocrine society’s annual meeting and expo, ENDO2014
    • Place of Presentation
      Chicago
    • Year and Date
      2014-06-21 – 2014-06-24
    • Data Source
      KAKENHI-PROJECT-24591359
  • [Presentation] 1型糖尿病の成因 最先端研究はどこまで解明したか 緩徐進行1型糖尿病の成因と診断基準

    • Author(s)
      小林 哲郎, 田中 昌一郎, 会田 薫
    • Organizer
      第57回日本糖尿病学会年次学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2014-05-22 – 2014-05-24
    • Data Source
      KAKENHI-PROJECT-24591321
  • [Presentation] 低抗体価GAD抗体陽性やIA-2抗体単独陽性の2型糖尿病ではインスリン治療による膵β細胞保護効果が期待できる

    • Author(s)
      田中 昌一郎, 小林 哲郎, 会田 薫
    • Organizer
      第57回日本糖尿病学会年次学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2014-05-22 – 2014-05-24
    • Data Source
      KAKENHI-PROJECT-24591321
  • [Presentation] 劇症1型糖尿病の膵島内に存在するReg-1αを強発現する腺房細胞様細胞(ATLANTIS)

    • Author(s)
      会田 薫,齋藤 成, 西田 頼子, 横田 貞記, 大野 伸一, 茅 曉陽, 秋山 大一郎, 高沢 伸, 小林 哲郎
    • Organizer
      第57回日本糖尿病学会年次学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2014-05-22 – 2014-05-24
    • Data Source
      KAKENHI-PROJECT-24591321
  • 1.  NAKANISHI Koji (80211423)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 2.  KANESHIGE Masahiro (20377518)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 6 results
  • 3.  AIDA Kaoru (50184015)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 4.  ENDO Toyoshi (00152017)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 14 results
  • 5.  TANAKA Syoichiro (70377521)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 2 results
  • 6.  TAKIZAWA Souichi (80456467)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 6 results
  • 7.  水谷 哲也 (70281681)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  ICHIJO Masashi (50436854)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 9.  FURUYA Fumihiko (90456450)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 9 results
  • 10.  SHIMURA Hiroki (40303416)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 8 results
  • 11.  MURASE Toshio (60107612)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  TSUKADA Masayasu (90072595)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  OKUBO Minoru (60241238)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  OMORI Masayuki (40372502)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  HARII Norikazu (80377522)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  永淵 正法 (00150441)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  雨宮 三千代 (00288101)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  竹下 章 (20322646)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  内田 貴康 (90948085)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  SIKI Akira
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  YASUDA Hisafumi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 22.  会田 薫
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 35 results
  • 23.  八木橋 操六
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results

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