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Kobayashi Kunihiko  小林 国彦

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… Alternative Names

小林 国彦  コバヤシ クニヒコ

KOBAYASHI Kunihiko  小林 国彦

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Researcher Number 30205455
Other IDs
Affiliation (Current) 2025: 埼玉医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help 2016 – 2023: 埼玉医科大学, 医学部, 教授
2006: 国立保健医療科学院, 助教授
2005 – 2006: 埼玉医科大学, 第2内科学, 助教授
1988: 日本医科大学, 医学部, 助手
Review Section/Research Field
Except Principal Investigator
Respiratory organ internal medicine / Basic Section 52010:General internal medicine-related / Public health/Health science
Keywords
Except Principal Investigator
QOL / 放射線治療 / 乳がん / HRQOL20 / EORTC QLQ-C30 / 肺癌 / 抗癌剤 / がん患者 / アドヒアランス / CD4T細胞 … More / 抗PD-1抗体 / T細胞免疫モニタリング / 制御性T細胞 / CD4 T細胞エフェクター / CD62LlowCD4 T細胞 / CD62Llow CD4 T細胞 / 末梢血T細胞クラスター / 免疫チェックポイント阻害薬治療 / Treg / CD62L / 末梢血バイオマーカー / CD4 T細胞 / PD-1 / 免疫チェックポイント阻害薬 / 免疫学 / 癌 / T細胞免疫 / 抗がん剤治療 / エフェクターT細胞 / 腫瘍免疫 / 免疫チェックポイント / PFS / 末梢血単核球 / 小細胞肺癌 / 生活の質(QOL) / 化学療法 / 肺がん / applicability / evaluation / multicultural / equivalence / Scoring method / 文化差 / アウトカム指標 / 適用可能性 / 評価 / 多文化 / 同等性 / スコア変換 / corticosteroid / 養子免疫療法 / Lymphokine activated killer(LAK)cell Less
  • Research Projects

    (6 results)
  • Research Products

    (25 results)
  • Co-Researchers

    (15 People)
  •  長期治療をともなう乳がん患者の治療アドヒアランスに及ぼす要因と治療継続への影響

    • Principal Investigator
      松田 彩子
    • Project Period (FY)
      2019 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52010:General internal medicine-related
    • Research Institution
      National Institute of Public Health
      Teikyo University
  •  Study on a type of chemotherapy regimen that induces immune status into response pattern for anti-PD-1 antibody in small lung cancer patients

    • Principal Investigator
      Nishihara Fuyumi
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Saitama Medical University
  •  Development of Breakthrough Immune Checkpoint Inhibitory Therapy Using Novel Immunological Biomarkers

    • Principal Investigator
      KAGAMU HIROSHI
    • Project Period (FY)
      2017 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Saitama Medical University
  •  Study of the QOL monitoring of the cancer patient

    • Principal Investigator
      Kubota Kaoru
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Nippon Medical School
  •  Outcome evaluation in health science : Cross-cultural equivalence in the quality of life scoring procedure

    • Principal Investigator
      YAMAOKA Kazue
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Public health/Health science
    • Research Institution
      The National Institute of Public Health
  •  延命効果向上を目指した化学療法と養子免疫療法の適切な併用条件の確立に関する研究

    • Principal Investigator
      仁井谷 久暢
    • Project Period (FY)
      1988
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Nippon Medical School

All 2021 2020 2019 2018 2017

All Journal Article Presentation

  • [Journal Article] Efficacy and Feasibility of Programmed Death-1/Programmed Death Ligand-1 Blockade Therapy in Non-Small Cell Lung Cancer Patients With High Antinuclear Antibody Titers.2021

    • Author(s)
      Mouri, A., K. Kaira, O. Yamaguchi, K. Hashimoto, Y. Miura, A. Shiono, S. Shinomiya, T. Akagami, H. Imai, K. Kobayashi, and H. Kagamu.
    • Journal Title

      Front Oncol.

      Volume: 11 Pages: 610952-610952

    • DOI

      10.3389/fonc.2021.610952

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17H04184
  • [Journal Article] Pretreatment Glasgow prognostic score predicts survival among patients with high PD-L1 expression administered first-line pembrolizumab monotherapy for non-small cell lung cancer.2021

    • Author(s)
      Imai, H., T. Kishikawa, H. Minemura, Y. Yamada, T. Ibe, O. Yamaguchi, A. Mouri, Y. Hamamoto, K. Kanazawa, T. Kasai, K. Kaira, T. Kaburagi, K. Minato, K. Kobayashi, and H. Kagamu.
    • Journal Title

      Cancer Med.

      Volume: 10 Issue: 20 Pages: 6971-6984

    • DOI

      10.1002/cam4.4220

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17H04184
  • [Journal Article] Post-Progression Survival Influences Overall Survival among Patients with Advanced Non-Small Cell Lung Cancer Undergoing First-Line Pembrolizumab Monotherapy.2021

    • Author(s)
      Imai, H., T. Kishikawa, H. Minemura, Y. Yamada, T. Ibe, K. Mori, O. Yamaguchi, A. Mouri, Y. Hamamoto, K. Kanazawa, T. Kasai, K. Kaira, T. Kaburagi, K. Minato, K. Kobayashi, and H. Kagamu.
    • Journal Title

      Oncology.

      Volume: 99 Issue: 9 Pages: 562-570

    • DOI

      10.1159/000516745

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17H04184
  • [Journal Article] Effect of Systemic Steroid Use for Immune-Related Adverse Events in Patients with Non-Small Cell Lung Cancer Receiving PD-1 Blockade Drugs.2021

    • Author(s)
      Mouri, A., K. Kaira, O. Yamaguchi, K. Hashimoto, Y. Miura, A. Shiono, S. Shinomiya, H. Imai, K. Kobayashi, and H. Kagamu.
    • Journal Title

      J Clin Med.

      Volume: 10 Issue: 16 Pages: 3744-3744

    • DOI

      10.3390/jcm10163744

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17H04184
  • [Journal Article] CD4(+) T-cell Immunity in the Peripheral Blood Correlates with Response to Anti-PD-1 Therapy.2020

    • Author(s)
      Kagamu H, Kitano S, Yamaguchi O, Yoshimura K, Horimoto K, Kitazawa M, et al.
    • Journal Title

      Cancer Immunol Res

      Volume: 8 Issue: 3 Pages: 334-344

    • DOI

      10.1158/2326-6066.cir-19-0574

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H04184, KAKENHI-PROJECT-17K09665
  • [Journal Article] D4(+) T-cell Immunity in the Peripheral Blood Correlates with Response to Anti-PD-1 Therapy.2020

    • Author(s)
      Kagamu, H., Kitano, S., Yamaguchi, O., Yoshimura, K., Horimoto, K., Kitazawa, M., Fukui, K., Shiono, A., Mouri, A., Nishihara, F., Miura, Y., Hashimoto, K., Murayama, Y., Kaira, K., and Kobayashi, K.
    • Journal Title

      Cancer Immunol Res

      Volume: 8 Pages: 334-344

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04184
  • [Journal Article] Chemoradiotherapy followed by durvalumab in patients with unresectable advanced non‐small cell lung cancer: Management of adverse events2020

    • Author(s)
      Miura Yu、Mouri Atsuto、Kaira Kyoichi、Yamaguchi Ou、Shiono Ayako、Hashimoto Kosuke、Nishihara Fuyumi、Shinomiya Shun、Akagami Tomoe、Murayama Yoshitake、Abe Takanori、Noda Shin‐ei、Kato Shingo、Kobayashi Kunihiko、Kagamu Hiroshi
    • Journal Title

      Thoracic Cancer

      Volume: 11 Issue: 5 Pages: 1280-1287

    • DOI

      10.1111/1759-7714.13394

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K09665, KAKENHI-PROJECT-17H04184
  • [Journal Article] Radiotherapy is an independent prognostic marker of favorable prognosis in non‐small cell lung cancer patients after treatment with the immune checkpoint inhibitor, nivolumab2019

    • Author(s)
      Yamaguchi Ou、Kaira Kyoichi、Hashimoto Kosuke、Mouri Atsuto、Miura Yu、Shiono Ayako、Nishihara Fuyumi、Murayama Yoshitake、Noda Shin‐ei、Kato Shingo、Kobayashi Kunihiko、Kagamu Hiroshi
    • Journal Title

      Thoracic Cancer

      Volume: 10 Issue: 4 Pages: 992-1000

    • DOI

      10.1111/1759-7714.13044

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H04184, KAKENHI-PROJECT-17K16058, KAKENHI-PROJECT-17K09665
  • [Journal Article] Different incidence of interstitial lung disease according to different kinds of EGFR‐tyrosine kinase inhibitors administered immediately before and/or after anti‐PD‐1 antibodies in lung cancer2019

    • Author(s)
      Uchida Takahiro、Kaira Kyoichi、Yamaguchi Ou、Mouri Atsuto、Shiono Ayako、Miura Yu、Hashimoto Kosuke、Nishihara Fuyumi、Murayama Yoshitake、Kobayashi Kunihiko、Kagamu Hiroshi
    • Journal Title

      Thoracic Cancer

      Volume: 10 Issue: 4 Pages: 975-979

    • DOI

      10.1111/1759-7714.13039

    • Data Source
      KAKENHI-PROJECT-17H04184
  • [Journal Article] Combination Therapy with Carboplatin and Paclitaxel for Small Cell Lung Cancer2019

    • Author(s)
      Atsuto Mouri, Ou Yamaguchi, Sachiko Miyauchi, Ayako Shiono, Harue Utsugi, Fuyumi Nishihara, Yoshitake Murayama, Hiroshi Kagamu, Kunihiko Kobayashi
    • Journal Title

      Respiratory investigation

      Volume: 57 Issue: 1 Pages: 34-39

    • DOI

      10.1016/j.resinv.2018.09.004

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K16058, KAKENHI-PROJECT-17K09665
  • [Journal Article] Improved efficacy of ramucirumab plus docetaxel after nivolumab failure in previously treated non‐small cell lung cancer patients2019

    • Author(s)
      Shiono Ayako、Kaira Kyoichi、Mouri Atsuto、Yamaguchi Ou、Hashimoto Kosuke、Uchida Takahiro、Miura Yu、Nishihara Fuyumi、Murayama Yoshitake、Kobayashi Kunihiko、Kagamu Hiroshi
    • Journal Title

      Thoracic Cancer

      Volume: 10 Issue: 4 Pages: 775-781

    • DOI

      10.1111/1759-7714.12998

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H04184, KAKENHI-PROJECT-17K16058, KAKENHI-PROJECT-17K09665
  • [Journal Article] Clinical difference between discontinuation and retreatment with nivolumab after immune-related adverse events in patients with lung cancer2019

    • Author(s)
      Mouri Atsuto、Kaira Kyoichi、Yamaguchi Ou、Shiono Ayako、Miura Yu、Hashimoto Kosuke、Nishihara Fuyumi、Murayama Yoshitake、Kobayashi Kunihiko、Kagamu Hiroshi
    • Journal Title

      Cancer Chemotherapy and Pharmacology

      Volume: 84 Issue: 4 Pages: 873-880

    • DOI

      10.1007/s00280-019-03926-y

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K09665
  • [Journal Article] Updated survival outcomes of NEJ005/TCOG0902: a randomised phase II study of concurrent versus sequential alternating gefitinib and chemotherapy in previously untreated non-small cell lung cancer with sensitive EGFR mutations.2018

    • Author(s)
      Oizumi S, Sugawara S, Minato K, Harada T, Inoue A, Fujita Y, Maemondo M, Watanabe S, Ito K, Gemma A, Demura Y, Fukumoto S, Isobe H, Kinoshita I, Morita S, Kobayashi K, Hagiwara K, Aiba K, Nukiwa T.
    • Journal Title

      ESMO Open

      Volume: 3(2) Issue: 2 Pages: e000313-e000313

    • DOI

      10.1136/esmoopen-2017-000313

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09562, KAKENHI-PROJECT-17K09639, KAKENHI-PROJECT-15K09164, KAKENHI-PROJECT-15K09168, KAKENHI-PROJECT-15K09237
  • [Journal Article] Prognostic Factors and Efficacy of First-Line Chemotherapy in Patients with Advanced Thymic Carcinoma2018

    • Author(s)
      Ko R, Shukuya T, Okuma Y, Tateishi K, Imai H, Iwasawa S, Miyauchi E, Fujiwara A, Sugiyama T, Azuma K, Muraki K, Yamasaki M, Tanaka H, Takashima Y, Soda S, Ishimoto O, Koyama N, Morita S, Kobayashi K, Nukiwa T, Takahashi K; North East Japan Study Group.
    • Journal Title

      Oncologist

      Volume: unknown Issue: 10 Pages: 1210-1217

    • DOI

      10.1634/theoncologist.2017-0586

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K09562, KAKENHI-PROJECT-17K09671, KAKENHI-PROJECT-18K08185, KAKENHI-PROJECT-15K09230
  • [Journal Article] Pulmonary Tumor Embolism Due to Squamous Cell Carcinoma of the Uterine Cervix2018

    • Author(s)
      Okazaki S, Abe T, Takayanagi N, Yasuda M, Sakai F, Kobayashi K, Kato S.
    • Journal Title

      A Case Report. In Vivo

      Volume: 32(2) Pages: 337-343

    • Data Source
      KAKENHI-PROJECT-16K09562
  • [Journal Article] Cross-cultural comparison of breast cancer patients’ Quality of Life in the Netherlands and Japan2017

    • Author(s)
      Fischer M. J.、Inoue K.、Matsuda A.、Kroep J. R.、Nagai S.、Tozuka K.、Momiyama M.、Weijl N. I.、Langemeijer-Bosman D.、Ramai S. R. S.、Nortier J. W. R.、Putter H.、Yamaoka K.、Kubota K.、Kobayashi K.、Kaptein A. A.
    • Journal Title

      Breast Cancer Research and Treatment

      Volume: 166 Issue: 2 Pages: 459-471

    • DOI

      10.1007/s10549-017-4417-z

    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09562
  • [Journal Article] The international phase 4 validation study of the EORTC QLQ-SWB32: A stand-alone measure of spiritual well-being for people receiving palliative care for cancer2017

    • Author(s)
      Vivat B, Young TE, Winstanley J, Arraras JI, Black K, Boyle F, Bredart A, Costantini A, Guo J, Irarrazaval ME, Kobayashi K, Kruizinga R, Navarro M, Omidvari S, Rohde GE, Serpentini S, Spry N, Van Laarhoven HWM, Yang GM; EORTC Quality of Life Group.
    • Journal Title

      Eur J Cancer Care (Engl)

      Volume: 26(6) Issue: 6 Pages: e12697-e12697

    • DOI

      10.1111/ecc.12697

    • Data Source
      KAKENHI-PROJECT-16K09562
  • [Journal Article] The effects of illness beliefs and chemotherapy impact on quality of life in Japanese and Dutch patients with breast or lung cancer2017

    • Author(s)
      Willem A. van der Kloot, Yuka Uchida, Kenichi Inoue, Kunihiko Kobayashi, Kazue Yamaoka, Hans W. R. Nortier, Ad A. Kaptein
    • Journal Title

      Chin Clin Oncol

      Volume: 5(1) Pages: 3-3

    • Data Source
      KAKENHI-PROJECT-16K09562
  • [Journal Article] A highly specific and sensitive massive parallel sequencer-based test for somatic mutations in non-small cell lung cancer.2017

    • Author(s)
      Inoue Y, Shiihara J, Miyazawa H, Ohta H, Higo M, Nagai Y, Kobayashi K, Saijo Y, Tsuchida M, Nakayama M, Hagiwara K.
    • Journal Title

      PLoS One

      Volume: 12(4) Issue: 4 Pages: 1-14

    • DOI

      10.1371/journal.pone.0176525

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K09562, KAKENHI-PROJECT-15K10235, KAKENHI-PROJECT-16K15461
  • [Presentation] 小細胞肺癌治療が抗腫瘍免疫に及ぼす影響2019

    • Author(s)
      西原冬実、四宮俊、橋本康佑、三浦雄、塩野文子、山口央、毛利篤人、村山芳武、解良恭一、小林国彦、各務博
    • Organizer
      第17回日本臨床腫瘍学会学術集会
    • Data Source
      KAKENHI-PROJECT-17K09665
  • [Presentation] Phase II study to evaluate the peripheral blood mononuclear cell biomarker for nivolumab efficacy on previously treated non-small cell lung cancer subjects2019

    • Author(s)
      Yosuke Kawashima, Ou Yamaguchi, Kozuki Toshiyuki, Naoki Furuya, Futoshi Kurimoto, Takae Okuno, Tadaaki Yamada, Kenichiro Komiyama, Ko Ryo, Yoshiaki Nagai, Nobuhisa Ishikawa, Toshiyuki Harada, Kana Watanabe, Seike Masahiro, Kenichi Yoshimura, Kunihiko Kobayashi, Hiroshi Kagamu
    • Organizer
      ESMO
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04184
  • [Presentation] Effector CD4+ T-cell induction by thoracic radiotherapy for NSCLC patients2019

    • Author(s)
      Yu Miura, Koko Kodaira, Megumi Kenmochi, Tomoko Yamashiro, Ou Yamaguchi, Ayako Shiono, Atsuhito Mouri, Fuyumi Nishihara, Shun Shinomiya, Kosuke Hashimoto, Yoshitake Murayama, Kunihiko Kobayashi, Kyoichi Kaira, and Hiroshi Kagamu
    • Organizer
      ESMO
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04184
  • [Presentation] CD4+ T-cell immunity predicted long-surviving NSCLC patients after PD-1 blockade therapy2019

    • Author(s)
      Kyoichi Kaira, Ou Yamaguchi, Atsuto Mouri, Ayako Shiono, Fuyumi Nishihara, Yu Miura, Shun Shinomiya, Kosuke Hashimoto, Yoshitake Murayama, Shigehiko Kitano, Kunihiko Kobayashi, and Hiroshi Kagamu
    • Organizer
      ASCO
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04184
  • [Presentation] 小細胞肺癌標準治療が及ぼす免疫学的影響2018

    • Author(s)
      西原冬実、山口央、毛利篤人、塩野文子、内田貴裕、橋本康佑、三浦雄、村山芳武、解良恭一、小林国彦、各務博
    • Organizer
      日本臨床腫瘍学会
    • Data Source
      KAKENHI-PROJECT-17H04184
  • [Presentation] ニボルマブによるirILDと予後、効果、末梢血CD62Llow CD4+ T細胞との関係2018

    • Author(s)
      山口央、毛利篤人、塩野文子、内田貴裕、橋本康佑、西原冬実、三浦雄、村山芳武、解良恭一、小林国彦、各務博
    • Organizer
      日本肺癌学会
    • Data Source
      KAKENHI-PROJECT-17H04184
  • 1.  INOUE Kenich (70443059)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 4 results
  • 2.  YAMAOKA Kazue (50091038)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 3.  KAGAMU HIROSHI (30418686)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 17 results
  • 4.  松田 彩子 (30618997)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 5.  OGHOSHI Kyoji (30112775)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  Kubota Kaoru (70501857)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 7.  Nishihara Fuyumi (60406478)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 8.  仁井谷 久暢 (10076945)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  倉根 修二 (70186493)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  渋谷 昌彦 (50142534)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  青山 昭徳 (60089688)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  矢野 侃 (00133447)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  石田 博徳 (70274587)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  萩原 弘一 (00240705)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  毛利 篤人
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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