• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

HAYASHI Tetsuya  林 哲也

ORCIDConnect your ORCID iD *help
Researcher Number 30257852
Other IDs
Affiliation (based on the past Project Information) *help 2018 – 2020: 大阪薬科大学, 薬学部, 教授
2011 – 2013: 大阪医科大学, 医学部, 非常勤講師
2008 – 2011: 大阪医科大学, 医学部, 准教授
1995 – 1996: 大阪医科大学, 医学部, 助手
Review Section/Research Field
Principal Investigator
Circulatory organs internal medicine / General physiology
Except Principal Investigator
Basic Section 47060:Clinical pharmacy-related / Ophthalmology / Applied genomics
Keywords
Principal Investigator
Zymography / Remodeling / Matrix metalloproteinase / Electron microscopy / Immunohistochemistry / Collagen / Stiff heart / Cardiomyopathy / 細胞外マトリックス / 心筋生検 … More / 拘束型心筋症 / ザイモグラフィー / リモデリング / マトリックスメタロプロテアーゼ / 電子顕微鏡 / 免疫組織化学 / 間質コラーゲン / 拡張障害 / 心筋症 / 脂質代謝異常 / ラジカル消去 / 心リモデリング / β1受容体遮断薬 / VEGF / 肺高血圧症 / Fos / 大脳辺縁系 / ラジカルスカベンジャー / 水素ガス / 酸化ストレス / 心筋症ハムスター / 糖尿病マウス / 間歇的低酸素負荷 … More
Except Principal Investigator
インフラマソーム反応 / 抗原提示細胞 / cytochrome P450 / DAMPs / インフラマソーム / 反応性代謝物 / 特異体質性薬物性肝障害 / 低酸素負荷マウス / 糖尿病黄斑浮腫 / 抗GBM抗体 / 低酸素負 / 硝子体手術 / 抗IV型コラーゲン抗体 / 抗II型コラーゲン抗体 / 自己免疫 / 糖尿病網膜症 / 眼免疫学 / 等電点電気泳動法 / MALDI / Replica blotting / 等電点二次元電気泳動法 / プロテオミクス / 低酸素ストレス Less
  • Research Projects

    (5 results)
  • Research Products

    (40 results)
  • Co-Researchers

    (10 People)
  •  Mechanisms of idiosyncratic drug induced liver injury focused on inflammasome reaction and development of the evaluation methods.

    • Principal Investigator
      Kato Ryuji
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47060:Clinical pharmacy-related
    • Research Institution
      Osaka University of Pharmaceutical Sciences
  •  A novel strategy using radical scavengers against intermittent hypoxia-induced oxidative stress in heart, kidney, and brainPrincipal Investigator

    • Principal Investigator
      HAYASHI TETSUYA
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General physiology
    • Research Institution
      Osaka Medical College
  •  Autoimmune reaction for vitreous collagen in the pathogenesis of diabetic retinopathy

    • Principal Investigator
      IKEDA Tsunehiko
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Ophthalmology
    • Research Institution
      Osaka Medical College
  •  Proteomic analysis of oxidative stress-responsive proteins in metabolic syndrome

    • Principal Investigator
      SAKAI Akiko
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Applied genomics
    • Research Institution
      Osaka Medical College
  •  THE PATHOGENESIS OF LEFT VENTRICULAR STIFFNESSIN CARDIOMYOPATHIES : ULTRASTRUCTURAL AND IMMUNOHISTOCHEMICAL STUDY.Principal Investigator

    • Principal Investigator
      HAYASHI Tetsuya
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Osaka Medical College

All 2020 2019 2018 2014 2013 2012 2011 2010 2009 2008 Other

All Journal Article Presentation

  • [Journal Article] Reactive metabolite of gefitinib activates inflammasomes: implications for gefitinib-induced idiosyncratic reaction2020

    • Author(s)
      Kato Ryuji、Ijiri Yoshio、Hayashi Tetsuya、Uetrecht Jack
    • Journal Title

      The Journal of Toxicological Sciences

      Volume: 45 Issue: 11 Pages: 673-680

    • DOI

      10.2131/jts.45.673

    • NAID

      130007935160

    • ISSN
      0388-1350, 1880-3989
    • Language
      English
    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K06767
  • [Journal Article] The 2-Hydroxyiminostilbene Metabolite of Carbamazepine or the Supernatant from Incubation of Hepatocytes with Carbamazepine Activates Inflammasomes: Implications for Carbamazepine-Induced Hypersensitivity Reactions2019

    • Author(s)
      Kato Ryuji、Ijiri Yoshio、Hayashi Tetsuya、Uetrecht Jack
    • Journal Title

      Drug Metabolism and Disposition

      Volume: 47 Issue: 10 Pages: 1093-1096

    • DOI

      10.1124/dmd.119.087981

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K06767
  • [Journal Article] Intermittent Hypoxia Accelerates Cardiac Remodeling and Systolic Dysfunction in Cardiomyopathic Hamster2014

    • Author(s)
      Nomura A, Kato R, Ijiri Y, Sakamoto A, Yamaguchi T, Izumi Y, Yoshiyama M, Tanaka K, Hayashi T
    • Journal Title

      Circulation Journal

      Volume: 78 Pages: 1913-1913

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590267
  • [Journal Article] O-Linked N-Acetyl Glucosamine (O-GlcNAc) Regulates Autophagy and Apoptosis in Cardiomyocytes: a Double-Edged Sword in Intermittent Hypoxia-Induced Cardiac Remodeling2014

    • Author(s)
      Hayashi T, Sasaki M, Watanabe A, Furukawa Y, Nakagawa T, Nomura A, Uehashi W, Kato R, Ijiri Y, Yamaguchi T, Izumi Y, Yoshiyama M, Asahi M
    • Journal Title

      J Am Coll Cardiol

      Volume: 63

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590267
  • [Journal Article] Celiprolol reduces oxidative stress and attenuates left ventricular remodelingiInduced by hypoxic stress in mice2013

    • Author(s)
      Nishioka S, Yoshioka T, Nomura A, Kato R, Miyamura M, Okada Y, Ishizaka N, Matsumura Y, Hayashi T
    • Journal Title

      Hypertension Research

      Volume: 36 Issue: 11 Pages: 934-939

    • DOI

      10.1038/hr.2013.60

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590267
  • [Journal Article] Celiprolol reduces oxidative stress and attenuates left ventricular remodelingiInduced by hypoxic stress in mice.2013

    • Author(s)
      Nishioka S, Yoshioka T, Nomura A, Kato R, Miyamura M, Okada Y, Ishizaka N, Matsumura Y, Hayashi T.
    • Journal Title

      Hypertens Res

      Volume: 印刷中

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590267
  • [Journal Article] Preferential suppression of limbic Fos expression by intermittent hypoxia in obese diabetic mice2013

    • Author(s)
      Mukai T, Nagao Y, Nishioka S, Hayashi T, Shimizu S, Ono A, Sakagami Y, Watanabe S, Ueda Y, Hara M, Tokudome K, Kato R, Matsumura Y, Ohno Y
    • Journal Title

      Neuroscience Res

      Volume: 77 Issue: 4 Pages: 202-207

    • DOI

      10.1016/j.neures.2013.09.013

    • Data Source
      KAKENHI-PROJECT-23590267
  • [Journal Article] Influence of capsaicin on fluctuation of digoxin pharmacokinetics in lipopolysaccharide-treated rats.2012

    • Author(s)
      Kato R, Higashitani A, Irie T, Kusukawa Y, Yamamoto Y, Nakagawa M, Urashima Y, Nagata M, Hayashi T, Ijiri Y, Tanaka K.
    • Journal Title

      Xenobiotica

      Volume: 242 Pages: 798-807

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590267
  • [Journal Article] Inhalation of hydrogen gas attenuates left ventricular remodeling induced by intermittent hypoxia in mice2011

    • Author(s)
      Hayashi T, Yoshioka T, Hasegawa K, Miyamura M, Mori T, Ukimura A, Matsumura Y, Ishizaka N
    • Journal Title

      Am J Physiol Heart Circ Physiol

      Volume: 301 Issue: 3 Pages: 1062-1069

    • DOI

      10.1152/ajpheart.00150.2011

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590267
  • [Journal Article] Impact of the renin-angiotensin-aldosterone-system on cardiovascular and renal complications in diabetes mellitus.2010

    • Author(s)
      Hayashi T, Takai S, Yamashita C
    • Journal Title

      Curr.Vasc.Pharmacol 8

      Pages: 189-197

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20510192
  • [Journal Article] Impact of the renin-angiotensin-aldosterone-system on cardiovascular and renal complications in diabetes mellitus.2010

    • Author(s)
      Hayashi T., et al
    • Journal Title

      Curr Vasc Pharmacol

      Volume: 8 Pages: 189-197

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20510192
  • [Journal Article] Chymase plays an important role in left ventricular remodeling induced by intermittent hypoxia in mice.2009

    • Author(s)
      Matsumoto C, Hayashi T, Kitada K, Yamashita C, Miyamura M, Mori T, Ukimura A, Ohkita M, Jin D, Takai S, Miyazaki M, Okada Y, Kitaura Y, Matsumura Y
    • Journal Title

      Hypertension 54

      Pages: 164-171

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20510192
  • [Journal Article] Role of gp91phox-containing NADPH oxidase in left ventricular remodeling induced by intermittent hypoxic stress.2008

    • Author(s)
      Hayashi T
    • Journal Title

      Am. J. Physiol. Heart Circ. Physiol. 294

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20510192
  • [Journal Article] Role of gp91phox-containing NADPH oxidase in left ventricular remodeling induced by intermittent hypoxic stress.2008

    • Author(s)
      Hayashi T, Yamashita C, Matsumoto C, Kwak CJ, Fujii K, Hirata T, Miyamura M, Mori T, Ukimura A, Okada Y, Matsumura Y, Kitaura Y
    • Journal Title

      Am.J.Physiol.Heart Circ.Physiol 294

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20510192
  • [Presentation] The 2-Hydroxyiminostilbene Metabolite of Carbamazepine or the Supernatant from Incubation of Hepatocytes with Carbamazepine Activates Inflammasomes.2020

    • Author(s)
      Kato R, Ijiri Y, Hayashi T, Uetrecht J.
    • Organizer
      59th Annual Meeting and ToxExpo Virtual Meeting (USA)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K06767
  • [Presentation] 血中Acetaminophen(APAP)-グルクロン酸体濃度/APAP比率モニタリングに関する臨床研究報告2019

    • Author(s)
      西澤崚、山本栞、小林岳広、小柳津亨、林実花、加藤隆児、山本浩二郎、大里恭章、井尻好雄、瓜生恭章、原田博雅、林哲也
    • Organizer
      第36回日本TDM学会・学術大会
    • Data Source
      KAKENHI-PROJECT-18K06767
  • [Presentation] Acetaminophen誘発肝障害における免疫担当細胞のシグナル応答2019

    • Author(s)
      加藤隆児、井尻好雄、林哲也、Jack Uetrecht
    • Organizer
      第46回 日本毒性学会学術年会
    • Data Source
      KAKENHI-PROJECT-18K06767
  • [Presentation] ネビラピンの反応性代謝物はinflammasome反応を活性化させるか-ネビラピン誘発肝障害発症機序の検討-2019

    • Author(s)
      加藤 隆児、井尻 好雄、Jack Uetrecht、林 哲也
    • Organizer
      第一回医薬品毒性機序研究会
    • Data Source
      KAKENHI-PROJECT-18K06767
  • [Presentation] 中毒性アセトアミノフェン誘発肝障害は臨床上免疫性に進行し増悪する2019

    • Author(s)
      加藤隆児、井尻好雄、Jack Uetrecht、林哲也
    • Organizer
      第40回日本臨床薬理学会学術総会
    • Data Source
      KAKENHI-PROJECT-18K06767
  • [Presentation] Acetaminophen誘発肝障害発症機序とinflammasome反応との関連性2018

    • Author(s)
      小林岳広、山本栞、小柳津亨、西澤崚、林実花 加藤隆児、井尻好雄、Jack Uetrecht、林哲也
    • Organizer
      第35回日本TDM学会・学術大会
    • Data Source
      KAKENHI-PROJECT-18K06767
  • [Presentation] Amodiaquine and the reactive metabolite activate inflammasomes leading to amodiaquine-induced liver injury and agranulocytosis.2018

    • Author(s)
      Kato R, Ijiri Y, Hirotani Y, Tanaka K, Hayashi T, Uetrecht J.
    • Organizer
      International Congress of Therapeutic Drug Monitoring and Clinical Toxicology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K06767
  • [Presentation] O-Linked N-Acetyl Glucosamine (O-GlcNAc) Regulates Autophagy and Apoptosis in Cardiomyocytes: a Double-Edged Sword in Intermittent Hypoxia-Induced Cardiac Remodeling2014

    • Author(s)
      Hayashi T, Sasaki M, Watanabe A, Furukawa Y, Nakagawa T, Nomura A, Uehashi W, Kato R, Ijiri Y, Yamaguchi T, Izumi Y, Yoshiyama M, Asahi M
    • Organizer
      64th ACC Congress 2014
    • Place of Presentation
      Washington DC, USA
    • Data Source
      KAKENHI-PROJECT-23590267
  • [Presentation] O-Linked N-Acetyl Glucosamine (O-GlcNAc) Regulates Autophagy and Apoptosis in Cardiomyocytes : a Double-Edged Sword in Intermittent Hypoxia-Induced Cardiac Remodeling2014

    • Author(s)
      Hayashi T, Sasaki M, Watanabe A, Furukawa Y, Nakagawa T, Nomura A, Uehashi W, Kato R, Ijiri Y, Yamaguchi T, Izumi Y, Yoshiyama M, Asahi M
    • Organizer
      64th ACC Congress 2014
    • Place of Presentation
      Washington DC, USA
    • Data Source
      KAKENHI-PROJECT-23590267
  • [Presentation] Intermittent hypoxia accelerates cardiac remodeling and systolic dysfunction in cardiomyopathic hamster2014

    • Author(s)
      Nomura A, Kato R, Ijiri Y, Sakamoto A, Yamaguchi T, Izumi Y, Yoshiyama M, Tanaka K, Hayashi T
    • Organizer
      第78回日本循環器学会総会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23590267
  • [Presentation] Role of Vascular Endothelial Growth Factor in Cardiac Remodeling due to Hypoxic Stress2013

    • Author(s)
      Woo E, Nishioka S, NemotoS, Katsumata T, Hayashi T
    • Organizer
      23rd European Meeting on Hypertension & Cardiovascular Protection
    • Place of Presentation
      Milan, Italy
    • Data Source
      KAKENHI-PROJECT-23590267
  • [Presentation] 間歇的低酸素曝露による左室リモデリングに対する新規ARB azilsartanの効果2013

    • Author(s)
      上橋和佳, 野村篤生, 加藤隆児, 宮村昌利, 井尻好雄, 石坂信和, 林哲也
    • Organizer
      第61回日本心臓病学会
    • Place of Presentation
      熊本
    • Data Source
      KAKENHI-PROJECT-23590267
  • [Presentation] Azilsartan reduces oxidative stress and attenuates cardiac remodeling induced by hypoxia in rats2013

    • Author(s)
      Fujiwara Y, Nomura A, Kato R, Miyamura M, Ijiri Y, Ishizama N, Hayashi T
    • Organizer
      第17回日本心不全学会学術集会
    • Place of Presentation
      大宮
    • Data Source
      KAKENHI-PROJECT-23590267
  • [Presentation] 間歇的低酸素負荷に伴う血圧変動と酸化ストレスに対するceliprololの有効性2013

    • Author(s)
      東森健志, 西岡慧, 野村篤生, 加藤隆児, 宮村昌利, 石坂信和, 松村靖夫, 林哲也
    • Organizer
      第36回日本高血圧学会総会
    • Place of Presentation
      大阪
    • Data Source
      KAKENHI-PROJECT-23590267
  • [Presentation] 間歇的低酸素負荷が不全心に及ぼす影響と水素ガスのラジカルスカベンジ効果2013

    • Author(s)
      供田菜々花, 野村篤生, 加藤隆児, 井尻好雄, 宮村昌利, 石坂信和, 阪本英二, 田中一彦, 林哲也
    • Organizer
      第61回日本心臓病学会
    • Place of Presentation
      熊本
    • Data Source
      KAKENHI-PROJECT-23590267
  • [Presentation] 持続的低酸素曝露にともなう心室リモデリングにおけるVEGFの意義と重要性.2012

    • Author(s)
      禹英喜、根本慎太郎、勝間田敬弘、松村靖夫、林哲也.
    • Organizer
      第35回日本高血圧学会総会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-23590267
  • [Presentation] Intermittent hypoxia-induced cardiovascular remodeling in diabetes mellitus.2012

    • Author(s)
      Nomura A, Nishioka S, Yamaguchi S, Tagawa A, Furukawa Y, Kato R, Ijiri Y, Matsumura Y, Okada Y, Asahi M, Tanaka K, Hayashi T.
    • Organizer
      第35回心筋代謝研究会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23590267
  • [Presentation] Effect of hydrogen gas inhalation on lipid metabolism and left ventricular remodeling induced by intermittent hypoxia.2012

    • Author(s)
      Nishioka S, Hayashi T, Miyamura M, Mori T, Ukimura A, Okada Y, Ishizaka N, Yoshioka T, Hasegawa K, Matsumura.
    • Organizer
      ESC Congress 2012
    • Place of Presentation
      Munich
    • Data Source
      KAKENHI-PROJECT-23590267
  • [Presentation] 持続的低酸素曝露にともなう心室リモデリングにおけるVEGFの意義と重要性2012

    • Author(s)
      禹英喜, 根本慎太郎, 勝間田敬弘, 松村靖夫, 林哲也
    • Organizer
      第35回日本高血圧学会総会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-23590267
  • [Presentation] Effect of hydrogen gas inhalation on lipid metabolism and left ventricular remodeling induced by intermittent hypoxia2012

    • Author(s)
      Nishioka S, Hayashi T, Miyamura M, Mori T, Ukimura A, Okada Y, Ishizaka N, Yoshioka T, Hasegawa K, Matsumura
    • Organizer
      ESC Congress 2012
    • Place of Presentation
      Munich
    • Data Source
      KAKENHI-PROJECT-23590267
  • [Presentation] Intermittent hypoxia- induced cardiovascular remodeling in diabetes mellitus2012

    • Author(s)
      Nomura A, Nishioka S, Yamaguchi S, Tagawa A, Furukawa Y, Kato R, Ijiri Y, Matsumura Y, Okada Y, Asahi M, Tanaka K, Hayashi T
    • Organizer
      第35回心筋代謝研究会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23590267
  • [Presentation] Inhalation of hydrogen gas reduces oxidative stress and attenuates cardiac remodeling induced by intermittent hypoxia in mice.2011

    • Author(s)
      Hayashi T.
    • Organizer
      21st European Meeting on Hypertension
    • Place of Presentation
      Milan
    • Data Source
      KAKENHI-PROJECT-23590267
  • [Presentation] ラット網膜血管における一酸化窒素(NO)産生のインスリンに対する反応2010

    • Author(s)
      喜田照代, 奥英弘, 小林崇俊, 池田恒彦
    • Organizer
      第114回日本眼科学会総会
    • Place of Presentation
      名古屋(学術展示)
    • Data Source
      KAKENHI-PROJECT-21592268
  • [Presentation] Efficacy of anti-oxidative beta-blocker on intermittent hypoxia-induced left ventricular remodeling in mice.

    • Author(s)
      Miyamura M, Hayashi T.
    • Organizer
      第75回日本循環器学会総会・学術集会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-23590267
  • [Presentation] 間歇的低酸素曝露によって惹起される左室リモデリングに対するβ-受容体遮断薬の効果.

    • Author(s)
      宮村昌利、林哲也
    • Organizer
      第59回日本心臓病学会学術集会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-23590267
  • [Presentation] 間歇的低酸素負荷にともなう左室リモデリングに対する水素ガス吸入の効果.

    • Author(s)
      林哲也
    • Organizer
      第43回日本臨床分子形態学会総会・学術集会
    • Place of Presentation
      高槻
    • Data Source
      KAKENHI-PROJECT-23590267
  • 1.  SAKAI Akiko (30225750)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 2.  YOSHIDA Hideji (60288735)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  IKEDA Tsunehiko (70222891)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 4.  OKU Hidehiro (90177163)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 5.  SUGIYAMA Tetsuya (20298764)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  ISHIZAKI Eisuke (70530434)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  TAKAI Shinji (80288703)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  Kato Ryuji (30411482)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 8 results
  • 9.  井尻 好雄 (50449823)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results
  • 10.  NAKAIZUMI Atsuko
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

URL: 

Are you sure that you want to link your ORCID iD to your KAKEN Researcher profile?
* This action can be performed only by the researcher himself/herself who is listed on the KAKEN Researcher’s page. Are you sure that this KAKEN Researcher’s page is your page?

この研究者とORCID iDの連携を行いますか?
※ この処理は、研究者本人だけが実行できます。

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi