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AKIMOTO Toshio  秋元 敏雄

ORCIDConnect your ORCID iD *help
Researcher Number 30184112
Other IDs
Affiliation (Current) 2022: 日本医科大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help 2017 – 2022: 日本医科大学, 医学部, 准教授
2013 – 2015: 日本医科大学, 医学部, 准教授
Review Section/Research Field
Except Principal Investigator
Basic Section 55060:Emergency medicine-related / Pathological medical chemistry / Legal medicine / Basic Section 55030:Cardiovascular surgery-related / Basic Section 62010:Life, health and medical informatics-related
Keywords
Except Principal Investigator
ノックアウトマウス / メルカプトピルビン酸硫黄転移酵素 / 硫化水素 / ポリスルフィド / Egr-1 / 腎虚血再灌流障害 / TNF / 抗酸化作用 / 不安様行動 / メルカプト乳酸システイン尿症 … More / セロトニン / セロトニン受容体 / 硫黄酸化物 / 不安行動 / アルコール代謝 / ADH1 / ADH3 / アルコール嗜好性 / アルコール肝障害 / アルコール依存 / 慢性アルコール摂取 / アルコール性肝障害 / アルコール依存症 / ピラゾール感受性 / 社会医学 / アルコール医学 / アルコール脱水素酵素 / アルコール代謝亢進 / アルコール性脂肪肝 / 急性アルコール投与 / 硫黄転移酵素 / 内分泌細胞 / メルカプトピルビン酸 / ペルスルフィド / 酵素反応中間体 / 一酸化硫黄 / 不安様行動異常 / 虚血性心疾患 / 内分泌組織 / セロトニンレセプター / TNF-α / IL-6 / 虚血再灌流障害 / 急性腎障害 / PD98059 / renal tubular necrosis / 急性尿細管壊死 / acute kidney injury / アクアポリン7 / del Nido心筋保護液 / AQP 7 / del NIDO心筋保護液 / AQP7 / del Nido / NMR / 階層モデル / 診断モデル / 混合病態 / モード解析 / ハプロ不全 / 遊離骨片 / 骨感染症 / 持続洗浄 / CLAP / 開放骨折 Less
  • Research Projects

    (8 results)
  • Research Products

    (7 results)
  • Co-Researchers

    (26 People)
  •  Renal protection by haploinsufficiency of Egr-1 in renal ischemia-reperfusion injury.

    • Principal Investigator
      新井 正徳
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55060:Emergency medicine-related
    • Research Institution
      Nippon Medical School
  •  開放骨折への即時骨接合+局所抗生剤高濃度持続投与法の感染率低下、遊離骨片温存作用

    • Principal Investigator
      佐藤 陽介
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55060:Emergency medicine-related
    • Research Institution
      Nippon Medical School
  •  アクアポリン7欠損とエイジングが心筋保護効果へもたらす影響を探る

    • Principal Investigator
      井関 陽平
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55030:Cardiovascular surgery-related
    • Research Institution
      Nippon Medical School
  •  NMRモード法による階層的疾患診断モデルの構築と混合病態の評価への応用可能性

    • Principal Investigator
      平川 慶子
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 62010:Life, health and medical informatics-related
    • Research Institution
      Nippon Medical School
  •  Analysis of the role of Egr-1 in renal ischemia-reperfusion injury using Egr-1 knockout mice

    • Principal Investigator
      Arai Masatoku
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55060:Emergency medicine-related
    • Research Institution
      Nippon Medical School
  •  Hydrogen sulfide and sulfur oxdies production failure model: metabolic disorder in sulfurtransferase-knockout mice

    • Principal Investigator
      Nagahara Noriyuki
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Nippon Medical School
  •  The roles of high Km ADH3 on alcohol metabolism and alcoholc disorders under chronic alcohol comsumpsion

    • Principal Investigator
      Haseba Takeshi
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Legal medicine
    • Research Institution
      Nippon Medical School
  •  Comprehensive study of sulfurtransferase-knockout mice associated with insufficiency of hydrogen sulfide production

    • Principal Investigator
      NAGAHARA Noriyuki
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Nippon Medical School

All 2016 2015 2014 2013 Other

All Journal Article Presentation

  • [Journal Article] Alcohol dehydrogenase 3 ccontributes to the protection of liver from nonalcoholic steatohepatitis2015

    • Author(s)
      Goto M., Kitamura H., Alam M-M., Ota N., Haseba T., Akimoto T., Shimizu A., T-Yamamoto T., Yamamoto M., Motohashi H.
    • Journal Title

      Genes to Cells

      Volume: 20

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25460879
  • [Journal Article] Antioxidant enzyme, 3-mercaptopyruvate sulfurtransferase-knockout mice exhibit increased anxiety-like behaviors: a model for human mercaptolactate-cysteine disulfiduria2013

    • Author(s)
      Nagahara N, Nagano M, Takaaki Ito T, Shimamura K, Akimoto T, Suzuki H
    • Journal Title

      Scientific Reports

      Volume: 3 Pages: 1986-1986

    • DOI

      10.1038/srep01986

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590392, KAKENHI-PROJECT-25460345
  • [Presentation] 慢性アルコール摂取によるアルコール代謝亢進に寄与するNon-ADH1 pathwayの正体2016

    • Author(s)
      長谷場健、丸山基世、秋元敏夫
    • Organizer
      35回アルコール医学生物学研究会学術集会(JASBRA)
    • Place of Presentation
      東京
    • Year and Date
      2016-01-22
    • Data Source
      KAKENHI-PROJECT-25460879
  • [Presentation] 多機能酵素・3-メルカプトピルビン酸硫黄転移酵素ーノックアウトマウスの網羅的解析(ワークショップ:硫化水素(H2S)とポリサルファイド(H2Sn)のシグナル分子としての機能2015

    • Author(s)
      永原則之、永野昌俊、伊藤隆明、秋元敏雄、鈴木秀典
    • Organizer
      第88回日本生化学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-12-01
    • Invited
    • Data Source
      KAKENHI-PROJECT-15K08322
  • [Presentation] Class I alcohol dehydrogenase (ADH 1) is indispensable for continuos alcohol drinking (CAD) to develop alcoholism2015

    • Author(s)
      Haseba T. Maruyama M. Akimoto T. Ohno Y.
    • Organizer
      15th ESBRA (European Society for Biomedical Research on Alcoholism)
    • Place of Presentation
      Valencia, Spain
    • Year and Date
      2015-09-12
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25460879
  • [Presentation] 急性アルコール中毒下での臓器障害とアルコール脱水素酵素の役割2014

    • Author(s)
      佐久間隆弘、長谷場 健、丸山基世、秋元敏雄、大野曜吉
    • Organizer
      日本法医学会学術関東地方集会
    • Place of Presentation
      東京
    • Year and Date
      2014-11-08
    • Data Source
      KAKENHI-PROJECT-25460879
  • [Presentation] Comprehensive analysis of MST knockout mouse: exhibition of increased anxiety-like behaviors

    • Author(s)
      Nagahara N, Nagano M, Takaaki Ito T, Shimamura K, Akimoto T, Suzuki H
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-24590392
  • 1.  NAGAHARA Noriyuki (10208043)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 3 results
  • 2.  ITO Takaaki (70168392)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 3 results
  • 3.  NAGANO Masatoshi (60271350)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 3 results
  • 4.  Arai Masatoku (60267127)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  山田 真吏奈 (70508621)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  Haseba Takeshi (50156329)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 7.  MARUYAMA Motoyo (60709757)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 8.  増野 智彦 (00318528)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  井関 陽平 (00817760)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  藤井 正大 (60297926)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  別所 竜蔵 (60281432)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  丸山 雄二 (50328837)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  平川 慶子 (30165162)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  小川 令 (70398866)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  金涌 佳雅 (80465343)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  山崎 峰雄 (10277577)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  足立 好司 (00231928)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  土肥 輝之 (10575385)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  瀧口 徹 (20787593)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  金 史英 (90266859)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  佐藤 陽介 (60892073)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  森田 林平 (00362541)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  原 義明 (20386197)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  平林 篤志 (20643141)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  横堀 将司 (70449271)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  鈴木 秀典
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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