MUGURUMA Keiko 六車恵子

Researcher Number	30209978
Other IDs
Affiliation (based on the past Project Information) *help	2018 – 2024: 関西医科大学, 医学部, 教授 2015 – 2017: 国立研究開発法人理化学研究所, 多細胞システム形成研究センター, 専門職研究員 2014: 独立行政法人理化学研究所, 多細胞システム形成研究センター, 専門職研究員 2013: 独立行政法人理化学研究所, 発生・再生科学総合研究センター, 専門職研究員 2011 – 2012: 独立行政法人理化学研究所, 器官発生研究グループ, 専門職研究員
Review Section/Research Field	Principal Investigator Developmental biology / Basic Section 90110:Biomedical engineering-related / Complex systems / Medium-sized Section 90:Biomedical engineering and related fields / Basic Section 46020:Anatomy and histopathology of nervous system-related / Biological Sciences Except Principal Investigator Basic Section 51030:Pathophysiologic neuroscience-related / Medium-sized Section 90:Biomedical engineering and related fields / Medium-sized Section 52:General internal medicine and related fields / Basic Section 90110:Biomedical engineering-related
Keywords	Principal Investigator 小脳 / 神経分化 / プルキンエ細胞 / iPS細胞 / 三次元培養 / 自己組織化 / 神経回路 / オルガノイド / 脳オルガノイド / ヒト多能性幹細胞 … More / 自己組織能 / ES細胞・iPS細胞 / アセンブロイド / タイムラプスイメージング / 多能性幹細胞 / 細胞形態・回路構造 / 細胞形態 / 神経活動 / 皮質構築異常 / てんかん / 領域間神経ネットワーク / 複合型脳オルガノイド / イメージング / 神経ネットワーク / 神経発生 / 大脳 / 小脳プルキンエ細胞 / 細胞脆弱性 / 大脳神経 / 脊髄小脳変性症 / 神経変性疾患 / 神経変性 / 三次元立体培養 / 3次元培養 / in vivo imaging / 細胞移動 … More Except Principal Investigator 脳オルガノイド / 多能性幹細胞 / iPS細胞 / 筋萎縮性側索硬化症 / 画像解析 / 多次元イメージング / 大脳皮質 / オルガノイドインテリジェンス / 疾患モデル / 基底核オルガノイド / 大脳オルガノイド / 大脳皮質基底核変性症 / オプティニューリン / ALS / 筋委縮性側索硬化症 / 神経変性 / リピート / 眼咽頭遠位型ミオパチー / 原因遺伝子 / ロングリードシーケンサー Less

オルガノイドインテリジェンスの構築によるヒト脳機能の解明
- Principal Investigator
  
  玉田篤史
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  Kansai Medical University
患者iPS細胞を用いたオプティニューリン変異による神経変性機構の解明
- Principal Investigator
  
  木村俊哉
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Kansai Medical University
大脳皮質基底核変性症の疾患モデル構築と病態解明
- Principal Investigator
  
  玉田篤史
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Kansai Medical University
Identification and analysis of novel genes of amyotrophic lateral screlosis
- Principal Investigator
  
  川上秀史
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Hiroshima University
Ontogeny-recapitulating generation of human pluripotent stem cell-derived cerebellar organoidsPrincipal Investigator
- Principal Investigator
  
  MUGURUMA Keiko
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 90110:Biomedical engineering-related
- Research Institution
  Kansai Medical University
Construction and analysis of in vitro brain tissues for elucidation of human brain functions
- Principal Investigator
  
  TAMADA Atsushi
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  Kansai Medical University
Investigation of human brain function with organoid networkPrincipal Investigator
- Principal Investigator
  
  MUGURUMA Keiko
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  Kansai Medical University
Analysis and control of singularity structures triggering epileptic seizurePrincipal Investigator
- Principal Investigator
  
  六車恵子
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Kansai Medical University
Development of methods for construction and automated analysis of human brain organoids
- Principal Investigator
  
  TAMADA Atsushi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 90110:Biomedical engineering-related
- Research Institution
  Kansai Medical University
Vulnerability of cerebellar and cerebral cortical neurons in neurodegenerative diseasesPrincipal Investigator
- Principal Investigator
  
  MUGURUMA Keiko
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 46020:Anatomy and histopathology of nervous system-related
- Research Institution
  Kansai Medical University
An analysis of cerebellar histogenesis generated from human pluripotent stem cellsPrincipal Investigator
- Principal Investigator
  
  Muguruma Keiko
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Developmental biology
- Research Institution
  Institute of Physical and Chemical Research
Self-organization of cerebellar tissue in 3D culture of human pluripotent stem cellsPrincipal Investigator
- Principal Investigator
  
  MUGURUMA Keiko
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Developmental biology
- Research Institution
  The Institute of Physical and Chemical Research
プルキンエ細胞の秩序ある配置のための細胞と場の動的相互作用Principal Investigator
- Principal Investigator
  
  六車恵子
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The Institute of Physical and Chemical Research

[Book] Cerebellum as a CNS Hub2021
- Author(s)
  Tamada Atsushi、Muguruma Keiko
- Total Pages
  16
- Publisher
  Springer International Publishing
- ISBN
  9783030758172
- Data Source
  KAKENHI-PROJECT-19H04458
[Book] 決定版　オルガノイド実験スタンダード「II-7. 小脳オルガノイドの作製とプルキンエ細胞への誘導, 」2019
- Author(s)
  六車恵子,（編集）佐藤俊朗、武部貴則、永樂元次
- Total Pages
  372
- Publisher
  羊土社
- ISBN
  9784758122399
- Data Source
  KAKENHI-PROJECT-18H02535
[Book] 難病と在宅ケア, iPS細胞を活用した脊髄小脳変性症研究の現状2018
- Author(s)
  六車恵子
- Total Pages
  64
- Publisher
  日本プランニングセンター
- Data Source
  KAKENHI-PROJECT-18H02535
[Book] Organ Regeneration2017
- Author(s)
  Muguruma K (Ed. Tsuji T.)
- Total Pages
  248
- Publisher
  Humana Press
- ISBN
  9781493969494
- Data Source
  KAKENHI-PROJECT-15K07089
[Book] 運動失調のみかた、考えかた2017
- Author(s)
  六車恵子（宇川義一編）
- Total Pages
  358
- Publisher
  中外医学社
- ISBN
  9784498228900
- Data Source
  KAKENHI-PROJECT-15K07089
[Book] Annual Review 神経20172017
- Author(s)
  六車恵子
- Total Pages
  279
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-15K07089
[Book] Annual Review神経20172017
- Author(s)
  六車恵子
- Total Pages
  281
- Publisher
  中外医学社
- ISBN
  9784498228764
- Data Source
  KAKENHI-PROJECT-15K07089
[Book] Clinical Neuroscience（臨床神経科学）2017
- Author(s)
  六車恵子
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-15K07089
[Journal Article] Deciphering potential vascularization factors of on-chip co-cultured hiPSC-derived cerebral organoids2024
- Author(s)
  Shaji Maneesha、Tamada Atsushi、Fujimoto Kazuya、Muguruma Keiko、Karsten Stanislav L.、Yokokawa Ryuji
- Journal Title
  
  Lab on a Chip
  
  Volume: 24 Issue: 4 Pages: 680-696
- DOI
  10.1039/d3lc00930k
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K18319, KAKENHI-PROJECT-21H03812, KAKENHI-PROJECT-23K24222
[Journal Article] Recapitulation and investigation of human brain development with neural organoids2024
- Author(s)
  Tamada Atsushi、Muguruma Keiko
- Journal Title
  
  IBRO Neuroscience Reports
  
  Volume: 16 Pages: 106-117
- DOI
  10.1016/j.ibneur.2023.12.006
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H03812, KAKENHI-PROJECT-23K24222
[Journal Article] iPS cell technologies toward overcoming neurological diseases2023
- Author(s)
  木村俊哉, 六車恵子
- Journal Title
  
  Folia Pharmacologica Japonica
  
  Volume: 158 Issue: 1 Pages: 57-63
- DOI
  10.1254/fpj.22084
- ISSN
  0015-5691, 1347-8397
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H03812
[Journal Article] CGG repeat expansion in LRP12 in amyotrophic lateral sclerosis2023
- Author(s)
  Kume Kodai Kurashige Takashi Muguruma Keiko Morino Hiroyuki、...Kawakami Hideshi
- Journal Title
  
  The American Journal of Human Genetics
  
  Volume: 110 Issue: 7 Pages: 1086-1097
- DOI
  10.1016/j.ajhg.2023.05.014
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H04818, KAKENHI-PROJECT-21H02718, KAKENHI-PROJECT-21H03812, KAKENHI-PROJECT-23K24996
[Journal Article] Survival and process outgrowth of human iPSC-derived cells expressing Purkinje cell markers in a mouse model for spinocerebellar degenerative disease2023
- Author(s)
  Kamei Takamasa、Tamada Atsushi、Kimura Toshiya、Kakizuka Akira、Asai Akio、Muguruma Keiko
- Journal Title
  
  Experimental Neurology
  
  Volume: 369 Pages: 114511-114511
- DOI
  10.1016/j.expneurol.2023.114511
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07360, KAKENHI-PROJECT-21H03047, KAKENHI-PROJECT-21H03812, KAKENHI-PROJECT-23K24222
[Journal Article] 特集形態形成の統合的理解 Ⅲ.再構成系による理解脳オルガノイドを用いたヒト脳の発生･疾患の理解2022
- Author(s)
  玉田篤史、木村俊哉、次山ルシラ絵美子、六車恵子
- Journal Title
  
  生体の科学
  
  Volume: 73 Issue: 4 Pages: 343-347
- DOI
  10.11477/mf.2425201533
- ISSN
  0370-9531, 1883-5503
- Year and Date
  2022-08-15
- Data Source
  KAKENHI-PROJECT-21K19932, KAKENHI-PROJECT-23K24222
[Journal Article] オルガノイドで解き明かすヒト脳の神秘2022
- Author(s)
  六車恵子
- Journal Title
  
  週刊医学界新聞
  
  Volume: 3492 Pages: 5-5
- Data Source
  KAKENHI-PROJECT-21H03812
[Journal Article] Differentiation of human induced pluripotent stem cells into hypothalamic vasopressin neurons with minimal exogenous signals and partial conversion to the naive state2022
- Author(s)
  Ozaki Hajime、Suga Hidetaka、Sakakibara Mayu、Miyake Natsuki、Miwata Tsutomu、Taga Shiori、Nagai Takashi、Kano Mayuko、Mitsumoto Kazuki、Miyata Takashi、Kobayashi Tomoko、Sugiyama Mariko、Onoue Takeshi、Takagi Hiroshi、Hagiwara Daisuke、Iwama Shintaro、Banno Ryoichi、Iguchi Genzo、Takahashi Yutaka、Arima Hiroshi
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 17381-17381
- DOI
  10.1038/s41598-022-22405-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08555, KAKENHI-PROJECT-21H03812, KAKENHI-PROJECT-20K08859
[Journal Article] 脳オルガノイドを用いたヒト脳の発生・疾患の理解2022
- Author(s)
  玉田篤史, 木村俊哉, 次山ルシラ絵美子, 六車恵子
- Journal Title
  
  生体の科学
  
  Volume: 73(4) Pages: 343-347
- Data Source
  KAKENHI-PROJECT-21H03812
[Journal Article] Modeling of Human Cerebellar Development and Diseases with Pluripotent Stem Cell-Derived Brain Organoids2021
- Author(s)
  Tamada Atsushi、Muguruma Keiko
- Journal Title
  
  Cerebellum as a CNS Hub
  
  Volume: 1 Pages: 61-76
- DOI
  10.1007/978-3-030-75817-2_3
- ISBN
  9783030758165, 9783030758172
- Data Source
  KAKENHI-PROJECT-21H03812
[Journal Article] Restoration of the defect in radial glial fiber migration and cortical plate organization in a brain organoid model of Fukuyama muscular dystrophy2021
- Author(s)
  Taniguchi-Ikeda Mariko、Koyanagi-Aoi Michiyo、Maruyama Tatsuo、Takaori Toru、Hosoya Akiko、Tezuka Hiroyuki、Nagase Shotaro、Ishihara Takuma、Kadoshima Taisuke、Muguruma Keiko、Ishigaki Keiko、Sakurai Hidetoshi、Mizoguchi Akira、Novitch Bennett G.、Toda Tatsushi、Watanabe Momoko、Aoi Takashi
- Journal Title
  
  iScience
  
  Volume: 24 Issue: 10 Pages: 103140-103140
- DOI
  10.1016/j.isci.2021.103140
- NAID
  120007170807
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07614, KAKENHI-PROJECT-21H03812, KAKENHI-PROJECT-21K19457, KAKENHI-PROJECT-20H00526, KAKENHI-PROJECT-23K21430
[Journal Article] Generation of a human induced pluripotent stem cell line, BRCi004-A, derived from a patient with age-related macular degeneration2020
- Author(s)
  Kamata Kazuma、Otsuka Yuki、Imamura Keiko、Oishi Akio、Kondo Takayuki、Suga Mika、Shibukawa Ran、Okanishi Yasue、Sagara Yukako、Tsukita Kayko、Yasukawa Tsutomu、Usui Hideaki、Muguruma Keiko、Tsujikawa Akitaka、Inoue Haruhisa
- Journal Title
  
  Stem Cell Research
  
  Volume: 45 Pages: 101787-101787
- DOI
  10.1016/j.scr.2020.101787
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09929, KAKENHI-PUBLICLY-19H05433, KAKENHI-PROJECT-18H02535, KAKENHI-PROJECT-19K22983
[Journal Article] Generation of a human induced pluripotent stem cell line, BRCi005-A, derived from a Best disease patient with BEST1 mutations2020
- Author(s)
  Kamata Kazuma、Otsuka Yuki、Imamura Keiko、Oishi Akio、Kondo Takayuki、Suga Mika、Shibukawa Ran、Okanishi Yasue、Sagara Yukako、Tsukita Kayko、Yasukawa Tsutomu、Usui Hideaki、Muguruma Keiko、Tsujikawa Akitaka、Inoue Haruhisa
- Journal Title
  
  Stem Cell Research
  
  Volume: 45 Pages: 101782-101782
- DOI
  10.1016/j.scr.2020.101782
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09929, KAKENHI-PUBLICLY-19H05433, KAKENHI-PROJECT-18H02535, KAKENHI-PROJECT-19K22983
[Journal Article] Investigating developmental and disease mechanisms of the cerebellum with pluripotent stem cells2020
- Author(s)
  Tamada Atsushi、Watanabe Shoji、Muguruma Keiko
- Journal Title
  
  Molecular and Cellular Neuroscience
  
  Volume: 107 Pages: 103530-103530
- DOI
  10.1016/j.mcn.2020.103530
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-19H05433, KAKENHI-PROJECT-18H02535, KAKENHI-PROJECT-19H04458, KAKENHI-PROJECT-19K22983
[Journal Article] Self-organizing cortex generated from human iPSCs with combination of FGF2 and ambient oxygen.2018
- Author(s)
  Eguchi N, Sora I, Muguruma K.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 498 Issue: 4 Pages: 729-735
- DOI
  10.1016/j.bbrc.2018.03.049
- NAID
  120006462318
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K07089, KAKENHI-PROJECT-16K15561, KAKENHI-PROJECT-18H02535, KAKENHI-PROJECT-16H06276
[Journal Article] Self-organized cerebellar tissue from human pluripotent stem cells and disease modeling with patient-derived iPSCs2018
- Author(s)
  Muguruma K
- Journal Title
  
  Cerebellum
  
  Volume: 17 Issue: 1 Pages: 37-41
- DOI
  10.1007/s12311-017-0905-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K07089
[Journal Article] 3D culture for self-formation of the cerebellum from human pluripotent stem cells through induction of the isthmic organizer2017
- Author(s)
  Muguruma K
- Journal Title
  
  Methods in Molecular Biology
  
  Volume: 1597 Pages: 31-41
- DOI
  10.1007/978-1-4939-6949-4_3
- ISBN
  9781493969470, 9781493969494
- Open Access
- Data Source
  KAKENHI-PROJECT-15K07089
[Journal Article] Vulnerability of Purkinje Cells Generated from Spinocerebellar Ataxia Type 6 Patient-Derived iPSCs.2016
- Author(s)
  Ishida Y, Kawakami H, Kitajima H, Nishiyama A, Sasai Y, Inoue H, Muguruma K.
- Journal Title
  
  Cell Rep
  
  Volume: 17 Issue: 6 Pages: 1482-1490
- DOI
  10.1016/j.celrep.2016.10.026
- NAID
  120006223645
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26242085, KAKENHI-PROJECT-15K07089
[Journal Article] iPS細胞から立体脳組織への分化誘導と疾患研究2016
- Author(s)
  六車　恵子
- Journal Title
  
  実験医学
  
  Volume: 34 Pages: 551-556
- Data Source
  KAKENHI-PROJECT-15K07089
[Journal Article] ヒト多能性幹細胞の自己組織的分化による小脳組織の構築2015
- Author(s)
  六車　恵子
- Journal Title
  
  細胞工学
  
  Volume: 34(7)
- Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24570242
[Journal Article] Self-organization of polarized cerebellar tissue in 3D culture of human pluripotent stem cells.2015
- Author(s)
  Muguruma K, et al.
- Journal Title
  
  Cell Reports
  
  Volume: 10 Issue: 4 Pages: 537-550
- DOI
  10.1016/j.celrep.2014.12.051
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24570242, KAKENHI-PLANNED-25117006, KAKENHI-PUBLICLY-25123716, KAKENHI-PROJECT-26242085
[Journal Article] A mutation in the low voltage -gated calcium channel CACNA1G alters the physiological properties of the channel, causing spinocerebellar ataxia.2015
- Author(s)
  Morino H., Matsuda Y., Muguruma K., Miyamoto R., Ohsawa R., Ohtake T., Otobe R., Watanabe M., Maruyama H., Hashimoto K., Kawakami H.
- Journal Title
  
  Molecular Brain
  
  Volume: 8 Issue: 1 Pages: 1-9
- DOI
  10.1186/s13041-015-0180-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K07089, KAKENHI-PROJECT-15K15083, KAKENHI-PLANNED-23111008, KAKENHI-PLANNED-25117006, KAKENHI-PROJECT-24220007, KAKENHI-PROJECT-26293211, KAKENHI-PROJECT-26242085
[Journal Article] in vitro recapitulation of neural development using embryonic stem cells: From neurogenesis to histogenesis2012
- Author(s)
  Muguruma K
- Journal Title
  
  Dev. Growth Differ
  
  Volume: 54(3) Pages: 349-357
- NAID
  10031136907
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-23111535
[Journal Article] In vitro recapitulation of neural deveopment using embryonic stem cells: From neurogenesis to histogenesis.2012
- Author(s)
  Muguruma K
- Journal Title
  
  Dev. Growth Differ
  
  Volume: 54(3) Pages: 349-357
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24570242
[Journal Article] In vitro recapitulation of neural development using embryonic stem cells : From neurogenesis to histogenesis2012
- Author(s)
  六車恵子
- Journal Title
  
  Devlop.Growth Differ.
  
  Volume: (in press)
- NAID
  10031136907
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-23111535
[Journal Article] Self-formation of functional adenohypophysis in three-dimensional culture2011
- Author(s)
  Suga H, Oiso Y, et al
- Journal Title
  
  Nature
  
  Volume: 480 Issue: 7375 Pages: 57-62
- DOI
  10.1038/nature10637
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390188, KAKENHI-PUBLICLY-23111534, KAKENHI-PUBLICLY-23111535, KAKENHI-PROJECT-23770237
[Patent] 小脳前駆組織の製造方法2014
- Inventor(s)
  笹井芳樹、六車恵子
- Industrial Property Rights Holder
  理化学研究所
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2014-182758
- Filing Date
  2014-09-08
- Data Source
  KAKENHI-PROJECT-24570242
[Patent] ヒトES細胞用培養容器2012
- Inventor(s)
  笹井芳樹、六車恵子、塚田亮平、田中速雄
- Industrial Property Rights Holder
  理化学研究所、住友ベークライト株式会社
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2012-131430
- Filing Date
  2012-06-08
- Data Source
  KAKENHI-PROJECT-24570242
[Patent] ヒトES細胞用培養容器2012
- Inventor(s)
  笹井芳樹、六車恵子、塚田亮平、田中速雄
- Industrial Property Rights Holder
  理化学研究所、住友ベークライト株式会社
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2012-131430
- Filing Date
  2012-06-08
- Data Source
  KAKENHI-PUBLICLY-23111535
[Presentation] ヒトiPS細胞由来小脳前駆細胞の小脳変性疾患モデルマウスへの移植2023
- Author(s)
  亀井孝昌、玉田篤史、木村俊哉、六車恵子
- Organizer
  第46回日本神経科学大会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24222
[Presentation] 中枢神経系のオルガノイドの作製とその応用2023
- Author(s)
  六車恵子
- Organizer
  第65回歯科基礎医学会学術大会日本学術会議シンポジウム（市民公開講座）
- Invited
- Data Source
  KAKENHI-PROJECT-21H03812
[Presentation] 多能性幹細胞由来の神経オルガノイドを用いたヒトの発生と疾患のモデル化2023
- Author(s)
  六車恵子
- Organizer
  第16回ナノメディシン国際シンポジウム
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H03812
[Presentation] CGG repeat expansion in LRP12 in amyotrophic lateral sclerosis2023
- Author(s)
  Kodai Kume, Takashi Kurashige, Keiko Muguruma, Hideshi Kawakami
- Organizer
  Neuroscience 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H04818
[Presentation] ヒト iPS細胞由来小脳前駆細胞の小脳変性疾患モデルマウスへの移植2023
- Author(s)
  亀井孝昌、玉田篤史、木村俊哉、六車恵子
- Organizer
  第46回日本神経科学大会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H03812
[Presentation] LRP12 の CGG リピート伸長は筋萎縮性側索硬化症の原因となる2023
- Author(s)
  久米広大、倉重毅志、六車恵子、川上秀史
- Organizer
  第64回日本神経病理学会総会学術研究会/第66回日本神経化学会大会合同大会,
- Invited
- Data Source
  KAKENHI-PROJECT-21H04818
[Presentation] CGG repeat expansion in LRP12 in amyotrophic lateral sclerosis2023
- Author(s)
  久米広大、倉重毅志、六車恵子、川上秀史
- Organizer
  日本人類遺伝学会第68回大会
- Data Source
  KAKENHI-PROJECT-21H04818
[Presentation] iPS細胞を用いた神経疾患研究2023
- Author(s)
  六車恵子
- Organizer
  第46回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-21H03812
[Presentation] 多能性幹細胞を用いた脳発生・神経疾患研究2022
- Author(s)
  六車恵子
- Organizer
  第72回日本薬学会関西支部総会・大会
- Invited
- Data Source
  KAKENHI-PROJECT-21H03812
[Presentation] Construction of brain tissues from human pluripotent stem cells for investigating of neurological disease and brain development2022
- Author(s)
  Keiko Muguruma
- Organizer
  The 95th Annual Meeting of the Japanese Pharmacological Society
- Invited
- Data Source
  KAKENHI-PROJECT-21H03812
[Presentation] Modeling of human cerebellar development and diseases with iPSC-derived brain organoids2021
- Author(s)
  Keiko Muguruma
- Organizer
  The 44th Annual Meeting of the Japan Neuroscience Sciety, The 1st CTK International Meeting
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H03812
[Presentation] iPS細胞研究から見た運動失調治療の可能性2021
- Author(s)
  六車恵子
- Organizer
  第62回日本神経学会学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-21H03812
[Presentation] iPS細胞を用いた神経疾患研究2021
- Author(s)
  六車恵子
- Organizer
  第117回日本精神神経学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-21H03812
[Presentation] 多能性幹細胞の試験管内神経分化2020
- Author(s)
  六車恵子
- Organizer
  日本薬学会
- Invited
- Data Source
  KAKENHI-PUBLICLY-19H05433
[Presentation] 多能性幹細胞の試験管内神経分化2020
- Author(s)
  六車恵子
- Organizer
  日本薬学会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02535
[Presentation] 多能性幹細胞の試験管内神経分化2020
- Author(s)
  六車恵子
- Organizer
  日本薬学会
- Invited
- Data Source
  KAKENHI-PROJECT-19K22983
[Presentation] iPS細胞を用いた基礎研究2020
- Author(s)
  六車恵子
- Organizer
  日本臨床神経生理学会学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02535
[Presentation] iPS細胞を用いた基礎研究2020
- Author(s)
  六車恵子
- Organizer
  日本臨床神経生理学会学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-19K22983
[Presentation] iPS細胞を用いた基礎研究2020
- Author(s)
  六車恵子
- Organizer
  日本臨床神経生理学会学術大会
- Invited
- Data Source
  KAKENHI-PUBLICLY-19H05433
[Presentation] Self-organizing cortex generated from human iPSCs with combination of FGF2 and ambient oxygen2018
- Author(s)
  Eguchi N, Sora I, Muguruma K
- Organizer
  WFSBP Asia Pacific Regional Congress of Biological Psychiatry
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02535
[Presentation] Self-organizing cortex generated from human iPSCs with combination of FGF2 and ambient oxygen2018
- Author(s)
  Eguchi N, Sora I, Muguruma K
- Organizer
  第40回日本生物学的精神医学会　第61回日本神経化学会大会合同年会
- Data Source
  KAKENHI-PROJECT-18H02535
[Presentation] Investigation of ontogenesis and pathogenesis with self-organized brain structure from human iPS cells2018
- Author(s)
  Keiko Muguruma
- Organizer
  The 18th World Congress of Basic and Clinical Pharmacology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07089
[Presentation] Investigation of ontogenesis and pathogenesis with self-organized brain structure from iPS cells.2018
- Author(s)
  Keiko Muguruma
- Organizer
  The 18th World Congress of Basic and Clinical Pharmacology (WCP2018)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02535
[Presentation] Construction of iPSC-derived functional brain tissue for investigation of disease mechanisms2018
- Author(s)
  Keiko Muguruma
- Organizer
  2018 Keystone Symposia in iPSCs
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07089
[Presentation] in vitro models of cerebellar development and spinocerebellar degeneration utilizing human iPSCs.2018
- Author(s)
  Keiko Muguruma
- Organizer
  The 75th Fujihara Seminar
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02535
[Presentation] 多能性幹細胞からの試験管内神経分化2018
- Author(s)
  六車恵子
- Organizer
  理研BRCセミナー
- Invited
- Data Source
  KAKENHI-PROJECT-18H02535
[Presentation] Disease modeling with patient derived iPS cells.2017
- Author(s)
  Keiko Muguruma
- Organizer
  SRC 2017 8th International Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07089
[Presentation] 疾患iPS細胞由来の3次元立体大脳組織を活用したてんかん研究の展望2017
- Author(s)
  六車恵子
- Organizer
  第51回日本てんかん学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-15K07089
[Presentation] Investigation of neurodegenerative disease utilizing patient-specific iPS cells.2017
- Author(s)
  Keiko Muguruma
- Organizer
  SELECT BIO Advances in Drug Discovery 2017
- Place of Presentation
  Genome Campus Conference Centre (Cambridge, UK)
- Year and Date
  2017-03-07
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07089
[Presentation] 小脳を作る2016
- Author(s)
  六車　恵子
- Organizer
  第6回小脳研究会　学術集会・総会
- Place of Presentation
  東京
- Year and Date
  2016-01-08
- Invited
- Data Source
  KAKENHI-PROJECT-15K07089
[Presentation] 患者由来iPS細胞を活用した脊髄小脳変性症の疾患モデル開発2016
- Author(s)
  六車恵子
- Organizer
  第57回日本神経学会学術大会
- Place of Presentation
  神戸ポートピアホテル（兵庫県神戸市）
- Year and Date
  2016-05-20
- Invited
- Data Source
  KAKENHI-PROJECT-15K07089
[Presentation] 多能性幹細胞の小脳細胞分化と疾患モデリング2016
- Author(s)
  六車　恵子
- Organizer
  第15回日本再生医療学会総会　シンポジウム
- Place of Presentation
  大阪
- Year and Date
  2016-03-19
- Invited
- Data Source
  KAKENHI-PROJECT-15K07089
[Presentation] 試験管内で小脳を作る：iPS細胞を活用した疾患研究2016
- Author(s)
  六車恵子
- Organizer
  第10回パーキンソン病・運動障害疾患コングレス
- Place of Presentation
  京都ホテルオークラ（京都府京都市）
- Year and Date
  2016-10-07
- Invited
- Data Source
  KAKENHI-PROJECT-15K07089
[Presentation] ヒトES/iPS細胞の自己組織課による小脳形成2016
- Author(s)
  六車恵子
- Organizer
  岐阜大・岐阜薬大連携　第13回岐阜神経研究会
- Place of Presentation
  岐阜大学医学部（岐阜県岐阜市）
- Year and Date
  2016-06-15
- Invited
- Data Source
  KAKENHI-PROJECT-15K07089
[Presentation] 患者由来iPS細胞を活用した神経変性疾患研究2016
- Author(s)
  六車恵子
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-11-30
- Invited
- Data Source
  KAKENHI-PROJECT-15K07089
[Presentation] Disease modeling with patient derived iPSCs.2016
- Author(s)
  Keiko Muguruma
- Organizer
  Cell Symposia 10 Years of iPSCs
- Place of Presentation
  Claremont Hotel & Spa (Barkeley, CA, USA)
- Year and Date
  2016-09-27
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07089
[Presentation] Self-organization of polarized cerebellar tissue in 3D culture of human pluripotent stem cells.2015
- Author(s)
  Muguruma K., Kawakami H., Hashimoto K., Sasai Y.
- Organizer
  Society for Neuroscience Annual Meeting 2015
- Place of Presentation
  Chicago, USA
- Year and Date
  2015-10-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07089
[Presentation] Self-organization of polarized cerebellar tissue in 3D culture of human pluripotent stem cells.2015
- Author(s)
  Muguruma K., Nishiyama A., Kawakami H., Hashimoto K., Sasai Y.
- Organizer
  The 38th Annual Meeting of the Japan Neuroscience Society
- Place of Presentation
  Kobe, Japan
- Year and Date
  2015-07-28
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07089
[Presentation] iPS細胞を用いた大脳・小脳希少難治性疾患研究への取り組み2015
- Author(s)
  六車　恵子
- Organizer
  日本動物実験代替法学会第28回大会シンポジウム
- Place of Presentation
  横浜
- Year and Date
  2015-12-12
- Invited
- Data Source
  KAKENHI-PROJECT-15K07089
[Presentation] Generation of cerebellar Purkinje cells from human pluripotent stem cells.2015
- Author(s)
  Muguruma K
- Organizer
  Gordon Research Conference CAG triplet Repeat 2015
- Place of Presentation
  Lucca, Italy
- Year and Date
  2015-05-31
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07089
[Presentation] Self-organization of polarized cerebellar tissue in 3D culture of human pluripotent stem cells.2015
- Author(s)
  Muguruma K
- Organizer
  ISSCR 13th Annual Meeting
- Place of Presentation
  Stockholm, Sweden
- Year and Date
  2015-06-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07089
[Presentation] 多能性幹細胞からの脳発生の再現2013
- Author(s)
  六車　恵子
- Organizer
  （独）国立精神・神経医療研究センター　神経研究所所内セミナー
- Place of Presentation
  東京都小平市　神経研究所
- Year and Date
  2013-03-07
- Invited
- Data Source
  KAKENHI-PUBLICLY-23111535
[Presentation] Ontogeny-recapitulating generation and tissue integration of ES cell-derived Purkinje cells2011
- Author(s)
  六車恵子
- Organizer
  Cortical Development Meeting 2011
- Place of Presentation
  ハニア(ギリシャ、クレタ島)
- Year and Date
  2011-05-21
- Data Source
  KAKENHI-PUBLICLY-23111535
[Presentation] Ontogeny-recapitulating generation and tissue integration of ES cell-derived Purkinje cells2011
- Author(s)
  六車恵子
- Organizer
  Neuroscience 2011 (Society for Neuroscience)
- Place of Presentation
  ワシントンDC(アメリカ)
- Year and Date
  2011-11-15
- Data Source
  KAKENHI-PUBLICLY-23111535
[Presentation] ES細胞からプルキンエ細胞への分化誘導-発生過程の再現と移植の試み-2011
- Author(s)
  六車恵子
- Organizer
  第34回日本神経科学大会
- Place of Presentation
  パシフィコ横浜(横浜市)(招待講演)
- Year and Date
  2011-09-15
- Data Source
  KAKENHI-PUBLICLY-23111535
[Presentation] Ontogeny-recapitulating generation and tissue integration of ES cell-derived Purkinje cells2011
- Author(s)
  六車恵子
- Organizer
  8^<th> IBRO World Congress of Neuroscience
- Place of Presentation
  フィレンツェ(イタリア)
- Year and Date
  2011-07-16
- Data Source
  KAKENHI-PUBLICLY-23111535
[Presentation] Neural induction and self-organization in three-dimensional ES cell culture2011
- Author(s)
  六車恵子
- Organizer
  Key Forum in Developmental Biology and Regenerative Medicine
- Place of Presentation
  熊本大学(熊本市)(招待講演)
- Year and Date
  2011-09-08
- Data Source
  KAKENHI-PUBLICLY-23111535
[Presentation] 多能性幹細胞からの脳発生の再現
- Author(s)
  六車　恵子
- Organizer
  (独）国立精神・神経医療研究センター　神経研究所所内セミナー
- Place of Presentation
  東京都小平市　神経研究所
- Invited
- Data Source
  KAKENHI-PROJECT-24570242
[Presentation] Generation of cerebellar Purkinje cells from human pluripotent stem cells.
- Author(s)
  Muguruma K.
- Organizer
  Gordon Research Conference
- Place of Presentation
  Renaissance Tuscany Il Ciocco Lucca (Barga), Italy
- Year and Date
  2015-05-31 – 2015-06-05
- Data Source
  KAKENHI-PROJECT-24570242
[Presentation] Self-organization of polarized cerebellar tissue in 3D culture of human pluripotent stem cells.
- Author(s)
  Muguruma K.
- Organizer
  ISSCR
- Place of Presentation
  Stockholm, Sweden
- Year and Date
  2015-06-24 – 2015-06-27
- Data Source
  KAKENHI-PROJECT-24570242
[Presentation] ヒト多能性幹細胞の3次元培養による極性を伴った小脳組織の自己組織的な形成
- Author(s)
  六車　恵子
- Organizer
  日本神経科学
- Place of Presentation
  神戸、兵庫県
- Year and Date
  2015-07-28 – 2015-07-31
- Data Source
  KAKENHI-PROJECT-24570242

1. TAMADA Atsushi (60270576)

# of Collaborated Projects: 4 results

# of Collaborated Products: 2 results
2. 川上秀史 (70253060)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
3. 宮本達雄 (40452627)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 久米広大 (20592314)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
5. 倉重毅志 (20710627)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
6. 多田有似 (90881285)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 木村俊哉 (10622186)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. SUGA Hidetaka

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. YOKOKAWA Ryuji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 大磯ユタカ

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 大石明生

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
12. 井口元三

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 手塚裕之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

MUGURUMA Keiko 六車 恵子

Research Projects

Research Products

Co-Researchers

オルガノイドインテリジェンスの構築によるヒト脳機能の解明

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患者iPS細胞を用いたオプティニューリン変異による神経変性機構の解明

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大脳皮質基底核変性症の疾患モデル構築と病態解明

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Identification and analysis of novel genes of amyotrophic lateral screlosis

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Ontogeny-recapitulating generation of human pluripotent stem cell-derived cerebellar organoidsPrincipal Investigator

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Construction and analysis of in vitro brain tissues for elucidation of human brain functions

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Investigation of human brain function with organoid networkPrincipal Investigator

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Analysis and control of singularity structures triggering epileptic seizurePrincipal Investigator

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Development of methods for construction and automated analysis of human brain organoids

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Vulnerability of cerebellar and cerebral cortical neurons in neurodegenerative diseasesPrincipal Investigator

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An analysis of cerebellar histogenesis generated from human pluripotent stem cellsPrincipal Investigator

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Self-organization of cerebellar tissue in 3D culture of human pluripotent stem cellsPrincipal Investigator

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プルキンエ細胞の秩序ある配置のための細胞と場の動的相互作用Principal Investigator

Principal Investigator

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Research Category

MUGURUMA Keiko 六車恵子

[Book] 決定版　オルガノイド実験スタンダード「II-7. 小脳オルガノイドの作製とプルキンエ細胞への誘導, 」2019