HIGASHI Yujiro 東雄二郎

Researcher Number	30181069
Other IDs
Affiliation (based on the past Project Information) *help	2019: 愛知県医療療育総合センター発達障害研究所, 障害モデル研究部, 客員研究員 2017 – 2018: 愛知県心身障害者コロニー発達障害研究所, 周生期学部, 客員研究者 2011 – 2017: 愛知県心身障害者コロニー発達障害研究所, 周生期学部, 部長 2008: Institute for Developmental Research, Aichi Human Service Center, 周生期学部, 部長 2007: Osaka University, Graduate School of Frontier Biosciences, Associate Professor … More 2002 – 2006: 大阪大学, 生命機能研究科, 助教授 1994 – 2001: 大阪大学, 細胞生体工学センター, 助教授 1995 – 1996: 大阪大学, 細胞工学センター, 助教授 1993: Osaka University, Institute for Molecular and Cellular Biology, Research Associate, 細胞生体工学センター, 助手 1992: 名古屋大学, 理学部, 助手 Less
Review Section/Research Field	Principal Investigator Biological Sciences / Developmental biology / Pediatrics / Endocrinology / Molecular biology / 分子細胞生物学 / Developmental biology Except Principal Investigator Molecular biology / Developmental biology / Pediatrics / Endocrinology
Keywords	Principal Investigator SIP1 / ノックアウトマウス / δEF1 / BMP / Smad / マウス胚発生 / ZFHX1ファミリー / 転写因子 / TGFβファミリーシグナル / 転写制御因子 … More / knockout mouse / TGFβ / モワット-ウィルソン症候群 / 精神遅滞 / 脳 / 神経 / 体節 / Notch関連シグナル因子 / 神経堤細胞 / 体節形成 / zfh / 発生 / zeb1 / 下垂体 / 内分泌 / 下垂体後葉 / 下垂体形成 / TUB family signaling / chink / neural development / mouse embryonic development / ZFHX1 family / SEF1 / ニワトリ / Notch signaling / Mouse development / Knockout mouse / ZFHX1 family transcription factor / zfhxlファミリー転写因子 / zfhx1ファミリー転写因子 / mouse development / ZFH1 / SMAD / BMPシグナル / zfh1 / Mouse / Development / Gene targeting / ES cells / Crystallin gene / Lens cells / Tissue specificity / Transcriptional Regulation / シーンターゲッティング / マウス / ジーンターゲッティング / ES細胞 / クリスタリン遺伝子 / レンズ細胞 / 組織特異性 / 転写制御 / モデルマウス / de novo変異 / SIP1遺伝子 / ZEBファミリー / SIP1 遺伝子 / SIP1ヘテロ欠損マウス / SIP1ノックアウトマウス / 遺伝・先天異常学 / 脳の構造と機能 / ZFHX1転写因子ファミリー / モワットウィルソン症候群 / zfhx1b / zeb2 / 性分化 / 外生殖器 / δEFF / ヒルシュブルング病 / Sox10 / TGFBシグナル / zfhx1 / zfhx1ファーミリー転写因子 / 神経管形成 / Cre-LoxPシステム / 四肢形成 / 骨形成 / ジーンターゲティング / ホメオドメイン / Zincfingerタンパク / Tリンパ球 / 標的遺伝子組み換え法 / Znフィンガー / 中胚葉組織 / マウス胚 … More Except Principal Investigator ノックアウトマウス / δEF1 / N-myc / ES細胞 / SOX / C-myc / L-myc / トランスジェニックマウス / クリスタリン / Sox / c-myc / Optic vesicle / Ectoderm / Transgenic mouse / Enhancer / Crystallin / Induction / Lens / 骨格形成 / T細胞 / 分化誘導 / Pax6 / HMGドメイン / 網膜原基 / 外胚葉 / エンハンサー / 誘導 / 水晶体 / embryo / transcription / KO mouse / LoxP / Cre / Ndr-1 / 胚発生 / 転写制御 / deltaEF1 / Transcription factors / Lens differentiation / 標的遺伝子組換え / δEF2 / 突然変異マウス / SEF1 / 水晶体特異性 / 転写制御因子 / 水晶体分化 / 不安 / セロトニン神経 / モワット・ウィルソン症候群 / 脳 / Sip1 / 神経 / セロトニン / 縫線核 / 転写因子 / 下垂体後葉 / 下垂体形成 / 内分泌学 / Max / TrichostatinA / σEF1 / SIP1 / CtBP / dEF1 / Ndr3 / Ndr2 / Ndr1 / マウス / レトロウイルスベクター / 相同遺伝子組換え / レロトウイルスベクター / ニワトリ / ゼブラフィッシュ / メダカ / 始原生殖細胞 / 相周遺伝子組換え / 遺伝子トラップ Less

Functional analysis of zeb1/deltaEF1 transcription factor on posterior pituitary development in mousePrincipal Investigator
- Principal Investigator
  
  Higashi Yujiro
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Endocrinology
- Research Institution
  Institute for Developmental Research Aichi Developmental Disability Center
The role of SIP1, the causative gene for Mowat-Wilson syndrome, in structural and functional development of brainPrincipal Investigator
- Principal Investigator
  
  Higashi Yujiro
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Institute for Developmental Research, Aichi Human Service Center
The role of Sip1 gene for development of the serotonergic neurons of the raphe
- Principal Investigator
  
  NISHIZAKI Yuriko
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Yokohama College of Pharmacy
  Institute for Developmental Research, Aichi Human Service Center
下垂体形成過程における転写因子δEF1の機能解析
- Principal Investigator
  
  松井ふみ子
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Endocrinology
- Research Institution
  Institute for Developmental Research, Aichi Human Service Center
The study on the role of SIP1, the causative gene for Mowat-Wilson syndrome in human, in structural and functional development of brain using mouse systemPrincipal Investigator
- Principal Investigator
  
  HIGASHI Yujiro
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Institute for Developmental Research, Aichi Human Service Center
外生殖器形成過程におけるZFHK1転写制御因子ファミリーの機能Principal Investigator
- Principal Investigator
  
  東雄二郎
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Institute for Developmental Research, Aichi Human Service Center
  Osaka University
Functional analysis of ZFHX1 family transcription factors in embryonic developmentPrincipal Investigator
- Principal Investigator
  
  HIGASHI Yujiro
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Developmental biology
- Research Institution
  Osaka University
初期胚の神経組織形成および体節形成過程における転写制御因子SIP1の機能解析Principal Investigator
- Principal Investigator
  
  東雄二郎
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
Functional analysis of ZFHX1 family transcription factors in embryonic developmentPrincipal Investigator
- Principal Investigator
  
  HIGASHI Yujiro
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Developmental biology
- Research Institution
  Osaka Unniversity
体節形成過程におけるδEF1/SIP1ファミリー転写制御因子の機能解析Principal Investigator
- Principal Investigator
  
  東雄二郎
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
体節形成過程におけるdEF1/SIP1ファミリー転写制御因子の機能解析Principal Investigator
- Principal Investigator
  
  東雄二郎
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
BMPシグナル伝達系の下流転写因子SEF1/SIP-1ファミリーの研究Principal Investigator
- Principal Investigator
  
  HIGASHI Yujiro
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Molecular biology
- Research Institution
  Osaka University
発がんと胚発生を支配する転写制御機構
- Principal Investigator
  
  近藤寿人
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Osaka University
四肢及び脊椎の形成における転写制御因子δEF1の機能解析Principal Investigator
- Principal Investigator
  
  東雄二郎
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
Assessment of individual functions of Myc family genes
- Principal Investigator
  
  KONDOH Hisato
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  Molecular biology
- Research Institution
  Osaka University
Multiple steps in cell differentiaion : the case of lens development
- Principal Investigator
  
  KONDOH Hisato
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Molecular biology
- Research Institution
  Osaka University
マウス胚中胚葉系組織の発生と分化における転写制御因子δEF1の機能Principal Investigator
- Principal Investigator
  
  東雄二郎
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Developmental biology
- Research Institution
  Osaka University
ES細胞を用いた未知遺伝子の検索
- Principal Investigator
  
  山村研一
- Project Period (FY)
  1993 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kumamoto University
Investigation of the basic process of cell differentiation utilizing mutant animals of crystallin regulators
- Principal Investigator
  
  KONDOH Hisato
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  Developmental biology
- Research Institution
  Osaka University
Analysis deltaEF1 protein function in vivo by gene targetingPrincipal Investigator
- Principal Investigator
  
  HIGASHI Yujiro
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  分子細胞生物学
- Research Institution
  Osaka University
  Nagoya University

All 2017 2016 2015 2014 2012 2007 Other

All Journal Article Presentation

[Journal Article] Loss of Zeb2 in mesenchyme-derived nephrons causes primary glomerulocystic disease.2016
- Author(s)
  Rasouly, H. M., Kumar, S., Chan, S., Pisarek-Horowitz, A., Sharma, R., Xi, Q. J., Nishizaki, Y., Higashi, Y., Salant, D. J., Maas, R. L., Lu, W.
- Journal Title
  
  Kidney Int.
  
  Volume: 90 Issue: 6 Pages: 1262-1273
- DOI
  10.1016/j.kint.2016.06.037
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461539
[Journal Article] The Zeb1 Transcription Factor Controls the Onset of Spinal Cord Astrocyte Precursor Emigration from the Ventricular Zone2016
- Author(s)
  Ohayon, D., Garces, A., Willy Joly, W., Soukkarieh, C., Takagi, T., Sabourin, J.-C., Eric Agius, E., Darling, D. S., De Santa Barbara, P., Higashi, Y., Stolt, C. C., Jean-Philippe Hugnot, J.-P., William D. Richardson, W. D., Patrick Carroll, P. and Pattyn, A.
- Journal Title
  
  Cell Reports
  
  Volume: 17 Issue: 6 Pages: 1473-1481
- DOI
  10.1016/j.celrep.2016.10.016
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461539
[Journal Article] Regulation of trunk neural crest delamination by δEF1 and Sip1 in the chicken embryo2016
- Author(s)
  Yasumi, T., Inoue, M., Maruhashi, M., Kamachi, Y., Higashi, Y., Kondoh, H., Uchikawa, M.
- Journal Title
  
  Dev. Growth. Differ.
  
  Volume: 58 Issue: 2 Pages: 205-214
- DOI
  10.1111/dgd.12256
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K14527, KAKENHI-PROJECT-25440106, KAKENHI-PROJECT-25290066, KAKENHI-PROJECT-26461539
[Journal Article] Sip1 regulates the generation of the inner nuclear layer retinal cell lineages in mammals.2016
- Author(s)
  Menuchin-Lasowski Y., Oren-Giladi P., Xie Q., Ezra-Elia R., Ofri R., Peled-Hajaj S., Farhy C., Higashi Y., Van de Putte T., Kondoh H., Huylebroeck D., Cvekl A., Ashery-Padan R.
- Journal Title
  
  Development. 143:2829-2841 (2016)
  
  Volume: 143 Issue: 15 Pages: 829-2841
- DOI
  10.1242/dev.136101
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461539, KAKENHI-PROJECT-26251024
[Journal Article] Transcription factor Zeb2 regulates commitment to plasmacytoid dendritic cell and monocyte fate.2016
- Author(s)
  Wu, X., Brisefio, C. G., Grajales-Reyes, G. E., Haldar, M., Iwata, A., Kretzer, N. M., Wumesh, KC., Tussiwand, R., Higashi, Y., Murphy, T. L., and Murphy, K. M.
- Journal Title
  
  Proc Natl Acad Sci U S A.
  
  Volume: 113 Issue: 51 Pages: 14775-14780
- DOI
  10.1073/pnas.1611408114
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461539
[Journal Article] De novo inbred heterozygous Zeb2/Sip1 mutant mice uniquely generated by germ-line conditional knockout exhibit craniofacial, callosal and behavioral defects associated with Mowat-Wilson syndrome2015
- Author(s)
  51.Takagi T, Nishizaki Y, Matsui F, Wakamatsu N, Higashi Y.
- Journal Title
  
  Hum Mol Genet.
  
  Volume: 24 Issue: 22 Pages: 6390-6402
- DOI
  10.1093/hmg/ddv350
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26461539, KAKENHI-PROJECT-26461557, KAKENHI-PROJECT-26462225
[Journal Article] SIP1 expression patterns in brain investigated by generating a SIP1-EGFP reporter knock-in mouse.2014
- Author(s)
  Nishizaki, Y., Takagi, T., Matsui, F. and Higashi, Y.
- Journal Title
  
  Genesis
  
  Volume: 52 Issue: 1 Pages: 56-67
- DOI
  10.1002/dvg.22726
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591525, KAKENHI-PROJECT-23791215, KAKENHI-PROJECT-25461399
[Journal Article] Dlx1&2-dependent expression of Zfhx1b (Sip1, Zeb2) regulates the fate switch between cortical and striatal interneurons.2012
- Author(s)
  McKinsey GL, Lindtner S, Trzcinski B, Visel A, Pennacchio LA, Huylebroeck D, Higashi Y, Rubenstein JL.
- Journal Title
  
  Neuron
  
  Volume: 77 Pages: 83-98
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591525
[Presentation] 63.zeb1 flox マウスの作製とそのzeb1およびzeb2 double floxマウスを用いたマウス発生過程におけるZEB転写制御因子ファミリーの機能解析2017
- Author(s)
  東雄二郎、高木豪、水谷友香、浅井真人
- Organizer
  第40回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K09896
[Presentation] Cre-LoxPシステムを利用したdenovo変異型ヒト疾患モデルマウスの作製2015
- Author(s)
  高木豪、東雄二郎
- Organizer
  第38回日本分子生物学会年会
- Place of Presentation
  神戸
- Year and Date
  2015-12-02
- Data Source
  KAKENHI-PROJECT-26461539
[Presentation] de novo型Sip1ヘテロ変異マウスを用いたMowat-Wilson syndrome のモデル動物としての有用性の検討2012
- Author(s)
  高木豪、東雄二郎
- Organizer
  第35回日本分子生物学会
- Place of Presentation
  福岡国際会議場
- Data Source
  KAKENHI-PROJECT-23591525
[Presentation] Identification of four zfhxl genes in zebrafish and comparison of their expression patterns during early embryogenesis2007
- Author(s)
  東雄二郎
- Organizer
  第40回日本発生生物学会
- Place of Presentation
  福岡国際会議場
- Year and Date
  2007-05-29
- Data Source
  KAKENHI-PROJECT-19040015
[Presentation] ゼブラフィッシュzfhx1遺伝子ファミリーの同定と胚発生過程における発現パターンの解析2007
- Author(s)
  東雄二郎
- Organizer
  第40回日本発生生物学会
- Place of Presentation
  福岡国際会議場
- Year and Date
  2007-05-28
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18570198
[Presentation] Identification of four zfhx1 genes in zebrafish and comparison of their expression patterns during early embryogenesis2007
- Author(s)
  東雄二郎
- Organizer
  第40回日本発生生物学会
- Place of Presentation
  福岡国際会議場
- Year and Date
  2007-05-29
- Data Source
  KAKENHI-PROJECT-18570198
[Presentation] Identification of four zthxl genes in zebrafish and comparison of their expression patterns during early embryogenesis2007
- Author(s)
  Higashi, Y
- Organizer
  The 40th annual meeting of the Japanese Society of Developmental Biologist
- Place of Presentation
  Fukuoka
- Year and Date
  2007-05-28
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18570198
[Presentation] Loss of Zeb2 Causes Glomerulocystic Kidney Disease in Mice.
- Author(s)
  Rasouly M.H., Chan S., Pisarek-Horowitz A., Nishizaki Y., Higashi Y., Lu W.
- Organizer
  Annual meeting of the American Society of Nephrology
- Place of Presentation
  Philadelphia, PA
- Year and Date
  2014-11-13 – 2014-11-16
- Data Source
  KAKENHI-PROJECT-26461557
[Presentation] モデルマウスを用いたモワット・ウィルソン症候群の病態形成の解析
- Author(s)
  高木豪、西崎有利子、松井ふみ子、東雄二郎
- Organizer
  第36回日本分子生物学会
- Place of Presentation
  神戸国際会議場（神戸）
- Data Source
  KAKENHI-PROJECT-23591525
[Presentation] レポーターノックインマウスを用いたモワット-ウィルソン症候群の原因遺伝子SIP1の発現解析
- Author(s)
  西崎有利子、高木豪、松井ふみ子、東雄二郎
- Organizer
  第36回日本分子生物学会
- Place of Presentation
  神戸国際会議場（神戸）
- Data Source
  KAKENHI-PROJECT-23591525
[Presentation] モデルマウスを用いたモワット・ウィルソン症候群の病態形成の解析
- Author(s)
  高木豪、西崎有利子、松井ふみ子、東雄二郎
- Organizer
  第36回日本分子生物学会
- Place of Presentation
  神戸国際会議場（神戸）
- Data Source
  KAKENHI-PROJECT-25461399
[Presentation] レポーターノックインマウスを用いたモワット-ウィルソン症候群の原因遺伝子SIP1の発現解析
- Author(s)
  西崎有利子、高木豪、松井ふみ子、東雄二郎
- Organizer
  第36回日本分子生物学会
- Place of Presentation
  神戸国際会議場（神戸）
- Data Source
  KAKENHI-PROJECT-25461399

1. KONDOH Hisato (70127083)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
2. KAMACHI Yusuke (90263334)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
3. NISHIZAKI Yuriko (90378901)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
4. 松井ふみ子 (10393133)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
5. ANDRAS Nagy

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 山村研一 (90115197)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 仲村春和 (90079690)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 若松佑子 (20026800)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 松居靖久 (40241575)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 中辻憲夫 (80237312)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 續輝久 (40155429)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 武田洋幸 (80179647)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 村松喬 (00030891)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

HIGASHI Yujiro 東 雄二郎

Research Projects

Research Products

Co-Researchers

Functional analysis of zeb1/deltaEF1 transcription factor on posterior pituitary development in mousePrincipal Investigator

Principal Investigator

Project Period (FY)

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The role of SIP1, the causative gene for Mowat-Wilson syndrome, in structural and functional development of brainPrincipal Investigator

Principal Investigator

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The role of Sip1 gene for development of the serotonergic neurons of the raphe

Principal Investigator

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下垂体形成過程における転写因子δEF1の機能解析

Principal Investigator

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The study on the role of SIP1, the causative gene for Mowat-Wilson syndrome in human, in structural and functional development of brain using mouse systemPrincipal Investigator

Principal Investigator

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Research Field

Research Institution

外生殖器形成過程におけるZFHK1転写制御因子ファミリーの機能Principal Investigator

Principal Investigator

Project Period (FY)

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Review Section

Research Institution

Functional analysis of ZFHX1 family transcription factors in embryonic developmentPrincipal Investigator

Principal Investigator

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Research Institution

初期胚の神経組織形成および体節形成過程における転写制御因子SIP1の機能解析Principal Investigator

Principal Investigator

Project Period (FY)

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Review Section

Research Institution

Functional analysis of ZFHX1 family transcription factors in embryonic developmentPrincipal Investigator

Principal Investigator

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体節形成過程におけるδEF1/SIP1ファミリー転写制御因子の機能解析Principal Investigator

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体節形成過程におけるdEF1/SIP1ファミリー転写制御因子の機能解析Principal Investigator

Principal Investigator

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Review Section

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BMPシグナル伝達系の下流転写因子SEF1/SIP-1ファミリーの研究Principal Investigator

Principal Investigator

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Research Institution

発がんと胚発生を支配する転写制御機構

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HIGASHI Yujiro 東雄二郎