MARUYAMA Toshiyuki 丸山稔之

Researcher Number	30219571
Other IDs
Affiliation (based on the past Project Information) *help	2006: The University of Tokyo, Faculty of Medicine, Lecturer, 大学院・医学系研究科, 講師 2006: 東京大学, 大学院医学系研究科, 講師 2005: 東京大学, 医学部附属病院, 講師 2000 – 2004: 東京大学, 大学院・医学系研究科, 講師 2001: 東京大学, 大学院・医学系研究科医学部, 講師 … More 1996 – 1999: 東京大学, 医学部・附属病院, 助手 1997: 東京大学, 医学部附属病院, 助手 1996: Faculty of Med, Dept of Med(2), University of Tokyo, Assistant, 医学部(附属病院), 助手 1995: 東京大学, 医学部・付属病院, 助手 Less
Review Section/Research Field	Principal Investigator Gastroenterology / Gastroenterology Except Principal Investigator Gastroenterology / Gastroenterology
Keywords	Principal Investigator cytokine / mutation / HBV-DNA / transgenic mouse / tolerance / HBV / immune suppression therapy / 免疫応答 / HCV / coagulated volume … More / development of liver tumors / tumor necrosis / microbubble / HIFU / 肝臓癌モデルrat / 経門脈的投与 / 焼灼体積 / 肺臓癌モデルrat / パルミチン酸 / 腫瘍壊死 / マイクロバブル / 強力集束超音波発信装置 / 核酸変異 / 抗原提示 / トランスジェニックマウス / fulminant hepatitis / IFNγ / IL1 / TNFα / 塩基配列 / HBVキャリアー / 免疫抑制剤 / 劇症肝炎 / fulminant hepatits / mouse / prognostic ralue / IgG subtype / interferon / vaccine / peptide / ペプタイト / C型肝炎 / IgGサブクラス / エペトープ / マウス / 治療効果 / IgGサブタイプ / インターフェロン / ワクチン / ペプタイド / 細胞周期 / 肝発癌 / コア蛋白 / C型肝炎ウイルス … More Except Principal Investigator HCV / アンギオスタチン / C型肝炎ウイルス / C型肝炎 / liver cancer / RNA interference / 肝臓癌 / RNA干渉 / receptor / 受容体 / liver endothelial cells / Angiostain / 腫瘍血管 / 肝臓内皮細胞 / viral receptor / hepatitis C virus / レセプター / ウイルスレセプター / coagulation & fibrinolysis / plasminogen / hepatocellular carcinoma / angiostatin / 血液凝固線溶系 / プラスミノーゲン / 肝細胞癌 / DNA vaccine / hepatocarcinogenesis / hepatitis / core protein / envelope protein / transgenic mice / hepatitis C / 唾液腺炎 / シェ-グレン症候群 / DNAワクチン / 肝発癌 / 肝炎 / コア蛋白 / エンベロープ蛋白 / トランスジェニックマウス / Stress protein / Autoantibody / Autoimmune hepatitis / 抗ストレス抗体 / HSP 70 / ELISA法 / ストレス蛋白 / 自己抗体 / 自己免疫性肝炎 Less

Fundamental study for therapy of liver cancers based on RNA interference
- Principal Investigator
  
  MITSUI Hiroshi
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
Using microbubbles to increase the destruction of liver tumors by high-intensity focused ultrasoundPrincipal Investigator
- Principal Investigator
  
  MARUYAMA Toshiyuki
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
Identification and analysis of co-receptor for hepatitis C virus
- Principal Investigator
  
  MITSUI Hiroshi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
The comparison of virus genome and immune reaction between asymptomatic carriers and chronic hepatitis patients infected with HBV.Principal Investigator
- Principal Investigator
  
  MARUYAMA Toshiyuki
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
The study of tumor vessel growth inhibiton Angiostatin, new mechanism of action and clinical application
- Principal Investigator
  
  MITSUI Hiroshi
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
Identification of hepatitis C virus receptor on human hepatocytes and regulation of the viral infection
- Principal Investigator
  
  MITUSI Hiroshi
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
The mechanism which causes fulminant hepatic failure after immune suppression therapy on HBV carrier patientsPrincipal Investigator
- Principal Investigator
  
  MARUYAMA Toshiyuki
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
Characterization of the anti-angiogenic factors in hepatocellular carcinoma10301102
- Principal Investigator
  
  MAEKAWA Hisato
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
Investigation for the development of vaccine against hepatitis C virusPrincipal Investigator
- Principal Investigator
  
  MARUYAMA Toshiyuki
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
肝発癌におけるC型肝炎コア蛋白の遺伝子発現修飾作用とその細胞内結合蛋白の同定Principal Investigator
- Principal Investigator
  
  丸山稔之
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
DEVELOPMENT OF HEPATITIS THERAPY AND VACCINE USING HEPATITIS C VIRUS TRANSGENIC MICE
- Principal Investigator
  
  KOIKE Kazuhiko
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Gastroenterology
- Research Institution
  TOKYO UNIVERSITY
Immunological significance of stress procein in pathogenesis of autoimmune hepatitis
- Principal Investigator
  
  NOSAKA Kazuo
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  University of Tokyo

All 2006 2005 2004 2003 2001 Other

All Journal Article Book

[Book] In Proceedings of 3rd International Symposium on Therapeutic Ultrasound2005
- Author(s)
  Kaneko Y, Maruyama T, et al.
- Publisher
  The effect of microbubbles as a heat transducer.
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390228
[Journal Article] Microbubble-induced increase in ablation of liver tumors by high-intensity focused ultrasound2006
- Author(s)
  Hanajiri K, Maruyama T, Mitsui H, et al.
- Journal Title
  
  Hepatology Research 36
  
  Pages: 308-314
- NAID
  10018639873
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590617
[Journal Article] Use of a microbubble agent to increase the effects of high intensity focused ultrasound on liver tissue.2005
- Author(s)
  Kaneko Y, Maruyama T, Mitsui M, et al.
- Journal Title
  
  European Radiology 14
  
  Pages: 1415-1420
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590617
[Journal Article] 18F-FDG PET for hepatocellular carcinoma presenting with portal vein thrombus.2005
- Author(s)
  Hanajiri K, Mitsui H, Maruyama T, Kondo Y, Shiina S, Omata M, Nakagawa K.
- Journal Title
  
  Journal of Gastroenterology. 40
  
  Pages: 1005-1006
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390228
[Journal Article] Use of a microbubble agent to increase the effects of high intensity focused ultrasound on liver tissue.2005
- Author(s)
  Kaneko Y, Maruyama T, Takegami K, Watanabe T, Mitsui M, Hanajiri K, Nagawa H, Matsumoto Y.
- Journal Title
  
  European Radiology 15
  
  Pages: 1415-1420
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390228
[Journal Article] 18F-FDGPET for hepatocellular carcinoma presenting with portal vein thrombus.2005
- Author(s)
  Hanajiri K, Mitsui H, Maruyama T, Kondo Y, Shiina S, Omata M, Nakagawa K
- Journal Title
  
  Journal of Gastroenterology. 2005.40
  
  Pages: 1005-1006
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390228
[Journal Article] 18F-FDG PET for hepatocellular carcinoma presenting with portal vein tumor thrombus.2005
- Author(s)
  Hanajiri K, Mitsui H, Maruyama T, et al.
- Journal Title
  
  Journal of Gastroenterology 40
  
  Pages: 1005-1006
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590617
[Journal Article] 18F-FDG PET for hepatocellular carcinoma presenting with portal vein tumor thrombus2005
- Author(s)
  Hanajiri K, Mitsui H, Maruyama T, et al.
- Journal Title
  
  J Gastroenterol 40
  
  Pages: 1005-1006
- Data Source
  KAKENHI-PROJECT-17590617
[Journal Article] Comparison of Optison and MRX-133 microbubble contrast agent in improving heating and coagulation volume efficiency of high intensity focused ultrasound.2005
- Author(s)
  Takegami K, Kaneko K, Watanabe T, Maruyama T, Matsumoto Y, Nagawa H.
- Journal Title
  
  Radiology 237
  
  Pages: 132-136
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390228
[Journal Article] Use of a microbubble agent to increase the effects of high intensity focused ultrasound on liver tissue.2005
- Author(s)
  Kaneko Y, Maruyama T, et al.
- Journal Title
  
  European Radiology 15
  
  Pages: 1415-1420
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390228
[Journal Article] Erythrocytes, as well as microbubble contrast agents, are important factors in improving thermal and therapeutic effects of high-intensity focused ultrasound.2005
- Author(s)
  Takegami K, Kaneko K, Watanabe T, Maruyama T, Matsumoto Y, Nagawa H.
- Journal Title
  
  Ultrasound in Medicine and Biology 31
  
  Pages: 385-390
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390228
[Journal Article] Use of a minobuble agent to increase the effect of high in tensity focused ultrasound on liver tissuce.2005
- Author(s)
  Kanaeko Y, Maruyama T, Mitsui H, et al.
- Journal Title
  
  Eur Radiol 92
  
  Pages: 55-62
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590623
[Journal Article] Use of a microbuble agent to increase the effects of high intensity focused ultrasound on time tissue2005
- Author(s)
  Kaneko Y, Maruyama T, … Mitsui H, et al.
- Journal Title
  
  Eur Radiol 92
  
  Pages: 55-62
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590623
[Journal Article] Use of a microbubble agent to increase the effects of high intensity focused ultrasound on liver tissue.2005
- Author(s)
  Kaneko Y, Maruyama T, Mitsui M, et al.
- Journal Title
  
  European Radiology 15
  
  Pages: 1415-1420
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590617
[Journal Article] Use of a microbuble agent to increase the effect of high intensity focused ultrasound on liver tissue.2005
- Author(s)
  Kaneko Y, Maruyama T,... Mitsui H, et al.
- Journal Title
  
  Eur Radiol 92
  
  Pages: 55-62
- Data Source
  KAKENHI-PROJECT-17590617
[Journal Article] Polyacrylamide gel containing egg white as new model for irradiation experiments using focused ultrasound.2004
- Author(s)
  Takegami K, Kaneko K, Watanabe T, Maruyama T, Matsumoto Y, Nagawa H.
- Journal Title
  
  Ultrasound in Medicine and Biology 30
  
  Pages: 1419-1422
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390228
[Journal Article] Clinical efficacy and toxicity of gefitinib in patients with lung cancer2003
- Author(s)
  Mitsui H, … Maruyama T, et al.
- Journal Title
  
  Lancet 361
  
  Pages: 1993-1993
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590623
[Journal Article] Anti-HBS antibodies produced after live transplantation : from the donor or the recipient?2003
- Author(s)
  Maruyama T, Mitsui H, et al.
- Journal Title
  
  Hepatology 38
  
  Pages: 271-272
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590623
[Journal Article] Anti-Hβs antibodies produces after liver transplantation : from the donor or the recipient ?2003
- Author(s)
  Maruyama T, Mitsui H, et al.
- Journal Title
  
  Hepatology 38
  
  Pages: 271-272
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590623
[Journal Article] The effect of microbubbles as a heat transducer.2003
- Author(s)
  Kaneko Y., Higaki T., Maruyama T., Matsumoto Y.
- Journal Title
  
  In Proceedings of 3rd International Symposium on Therapeutic Ultrasound; Lyon, France
  
  Pages: 55-60
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390228
[Journal Article] Clinical efficacy and toxicity of gefitinib in patients with lung cancer.2003
- Author(s)
  Mitsui H, Nakajima J, Maruyama T, Hanajiri K, Omata M.
- Journal Title
  
  Lancet 361
  
  Pages: 1993-1993
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390228
[Journal Article] Clinical efficacy and toxicity of gefitinib in patients with lung cancer2003
- Author(s)
  Mitsui H, Maruyama T, et al.
- Journal Title
  
  Lancet 361
  
  Pages: 1993-1993
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590623
[Journal Article] Anti-HBs antibodies produced after liver transplantation : from the donor or the recipient?2003
- Author(s)
  Maruyama T., Mitsui H., Hanajir Ki, Sugawara Y, Imamura H, Makuuchi M.
- Journal Title
  
  Hepatology 38
  
  Pages: 271-272
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390228
[Journal Article] Anti-HBs antibodies produced after liver transplantation : from the donor or the recipient?2003
- Author(s)
  Maruyama T, et al.
- Journal Title
  
  Hepatology 38
  
  Pages: 271-72
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390228
[Journal Article] IgGi anti-P2 as a marker of response to interferon in patients with chronic hepatitis C.2001
- Author(s)
  Hirayama M, Maruyama T, Mitsui H, Maekawa H, Yamada H, Hashimoto N, Koike K, Kimura S, Yasuda K, Iino S, Green J.
- Journal Title
  
  Clin Exp Immunol. 126(1)
  
  Pages: 92-100
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13670496
[Journal Article] The MEK1-ERK map kinase pathway and the PI 3-kinase-Akt pathway independently mediate anti-apoptotic signals in HepG2 liver cancer cells.2001
- Author(s)
  Mitsui H, Takuwa N, Maruyama T, Maekawa H, Hirayama M, Sawatari T, Hashimoto N, Takuwa Y, Kimura S.
- Journal Title
  
  Int J Cancer. 92(1)
  
  Pages: 55-62
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13670496
[Journal Article] Esophageal smooth muscle tumor in a 25-year-old woman with congenital malformations.2001
- Author(s)
  Maekawa H, Tanaka N, Hashimoto N, Yamada H, Mitsui H, Ikeda H, Maruyama T, Mori M, Nagawa H, Kimura S.
- Journal Title
  
  J Gastroenterol. 36(10)
  
  Pages: 700-703
- NAID
  50000970489
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13670496
[Journal Article] Use of a microbulluasent to increare the effects of high intensity tocured ultrasound on liver tissue
- Author(s)
  Kaneko Y, Maruyama T, Mitsui H, et al.
- Journal Title
  
  European Ladiology (in press)
- Data Source
  KAKENHI-PROJECT-15590623

1. MITSUI Hiroshi (30239280)

# of Collaborated Projects: 8 results

# of Collaborated Products: 16 results
2. KOIKE Kazuhiko (80240703)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
3. MAEKAWA Hisato (10301102)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. MORIYA Kyouji (00272550)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. SAKATA Youichi (40129028)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. YOTSUYANAGI Hiroshi (30251234)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. NOSAKA Kazuo (70150274)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. YAMADA Haruki (70174729)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. TSUKAMOTO Kazuhisa (20251233)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. TOMA Shigeto (50207528)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. AOKI Katsunori (40291322)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. MATSUMOTO Yoichiro (60111473)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
13. TAKAGI Shu (30272371)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. NANGAKU Masaomi (90311620)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. ISHIBASHI Kotaro

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. SHINTANI Yoshizumi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. UMEMURA Shinichiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 温活寛

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. HAN Kk

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 潘活寛

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

MARUYAMA Toshiyuki 丸山 稔之

Research Projects

Research Products

Co-Researchers

Fundamental study for therapy of liver cancers based on RNA interference

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Using microbubbles to increase the destruction of liver tumors by high-intensity focused ultrasoundPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification and analysis of co-receptor for hepatitis C virus

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The comparison of virus genome and immune reaction between asymptomatic carriers and chronic hepatitis patients infected with HBV.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The study of tumor vessel growth inhibiton Angiostatin, new mechanism of action and clinical application

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of hepatitis C virus receptor on human hepatocytes and regulation of the viral infection

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The mechanism which causes fulminant hepatic failure after immune suppression therapy on HBV carrier patientsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Characterization of the anti-angiogenic factors in hepatocellular carcinoma10301102

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation for the development of vaccine against hepatitis C virusPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

肝発癌におけるC型肝炎コア蛋白の遺伝子発現修飾作用とその細胞内結合蛋白の同定Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

DEVELOPMENT OF HEPATITIS THERAPY AND VACCINE USING HEPATITIS C VIRUS TRANSGENIC MICE

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Immunological significance of stress procein in pathogenesis of autoimmune hepatitis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] In Proceedings of 3rd International Symposium on Therapeutic Ultrasound2005

Author(s)

Publisher

Description

MARUYAMA Toshiyuki 丸山稔之