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OHKUMA Seitaro  大熊 誠太郎

ORCIDConnect your ORCID iD *help
Researcher Number 30152086
Other IDs
External Links
Affiliation (based on the past Project Information) *help 1996 – 2007: 川崎医科大学, 医学部, 教授
1986 – 1994: 京都府立医科大学, 医学部, 助教授
Review Section/Research Field
Principal Investigator
General pharmacology / 応用薬理学・医療系薬学 / Applied pharmacology
Except Principal Investigator
General pharmacology / Medical systems / Neurochemistry/Neuropharmacology / Biomedical engineering/Biological material science / 老化(加齢)
Keywords
Principal Investigator
up-regulation / β-arrestin / adenylate cyclase / nadolol / β-アドレナリン受容体 / cerebral cortical neurons / 大脳皮質神経細胞 / conditioned place preference / ryanodine trceptors / methamphetamine … More / alcohol / High voltage-gated Ca channels / drug dependence / [^3H]diltiazem結合 / アルコール(エタノール) / L型高電位開口性Ca^<2+>チャネル / ジアゼパム結合阻害蛋白質 / α1サブユニット / アンフェタミン / ニコチン / モルヒネ / エタノール / [3H]diltiazem結合 / L型高電位開口性カルシウムチャネル / ethanol / methanphetamine / CPP / ryanodine受容体 / メタンフェミン / アルコール / 高電位開口性カルシウムチャネル / 薬物依存 / cerebrocortical neurons / [3H] CGP-12177 binding / β-adrenoceptors / [^3H]CGP-12177結合 / 3H]CGP-12177結合 / [3H]CGP-12177結合 / peroxynitrite scavenger / hydroxyl radical / neurotransmitter release / Voltage-dependent Ca^<2+> channels / Ca^<2+> influx / peroxynitrite / ヒドロキシルラジカル / 神経伝達物質放出 / テトロドトキシン / cyclicGMP(cGMP) / L型VDCC活性薬 / ヒドロキシラジカル / 電位依存性Ca^<2+>チャネル / cyclic GMP(cGMP) / Ca^<2+>流入 / パーオキシニトライト / Ca^<2+> channels / GABA / nitric oxide / protooncogenes / neurons / beta-adrenocentors / Protooncogenes / Immediate early gene(IEG) / Immediate early gene (IEG) / 初代培養神経細胞 / Up-regulation / 受容体発現調節 / [^3H]MK-801 binding / Ca influx / NG108-15 cells / ca-channel blocker / GABA_A receptor / neuronal death / NMDA receptor / NG108-15 / [^3H]MK-801結合 / Ca細胞内流入 / NG108-15細胞 / カルシウムチャネル拮抗薬 / GABA_A受容体 / 神経細胞死 / NMDA受容体 / Cerebral Cortical Neuron / Primary Culture / PI Turnover / Muscarinic Acetylcholine Receptor / Adenylate Cyclase / beta-Adrenergic Receptor / G Protein / 細胞内情報伝達系 / 神経細胞 / 初代培養 / イノシト-ルリン脂質代謝回転 / ムスカリン受容体 / アデニレ-トシクラ-ゼ / βーアドレナリン受容体 / G蛋白 … More
Except Principal Investigator
アストログリア / 初代培養神経細胞 / 免疫組織化学 / Glycoprotein / Distribution in Brain / Immunohistochemistry / Receptor Antibody / Functional Reconstitution / Functional Coupling / C1 Channel / Benzodiazepine Receptor / GABA receptor / 機能的共役 / クロライドチャンネル / hybrid型糖鎖 / 糖蛋白 / 脳内分布 / レセプター抗体 / 機能再構成 / クロライドチャンネル、機能的共役 / ベンゾジアゼピン・レセプター / GABAレセプター / ultrasound therapy / myocardial ischemia / microvasculature / arterialization / cardiovascular system / 超音波治療 / 心筋虚血 / 微小血管構築 / 血管新生 / 循環器・高血圧 / High voltage-gated calcium channels / Calcium-induced calcium release / Cav β subunits / Cav1.2 subunits / IP3 receptors / Ryanodine receptors / Reward effects / Drug dependence / 細胞内カルシウム濃度 / Ca^<2+>センサー蛋白 / 依存性薬物 / L型高電位開口性カルシウムチャネル / 高電位開口性カルシウムチャネル / Ca^<2+>誘発Ca^<2+>放出 / β3サブユニット / α1Cサブユニット / IP3受容体 / リアノジン受容体 / 報酬効果 / 薬物依存 / EDRF / mesenteric microcirculation / reactive hyperemia / H_2O_2 / 腸間膜動脈 / in vivo / 毛細血管 / ペンシル型CCD生体顕微鏡 / 内皮由来過分極因子 / CU, Zn-SOD KO mice / 微小循環 / 虚血再灌流 / 腸間膜微小循環 / 内皮由来拡張物質 / 腸間服微小循環 / 反応性充血 / 過酸化水素 / DEVELOPMENT / NEURO TROPIC FACTOR / OSTEOPOROSIS / OSTEOBLASTS / 骨芽細胞 / development / Xenopos laevis / 遺伝子発現 / 骨代謝 / 神経 / 発生 / 骨粗鬆症 / パーキンソン病 / 錐体外路機能制御 / 黒質-線条体系ドーパミンニューロン / 線条体-淡蒼球系GABAニューロン / 線条体-黒質系GABAニューロン / カイニン酸 / MPTP / GABA_Aレセプター / 機能変化 / 初代培養細胞 / オリゴデンドログリア / GABAニューロン / ニューロン / 神経伝達物質 / 脳白質変性症 / 薬理学的性質 / 可溶化 / 活性化 / GAB【A_B】レセプター / カルシウムイオン / peroxynitrite / NOラジカル / アセチルコリン放出 / 電位依存型Ca^<2+>チャネル / Ca^<2+>influx / GABA_A受容体 / NMDA受容体 / 脳虚血モデル / NGF・mRNA / NGF / pH変化 / グルタミン / グルタミン酸 / アシドーシス / アシド-シス / 初代培養 / グルタミン酸取り込み / GABA取り込み / 神経細胞死 / 脳虚血 / 前シナプス性ヘテロレセプタ- / 前シナプス性オ-トレセプタ- / ムスカリン性M_1レセプタ- / GABA_Aレセプタ- / GABAニュ-ロン / 大脳皮質 / GABA放出調節 / 培養細胞 / 病態生理学的役割 / Alzheimer病起因物質 / Alzheimer病 / 無血清培養法 / 誘発物質の同定 / 起因物質の同定 / アルツハイマ-病 Less
  • Research Projects

    (20 results)
  • Research Products

    (14 results)
  • Co-Researchers

    (21 People)
  •  Identification of common biological markers underlying establishment of drug dependence and an attempt to develop pharmacogenomic therapy

    • Principal Investigator
      KATSURA Masashi
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      Kawasaki Medical School
  •  Establishment of ischemic cardiomyopathy-targeted microbubble-ultrasound therapy : effects on three-dimensional architecture of coronary microvasculature

    • Principal Investigator
      TOYOTA Eiji
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Medical systems
    • Research Institution
      Kawasaki Medical School
  •  Development of the pencil-typed imaging system to evaluate the disturbance of coronary microcirculation during coronary ischemia-reperfusion injury

    • Principal Investigator
      YADA Toyotaka
    • Project Period (FY)
      2004 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Biomedical engineering/Biological material science
    • Research Institution
      Kawasaki Medical School
  •  An attempt to develop pharmacogenomic therapy and prevention of drug dependence.Principal Investigator

    • Principal Investigator
      OHKUMA Seitaro
    • Project Period (FY)
      2003 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Applied pharmacology
    • Research Institution
      Kawasaki Medical School
  •  β-Adrenoceptor up-regulation and intracellular signal transduction systemsPrincipal Investigator

    • Principal Investigator
      OHKUMA Seitaro
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General pharmacology
    • Research Institution
      KAWASAKI MEDICAL SCHOOL
  •  Survey of peroxynitrite scavengers and its application for pathophysiolgyPrincipal Investigator

    • Principal Investigator
      OHKUMA Seitaro
    • Project Period (FY)
      1998 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      KAWASAKI MEDICAL SCHOOL
  •  Phamracological and molecular biological analyzes on regulatory mechanisms for neurotransmitter receptor expressionPrincipal Investigator

    • Principal Investigator
      OHKUMA Seitaro
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      KAWASAKI MEDICAL SCHOOL
  •  神経細胞死発症におけるNMDA受容体と他種伝達物質受容体相互作用の意義の解析

    • Principal Investigator
      栗山 欣弥
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kyoto Prefectural University of Medicine
  •  アストログリアにおける神経成長因子(NGF)の生成とその脳虚血に伴う変化の解析

    • Principal Investigator
      栗山 欣弥
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kyoto Prefectural University of Medicine
  •  Functional relationship between NMDA-induced neuronal injury and various neurotransmitter receptorsPrincipal Investigator

    • Principal Investigator
      OHKUMA Seitaro
    • Project Period (FY)
      1992 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      General pharmacology
    • Research Institution
      Kyoto Prefectural University of Medicine
  •  Studies on the gene expression of OSF-1 in osteoblasts derived from normal and osteoporosis patients.

    • Principal Investigator
      HASHIMOTO-GOTOH Tamotsu
    • Project Period (FY)
      1992 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      老化(加齢)
    • Research Institution
      Kyoto Pref.Univ.of Medicine
  •  脳虚血解除後の脳内微小環境における星状膠細胞の病態生理学的役割の解析

    • Principal Investigator
      栗山 欣弥
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kyoto Prefectural University of Medicine
  •  Alzheimer病の病態発現におけるAstrocytesの病態生理学的役割の解析

    • Principal Investigator
      栗山 欣弥
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kyoto Prefectural University of Medicine
  •  GABA作動性シナプスにおける前シナプス性オ-トレセプタ-の特性と機能の解析

    • Principal Investigator
      栗山 欣弥
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kyoto Prefectural University of Medicine
  •  Molecular biological analysis on regulatory mechanisms underlying the biosynthesis of GTP binding proteinPrincipal Investigator

    • Principal Investigator
      OHKUMA Seitaro
    • Project Period (FY)
      1990 – 1991
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      General pharmacology
    • Research Institution
      Kyoto Prefectural University of Medicine
  •  初代培養神経細胞を用いたアルツハイマ-病起因・誘発物質の同定とその性状の解析

    • Principal Investigator
      KURIYAMA Kinya
    • Project Period (FY)
      1989
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kyoto Prefectural University of Medicine
  •  錐体外路系の制御機構におけるGABA作働性ニューロンの役割に関する神経化学的研究

    • Principal Investigator
      栗山 欣弥
    • Project Period (FY)
      1987
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kyoto Prefectural University of Medicine
  •  カルシウムイオンによるγ-アミノ酪酸(GABA)ーフレセプターの活性化とその意義

    • Principal Investigator
      栗山 欣弥
    • Project Period (FY)
      1986
    • Research Category
      Grant-in-Aid for Special Project Research
    • Research Institution
      Kyoto Prefectural University of Medicine
  •  脳白質変性症における諸種伝達物質作働性ニューロンの機能変化解析と治療確立への応用

    • Principal Investigator
      栗山 欣弥
    • Project Period (FY)
      1986
    • Research Category
      Grant-in-Aid for Special Project Research
    • Research Institution
      Kyoto Prefectural University of Medicine
  •  Purification of -aminobutyric acid (GABA) receptor and formation of monoclonal antibody against the purified receptor.

    • Principal Investigator
      KURIYAMA Kinya
    • Project Period (FY)
      1984 – 1986
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      General pharmacology
    • Research Institution
      Kyoto Prefectural University of Medicine

All 2007 2006 2005 2004

All Journal Article Book

  • [Book] グッドマン・ギルマン薬理書(上) 薬物治療の基礎と臨床(第11版)2007

    • Author(s)
      大熊 誠太郎
    • Total Pages
      1206
    • Publisher
      廣川書店
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18500302
  • [Book] コア・カリキュラム対応 医学一般〔改訂2版〕(今西二郎 編)2005

    • Author(s)
      大熊誠太郎, 桂 昌司(分担)
    • Total Pages
      346
    • Publisher
      金芳堂
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390175
  • [Book] 医学薬理学(改訂4版)(遠藤政夫、栗山欣弥、大熊誠太郎、田中利夫、樋口宗史 編)2005

    • Author(s)
      大熊誠太郎
    • Total Pages
      739
    • Publisher
      南山堂
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390175
  • [Book] 医科薬理学2005

    • Author(s)
      大熊誠太郎
    • Total Pages
      739
    • Publisher
      南山堂
    • Data Source
      KAKENHI-PROJECT-15390175
  • [Book] 覚せい剤精神病と麻薬依存(佐藤光源、櫻井映子編)2004

    • Author(s)
      大熊誠太郎, 桂昌司(分担)
    • Total Pages
      186
    • Publisher
      東北大学出版会
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390175
  • [Journal Article] Expression of β-adrenergic receptor up-regulation is mediated by two different processes.2006

    • Author(s)
      Ohkuma S., et. al.
    • Journal Title

      Brain Res. 1112

      Pages: 114-25

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18500302
  • [Journal Article] Expression of β-adrenergic receptor up-regulation is mediated by two different processes.2006

    • Author(s)
      Ohkuma, S.
    • Journal Title

      Brain Research 1112

      Pages: 114-125

    • Data Source
      KAKENHI-PROJECT-18500302
  • [Journal Article] Expression of β-adrenergic receptor up-regulation is mediated by two different processes2006

    • Author(s)
      Ohkuma, S.
    • Journal Title

      Brain Research 1112

      Pages: 114-125

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18500302
  • [Journal Article] 【アルコール依存症 最近の話題】アルコール症の薬物療法2005

    • Author(s)
      大熊誠太郎 他
    • Journal Title

      最新精神医学 10

      Pages: 375-381

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390175
  • [Journal Article] アルコール長期曝露によるL型高電位開口性カルシウムチャネルの機能変化とその意義2005

    • Author(s)
      桂 昌司, 大熊誠太郎
    • Journal Title

      日本アルコール・薬物医学会雑誌 40

      Pages: 205-212

    • NAID

      10016593172

    • Data Source
      KAKENHI-PROJECT-15390175
  • [Journal Article] Chronic nicotine treatment upregulates L-type high voltage-gated calcium channels.2005

    • Author(s)
      Katsura, M., Ohkuma, S.
    • Journal Title

      J.Pharmacol.Sci. 97

      Pages: 344-347

    • Data Source
      KAKENHI-PROJECT-15390175
  • [Journal Article] 【アルコール依存症最近の話題】アルコール症の薬物療法2005

    • Author(s)
      大熊誠太郎, 桂 昌司
    • Journal Title

      最新精神医学雑誌 10

      Pages: 375-381

    • Data Source
      KAKENHI-PROJECT-15390175
  • [Journal Article] 内在性不安誘発物質の脳内発現変化とその意義2004

    • Author(s)
      桂 昌司, 大熊 誠太郎
    • Journal Title

      日本神経精神薬理学雑誌 24

      Pages: 119-123

    • NAID

      10013150185

    • Data Source
      KAKENHI-PROJECT-15390175
  • [Journal Article] Pharmacological basis for management of drug dependence2004

    • Author(s)
      Katsura, M., Ohkuma, S.
    • Journal Title

      Ann.N.Y.Acad.Sci. 1025

      Pages: 578-583

    • Data Source
      KAKENHI-PROJECT-15390175
  • 1.  KURIYAMA Kinya (20079734)
    # of Collaborated Projects: 10 results
    # of Collaborated Products: 0 results
  • 2.  KATSURA Masashi (80204452)
    # of Collaborated Projects: 8 results
    # of Collaborated Products: 7 results
  • 3.  TAGUCHI Jun-ichi (50188132)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 4.  HIROUCHI Masaaki (70181196)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  土橋 康成 (50106390)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  橋本 恒一 (00172867)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  HASHIMOTO-GOTOH Tamotsu (00237942)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  TSUJIMURA Atsushi (50236890)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  HIRASAWA Taisuke (40079851)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  SHIMOSATO Kazuaki (60154316)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  WATANABE Satoru (90069055)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  YADA Toyotaka (00210279)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  NAKAMOTO Hiroshi (10299183)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  GOTO Masami (50148699)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  OGASAWARA Yasuo (10152365)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  SHIBASAKI Masahiro (80412162)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  TOYOTA Eiji (30248215)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  YOSHIDA Kiyoshi (60322583)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  NEISHI Yoji (80319946)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  城守 美佐 (70177939)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  KAJIYA Fumihiko (70029114)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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