AKIMOTO Toshio 秋元敏雄

Researcher Number	30184112
Other IDs
Affiliation (Current)	2022: 日本医科大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2017 – 2022: 日本医科大学, 医学部, 准教授 2013 – 2015: 日本医科大学, 医学部, 准教授
Review Section/Research Field	Except Principal Investigator Basic Section 55060:Emergency medicine-related / Pathological medical chemistry / Legal medicine / Basic Section 55030:Cardiovascular surgery-related / Basic Section 62010:Life, health and medical informatics-related
Keywords	Except Principal Investigator ノックアウトマウス / メルカプトピルビン酸硫黄転移酵素 / 硫化水素 / ポリスルフィド / Egr-1 / 腎虚血再灌流障害 / TNF / 抗酸化作用 / 不安様行動 / メルカプト乳酸システイン尿症 … More / セロトニン / セロトニン受容体 / 硫黄酸化物 / 不安行動 / アルコール代謝 / ADH1 / ADH3 / アルコール嗜好性 / アルコール肝障害 / アルコール依存 / 慢性アルコール摂取 / アルコール性肝障害 / アルコール依存症 / ピラゾール感受性 / 社会医学 / アルコール医学 / アルコール脱水素酵素 / アルコール代謝亢進 / アルコール性脂肪肝 / 急性アルコール投与 / 硫黄転移酵素 / 内分泌細胞 / メルカプトピルビン酸 / ペルスルフィド / 酵素反応中間体 / 一酸化硫黄 / 不安様行動異常 / 虚血性心疾患 / 内分泌組織 / セロトニンレセプター / TNF-α / IL-6 / 虚血再灌流障害 / 急性腎障害 / PD98059 / renal tubular necrosis / 急性尿細管壊死 / acute kidney injury / アクアポリン７ / del Nido心筋保護液 / AQP 7 / del NIDO心筋保護液 / AQP7 / del Nido / NMR / 階層モデル / 診断モデル / 混合病態 / モード解析 / ハプロ不全 / 遊離骨片 / 骨感染症 / 持続洗浄 / CLAP / 開放骨折 Less

Renal protection by haploinsufficiency of Egr-1 in renal ischemia-reperfusion injury.
- Principal Investigator
  
  新井正徳
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  Nippon Medical School
開放骨折への即時骨接合＋局所抗生剤高濃度持続投与法の感染率低下、遊離骨片温存作用
- Principal Investigator
  
  佐藤陽介
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  Nippon Medical School
アクアポリン7欠損とエイジングが心筋保護効果へもたらす影響を探る
- Principal Investigator
  
  井関陽平
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55030:Cardiovascular surgery-related
- Research Institution
  Nippon Medical School
ＮＭＲモード法による階層的疾患診断モデルの構築と混合病態の評価への応用可能性
- Principal Investigator
  
  平川慶子
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 62010:Life, health and medical informatics-related
- Research Institution
  Nippon Medical School
Analysis of the role of Egr-1 in renal ischemia-reperfusion injury using Egr-1 knockout mice
- Principal Investigator
  
  Arai Masatoku
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  Nippon Medical School
Hydrogen sulfide and sulfur oxdies production failure model: metabolic disorder in sulfurtransferase-knockout mice
- Principal Investigator
  
  Nagahara Noriyuki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Nippon Medical School
The roles of high Km ADH3 on alcohol metabolism and alcoholc disorders under chronic alcohol comsumpsion
- Principal Investigator
  
  Haseba Takeshi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Legal medicine
- Research Institution
  Nippon Medical School
Comprehensive study of sulfurtransferase-knockout mice associated with insufficiency of hydrogen sulfide production
- Principal Investigator
  
  NAGAHARA Noriyuki
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Nippon Medical School

All 2016 2015 2014 2013 Other

All Journal Article Presentation

[Journal Article] Alcohol dehydrogenase 3 ccontributes to the protection of liver from nonalcoholic steatohepatitis2015
- Author(s)
  Goto M., Kitamura H., Alam M-M., Ota N., Haseba T., Akimoto T., Shimizu A., T-Yamamoto T., Yamamoto M., Motohashi H.
- Journal Title
  
  Genes to Cells
  
  Volume: 20
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25460879
[Journal Article] Antioxidant enzyme, 3-mercaptopyruvate sulfurtransferase-knockout mice exhibit increased anxiety-like behaviors: a model for human mercaptolactate-cysteine disulfiduria2013
- Author(s)
  Nagahara N, Nagano M, Takaaki Ito T, Shimamura K, Akimoto T, Suzuki H
- Journal Title
  
  Scientific Reports
  
  Volume: 3 Pages: 1986-1986
- DOI
  10.1038/srep01986
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590392, KAKENHI-PROJECT-25460345
[Presentation] 慢性アルコール摂取によるアルコール代謝亢進に寄与するNon-ADH1 pathwayの正体2016
- Author(s)
  長谷場健、丸山基世、秋元敏夫
- Organizer
  35回アルコール医学生物学研究会学術集会（JASBRA)
- Place of Presentation
  東京
- Year and Date
  2016-01-22
- Data Source
  KAKENHI-PROJECT-25460879
[Presentation] 多機能酵素・3-メルカプトピルビン酸硫黄転移酵素ーノックアウトマウスの網羅的解析（ワークショップ：硫化水素（H2S）とポリサルファイド（H2Sn）のシグナル分子としての機能2015
- Author(s)
  永原則之、永野昌俊、伊藤隆明、秋元敏雄、鈴木秀典
- Organizer
  第88回日本生化学会大会
- Place of Presentation
  神戸
- Year and Date
  2015-12-01
- Invited
- Data Source
  KAKENHI-PROJECT-15K08322
[Presentation] Class I alcohol dehydrogenase (ADH 1) is indispensable for continuos alcohol drinking (CAD) to develop alcoholism2015
- Author(s)
  Haseba T. Maruyama M. Akimoto T. Ohno Y.
- Organizer
  15th ESBRA (European Society for Biomedical Research on Alcoholism)
- Place of Presentation
  Valencia, Spain
- Year and Date
  2015-09-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460879
[Presentation] 急性アルコール中毒下での臓器障害とアルコール脱水素酵素の役割2014
- Author(s)
  佐久間隆弘、長谷場　健、丸山基世、秋元敏雄、大野曜吉
- Organizer
  日本法医学会学術関東地方集会
- Place of Presentation
  東京
- Year and Date
  2014-11-08
- Data Source
  KAKENHI-PROJECT-25460879
[Presentation] Comprehensive analysis of MST knockout mouse: exhibition of increased anxiety-like behaviors
- Author(s)
  Nagahara N, Nagano M, Takaaki Ito T, Shimamura K, Akimoto T, Suzuki H
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24590392

1. NAGAHARA Noriyuki (10208043)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
2. ITO Takaaki (70168392)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
3. NAGANO Masatoshi (60271350)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
4. Arai Masatoku (60267127)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 山田真吏奈 (70508621)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. Haseba Takeshi (50156329)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
7. MARUYAMA Motoyo (60709757)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
8. 増野智彦 (00318528)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 井関陽平 (00817760)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 藤井正大 (60297926)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 別所竜蔵 (60281432)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 丸山雄二 (50328837)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 平川慶子 (30165162)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 小川令 (70398866)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 金涌佳雅 (80465343)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 山崎峰雄 (10277577)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 足立好司 (00231928)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 土肥輝之 (10575385)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 瀧口徹 (20787593)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 金史英 (90266859)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 佐藤陽介 (60892073)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 森田林平 (00362541)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 原義明 (20386197)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 平林篤志 (20643141)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 横堀将司 (70449271)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 鈴木秀典

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

AKIMOTO Toshio 秋元 敏雄

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[Journal Article] Alcohol dehydrogenase 3 ccontributes to the protection of liver from nonalcoholic steatohepatitis2015

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[Journal Article] Antioxidant enzyme, 3-mercaptopyruvate sulfurtransferase-knockout mice exhibit increased anxiety-like behaviors: a model for human mercaptolactate-cysteine disulfiduria2013

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[Presentation] 慢性アルコール摂取によるアルコール代謝亢進に寄与するNon-ADH1 pathwayの正体2016

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[Presentation] 多機能酵素・3-メルカプトピルビン酸硫黄転移酵素ーノックアウトマウスの網羅的解析（ワークショップ：硫化水素（H2S）とポリサルファイド（H2Sn）のシグナル分子としての機能2015

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[Presentation] Class I alcohol dehydrogenase (ADH 1) is indispensable for continuos alcohol drinking (CAD) to develop alcoholism2015

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[Presentation] 急性アルコール中毒下での臓器障害とアルコール脱水素酵素の役割2014

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[Presentation] Comprehensive analysis of MST knockout mouse: exhibition of increased anxiety-like behaviors

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AKIMOTO Toshio 秋元敏雄