AIZAWA Shin 相沢信

… Alternative Names

相澤信アイザワシン

相沢信アイザワシン

Less

Researcher Number	30202443
Other IDs
External Links
Affiliation (Current)	2022: 日本大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2001 – 2020: Nihon University School of Medicine, Department of Anatomy, Professor, 医学部, 教授 1999 – 2000: 日本大学, 医学部, 助教授 1996 – 1997: 日本大学, 医学部, 助教授 1993: 東京医科大学, 医学部, 助手 1990: 東京医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator General anatomy (including Histology/Embryology) / General anatomy (including Histology/Embryology) / Hematology / General anatomy (including histology/embryology) / Basic Section 48010:Anatomy-related Except Principal Investigator Medical pharmacy / Pathological medical chemistry / Pediatrics
Keywords	Principal Investigator 造血微小環境 / 造血幹細胞 / 骨髄ストローマ細胞 / ストローマ細胞 / 細胞・組織 / bone marrow stromal cell / hematopoietic stem cell / cyclic polylactate / 造血因子 / 細胞分化・組織形成 … More / 三次元培養 / 老化促進モデルマウス / サイトカイン / hematopoietic microenvironment / アポトーシス / 骨髄異形成症候群 / apoptosis / myelodysplastic syndrome / anaerobic glycolysis / TNFα / 細胞間相互作用 / 発生・分化 / Senescence-accelerated mice / 骨髄 / 三次元骨髄培養法 / 三次元骨髄培養 / CD34 / hematopoiesis / 環状重合乳酸 / 解糖系 / 細胞周期 / マクロファージ / 遺伝子導入 / ウイルスベクター / 骨髄長期培養 / アデノウイルス / 細胞分化 / 組織形成 / 骨髄移植 / 脾臓 / 高分子微粒子担体 / 間葉系幹細胞 / 人工骨髄 / 接着因子 / 長期骨髄細胞培養 / adherent molecule / artificial bone marrow / cytokine / long-term bone marrow culture / 造血組織 / 嫌気的解糖系 / vitamin K_2 / 多糖系酵素 / トランスポーター / 骨髄異形形成症候群 / transporter / cytarabine / M1マクロファージ / 老化促進マウス … More Except Principal Investigator 造血幹細胞 / トランスポーター / 溶血性貧血 / フレンド細胞 / 骨髄間質細胞 / 細胞間相互作用 / アデノウイルス / SV40 T抗原 / 造血微小環境 / サイトカイン / 細胞分化 / 血球 / 分化 / 増殖 / OCTN / アミノ酸 / アルギニン / CAT1 / 薬物動態・代謝学 / 輸送体 / 前立腺癌 / ホルモン / 去勢抵抗性 / 化学療法 / 前立腺がん / OATP / がん / 幹細胞 / 白血病 / アポトーシス / 解糖系 / 活性酸素種 / モデルマウス / 遺伝子治療 / トランスジェニックマウス / hemolytic anemia / apoptosis / glycolysis / reactive oxygen species / disease model animals / Friend cells / 臍帯血 / 生物学的特性 / In vivo増幅 / ヘマンジオブラスト / 血管内皮細胞 / 造血細胞 / 血管内皮培養 / 造血管細胞 / umbilical cord blood / hematopoietic stem cell / biological characteristic / hemangioblast / in vitro culture of endotherial cell / 無効造血 / 赤血球 / ピルビン酸キナーゼ / 赤血球酵素異常症 / 遺伝性疾患 / RNAi / アイソザイム / HEMOLYTIC ANEMIA / MUTATION / PYRUVATE KINASE / GLYCOLYSIS / ERYTHROCYTES / APOPTOSIS Less

Distribution and hematopoietic regulatory function of stromal cells in hematopoietic microenvironmentPrincipal Investigator
- Principal Investigator
  
  AIZAWA Shin
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48010:Anatomy-related
- Research Institution
  Nihon University
Distribution and hematopoietic regulatory function of stromal cells in hematopoietic microenvironmentPrincipal Investigator
- Principal Investigator
  
  AIZAWA shin
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General anatomy (including histology/embryology)
- Research Institution
  Nihon University
Regulation of hematopoiesis by bone marrow stromal cells in three-dimensional envirnmentPrincipal Investigator
- Principal Investigator
  
  AIZAWA Shin
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  Nihon University
New rational for chemotherapy targeting transporters expressed in cancer stem cells
- Principal Investigator
  
  NAKANISHI Takeo
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Kanazawa University
A study for the role of bone marrow stromal cells in hematopoietic regulationPrincipal Investigator
- Principal Investigator
  
  AIZAWA Shin
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  Nihon University
A study for the constitution and the hematopoietic regulatory mechanism of bone marrow microenvironment in vivoPrincipal Investigator
- Principal Investigator
  
  AIZAWA Shin
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  Nihon University
トランスポーター発現プロファイルに基づく細胞分化・増殖制御手法
- Principal Investigator
  
  TAMAI Ikumi
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  Tokyo University of Science
A study for the mechanism of hematopoietic regulation by bone marrow stromal cellsPrincipal Investigator
- Principal Investigator
  
  AIZAWA Shin
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  Nihon University
MOLECULAR MECHANISMS OF ACCELERATED ERYTHROID APOPTOSIS DUE TO A GLYCOLYTIC ENZYME DEFECT
- Principal Investigator
  
  KANNO Hitoshi
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  TOKYO WOMEN'S MEDICAL UNIVERSITY
A study for the mechanism of negative hematopoietic regulation by bone marrow microenvironment.Principal Investigator
- Principal Investigator
  
  AIZAWA Shin
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  Nihon University
Study for the mechanism of hematopoietic regulation by bone marrow microenvironmentPrincipal Investigator
- Principal Investigator
  
  AIZAWA Shin
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  Nihon University
Physiological significance of pyruvate kinase isozymes in erythrocyte.
- Principal Investigator
  
  KANNO Hitoshi
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  NIHON UNIVERSITY
Biological characteristics of cord blood stem cell and establishment of in vitro assay of human hematopoietic stem cells
- Principal Investigator
  
  MUGISHIMA Hideo
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Nihon University
Experimental model for the development of the artificial bone marrowPrincipal Investigator
- Principal Investigator
  
  AIZAWA Shin
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  Nihon University
ヒト造血系細胞へのウイルスベクターによる遺伝子導入法の開発-造血現象のin vitro再構築の検討-Principal Investigator
- Principal Investigator
  
  相沢信
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Tokyo Medical University
骨髄間質細胞による造血幹細胞の分化,増殖の統御機構ーウイルスベクタ-を用いた遺伝子導入法の造血系への応用ー
- Principal Investigator
  
  外山圭助
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Medical University

[Journal Article] Kinetics of leukemic cells in 3D culture with stromal cells and with arginine deprivation stress2020
- Author(s)
  Harada T., Tsuboi I., Utsunomiya M., Yasuda M., Aizawa S.
- Journal Title
  
  Journal of Bioscience and Bioengineering
  
  Volume: 130 Issue: 6 Pages: 650-658
- DOI
  10.1016/j.jbiosc.2020.07.018
- NAID
  40022441989
- ISSN
  1389-1723
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06846, KAKENHI-PROJECT-18K08568
[Journal Article] Dynamics of hematopoiesis is disrupted by impaired hematopoietic microenvironment in a mouse model of hemophagocytic lymphohistiocytosis2020
- Author(s)
  Tsuboi Isao、Harada Tomonori、Hirabayashi Yoko、Aizawa Shin
- Journal Title
  
  Annals of Hematology
  
  Volume: 99 Pages: 1515-1523
- DOI
  10.1007/s00277-020-04095-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07053, KAKENHI-PROJECT-18K06846
[Journal Article] Abemaciclib Induces Atypical Cell Death in Cancer Cells Characterized by Formation of Cytoplasmic Vacuoles Derived From Lysosomes2020
- Author(s)
  Hino Hirotsugu, Iriyama Noriyoshi, Kokuba Hiroko, Kazama Hiromi, Moriya Shota, Takano Naoharu, Hiramoto Masaki, Aizawa Shin, Miyazawa Keisuke
- Journal Title
  
  Cancer Sci.
  
  Volume: － Pages: 1-1
- DOI
  10.1111/cas.14419
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15031, KAKENHI-PROJECT-17K08771, KAKENHI-PROJECT-19K07107, KAKENHI-PROJECT-20K08970, KAKENHI-PROJECT-18K06846, KAKENHI-PROJECT-18K06901, KAKENHI-PROJECT-17K15031
[Journal Article] Senescence-accelerated mice (SAMP1/TA-1) treated repeatedly with lipopolysaccharide develop a condition that resembles hemophagocytic lymphohistiocytosis.2019
- Author(s)
  Tsuboi Isao、Harada Tomonori、Hirabayashi Yoko、Aizawa Shin
- Journal Title
  
  Haematologica
  
  Volume: 104 Pages: 1995-2005
- DOI
  10.3324/haematol.2018.209551
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07053, KAKENHI-PROJECT-18K06846
[Journal Article] Organic anion transporters, OAT1 and OAT3, are crucial biopterin transporters involved in bodily distribution of tetrahydrobiopterin and exclusion of its excess2017
- Author(s)
  Ohashi Akiko、Mamada Kaori、Harada Tomonori、Naito Masako、Takahashi Tomihisa、Aizawa Shin、Hasegawa Hiroyuki
- Journal Title
  
  Molecular and Cellular Biochemistry
  
  Volume: 435 Pages: 97-108
- DOI
  10.1007/s11010-017-3060-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08161, KAKENHI-PROJECT-16K20429
[Journal Article] In vitro chemosensitivity study of human leukemic cells in a three-dimensional bone marrow culture system2016
- Author(s)
  Fukino N., Harada T., Tsuboi I., Fukui S., Yasuda M., Aizawa S.
- Journal Title
  
  Journal of Hematology and Therapeutics
  
  Volume: 1 Pages: 7-15
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K08161
[Journal Article] Differential regulation of lympho-myelopoiesis by stromal cells in the early and late phases in BALB/c mice repeatedly exposed to lipopolysaccharide2016
- Author(s)
  Tsuboi I., Harada T., Hirabayashi Y., Kanno J., Aizawa S.
- Journal Title
  
  Biol Pharm Bull
  
  Volume: 39 Pages: 1939-1947
- NAID
  130005171505
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K08161
[Journal Article] Age-related functional changes in hematopoietic microenvironment2016
- Author(s)
  Tsuboi I., Harada T., Aizawa S.
- Journal Title
  
  JPFSM
  
  Volume: 5 Issue: 2 Pages: 167-175
- DOI
  10.7600/jpfsm.5.167
- NAID
  130005151607
- ISSN
  2186-8123, 2186-8131
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08161
[Journal Article] Decreased “ineffective erythropoiesis” preserves polycythemia in mice under long-term hypoxia2015
- Author(s)
  Harada T., Tsuboi I., Hirabayashi Y., Kosaku K., Naito M., Hara H., Inoue T., Aizawa S.
- Journal Title
  
  Clin Exp Med
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24590262
[Journal Article] Kinetics of hematopoietic stem cells and supportive activities of stromal cells in a three-dimensional bone marrow culture system2015
- Author(s)
  Harada T., Hirabayashi Y., Hatta Y., Tsuboi I., Glomn WR., Yasuda M., Aizawa S.
- Journal Title
  
  Growth Factors
  
  Volume: 33 Pages: 347-355
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K08161
[Journal Article] Decrease ineffective erythropoiesis preserves polycythemia in mice long-term hypoxia2015
- Author(s)
  Harada T, Tsuboi I, Hirabayashi Y, Okamura T, Kosaku K, Naito M, Hara H, Inoue T. Aizawa S.
- Journal Title
  
  Clinical and Experimental Medicine
  
  Volume: 15 Pages: 179-188
- DOI
  10.1007/s10238-014-0286-5
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K08161
[Journal Article] Lipopolysaccharide reciprocally alters the positive and negative balance regulated by stromal cells between myelopoiesis and B lymphopoiesis in C57BL/6 mice2014
- Author(s)
  Taki M., Tsuboi I., Harada T., Naito M., Hara H., Inoue T., Aizawa S.
- Journal Title
  
  Biol Pharm Bull
  
  Volume: 37 Pages: 1872-81
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24590262
[Journal Article] Hematopoiesis in mice in response to chronic hypoxia2013
- Author(s)
  Okamura H., Hirabayashi Y., Harada T., Kosaku K., Tsuboi I., Aizawa S.
- Journal Title
  
  J Nihon Univ Med Ass
  
  Volume: 72 Pages: 266-273
- NAID
  130004781722
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590262
[Journal Article] Aquaporin 9, a promising predictor for the cytocidal effects of arsenic trioxide in acute promyelocytic leukemia cell lines and primary blasts2013
- Author(s)
  Iriyama N., Yuan B., Yoshino Y., Hatta Y., Horikoshi A., Aizawa S., Takeuchi J., Toyoda H.
- Journal Title
  
  Oncol Rep
  
  Volume: 29 Pages: 2362-2368
- DOI
  10.3892/or.2013.2388
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590262
[Journal Article] Neopterin, inflammation-associated product, prolongs erythropoiesis suppression in aged SAMP1 mice due to senescent stromal-cell impairment2012
- Author(s)
  Aisaki K., Tsuboi I., Harada T., Oshima H., Yamashita A., Hirabayashi Y., Kanno J., Inoue T., Aizawa S
- Journal Title
  
  Exp Biol Med
  
  Volume: 237 Pages: 279-286
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590223
[Journal Article] Neopterin, inflammation-associated product, prolongs erythropoiesis suppression in aged SAMP1 mice due to senescent stromal-cell impairment2012
- Author(s)
  Aisaki K., Tsuboi I., Harada T., Oshima H., Yamashita A., Hirabayashi Y., Kanno J., Inoue T., Aizawa S.
- Journal Title
  
  Exp Biol Med
  
  Volume: (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590223
[Journal Article] Age-related decline of mast cell regeneration in senescence-accelerated mice (SAMP1) after chemical myeloablation due to senescent stromal cell impairment.2012
- Author(s)
  Tsuboi I., Harada T., Hirabayashi Y., Kanno J., Inoue T., Aizawa S.
- Journal Title
  
  Exp Biol Med (Maywood)
  
  Volume: 237 Pages: 1289-1297
- DOI
  10.1258/ebm.2012.012158
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590262, KAKENHI-PROJECT-24590467
[Journal Article] Neopterin, inflammation-associated product, prolongs erythropoiesis suppression in aged SAMP1 mice due to senescent stromal-cell impairment.2012
- Author(s)
  Aisaki, K., et al
- Journal Title
  
  Experimental biology and medicine (Maywood, N.J.)
  
  Volume: 237 Pages: 279-286
- DOI
  10.1258/ebm.2011.011303
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590388, KAKENHI-PROJECT-21510074, KAKENHI-PROJECT-24590262, KAKENHI-PROJECT-24590467, KAKENHI-PROJECT-24790202
[Journal Article] Azacitidine induces demethylation of p16INK4a and inhibits growth in adult T-cell leukemia/lymphoma2011
- Author(s)
  Uenogawa K., Hatta Y., Arima N., Hayakawa S., Sawada U., Aizawa S., Yamamoto T., Takeuchi J
- Journal Title
  
  Int J Mol Med
  
  Volume: 28 Pages: 835-839
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590223
[Journal Article] Adhesive cell cultivation on polymer particle having grafted epoxy polymer chain2011
- Author(s)
  Yasuda M., Kunieda H., Ono K., Iwasaki T., Hiramoto M., Glomm WR., Hirabayashi Y., Aizawa S.
- Journal Title
  
  Tissue Cell
  
  Volume: 43 Pages: 115-124
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590223
[Journal Article] Novel three-dimensional long-term bone-marrow culture system using polymer particles with grafted epoxy-polymer-chains supports the proliferation and differentiation of hematopoietic stem-cells2011
- Author(s)
  Hirabayashi Y., Hatta Y., Takeuchi J., Tsuboi I., Harada T., Ono K., Glomm WR., Yasuda M., Aizawa S
- Journal Title
  
  Exp Biol Med
  
  Volume: 236 Pages: 1342-1350
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590223
[Journal Article] Adhensive cell cultivation on polymer particle having grafted epoxy polymer chain2011
- Author(s)
  Yasuda M., Kunieda H., Ono K., Iwasaki T., Hiramoto M., Glomm WR., Hirabayashi Y., Aizawa S
- Journal Title
  
  Tissue Cell
  
  Volume: 43 Pages: 115-124
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590223
[Journal Article] Membrane transport of sepiapterin and dihydrobiopterin by equiliarative nucleoside transporters : A plausible gateway for the salvage pathway of tetrahydrobiopterin biosynthesis2011
- Author(s)
  Ohashi A., Sugawara Y., Mamada K., Harada Y., Sumi T., Anzai N., Aizawa S., Hasegawa H
- Journal Title
  
  Mol Genet Metab
  
  Volume: 102 Pages: 18-28
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590223
[Journal Article] Mast cell development and biostresses : different stromal responses in bone marrow and spleen after treatment of myeloablator, 5-fluorouracil, and inflammatory stressor, lipopolysaccharide2011
- Author(s)
  Hokari T., Tsuboi I., Harada T., Oshima H., Hirabayashi Y., Kanno J., Inoue T., Aizawa S
- Journal Title
  
  Biol Pharma Bull
  
  Volume: 34 Pages: 1533-1541
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590223
[Journal Article] Inflammatory biomarker, neopterin, predominantly enhances myelopoiesis, which suppresses erythropoiesis via activated stromal cells2010
- Author(s)
  Tsuboi I., Harada T., Hirabayashi Y., Kanno J., Inoue T., Aizawa S
- Journal Title
  
  Immunobiology
  
  Volume: 215 Pages: 348-355
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590223
[Journal Article] Effect of neopterin on splenic erythropoiesis in mice2010
- Author(s)
  Tsuboi I., Harada T., Oshima H., Aizawa S
- Journal Title
  
  Pteridines
  
  Volume: 21 Pages: 7-10
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590223
[Journal Article] Effect of neopterin on the hematopoietic system2009
- Author(s)
  Tsuboi I, Aizawa S
- Journal Title
  
  Pteridines 20
  
  Pages: 129-134
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590223
[Journal Article] In vitro effect of neopterin on erythropoiesis in mice2009
- Author(s)
  Tsuboi I., Hokari T., Harada T., Yuda., Aizawa S
- Journal Title
  
  Pteridines
  
  Volume: 20 Pages: 115-118
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590223
[Journal Article] Inflammatory biomarker, neopterin, predominantly enhances myelopoiesis, which suppresses erythropoiesis via activated stromal cells2009
- Author(s)
  Tsuboi I, Harada T, Hirabayashi Y, Kanno J, Inoue T, Aizawa S
- Journal Title
  
  Immunobiology 8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590223
[Journal Article] In vitro effect of neopterin on erythropoiesis in mice2009
- Author(s)
  Tsuboi I, Hokari T, Harada T, Yuda M, Aizawa S
- Journal Title
  
  Pteridines 20
  
  Pages: 115-118
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590223
[Journal Article] Stromal cells in bone marrow play important roles in pro-inflammatory cytokine secretion causing fever following bortezomib administration in patients with multiple myeloma2008
- Author(s)
  Maruyama D., Watanabe T., Heike Y., Nagase K., Takahashi N., Yamasaki S., Waki F., Kobayashi Y., Aizawa S., Tobinai K.
- Journal Title
  
  Int J Hematol 88
  
  Pages: 396-402
- NAID
  10023970731
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590196
[Journal Article] Role of hematopoietic microenvironment in prolonged impairment of Bcell regeneration in age-related stromal cell-impaired(SCI)SAMP1 mouse: Effects of a single dose of 5-fluorouracil2008
- Author(s)
  Tsuboi I., Hirabayashi Y., Harada T., Koshinaga M., Kawamata T., Kanno J., Inoue T., Aizawa S.
- Journal Title
  
  J Appl Toxicol (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590196
[Journal Article] Stromal cells in bone marrow play important roles in pro-inflammatory cytokine secretion causing fever following bortezomib administration in patients with multiple myeloma2008
- Author(s)
  Maruyama D, Watanabe T, Heike Y, Nagase K, Takahashi N, Yamasaki S, Waki F, Kobayashi Y, Aizawa S, Tobinai K
- Journal Title
  
  Internatinal Journal of Hematology 88
  
  Pages: 396-402
- NAID
  10023970731
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590196
[Journal Article] Predominant regeneration of B cell linage, instead of myeloid linage of the bone marrow after 1 Gy-whole body irradiation in mice : Role of differential cytokines expression between B cell stimulation by IL-10, Flt3-ligand and IL-7, and myeloid suppression by GM-CSF and SCF2008
- Author(s)
  Tsuboi I, Hirabayashi Y, Harada, T, Hiramoto M, Kanno J, Inoue T, Aizawa S
- Journal Title
  
  Radiation Research 170
  
  Pages: 15-22
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590196
[Journal Article] Role of hematopoietic microenvironment in prolonged impairment of B cell regeneration in age-related stroma-cell impaired (SCI) SAMPl mouse : effect of a single dose of 5-fluorouracil2008
- Author(s)
  Tsuboi I, Hirabayashi Y, Harada T, Koshinaga M, Kawamata T, Kanno J, Inoue T, Aizawa S
- Journal Title
  
  Journal of Applied Toxicology 28
  
  Pages: 797-805
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590196
[Journal Article] Role of hematopoietic microenvironment in prolonged impairment of Bcell regeneration in age-related stromal-cell-impaired (SCI) SAMP1 mouse : Effects of a single dose of 5-fluorouracil2008
- Author(s)
  Tsuboi I., Hirabayashi Y., Harada T., Koshinaga M., Kawamata T., Kanno J., Inoue T., Aizawa S.
- Journal Title
  
  J Appl Toxicol 28
  
  Pages: 797-805
- Data Source
  KAKENHI-PROJECT-18590196
[Journal Article] Inflammatory biomarker, neopterin, suppresses B-lymphopoiesis for possible facilitation of granulocyte responses2007
- Author(s)
  Minami A., Tsuboi I., Harada T., Fukumoto T., Hiramoto M., Koshinaga M., Hirabayashi Y., Kanno J., Inoue T., Aizawa S.
- Journal Title
  
  which is severely altered in age-related stromal-cell-impaired mice, SCI/SAM. Exp Bio Med 232
  
  Pages: 134-145
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590196
[Journal Article] Decreased Proliferation and Erythroid Differentiation of K562 Cells by siRNA-induced Depression of OCTN1 (SLC22A4) Transporter Gene.2007
- Author(s)
  Nakamura T, Sugiura S, Kobayashi D, Yoshida K, Yabuuchi Y, Aizawa S, Maeda T, Tamai I
- Journal Title
  
  PHARMACEUTICAL RESEARCH (in press)
- Data Source
  KAKENHI-PROJECT-17659049
[Journal Article] Glycolytic inhibition by mutation of pyruvate kinase gene increases oxidative stress and causes apoptosis of a pyruvate kinase defficient cell lines2007
- Author(s)
  Aisaki K., Aizawa S., Fujii H., Kanno J., Kanno H.
- Journal Title
  
  Exp Hematol 35
  
  Pages: 1190-1200
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590196
[Journal Article] In vitro effect of neopterin on splenic mast cell development in senescence accelerated mice (SAM)2007
- Author(s)
  Harada T., Tsuboi I., Yuda M., Wakasugi K., Aizawa S.
- Journal Title
  
  Pteridines 18
  
  Pages: 101-105
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590196
[Journal Article] Inflammatory biomarker, neopterin, suppresses B-lymphopoiesis for possible facilitation of granulocyte responses, which is severely altered in age-related stromal-cell-impaired mice, SCI/SAM2007
- Author(s)
  Minami A., Tsuboi I., Harada T., Fukumoto T., Hiramoto M., Koshinaga M., Hirabayashi Y., Kanno J., Inoue T., Aizawa S.
- Journal Title
  
  Exp Bio Med 232
  
  Pages: 134-145
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590196
[Journal Article] In vitro effect of neopterin on splenic mast cell development in senescence accelerated mice(SAM)2007
- Author(s)
  Harada T., Tsuboi I., Yuda M., Wakasugi K., Aizawa S.
- Journal Title
  
  Pteridines 18
  
  Pages: 101-105
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590196
[Journal Article] Transgenic rescue of hemolytic anemia due to red blood cell pyruvate deficiency2007
- Author(s)
  Kanno H., Utsugisawa T., Aizawa S., Koizumi T., Aisaki K., Hamada T., Ogura H., Fujii H.
- Journal Title
  
  Haematologica 92
  
  Pages: 731-737
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590196
[Journal Article] Decreased proliferation and erythroid differentiation of K562 cells by depression of OCTN1(SLC22A4)transporter gene by sRNA2007
- Author(s)
  Nakamura T., Maeda T., Kobayashi D., Sugiura S., Aizawa S., Yabuuchi H., Tamai I.
- Journal Title
  
  Pharm Res 24
  
  Pages: 1628-1635
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590196
[Journal Article] Decreased proliferation and erythroid differentiation of K562 cells by depression of OCTN1(SLC22A4) transporter gene by sRNA2007
- Author(s)
  Nakamura T., Maeda T., Kobayashi D., Sugiura S., Aizawa S., Yabuuchi H., Tamai I.
- Journal Title
  
  Pharm Res 24
  
  Pages: 1628-1635
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590196
[Journal Article] Predominant regulation of B-cell lineage, instead of myeloid lineage, of the bone marrow after 1 Gy whole-body irradiation in mice : Role of differential cytokine expression between B-cell stimulation by IL102006
- Author(s)
  Tsuboi I., Hirabayashi Y., Harada T., Hiramoto M., Kanno J., Inoue T., Aizawa S.
- Journal Title
  
  Flt3 ligand and IL7 and myeloid supression by GM-CSF and SCF. Rad Res 170
  
  Pages: 15-22
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590196
[Journal Article] Inflammatory biomarker, neopterin enlarges splenic mast-cell-progenitor pool : prominent impairment of responses in age-related stromal cell-impairment mouse SCI/SAM2006
- Author(s)
  Fukumoto T., Tsuboi I., Harada T., Hiramoto M., Minami A., Koshinaga M., Hirabayashi Y., Kanno J., Inoue T., Aizawa S.
- Journal Title
  
  Int Immunopharmacol 6
  
  Pages: 1847-1858
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590196
[Journal Article] L-arginine import via cationic amino acid transporter CAT1 is essential for both differentiation and proliferation of erythrocytes.2006
- Author(s)
  Shima Y, Maeda T, Aizawa S, Tsuboi I, Kobayashi D, Kato R, Tamai I.
- Journal Title
  
  BLOOD 107
  
  Pages: 1352-1356
- Data Source
  KAKENHI-PROJECT-17659049
[Journal Article] Inflammatory biomarker, neopterin enlarges splenic mast-cell-progenitor pool : prominent impairment of responses in age-related stromal cell-impairment mouse SCI/SAM2006
- Author(s)
  Fukumoto T., Tsuboi I., Harada T., Aizawa S.et al.
- Journal Title
  
  Int Immunopharmacol 6
  
  Pages: 1847-1858
- Data Source
  KAKENHI-PROJECT-18590196
[Journal Article] Role of polyamine derived from arginine in differentiation and proliferation of human blood cells.2006
- Author(s)
  Maeda T, Wakasawa T, Shima Y, Tsuboi I, Aizawa S, Tamai I.
- Journal Title
  
  BIOLOGICAL & PHARMACEUTICAL BULLETIN 29
  
  Pages: 231-239
- NAID
  110005663951
- Data Source
  KAKENHI-PROJECT-17659049
[Journal Article] Inflammatory biomarker, neopterin, suppresses B-lymphopoiesis for possible facilitation of granulocyte responses, which is severely altered in age-related stromal-cell-impaired mice, SCI/SAM2006
- Author(s)
  Minami A., Tsuboi I., Harada T., Aizawa S.et al.
- Journal Title
  
  Exp Bio Med 232
  
  Pages: 134-145
- Data Source
  KAKENHI-PROJECT-18590196
[Journal Article] Effects of neopterin on the hematopoietic microenvironment of senescence-accelerated mice (SAM).2006
- Author(s)
  Kanbe E., Hatta Y., Tsuboi I., Harada T., Koshinaga M., Inoue T., Aizawa S.
- Journal Title
  
  Biol Pharma Bull 29
  
  Pages: 43-48
- NAID
  110005602080
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590196
[Journal Article] Senescent B-lymphopoiesis is balanced in suppressive homeostasis : Decrease in interleukin-7 and transforming growth factor-β levels in stromal cells of senescence-accelerated mice.2004
- Author(s)
  Tsuboi I., Morimoto K., Hirabayashi Y., Guang-Xun Li, Aizawa S., Mori JK, Kanno J., Inoue T.
- Journal Title
  
  Exp Bio Med 229
  
  Pages: 494-502
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590176
[Journal Article] 老化促進モデルマウスを用いた老化に伴う造血微小環境の機能変化の検討2004
- Author(s)
  川上裕, 壷井功, 相沢信
- Journal Title
  
  日大医誌 63
  
  Pages: 418-424
- NAID
  10014080210
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590176
[Journal Article] Altered membrane permeability to fluorescein diacetate by adenosine triphosphate(ATP) in L1210 leukemic cells.2004
- Author(s)
  Hatta Y., Itoh T., Baba M., Aizawa S., Sawada U., Horie T.
- Journal Title
  
  Nihon Univ J Med 46
  
  Pages: 61-68
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590176
[Journal Article] Identification of differentiation-inducing activity produced by human bone marrow stromal cell line LP101.2004
- Author(s)
  Hiramoto M., Kawakami Y., Nabeshima R., Shima D., Handa H., Aizawa S.
- Journal Title
  
  Int J Mol Med 14
  
  Pages: 867-872
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590176
[Journal Article] Expression of organic transporter OCTN1 in hematopoietic cells during erythroid differentiation.2004
- Author(s)
  Kobayashi D., Aizawa S., Maeda T., Tsuboi I., Yabuuchi H., Nezu J., Tsuji A., Tamai I.
- Journal Title
  
  Exp Hematol 32
  
  Pages: 1156-1162
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590176
[Journal Article] Vitamin K2 improves the hematopoietic supportive functions of bone marrow stromal cells in vitro : A possible mechanism of improvement of cytopenia for refractory anemia in response to vitamin K2 therapy.2004
- Author(s)
  Miyazawa K., Aizawa S.
- Journal Title
  
  Stem Cells Dev 13
  
  Pages: 449-451
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590176
[Journal Article] Ineffective erythropoiesis in the spleen of a patient with pyruvate kinase deficiency2003
- Author(s)
  Aizawa S. et al.
- Journal Title
  
  American Journal of Hematology 74
  
  Pages: 68-72
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590176
[Journal Article] Requirement of soluble factor(s) produced by bone marrow stromal cells on the growth of novel established human myeloma cell line.2003
- Author(s)
  Aikawa S., Hatta Y., Tanaka M., Kaneita Y., Yasukawa K., Sawada U., Horie T., Tsuboi I., Aizawa S.
- Journal Title
  
  Int J Oncol 22
  
  Pages: 631-637
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590176
[Journal Article] Effects of neopterin on the proliferation and differentiation of hematopoietic progenitors derived from human um bilical cord blood.2003
- Author(s)
  Kawakami Y., Aizawa S., Hiramoto M., Tsuboi I., Wakasugi K.
- Journal Title
  
  Pteridines 14
  
  Pages: 129-132
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590176
[Journal Article] Ineffective erythropoiesis in the spleen of a patient with pyruvate kinase deficiency.2003
- Author(s)
  Aizawa S., Kohdera U., Hiramoto M., Kawakami Y., Aisaki K., Kobayashi Y., Miwa S., Fujii H., Kanno H.
- Journal Title
  
  Am J Hematol 74
  
  Pages: 68-72
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590176
[Journal Article] Increased number of hematopoietic stem cells in adherent layer of bone marrow cell culture with stroma by treatment with granulocyte colony-stimulating factor.2003
- Author(s)
  Tsuboi I., Hiramoto M., Hatta Y., Sawada U, Horie T., Aizawa S.
- Journal Title
  
  日大医誌 62
  
  Pages: 154-158
- NAID
  10010727405
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590176
[Patent] 造血幹細胞の培養方法2009
- Inventor(s)
  相沢信、原田智紀、安田昌弘
- Industrial Property Rights Holder
  公立大学法人大阪府立大学、学校法人日本大学
- Filing Date
  2009-03-25
- Data Source
  KAKENHI-PROJECT-18590196
[Presentation] Hematopoietic tissue is one of the organs that suffer lifethreatening damage in HLH2021
- Author(s)
  原田智紀、壷井功、日野浩嗣、内藤美智子、原弘之、相澤信
- Organizer
  第126回日本解剖学会総会・全国学術集会 / 第98回日本生理学会大会　合同大会
- Data Source
  KAKENHI-PROJECT-18K06846
[Presentation] LPS投与による血球貪食性リンパ組織球症様病態像モデルマウス2020
- Author(s)
  原田智紀、壷井功、日野浩嗣、内藤美智子、原弘之、相澤信
- Organizer
  第125回日本解剖学会総会・全国学術集会
- Data Source
  KAKENHI-PROJECT-18K06846
[Presentation] LPS投与頻回により老化促進モデルマウス（SAMP1/TA-1）は血球貪食性リンパ組織球症様病態像を呈する2019
- Author(s)
  原田智紀、壷井功、相澤信
- Organizer
  第81回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-18K06846
[Presentation] 造血制御システムの破綻と老化2019
- Author(s)
  原田智紀、相澤信
- Organizer
  第124回日本解剖学会総会全国学術集会
- Data Source
  KAKENHI-PROJECT-18K06846
[Presentation] Chemosennsitivity study in a model of simulated bone marrow: three-dimensional culture system2018
- Author(s)
  Harada T, Tsuboi I., Aizawa S
- Organizer
  第80回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-18K06846
[Presentation] 三次元培養法における白血病細胞の動態2018
- Author(s)
  原田智紀、壷井功、内藤美智子、古作和寛、原弘之、相澤信
- Organizer
  第123回日本解剖学会総会・全国学術集会
- Data Source
  KAKENHI-PROJECT-15K08161
[Presentation] LPS頻回投与における慢性炎症下の加齢様B細胞造血能低下について2017
- Author(s)
  原田智紀、壷井功、内藤美智子、古作和寛、原弘之、相澤信
- Organizer
  第122回日本解剖学会総会・全国学術集会
- Place of Presentation
  長崎大学坂本キャンパス（長崎県　長崎市）
- Year and Date
  2017-03-28
- Data Source
  KAKENHI-PROJECT-15K08161
[Presentation] Mocrolides enhance bortezomic-induced cytotoxicity in myeloma cells co-cultured with stroma layer2016
- Author(s)
  Moriya S., Kazama H., Hiramoto M., Aizawa S., Sunazuka T., Handa H., Miyazawa K.
- Organizer
  第78回日本血液学会学術集会
- Place of Presentation
  パシフィコ横浜（神奈川県　横浜市）
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-15K08161
[Presentation] LPS頻回投与による造血系の加齢様変化におけるストローマ細胞機能低下についての検討2016
- Author(s)
  壷井　功、原田智紀、平林容子、菅野　純、相澤　信
- Organizer
  第39回日本基礎老化学会大会
- Place of Presentation
  伊勢原市民文化会館（神奈川県　伊勢原市）
- Year and Date
  2016-05-27
- Data Source
  KAKENHI-PROJECT-15K08161
[Presentation] 三次元骨髄培養モデルにおける造血支持特性2016
- Author(s)
  原田智紀、壷井　功、内藤美智子、古作和寛、原　弘之、相澤　信
- Organizer
  第121回日本解剖学会　総会・全国学術集会
- Place of Presentation
  ビックパレットふくしま　(福島県　郡山市）
- Year and Date
  2016-03-28
- Data Source
  KAKENHI-PROJECT-15K08161
[Presentation] Role of connexin 32 in hematopoiesis: maintenance of cell capability to reconstitute bone marrow2015
- Author(s)
  Hirabayashi Y, Tsuboi I, Yoon BI,Kanno J, Aizawa S
- Organizer
  The 77th Annual meeting of the Japanese society of hematology
- Place of Presentation
  ホテル金沢他　(石川県　金沢市）
- Year and Date
  2015-10-16
- Data Source
  KAKENHI-PROJECT-15K08161
[Presentation] 老化促進モデルマウスを用いた加齢に伴う肥満細胞造血の変動についての検討2015
- Author(s)
  壷井　功、原田智紀、内藤美智子、原　弘之、平林容子、菅野　純、相澤　信
- Organizer
  第38回日本基礎老化学会
- Place of Presentation
  パシフィコ横浜　(神奈川県　横浜市）
- Year and Date
  2015-06-13
- Data Source
  KAKENHI-PROJECT-15K08161
[Presentation] Mechanism for sustained polycythemia in mice under hypoxic condition2015
- Author(s)
  Harada T, Tsuboi I, Hirabayashi Y, Hirabayashi Y, Kanno J, Aizawa S
- Organizer
  The 77th Annual meeting of the Japanese society of hematology
- Place of Presentation
  ホテル金沢他　(石川県　金沢市）
- Year and Date
  2015-10-16
- Data Source
  KAKENHI-PROJECT-15K08161
[Presentation] 低酸素環境下飼育マウスの造血制御機構について2014
- Author(s)
  原田智紀、壷井　功、内藤美智子、古作和寛、原　弘之、井上　達、相澤　信
- Organizer
  第119回日本解剖学会総会・全国学術集会　下野　2014.3
- Place of Presentation
  下野（自治医科大学）
- Data Source
  KAKENHI-PROJECT-24590262
[Presentation] SAMP1:加齢に伴う間質細胞の機能低下により5-FU投与後の肥満細胞造血反応は低下する2013
- Author(s)
  壷井　功、原田智紀、平林容子、菅野　純、井上　達、相沢　信
- Organizer
  第28回老化促進モデルマウス研究協議会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-24590262
[Presentation] 加齢マウスにおけるストローマ細胞機能低下が肥満細胞造血に与える影響について2013
- Author(s)
  原田智紀、壷井功、古作和寛、原弘之、井上達、相沢信
- Organizer
  第118回日本解剖学会総会・全国学術集会
- Place of Presentation
  高松
- Data Source
  KAKENHI-PROJECT-24590262
[Presentation] Age-related stromal cell impairment reduces mast cell regeneration in mice after myeloablation2013
- Author(s)
  Harada T, Tsuboi I, Hirabayashi Y,Kanno J, Inoue T, Aizawa S.
- Organizer
  The75th annual meeting of the Japanese society of hematology
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-24590262
[Presentation] Regulation of mast cell development by hematopoietic microenvironment in mice2012
- Author(s)
  Harada T., Hokari T., Tsuboi I., Hirabayashi Y., Kanno J., Inoue T., Aizawa S.
- Organizer
  第74回日本血液学会学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-24590262
[Presentation] 高分子微粒子担体とMS-5細胞を用いた三次元骨髄培養モデルにおける造血支持能2012
- Author(s)
  原田智紀、壷井功、大島秀規、原弘之、井上達、相澤信
- Organizer
  第117回日本解剖学会総会
- Place of Presentation
  甲府
- Year and Date
  2012-03-26
- Data Source
  KAKENHI-PROJECT-21590223
[Presentation] 造血微小環境による肥満細胞造血の制御機構2011
- Author(s)
  原田智紀、壷井功、大島秀規、原弘之、井上達、相澤信
- Organizer
  第116回日本解剖学会総会
- Place of Presentation
  横浜
- Year and Date
  2011-03-29
- Data Source
  KAKENHI-PROJECT-21590223
[Presentation] 炎症性貧血の加齢に伴う重症化の機序についての検討2011
- Author(s)
  壷井功、原田智紀、平林容子、菅野純、井上達、相澤信
- Organizer
  第26回老化促進モデルマウス(SAM)研究協議会
- Place of Presentation
  岐阜
- Year and Date
  2011-07-08
- Data Source
  KAKENHI-PROJECT-21590223
[Presentation] Hematopoietic response subjected to long-term hypoxic condition in mice2011
- Author(s)
  Harada T., Tsuboi I., Hirabayashi Y., Oshima H., Hara H., Inoue T., Aizawa S
- Organizer
  International Hypoxia Symposium
- Place of Presentation
  Lake Louise, Albert, Canada
- Year and Date
  2011-02-15
- Data Source
  KAKENHI-PROJECT-21590223
[Presentation] 老化促進モデルマウスを用いた、炎症性貧血の加齢に伴う重症化の機序についての検討2011
- Author(s)
  相崎一雄、原田智紀、大島秀規、壷井功、相澤信
- Organizer
  第506回日大医学会例会
- Place of Presentation
  東京
- Year and Date
  2011-09-10
- Data Source
  KAKENHI-PROJECT-21590223
[Presentation] Age-related changes in erythropoietic response to neopterin in senescence accelerated mice2011
- Author(s)
  Tsuboi I., Harada T., Hirabayashi Y., Kanno J., Inoue T., Aizawa S
- Organizer
  第73回日本血液学会学術集会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-14
- Data Source
  KAKENHI-PROJECT-21590223
[Presentation] Effect of neopterin on erythropoiesis in mice2010
- Author(s)
  Hirabayashi Y., Tsuboi I., Harada T., Hirabayashi Y., Kanno J., Inoue T., Hatta Y., Takeuchi J., Aizawa S
- Organizer
  第721回日本血液学会学術集会
- Place of Presentation
  横浜
- Year and Date
  2010-09-25
- Data Source
  KAKENHI-PROJECT-21590223
[Presentation] SAMP1:加齢に伴う造血間質細胞の機能低下により炎症時の肥満細胞造血反応は低下する2010
- Author(s)
  壷井功、原田智紀、平林容子、菅野純、井上達、相澤信
- Organizer
  第25回老化促進モデルマウス(SAM)研究協議会
- Place of Presentation
  金沢
- Year and Date
  2010-07-09
- Data Source
  KAKENHI-PROJECT-21590223
[Presentation] SAMP1 :加齢に伴う造血間質細胞の機能低下により炎症時の肥満細胞造血反応は低下する2010
- Author(s)
  壷井功、原田智紀、平林容子、菅野純、井上達、相澤信
- Organizer
  第25回老化促進モデルマウス(SAM)研究協議会
- Place of Presentation
  金沢
- Year and Date
  2010-07-09
- Data Source
  KAKENHI-PROJECT-21590223
[Presentation] マウス骨髄の赤血球造血に対するネオプテリンの効果2010
- Author(s)
  原田智紀、壷井功、大橋晶子、大島秀規、原弘之、相澤信
- Organizer
  第115回日本解剖学会総会
- Place of Presentation
  盛岡
- Year and Date
  2010-03-28
- Data Source
  KAKENHI-PROJECT-21590223
[Presentation] 放射線照射径の造血微小環境はサイトカインを介してB細胞造血を促進と顆粒球造血を抑制する2009
- Author(s)
  壷井功, 原田智紀, 平林容子, 菅野純, 井上達, 相澤信
- Organizer
  第71回日本血液学会学術集会
- Place of Presentation
  京都
- Year and Date
  2009-10-25
- Data Source
  KAKENHI-PROJECT-21590223
[Presentation] 放射線照射後の造血微小環境はサイトカインを介してB細胞造血を促進と顆粒球造血を抑制する2009
- Author(s)
  壷井功、原田智紀、平林容子、菅野純、井上達、相澤信
- Organizer
  第71回日本血液学会学術集会
- Place of Presentation
  京都
- Year and Date
  2009-10-25
- Data Source
  KAKENHI-PROJECT-21590223
[Presentation] Myeloablation後のB細胞造血の回復は加齢による造血微小環境の機能低下により遅延する2009
- Author(s)
  壷井功、原田智紀、平林容子、菅野純、井上達、相澤信
- Organizer
  第32回基礎老化学会
- Place of Presentation
  横浜
- Year and Date
  2009-06-19
- Data Source
  KAKENHI-PROJECT-21590223
[Presentation] Myeloablation 後のB細胞造血の回復は加齢による造血微小環境の機能低下により遅延する2009
- Author(s)
  壷井功, 原田智紀, 平林容子, 菅野純, 井上達, 相澤信
- Organizer
  第32回基礎老化学会
- Place of Presentation
  横浜
- Year and Date
  2009-06-19
- Data Source
  KAKENHI-PROJECT-21590223
[Presentation] 放射線照射後のB細胞造血の促進と顆粒球造血の抑制は造血微小環境により制御される2009
- Author(s)
  壷井功、原田智紀、平林容子、菅野純、井上達、相澤信
- Organizer
  第24回老化促進モデルマウス(SAM)研究協議会
- Place of Presentation
  松本
- Year and Date
  2009-07-10
- Data Source
  KAKENHI-PROJECT-21590223
[Presentation] 放射線照射後の造血微小環境はサイトカイン産生を介してB細胞造血の回復を促進する2009
- Author(s)
  原田智紀、壷井功、大島秀規、相澤信
- Organizer
  第114回日本解剖学会総会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-18590196
[Presentation] 加齢に伴う造血微小環境の機能低下は抗癌剤後のB細胞造血を遅延させる2008
- Author(s)
  壷井功、平林容子、原田智紀、児玉幸夫、菅野純、井上達、相澤信
- Organizer
  第35回日本トキシコロジー学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-18590196
[Presentation] 赤血球造血に対するネオプテリンの効果日本プテリジンカンファレンス、サイトカイン・ネオプテリン研究会2008
- Author(s)
  原田智紀、壷井功、大島秀規、越永守道、若杉和倫、相澤信
- Organizer
  第4回連合研究発表会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-18590196
[Presentation] SAMP1加齢に伴う造血微小環境の機能低下は5-fluorouracil投与後のB細胞産生を遅延さす2008
- Author(s)
  壷井功、原田智紀、平林容子、菅野純、井上達、相澤信
- Organizer
  第23回老化促進モデルマウス(SAM)研究協議会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-18590196
[Presentation] 加齢に伴う造血微小環境の機能低下は抗癌剤投与後のB細胞産生を遅延さす2008
- Author(s)
  原田智紀、壷井功、大島秀規、越永守道、相澤信
- Organizer
  第113回日本解剖学会総会
- Place of Presentation
  大分
- Data Source
  KAKENHI-PROJECT-18590196
[Presentation] 加齢に伴う造血微小環境の機能低下は5-fluorouracil投与後のB細胞産生を遅延さす2008
- Author(s)
  壷井功、原田智紀、平林容子、菅野純、井上達、相澤信
- Organizer
  第70回日本血液学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-18590196
[Presentation] 赤血球造血に対するネオプテリンの効果2008
- Author(s)
  原田智紀, 壷井功, 大島秀規越永守道, 若杉和倫, 相沢信
- Organizer
  日本プテリジンカンファレンス、サイトカイン・ネオプテリン研究会第4回連合研究発表会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-18590196
[Presentation] 高分子微粒子担体へのストローマ細胞の三次元的固定化とその造血支持特性2008
- Author(s)
  湯田幸、相澤信、原田智紀、壷井功、平林幸生、八田善弘、竹内仁、安田昌弘
- Organizer
  第70回日本血液学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-18590196
[Presentation] 加齢に伴う造血間質細胞の機能低下による炎症時の肥満細胞造血反応は低下する2007
- Author(s)
  壷井功、原田智紀、平林容子、菅野純、井上達、相澤信
- Organizer
  第30回日本基礎老化学会総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-18590196
[Presentation] SAM-P1加齢に伴いB細胞造血は造血間質細胞のIL-7とTGF-βの産生低下により抑制的平衡状態へ移行する2007
- Author(s)
  壷井功、原田智紀、平林容子、菅野純、井上達、相澤信
- Organizer
  第22回老化促進モデルマウス研究協議会
- Place of Presentation
  酒田
- Data Source
  KAKENHI-PROJECT-18590196
[Presentation] 肥満細胞造血に対するネオプテリンの効果日本プテリジンカンファレンス、サイトカイン・ネオプテリン研究会2007
- Author(s)
  原田智紀, 壷井功, 大島秀規, 越永守道, 相澤信
- Organizer
  第3回連合研究発表会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-18590196
[Presentation] ネオプテリンの肥満細胞造血に対する影響2007
- Author(s)
  原田智紀、壷井功、越永守道、相澤信
- Organizer
  第112回日本解剖学会総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-18590196
[Presentation] ネオププテリンのストローマ細胞を介する肥満細胞造血制御2007
- Author(s)
  壷井功、原田智紀、平林容子、菅野純、井上達、相澤信
- Organizer
  第69回日本血液学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-18590196
[Presentation] 加齢に伴う造血間質細胞の機能低下により炎症時の肥満細胞造血反応は低下する2007
- Author(s)
  壷井功、原田智紀、平林容子、菅野純、井上達、相沢信
- Organizer
  第30回日本基礎老化学会
- Place of Presentation
  札幌
- Year and Date
  2007-06-22
- Data Source
  KAKENHI-PROJECT-18590196
[Presentation] 加齢に伴いB細胞造血は造血間質細胞のIL-7とTGF-βの産生低下により抑制的平衡状態に移行する2007
- Author(s)
  壷井功、原田智紀、平林容子、菅野純、井上達、相沢信
- Organizer
  第22回老化促進モデルマウス(SAM)研究協議会
- Place of Presentation
  秋田
- Year and Date
  2007-07-26
- Data Source
  KAKENHI-PROJECT-18590196
[Presentation] ネオプテリンのストローマ細胞を介する肥満細胞造血抑制2007
- Author(s)
  壷井功、原田智紀、平林容子、菅野純、井上達、相沢信
- Organizer
  第69回日本血液学会総会
- Place of Presentation
  横浜
- Year and Date
  2007-10-11
- Data Source
  KAKENHI-PROJECT-18590196
[Presentation] ネオプテリンはストローマ細胞のサイトカイン産生を介してB細胞造血を抑制する2006
- Author(s)
  南明宏、原田智紀、壷井功、相澤信
- Organizer
  第471回日大医学会例会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-18590196
[Presentation] ネオプテリンはストローマ細胞のサイトカイン産生を介してB細胞造血を抑制する日本プテリジンカンファレンスサイトカイン・ネオプテリン研究会2006
- Author(s)
  原田智紀、壷井功、相澤信
- Organizer
  第2回連合研究発表会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-18590196
[Presentation] ネオプテリンはストローマ細胞のサイトカイン産生を介して脾臓の肥満前駆細胞の貯蔵プ-ルを増大させる2006
- Author(s)
  福元俊孝、原田智紀、壷井功、相澤信
- Organizer
  第471回日大医学会例会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-18590196
[Presentation] 造血細胞分化における有機カチオントランスポーターOCTN1発現と意義2006
- Author(s)
  原田智紀、神戸栄美子、八田善弘、壷井功、相澤信、前田智司、玉井郁已
- Organizer
  第68回日本血液学会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-18590196
[Presentation] Preserved polycythemia in mice under long-term hypoxia
- Author(s)
  Harada T, Tsuboi I, Naito M, Kosaku K, Hara H, Aizawa S.
- Organizer
  第120回日本解剖学会総会・全国学術集会
- Place of Presentation
  神戸国際会議場（兵庫県・神戸市）
- Year and Date
  2015-03-21 – 2015-03-23
- Data Source
  KAKENHI-PROJECT-24590262

1. TAMAI Ikumi (20155237)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
2. KANNO Hitoshi (70221207)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. NAKANISHI Takeo (30541742)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. MIWA Shiro (40034954)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. NAKAGAWA Shigeki (40059465)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. OYAIZU Naoki (00282773)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. KOIZUMI Tsutomu (40126579)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. MUGISHIMA Hideo (80183648)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. TSUJI Kouichiro (50179991)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. CHIN Motoaki (50277422)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 外山圭助 (00051293)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 金兌貞 (70074507)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 中野優 (70192226)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 前田智司 (60303294)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
15. 大橋晶子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 安田昌弘

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 平林容子

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
18. 原田智紀

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 日野浩嗣

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 宮澤啓介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 森谷昇太

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 風間宏美

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 平本正樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 高野直治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

AIZAWA Shin 相沢 信

相澤 信 アイザワ シン

相沢 信 アイザワ シン

Research Projects

Research Products

Co-Researchers

Distribution and hematopoietic regulatory function of stromal cells in hematopoietic microenvironmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Distribution and hematopoietic regulatory function of stromal cells in hematopoietic microenvironmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regulation of hematopoiesis by bone marrow stromal cells in three-dimensional envirnmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

New rational for chemotherapy targeting transporters expressed in cancer stem cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A study for the role of bone marrow stromal cells in hematopoietic regulationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A study for the constitution and the hematopoietic regulatory mechanism of bone marrow microenvironment in vivoPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

トランスポーター発現プロファイルに基づく細胞分化・増殖制御手法

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A study for the mechanism of hematopoietic regulation by bone marrow stromal cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

MOLECULAR MECHANISMS OF ACCELERATED ERYTHROID APOPTOSIS DUE TO A GLYCOLYTIC ENZYME DEFECT

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A study for the mechanism of negative hematopoietic regulation by bone marrow microenvironment.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study for the mechanism of hematopoietic regulation by bone marrow microenvironmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Physiological significance of pyruvate kinase isozymes in erythrocyte.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Biological characteristics of cord blood stem cell and establishment of in vitro assay of human hematopoietic stem cells

Principal Investigator

AIZAWA Shin 相沢信

相澤信アイザワシン

相沢信アイザワシン