NISHIGUCHI Tomizo 西口富三

… Alternative Names

KOBAYASHI Takao 西口富三

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Researcher Number	30198452
External Links
Affiliation (based on the past Project Information) *help	2001 – 2006: Hamamatsu Univ. Sch. Of Med., Obstet. Gynecol., Assistant Prof., 医学部附属病院, 講師 2004: Hamamatsu University School of Medicine, lecturer, 医学部附属病院, 講師 2002: 浜松医科大学, 医学部付属病院, 講師 1999 – 2001: 浜松医科大学, 医学部・附属病院, 講師 1995 – 1998: 浜松医科大学, 医学部, 助手 1991: Hamamatsu Univ. Sch. of Med. Dept. of Obsl. & Gynecol. Assistant 1989 – 1991: 浜松医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Obstetrics and gynecology / Obstetrics and gynecology Except Principal Investigator Obstetrics and gynecology / Obstetrics and gynecology
Keywords	Principal Investigator D-Dimer FDP / AT III / Coagulation Index / Clinical Index / PIVKA-11 / postpartum / PTVKA / protein S / protein C / venous thromboembolism … More / DVT / PIVKA-PC / HepG2 / HUVEC / 肥満 / APC感受性 / 血栓症 / PIVKA-II / 産褥 / PIVKA / プロテインS / プロテインC / 静脈血栓症 / anticoagulant therapy / alpha_2 antiplasmin-plasmin complex (PIC) / chronic DIC / preeclampsia / Plasminogen activator inhibitor 2(PAI2) / Plasminogen activator inhibitor 1(PAI-1) / APC-α_1AT coplex / Protein S / α_2-Antiplasmin-Plasmin complex(PIC) / Throbin-ATIII complex(TAT) / Protein C activation peptide(PCP) / proteinuria / edema / Canonical correlation analysis / Dーdimer FDP / α_2ーantiplasminーplasmin complex(PIC) / ATIII療法 / Gestosis Index(GI) / DーDimer FDP / α_2ーAntiplasminーPlasmin complex / 抗凝固療法 / DーDime FDP / α_2 antiplasminーplasmin complex(PIC) / ATIII / 慢性DIC / 妊娠中毒症 … More Except Principal Investigator 遺伝子治療 / 癌転移抑制 / 転移 / 浸潤 / 卵巣癌 / 胎盤 / 酸素動態 / 近赤外線 / Bikunin / Gene Therapy / Ovarian Cancer / ビクニン / transabdominal monitaring / uterus / placenta / oxygenation / near-infrared spectroscopy (NIRS) / 筋赤外線 / 胎児情報 / 酸素 / 子宮収縮 / 子宮筋 / ヘモグロビン / Gene therapy / Cancer Invasion / Anti-metastatic agent / Metastasis / EPIDURAL ANESTHESIA / SYMPATHETIC NERVE / ANGIOSPASTIC SYNDROME / MR ANGIOGRAPHY / HYPERCOAGULABILITY / VASOSPASMS / PREECLAMPSIA / カテコールアミン / Shear stress / 血管攣縮 / HELLP症候群 / 子癇 / 重症妊娠中毒症 / ATIII(アンチトロビンIII) / トロンビン / カテコラミン / 左腎静脈 / 腹部交感神経節 / Angiospastic syndrome / 持続硬膜外麻酔 / 交感神経 / 内因性トロンビン / 血液凝固異常 / MR angiography / 妊娠血管攣縮症候群 / 妊娠中毒症 / metastasis / invasion / ovarian cancer / 酸素濃度 / 母体腹壁 / 胎児 Less

Development of non-invasive transabdominal monitoring of fetal oxygen status
- Principal Investigator
  
  KANAYAMA Naohiro
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Hamamatsu University School of Medicine
Investigation on the mechanism of deep vein thrombosis during postpartum periodPrincipal Investigator
- Principal Investigator
  
  NISHIGUCHI Tomizo
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Hamamatsu University School of Medicine
Instrument for measuring intrauterine oxygen metabolism using optical technique.
- Principal Investigator
  
  KANAYAMA Naohiro
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Hamamatsu University School of Medicine
Gene Therapy for Ovarian Cancer by Bikunin
- Principal Investigator
  
  KOBAYASHI Hiroshi
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Hamamatsu University School of Medicine
Anti-metastatic gene therapy by human amniotic fluid-derived bikunin
- Principal Investigator
  
  KOBAYASHI Hiroshi
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Hamamatsu University School of Medicine
STUDY ON THE PATHOPHYSIOLOGY OF PREECLAMPSIA : THE MECHANISM OF VASOSPASMS
- Principal Investigator
  
  KOBAYASHI Takao
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  HAMAMATSU UNIVERSITY SCHOOL OF MEDECINE
Production and characterization of newly developed anti-metastatic agents
- Principal Investigator
  
  KOBAYASHI Hiroshi
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  HAMAMATSU UNIV.SCH.OF MED.
A study of coagulation and fibrinolysis abnormalities in preeclamptic patients.Principal Investigator
- Principal Investigator
  
  KOBAYASHI Takao, KOBAYASHI Takao
- Project Period (FY)
  1989 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Hamamatsu University School of Medicine

All 2007 2005 2004 2002

All Journal Article

[Journal Article] Sugimura M, Sumimoto K, Kanayama N : Measurement of placental oxygenation by transabdominal near-infrared spectroscopy2007
- Author(s)
  Kawamura T, Kakogawa J, Takeuchi Y, Takani S, Kimura S, Nishiguchi T.
- Journal Title
  
  Am J Perinatol 24(3)
  
  Pages: 161-166
- Data Source
  KAKENHI-PROJECT-18390445
[Journal Article] Congenital blood coagulation factor XIII deficiency a nd successful deliveries : A review of the literature2007
- Author(s)
  Asahina T, Kobayashi T, Takeuchi K, Katayama T, Kanayama N
- Journal Title
  
  Obstet Gynecol Surv 62(4)
  
  Pages: 255-260
- Data Source
  KAKENHI-PROJECT-18390445
[Journal Article] Overexpression of a hybrid gene consisting of the amino-terminal fragment of urokinase and carboxyl-terminal domain of bikunin suppresses invasion and migration of human ovarian cancer cells in vitro.2005
- Author(s)
  Takei Y, Mizukami H, Saga Y, Kobayashi H, Suzuki M, Matsushita T, Ozawa K, Suzuki M.
- Journal Title
  
  Int J Cancer. 113(1)
  
  Pages: 54-58
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571553
[Journal Article] Bikunin suppresses lipopolysaccharide-induced lethality through down-regulation of tumor necrosis factor-alpha and interleukin-1beta in macrophages.2005
- Author(s)
  Wakahara K, Kobayashi H, Yagyu T, Matsuzaki H, Kondo T, Kurita N, Sekino H, Inagaki K, Suzuki M, Kanayama N, Terao T.
- Journal Title
  
  J.Infect.Dis. 191
  
  Pages: 930-938
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571553
[Journal Article] Overexpression of a hybrid gene consisting of the amino-terminal fragment of urokinase and carboxyl-terminal domain of bikunin suppresses invasion and migration of human ovarian cancer cells in vitro.2005
- Author(s)
  Takei Y, Mizukami H, Saga Y, Kobayashi H, Suzuki M, Matsushita T, Ozawa K, Suzuki M.
- Journal Title
  
  Int J Cancer. 113
  
  Pages: 54-58
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571553
[Journal Article] A Soybean Kunitz Trypsin Inhibitor Suppresses Ovarian Cancer a Cell Invasion by Blocking Urokinase Upregulation.2004
- Author(s)
  Kobayashi H
- Journal Title
  
  Clin.Exp.Metastasis 21
  
  Pages: 159-166
- Data Source
  KAKENHI-PROJECT-14571553
[Journal Article] Upregulation of bikunin in tumor-infiltrating macrophages as a factor of favorable prognosis in ovarian cancer.2004
- Author(s)
  Yoshiko Tanaka, Hiroshi Kobayashi, Mika Suzuki, Naohiro Kanayama, Mitsuaki Suzuki, Toshihiko Terao.
- Journal Title
  
  Gynecologic Oncology 94(3)
  
  Pages: 725-734
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571553
[Journal Article] 妊娠産褥期における母体血中PIVKA II値の推移2004
- Author(s)
  西口富三
- Journal Title
  
  日本産婦人科・新生児血液学会誌 14.1
  
  Pages: 65-66
- NAID
  10019221146
- Data Source
  KAKENHI-PROJECT-16591653
[Journal Article] Therapeutic efficacy of once-daily oral administration of a Kunitz-type protease inhibitor, bikunin, in a mouse model and in human cancer.2004
- Author(s)
  Kobayashi H, Yagyu T, Inagaki K, Kondo T, Suzuki M, Kanayama N, Terao T.
- Journal Title
  
  Cancer. 100(4)
  
  Pages: 869-877
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571553
[Journal Article] Bikunin inhibits lipopolysaccharide-induced tumor necrosis factor alpha induction in macrophages.2004
- Author(s)
  Matsuzaki H, Kobayashi H, Yagyu T, Wakahara K, Kondo T, Kurita N, Sekino H, Inagaki K, Suzuki M, Kanayama N, Terao T.
- Journal Title
  
  Clin.Diag.Lab.Immunol. 11
  
  Pages: 1140-1147
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571553
[Journal Article] Therapeutic efficacy of once-daily oral administration of a Kunitz-type protease inhibitor, bikunin, in a mouse model and in human cancer.2004
- Author(s)
  Kobayashi H
- Journal Title
  
  Cancer 100
  
  Pages: 869-877
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14571553
[Journal Article] Inhibition of Tumor Invasion by Genomic Downregulation of Matriptase Through Suppression of Activation of Receptor-bound Pro-Urokinase.2004
- Author(s)
  Suzuki M, Kobayashi H, Kanayama N, Saga Y, Suzuki M, Lin C-Y, Dickson RB, Terao T.
- Journal Title
  
  J.Biol.Chem. 279(15)
  
  Pages: 14899-14908
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571553
[Journal Article] Suppressing effects of dietary supplementation of soybean trypsin inhibitor on spontaneous, experimental and peritoneal disseminated metastasis in mouse model.2004
- Author(s)
  Kobayashi H, Fukuda Y, Yoshida R, Kanada Y, Nishiyama S, Suzuki M, Kanayama N, Terao T.
- Journal Title
  
  Int.J.Cancer. 112
  
  Pages: 519-524
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571553
[Journal Article] Bikunin Plus Paclitaxel Markedly Reduces Tumor Burden and Ascites in Mouse Model of Ovarian Cancer.2004
- Author(s)
  Kobayashi H
- Journal Title
  
  Int.J.Cancer 110
  
  Pages: 134-139
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14571553
[Journal Article] Bikunin Plus Paclitaxel Markedly Reduces Tumor Burden and Ascites in Mouse Model of Ovarian Cancer.2004
- Author(s)
  Kobayashi H, Yagyu T, Inagaki K, Kondo T, Suzuki M, Kanayama N, Terao T.
- Journal Title
  
  Int.J.Cancer 110(1)
  
  Pages: 134-139
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571553
[Journal Article] Suppressing effects of dietary supplementation of soybean trypsin inhibitor on spontaneous, experimental and peritoneal disseminated metastasis in mouse model.2004
- Author(s)
  Kobayashi H
- Journal Title
  
  Int.J.Cancer 112
  
  Pages: 519-524
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14571553
[Journal Article] Transforming growth factor-beta 1-dependent urokinase up-regulation and promotion of invasion are involved in Src-MAPK-dependent signaling in human ovarian cancer cells.2004
- Author(s)
  Tanaka Y, Kobayashi H, Suzuki M, Kanayama N, Terao T.
- Journal Title
  
  J Biol Chem. 279(10)
  
  Pages: 8567-8576
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571553
[Journal Article] Genetic down-regulation of phosphoinositide-3-kinase by Bikunin correlates with suppression of invasion and metastasis in human ovarian cancer HRA cells.2004
- Author(s)
  Kobayashi H
- Journal Title
  
  J Biol Chem. 279
  
  Pages: 6371-6379
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14571553
[Journal Article] Genetic downregulation of pregnancy-associated plasma protein-A (PAPP-A) by bikunin reduces IGF-I-dependent Akt and ERK1/2 activation and subsequently reduces ovarian cancer cell growth, invasion and metastasis.2004
- Author(s)
  Tanaka Y, Kobayashi H, Suzuki M, Hirashima Y, Kanayama N, Terao T.
- Journal Title
  
  Int J Cancer. 109(3)
  
  Pages: 336-347
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571553
[Journal Article] A Soybean Kunitz Trypsin Inhibitor Suppresses Ovarian Cancer Cell Invasion by Blocking Urokinase Upregulation.2004
- Author(s)
  Kobayashi H
- Journal Title
  
  Clin.Exp.Metastasis 21
  
  Pages: 159-166
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14571553
[Journal Article] A soybean Kunitz trypsin inhibitor suppresses ovarian cancer cell invasion by blocking urokinase upregulation.2004
- Author(s)
  Kobayashi H, Suzuki M, Kanayama N, Terao T.
- Journal Title
  
  Clin Exp Metastasis. 21(2)
  
  Pages: 159-166
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571553
[Journal Article] Genetic down-regulation of phosphoinositide-3-kinase by Bikunin correlates with suppression of invasion and metastasis in human ovarian cancer HRA cells.2004
- Author(s)
  Kobayashi H, Suzuki M, Kanayama N, Terao T.
- Journal Title
  
  J Biol Chem. 279(8)
  
  Pages: 6371-6379
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571553
[Journal Article] A kunitz-type protease inhibitor bikunin disrupts ligand-induced oligomerization of receptors for transforming growth factor (TGF)-β and subsequently suppresses TGF-β signalings.2004
- Author(s)
  Tatsuo Yagyu, Hiroshi Kobayashi, Kiyoshi Wakahara, Hidenori Matsuzaki, Toshiharu Kondo, Noriyuki Kurita, Hideo Sekino, Kiyokazu Inagaki, Mika Suzuki, Naohiro Kanayama, Toshihiko Terao.
- Journal Title
  
  FEBS Lett. 576
  
  Pages: 408-416
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571553
[Journal Article] Transforming growth factor-beta1-dependent activation of Smad2/3 and up-regulation of PAI-1 expression is negatively regulated by Src in SKOV-3 human ovarian cancer cells.2004
- Author(s)
  Wakahara K, Kobayashi H, Yagyu T, Matsuzaki H, Kondo T, Kurita N, Sekino H, Inagaki K, Suzuki M, Kanayama N, Terao T.
- Journal Title
  
  J Cell Biochem. 93(3)
  
  Pages: 437-453
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571553
[Journal Article] Reproductive failure in mice lacking inter-alpha-trypsin inhibitor (ITI)-ITI target genes in mouse ovary identified by microarray analysis.2004
- Author(s)
  Suzuki M, Kobayashi H, Tanaka Y, Kanayama N, Terao T.
- Journal Title
  
  J.Endocrinol. 183
  
  Pages: 29-38
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571553
[Journal Article] A Soybean Kunitz Trypsin Inhibitor Suppresses Ovarian Cancer Cell Invasion by Blocking Urokinase Upregulation.2004
- Author(s)
  Kobayashi H, Suzuki M, Kanayama N, Terao T.
- Journal Title
  
  Clin.Exp.Metastasis 21(2)
  
  Pages: 159-166
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571553
[Journal Article] Alteration of integrins under hypoxic stress in early placenta and choriocarcinoma cell line BeWo.2004
- Author(s)
  Iwaki T, Matsuura T, Sugimura M, Kobayashi T, Kanayama N.
- Journal Title
  
  Gynecol Obstet Invest 57
  
  Pages: 196-203
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370529
[Journal Article] Increased expression of vascular endothelial growth factor in placentas of p57^<Kip2> null embryos.2002
- Author(s)
  Matsuura T, Takahashi K, Nakayama K, Kobayashi T, Choi-Miura N, Tomita M, Kanayama N.
- Journal Title
  
  FEBS Lett. 532
  
  Pages: 283-288
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370529
[Journal Article] Deficiency in p57^<Kip2> expression induces preeclampsia-like symptoms in mice.2002
- Author(s)
  Kanayama N, Takahashi K, Matsuura T, Sugimura M, Kobayashi T, Moniwa N, Tomita M, Nakayama K
- Journal Title
  
  Mol Hum Reprod 8
  
  Pages: 1129-1135
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370529

1. KANAYAMA Naohiro (70204550)

# of Collaborated Projects: 5 results

# of Collaborated Products: 4 results
2. SUGIMURA Motoi (30273189)

# of Collaborated Projects: 4 results

# of Collaborated Products: 2 results
3. SUMIMOTO Kazuhiro (30126817)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
4. KOBAYASHI Hiroshi (40178330)

# of Collaborated Projects: 3 results

# of Collaborated Products: 23 results
5. KOBAYASHI Takao (20107808)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. TERAO Toshihiko (60022852)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. SUZUKI Mitsuaki (50110870)

# of Collaborated Projects: 2 results

# of Collaborated Products: 17 results
8. 茂庭將彦 (00230053)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. TOKUNAGA Naoki (20283369)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. OOI Hidekazu (10283368)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 河村隆一 (90397422)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 竹内欽哉 (80362193)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 須床和恵 (40343199)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

NISHIGUCHI Tomizo 西口 富三

KOBAYASHI Takao 西口 富三

Research Projects

Research Products

Co-Researchers

Development of non-invasive transabdominal monitoring of fetal oxygen status

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation on the mechanism of deep vein thrombosis during postpartum periodPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Instrument for measuring intrauterine oxygen metabolism using optical technique.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Gene Therapy for Ovarian Cancer by Bikunin

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Anti-metastatic gene therapy by human amniotic fluid-derived bikunin

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

STUDY ON THE PATHOPHYSIOLOGY OF PREECLAMPSIA : THE MECHANISM OF VASOSPASMS

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Production and characterization of newly developed anti-metastatic agents

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A study of coagulation and fibrinolysis abnormalities in preeclamptic patients.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Sugimura M, Sumimoto K, Kanayama N : Measurement of placental oxygenation by transabdominal near-infrared spectroscopy2007

Author(s)

Journal Title

Data Source

[Journal Article] Congenital blood coagulation factor XIII deficiency a nd successful deliveries : A review of the literature2007

Author(s)

Journal Title

Data Source

[Journal Article] Overexpression of a hybrid gene consisting of the amino-terminal fragment of urokinase and carboxyl-terminal domain of bikunin suppresses invasion and migration of human ovarian cancer cells in vitro.2005

Author(s)

Journal Title

Description

Data Source

[Journal Article] Bikunin suppresses lipopolysaccharide-induced lethality through down-regulation of tumor necrosis factor-alpha and interleukin-1beta in macrophages.2005

Author(s)

Journal Title

Description

Data Source

[Journal Article] Overexpression of a hybrid gene consisting of the amino-terminal fragment of urokinase and carboxyl-terminal domain of bikunin suppresses invasion and migration of human ovarian cancer cells in vitro.2005

Author(s)

Journal Title

Description

Data Source

[Journal Article] A Soybean Kunitz Trypsin Inhibitor Suppresses Ovarian Cancer a Cell Invasion by Blocking Urokinase Upregulation.2004

Author(s)

Journal Title

Data Source

NISHIGUCHI Tomizo 西口富三

KOBAYASHI Takao 西口富三