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Fukuda Satoru  福田 悟

ORCIDConnect your ORCID iD *help
… Alternative Names

福田 悟  フクダ サトル

FUKUDA Satoru  福田 悟

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Researcher Number 30116751
Other IDs
External Links
Affiliation (Current) 2025: 昭和大学, 医学部, 客員教授
Affiliation (based on the past Project Information) *help 2015 – 2016: 昭和大学, 医学部, 教授
2010 – 2012: 帝京大学, 医学部, 教授
2008: Teikyo University, 医学部・麻酔科, 教授
2006 – 2008: 帝京大学, 医学部, 教授
2003 – 2005: 福井大学, 医学部, 教授 … More
2002: Fukui Medical University, Faculty of Medicine, Professor, 医学部, 教授
2001: 福井医科大学, 医学部・附属病院, 教授
1999 – 2000: 福井医科大学, 医学部, 教授
1988 – 1998: 新潟大学, 医学部, 助教授 Less
Review Section/Research Field
Principal Investigator
Anesthesiology/Resuscitation studies / Anesthesiology/Resuscitation studies / 麻酔学
Except Principal Investigator
Anesthesiology/Resuscitation studies / 麻酔学 / Anesthesiology / Anesthesiology/Resuscitation studies
Keywords
Principal Investigator
オレキシン / 脳波 / 視床下部 / Isoflurane / イソフルレン / Hypoxia / 低酸素 / アセチルコリン / 脳室内投与 / 麻酔 … More / 筋電図 / ラット / Glutamate / Acetylcholine / Electroencephalogram / Basal forebrain / Chorinergic arousal system / Hypothalamus / Orexin / ヒスタミン / pedunculopontine tegmentum nucleus / コリン作動性神経系 / サポリン / Pedunculopontine tegmentum nueleus / GABA / cholinergic arousal system / グルタミン酸 / イソフルラン / 前脳基底核 / コリン作動性覚醒システム / Ketamine / Anesthetics / Hypoperfusion / Reoxygenation / Brain Hypoxia / Brain ischemia / Cell adhesion molecule / NO / 虚血 / 細胞接着因子 / サイオペンタール / ケタミン / 麻酔薬 / 低灌流 / 再酸素化 / 脳低酸素 / 接着分子 / White blood cell / Nerve / Endothelium / Acikosis / Microvessel / 血液細胞 / 白血球 / 神経 / 内皮 / アシドーシス / 微小血管 / Vascular smooth muscle / Calcium / Adventitia / Endothlium / 血管内皮 / アシド-シス / 血管平滑筋 / カルシウム / 血管外膜 / 血管内皮(膜) / 麻酔機序 / マイクロダイアリシス / アセチルコリン / REM睡眠 / 海馬 / Neuropeptide EI / 記憶 / 睡眠・覚醒 / メラニン凝集ホルモン / ノンレム睡眠 / レム睡眠 / 睡眠・覚醒中枢 / ヘマトキシリン・エオジン染色 / 中大脳動脈 / 虚血・再灌流 / 脳室内 / 免疫組織染色 / HMGB1 / 睡眠・覚醒障害 / 脳梗塞 / 睡眠・覚醒サイクル / 脳虚血 / nitrotyrosine / Peroxynitrite / 中大脳動脈閉塞モデル / NO_3 / NO_2 / NO(一酸化窒素) / peroxynitrite / 中大脳動脈閉塞・再灌流 … More
Except Principal Investigator
Rho-kinase / 敗血症 / peroxynitrite / 細胞内カルシウム / 血管平滑筋 / 集中治療 / 脳・神経 / HMGB1 / 脳室内投与 / マイクロダイアリシス / メラトニン / 松果体 / 睡眠・覚醒 / 敗血症性脳症 / Regional Metabolic Activity / Nerve Growth Factor / Intracellular Free Calcium / Anti-Ischemic Activity / Brain Injury / 神経生成因子 / 局麻痙攣 / 脳保護作用 / 体温 / 抗脳虚血作用 / 機械的脳損傷 / 局所脳代謝 / ^<14>Cーデオキシグルコ-ス / 細胞内遊離カルシウムイオン / 脳虚血 / 脳保護 / 低酸素・無グルコ-ス / 細胞内Ca^<2+> / 海馬切片 / 局所代謝活性 / 神経成長因子 / 細胞内遊離カルシウム / 抗虚血作用 / 脳損傷 / SPINAL CORD / SUBARACHNOID SPACE / EPIDURAL SPACE / FINE ENDOSCOPE / FIBERSCOPE / ファイバースコープ / 内視鏡 / クモ膜下 / 硬膜外 / 脊髄 / クモ膜下腔 / 硬膜外腔 / 微小内視鏡 / ファイバ-スコ-プ / intracellular calcium / protein kinase C / プロテインキナーゼC / functional examination / absorbance / super oxide / nitric oxide / septic shock / vasoconstraction / catecholamine / 血圧 / ノルアドレナリン / epinephrine / dopamine / 機能実験 / 吸光度 / スーパーオキシド / 一酸化窒素 / 敗血症性ショック / 血管収縮 / ノルエピネフリン / パーオキシナイトライト / visual quality / recording physiological events / surgical manipulation / drug administration / working channel / angling / ultrafine / fiberscope / 画質 / 生体現象測定 / 外科的操作 / 薬物投与 / チャンネル / アングル / 超微小 / 脊髄鏡 / Peripheral blood flow / Chronic pain / Near infrared spectrometry / Epidural block / Spinal cord stimulation / 除痛効果 / 近赤外線酸素モニター / 筋組織酸素動態 / 多目的硬膜外カテーテル電極 / 皮膚温 / 血流変化 / 末梢循環 / 慢性疼痛 / 近赤外線分光モニター / 硬膜外ブロック / 硬膜外脊髄通電 / Knock-out mice / NMDA receptor / Receptor channel / Intracellular Ca^<2+> / Hippocampal slice / Microinjury / Anti-brain ischemia / ケタミン / NMDAリセプタサブユニット / 卵母細胞 / 虚血性神経細胞死 / ペントバルビタール / AMPA受容体 / 分子生物学 / 虚血性神経細胞壊死 / サブユニット / ハロヘリドール / MK-801 / 抗脳虚血機構 / ノックアウトマウス / NMDA受容体 / 受容体チャネル / 海馬スライス / 微細損傷 / 抗脳虚血 / 視床下部 / アセチルコリン / arousal system / 脳波 / イソフルラン / オレキシン / プロポフォール / フェンタニール / off-pumpCABG / VEP / 術後視覚障害 / 心臓手術 / 画像解析 / 微量注入 / fura-2 / カルシウムイオン / KCl / アルギニンバゾプレッシン / 細胞内Caイオン濃度 / 細胞培養 Less
  • Research Projects

    (19 results)
  • Research Products

    (26 results)
  • Co-Researchers

    (38 People)
  •  敗血症性脳症時の睡眠・覚醒異常の解明―視交叉上核とメラトニン動態を探る―

    • Principal Investigator
      坂本 英俊
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology
    • Research Institution
      Teikyo University
  •  A new approach to explore the mechanism of anesthesia-induced unconsciousness. - The role of the hypothalamic MCH neurons -Principal Investigator

    • Principal Investigator
      FUKUDA Satoru
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      Teikyo University
  •  Analysis of sleep-wake disturbance after brain infarction - contribution of dysfunctional orexin cells -Principal Investigator

    • Principal Investigator
      FUKUDA Satoru
    • Project Period (FY)
      2006 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      Teikyo University
  •  脳覚醒中枢のメカニズムに迫る―オレキシン細胞による麻酔導入から覚醒への制御機構―

    • Principal Investigator
      鈴木 久人
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      University of Fukui
  •  脳虚血後意識障害の病態解明Principal Investigator

    • Principal Investigator
      福田 悟
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      University of Fukui
  •  New aspects of the mechanism of emergence from anesthesia -A research for the antagonistic action of orexin, a cerebral excitatory neurotransmitter, against anesthesia-Principal Investigator

    • Principal Investigator
      FUKUDA Satoru
    • Project Period (FY)
      2003 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      University of Fukui
      福井医科大学
  •  心臓手術中の中枢神経モニタリング―視覚誘発電位の有用性―

    • Principal Investigator
      森 芳映
    • Project Period (FY)
      2002
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      福井医科大学
  •  Role of Rho-kinase in cerebral vasospasm and effect of inhalational anesthetics

    • Principal Investigator
      FUJIHARA Hideyoshi
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      UNIVERSITY OF FUKUI
      福井医科大学
  •  Study on pathophysiology on septic shock - A role of nitro-catecholamines-

    • Principal Investigator
      TAKAKURA Ko
    • Project Period (FY)
      2000 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      Fukui Medical University
  •  Attachments of a Tip-Angling Device and a Working Channel : Development of the Multipurpose Ultrafine Spinal Fiberscope

    • Principal Investigator
      SHIMOJI Koki
    • Project Period (FY)
      1998 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      NIIGATA UNIVERSITY
  •  Epidural spinal cord stimulation versus epidural block : comparison with subjective symptomes and peripheral blood flow

    • Principal Investigator
      TOMITA Misao, 早津 恵子
    • Project Period (FY)
      1997 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      NIIGATA UNIVERSITY
  •  The role of cell adhesion molecules of inflammatory cell & brain endothe-lial cell in post brain ischemic/hypoxic hypoperfusionPrincipal Investigator

    • Principal Investigator
      FUKUDA Satoru
    • Project Period (FY)
      1996 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      NIIGATA UNIVERSITY
  •  血管平滑筋細胞内カルシウムの画像解析による吸入麻酔薬の作用機序の解明

    • Principal Investigator
      FUJIHARA Hideyoshi
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      Niigata University
  •  Research on intrinsic anti-ischemic mechanisms : From the standpoint of cell membrane and receptor channel mechanisms

    • Principal Investigator
      SHIMOJI Koki
    • Project Period (FY)
      1994 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      Niigata University
  •  The function of endothelium, nerve and blood cells in microcirculation.-The effect of hypoxia and acidosis-Principal Investigator

    • Principal Investigator
      FUKUDA Satoru
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      Niigata University
  •  血管平滑筋細胞内カルシウム動態の画像解析(低酸素アシド-シス麻酔薬及び血管拡張物質の影響)

    • Principal Investigator
      TAGA Kiichiro
    • Project Period (FY)
      1991 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      麻酔学
    • Research Institution
      Niigata University
  •  Regulation of vascular tone by endothelium, nerve and blood cells through their reciprocal actions.Principal Investigator

    • Principal Investigator
      FUKUDA Satoru
    • Project Period (FY)
      1991 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      麻酔学
    • Research Institution
      Niigata University
  •  Induction and Identification of Endogenous Anti-Ischemic Mechanisms (Factors)

    • Principal Investigator
      SHIMOJI Koki
    • Project Period (FY)
      1988 – 1991
    • Research Category
      Grant-in-Aid for General Scientific Research (A)
    • Research Field
      麻酔学
    • Research Institution
      Nigata University
  •  DEVELOPMENTS OF FINE FIBERSCOPES AND IMAGE-ENHANCEMENT SYSTEM FOR EPIDURAL AND SUBARACHNOID SPACES

    • Principal Investigator
      SHIMOJI Koki
    • Project Period (FY)
      1987 – 1989
    • Research Category
      Grant-in-Aid for Developmental Scientific Research
    • Research Field
      麻酔学
    • Research Institution
      NIIGATA UNIVERSITY

All 2016 2013 2012 2011 2008 2007 2006 2004 2003 2002 Other

All Journal Article Presentation Book

  • [Book] 臨床麻酔学全書(上巻)(花岡一雄, 真下 節, 福田和彦編集)2002

    • Author(s)
      福田 悟
    • Publisher
      真興交易
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370482
  • [Journal Article] Melanin concentrating hormone induces hippocampal acetylcholine release via the medial septum in rats2013

    • Author(s)
      Zhi-hong Lu, Satoru Fukuda, Yoichi Minakawa, Atsushi Yasuda, Hidetoshi Sakamoto, Shigehito Sawamura, Hidenori Takahashia, Noriko Ishii
    • Journal Title

      Peptides

      Volume: 44 Pages: 32-29

    • Data Source
      KAKENHI-PROJECT-22591718
  • [Journal Article] 自然睡眠・覚醒神経回路におけるオレキシンの役割-麻酔からの覚醒に関与する神経ペプチド2008

    • Author(s)
      福田 悟、坂本英俊、蒲生早苗、森田茂穂
    • Journal Title

      Anesthesia 21 Century 10

      Pages: 1818-1826

    • Data Source
      KAKENHI-PROJECT-18390427
  • [Journal Article] アセチルコリン覚醒システムにおけるオレキシンの役割-オレキシンによる麻酔からの覚醒-2007

    • Author(s)
      福田 悟、Zhu Z、森田茂穂
    • Journal Title

      麻酔 56

      Pages: 19-29

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390427
  • [Journal Article] オレキシンの生体での多面性とその可能性2007

    • Author(s)
      福田 悟
    • Journal Title

      麻酔 56

      Pages: 2-8

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390427
  • [Journal Article] Orexins increase cortical acetylcholine release and electroencephalographic activation through orexin-1 receptor in the rat basal forebrain during isoflurane anesthesia.2006

    • Author(s)
      Dong HL, Fukuda S, Murata E, Zu Z, Higuchi T
    • Journal Title

      Anesthesiology 104

      Pages: 1023-1032

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390472
  • [Journal Article] Excitatory and inhibitory actions of isoflurnae on the cholinergic ascending arousal system of the rat.2006

    • Author(s)
      Dong HL, Fukuda S, Murata E, Higuchi T
    • Journal Title

      Anesthesiology 104

      Pages: 122-132

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390472
  • [Journal Article] Excitatory and inhibitory actions of isoflurane on the cholinergic ascending arousal system of the rat2006

    • Author(s)
      Dong HL, Fukuda S, Murata E, Higuchi T.
    • Journal Title

      Anesthesiology 104

      Pages: 122-132

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390472
  • [Journal Article] Orexins increase cortical acetylcholine release and electroencephalographic activation through orexin-1 receptor in the rat basal forebrain during isoflurane anesthesia2006

    • Author(s)
      Dong HL, Fukuda S, Murata E, Zhu Z, Higuchi T.
    • Journal Title

      Aneshtesiology 104

      Pages: 1023-1032

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390472
  • [Journal Article] Excitatory and Inhibitory Actions of Isoflurane on the Cholinergic Ascending Arousal System of the Rat2006

    • Author(s)
      Dong HL, Fukuda S, Murata E, Higuchi T
    • Journal Title

      Anesthesiology 104

      Pages: 122-132

    • Data Source
      KAKENHI-PROJECT-15390472
  • [Journal Article] Orexins2004

    • Author(s)
      Suzuki H, Yasuda Y, Eguchi H, Dong HL, Tateyama H, Isada T, Takeuchi K, Mizoguchi K, Nobukawa Y, Tomita Y, Fujihara H, Fukuda S
    • Journal Title

      Clinical Anesthesia 28-8

      Pages: 1377-1383

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390472
  • [Journal Article] オレキシン2004

    • Author(s)
      鈴木久人, 安田善一, 江口広毅, 菫 海龍, 立山博一, 伊佐田哲朗, 竹内健二, 溝口恭子, 信川泰成, 冨田優子, 冨士原秀善, 福田 悟
    • Journal Title

      臨床麻酔 28・8

      Pages: 1377-1383

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390472
  • [Journal Article] Orexin A elicits arousal electroencephalogram without sympathetic cardiovascular activation in isoflurane-anesthetized rats2003

    • Author(s)
      Yasuda Y, Takeda A, Fukuda S, Suzuki H, Ishimoto M, Mori Y, Eguchi H, Saitoh R, Fujihara H, Honda K, Higuchi T.
    • Journal Title

      Anesth & Analg 97

      Pages: 1663-1666

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390472
  • [Journal Article] Orexin A elicits arousal electroencephalogram without sympathetic cardiovascular activation in isoflurane-anesthetized rats.2003

    • Author(s)
      Yasuda Y, Takeda A, Fukuda S, Suzuki H, Ishimoto M, Mori Y, Eguchi H, Saitoh R, Fujihara H, Honda K, Higuchi T
    • Journal Title

      Anesth Analg 97

      Pages: 1663-1666

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390472
  • [Journal Article] Hemostasis and blood coagulation.2002

    • Author(s)
      Fukuda, S.
    • Journal Title

      Clinical Anesthesia Series (Shinko-Koeki)

      Pages: 231-245

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370482
  • [Journal Article] Orexins Increase Cortical Acetylcholine Release and Electroencephalogram Activation through Orexin-1 Receptor in the Rat Basal Forebrain under Isoflurane Anesthesia

    • Author(s)
      Dong HL, Fukuda S, Murata E, Zhu Z, Higuchi T
    • Journal Title

      Anesthesiology (In press)

    • Data Source
      KAKENHI-PROJECT-15390472
  • [Presentation] ラットにおける生体内マイクロダイアリシス法によるメラトニン測定の新手法の確立2016

    • Author(s)
      藤本 萌、坂本 英俊、 福田 悟、出口 亮、 澤村 成史
    • Organizer
      日本麻酔科学会第63回学術集会
    • Place of Presentation
      福岡県福岡市
    • Year and Date
      2016-05-26
    • Data Source
      KAKENHI-PROJECT-15K10545
  • [Presentation] ラットにおける生体内マイクロダイアリシス法によるメラトニン測定の新手法の確立2016

    • Author(s)
      藤本 萌、坂本英俊、福田 悟、出口 亮、澤村成史
    • Organizer
      日本麻酔科学会第63回学術集会
    • Place of Presentation
      福岡国際会議場(福岡県福岡市)
    • Year and Date
      2016-05-26
    • Data Source
      KAKENHI-PROJECT-15K10545
  • [Presentation] メラニン凝集ホルモンの記憶促進作用2012

    • Author(s)
      皆川 陽一、路 志紅、福田 悟、坂本 英俊、澤村 成史、高橋 秀則
    • Organizer
      日本麻酔科学会第59回学術集会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-22591718
  • [Presentation] Effects of intraventricular melanin-concentrating hormone (MCH) microinjections on sleep and cortical acetylcholine release2011

    • Author(s)
      Zhi-hong Lu, Satoru Fukuda, AtsushiYasuda, Hidetoshi Sakamoto, Shigeho Morita
    • Organizer
      日本麻酔科学会第58回学術集会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-22591718
  • [Presentation] Sleep arousal disorder after hypothalamic infarction in rats.2008

    • Author(s)
      Ogura M, Fukuda S, Gamou S, Sakamoto H, Morita S
    • Organizer
      2008 Annual Meeting of American Society of Anesthesiologists
    • Place of Presentation
      Orlando, FL, USA
    • Year and Date
      2008-10-20
    • Data Source
      KAKENHI-PROJECT-18390427
  • [Presentation] ラット中大脳動脈閉塞・再濯流によるオレキシン細胞壊死2008

    • Author(s)
      小倉舞, 福田 悟, 他
    • Organizer
      日本麻酔科学会第56回学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2008-06-12
    • Data Source
      KAKENHI-PROJECT-18390427
  • [Presentation] Sleep arousal disorder after hypothalamic infarction in rats2008

    • Author(s)
      Ogura M, Fukuda S, et al
    • Organizer
      2008 Annual Meeting of American Society of Anesthesiologists
    • Place of Presentation
      Orlando, FL, USA
    • Year and Date
      2008-10-20
    • Data Source
      KAKENHI-PROJECT-18390427
  • [Presentation] ラット中大脳動脈閉塞・再灌流によるオレキシン細胞壊死2008

    • Author(s)
      小倉 舞、蒲生早苗、坂本英俊、福田 悟、森田茂穂
    • Organizer
      日本麻酔科学会第56回学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2008-06-12
    • Data Source
      KAKENHI-PROJECT-18390427
  • [Presentation] ラットの一過性脳虚血後において、脳のペナンブラ領域にHMGB1 蛋白が早期に集積される2007

    • Author(s)
      坂本英俊、黒木佳奈子 桑名幸治 高橋隆一郎、福田 悟、森田茂穂
    • Organizer
      日本麻酔科学会第54回学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2007-05-31
    • Data Source
      KAKENHI-PROJECT-18390427
  • [Presentation] 脳梗塞後の睡眠覚醒障害 - ラット深部脳虚血モデルにおける検討-2007

    • Author(s)
      小倉 舞、蒲生早苗、吉田淳子、福田 悟、森田茂穂
    • Organizer
      日本麻酔科学会第54回学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2007-05-31
    • Data Source
      KAKENHI-PROJECT-18390427
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