KOIKE Kazuo 小池一男

Researcher Number	30130363
Affiliation (based on the past Project Information) *help	2012 – 2020: 東邦大学, 薬学部, 教授
Review Section/Research Field	Principal Investigator Basic Section 47050:Environmental and natural pharmaceutical resources-related / Natural medicines / Chemical pharmacy
Keywords	Principal Investigator 漢方薬 / 駆お血剤 / 抗酸化 / BPSD / 認知症 / aldose reductase / AGEs / プロティンチロシンホスファターゼ1B / 抗酸化活性 / 糖尿病 … More / 通導散 / 治打撲一方 / 大柴胡湯 / 抗酸化作用 / 麻子仁丸 / 糖代謝異常疾患 / 医療用漢方製剤 / 薬学 / サポニン / ヤブコウジ / 創薬 / 天然物 / 抗がん剤 Less

Study on effectiveness of Kampo medicines for "negative" surrounding symptoms of dementiaPrincipal Investigator
- Principal Investigator
  
  KOIKE Kazuo
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47050:Environmental and natural pharmaceutical resources-related
- Research Institution
  Toho University
Evaluation of Kampo Prescriptions as Therapeutic Agents for Glucose Metabolism DisordersPrincipal Investigator
- Principal Investigator
  
  KOIKE Kazuo
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Natural medicines
- Research Institution
  Toho University
Investigation of triterpenoid saponins from Ardisia plants with selective anti-proliferative activities against liver cancer cellsPrincipal Investigator
- Principal Investigator
  
  KOIKE Kazuo
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Toho University

All 2020 2019 2018 2017 2016 2014 2012 Other

All Journal Article Presentation

[Journal Article] Effects of Oral Administration of Low Dose Estrogen-Progestin on Mice and Combined Effect of Kampo Medicine2020
- Author(s)
  Asako Okamura, Kouharu Otsuki, Haruka Wada, Reiko Yokosawa, Eriko Nakadai, Kana Sekiguchi, Wei Li, Kazuo Koike
- Journal Title
  
  応用薬理
  
  Volume: 99 Pages: 89-98
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06724
[Journal Article] Identification and evaluation of magnolol and chrysophanol as the principle protein tyrosine phosphatase-1B inhibitory compounds in a Kampo medicine, Masiningan2016
- Author(s)
  Toshihisa Onoda, Wei Li, Tatsunori Sasaki, Megumi Miyake, Koji Higai, Kazuo Koike
- Journal Title
  
  Journal of Ethnopharmacology
  
  Volume: 186 Pages: 84-90
- DOI
  10.1016/j.jep.2016.03.063
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K08003
[Journal Article] Cyclamin, a natural 13,28-epoxy triterpenoid saponin, synergistically enhances cytotoxicity of chemotherapeutic drugs in human liver cancer cells but not non-neoplastic liver cells2014
- Author(s)
  Qin Li, Lin Deng, Wei Li, Kazuo Koike
- Journal Title
  
  Planta Medica
  
  Volume: ８０ Issue: 05 Pages: 409-414
- DOI
  10.1055/s-0034-1368198
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590027
[Journal Article] 13,28-Epoxy triterpenoid saponins from Ardisia japonica selectively inhibit proliferation of liver cancer cells without affecting normal liver cells2012
- Author(s)
  Qin Li, Wei Li, Lin-Ping Hui, Chen-Yang Zhao, Lin He, Kazuo Koike
- Journal Title
  
  Bioorganic & medicinal chemistry letters
  
  Volume: 22 Issue: 19 Pages: 6120-6125
- DOI
  10.1016/j.bmcl.2012.08.027
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590027
[Presentation] 通導散及びその構成生薬の抗酸化活性の検討2019
- Author(s)
  竹元裕明、東福真理菜、堀内まなみ、籏理英、佐藤直子、李巍、小池一男
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-18K06724
[Presentation] 医療用漢方製剤のin vivo抗酸化作用2018
- Author(s)
  竹元裕明、中村愛、徳倉絵美、佐藤直子、李巍、小池一男
- Organizer
  日本生薬学会第65年会
- Data Source
  KAKENHI-PROJECT-18K06724
[Presentation] 四塩化炭素誘発急性肝障害モデルマウスにおける大柴胡湯及び治打撲一方の抗酸化作用の評価2017
- Author(s)
  小松加奈、栗山典子、李巍、小池一男
- Organizer
  日本生薬学会第64回年会（千葉）
- Data Source
  KAKENHI-PROJECT-15K08003
[Presentation] 医療用漢方製剤147処方の抗酸化活性に関する研究2016
- Author(s)
  竹内未央、佐藤直子、小野田稔久、桧貝孝慈、李巍、小池一男
- Organizer
  日本生薬学会第63回年会
- Place of Presentation
  富山国際会議場（富山県・富山市）
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-15K08003
[Presentation] ヤブコウジ由来の13,28-エポキシトリテルペノイドサポニンの肝がん細胞毒性について
- Author(s)
  李巍, 小池一男, Li Qin
- Organizer
  日本生薬学会第59回年会
- Place of Presentation
  かずさアカデミアパーク(千葉県)
- Data Source
  KAKENHI-PROJECT-24590027
[Presentation] ヒト肝がん細胞におけるアルジシアサポニンと化学療法剤の併用効果
- Author(s)
  李巍, Li Qin,小池一男
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本大学黒髪キャンパス（熊本県熊本市）
- Data Source
  KAKENHI-PROJECT-24590027
[Presentation] 13,28-Epoxy triterpenoid saponins from Ardisia japonica and their selective antiproliferative activity on human liver cancer cells
- Author(s)
  Wei Li, Qin Li, Kazuo Koike
- Organizer
  The 7th KSP-JSP-CCTCNM Joint Symposium on Pharmacognosy
- Place of Presentation
  韓国ソウル
- Data Source
  KAKENHI-PROJECT-24590027
[Presentation] ヤブコウジ属薬用植物のトリテルペノイドサポニン成分解析および選択的肝がん細胞毒性
- Author(s)
  李巍, Li Qin, 馬玲, 小池一男
- Organizer
  第１９回天然薬物の開発と応用シンポジウム
- Place of Presentation
  大阪大学会館(大阪府)
- Data Source
  KAKENHI-PROJECT-24590027
[Presentation] LC-MS分析を活用したマンリョウArdisia crenata根の新規微量トリテルペノイドサポニンの探索研究
- Author(s)
  劉洋華, 李巍, 匡薪竹,馬玲,小池一男
- Organizer
  日本薬学会第133年会
- Place of Presentation
  パシフィコ横浜(神奈川県)
- Data Source
  KAKENHI-PROJECT-24590027

1. LI Wei (90328633)

# of Collaborated Projects: 3 results

# of Collaborated Products: 13 results

KOIKE Kazuo 小池 一男

Research Projects

Research Products

Co-Researchers

Study on effectiveness of Kampo medicines for "negative" surrounding symptoms of dementiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Evaluation of Kampo Prescriptions as Therapeutic Agents for Glucose Metabolism DisordersPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation of triterpenoid saponins from Ardisia plants with selective anti-proliferative activities against liver cancer cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Effects of Oral Administration of Low Dose Estrogen-Progestin on Mice and Combined Effect of Kampo Medicine2020

Author(s)

Journal Title

Data Source

[Journal Article] Identification and evaluation of magnolol and chrysophanol as the principle protein tyrosine phosphatase-1B inhibitory compounds in a Kampo medicine, Masiningan2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cyclamin, a natural 13,28-epoxy triterpenoid saponin, synergistically enhances cytotoxicity of chemotherapeutic drugs in human liver cancer cells but not non-neoplastic liver cells2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 13,28-Epoxy triterpenoid saponins from Ardisia japonica selectively inhibit proliferation of liver cancer cells without affecting normal liver cells2012

Author(s)

Journal Title

DOI

Data Source

[Presentation] 通導散及びその構成生薬の抗酸化活性の検討2019

Author(s)

Organizer

Data Source

[Presentation] 医療用漢方製剤のin vivo抗酸化作用2018

Author(s)

Organizer

Data Source

[Presentation] 四塩化炭素誘発急性肝障害モデルマウスにおける大柴胡湯及び治打撲一方の抗酸化作用の評価2017

Author(s)

Organizer

Data Source

[Presentation] 医療用漢方製剤147処方の抗酸化活性に関する研究2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] ヤブコウジ由来の13,28-エポキシトリテルペノイドサポニンの肝がん細胞毒性について

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] ヒト肝がん細胞におけるアルジシアサポニンと化学療法剤の併用効果

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] 13,28-Epoxy triterpenoid saponins from Ardisia japonica and their selective antiproliferative activity on human liver cancer cells

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] ヤブコウジ属薬用植物のトリテルペノイドサポニン成分解析および選択的肝がん細胞毒性

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] LC-MS分析を活用したマンリョウArdisia crenata根の新規微量トリテルペノイドサポニンの探索研究

KOIKE Kazuo 小池一男