AKASAKA Toshihide 赤坂俊英

Researcher Number	30137525
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2012 – 2015: 岩手医科大学, 医学部, 教授 2014: 岩手医科大学, 大学院医学研究科, 教授 1998 – 2000: 岩手医科大学, 医学部, 教授
Review Section/Research Field	Principal Investigator Dermatology Except Principal Investigator Human pathology / Experimental pathology
Keywords	Principal Investigator p125FAK / Endothelin-1 / Cell motility / Melanocyte / 正常色素細胞 / 樹枝状突起 / 細胞分化 / endothelin-1 / 細胞運動 / melanocyte / 細胞運動能 / 色素細胞 … More Except Principal Investigator … More 細胞老化 / 分裂死 / 分裂期崩壊 / アポトーシス / 分裂攪乱 / 悪性黒色腫 / 細胞分裂 / 遺伝子病理診断学 / 抗酸化関連分子 / 腫瘍 / lincRNA / 腫瘍化 / 非翻訳RNA Less

Mechanism for natural resistance of melanoma cells against anti-tubulin drugs
- Principal Investigator
  
  Yasuhira Shinji
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Iwate Medical University
Involvement of lincRNA in carcinogenesis
- Principal Investigator
  
  SHIBAZAKI Masahiko
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Iwate Medical University
Influence of endothelin to cell morphology of dendrites and cell motility in cultured normal human melanocytesPrincipal Investigator
- Principal Investigator
  
  AKASAKA Toshihide
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Iwate Medical University

All 2016 2014 2013 2012

All Journal Article Presentation

[Journal Article] NAD(P)H:Quinone Oxidoreductase-1 Expression Sensitizes Malignant Melanoma Cells to the HSP90 Inhibitor 17-AAG.2016
- Author(s)
  Kasai S, Arakawa N, Okubo A, Shigeeda W, Yasuhira S, Masuda T, Akasaka T, Shibazaki M, Maesawa C.
- Journal Title
  
  PLoS One.
  
  Volume: 11 Issue: 4 Pages: e0153181-e0153181
- DOI
  10.1371/journal.pone.0153181
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08353, KAKENHI-PROJECT-25460421, KAKENHI-PROJECT-25460462, KAKENHI-PROJECT-26860243
[Journal Article] NAD(P)H dehydrogenase, quinone 1 (NQO1), protects melanin-producing cells from cytotoxicity of rhododendrol.2016
- Author(s)
  Okubo A, Yasuhira S, Shibazaki M, Takahashi K, Akasaka T, Masuda T, Maesawa C.
- Journal Title
  
  Pigment Cell Melanoma Res.
  
  Volume: 29 Issue: 3 Pages: 309-16
- DOI
  10.1111/pcmr.12461
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08353, KAKENHI-PROJECT-25460421, KAKENHI-PROJECT-25460462
[Journal Article] A somatic mutation of the KEAP1 gene in malignant melanoma is involved in aberrant NRF2 activation and an increase in intrinsic drug resistance.2014
- Author(s)
  Miura S, Shibazaki M, Kasai S, Yasuhira S, Watanabe A, Inoue T, Kageshita Y, Tsunoda K, Takahashi K, Akasaka T, Masuda T, Maesawa C.
- Journal Title
  
  Journal of investigative dermatology
  
  Volume: 134 Pages: 553-556
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590489
[Journal Article] Immunohistochemistry for histone h3 lysine 9 methyltransferase and demethylase proteins in human melanomas.2014
- Author(s)
  Miura S, Maesawa C, Shibazaki M, Yasuhira S, Kasai S, Tsunoda K, Maeda F, Takahashi K, Akasaka T, Masuda T.
- Journal Title
  
  American journal of dermatopathology
  
  Volume: 36 Pages: 211-216
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590489
[Journal Article] Immunohistochemistry for histone h3 lysine 9 methyltransferase and demethylase proteins in human melanomas.2014
- Author(s)
  Miura S, Maesawa C, Shibazaki M, Yasuhira S, Kasai S, Tsunoda K, Maeda F, Takahashi K, Akasaka T, Masuda T. Immunohistochemistry for histone h3 lysine 9 methyltransferase and demethylase proteins in human melanomas.
- Journal Title
  
  Am J Dermatopathol
  
  Volume: 36(3) Issue: 3 Pages: 211-216
- DOI
  10.1097/dad.0b013e3182964e02
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23590431, KAKENHI-PROJECT-24590489, KAKENHI-PROJECT-24659283, KAKENHI-PROJECT-24791171, KAKENHI-PROJECT-25460421, KAKENHI-PROJECT-25460462, KAKENHI-PROJECT-25860964, KAKENHI-PROJECT-26860891
[Journal Article] BCL2 and BCLxL are key determinants of resistance to antitubulin chemotherapeutics in melanoma cells.2013
- Author(s)
  Watanabe A, Yasuhira S, Inoue T, Kasai S, Shibazaki M, Takahashi K, Akasaka T, Masuda T, Maesawa C.
- Journal Title
  
  Experimental dermatology
  
  Volume: 22 Pages: 518-523
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590489
[Journal Article] Transcriptional and post-transcriptional regulation of βIII-tubulin protein expression in relation with cell cycle-dependent regulation of tumor cells2012
- Author(s)
  Shibazaki M, Maesawa C, Akasaka K, Kasai S, Yasuhira S, Kanno K, Nakayama I, Sugiyama T, Wakabayasi G, Masuda T, Mori N
- Journal Title
  
  Int.J.Oncol.
  
  Volume: 40(3) Pages: 695-702
- DOI
  10.3892/ijo.2011.1291
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300121, KAKENHI-PROJECT-22390071, KAKENHI-PROJECT-24590489, KAKENHI-PROJECT-24790391, KAKENHI-PROJECT-24791171
[Journal Article] Downregulation of cylindromatosis gene, CYLD, confers a growth advantage on malignant melanoma cells while negatively regulating their migration activity2012
- Author(s)
  Ishikawa Y, Tsunoda K, Shibazaki M, Takahashi K, Akasaka T, Masuda T, Maesawa C.
- Journal Title
  
  Int J Oncol
  
  Volume: 41(1) Pages: 53-60
- DOI
  10.3892/ijo.2012.1424
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390071, KAKENHI-PROJECT-23590431, KAKENHI-PROJECT-23890198, KAKENHI-PROJECT-24590489
[Presentation] 悪性黒色腫における抗チューブリン剤耐性はBCL2とBCL-XLによって規定される2013
- Author(s)
  渡辺彩乃,安平進士,葛西秋宅,柴崎晶彦,赤坂俊英,増田友之,前沢千早
- Organizer
  第102回日本病理学会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-24590489
[Presentation] 悪性黒色腫細胞株の網羅的エクソーム解析による新規関連遺伝子の検索2013
- Author(s)
  柴崎晶彦,三浦慎平,安平進士,葛西秋宅,赤坂俊英,増田友之,前沢千早
- Organizer
  第102回日本病理学会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-24590489
[Presentation] 悪性黒色腫におけるヒストンメチル化酸素、脱ヒストンメチル化酸素の発現の検討2013
- Author(s)
  影下雄一,前沢千早,三浦慎平,柴崎晶彦,安平進士,葛西秋宅,角田加奈子,前田文彦,高橋和宏,赤坂俊英,増田友之
- Organizer
  第102回日本病理学会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-24590489
[Presentation] 悪性黒色腫における抗チューブリン剤耐性はBCL2とBCL-XLによって規定される2012
- Author(s)
  渡辺彩乃,安平進士,葛西秋宅,柴崎晶彦,赤坂俊英,増田友之,前沢千早
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24590489
[Presentation] 悪性黒色腫においてCYLD遺伝子は増殖能獲得に関与するが運動能は抑制する2012
- Author(s)
  石川雄一,前沢千早,角田加奈子,柴崎晶彦,赤坂俊英,増田友之
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-24590489
[Presentation] 悪性黒色腫細胞株の網羅的エクソーム解析による新規関連遺伝子の検索2012
- Author(s)
  柴崎晶彦,三浦慎平,安平進士,葛西秋宅,赤坂俊英,増田友之,前沢千早
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24590489

1. MAESAWA Chihaya (10326647)

# of Collaborated Projects: 2 results

# of Collaborated Products: 13 results
2. SUGIYAMA Toru (40162903)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. SHIBAZAKI Masahiko (20445109)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
4. KASHIWABA Masahiro (80326660)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. Yasuhira Shinji (90311729)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. MORI Yasuki (40244925)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 森望

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 増田友之

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results

AKASAKA Toshihide 赤坂 俊英

Research Projects

Research Products

Co-Researchers

Mechanism for natural resistance of melanoma cells against anti-tubulin drugs

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Involvement of lincRNA in carcinogenesis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Influence of endothelin to cell morphology of dendrites and cell motility in cultured normal human melanocytesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] NAD(P)H:Quinone Oxidoreductase-1 Expression Sensitizes Malignant Melanoma Cells to the HSP90 Inhibitor 17-AAG.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] NAD(P)H dehydrogenase, quinone 1 (NQO1), protects melanin-producing cells from cytotoxicity of rhododendrol.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A somatic mutation of the KEAP1 gene in malignant melanoma is involved in aberrant NRF2 activation and an increase in intrinsic drug resistance.2014

Author(s)

Journal Title

Data Source

[Journal Article] Immunohistochemistry for histone h3 lysine 9 methyltransferase and demethylase proteins in human melanomas.2014

Author(s)

Journal Title

Data Source

[Journal Article] Immunohistochemistry for histone h3 lysine 9 methyltransferase and demethylase proteins in human melanomas.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] BCL2 and BCLxL are key determinants of resistance to antitubulin chemotherapeutics in melanoma cells.2013

Author(s)

Journal Title

Data Source

[Journal Article] Transcriptional and post-transcriptional regulation of βIII-tubulin protein expression in relation with cell cycle-dependent regulation of tumor cells2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Downregulation of cylindromatosis gene, CYLD, confers a growth advantage on malignant melanoma cells while negatively regulating their migration activity2012

Author(s)

Journal Title

DOI

Data Source

[Presentation] 悪性黒色腫における抗チューブリン剤耐性はBCL2とBCL-XLによって規定される2013

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] 悪性黒色腫細胞株の網羅的エクソーム解析による新規関連遺伝子の検索2013

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] 悪性黒色腫におけるヒストンメチル化酸素、脱ヒストンメチル化酸素の発現の検討2013

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] 悪性黒色腫における抗チューブリン剤耐性はBCL2とBCL-XLによって規定される2012

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] 悪性黒色腫においてCYLD遺伝子は増殖能獲得に関与するが運動能は抑制する2012

AKASAKA Toshihide 赤坂俊英