YAMAGUCHI Tokio 山口登喜夫

… Alternative Names

山口登喜夫ヤマグチトキオ

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Researcher Number	30134745
Other IDs
Affiliation (based on the past Project Information) *help	2009 – 2011: 東京医科歯科大学, 難治疾患研究所, 准教授 2007: 東京医科歯科大学, 難治疾患研究所, 助教授 2003: Tokyo Dent.Med.Univ., associate professor, 難知疾患研究所, 助教授 1993 – 2003: 東京医科歯科大学, 難治疾患研究所, 助教授 1996 – 1997: 東京医科歯科大学, 難治疾患研究所・遺伝疾患(遺伝生化), 助教授 1996: Tokyo Medical Research Institute, Tokyo Medical and Dental University Asscciate, 難治研, 助教授 1990 – 1991: 東京医科歯科大学, 難治研, 助教授
Review Section/Research Field	Principal Investigator Pathological medical chemistry / 内科学一般 / Embryonic/Neonatal medicine Except Principal Investigator Fisheries chemistry / Digestive surgery / Obstetrics and gynecology / General surgery / 食品科学・栄養科学 / General surgery / Fisheries chemistry / Laboratory medicine
Keywords	Principal Investigator bilirubin / ビリルビン / antioxidant / 酸化的ストレス / ビリベルジン / バイオピリン / oxidative stress / 抗酸化剤 / oxidative stress-marker / biopyrrin … More / Home oxygenase / Psychological stress / Oxidative stress / Antioxidant / Biopyrrin / Bilirubin oxidative metabolites / Biliverdin / Bilirubin / 酸化ストレス / ヘム代謝 / ストレス・マーカー / ビリルビン酸化生成物 / 酸化ストレス・マーカー / アンチオキシダント / mitochondria / stercobilin / urobilin / biliverdin / neuron / apoptosis / kernicterus / ミトコンドリア / ステルコビリン / ウロビリン / ニューロン / アポトーシス / 核黄疸 / ascorbic acid / endotoxin / heme oxygenase / ELISA / ビソベルジン … More Except Principal Investigator ビリルビン / Bilirubin / 黄疸 / bilirubin / Jaundice / 活性酸素 / 酸化ストレス / バイオピリン / 尿 / 抗酸化剤 / oxidative stress / sepsis / 敗血症 / ヘムオキシゲナーゼ / Fish Meal / Extruder Treatment / Ascorbic Acid / Substance X / Yellowtail / 魚粉 / アスコルビン酸 / α-トコフェロール / サブスタンスX / ブリ / 生体内脂質過酸化 / 8-hydroxy deoxyguanosine / acrolein / lipid peroxides / biopyrrin / jaundice / hyperbaric oxygen / superoxide / 高圧酸素療法 / 8水酸化デオキシグアノシン / アクロレイン / 過酸化脂質 / 黄疽 / 高圧酸素 / complication / surgery / severity / urine / antioxidant / 合併症 / 外科手術 / 重症度 / Fenton reaction / calcium ion / prostaglandin / death / granulosa cells / atresia / LHレセプター / トランスフェリン / アポトーシス / アトレジア / フェントン反応 / カルシウムイオン / 細胞死 / プロスタグランジン / 顆粒膜細胞 / heme oxygenase / intestine / 小腸 / alpha-Tocopherol / エクストルーダー処理 / Oxidative stress / Ascorbic acid / インスリン依存性糖尿病 / 抗酸化物質 / ビタミンC / 酸化的ストレス / alpha-Tocoperol / グルタチオンペルオキシダーゼ / alpha-トコフェロール / エクストル-ダ処理 / Bile pigments / Antioxidant / Brown fish meal / In vivo lipid peroxidation / Anti-bilirubin monoclonal anitibody / alpha-Tocoherol / 胆汁色素 / 抗酸化機能 / ブラウンフィッシュミ-ル / 抗ビリルビンモノクロ-ナル抗体 / αートコフェロ-ル / 黄疳 / 抗酸化治療 / 窒素ラジカル / 酸化ビリルビン / SIRS / 全身性炎症反応症候群 / 外科総論 / 天然物化学 / 24G7抗体 / 急性拒絶反応 / 腎移植 / 心移植 / イムノクロマトグラフィー Less

海洋深層水中のCOX‐I抑制物質の探索
- Principal Investigator
  
  笹栗志朗
- Project Period (FY)
  2009
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Fisheries chemistry
- Research Institution
  Kochi University
The examination of oxidative stress under systemic inflammatory response syndrome evaluated by oxidative bilirubin.
- Principal Investigator
  
  OKADA Hironobu
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Kochi University
特異的24G7抗体イムノクロマトグラフィーによる急性拒絶反応の新しい診断法の確立
- Principal Investigator
  
  SASAGURI Shiro
- Project Period (FY)
  2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Laboratory medicine
- Research Institution
  Kochi University
Use of urinary bilirubin oxidative metabolites as a psychological stress-marker.Principal Investigator
- Principal Investigator
  
  YAMAGUCHI Tokio
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  内科学一般
- Research Institution
  Tokyo medical and dental university, Medical Research Institute
Effect of hyperbaric oxygen on hyperbiliri.ibinemia from the viewpoint of antioxidant activity of bilirubin
- Principal Investigator
  
  SHIMIZU Shuji
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyushu University
Increased urinary excretion of bilirubin oxidative metabolites in septic patients: a new marker for ocidative stress in vivo
- Principal Investigator
  
  SHIMIZU Shuji
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  KYUSHU UNIVERSITY
Neuron dysfunction in bilirubin-induced apoptosis causes kernicterusPrincipal Investigator
- Principal Investigator
  
  YAMAGUCHI Tokio
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Embryonic/Neonatal medicine
- Research Institution
  Tokyo Medical and Dental University, Medical Research Institute
Cell death and luteinization of ovarian granulosa cells
- Principal Investigator
  
  ASAKAI Rei
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Tokyo Medical and Dental University
Clinical application of a biodefense reaction against oxidative stress using mAb.Principal Investigator
- Principal Investigator
  
  YAMAGUCHI Tokio
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Tokyo medical and dental university, Medical Research Institute
The induction of heme oxygenese-1 in intestinal mucosa of septic rat
- Principal Investigator
  
  SHIMIZU Shuji
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Kyushu University
Bilirubin as a biodefense factor against oxidative stress and its clinical applicationPrincipal Investigator
- Principal Investigator
  
  YAMAGUCHI Tokio
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Tokyo medical and dental university, Medical Research Institute
The roles of bilirubin and ascorbic acid as physiological antioxidant against oxidative stress.
- Principal Investigator
  
  HORIO Fumihiko
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  食品科学・栄養科学
- Research Institution
  Nagoya University
Studies on antioxidant activities of bilirubin and in vivo lipid peroxidation of fish.
- Principal Investigator
  
  SAKAI Tadashi
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Fisheries chemistry
- Research Institution
  Miyazaki University
Studies on bilirubin metabolism and in vivo lipid peroxidation of fish.
- Principal Investigator
  
  SAKAI Tadashi
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Fisheries chemistry
- Research Institution
  Miyazaki University
Studies on bilirubin metabolism in fish
- Principal Investigator
  
  SAKAI Tadashi
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Fisheries chemistry
- Research Institution
  Miyazaki University

All 2004 2003 2002 Other

All Journal Article Book

[Book] スタンダード生化学2004
- Author(s)
  山口登喜夫(分担執筆)
- Total Pages
  12
- Publisher
  文光堂
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570409
[Journal Article] Induction of heme oxygenase-1 in monocytes suppresses angiotensine II-Elicited chemotactic activity through inhibition of CCR2 : role of bilirubin and carbon monoxide generated by the enzyme.2003
- Author(s)
  Morita, T., Imai, T., Yamaguchi, T., Sugiyama, t., Katayama, S., Yoshino, G.
- Journal Title
  
  Antioxidants & Redox Signaling 5(4)
  
  Pages: 439-447
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570409
[Journal Article] Heme oxygenase inhibits human airway smooth muscle proliferation via a bilirubin-dependent modulation of ERK1/2 phosphorilation.2003
- Author(s)
  Taille, C., Aimolki, A., Benhamed, M., Yamaguchi, T., Auber, M., Boczkowski, J.
- Journal Title
  
  J.Biol.Chem. 278
  
  Pages: 27160-27168
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570409
[Journal Article] Urinary excretion of oxidative metabolites of bilirubin in fenofibrate-treated rats2003
- Author(s)
  Kobayashi, A., Takahashi, T., Sugai, S., Miyakawa, Y., Iwatsuka, H., Yamaguchi, T.
- Journal Title
  
  J.Toxicological Science 28(2)
  
  Pages: 71-75
- NAID
  110001802891
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570409
[Journal Article] Psychological stress Increases bilirubin metabolites in human urine.2002
- Author(s)
  Yamaguchi, T., Shioji, I., Sugimoto, A., Yamaoka, M.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 293
  
  Pages: 517-520
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570409
[Journal Article] Leydig cells-derived heme oxygenase-1 regulates apoptosis of premeiotic germ cells in response to styress.2002
- Author(s)
  Ozawa, N., Goda, N., Makino, N., Yamaguchi, T., Yoshimura, Y., Suematsu, M.
- Journal Title
  
  J.Clin.Invest. 109(4)
  
  Pages: 457-467
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570409
[Journal Article] Azidothimidine caused functional and structural destruction of mitochondria, glutathlone deficiency and HIV-1 promoter sencsitization.2002
- Author(s)
  Yamaguchi, T., Katoh, I., Kurata, S.
- Journal Title
  
  Eur.J.Biochem. 269
  
  Pages: 2782-2788
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570409
[Journal Article] Psychological stress increases bilirubin metabolites in human urine.2002
- Author(s)
  Yamaguchi, T., et al.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 293
  
  Pages: 517-520
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570409
[Journal Article] Azidothimidine causes functional and structural destration of mitochondria, glutth
- Author(s)
  Yamaguchi, T., et al.
- Journal Title
  
  Eur.J.Biochem. 269
  
  Pages: 2782-2788
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570409

1. KUROKI Syoji (30215090)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. SASAGURI Shiro (60196186)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. SAKAI Tadashi (60136794)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. MURATA Hisashi (60041018)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. HORIO Fumihiko (20165591)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. SUGIMOTO Akiko (60143608)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
7. SHIMIZU Shuji (70274454)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
8. YAMAGUCHI Koji (50191226)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
9. CHIJIIWA Kazuo (90179945)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
10. ASAKA Rei (20167224)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. MAEDA Hironori (20335946)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. SUEMATSU Makoto (00206385)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
13. OKADA Hironobu (10444770)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. YAMAMOTO Masaki (20437718)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. SAITO Fumiko (10158917)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 宋時栄 (00399693)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 小川浩史 (50260518)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. YAMAOKA Masayuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results

YAMAGUCHI Tokio 山口 登喜夫

山口 登喜夫 ヤマグチ トキオ

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Use of urinary bilirubin oxidative metabolites as a psychological stress-marker.Principal Investigator

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Neuron dysfunction in bilirubin-induced apoptosis causes kernicterusPrincipal Investigator

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Clinical application of a biodefense reaction against oxidative stress using mAb.Principal Investigator

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Bilirubin as a biodefense factor against oxidative stress and its clinical applicationPrincipal Investigator

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YAMAGUCHI Tokio 山口登喜夫

山口登喜夫ヤマグチトキオ