KITAJIMA Yoshihiko 北島吉彦

Researcher Number	30234256
External Links
Affiliation (Current)	2022: 佐賀大学, 医学部, 客員研究員
Affiliation (based on the past Project Information) *help	2013 – 2020: 佐賀大学, 医学部, 客員研究員 2015: 佐賀大学, 医学部, その他 2013 – 2015: 佐賀大学, 医学部, 研究員 2014: 佐賀大学, 医学部医学科, 助教 2010: Saga University, 医学部, 客員研究員 2003 – 2009: Saga University, Faculty of Medicine, Lecturer, 医学部, 講師 1997 – 2002: 佐賀医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Digestive surgery / Basic Section 55020:Digestive surgery-related Except Principal Investigator Digestive surgery / Digestive surgery / Clinical nursing / General surgery
Keywords	Principal Investigator アポトーシス / 胃癌 / 活性酸素 / 低酸素環境 / HIF-1 / 膵癌 / 胆嚢癌 / ジェムシタビン / MMKY-01 / RRM1 … More Except Principal Investigator MGMT / hMLH1 / 胃癌 / CHFR / 消化器癌 / HIF-1α / DNAメチル化 / 胆嚢癌 / メチル化 / 腹膜播種 / 低酸素 / リンパ管新生 / 低酸素環境 / Morphogenesis / E-cadherin / α-catenin / Proliferation / Differentiation / 胆道癌 / Hypermethylation / DPD / 血清 / 抗癌剤感受性 / Methylight / メチル化プロモーターアレイ / 胆汁 / 早期診断 / DNAメチル化プロファイル / メチル化アレイ / 切除可能食道癌 / T2T3食道癌 / 食道切除 / 根治的化学放射線療法 / インフォームド・コンセント / 前向き臨床試験 / 多施設研究 / 中等度進行食道癌 / 多施設共同研究 / エピゲノム / スキルス胃癌 / ANGPTL4 / アノイキス / 細胞周期 / 低酸素誘導因子 / LOXL2 / HIF-1a / ANGPTNL4 / Epithclial Cells / Gallbladder cncer / Collagen gel culnre / 形態調節 / 分化度 / extracellular matrix / 胆嚢癌株細胞 / 増殖因子 / 形態形成 / 接着因子 / Epithelial Cells / Gallbladder cancer / Collagen gel culture / 胃切除 / 骨代謝障害 / 骨密度 / 身体活動 / 食生活 / 超音波法 / 骨密度測定 / 骨量測定 / gastrectomy / bone metabolism / bone cell density / physical activity / dietary life / ultrasound densitometer / 肝細胞癌 / GC-AT transiton / 予後予測 / hMSH2 / 慢性拒絶反応 / 大動脈移植 / 動脈硬化 / 虚血再灌流傷害 / 阻血時間 / chronic rejection / aortic transplantation / arteriosclerosis / ischemia-reperfusion injury / DNA修復遺伝子 / アルキル化抗癌剤 / 個別化治療 / 遺伝子メチル化 / 感受性マーカー / hMLHl / CDDP / 遺伝子変異 / DNA repair gene / Alkylating agents / Gastrointestinal cancer / Selective chemotherapy / マイトファジー / ROS / 活性酸素 / 脂肪酸合成 / YC-1 / パルミチン酸 / カルニチン / 癌 / Warburg効果 / 脂肪酸代謝 Less

Impaired hypoxia-induced mitochondrial sleep may increase malignant behavior of gastric cancer cellsPrincipal Investigator
- Principal Investigator
  
  Kitajima Yoshihiko
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Saga University
Basic research of novel therapeutic strategy focusing on fatty acid metabolism alteration of gastric cancer cells under hypoxia
- Principal Investigator
  
  Noshiro Hirokazu
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Saga University
A novel mechanism increasing gastric cancer aggressiveness via impaired mitophagy
- Principal Investigator
  
  Nakamura Jun
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Saga University
Establishment of novel drug therapy targetting Warburg effect in gastric cancerPrincipal Investigator
- Principal Investigator
  
  Kitajima Yoshihiko
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Saga University
Investigation of peritoneal dissemination mechanism through trans-vessel route in scirrhous gastric cancer
- Principal Investigator
  
  Ikeda Osamu
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Saga University
Molecular target therapy induced by hypoxia for scirrhous gastric cancer.
- Principal Investigator
  
  KOGA Yasuo
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Saga University
Basic analysis of anti-allergic agent MMKY-01, which accelerating drug sensitivity to gemicitabine in pancreatic cancer cell.Principal Investigator
- Principal Investigator
  
  KITAJIMA Yoshihiko
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Saga University
Prospective non-randomized trial comparing esophagectomy versus definitive chemoradiation for potentially-resectable esophageal cancer : multi-institutional study
- Principal Investigator
  
  FUJITA Hiromasa, 藤田博正
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Kurume University
胆汁中DNAメチル化プロファイルによる早期胆嚢癌診断法の開発
- Principal Investigator
  
  宮崎耕治
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Digestive surgery
- Research Institution
  Saga University
個別化治療のためのDNA修復遺伝子メチル化を分子マーカーとした血清診断法の構築
- Principal Investigator
  
  MIYAZAKI Kohji
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Digestive surgery
- Research Institution
  Saga University
Nobel therapeutic strategy based on deficient expression of DNA repair gene in gastrointestinal cancers.
- Principal Investigator
  
  MIYAZAKI Kohji
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Saga University
  佐賀医科大学
Analysis of mechanisms and development of inhibition methods for chronic resection
- Principal Investigator
  
  NAKAFUSA Yuji
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Saga University
Role of DNA repair gene MGMT, hMLHI and hMSH2 in oncogenesis and progression of human gastrointestinal, hepatobiliary carcinoma
- Principal Investigator
  
  MIYAZAKI Kohji
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Saga Medical School
A health program to prevent a patient who received a gastrectomy from bone metabolism disorder
- Principal Investigator
  
  KAWAMOTO Rieko, 橋本惠美子 (橋本恵美子)
- Project Period (FY)
  1999 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Clinical nursing
- Research Institution
  University of Occupational and Environmental Health
  佐賀医科大学
Factors affecting morphogenesis of normal gallbladder epithelial cells and those regulationg differentiation in gallbladder cancer cells.
- Principal Investigator
  
  MIYAZAKI Kohji
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Saga Medical School

All 2019 2017 2016 2015 2013 2010 2009 2008 2007 2006 Other

All Journal Article Presentation

[Journal Article] Mieap-induced accumulation of lysosomes within mitochondria (MALM) regulates gastric cancer2019
- Author(s)
  Okuyama Keiichiro、Kitajima Yoshihiko、Egawa Noriyuki、Kitagawa Hiroshi、Ito Kotaro、Aishima
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Pages: 1-13
- DOI
  10.1038/s41598-019-39563-x
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08650
[Journal Article] Hypoxia-induced ANGPTL4 sustains tumour growth and anoikis resistance through different mechanisms in scirrhous gastric cancer cell lines.2017
- Author(s)
  Baba K, Kitajima Y, Miyake S, Nakamura J, Wakiyama K, Sato H, Okuyama K, Kitagawa H, Tanaka T, Hiraki M, Yanagihara K, Noshiro H.
- Journal Title
  
  Sci Rep.
  
  Volume: 7 Pages: 11127-11127
- DOI
  10.1038/s41598-017-11769-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K10103
[Journal Article] Low-dose YC-1 combined with glucose and insulin selectively induces apoptosis in hypoxic gastric carcinoma cells by inhibiting anaerobic glycolysis.2017
- Author(s)
  Wakiyama K, Kitajima Y, Tanaka T, Kaneki M, Yanagihara K, Aishima S, Nakamura J, Noshiro H.
- Journal Title
  
  Sci Rep.
  
  Volume: 7 Pages: 12653-12653
- DOI
  10.1038/s41598-017-12929-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K10103
[Journal Article] Regulation and clinical significance of the hypoxia-induced expression of ANGPTL4 in gastric cancer.2016
- Author(s)
  Kubo H, Kitajima Y, Kai K, Nakamura J, Miyake S, Yanagihara K, Morito K, Tanaka T, Shida M, Noshiro H
- Journal Title
  
  Oncol Lett.
  
  Volume: 11 Pages: 1026-1034
- DOI
  10.3892/ol.2015.4011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K10103
[Journal Article] Impaired mitophagy activates mtROS/HIF-1α interplay and increases cancer aggressiveness in gastric cancer cells under hypoxia2016
- Author(s)
  Shida M, Kitajima Y, Nakamura J, Yanagihara K, Baba K, Wakiyama K, Noshiro H.
- Journal Title
  
  Int J Oncol
  
  Volume: 48 Pages: 1379-90
- DOI
  10.3892/ijo.2016.3359
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K10103
[Journal Article] The apoptotic effect of HIF-1α inhibition combined with glucose plus insulin treatment on gastric cancer under hypoxic conditions2015
- Author(s)
  Tanaka T, Kitajima Y, Miyake S et al
- Journal Title
  
  PLoS One
  
  Volume: 10
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25462025
[Journal Article] HIF-1a is a crucial factor in the development of peritoneal dissemination via natural metastatic rouites in scirrhous gastric cancer2013
- Author(s)
  Miyake S, Kitajima Y, Nakamura J, Kai K, Yanagihara K et al
- Journal Title
  
  Int J Oncol
  
  Volume: 43 Pages: 1431-1440
- DOI
  10.3892/ijo.2013.2068
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25462025, KAKENHI-PROJECT-25462026
[Journal Article] Tranilast strongly sensitizes pancreatic cancer cells to gemcitabine via decreasing protein expression of ribonucleotide reductase 12010
- Author(s)
  M Mituno, Y Kitajima, at al
- Journal Title
  
  International Journal of Oncology 36
  
  Pages: 341-349
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591632
[Journal Article] Ribonucleotide reductase subunit M1 assessed by quantitative double-fluorescence immunohistochemistory predicts the efficacy of gemcitabine in biliary tract carcinoma.2010
- Author(s)
  Nakamura J, Kohya N, Kai K, Ohtaka K, Hashiguchi K, Hiraki M, Kitajima Y, Tokunaga O, Noshiro H, Miyazaki K.
- Journal Title
  
  Int J Oncol 37
  
  Pages: 845-852
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591632
[Journal Article] Tranilast strongly sensitizes pancreatic cancer cells to gemcitabine via decreasing protein expression of ribonucleotide reductase 1.2010
- Author(s)
  Mayumi Mitsuno, Yoshihiko Kitajima, Kazuma Ohtaka, Keita Kai, Kazuyoshi Hashiguchi, Jun Nakamura, Masatsugu Hiraki, Hirokazu Noshiro, Kohji Miyazaki.
- Journal Title
  
  Int J Oncol 36
  
  Pages: 341-349
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591632
[Journal Article] False positive fingings for tumor markers after curative gastrectomy for gastric cancer2008
- Author(s)
  Ohtsuka T, Sato S, Kitajima Y, Tanaka M, Nakafusa Y, Miyazaki K
- Journal Title
  
  Dig Dis Sci 53
  
  Pages: 73-79
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18659388
[Journal Article] Quantitative double fluorescence immunohistochemistry (qDFIHC), a novel technology to assess protein expression : A pilot study analyzing 5-FU sensitive markers tymidylate synthase, dihydropyrimidine, and orotate phosphoribosyl transferase in gastric canc2007
- Author(s)
  Kai K, Kitajima Y, Hiraki M, Satoh S, Tanaka M, Nakafusa Y, Tokunaga O, Miyazaki K
- Journal Title
  
  Cancer Letters 258
  
  Pages: 45-54
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18659388
[Journal Article] The hypoxic enviroment in tumor-stromal cells accelerates pancreatic cancer progression via the activation of paracrine hepatocyte growth factor/c-Met signaling2007
- Author(s)
  Ide T, Kitajima Y, Miyoshi A, Ohtsuka T, Mitsuno M, Ohtaka K, Miyazaki K
- Journal Title
  
  Ann Surg Oncol 14(9)
  
  Pages: 2600-2607
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18659388
[Journal Article] Helicobacter pylori infection is an independent risk factor for Runx3 methylation in gastric cancer2007
- Author(s)
  Kitajima Y, Ohtaka K, Mitsuno M, Tanaka M, Sato S, Nakafusa Y, Miyazaki K
- Journal Title
  
  Oncol Rep 19
  
  Pages: 197-202
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18659388
[Journal Article] CPT-11(SN-38)chemotherapy may be selectively applicable to biliary tract cancer with low hMLH1 expression2007
- Author(s)
  Sato K, Kitajima Y, Kohya N, Koga Y, Ohtaka K, Miyazaki K
- Journal Title
  
  Anticancer Res. 27
  
  Pages: 865-872
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18659388
[Journal Article] Aberrant methylation of p16 predicts the candidates for 5-fluorouracil based adjuvant chemotherapy in gastric cancer patients2007
- Author(s)
  Mitsuno M, Kitajima Y, Ide T, Ohtaka K, Tanaka M, Sato S, K Miyazaki
- Journal Title
  
  J Gastroenterol 42
  
  Pages: 866-873
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18659388
[Journal Article] Tumor-stromal interaction under hypoxia increases invasiveness of pancreas cancer cells through HGF-c-Met pathway2006
- Author(s)
  Ide T, Kitajima Y, Miyoshi A, Ohtsuka T, Mitsuno M, Ohtaka K, Koga Y, Miyazaki K
- Journal Title
  
  Int J Cancer 119
  
  Pages: 2750-2759
- Data Source
  KAKENHI-PROJECT-18659388
[Journal Article] Deficient expression of DPD gene is caused by epigenetic modification in biliary tract cancer cell and showed high sensitivity to 5-FU treatment2006
- Author(s)
  Sato K, Kitajima Y, Miyoshi A, Koga Y, Miyazaki K
- Journal Title
  
  Int J Oncol 29 (2)
  
  Pages: 429-435
- Data Source
  KAKENHI-PROJECT-18659388
[Journal Article] Hypoxia accelerates cancer invasion of hepatoma cells by upregulating MMP expression in HIF-1α-independent manner.2006
- Author(s)
  Miyoshi A, Kitajima Y, IdeT, Ohtaka K, Nagasawa H, Uto Y, Hori H, Miyazaki K
- Journal Title
  
  Int J Oncol 29
  
  Pages: 1533-1539
- Data Source
  KAKENHI-PROJECT-18659388
[Journal Article] The significance of aberrant CHFR methylation for clinical response to microtubule inhibitors in gastric cancer.2006
- Author(s)
  Koga Y, Kitajima Miyoshi A, Sato K, Sato S, Miyazaki K
- Journal Title
  
  J Gastroenterol 41
  
  Pages: 133-139
- NAID
  10017421128
- Data Source
  KAKENHI-PROJECT-18659388
[Journal Article] Aberrant promoter hypermethylation in biliary tract cancinoma.2006
- Author(s)
  Kohya N, Koga Y, Kitajima, Miyazaki K
- Journal Title
  
  J Hepatobiliary Pancreat Surg 13
  
  Pages: 296-305
- Data Source
  KAKENHI-PROJECT-18659388
[Journal Article] Methylation-induced silencing of ASC and effect of expressed ASC on p53-mediated chemosensitivity in colorectal cancer.2006
- Author(s)
  Ohtsuka T, Xiao-Fang Liu, Koga Y, Kitajima Y, Nakafusa Y, Sam W Lee, Miyazaki K
- Journal Title
  
  Oncogene 25 25
  
  Pages: 1807-1811
- Data Source
  KAKENHI-PROJECT-18659388
[Presentation] Warburg効果をターゲットとした胃癌に対する新規薬物療法：HIF1α阻害剤YC-1+GI療法の機序解析と臨床応用への可能性2017
- Author(s)
  脇山幸大、北島吉彦、田中智和、金木正夫、中村淳、柳原五吉、能城浩和
- Organizer
  日本外科学定期学術集会
- Data Source
  KAKENHI-PROJECT-15K10103
[Presentation] 腫瘍内8OHdGは進行大腸癌における予後予測因子となりうる2017
- Author(s)
  北川浩、北島吉彦、中村淳、田中智和、古賀靖大、真鍋達也、能城浩和
- Organizer
  日本癌学会
- Data Source
  KAKENHI-PROJECT-15K10103
[Presentation] Mieap発現欠失による低酸素環境下ミトコンドリア品質管理機構の破綻と胃癌悪性度増強機序2017
- Author(s)
  奥山桂一郎、北島吉彦、田中智和、中村淳、北川浩、江川紀幸、柳原五吉、中村康之、荒川博文、能城浩和
- Organizer
  日本癌学会
- Data Source
  KAKENHI-PROJECT-15K10103
[Presentation] Mieap発現欠失による低酸素環境下ミトコンドリア品質管理機構の破綻と胃癌悪性度増強機序2017
- Author(s)
  奥山桂一郎、北島吉彦、田中智和、志田雅明、馬場耕一、脇山幸大、佐藤博文、北川　浩、中村　淳、能城浩和
- Organizer
  第117回日本外科学会定期学術集会
- Place of Presentation
  横浜
- Year and Date
  2017-04-27
- Data Source
  KAKENHI-PROJECT-15K10103
[Presentation] 低用量YC-1+GI療法によるWarburg効果をターゲットとした胃癌に対する新規薬物療法2017
- Author(s)
  脇山幸大、北島吉彦、田中智和、金木正夫、柳原五吉、相島慎一、中村淳、能城浩和
- Organizer
  日本癌学会
- Data Source
  KAKENHI-PROJECT-15K10103
[Presentation] Mieap発現欠失による低酸素環境下ミトコンドリア品質管理機構の破綻と胃癌悪性度増強機序2017
- Author(s)
  奥山桂一郎、北島吉彦、田中智和、志田雅明、馬場耕一、脇山幸大、佐藤博文、北川　浩、中村　淳、能城浩和
- Organizer
  日本外科学定期学術集会
- Data Source
  KAKENHI-PROJECT-15K10103
[Presentation] 低酸素誘導性マイトファジーの破綻介したスキルス胃癌細胞の高悪性性度獲得機序についての新知見2016
- Author(s)
  志田雅明、北島吉彦、中村淳、馬塲耕一、脇山幸大
- Organizer
  第116回日本外科学会定期学術集会
- Place of Presentation
  大阪
- Year and Date
  2016-04-14
- Data Source
  KAKENHI-PROJECT-15K10103
[Presentation] 低酸素環境下でマイトファジーは胃癌細胞の細胞増殖と浸潤能に寄与する2016
- Author(s)
  奥山佳一郎、北島吉彦、志田雅明、中村淳、脇山幸大、佐藤博文、馬塲耕一、柳原五吉、能城浩和
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-15K10103
[Presentation] 低酸素誘導性マイトファジーの破綻を介したスキルス胃癌細胞の高悪性度獲得機序についての新知見2016
- Author(s)
  志田雅明、北島吉彦、能城浩和
- Organizer
  第71回日本消化器外科学会総会
- Place of Presentation
  徳島
- Year and Date
  2016-07-14
- Data Source
  KAKENHI-PROJECT-15K10103
[Presentation] マイトファジー機構の破綻により、胃癌細胞株の悪性度は増強する2015
- Author(s)
  志田雅明、北島吉彦、中村淳、柳原五吉、能城浩和
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-15K10103
[Presentation] ANGPTL4とLOXL2はスキルス胃癌腹膜播種に関わる遺伝子の可能性がある2015
- Author(s)
  馬場耕一、北島吉彦、三宅修輔　他
- Organizer
  第115回日本外科学会定期学術集会
- Place of Presentation
  名古屋
- Year and Date
  2015-04-16
- Data Source
  KAKENHI-PROJECT-25462026
[Presentation] ANGPTL4は低酸素環境下のスキルス胃癌細胞にアノイキス耐性を誘導し、腹膜播種転移形成を促進する2015
- Author(s)
  馬場耕一、北島吉彦、三宅修輔　他
- Organizer
  第3回がんと代謝研究会
- Place of Presentation
  金沢
- Year and Date
  2015-07-16
- Data Source
  KAKENHI-PROJECT-25462026
[Presentation] マイトファジー機構の破綻により，ROS HIF 1α 経路が活性化され，胃癌浸潤能が増強される2015
- Author(s)
  志田雅明、北島吉彦、中村淳、柳原五吉、能城浩和
- Organizer
  第115回日本外科学会定期学術集会
- Place of Presentation
  名古屋
- Year and Date
  2015-04-16
- Data Source
  KAKENHI-PROJECT-15K10103
[Presentation] 低酸素誘導性マイトファジーの破綻を介したスキルス胃癌細胞の高悪性度獲得機序についての新知見2015
- Author(s)
  志田雅明、北島吉彦、中村淳、柳原五吉、能城浩和
- Organizer
  第3回がんと代謝研究会
- Place of Presentation
  金沢
- Year and Date
  2015-07-16
- Data Source
  KAKENHI-PROJECT-15K10103
[Presentation] 固形癌の低酸素環境下エネルギー代謝変容に着眼したHIF-1α阻害剤＋GI療法の機序解析と臨床応用への可能性2015
- Author(s)
  脇山幸大、北島吉彦、三宅修輔　他
- Organizer
  第3回がんと代謝研究会
- Place of Presentation
  金沢
- Year and Date
  2015-07-16
- Data Source
  KAKENHI-PROJECT-25462025
[Presentation] HIF-1αと癌エネルギー代謝変容に着眼した新規胃癌治療の可能性2015
- Author(s)
  脇山幸大、北島吉彦、田中智和　他
- Organizer
  第115回日本外科学会定期学術集会
- Place of Presentation
  名古屋
- Year and Date
  2015-04-16
- Data Source
  KAKENHI-PROJECT-25462025
[Presentation] スキルス胃癌の腹膜播種はHIF-1あにより活性化されるリンパ管新生を介した遠隔転移である2013
- Author(s)
  三宅修輔、北島吉彦、中村　淳、柳原五吉、田中智和、馬場耕一　他
- Organizer
  第24回日本消化器癌発生学会
- Place of Presentation
  石川県立音楽堂
- Data Source
  KAKENHI-PROJECT-25462025
[Presentation] スキルス胃癌の腹膜播種はHIF-1aにより活性化されるリンパ管新生を介した遠隔転移である。2013
- Author(s)
  三宅修輔、北島吉彦、中村　淳、柳原五吉、田中智和　他
- Organizer
  第24回日本消化器癌発生学会総会
- Place of Presentation
  石川県立音楽堂
- Data Source
  KAKENHI-PROJECT-25462026
[Presentation] Warburg効果をターゲットとした新たな胃癌薬物治療の可能性2013
- Author(s)
  田中智和、北島吉彦、三宅修輔、柳原五吉、馬場耕一、志田雅明　他
- Organizer
  第24回日本消化器癌発生学会
- Place of Presentation
  石川県立音楽堂
- Data Source
  KAKENHI-PROJECT-25462025
[Presentation] Gemcitabine耐性胆道癌細胞株におけるTranilastのApoptosis誘導作用の検討2009
- Author(s)
  橋口和義、北島吉彦、平木将紹、中村淳、能城浩和、宮崎耕治
- Organizer
  第20回日本消化器癌発生学会総会
- Place of Presentation
  オリエンタルホテル広島
- Data Source
  KAKENHI-PROJECT-20591632
[Presentation] GEM耐性胆道癌細胞株におけるTranilastのapoptosis誘導作用の検討2009
- Author(s)
  橋口和義、北島吉彦, 他
- Organizer
  日本消化器癌発生学会
- Place of Presentation
  オリエンタルホテル広島
- Year and Date
  2009-11-27
- Data Source
  KAKENHI-PROJECT-20591632
[Presentation] Gemcitabine耐性胆道癌細胞株におけるTranilastのApoptosis誘導機構についての検討2009
- Author(s)
  橋口和義、北島吉彦、平木将紹、中村淳、光野真由美、宮崎耕治
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-20591632
[Presentation] 胆道癌細胞株におけるTranilastのRRM1発現抑制効果を介したGemcitabine感受性増強作用2008
- Author(s)
  橋口和義、光野真由美、北島吉彦、大高和真、平木将紹、中村淳、神谷尚彦、中房祐司、宮崎耕治
- Organizer
  第108回日本外科学会定期学術集会
- Place of Presentation
  長崎ブリックホール
- Data Source
  KAKENHI-PROJECT-20591632
[Presentation] Tranilast increased the drug effect of gemcitabine via protain degradation of RRM1 in pancreatic cancer cells.2008
- Author(s)
  Yoshihiko Kitajima, Mayumi Mitsuno, Kazuyoshi Hashiguchi, Jun Nakamnura, Masatsugu Hiraki, Kohji Miyazaki
- Organizer
  AACR annual meeting 2008
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-20591632
[Presentation] 膵癌におけるTranilastのRRM1発現抑制効果に基づいたTranilast+Gemcitabine(dFdC)併用療法の可能性2008
- Author(s)
  北島吉彦、光野真由美、橋口和義、中村淳、平木将紹、大塚隆生、神谷尚彦、宮崎耕治
- Organizer
  第19回日本消化器癌発生学会
- Place of Presentation
  別府亀の井ホテル
- Data Source
  KAKENHI-PROJECT-20591632
[Presentation] 膵癌に対するRRM1を分子標的としたTranilast+Gemcitabine併用療法の可能性2008
- Author(s)
  光野真由美、北島吉彦、平木将紹、橋口和義、中村淳、神谷尚彦、宮崎耕治
- Organizer
  第108回日本外科学会定期学術集会
- Place of Presentation
  長崎ブリックホール
- Data Source
  KAKENHI-PROJECT-20591632
[Presentation] 膵癌に対するRRM1を分子標的としたTranilast+GEM併用療法の可能性2008
- Author(s)
  光野真由美, 北島吉彦, 他
- Organizer
  日本外科学会総会
- Place of Presentation
  長崎ブリックホール(長崎)
- Year and Date
  2008-05-15
- Data Source
  KAKENHI-PROJECT-20591632
[Presentation] 胆道癌細胞株におけるイニマチブを用いた分子標的治療の可能性2007
- Author(s)
  中村淳, 北島吉彦, 平木将紹, 橋口和義, 光野真由美, 神谷尚彦, 宮崎耕治
- Organizer
  第18回日本消化器癌発生学会総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-18659388
[Presentation] 胆道癌細胞株を用いたGemcitabineに対する感受性マーカーの検討2007
- Author(s)
  中村淳, 神谷尚彦, 橋口和義, 光野真由美, 大高和真, 北島吉彦, 宮崎耕治
- Organizer
  第49回日本消化器病学会大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-18659388
[Presentation] ANGPTL4とLOXL2はスキルス胃癌腹膜転移の発生における候補遺伝子の可能性がある
- Author(s)
  馬塲耕一、北島吉彦、三宅修輔、中村淳、柳原五吉、田中智和、池田貯、能城浩和
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-24591947
[Presentation] ANGPTL4とLOXL2はスキルス胃癌における腹膜転移の候補遺伝子の可能性がある
- Author(s)
  馬塲耕一、北島吉彦、三宅修輔、中村淳、柳原吾吉、田中智和、志田雅明、脇山幸大、池田貯、能城浩和
- Organizer
  第25回日本消化器癌発生学会総会
- Place of Presentation
  福岡
- Year and Date
  2014-11-13 – 2014-11-14
- Data Source
  KAKENHI-PROJECT-24591947
[Presentation] スキルス胃癌の腹膜播種はHIF-1αにより増強されるリンパ管を介した遠隔転移である
- Author(s)
  三宅修輔、北島吉彦、中村淳、甲斐敬太、柳原五吉、田中智和、馬塲耕一、宮﨑耕治、能城浩和、井手貴雄、古賀靖大、宮﨑耕治、能城浩和
- Organizer
  第114回日本外科学会定期学術集会
- Place of Presentation
  京都
- Year and Date
  2014-04-03 – 2014-04-05
- Data Source
  KAKENHI-PROJECT-24591947
[Presentation] 低酸素環境下のエネルギー代謝変容に着眼した新たな胃癌薬物治療の可能性
- Author(s)
  北島吉彦、田中智和、三宅修輔、中村　淳、宮崎耕治、能城浩和
- Organizer
  第２回がんと代謝研究会
- Place of Presentation
  東京理科大葛飾キャンパス
- Year and Date
  2014-07-10 – 2014-07-11
- Data Source
  KAKENHI-PROJECT-25462025
[Presentation] ANGPTL4とLOXL2はスキルス胃癌腹膜転移の発生における候補遺伝子である
- Author(s)
  馬場耕一、北島吉彦、三宅修輔、中村　淳、柳原五吉、池田　貯　他
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-25462026
[Presentation] HIF-1a発現阻害＋GI療法は胃癌に対する理想的薬物治療となりうる
- Author(s)
  脇山幸大、北島吉彦、田中智和、三宅修輔、西島亜紀、柳原五吉他
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-25462025

1. MIYAZAKI Kohji (30159173)

# of Collaborated Projects: 5 results

# of Collaborated Products: 14 results
2. NAKAMURA Jun (60404175)

# of Collaborated Projects: 5 results

# of Collaborated Products: 23 results
3. KAWAMOTO Rieko (40144969)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. KITAHARA Kenji (30264162)

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5. SATO Seiji (00225955)

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11. HAYABUCHI Naofumi (20108731)

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13. NATSUKOE Shoji (70237577)

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14. HIRAKI Yoshiyuki (90264423)

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16. HAYASHI Nobuyuki (90218587)

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17. KAWAHARA Katsunobu (80152990)

# of Collaborated Projects: 1 results

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18. MATSUMOTO Akira (50336260)

# of Collaborated Projects: 1 results

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19. BABA Hideo (20240905)

# of Collaborated Projects: 1 results

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20. OHYA Natsuo (70281095)

# of Collaborated Projects: 1 results

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21. YAMASHITA Yuichi (50182506)

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22. YOSHIMITSU Kengo (20274467)

# of Collaborated Projects: 1 results

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23. TOKUMARU Sunao (90304899)

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24. NISHIMAKI Tadashi (70242427)

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25. MURAYAMA Sadayuki (60239548)

# of Collaborated Projects: 1 results

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26. MAEHARA Yoshihiko (80165662)

# of Collaborated Projects: 1 results

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27. HONNDA Hiroshi (90145433)

# of Collaborated Projects: 1 results

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28. TANAKA Fumiaki (30332836)

# of Collaborated Projects: 1 results

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29. MIYASAKA Mitsutoshi (10457434)

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30. NAKAMURA Katsumasa (20284507)

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31. SHIRAKUSA Takayuki (20038863)

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32. KOGA Yasuo (30555090)

# of Collaborated Projects: 1 results

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33. MIYAKE Shusuke (70726893)

# of Collaborated Projects: 1 results

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34. Ikeda Osamu (70523124)

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35. MORI Michito (20264161)

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36. MURASE Chiharu (10239519)

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37. ITOU Hideaki (90038852)

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38. KURODA Yusuke (30131915)

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39. TSURUDOME Yousuke (30352305)

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40. NAKAFUSA Yuji (80253417)

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45. 濱本隆浩 (80304905)

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46. TOU Yasushi

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47. SASAKI Tomonari

# of Collaborated Projects: 1 results

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48. NOZOE Tadahiro

# of Collaborated Projects: 1 results

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49. HURUYA Osamu

# of Collaborated Projects: 1 results

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50. HARA Shinsuke

# of Collaborated Projects: 1 results

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51. MUTSUKURA Masahide

# of Collaborated Projects: 1 results

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52. IKEJIRI Kouji

# of Collaborated Projects: 1 results

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53. UEHARA Satoru

# of Collaborated Projects: 1 results

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54. KITAMURA Masayuki

# of Collaborated Projects: 1 results

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55. MATSUMURA Taisei

# of Collaborated Projects: 1 results

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56. MATSUURA Hiroshi

# of Collaborated Projects: 1 results

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57. TOBA Takashi

# of Collaborated Projects: 1 results

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58. MIYAZAKI Mitsuhiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
59. WADA Susumu

# of Collaborated Projects: 1 results

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60. WATANABE Tetsuo

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

KITAJIMA Yoshihiko 北島 吉彦

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Impaired hypoxia-induced mitochondrial sleep may increase malignant behavior of gastric cancer cellsPrincipal Investigator

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Establishment of novel drug therapy targetting Warburg effect in gastric cancerPrincipal Investigator

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Basic analysis of anti-allergic agent MMKY-01, which accelerating drug sensitivity to gemicitabine in pancreatic cancer cell.Principal Investigator

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KITAJIMA Yoshihiko 北島吉彦