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Morinobu Shigeru  森信 繁

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… Alternative Names

MORINOBU Shigeru  森信 繁

森信 滋  モリノブ シゲル

森 信繁

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Researcher Number 30191042
Other IDs
External Links
Affiliation (Current) 2025: 広島国際大学, 健康科学部, 教授
Affiliation (based on the past Project Information) *help 2023 – 2024: 広島国際大学, 健康科学部, 教授
2017 – 2023: 吉備国際大学, 保健医療福祉学部, 教授
2015 – 2016: 高知大学, 教育研究部医療学系臨床医学部門, 教授
2015: 高知大学, 教育研究部医療学系臨床部門, 教授
2015: 広島大学, 医歯薬保健学研究院, 特任教授 … More
2014 – 2015: 高知大学, 医学部, 教授
2013 – 2015: 高知大学, 医歯学系, 教授
2014: 高知大学, 教育研究部医療系, 教授
2013: 高知大学, 教育研究部・医療学系, 教授
2013: 高知大学, 教育研究部医療学系, 教授
2012: 広島大学, 医歯(薬)学総合研究科, 特任教授
2012: 広島大学, 医歯薬保健学研究院, 特任教授
2012: 広島大学, 大学院・医歯薬保健学研究院, 特任教授
2011: 広島大学, 医歯(薬)学総合研究科, 准教授
2010: 広島大学, 大学院・医歯薬学合研究科, 准教授
2007 – 2010: Hiroshima University, Graduate School of Biomedical Sciences, Associate Professor
2006: 広島大学, 大学院医歯薬学総合研究科, 助教授
2002 – 2005: 広島大学, 大学院・医歯薬学総合研究科, 助教授
1999 – 2002: 広島大学, 医学部, 助教授
1998: 滋賀医科大学, 医学部, 講師
1994 – 1997: 山形大学, 医学部, 講師
1989: Yamagata University School of Medicine Department of Neuro-Psychiatry Instructor, 医学部・精神神経医学講座, 助手
1989: 山形大学, 医学部付属病院 精神神経医学講座, 教授
1988: 山形大学, 医学部付属病院・精神神経科, 助手 Less
Review Section/Research Field
Principal Investigator
Psychiatric science / Psychiatric science / Basic Section 52030:Psychiatry-related / Biological Sciences / Biological Sciences
Except Principal Investigator
Psychiatric science / Psychiatric science / Basic Section 52030:Psychiatry-related / Medium-sized Section 58:Society medicine, nursing, and related fields / Basic Section 59010:Rehabilitation science-related … More / Cognitive science / Complex systems / Hygiene and public health / 広領域 / General pharmacology / Public health/Health science / Rehabilitation science/Welfare engineering Less
Keywords
Principal Investigator
BDNF / うつ病 / ストレス / 海馬 / メチル化 / リン酸化 / Stress / 母子分離 / 難治性うつ病 / GDNF … More / IGF-1R / 拘束ストレス / p38 / ATF-2 / JNK interacting protein (JIP) / c-Jun / calcineurin / CREB / forskolin / antidepressant / phosphodiesterase / MAP kinase / trkB / DNAメチル化 / スパイン / ヒストン・アセチル化 / 抗うつ薬 / MeCP2 / fear extinction / RNA methylation / 恐怖記憶の消去 / ALKBH5 / FTO / METTL / N6-methyladenosine / Single prolonged stress / 消去障害 / 恐怖記憶 / PTSD / RNAメチル化 / Depression / Dnmt / Genome editing / Methylation / Dnmt3a / DNMT3a / Tet1 / DNA methylation / 脳由来神経栄養因子(BDNF) / 治療薬反応性 / Copy Number Variant / リチウム / Bipolar Disorder / Copy Number Variation / 双極性障害 / Biomarker / CNV / Lithium / GSK3beta / Bipolar disorder / hippocampus / epigenetics / histone acetylation / immobilization stress / neonatal isolation / Chip Assay / アセチル化 / 転写調節機能 / Chip assay / ヒストン / IGF-1 / バルプロ酸 / 豊かな環境 / エピジェネティクス / Phosphorylation / Neonatal isolation / Restraint stress / c-Jun NH2-terminal kinase / 探索行動 / 大脳皮質 / c-Jun N-terminal kinase (JNK) / c-Jun N-terminal kinases / ストレス性精神障害 / 大脳皮質前頭部 / c-Jun N-terminal kin / 母子分離ストレス / c-Jun NH2-terminal Kinase (JNK) / phosphorylation / phospho-CREB / Org4428 / desipramine / Paroxetin / Calcinevrin / 転写因子 / Calcineurin / Phrsphodiesterasc / Trk-B / Ant deorpsiant / phosdhodiesterase / MAP / Trk B / Gurikolin / phothodiestrerait / Articlepreiiant / trk B / グルココルチコイド受容体 / 動物モデル / Golgi染色 / 外傷後ストレス障害(PTSD) / 5-HTT / NTRK2 / 5-HT受容体 / SLC3A4 / 自殺 / 不遇な養育環境 / SLC6A4 / バイオマーカー / 自殺予測 / LIMK-1 / microRNA / IMK-1 / miR-200a / miR-141 / miR-30a / miR-132 / trkB受容体 / 学習性無力 / マイクロRNA / 樹状突起スパイン / 脳由来神経栄養因子 / DTI / プロモーター / 電気けいれん療法 / 大脳白質構造 / 拡散テンソル画像 / MRI / うつ病モデル / 白血球 / 電気けいれん治療 / 難治性うっ病 … More
Except Principal Investigator
BDNF / うつ病 / PTSD / 疫学 / エピジェネティクス / DNAメチル化 / 前頭前野 / 摂食障害 / Sensory Gating System / Neuro2A / estradiol / DNAメチル化障害 / SCID / 高齢者 / 小うつ病性障害 / メチル化障害 / 大うつ病性障害 / 情動 / 母子分離 / ストレス / 加齢 / 低出力パルス超音波 / 恐怖記憶消去障害 / エピジェネティック / 健康支援 / 環境影響 / エピジェネティックス / 血清 mature BDNF / 全ゲノム解析 / 量的形質遺伝子座 / 環境 / mRNA / BDNF遺伝子 / 神経保護・修復 / 頭部外傷 / 神経保護・修復作用 / オリゴデンドロサイト前駆細胞 / リハビリ / 細胞移植 / 新生児低酸素虚血性白質障害 / 機能再建 / 運動刺激 / シナプス / 神経細胞樹状突起 / ミエリン形成 / 運動機能 / 豊かな環境飼育 / サイクロスポリンA / オリゴデンドロサイト前駆細胞移植 / 新生仔低酸素虚血性白質障害 / 事故予測 / DLB / 運転能力評価 / 注意機能 / 交通事故予測 / 自動車運転 / 事故予防 / 交通事故 / 運転能力 / レビー小体型認知症 / 認知症 / 言語 / 身体自己像 / 対人コミュニケーション / 神経モジュレーション / Quality of Life / 社会的孤立 / 自己制御精神 / 身体像 / 社会的文脈 / 発達 / 心理社会的介入 / 分子 / 社会行動障害 / 自己制御修復 / メタ認知 / 気分障害 / 統合失調症 / 思春期 / 自己制御 / DSM-IV / DSM-Ⅳ / 縦断研究 / phosphoinositide hydrolysis / EEG / Acetylcholine esterase / HVA / 5-HIAA / Dementia of the Alzheimer type / cerebral blood flow / physostigmine / カルバコール / フォスファチシルハイノシトール / 脳波パワースペクトル / アセチルコリンエステレース / 局所脳血流量 / アルツハイマー病 / アルツハイマー型老年痴呆 / アセチルコリンエステレ-ス活性 / HVA濃度 / 脳波パワ-値 / イノシト-ル燐酸代謝 / 5-HIAA濃度 / 脳血流量 / フィゾスチグミン / アルツハイマ-型痴呆 / hippocampus / Stress Vulnerability / Maternal Deprivation / Neuroplasticity / Depression / Mood Disorders / 神経栄養因子 / 双極性障害 / 動物モデル / 双極性障害神経可塑性神経可塑性 / 母子分離動物モデル / 海馬 / ストレス脆弱性 / 神経可塑性 / 感情障害 / thapshigargin / sodium fluoride / cell damage / neurosteroids / 3-beta-HSD / P450-SCC / デヒドロエピアンドロステロン硫酸エステル / デヒドロエピアンドロステロン / beta-エストラジオール / 細胞内カルシウム / BAPTA / thapsigargin / フッ化ナトリウム / 細胞障害 / 神経ステロイド / 脳虚血 / オートファジー / 膜輸送 / セロトニントランスポーター / 小胞体関連分解 / ミクログリア / 神経突起伸長 / Gタンパク質共役受容体 / アミロイド凝集 / 神経変性疾患 / heat shock protein / macropinocytosis / neurodegeneration / neurite outgrowth / microglia / GPCR / serotonin transporter / protein kinase C / GRID-HAMD / 後期高齢者 / 脳由来神経栄養因子(BDNF) / 地域精神保健 / うつ尺度 / MRI / 痛み / CBT / うつ / 自己関連付け課題 / うつ傾向 / Self-Referential Task / 精神生理学 / 神経脱落の抑制・改善 / 姿勢制御能力 / 歩行能力 / セロトニン / 移動能力低下 / 脊髄前角細胞 / 骨格筋 / 移動能力 / 運動介入 / 抗老化 / pro-domain / 坑うつ薬 / 抗うつ薬 / 強制水泳 / HDAC阻害薬 / paroxetine / open filed locomotor / 高架式十時迷路 / d-cycloserine / 恐怖記憶の消去 / NMDA受容体 / 恐怖条件付け試験 / ヒストン / extinction / イノシトール燐脂質代謝 / マイクロダイアリシス / イノシトール燐脂質 / セカンドメッセンジャー / ムスカリン受容体 / アセチルコリン / 加齡 Less
  • Research Projects

    (29 results)
  • Research Products

    (115 results)
  • Co-Researchers

    (63 People)
  •  低出力パルス超音波を用いたPTSDの恐怖記憶消去障害の新規治療法の開発

    • Principal Investigator
      岡田 怜
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52030:Psychiatry-related
    • Research Institution
      Hiroshima University
  •  Elucidation of the involvement of RNA methylation in impairment of fear memory extinction in PTSD and development of a new therapyPrincipal Investigator

    • Principal Investigator
      森信 繁
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52030:Psychiatry-related
    • Research Institution
      Hiroshima International University
      Kibi International University
  •  DNAメチル化障害とその量的形質遺伝子座を用いた健康支援研究のモデル開発

    • Principal Investigator
      井原 一成
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Challenging Research (Pioneering)
    • Review Section
      Medium-sized Section 58:Society medicine, nursing, and related fields
    • Research Institution
      Hirosaki University
  •  Development of newer animal model, biomarker, and treatment of depression by regulation of BDNFgene methylation using genome editingPrincipal Investigator

    • Principal Investigator
      Morinobu Shigeru
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52030:Psychiatry-related
    • Research Institution
      Kibi International University
  •  Combination treatment of stem cell and exercise therapies in a Wistar Kyoto rat model of traumatic brain injury

    • Principal Investigator
      TAJIRI NAOKI
    • Project Period (FY)
      2018 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 59010:Rehabilitation science-related
    • Research Institution
      Nagoya City University
  •  Driving assessment in DLB

    • Principal Investigator
      KAMIMURA Naoto
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cognitive science
    • Research Institution
      Kochi University
  •  A longitudinal study of epigenetic epidemiology for the primary and secondary prevention of elderly depression

    • Principal Investigator
      IHARA Kazushige
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hygiene and public health
    • Research Institution
      Toho University
  •  Development of the therapeutic biomarker in bipolar disorder using CNV and methylation of target genes of mood stabilizersPrincipal Investigator

    • Principal Investigator
      Morinobu Shigeru
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Psychiatric science
    • Research Institution
      Kibi International University
      Kochi University
  •  エピジェネティクスと組織化学的手法によるPTSDの病態解明と予防法の開発Principal Investigator

    • Principal Investigator
      森信 繁
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      Kochi University
  •  Screening and development of drugs that can contribute to the treatment of intractable neuropsychiatric disease by regulating membrane trafficking and lysosomal degradation.

    • Principal Investigator
      Sakai Norio
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General pharmacology
    • Research Institution
      Hiroshima University
  •  A study on brain mechanisms of emotional control and restoring mechanisms to their disturbance

    • Principal Investigator
      SHIGETO Yamawaki
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Psychiatric science
    • Research Institution
      Hiroshima University
  •  Epidemiologic study on epigenetics related to BDNF for primary and secondary prevention of depression in the elderly

    • Principal Investigator
      IHARA Kazushige
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Public health/Health science
    • Research Institution
      Toho University
  •  Can exercise maintain and/or improve age-related changes in function and morphology of nervous system responsible for postural and locomotor control?

    • Principal Investigator
      TAKEMOTO Hidenori
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Rehabilitation science/Welfare engineering
    • Research Institution
      Prefectural University of Hiroshima
  •  Development of the biomarker for suicide prediction using the methylation at the gene promotersPrincipal Investigator

    • Principal Investigator
      MORINOBU Shigeru
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Psychiatric science
    • Research Institution
      Kochi University
      Hiroshima University
  •  Integrating molecular and psychosocial approach for assisting adolescent mind development and self-regulation

    • Principal Investigator
      Kasai Kiyoto
    • Project Period (FY)
      2011 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Complex systems
    • Research Institution
      The University of Tokyo
  •  The role of pro-domain BDNF in depression

    • Principal Investigator
      MATSUMOTO Tomoya
    • Project Period (FY)
      2009 – 2010
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Research Field
      Psychiatric science
    • Research Institution
      Hiroshima University
  •  エピジェネティクスと大脳白質微細構造によるうつ病発症・難治化の機序解明Principal Investigator

    • Principal Investigator
      森信 繁
    • Project Period (FY)
      2008 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Hiroshima University
  •  Elucidation of pathophysiology of refractory depression and development of newer treatment based on the disturbance of spine dynamicsPrincipal Investigator

    • Principal Investigator
      MORINOBU Shigeru
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Psychiatric science
    • Research Institution
      Hiroshima University
  •  クロマチン・リモデニングからみた新たなうつ病の病態解明と治療法開発の糸口発見

    • Principal Investigator
      YAMAWAKI Shigeto
    • Project Period (FY)
      2008 – 2009
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Psychiatric science
    • Research Institution
      Hiroshima University
  •  エピジェネティクスによるうつ病発症・難治化の機序解明Principal Investigator

    • Principal Investigator
      森信 繁
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Hiroshima University
  •  The study of vulnerability for PTSD and the development of newer treatment using PTSD model rats

    • Principal Investigator
      KOZURU Toshiro
    • Project Period (FY)
      2006 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Psychiatric science
    • Research Institution
      Hiroshima University
  •  Elucidation of the epigenetic mechanism of stress-related mental disorders-Identification of the transcriptional dysfunction in response to early environments and development of a new therapeutic strategy-Principal Investigator

    • Principal Investigator
      MORINOBU Shigeru
    • Project Period (FY)
      2005 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Psychiatric science
    • Research Institution
      Hiroshima University
  •  Study on Emotional Neuroplasticity in the Pathophysiology of Affective Disorders

    • Principal Investigator
      YAMAWAKI Shigeto
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      広領域
    • Research Institution
      HIROSHIMA UNIVERSITY
  •  Research for the involvement of the JNKs/c-Jun axis in the pathogenesis of stress-related psychiatric disordersPrincipal Investigator

    • Principal Investigator
      MORINOBU Shigeru
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Psychiatric science
    • Research Institution
      Hiroshima University
  •  Analysis of signal transduction mediated by neurosteroids as molecular mechanisms of emotion

    • Principal Investigator
      KAGAYA Ariyuki
    • Project Period (FY)
      2001 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Psychiatric science
    • Research Institution
      Hiroshima International University Faculty of Health and Welfare
      Hiroshima University
  •  The involvement of the dysfunction of transcrption factor in the pathogenesis of stress-related psychiatric disordersPrincipal Investigator

    • Principal Investigator
      MORINOBU Shigeru
    • Project Period (FY)
      1998 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Psychiatric science
    • Research Institution
      Hiroshima University
      Shiga University of Medical Science
  •  The involvement of the BDNF signal transduction to the pathogenesis of ssstress-related psychiatric disordersPrincipal Investigator

    • Principal Investigator
      MORINOBU Shigeru
    • Project Period (FY)
      1995 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Psychiatric science
    • Research Institution
      Yamagata University
  •  加齡による中枢神経伝達機能の変化とコリン作動薬の作用に関する研究

    • Principal Investigator
      TOTSUKA Shiro
    • Project Period (FY)
      1992 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Psychiatric science
    • Research Institution
      Yamagata University
  •  ACETYLCHOLINESTERASE INHIBITOR TREATMENT OF PATIENTS WITH DEMENTIA OF THE ALZHEIMER TYPE

    • Principal Investigator
      TOTSUKA Shiro
    • Project Period (FY)
      1988 – 1989
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Psychiatric science
    • Research Institution
      Yamagata University School of Medicine Department of Neuro-Psychiatry

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All Journal Article Presentation Book

  • [Book] BDNF 遺伝子のメチル化を用いたうつ病バイオマーカーの開発. 別冊・医学のあゆみ2014

    • Author(s)
      森信 繁, 淵上 学, 瀬川昌弘, 岡田怜
    • Data Source
      KAKENHI-PROJECT-23659566
  • [Book] 気分障害の薬理・生化学2012

    • Author(s)
      森信繁、淵上学
    • Total Pages
      335
    • Publisher
      医薬ジャーナル社
    • Data Source
      KAKENHI-PROJECT-23659566
  • [Book] 気分障害のBDNF 仮説とエピジェネティクス. 気分障害の薬理・生化学. 躁うつ病の薬理・生化学的研究懇話会 編2012

    • Author(s)
      森信 繁, 淵上 学
    • Publisher
      医薬ジャーナル社, 東京
    • Data Source
      KAKENHI-PROJECT-23659566
  • [Book] 脳とこころのプライマリケア1うつと不安(シナジー、下田和孝編)2010

    • Author(s)
      森信繁
    • Data Source
      KAKENHI-PROJECT-20591368
  • [Book] こころの医学事典(樋口輝彦、野村総一郎編)2010

    • Author(s)
      森信繁
    • Publisher
      日本評論社
    • Data Source
      KAKENHI-PROJECT-20591368
  • [Book] PTSD : Brain Mechanisms and Clinical Implication2006

    • Author(s)
      Shigeru Morinobu
    • Total Pages
      304
    • Publisher
      Springer
    • Data Source
      KAKENHI-PROJECT-17591214
  • [Book] Early experience and development of mind.2005

    • Author(s)
      Morinobu S.
    • Total Pages
      271
    • Publisher
      Kubapro(Japanese)
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14570925
  • [Book] 乳幼児の養育環境とこころの発達-分子精神医学という立場から-2005

    • Author(s)
      森信 繁
    • Total Pages
      271
    • Publisher
      クバプロ
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14570925
  • [Journal Article] Neonatal Isolation Increases the Susceptibility to Learned Helplessness through the Aberrant Neuronal Activity in the Ventral Pallidum of Rats2024

    • Author(s)
      Kobayashi Hironori、Fuchikami Manabu、Oga Kenichi、Miyagi Tatsuhiro、Fujita Sho、Fujita Satoshi、Okada Satoshi、Okamoto Yasumasa、Morinobu Shigeru
    • Journal Title

      Clinical Psychopharmacology and Neuroscience

      Volume: 22 Issue: 2 Pages: 354-363

    • DOI

      10.9758/cpn.23.1140

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22K07568
  • [Journal Article] Long-term mental health and resilience of the first responders in Japanese ground self-defense forces engaging body recovery after the great east Japan earthquake2024

    • Author(s)
      Maeno Yoshikazu、Fuchikami Manabu、Fujimaki Koichiro、Liberzon Israel、Morinobu Shigeru
    • Journal Title

      Journal of Psychiatric Research

      Volume: 173 Pages: 381-386

    • DOI

      10.1016/j.jpsychires.2024.03.031

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K07568
  • [Journal Article] Examining mechanisms via which traumatic stress leads to posttraumatic stress disorder2022

    • Author(s)
      Knox KD, Sabban EL, Morinobu S
    • Journal Title

      Frontiers in Behavioral Neuroscience

      Volume: 16 Pages: 966147-966147

    • DOI

      10.3389/fnbeh.2022.966147

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K07568
  • [Journal Article] Chemogenetic activation of the mPFC alleviates impaired fear memory extinction in an animal model of PTSD2021

    • Author(s)
      Omura Jun、Fuchikami Manabu、Araki Motoaki、Miyagi Tatsuhiro、Okamoto Yasumasa、Morinobu Shigeru
    • Journal Title

      Progress in Neuro-Psychopharmacology and Biological Psychiatry

      Volume: 108 Pages: 110090-110090

    • DOI

      10.1016/j.pnpbp.2020.110090

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K07562, KAKENHI-PROJECT-18K07575
  • [Journal Article] Alterations in DNA methylation rates of brain-derived neurotrophic factor in patients with schizophrenia2021

    • Author(s)
      Nojima S, Fuchikami M, Kataoka T, Araki M, Omura J, Miyagi T, Okamoto Y, Hishimoto A, Morinobu S
    • Journal Title

      The European Journal of Psychiatry

      Volume: 35 Issue: 2 Pages: 67-74

    • DOI

      10.1016/j.ejpsy.2020.08.003

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K07575
  • [Journal Article] Structural variation in the glycogen synthase kinase 3β and brain-derived neurotrophic factor genes in Japanese patients with bipolar disorders.2020

    • Author(s)
      Suga Y, Yoshimoto K, Numata S, Shimodera S, Takamura S, Kamimura N, Sawada K, Kazui H, Ohmori T, Morinobu S.
    • Journal Title

      Neuropsychopharmacol Rep.

      Volume: 40 Issue: 1 Pages: 46-51

    • DOI

      10.1002/npr2.12083

    • NAID

      120007027667

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18H02751, KAKENHI-PROJECT-17K00206
  • [Journal Article] The role of glucocorticoid receptors in the induction and prevention of hippocampal abnormalities in an animal model of posttraumtic stress disorder2020

    • Author(s)
      Araki M, Fuchikami M, Omura J, Miyagi T, Nagashima N, Okamoto Y, Morinobu S
    • Journal Title

      Psychopharmacology

      Volume: in press Issue: 7 Pages: 2125-2137

    • DOI

      10.1007/s00213-020-05523-x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K07575, KAKENHI-PROJECT-18K07562
  • [Journal Article] The influence of aging on the methylation status of brain-derived neurotrophic factor gene in blood.2018

    • Author(s)
      K. Ihara, M. Fuchikami, M. Hashizume, S. Okada, H. Kawai, S. Obuchi, H. Hirano, Y. Fujiwara, M. Hachisu, H. Kim, S. Morinobu
    • Journal Title

      International Journal of Geriatric Psychiatry

      Volume: 印刷中

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K08824
  • [Journal Article] usical deficits and cortical thickness in people with schizophrenia2018

    • Author(s)
      Fujito R, Minese M, Hatada S, Kamimura N, Morinobu S, Lang DJ, Honer WG, Sawada K.
    • Journal Title

      Schizophr Res

      Volume: 14 Pages: 30049-5

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K00206
  • [Journal Article] Combined brain-derived neurotrophic factor with extinction training alleviate impaired fear extinction in an animal model of post-traumatic stress disorder.2018

    • Author(s)
      Kataoka T, Fuchikami M, Nojima S, Nagashima N, Araki M, Omura J, Miyagi T, Okamoto Y, Morinobu S
    • Journal Title

      Genes Brain & Behavior

      Volume: e12520 Issue: 7 Pages: 1-10

    • DOI

      10.1111/gbb.12520

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K07575
  • [Journal Article] DNAメチル化を用いたうつ病診断バイオマーカーの開発2017

    • Author(s)
      森信繁
    • Journal Title

      生化学

      Volume: 印刷中

    • NAID

      40021119802

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K09810
  • [Journal Article] BDNF遺伝子のDNAメチル化を指標としたうつ病診療2016

    • Author(s)
      淵上学、森信繁
    • Journal Title

      Depression Frontier

      Volume: 2 Pages: 68-76

    • Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K09810
  • [Journal Article] Blood Diagnostic Biomarkers for Major Depressive Disorder using Multiplex DNA Methylation Profiles: Discovery and Validation.2015

    • Author(s)
      Shusuke Numata, Kazuo Ishii, Atsushi Tajima, Jun-Ichi Iga, Makoto Kinoshita, Shinya Watanabe, Hidehiro Umehara, Manabu Fuchikami, Satoshi Okada, Shuken Boku, Akitoyo Hishimoto, Shinji Shimodera, Issei Imoto, Shigeru Morinobu, Tetsuro Ohmori
    • Journal Title

      Epigenetics

      Volume: 10(2) Issue: 2 Pages: 135-141

    • DOI

      10.1080/15592294.2014.1003743

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26330325, KAKENHI-PROJECT-26461718, KAKENHI-PROJECT-26461719, KAKENHI-PROJECT-26461720, KAKENHI-PROJECT-15K09810, KAKENHI-PROJECT-26461768
  • [Journal Article] The potential use of histone deacetylase inhibitors in the treatment of depression2015

    • Author(s)
      Fuchikami M, Morinobu S, et al.
    • Journal Title

      Progress in Neuro-Psychopharmacology & Biological Psychiatry

      Volume: 62 Pages: 00059-7

    • DOI

      10.1016/j.pnpbp.2015.03.010

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PUBLICLY-25116518, KAKENHI-PROJECT-25861036, KAKENHI-PROJECT-15K09810, KAKENHI-PROJECT-15K19731
  • [Journal Article] The potential of SLC6A4 gene methylation analysis for the diagnosis and treatment of major depression2014

    • Author(s)
      Okada S, Morinobu S, et al
    • Journal Title

      Journal of Psychiatric Research

      Volume: 53 Pages: 47-53

    • DOI

      10.1016/j.jpsychires.2014.02.002

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-25116518, KAKENHI-PROJECT-25861009
  • [Journal Article] The potential of SLC6A4 gene methylation analysis for the diagnosis and treatment of major depression2014

    • Author(s)
      Okada S, Morinobu S, Fuchikami M, Segawa M, Yokomaku K, Kataoka T, Okamoto Y, Yamawaki S, Inoue T, Kusumi I, Koyama T, Tsuchiyama K, Trao T, Kokubo Y, Mimura M
    • Journal Title

      J psychiatric Res

      Volume: 53 Pages: 47-53

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659566
  • [Journal Article] The potential of SLC6A4 gene methylation analysis for the diagnosis and treatment of major depression2014

    • Author(s)
      Okada S, Morinobu S, et al
    • Journal Title

      Journal of Psychiatric Research

      Volume: 53 Pages: 47-53

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659566
  • [Journal Article] BDNF遺伝子のメチル化を用いたうつ病バイオマーカーの開発2014

    • Author(s)
      森信 繁
    • Journal Title

      別冊・医学のあゆみ

      Volume: 1 Pages: 148-151

    • Data Source
      KAKENHI-PROJECT-23659566
  • [Journal Article] BDNF遺伝子のメチル化を用いたうつ病バイオマーカーの開発2013

    • Author(s)
      森信繁、淵上学、瀬川昌弘、岡田怜
    • Journal Title

      医学のあゆみ

      Volume: 244 Pages: 508-511

    • Data Source
      KAKENHI-PROJECT-23659566
  • [Journal Article] エピジェネティクスからみたうつ病の病態2013

    • Author(s)
      森信 繁
    • Journal Title

      精神神経学雑誌

      Volume: 115 Pages: 1101-1112

    • NAID

      40019880164

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659566
  • [Journal Article] Resting state low-frequency fluctuations in prefrontal cortex reflect degrees of harm avoidance and novelty seeking: an exploratory NIRS study.2013

    • Author(s)
      Takashi Nakao, Tomoya Matsumoto, Daisuke Shimizu, Machiko Morita, Shinpei Yoshimura, Georg Northoff, Shigeru Morinobu, Yasumasa Okamoto, Shigeto Yamawaki
    • Journal Title

      Frontiers in System Neuroscience

      Volume: 7 Pages: 1-9

    • DOI

      10.3389/fnsys.2013.00115

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24390284, KAKENHI-PROJECT-25780413, KAKENHI-PROJECT-25870467
  • [Journal Article] The degree of early life stress predicts decreased medial prefrontal activations and the shift from internally to externally guided decision making: An exploratory NIRS study during resting state and self-oriented task.2013

    • Author(s)
      Takashi Nakao, Tomoya Matsumoto, Machiko Morita, Daisuke Shimizu, Shinpei Yoshimura, Georg Northoff, Shigeru Morinobu, Yasumasa Okamoto, Shigeto Yamawaki
    • Journal Title

      Frontiers in Human Neuroscience

      Volume: 7 Pages: 1-13

    • DOI

      10.3389/fnhum.2013.00339

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24390284, KAKENHI-PROJECT-25870467
  • [Journal Article] Vorinostat ameliorates impaired fear extinction possibly via the hippocampal NMDA-CaMKII pathway in an animal model of posttraumatic stress disorder.2013

    • Author(s)
      Matsumoto S, Morinobu S, et al
    • Journal Title

      Psychopharmacology

      Volume: 229 Issue: 1 Pages: 51-62

    • DOI

      10.1007/s00213-013-3078-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-25116518
  • [Journal Article] BDNF遺伝子のメチル化を用いたうつ病バイオマーカーの開発2012

    • Author(s)
      岡田怜、淵上学、森信繁
    • Journal Title

      Depression Frontier

      Volume: 10 Pages: 51-57

    • Data Source
      KAKENHI-PROJECT-23659566
  • [Journal Article] うつ病の発症・回復過程とレジリエンス2012

    • Author(s)
      森信繁
    • Journal Title

      臨床精神医学

      Volume: 41 Pages: 175-180

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-23118004
  • [Journal Article] Enhanced hippocampal BDNF/TrkB signaling in response to fear conditioning in an animal model of posttraumatic stress disorder.2011

    • Author(s)
      Takei Shiro, Morinobu Shigeru, Yamamoto Shigeto, Fuchikami Manabu, Matsumoto Tomoya, Yamawaki Shigeto
    • Journal Title

      J Psychiatric Res 45

      Pages: 460-468

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591368
  • [Journal Article] ストレスとうつ病動物モデル2010

    • Author(s)
      森信繁、高橋輝道、山本茂人
    • Journal Title

      別冊・医学のあゆみ

      Pages: 190-195

    • Data Source
      KAKENHI-PROJECT-20591368
  • [Journal Article] Epigenetic regulation of BDNF gene in response to stress.2010

    • Author(s)
      Fuchikami Manabu, Yamamoto Shigeto, Morinobu Shigeru, Takei Shiro, Yamawaki Shigeto
    • Journal Title

      Psychiatry Investigation 7

      Pages: 251-256

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591368
  • [Journal Article] うつ病の新たなメカニズム-エピジェネティクス-2010

    • Author(s)
      森信繁
    • Journal Title

      精神神経学雑誌

      Volume: 112 Pages: 986-991

    • NAID

      10028059807

    • Data Source
      KAKENHI-PROJECT-20591368
  • [Journal Article] Alteration in the hippocampal glycinergic system in an animal model of posttraumatic stress disorder.2010

    • Author(s)
      Yamamoto Shigeto, Morinobu Shigeru, Iwamoto Yasuyuki, Ueda Yuto, Takei Shiro, Fujita Yosuke, Yamawaki Shigeto
    • Journal Title

      J Psychiatric Res 44

      Pages: 1069-1074

    • NAID

      120002753738

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591368
  • [Journal Article] Maternal postpartum learned helplessness (LH) affects maternal care by dams and responses to the LH test in adolescent offspring.2009

    • Author(s)
      Kurata Akiko, Morinobu Shigeru, Fuchikami Manabu, Yamamoto Shigeto, Yamawaki Shigeto
    • Journal Title

      Horm Behav 56

      Pages: 112-120

    • NAID

      120001700471

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591368
  • [Journal Article] Single immobilization stress differentially alters the expression profile of transcripts of the brain-derived neurotrophic factor (BDNF) gene and histone acetylation at its promoters in the rat hippocampus.2009

    • Author(s)
      Fuchikami M, Morinobu S, Kurata A, Yamamoto S, Yamawaki S
    • Journal Title

      Int J Neuropsychopharmacol 12

      Pages: 73-82

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591368
  • [Journal Article] 栄養因子・成長因子とシナプス可塑性からみたうつ病の病態メカニズム2009

    • Author(s)
      森信繁
    • Journal Title

      精神神経学誌 111

      Pages: 687-691

    • NAID

      10026307158

    • Data Source
      KAKENHI-PROJECT-20591368
  • [Journal Article] Effects of Single Prolonged Stress and D-Cycloserine on Contextual Fear Extinction and Hippocampal NMDA Receptor Expression in a Rat Model of PTSD2008

    • Author(s)
      Yamamoto S, Morinobu S, Fuchikami M, Kurata A, Kozuru T, Yamawaki S
    • Journal Title

      Neuropsychopharmacology 33

      Pages: 2108-2116

    • NAID

      120001092440

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18591290
  • [Journal Article] Neonatal tactile stimulation reverses the effect of neonatal isolation on open-field and anxiety-like behavior, and pain sensitivity in male and female adult Sprague-Dawley rats2008

    • Author(s)
      Imanaka A, Morinobu S, Toki S, Yamamoto S, Matsuki A, Kozuru T, Yamawaki S
    • Journal Title

      Behav Brain Res 186

      Pages: 91-97

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18591290
  • [Journal Article] 外傷後ストレス障害(PTSD)の分子病態メカニズム2007

    • Author(s)
      森信 繁
    • Journal Title

      実験医学 25

      Pages: 173-178

    • Data Source
      KAKENHI-PROJECT-18023027
  • [Journal Article] 外傷後ストレス障害(PTSD)の分子病態メカニズム-病態モデル動物を用いた解析から-2007

    • Author(s)
      森信繁, 岩本泰行, 高橋輝道, 小鶴俊郎, 山脇成人
    • Journal Title

      実験医学 25

      Pages: 2067-2072

    • Data Source
      KAKENHI-PROJECT-18591290
  • [Journal Article] 外傷後ストレス障害(PTSD)の分子病態メカニズム2007

    • Author(s)
      森信 繁
    • Journal Title

      実験医学 25

      Pages: 173-178

    • Data Source
      KAKENHI-PROJECT-18591290
  • [Journal Article] Single prolonged stress increases contextual freezing and the expression of glycine transporter 1 and vesicle-associated membrane protein 2 mRNA in the hippocampus of rats2007

    • Author(s)
      Iwamoto Y, Morinobu S, Takahashi T, Yamawaki S
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry 31

      Pages: 642-651

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18591290
  • [Journal Article] 養育の生物学-遺伝子による解明のカギ-2007

    • Author(s)
      土岐 茂, 森信 繁
    • Journal Title

      こころの科学 134(印刷中)

    • Data Source
      KAKENHI-PROJECT-18023027
  • [Journal Article] Importance of early lighting conditions in maternal care by dam as well as anxiety and memory later in lige of offspring2007

    • Author(s)
      Toki, S., Morinobu, S., et al.
    • Journal Title

      Eur J Neurosci. 25・3

      Pages: 815-829

    • Data Source
      KAKENHI-PROJECT-17591214
  • [Journal Article] Importance of early environment in the development of post-traumatic stress disorder-like behaviors.2006

    • Author(s)
      Imanaka A, Morinobu S, Toki S, Yamawaki S
    • Journal Title

      Behav Brain Res 173

      Pages: 129-137

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18591290
  • [Journal Article] 養育環境と精神発達の生物学2006

    • Author(s)
      土岐 茂, 森信 繁
    • Journal Title

      分子精神医学 6・4

      Pages: 35-44

    • Data Source
      KAKENHI-PROJECT-18023027
  • [Journal Article] Nenatal isolation changes the expression of IGF-IR and EGFBP-2 in the hippocampus in response to adul thood restraint stress.2006

    • Author(s)
      Erabi, K., Morinobu, s., et al.
    • Journal Title

      Int J Neuropsychopharmacol. 19

      Pages: 1-13

    • Data Source
      KAKENHI-PROJECT-17591214
  • [Journal Article] ストレスと動物うつ病モデル2006

    • Author(s)
      森信 繁, 他
    • Journal Title

      医学のあゆみ 219・13

      Pages: 1042-1046

    • Data Source
      KAKENHI-PROJECT-18023027
  • [Journal Article] Importance of early environment in the development of post-traumatic stress disorder-like behaviors.2006

    • Author(s)
      Imanaka, A., Morinobu., et al.
    • Journal Title

      Behav Brain Res. 173・1

      Pages: 129-37

    • Data Source
      KAKENHI-PROJECT-17591214
  • [Journal Article] Effect of paroxetine on enhanced contextual fear induced by single prolonged stress in rats2006

    • Author(s)
      Takahashi T, Morinobu S, Iwamoto Y, Yamamwaki S
    • Journal Title

      Psychopharmacology 189

      Pages: 165-173

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18591290
  • [Journal Article] ストレス脆弱性形成の分子機序2005

    • Author(s)
      森信 繁
    • Journal Title

      医学のあゆみ 212

      Pages: 1107-1110

    • Data Source
      KAKENHI-PROJECT-14570925
  • [Journal Article] ストレス脆弱性の脳内分子機構2005

    • Author(s)
      森信 繁
    • Journal Title

      医学のあゆみ 212

      Pages: 1107-1110

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14570925
  • [Journal Article] うつ病の身体療法2005

    • Author(s)
      市村麻衣, 田中和秀, 森信 繁
    • Journal Title

      臨床看護 31

      Pages: 16-21

    • Data Source
      KAKENHI-PROJECT-14570925
  • [Journal Article] Visual emotional stimuli modulation of auditory sensory gating studied by magnetic P50 suppression.2005

    • Author(s)
      Yamashita, H., Okamoto, Y., Morinobu, S., Yamawaki, S., Kahkonen, S.
    • Journal Title

      Eur Arch Psychiatry Clinical Neurosci. 255

      Pages: 99-103

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14390037
  • [Journal Article] Molecular mechanism for the development of stress vulnerability.2005

    • Author(s)
      Morinobu S.
    • Journal Title

      J Clin & Exp Med(Japanese) 212

      Pages: 1107-1110

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14570925
  • [Journal Article] Reduction in levels of amphiphysin 1 mRNA in the hippocampus of aged rats subjected to variable stress.2004

    • Author(s)
      Sawada T, Morinobu S, et al.
    • Journal Title

      Neuroscience 126

      Pages: 461-466

    • Data Source
      KAKENHI-PROJECT-14570925
  • [Journal Article] β-estradiol, dehydroepiandrosterone, and dehydroepiandrosterone sulfate protect against N-Methyl-D-aspartate-induced neurotoxicity in rat hippocampal neurons by different mechanisms.2004

    • Author(s)
      Kurata, K., Takebayashi, M., Morinobu, S., Yamawaki, S.
    • Journal Title

      The Journal of Pharmacology and Experimental Therapeutics. 311

      Pages: 237-245

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14390037
  • [Journal Article] Lithium and protein phosphatases : apoptosis or neurogenesis?2004

    • Author(s)
      Morinobu, S., Kawano, K., Yamawaki, S.
    • Journal Title

      Clinical Neuroscience Research 4

      Pages: 263-269

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14390037
  • [Journal Article] Effect of neonatal isolation on the noradrenergic transduction system in the rat hippocampal slices.2004

    • Author(s)
      Kusaka K, Morinobu S, et al.
    • Journal Title

      Synapse 54

      Pages: 223-232

    • Data Source
      KAKENHI-PROJECT-14570925
  • [Journal Article] Effects of changing from typical to atypical antipsychotic drugs on subjective sleep quality in patients with schizophrenia in a Japanese population.2004

    • Author(s)
      Yamashita, H., Mori, K., Nagao, M., Okamoto, Y., Morinobu, S., Yamawaki, S.
    • Journal Title

      The Journal of Clinical Psychiatry 65

      Pages: 1525-1530

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14390037
  • [Journal Article] Influence of immobilization stress on the levels of CaMKII and phospho-CaMKII in the rat hippocampus.2004

    • Author(s)
      Suenaga T, Morinobu S, et al.
    • Journal Title

      International Journal of Neuropsychopharmacology 7

      Pages: 299-309

    • Data Source
      KAKENHI-PROJECT-14570925
  • [Journal Article] Reduction in levels of amphiphysin 1 mRNA in the hippocampus of aged rats subjected to repeated variable stress.2004

    • Author(s)
      Sawada, T., Morinobu, S., Tsuji, S., Kawano, K., Watanabe, T., Suenaga, T., Takahashi, T., Yamawaki, S., Nishida, A.
    • Journal Title

      Neuroscience 126

      Pages: 461-466

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14390037
  • [Journal Article] Lithium and protein phosphatases : apoptosis or neurogenesis?2004

    • Author(s)
      Morinobu, S.
    • Journal Title

      Clinical Neuroscience Research 4

      Pages: 263-269

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14390037
  • [Journal Article] Effect of neonatal isolation on the noradrenergic transduction system in the rat hippocampal slice.2004

    • Author(s)
      Kusaka, K., Morinobu, S., Kawano, K., Yamawaki, S.
    • Journal Title

      Synapse 54

      Pages: 223-232

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14390037
  • [Journal Article] Influence of immobilization stress on the expression and phosphatase activity of protein phosphatase 2A in the rat brain2003

    • Author(s)
      Morinobu Shigeru
    • Journal Title

      Biol Psychiatry 54

      Pages: 1060-1066

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14570925
  • [Journal Article] Influence of immobilization stress on the expression and phosphatase activity of protein phosphatase2A in the rat brain.2003

    • Author(s)
      Morinobu S.
    • Journal Title

      Biol Psychiatry 54

      Pages: 1060-1066

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14570925
  • [Journal Article] 外傷後ストレス障害(PTSD)の分子病態メカニズム-病態モデル動物を用いた解析から-

    • Author(s)
      森信 繁
    • Journal Title

      実験医学 (印刷中)

    • Data Source
      KAKENHI-PROJECT-18591290
  • [Presentation] 新たなうつ病の病態仮説<Imbalance of excitation-inhibition within the PFC>2019

    • Author(s)
      森信 繁、淵上 学
    • Organizer
      第38回躁うつ病の薬理・生化学的研究懇話会
    • Data Source
      KAKENHI-PROJECT-18K07575
  • [Presentation] Efficacy of lithium and BDNF gene CNV in bipolar disorders2018

    • Author(s)
      Shigeru Morinobu
    • Organizer
      WFSBP Asia Pacific Regional Congress of Biological Psychiatry
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09810
  • [Presentation] GSK3beta, BDNF遺伝子のCNVによる双極性障害のリチウム治療反応性の研究2017

    • Author(s)
      森信繁、須賀楓介、吉本啓一郎、沼田周助、高村祥吾、上村直人、下寺信次、大森哲郎
    • Organizer
      第39回日本生物学的精神医学会・第47回日本神経精神薬理学会合同年会
    • Data Source
      KAKENHI-PROJECT-15K09810
  • [Presentation] 閾値下うつ病に対する行動活性化療法の神経基盤2015

    • Author(s)
      森・岡本他
    • Organizer
      第111回日本精神神経学会学術総会
    • Place of Presentation
      大阪国際会議場(大阪府・大阪市)
    • Year and Date
      2015-06-04
    • Data Source
      KAKENHI-PLANNED-23118004
  • [Presentation] エピジェネティクスからみたうつ病の病態メカニズム2015

    • Author(s)
      森信 繁
    • Organizer
      第12回日本うつ病学会総会
    • Place of Presentation
      京王プラザ、東京
    • Year and Date
      2015-07-17
    • Invited
    • Data Source
      KAKENHI-PROJECT-15K09810
  • [Presentation] メタ認知トレーニング日本語版(MCT-J)満足度評価票の開発2015

    • Author(s)
      石垣琢麿・細野正人・越晴香・森美栄子・石川亮太郎・森重さとり
    • Organizer
      第111回日本精神神経学会学術総会
    • Place of Presentation
      大阪国際会議場(大阪府・大阪市)
    • Year and Date
      2015-06-06
    • Data Source
      KAKENHI-PLANNED-23118004
  • [Presentation] 多彩な体感幻覚症状にsertralineが著効した発作間欠期不快気分障害の1例2015

    • Author(s)
      森田進ら
    • Organizer
      第111回日本精神神経学会学術総会
    • Place of Presentation
      大阪国際会議場(大阪府・大阪市)
    • Year and Date
      2015-06-06
    • Data Source
      KAKENHI-PLANNED-23118004
  • [Presentation] Searching for epigenetic biomarkers in PTSD2014

    • Author(s)
      Morinobu S
    • Organizer
      VI Japanese Society of Anxiety Disorder Academic Conference
    • Place of Presentation
      Tokyo Univ, Tokyo
    • Data Source
      KAKENHI-PROJECT-23659566
  • [Presentation] 安静時脳機能磁気共鳴画像を用いた機械学習による自閉症スペクトラム障害の神経基盤研究2014

    • Author(s)
      八幡憲明、森本淳、橋本龍一郎、柴田和久、今水寛、福田めぐみ、川久保友紀、桑原斉、黒田美保、山田貴志、加藤進昌、佐々木由香、渡邊武郎、笠井清登、川人光男
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜神奈川県横浜市
    • Year and Date
      2014-09-24
    • Data Source
      KAKENHI-PLANNED-23118004
  • [Presentation] 異なる金額の報酬/罰に対する脳内報酬系の活動性の変化2014

    • Author(s)
      森 麻子、岡本泰昌ほか
    • Organizer
      第11回うつ病学会総会
    • Place of Presentation
      広島国際会議場(広島県広島市)
    • Year and Date
      2014-07-18
    • Data Source
      KAKENHI-PLANNED-23118004
  • [Presentation] DNA methylation profiles of the brain-derived neurotrophic factor gene as a potent diagnostic biomarker in major depression2013

    • Author(s)
      Morinobu S, et al
    • Organizer
      21th Worlld Congress of Psychiatry Genetics
    • Place of Presentation
      Boston, USA
    • Data Source
      KAKENHI-PROJECT-23659566
  • [Presentation] Age at onset of exercise affects locomotor ability and survival of lumbar motoneurons in aged rats2013

    • Author(s)
      Takemoto H, Kanemura N, Imagita H, Okada K, Yamakami T, Kawata S, Koichiro Fujimaki K, Matsumoto T, Murata K, Kokubun T, Kataoka T, Deie M, Otsuka A, Oki S, Morinobu S
    • Organizer
      The 43nd Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      San Diego
    • Year and Date
      2013-11-11
    • Data Source
      KAKENHI-PROJECT-23500604
  • [Presentation] Searching for epigenetic biomarkers in major depression : focusing on the sero tonin signal transduction2013

    • Author(s)
      Segawa M, Morinobu S, Fuchikami M, Fujita Y, Okada S, Okamoto Y, Yamawaki S
    • Organizer
      XXI World Congress of Psychiatric Genetics
    • Place of Presentation
      Seaport World Trade Center and Seaport Hotel, Boston USA
    • Data Source
      KAKENHI-PROJECT-23659566
  • [Presentation] DNA methylation profiles of the brain-derived neurotrophic factor gene as a potent diag nostic biomarker in major depression2013

    • Author(s)
      Morinobu S, Fuchikami M, Segawa M, Okada S, Okamoto Y, Yamawaki S
    • Organizer
      XXI World Congress of Psychiatric Genetics
    • Place of Presentation
      Seaport World Trade Center and Seaport Hotel, Boston USA
    • Data Source
      KAKENHI-PROJECT-23659566
  • [Presentation] Possibility of DNA methyl ation profiles as a potent diagnostic biomarker in PTSD2013

    • Author(s)
      Morinobu S
    • Place of Presentation
      Kyoto International Conference Center, Kyoto Japan
    • Data Source
      KAKENHI-PROJECT-23659566
  • [Presentation] Searching for epigenetic biomarkers in major depression: focusing on the serotonin signal transduction2013

    • Author(s)
      Segawa M, Morinobu S, et al
    • Organizer
      21th Worlld Congress of Psychiatry Genetics
    • Place of Presentation
      Boston, USA
    • Data Source
      KAKENHI-PROJECT-23659566
  • [Presentation] DNA methylation profiles of the brain-derived neurotrophic factor (BDNF) gene as a potent diagnostic biomarker in psychiatric disorders2012

    • Author(s)
      Okada S, Morinobu S, Fuchikami M, Yamawaki S
    • Organizer
      Neuro2012
    • Place of Presentation
      New Orleans (USA)
    • Data Source
      KAKENHI-PROJECT-23659566
  • [Presentation] DNA メチル化解析を用いた精神疾患の客観的診断法の開発2012

    • Author(s)
      森信 繁
    • Organizer
      第34回日本生物学的精神医学会
    • Place of Presentation
      神戸ポートピア国際会議場, 神戸
    • Data Source
      KAKENHI-PROJECT-23659566
  • [Presentation] DNA methylation profiels of the brain-derived neurotrophic factor (BDNF) gene as a potent diagnostic biomarker in psychiatric disorders2012

    • Author(s)
      Okada S, Morinobu S, Fuchikami M, Yamawaki S
    • Organizer
      Neuroscience 2012
    • Place of Presentation
      New Orleans Convention Center,New Orleans, USA
    • Data Source
      KAKENHI-PROJECT-23659566
  • [Presentation] Searching for epigenetic biomarkers in PTSD2012

    • Author(s)
      Morinobu S, Fuchikami M, Okada S, Yamawaki S, Liberzon I, King A, Seng J
    • Organizer
      28th CINP
    • Place of Presentation
      Stockholm (Sweden)
    • Invited
    • Data Source
      KAKENHI-PROJECT-23659566
  • [Presentation] エピジェネティクスからみたうつ病の病態・診断・治療2012

    • Author(s)
      森信 繁
    • Organizer
      第31回日本認知症学会
    • Place of Presentation
      つくば国際会議場, つくば
    • Data Source
      KAKENHI-PROJECT-23659566
  • [Presentation] Are the DNA methylation profiels within theCpG island at the promoter of exon1 of the brain-derived neurotrophic factor (BDNF) gene a potent diagnostic biomarker in psychiatric disorders?2011

    • Author(s)
      Morinobu S
    • Organizer
      34th Annual Meeting of the Japan Neuroscience Society(招待講演)
    • Place of Presentation
      Yokohama
    • Data Source
      KAKENHI-PROJECT-23659566
  • [Presentation] DNA メチル化解析を用いた精神疾患の客観的診断法の開発2011

    • Author(s)
      森信 繁
    • Organizer
      第33回日本臨床薬理学会
    • Place of Presentation
      沖縄コンベンションセンター,沖縄
    • Data Source
      KAKENHI-PROJECT-23659566
  • [Presentation] Enhanced transcription of the BDNF gene and histone acetylation at its promoters are involved in fear memory consolidation in an animal model of PTSD2010

    • Author(s)
      Takei shiro, Morinobu Shigeru, Yamamoto Shigeto, Fuchikami Manabu, Yamawaki Shigeto
    • Organizer
      CINP2010
    • Place of Presentation
      Hong Kong, China
    • Data Source
      KAKENHI-PROJECT-20591368
  • [Presentation] うつ病発症の新たなメカニズム-エピジェネティクス-2010

    • Author(s)
      森信繁
    • Organizer
      第106回日本精神神経学会
    • Place of Presentation
      広島
    • Data Source
      KAKENHI-PROJECT-20591368
  • [Presentation] Electroconvulsive seizure induced tissue-plasminogen activator (t-PA) expression in rat hippocampus.2010

    • Author(s)
      Segawa Masahiro, Fuchikami Manabu, Matsumoto Tomoya, Morinobu Shigeru, Yamawaki Shigeto
    • Organizer
      Neuro2010
    • Place of Presentation
      San Diego, U.S.A.
    • Data Source
      KAKENHI-PROJECT-20591368
  • [Presentation] The effect of the histone deacetylase inhibitor Suberoylanilide hydroximic acid (SAHA) on extinction of conditioned fear.2010

    • Author(s)
      Fujita Yosuke, Morinobu Shigeru, Takei Shiro, Yamamoto Shigeto, Yamawaki Shigeto
    • Organizer
      Neuro2010
    • Place of Presentation
      San Diego, U.S.A.
    • Data Source
      KAKENHI-PROJECT-20591368
  • [Presentation] 養育環境の修飾によるうつ病動物モデル作成の可能性について2010

    • Author(s)
      森信繁
    • Organizer
      第32回日本生物学的精神医学会
    • Place of Presentation
      北九州
    • Data Source
      KAKENHI-PROJECT-20591368
  • [Presentation] PTSD動物モデルからみた恐怖記憶の障害の脳内メカニズム2009

    • Author(s)
      森信繁
    • Organizer
      第82回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2009-03-17
    • Data Source
      KAKENHI-PROJECT-18591290
  • [Presentation] 産後早期の母ラットにおける学習性無力が養育行動及び仔のストレス脆弱性に与える影響2009

    • Author(s)
      倉田明子、森信繁、淵上学、山本茂人、松木文、山脇成人
    • Organizer
      第31回日本生物学的精神医学会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-20591368
  • [Presentation] Enhanced transcription of the BDNF gene and histone acetylation at its promoters are involved in fear memory consolidation in an animal model of PTSD2009

    • Author(s)
      Morinobu Shigeru, Takei Shiro, Yamamoto Shigeto, Fuchikami Manabu, Yamawaki Shigeto
    • Organizer
      Neuro2009
    • Place of Presentation
      Chicago, U.S.A.
    • Data Source
      KAKENHI-PROJECT-20591368
  • [Presentation] Epigenetic regulation of the BDNF gene and the pathophysiology of depression2009

    • Author(s)
      Morinobu S
    • Organizer
      1st Meeting of the Asian College of Neuropsychopharmacology
    • Place of Presentation
      Kyoto
    • Year and Date
      2009-11-13
    • Data Source
      KAKENHI-PROJECT-20023021
  • [Presentation] Neonatal isolation as an animal model of vulnerability for depression2009

    • Author(s)
      Morinobu S
    • Organizer
      32th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      名古屋
    • Year and Date
      2009-09-18
    • Data Source
      KAKENHI-PROJECT-20591368
  • [Presentation] 新規抗うつ薬開発のためのヒストン修飾を介した抗うつ薬効果の行動学的・分子生物学的研究2009

    • Author(s)
      森信繁
    • Organizer
      第42回精神神経系薬物療法研究報告会
    • Place of Presentation
      豊中市
    • Year and Date
      2009-12-04
    • Data Source
      KAKENHI-PROJECT-20659182
  • [Presentation] The influence of learned helplessnss (LH) in dams dirung early postpartum period on their maternal care and the response to LH test in their adolscent offspring.2008

    • Author(s)
      倉田明子, 森信繁, 淵上学, 山本茂人, 山脇成人
    • Organizer
      Neuro2008
    • Place of Presentation
      Washington D.C., U.S.A.
    • Data Source
      KAKENHI-PROJECT-20591368
  • [Presentation] 栄養因子・成長因子とシナプス可塑性からみたうつ病の病態メカニズム2008

    • Author(s)
      森信繁
    • Organizer
      第104回日本精神神経学会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-20591368
  • [Presentation] うつ病発症感受性と養育環境2008

    • Author(s)
      森信繁、倉田明子、淵上学、松木文、土岐茂、山脇成人
    • Organizer
      第49回日本心身医学会総会
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-20591368
  • [Presentation] Neonatal isolation induces susceptibility to leaned helplessness through the decrease in LIMK1 in the adult rat hippocampus2007

    • Author(s)
      Shigeru Morinobu
    • Organizer
      Neuroscience 2007
    • Place of Presentation
      San Diego
    • Year and Date
      2007-11-05
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17591214
  • [Presentation] 外傷後ストレス障害動物モデルと記憶の消去機能の障害2006

    • Author(s)
      森信繁
    • Organizer
      第29回日本神経科学大会
    • Place of Presentation
      京都
    • Year and Date
      2006-07-19
    • Data Source
      KAKENHI-PROJECT-18591290
  • [Presentation] 幼若期ストレスと内側前頭の活動及び意思決定スタイルとの関連

    • Author(s)
      中尾敬、松本知也、森田真智子、清水大輔、吉村晋平、Georg Northoff、森信繁、岡本泰昌、山脇成人
    • Organizer
      日本認知心理学会第12回大会
    • Place of Presentation
      仙台国際センター(宮城県・仙台市)
    • Year and Date
      2014-06-28 – 2014-06-29
    • Data Source
      KAKENHI-PROJECT-24390284
  • [Presentation] 地域思春期コホート Tokyo TEEN Cohortの立ち上げ

    • Author(s)
      安藤俊太郎、西田敦志、山崎修道、森本裕子、小池進介、菊次彩、藤川慎也、金田渉、杉本徳子、鳥山理恵、長谷川眞理子、笠井清登
    • Organizer
      第17回日本精神保健・予防学会学術集会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PLANNED-23118004
  • [Presentation] PTSD動物モデルであるSPS負荷ラット海馬のspine障害についての解析

    • Author(s)
      森信 繁、ほか
    • Organizer
      第45回日本神経精神薬理学会
    • Place of Presentation
      東京(京王プラザホテル)
    • Year and Date
      2015-09-24 – 2015-09-26
    • Data Source
      KAKENHI-PUBLICLY-25116518
  • [Presentation] PTSDの病態形成過程におけるGlucocorticoid受容体(GR)活性化を介したBcl-2/Bax遺伝子の発現変化の検討

    • Author(s)
      長嶋信行、森信 繁、ほか
    • Organizer
      第37回日本生物学的精神医学会
    • Place of Presentation
      東京(京王プラザホテル)
    • Year and Date
      2015-09-24 – 2015-09-26
    • Data Source
      KAKENHI-PUBLICLY-25116518
  • 1.  YAMAWAKI Shigeto (40230601)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 9 results
  • 2.  KAWAKATSU Shinobu (00211178)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 3.  淵上 学 (40403571)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 9 results
  • 4.  TOTSUKA Shiro (80009133)
    # of Collaborated Projects: 3 results
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  • 5.  OKAMOTO Yasumasa (70314763)
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    # of Collaborated Products: 7 results
  • 6.  IHARA Kazushige (10266083)
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    # of Collaborated Products: 1 results
  • 7.  KAGAYA Ariyuki (60274065)
    # of Collaborated Projects: 2 results
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    # of Collaborated Projects: 1 results
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    # of Collaborated Projects: 1 results
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  • 16.  TAKEMOTO Hidenori (10453218)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 17.  KANEMURA Naohiko (20379895)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 18.  FUJIMAKI Koichiro (50324570)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 19.  IMAGITA Hidetaka (00412148)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 20.  YOSHINO Atsuo (90633727)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  NAKAO Takashi (40432702)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 22.  YAMASAHITA Hidehisa (50294591)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  Sakai Norio (70263407)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  HIDE IZUMI (20253073)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  TANAKA SHIGERU (20512651)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  SHIRAFUJI TOSHIHIKO (30595765)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 27.  Kasai Kiyoto (80322056)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 28.  TANAKA Satoshi (00456675)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 29.  YAMAZAKI Syudo (10447401)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 30.  MURAI Toshiya (30335286)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 31.  YAHATA Noriaki (70409150)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 32.  TAKIZAWA Ryu (30420243)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 33.  ISHIGAKI Takuma (70323920)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 34.  TAKEBAYASHI Minoru (60304440)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 35.  MIYATA Jun (90549099)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 36.  FUKUI Hiroki (40455415)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 37.  OZAKI Norio (40281480)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 38.  KAMIMURA Naoto (10315004)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 39.  篠原 正夫 (40187381)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 40.  福田 浩 (40325171)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 41.  西村 幸香 (60456738)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 42.  赤松 正規 (10527592)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 43.  下寺 信次 (20315005)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 44.  池田 学 (60284395)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 45.  篠森 敬三 (60299378)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 46.  谷向 知 (90361336)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 47.  津田 雅之 (90406182)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 48.  飛田 秀樹 (00305525)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 49.  安原 隆雄 (50457214)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 50.  亀田 雅博 (50586427)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 51.  中路 重之 (10192220)
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    # of Collaborated Products: 0 results
  • 52.  谷澤 薫平 (50771812)
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    # of Collaborated Products: 0 results
  • 53.  岩本 和也 (40342753)
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    # of Collaborated Products: 0 results
  • 54.  岡田 怜 (70740207)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 55.  YAMAMOTO Shigeto
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    # of Collaborated Products: 2 results
  • 56.  SHIRO Takei
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 57.  IWAMOTO Yasuyuki
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 58.  IMANAKA Akihiro
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 59.  MATSUKI Aya
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 60.  川 勝忍
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 61.  NUMATA Shusuke
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 62.  大森 哲郎
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 63.  石井 一夫
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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