MISHIMA Yukio 三嶋行雄

Researcher Number	30142029
Affiliation (based on the past Project Information) *help	2010 – 2015: 新潟大学, 医歯学系, 准教授
Review Section/Research Field	Principal Investigator Functional basic dentistry Except Principal Investigator Risk sciences of radiation and chemicals / Risk sciences of radiation/Chemicals
Keywords	Principal Investigator 腸管組織肥厚 / 転写制御 / βカテニン / p57遺伝子 / p27遺伝子 / Bck11b / Lucレポーターアッセイ / Mdm2 / がん抑制因子 / 発現制御 … More / Ｍｄｍ2/HDM2 / p53 / Bcl11b / がん抑制遺伝子 / シグナル伝達 / Mdm2/HDM2 / p^53 / 転写因子Bcl11b/BCL11B / 腸管組織の肥厚 / 過剰歯形成 … More Except Principal Investigator DNAチップ解析 / グリセロール密度勾配遠心法 / SWI/SNIF複合体 / がん抑制因子 / p53-MDM2フィードバックループ / 放射線応答 / SWI/SNF複合体 / がん抑制遺伝子 / BCL11B / 腸管腫瘍 / 細胞の増殖と消失 / 発がん母細胞 / 放射線標的細胞 / Bcl11ｂ / Bcl11b / 胸腺リンパ腫 / 大腸がん / 幹細胞 / 発がん / 電離放射線 Less

Effect of BCL11B and its mutations on the radiation response: analysis of a p53-MDM2 feed-back loop
- Principal Investigator
  
  OBATA Miki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Risk sciences of radiation and chemicals
- Research Institution
  Niigata University
Radiation target and mutagenesis in intestinal tumors
- Principal Investigator
  
  KOMINAMI Ryo
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  Niigata University
Analysis of mouse teeth hyperplasia and gut tissue enlargement by mutation of transcription factor Bcl11bPrincipal Investigator
- Principal Investigator
  
  MISHIMA Yukio
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Niigata University

All 2015 2014 2013 2012 2011 2010 Other

All Journal Article Presentation

[Journal Article] Bcl11b SWI/SNF-complex subunit modulates intestinal adenoma and regeneration after γ-irradiation through Wnt/β-catenin pathway.2015
- Author(s)
  Sakamaki A, Katsuragi Y, Otsuka K, Tomita M, Obata M, Iwasaki T, Abe M, Sato T, Ochiai M, Sakuraba Y, Aoyagi Y, Gondo Y, Sakimura K, Nakagama H, Mishima Y, Kominami R
- Journal Title
  
  Carcinogenesis
  
  Volume: 36 Issue: 6 Pages: 622-631
- DOI
  10.1093/carcin/bgv044
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25241016, KAKENHI-PROJECT-25340027
[Journal Article] Human T-cell leukemia virus type 1 Tax oncoprotein represses the expression of the BCL11B tumor suppressor in T-cells2015
- Author(s)
  Takachi T, Takahashi M, Takahashi-Yoshita M, Higuchi M, Obata M, Mishima Y, Okuda S, Tanaka Y, Matsuoka M, Saitoh A, Green PL, Fujii M.
- Journal Title
  
  Cance Science
  
  Volume: 106(4) Issue: 4 Pages: 461-465
- DOI
  10.1111/cas.12618
- NAID
  120006844098
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26670222, KAKENHI-PROJECT-221S0001, KAKENHI-PROJECT-26461417, KAKENHI-PROJECT-15H04704, KAKENHI-PROJECT-25340027, KAKENHI-PROJECT-26242088
[Journal Article] Successful management of severe intrahepatic cholestasis of pregnancy: report of a first Japanese case.2014
- Author(s)
  Kamimura K, Abe H, Kamimura N, Yamaguchi M, Mamizu M, Ogi K, Takahashi Y, Mizuno K, Kamimura H, Kobayashi Y, Takeuchi M, Yoshida K, Yamada K, Enomoto T, Takakuwa K, Nomoto M, Obata M, Katsuragi Y, Mishima Y, Kominami R, Kamimura T, Aoyagi Y.
- Journal Title
  
  BMC Gastroenterol.
  
  Volume: 14 Issue: 1 Pages: 160-4
- DOI
  10.1186/1471-230x-14-160
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25340027
[Journal Article] Bcl11b transcription factor plays a role in the maintenance of the ameloblast-progenitors in mouse adult maxillary incisors2013
- Author(s)
  Katsuragi Y, Anraku J, Nakatomi M, Ida-Yonemochi H, Obata M, Mishima Y, Sakuraba Y, Gondo Y, Kodama Y, Nishikawa A, Takagi R, Ohshima H, Kominami R
- Journal Title
  
  Mech Dev
  
  Volume: 130 Pages: 482-492
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310036
[Journal Article] Cell of origin in radiation-induced premalignant thymocytes in mice conditionally losing one Bcl11b allele2013
- Author(s)
  Go R, Hirose S, Katsuragi Y, Obata M, Abe M, Mishima Y, Sakimura K, Kominami R
- Journal Title
  
  Cancer Sci
  
  Volume: 104 Pages: 1009-1016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310036
[Journal Article] Cell of origin in radiation-induced premalignant thymocytes in mice conditionally losing one Bcl11b allele.2013
- Author(s)
  Go R, Hirose S, Katsuragi Y, Obata M, Abe M, Mishima Y, Sakimura K, Kominami R.
- Journal Title
  
  Cancer Science
  
  Volume: 104 Issue: 8 Pages: 1009-1016
- DOI
  10.1111/cas.12193
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310036, KAKENHI-PROJECT-23710067, KAKENHI-PROJECT-23792100, KAKENHI-PROJECT-24700321, KAKENHI-PROJECT-24790465, KAKENHI-PROJECT-25340027
[Journal Article] Bcl11b transcription factor plays a role in the maintenance of the ameloblast-progenitors in mouse adult maxillary incisors.2013
- Author(s)
  Katsuragi Y, Anraku J, Nakatomi M, Ida-Yonemochi H, Obata M, Mishima Y, Sakuraba Y, Gondo Y, Kodama Y, Nishikawa A, Takagi R, Ohshima H, Kominami R.
- Journal Title
  
  Mechanism and Development
  
  Volume: 130 Issue: 9-10 Pages: 482-492
- DOI
  10.1016/j.mod.2013.05.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310036, KAKENHI-PROJECT-23593026, KAKENHI-PROJECT-23792100, KAKENHI-PROJECT-24659810, KAKENHI-PROJECT-25241016, KAKENHI-PROJECT-25340027
[Journal Article] Impairment in differentiation and cell cycle of thymocytes by loss of a Bcl11b tumor suppressor allele that contributes to leukemogenesis2012
- Author(s)
  Go, R, Takizawa, K, Hirose, S, Katsuragi, Y, Aoyagi, Y, Mishima, Y, and Kominami, R
- Journal Title
  
  Leuk Res
  
  Volume: 36 Pages: 1035-1040
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310036
[Journal Article] BCL11B tumor suppressor inhibits HDM2 expression in a p^53-dependent manner2012
- Author(s)
  M. Obata, R. Kominami and Y. Mishima
- Journal Title
  
  Cellular Signalling
  
  Volume: 24 Issue: 5 Pages: 1047-1052
- DOI
  10.1016/j.cellsig.2011.12.026
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22592062
[Journal Article] BCL11B tumor suppressor inhibits HDM2 expression in a p53-dependent manner2012
- Author(s)
  Obata M, Kominami R, Mishima Y
- Journal Title
  
  Cell Signal
  
  Volume: 24 Pages: 1047-52
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310036
[Journal Article] Impairment in differentiation and cell cycle of thymocytes by loss of a Bcl11b tumor suppressor allele that contributes to leukemogenesis2012
- Author(s)
  R. Go, K. Takizawa, S. Hirose, Y. Katsuragi,Y. Aoyagi, S, Y. Mishima and R. Kominami
- Journal Title
  
  Leukemia Research
  
  Volume: 36 Issue: 8 Pages: 1035-1040
- DOI
  10.1016/j.leukres.2012.04.028
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22592062, KAKENHI-PROJECT-23659395, KAKENHI-PROJECT-23710067, KAKENHI-PROJECT-23792100, KAKENHI-PROJECT-24790465
[Journal Article] Bcl11b heterozygosity leads to age-related hearing loss and degeneration of outer hair cells of the mouse cochlea2011
- Author(s)
  H. Okumura, Y. Miyasaka, Y. Morita, T. Nomura, Y. Mishima, S. Takahashi and R. Kominami
- Journal Title
  
  Experimental Animals
  
  Volume: 60 Pages: 355-361
- NAID
  10029550638
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22592062
[Journal Article] Bcl11b heterozygosity leads to age-related hearing loss and degeneration of outer hair cells of the mouse cochlea2011
- Author(s)
  Okumura H, Miyasaka Y, Morita Y, Nomura T, Mishima Y, Takahashi S, Kominami R
- Journal Title
  
  Exp Anim
  
  Volume: 60 Pages: 355-61
- NAID
  10029550638
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310036
[Journal Article] Clonally expanding thymocytes having lineage capability in γ-ray induced mouse atrophic thymus2010
- Author(s)
  T. Yamamoto, S. Morita, E. Go, M. Obata, Y. Katsuragi, Y. Fujita, Y. Maeda, M. Yokoyama, Y. Aoyagi, H. Ichikawa, Y. Mishima and R. Kominami
- Journal Title
  
  International Journal of Radiation Oncology. Biology. Physics
  
  Volume: 77 Issue: 1 Pages: 235-243
- DOI
  10.1016/j.ijrobp.2009.11.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22592062
[Journal Article] Bcl11b heterozygousity promotes clonal expansion and differentiation arrest of thymocytes in γ-irradiated mice2010
- Author(s)
  R. Go, S. Hirose, S. Morita, T. Yamamoto, Y. Katsuragi, Y. Mishima and R. Kominami
- Journal Title
  
  Cancer Science
  
  Volume: 101 Issue: 6 Pages: 1347-1353
- DOI
  10.1111/j.1349-7006.2010.01546.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22592062
[Journal Article] Cell of origin in radiation-induced premalignant thymocytes with differentiation capability in mice conditionally losing one Bcl11b allele
- Author(s)
  R. Go, S. Hirose, Y. Katsuragi, M. Obata, M. Abe, Y. Mishima, K. Sakimura and R.Kominami
- Journal Title
  
  Cancer Science
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22592062
[Presentation] 転写因子BCL11Bはp53を介して細胞周期を調節する？2013
- Author(s)
  小幡　美貴　・　木南　凌　・　三嶋　行雄
- Organizer
  第56回日本放射線影響学会大会
- Place of Presentation
  ホテルクラウンパレス青森　(青森市)
- Data Source
  KAKENHI-PROJECT-25340027
[Presentation] 放射線発がんにおける発がん母細胞と標的細胞2013
- Author(s)
  木南凌, 郷梨江香, 葛城美徳, 小幡美貴, 三嶋行雄
- Organizer
  第55回大会日本放射線影響学会
- Place of Presentation
  青森市
- Year and Date
  2013-10-18
- Data Source
  KAKENHI-PROJECT-23310036
[Presentation] BCL11B mutations identified in T-ALL leukemias negatively or positively affect the activity of SWI/SNF chromatin remodeling complexes2013
- Author(s)
  小幡　美貴　・　木南　凌　・　三嶋　行雄
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド　(神戸市)
- Data Source
  KAKENHI-PROJECT-25340027
[Presentation] 放射線発がんにおける発がん母細胞と標的細胞2013
- Author(s)
  木南凌、郷梨江香、葛城美徳、小幡美貴、三嶋行雄
- Organizer
  日本放射線影響学会
- Place of Presentation
  青森
- Invited
- Data Source
  KAKENHI-PROJECT-23310036
[Presentation] ヒトT細胞急性リンパ芽球性白血病で見いだされたBCL11B突然変異はp53依存性にHDM2プロモーター活性の抑制効果を阻害する2012
- Author(s)
  小幡美貴、木南凌、三嶋行雄
- Organizer
  第35回日本分子生物学会年
- Place of Presentation
  福岡
- Year and Date
  2012-12-13
- Data Source
  KAKENHI-PROJECT-22592062
[Presentation] 放射線照射後の腸上皮におけるBcl11bの働き2012
- Author(s)
  葛城美徳、坂牧僚、小幡美貴、三嶋行雄、大塚健介、木南凌
- Organizer
  第55回日本放射線影響学会
- Place of Presentation
  仙台
- Year and Date
  2012-09-07
- Data Source
  KAKENHI-PROJECT-22592062
[Presentation] 転写因子Bcl11bはマウス上顎切歯におけるエナメル芽細胞前駆細胞の恒常性に寄与する2012
- Author(s)
  葛城美徳、安楽純子、中富満城、依田浩子、三嶋行雄、櫻庭喜行、権藤洋一、高木律男、大島勇人、木南凌
- Organizer
  第35回日本分子生物学会年
- Place of Presentation
  福岡
- Year and Date
  2012-12-12
- Data Source
  KAKENHI-PROJECT-22592062
[Presentation] Bcl11bの片アリル欠損はγ線照射後のマウス小腸上皮幹細胞の増殖を促進する2011
- Author(s)
  葛城美徳、坂牧僚、小幡美貴、三嶋行雄、木南凌
- Organizer
  第54回日本放射線影響学会大会
- Place of Presentation
  神戸
- Year and Date
  2011-11-17
- Data Source
  KAKENHI-PROJECT-22592062
[Presentation] 転写因子Bcl11bはp^53経路を介して細胞増殖を抑制する2011
- Author(s)
  小幡美貴、坂牧僚、木南凌、三嶋行雄
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都
- Year and Date
  2011-09-23
- Data Source
  KAKENHI-PROJECT-22592062
[Presentation] BCL11B inhibits HDM2 expression in a p^53-denpendent manner2011
- Author(s)
  小幡美貴、木南凌、三嶋行雄
- Organizer
  第34回日本分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2011-12-16
- Data Source
  KAKENHI-PROJECT-22592062
[Presentation] Bcl11b transcription factor controls the formation and maintenance of ameloblast-lineage cells in mouse adult maxillary incisor2011
- Author(s)
  葛城美徳、安楽純子、中富満城、井出浩子、三嶋行雄、桜場喜行、権藤洋一、高木律夫、大島勇人、木南凌
- Organizer
  第34回日本分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2011-12-15
- Data Source
  KAKENHI-PROJECT-22592062
[Presentation] Loss of a Bcl11b allele promotes proliferation of stem cells in the mouse small intestine after γ-irradiation2011
- Author(s)
  葛城美徳、小幡美貴、三嶋行雄、木南凌
- Organizer
  第14回国際放射線研究会議
- Place of Presentation
  ワルシャワ、ポーランド
- Year and Date
  2011-08-28
- Data Source
  KAKENHI-PROJECT-22592062
[Presentation] BCL11B inhibits HDM2 expression in a p53-dependent manner2011
- Author(s)
  小幡、木南、三嶋
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜(神奈川県)
- Year and Date
  2011-09-23
- Data Source
  KAKENHI-PROJECT-22592062
[Presentation] 転写因子Bcl11bはp53経路を介して細胞増殖を抑制する2011
- Author(s)
  小幡、坂牧、木南、三嶋
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都国際会議場(京都府)
- Year and Date
  2011-09-23
- Data Source
  KAKENHI-PROJECT-22592062
[Presentation] p27/p57遺伝子内のBcl11b依存性転写活性化及び抑制化制御配列2010
- Author(s)
  小幡美貴、西川敦、木南凌、三嶋行雄
- Organizer
  第83回日本生化学会大会/第33回日本分子生物学会年会合同学会
- Place of Presentation
  神戸
- Year and Date
  2010-12-09
- Data Source
  KAKENHI-PROJECT-22592062
[Presentation] Bcl11bは腸上皮細胞の恒常性を制御する大腸がん抑制遺伝子である2010
- Author(s)
  葛城美徳、坂牧僚、小幡美貴、郷梨江香、三嶋行雄、権藤洋一、落合雅子、中釜斉、木南凌
- Organizer
  第83回日本生化学会大会/第33回日本分子生物学会年会合同学会
- Place of Presentation
  神戸
- Year and Date
  2010-12-08
- Data Source
  KAKENHI-PROJECT-22592062
[Presentation] Bcl111b heterozygosity promotes clonal expansion and differentiation arrest of thymocytes in gamma-irradiated mice2010
- Author(s)
  郷梨江香、広瀬智史、葛城美徳、三嶋行雄、木南凌
- Organizer
  第69回日本癌学会総会
- Place of Presentation
  大阪
- Year and Date
  2010-09-22
- Data Source
  KAKENHI-PROJECT-22592062
[Presentation] Bcl11b is an intestinal tumor suppressor that controls intestinal cell homeostasis2010
- Author(s)
  坂牧僚、葛城美徳、小幡美貴、落合雅子、中釜斉、権藤洋一、三嶋行雄、木南凌
- Organizer
  第69回日本癌学会総会
- Place of Presentation
  大阪
- Year and Date
  2010-09-22
- Data Source
  KAKENHI-PROJECT-22592062
[Presentation] Role of BCL11B in the SWI/SNF chromatin remodeling complexes
- Author(s)
  小幡　美貴・木南　凌・三嶋　行雄
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（横浜市）
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-25340027
[Presentation] Effect of mutations in BCL11B on the SWI/SNF chromatin remodeling complexes
- Author(s)
  小幡　美貴・木南　凌・葛城　美徳・三嶋　行雄
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  京都国際会館（京都）
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-25340027

1. OBATA Miki (00420307)

# of Collaborated Projects: 3 results

# of Collaborated Products: 26 results
2. KATSURAGI Yoshinori (60401759)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
3. KOMINAMI Ryo (40133615)

# of Collaborated Projects: 2 results

# of Collaborated Products: 14 results
4. 広瀬哲史 (10415276)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. HIROSE Satoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
6. HIGUCHI Masaya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. TAKAHASHI Masahiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 権藤洋一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 藤井雅寛

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

MISHIMA Yukio 三嶋 行雄

Research Projects

Research Products

Co-Researchers

Effect of BCL11B and its mutations on the radiation response: analysis of a p53-MDM2 feed-back loop

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Radiation target and mutagenesis in intestinal tumors

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of mouse teeth hyperplasia and gut tissue enlargement by mutation of transcription factor Bcl11bPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Bcl11b SWI/SNF-complex subunit modulates intestinal adenoma and regeneration after γ-irradiation through Wnt/β-catenin pathway.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Human T-cell leukemia virus type 1 Tax oncoprotein represses the expression of the BCL11B tumor suppressor in T-cells2015

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Successful management of severe intrahepatic cholestasis of pregnancy: report of a first Japanese case.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Bcl11b transcription factor plays a role in the maintenance of the ameloblast-progenitors in mouse adult maxillary incisors2013

Author(s)

Journal Title

Data Source

[Journal Article] Cell of origin in radiation-induced premalignant thymocytes in mice conditionally losing one Bcl11b allele2013

Author(s)

Journal Title

Data Source

[Journal Article] Cell of origin in radiation-induced premalignant thymocytes in mice conditionally losing one Bcl11b allele.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Bcl11b transcription factor plays a role in the maintenance of the ameloblast-progenitors in mouse adult maxillary incisors.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Impairment in differentiation and cell cycle of thymocytes by loss of a Bcl11b tumor suppressor allele that contributes to leukemogenesis2012

Author(s)

Journal Title

Data Source

[Journal Article] BCL11B tumor suppressor inhibits HDM2 expression in a p^53-dependent manner2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] BCL11B tumor suppressor inhibits HDM2 expression in a p53-dependent manner2012

Author(s)

Journal Title

Data Source

[Journal Article] Impairment in differentiation and cell cycle of thymocytes by loss of a Bcl11b tumor suppressor allele that contributes to leukemogenesis2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Bcl11b heterozygosity leads to age-related hearing loss and degeneration of outer hair cells of the mouse cochlea2011

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Bcl11b heterozygosity leads to age-related hearing loss and degeneration of outer hair cells of the mouse cochlea2011

MISHIMA Yukio 三嶋行雄