Shibuya Hiroshi 澁谷浩司

… Alternative Names

澁谷浩司シブヤヒロシ

HIROSHI Shibuya 澁谷浩司

SHIBUYA Kohji 澁谷浩司

澁谷浩史シブヤヒロシ

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Researcher Number	30261324
Other IDs
Affiliation (Current)	2025: 東京科学大学, 総合研究院, 教授
Affiliation (based on the past Project Information) *help	2018 – 2023: 東京医科歯科大学, 難治疾患研究所, 教授 2011 – 2013: 東京医科歯科大学, 難治疾患研究所, 教授 2000 – 2009: 東京医科歯科大学, 難治疾患研究所, 教授 2007: 東京都医科歯科大学, 難治疾患研究所, 教授 2006: 東京医科歯科大学, 難治疾患研所, 教授 1997 – 1999: NIBB,DEV.BIOL., ASSOC.PROFESSOR, 基礎生物学研究所, 助教授 1995 – 1996: 北海道大学, 薬学部, 助教授
Review Section/Research Field	Principal Investigator Basic Section 44010:Cell biology-related / Biological Sciences / Pathological medical chemistry / Cell biology / Developmental biology / Molecular biology / General medical chemistry Except Principal Investigator Developmental biology / Biological pharmacy / Biological Sciences
Keywords	Principal Investigator Wntシグナル / β-catenin / Smad / TAK1 / BMP / NLK / TGF-β / Dlx-5 / BRAM2 / 神経分化 … More / WNK / WNK1 / ユビキチン化 / daf / BIP / BRAM / STAT3 / E3リガーゼ / TGF-βシグナル / Smad4 / Xtwn / ATF2 / 骨分化 / GSK3β / GID complex / RNAi / sma / BRA-1,2 / TGF-b / Dlx5 / BMP受容体 / Lhx8 / 標的遺伝子 / PHAII / OSR1 / 高血圧症 / 頭部形成 / オーガナイザー形成 / BRA-1, 2 / 線虫 / アフリカツメガエル / 中胚葉誘導 / F-boxタンパク / DAF-c / DAF2 / DAF7シグナル / MFB-1 / Atrogin1 / MAFbx / TCF / Wnt / 腹側中胚葉 / Differential display / LHX8 / β-カテニン / Maea. S / HSN2 / E3 ligase / WNK/HSN2 / HSANII / 神経発生 / Sgg / GID omplex / TGF-β signaling / HMG2L1 / Sox 11 / Wnt signaling / mcb-1 / C. elegans / 複合体形成 / LEF1 / ventralization / osteogenesis / 初期応答遺伝子 / 骨芽細胞株MC3T3-E1 / D1x5 / Differential dispaly / Target gene / Two-hydrod system / Signal transducers / BMP receptor / Differential display 法 / DIx-5 / Differential display法 / 酵母two-hybrid system / シグナル伝達分子 / シグナル伝達 / Arroehead / Fray / WNK4 / 細胞内シグナル / Lhx8/Awh / ショウジョウバエ / NKCC2 / NCC / Na^+-Cl^-共輸送体 / SPAK / タンパク分解 / E2-25K / LEF / Mo / 結合因子 / リン酸化 / MEF2A / p38 / NARF / シグナル / CDKインヒビター / signalosome / p27 / Jab1 / Chordin / sox11 / Otx-2 / 神経形成 / Lef1 / 選択的スプライシング / Smad8B / Smad8 / SSXSモチーフ / DIx5 / Yeast two hybrid system … More Except Principal Investigator BMP / Ser / INTRACELLULAR SIGNALING / EPIDERMIS / MSX-1 / TAK1 / TGF-B SUPERFAMILY / XENOPUS LAEVIS / NEURAL INDUCTION / BONE MORPHOGENETIC PROTEIN / フオリスタチン / Thrキナーゼ受容体 / オ-ガナイザー / アフリカツメガエル / 神経形成 / 細胞内情報伝達 / フォリスタチン / TGF-βファミリー / 細胞増殖因子 / 神経誘導 / Signal transduction / Thr kinase / receptor / bone formation / 情報伝達 / スレオニンキナーゼ / セリン / 受容体 / 骨形成 / 安定同位体ラベル / Erkイフェクター / 古典的MAPキナーゼカスケ / ダイレクトナノLC / マップキナーゼカスケード / タンパク質問相互作用 / プロテミクス / Erk / シグナル伝達 / マップキナーゼカスケー / 動態解析 / 質量分析 / プロテオミクス / タンパク質ネットワーク解析 / タンパク質間相互作 Less

Regulation of neural differentiation in Wnt signaling by WNK.Principal Investigator
- Principal Investigator
  
  Shibuya Hiroshi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 44010:Cell biology-related
- Research Institution
  Tokyo Medical and Dental University
Regulation of neural differentiation in Wnt signaling by WNK.Principal Investigator
- Principal Investigator
  
  Shibuya Hiroshi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 44010:Cell biology-related
- Research Institution
  Tokyo Medical and Dental University
Characterization of WNK signaling in developmentPrincipal Investigator
- Principal Investigator
  
  HIROSHI Shibuya
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Tokyo Medical and Dental University
Quantitation analysis of pathway network analysis
- Principal Investigator
  
  NATSUME Tohru
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  National Institute of Advanced Industrial Science and Technology
Regulation of DECODE system in DevelopmentPrincipal Investigator
- Principal Investigator
  
  SHIBUYA Hiroshi
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Medical and Dental University
Regulation of molecular interaction between TGF-β and Wnt signalingsPrincipal Investigator
- Principal Investigator
  
  SHIBUYA Hiroshi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Tokyo Medical and Dental University
負の増殖シグナルの異常と細胞増殖制御の破綻Principal Investigator
- Principal Investigator
  
  澁谷浩司
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Medical and Dental University
Regulation of TGF-b and Wnt signal interactionPrincipal Investigator
- Principal Investigator
  
  SHIBUUYA Hiroshi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cell biology
- Research Institution
  Tokyo Dental and Medical University
TGF-βスーパーファミリー受容体を介するシグナル伝達機構の解析Principal Investigator
- Principal Investigator
  
  澁谷浩司
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Okazaki National Research Institutes
TGF-βシグナルに関与する転写因子の機能解析Principal Investigator
- Principal Investigator
  
  澁谷浩司
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Okazaki National Research Institutes
TGF-βシグナルに関与する転写因子の機能解析Principal Investigator
- Principal Investigator
  
  澁谷浩司
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Okazaki National Research Institutes
TGF-βスーパーファミリー受容体を介するシグナル伝達機構の解析Principal Investigator
- Principal Investigator
  
  澁谷浩司
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Okazaki National Research Institutes
Characterization of new genes for BMP signaling pathway.Principal Investigator
- Principal Investigator
  
  SHIBUYA Hiroshi
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Developmental biology
- Research Institution
  Okazaki National Research Institutes
MOLECULAR MECHANISM FOR NEURAL FROMATION BY BMP
- Principal Investigator
  
  UENO Naoto
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Developmental biology
- Research Institution
  NATIONAL INSTITUTE FOR BASIC BIOLOGY (NIBB)
  Hokkaido University
The establishment of screening system to identify compoundsthat target BMP receptor-associated molecules
- Principal Investigator
  
  UENO Naoto
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Biological pharmacy
- Research Institution
  HOKKAIDO UNIVERSITY
Identification of transducer molecules for BMP signalingPrincipal Investigator
- Principal Investigator
  
  SHIBUYA Hiroshi
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Molecular biology
- Research Institution
  HOKKAIDO UNIVERSITY

All 2023 2022 2020 2019 2018 2013 2012 2011 2010 2009 2008 2007 2006 2005

All Journal Article Presentation

[Journal Article] Rho family small GTPase Rif regulates Wnt5a-Ror1-Dvl2 signaling and promotes lung adenocarcinoma progression2023
- Author(s)
  Nishita Michiru、Kamizaki Koki、Hoshi Kyoka、Aruga Kana、Nishikaku Ikumi、Shibuya Hiroshi、Matsumoto Kunio、Minami Yasuhiro
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 299 Issue: 10 Pages: 105248-105248
- DOI
  10.1016/j.jbc.2023.105248
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15365, KAKENHI-PROJECT-20K07575, KAKENHI-PROJECT-21K06165, KAKENHI-PROJECT-21K18250, KAKENHI-PROJECT-21K15504
[Journal Article] ccl19 and ccl21 affect cell movements and differentiation in early Xenopus development2023
- Author(s)
  Goto T, Michiue T, Shibuya H.
- Journal Title
  
  Dev. Growth. Diff.
  
  Volume: 65 Issue: 3 Pages: 175-189
- DOI
  10.1111/dgd.12847
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06183, KAKENHI-PROJECT-21K06165
[Journal Article] ccr7 affects both morphogenesis and differentiation during early Xenopus embryogenesis2022
- Author(s)
 Goto Toshiyasu、Michiue Tatsuo、Shibuya Hiroshi
- Journal Title
 
 Development, Growth & Differentiation
 
 Volume: 64 Issue: 5 Pages: 254-260
- DOI
 10.1111/dgd.12790
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-21K06165, KAKENHI-PROJECT-21K06183
[Journal Article] Enhanced O-GlcNAc modification induced by the RAS/MAPK/CDK1 pathway is required for SOX2 protein expression and generation of cancer stem cells2022
- Author(s)
  Shimizu Masahiro、Shibuya Hiroshi、Tanaka Nobuyuki
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 2910-2910
- DOI
  10.1038/s41598-022-06916-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06165, KAKENHI-PROJECT-19K16782
[Journal Article] WNK1/HSN2 mediates neurite outgrowth and differentiation via a OSR1/GSK3β-LHX8 pathway2022
- Author(s)
  Shimizu Masahiro、Shibuya Hiroshi
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 15858-15858
- DOI
  10.1038/s41598-022-20271-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06165, KAKENHI-PROJECT-19K16782
[Journal Article] maea affects head formation through ?‐catenin degradation during early Xenopus laevis development2022
- Author(s)
 Goto Toshiyasu、Shibuya Hiroshi
- Journal Title
 
 Development, Growth & Differentiation
 
 Volume: 65 Issue: 1 Pages: 29-36
- DOI
 10.1111/dgd.12828
- Data Source
 KAKENHI-PROJECT-21K06165
[Journal Article] WNK regulates Wnt signalling and β-Catenin levels by interfering with the interaction between β-Catenin and GID2020
- Author(s)
  Sato Atsushi、Shimizu Masahiro、Goto Toshiyasu、Masuno Hiroyuki、Kagechika Hiroyuki、Tanaka Nobuyuki、Shibuya Hiroshi
- Journal Title
  
  Communications Biology
  
  Volume: 3 Issue: 1 Pages: 666-666
- DOI
  10.1038/s42003-020-01386-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16782, KAKENHI-PROJECT-18K06208
[Journal Article] Glycogen synthase kinase 3? functions as a positive effector in the WNK signaling pathway2018
- Author(s)
  Sato Atsushi、Shibuya Hiroshi
- Journal Title
  
  PLOS ONE
  
  Volume: 13 Issue: 3 Pages: e0193204-e0193204
- DOI
  10.1371/journal.pone.0193204
- Data Source
  KAKENHI-PROJECT-18K06208
[Journal Article] WNK Signaling Is Involved in Neural Development via Lhx8/Awh Expression2013
- Author(s)
  Sato, A. and Shibuya, H
- Journal Title
  
  PLoS One
  
  Volume: 8 Issue: 1 Pages: e55301-e55301
- DOI
  10.1371/journal.pone.0055301
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390064, KAKENHI-PROJECT-23790358
[Journal Article] IQGAP1 protein regulates nuclear localization of ・ -catenin via importin- ・ 5 in Wnt signaling2013
- Author(s)
  Goto, T., Sato, A., Shimizu, M., Adachi, S., Satoh, K., Iemura, S., Natsume, T. and Shibuya, H
- Journal Title
  
  J Biol Chem
  
  Volume: 288 Pages: 36351-36360
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390064
[Journal Article] IQGAP1 regulates nuclear localization of β-Catenin via importin-β5 in Wnt signaling.2013
- Author(s)
  Goto. T, Sato, A., Adachi, S., Iemura, S., Natsume, T. and Shibuya, H.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 288 Issue: 51 Pages: 36351-36360
- DOI
  10.1074/jbc.m113.520528
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390064, KAKENHI-PLANNED-24115007, KAKENHI-PROJECT-24590344
[Journal Article] WNK4 is an essential effector of anterior formation in FGF signaling2013
- Author(s)
  Shimizu, M., Goto, T., Sato, A. and Shibuya, H
- Journal Title
  
  Genes Cells
  
  Volume: 18 Issue: 6 Pages: 442-449
- DOI
  10.1111/gtc.12048
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390064, KAKENHI-PROJECT-23790358, KAKENHI-PROJECT-24590344
[Journal Article] IQGAP1 functions as a modulator of Dishevelled nuclear localization in Wnt signaling2013
- Author(s)
  Goto, T., Sato, A., Shimizu, M., Adachi, S., Satoh, K., Iemura, S., Natsume, T. and Shibuya, H
- Journal Title
  
  PLoS One
  
  Volume: 8 Issue: 4 Pages: e60865-e60865
- DOI
  10.1371/journal.pone.0060865
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390064, KAKENHI-PROJECT-23790358, KAKENHI-PLANNED-24115007, KAKENHI-PROJECT-24590344
[Journal Article] Leucine-rich repeat kinase LRRK1 regulates endosomal trafficking of the EGF receptor2011
- Author(s)
  Hanafusa, H., Ishikawa, K., Kedashiro, S., Saigo, T., Iemura, S., Natsume, T., Komada, M., Shibuya, H., Nara, A. and Matsumoto, K.
- Journal Title
  
  Nat Commun
  
  Volume: 2 Pages: 158-158
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390064
[Journal Article] Nemo-like kinase (NLK) expression in osteoblastic cells and suppression of osteoblastic differentiation.2010
- Author(s)
  Nifuji, A., Ideno, H., Ohyama, Y., Takanabe, R., Araki, R., Abe, M., Noda, M., Shibuya, H.
- Journal Title
  
  E x p. C e l l R e s.
- Data Source
  KAKENHI-PROJECT-17054013
[Journal Article] NLK, an essential effector of anterior formation, functions downstream of p38 MAP kinase.2010
- Author(s)
  Ohnishi, E., Goto, T., Sato, A., Kim, M., Iemura, S., Ishitani, T., Natsume, T., Ohnishi, J., Shibuya, H.
- Journal Title
  
  M o l. C e l l. B i o l. 30
  
  Pages: 675-683
- Data Source
  KAKENHI-PROJECT-17054013
[Journal Article] TMEPAI, a transmembrane TGF-b-inducible protein, sequesters Smad proteins from active participation in TGF-b signaling.2010
- Author(s)
  Watanabe, Y., Itoh, S., Goto, T., Ohnishi, E., Inamitsu, M., Itoh, F., Satoh, K., Wiercinska, E., Yang, W., Shi, L., Tanaka, A., Nakano, N., Mommaas, A M., Shibuya, H., ten Dijke, P., Kato, M.
- Journal Title
  
  M o l. C e l l 37
  
  Pages: 123-134
- Data Source
  KAKENHI-PROJECT-17054013
[Journal Article] NLK, an essential effector of anterior formation, functions downstream of p38 MAP kinase.2009
- Author(s)
  Ohnishi, E., T.Goto, A.Sato, M.S.Kim, S.I.Iemura, T.Ishitani, T.Natsume, J.Ohnishi, H.Shibuyaup
- Journal Title
  
  Mol cell Biol. 30
  
  Pages: 675-683
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17017042
[Journal Article] DNA demethylation in hormone-induced transcriptional derepression.2009
- Author(s)
  Kim, M., Kondo, T., Takada, I., Youn, M. -Y., Yamamoto, Y., Takahashi, S., Matsumoto, T., Fujiyama, S., Shirode, Y., Yamaoka, I., Kitagawa, H., Takeyama, K., Shibuya, H., Ohtake, F., Kato, S.
- Journal Title
  
  N a t u r e 461
  
  Pages: 1007-1012
- Data Source
  KAKENHI-PROJECT-17054013
[Journal Article] C. elegans WNK-STE20 pathway regulates tube formation by modulating ClC channel activity.2008
- Author(s)
  Hisamoto, N., Moriguchi, T., Urushiyama, S., Mitani, S., Shibuya, H., Matsumoto, K.
- Journal Title
  
  E M B O R e p. 9
  
  Pages: 70-75
- Data Source
  KAKENHI-PROJECT-17054013
[Journal Article] Molecular pathogenesis of pseudohypoaldosteronism type II: generation and analysis of a Wnk4D561A/+ knock-in mouse model.2007
- Author(s)
  Yang, S. -S., Morimoto, T., Rai, T., Chiga, M., Sohara, E., Ohno, M., Uchida, K., Lin, S. -H., Moriguchi, T., Shibuya, H., Kondo, Y., Sasaki, S., Uchida, S.
- Journal Title
  
  Cell Metabolism 5
  
  Pages: 331-344
- Data Source
  KAKENHI-PROJECT-17054013
[Journal Article] The adaptor-like protein ROG-1 is required for activation of the Ras-MAP kinase pathway and meiotic cell cycle progression in Caenorhabditis elegans.2007
- Author(s)
  Matsubara, Y., Kawasaki, I., Urushiyama, S., Yasuda, T., Shirakata, M., Iino, Y., Shibuya, H., Yamanashi, Y.
- Journal Title
  
  Genes Cells 12
  
  Pages: 407-420
- Data Source
  KAKENHI-PROJECT-17054013
[Journal Article] Nemo-Like Kinase-Myocyte Enhancer Factor 2A Signaling Regulates Anterior Formation in Xenopus Development2007
- Author(s)
  Satoh K, Ohnishi J, Sato A, Takeyama M, Iemura S, Natsume T, Shibuya H.
- Journal Title
  
  Mol Cell Biol 27
  
  Pages: 7623-7630
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17017042
[Journal Article] A histone lysine methyltransferase activated by non-canonical Wnt signalling suppresses PPAR-γtransactivation.2007
- Author(s)
  Takada, I., Mihara, M., Suzawa, M., Ohtake, F., Kobayashi, S., Igarashi, M., Youn, M. -Y., Takeyama, K., Nakamura, T., Mezaki, Y., Takezawa, S., Yogiashi, Y., Kitagawa, H., Yamada, G., Takada, S., Minami, Y., Shibuya, H., Matsumoto, K., Kato, S.
- Journal Title
  
  Nature Cell Biol. 9
  
  Pages: 1273-1285
- Data Source
  KAKENHI-PROJECT-17054013
[Journal Article] NLK-MEF2A signaling regulates anterior formation in Xenopus development.2007
- Author(s)
  Satoh, K., Ohnishi, J., Sato, A., Takeyama, M., Iemura, S., Natsume, T., Shibuya, H.
- Journal Title
  
  Mol. Cell. Biol. 27
  
  Pages: 7623-7630
- Data Source
  KAKENHI-PROJECT-17054013
[Journal Article] NARF, an Nemo-like kinase (NLK)-associated Ring finger protein regulates the ubiquitylation and degradation of T cell factor/Lymphoid enhancer factor (TCF/LEF).2006
- Author(s)
  Yamada, M., Ohnishi, J., Ohkawara, B., Iemura, S., Satoh, K., Hyodo-Miura, J., Kawachi, K., Natsume, T., Shibuya, H.
- Journal Title
  
  J. B i o l. C h e m. 281
  
  Pages: 20749-20760
- Data Source
  KAKENHI-PROJECT-17054013
[Journal Article] Dok-3 sequesters Grb2 and inhibits the Ras-Erk pathway downstream of protein-tyrosine kinases.2006
- Author(s)
  Honma, M., Higuchi, O., Shirakata, M., Yasuda, T., Shibuya, H., Iemura, S., Natsume, T., Yamanashi, Y.
- Journal Title
  
  Genes Cells 11
  
  Pages: 143-151
- Data Source
  KAKENHI-PROJECT-17054013
[Journal Article] NARF, an Nemo-like Kinase (NLK)-associated Ring Finger Protein Regulates the Ubiquitylation and Degradation of T Cell Factor/Lymphoid Enhancer Factor (TCF/LEF).2006
- Author(s)
  Yamada M, Ohnishi J, Ohkawara B, lemura S, Satoh K, Hyodo-Miura J., Kawachi K, Natsume T, Shibuya H
- Journal Title
  
  J Biol Chem. 281 (30)
  
  Pages: 20749-20760
- Data Source
  KAKENHI-PROJECT-17017042
[Journal Article] Functions for proteinases in the ovulatory process.2005
- Author(s)
  Ohnishi, J., Ohnishi, E., Shibuya, H., Takahashi, T.
- Journal Title
  
  Biochim Biophys Acta. 1751
  
  Pages: 95-109
- Data Source
  KAKENHI-PROJECT-17054013
[Journal Article] WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1.2005
- Author(s)
  Moriguchi, T., Urushiyama, S., Hisamoto, N., Iemura, S., Uchida, S., Natsume, T., Matsumoto, K., Shibuya, H.
- Journal Title
  
  J. Biol. Chem. 280
  
  Pages: 42685-42693
- Data Source
  KAKENHI-PROJECT-17054013
[Presentation] SOX2の発現とがん幹細胞の発生には、RAS/MAPK/CDK1経路によって誘導されるO-GlcNAc修飾の増大が必要である2023
- Author(s)
  清水幹容、澁谷浩司、田中信之
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K06165
[Presentation] ccr7 affects both morphogenesis and differentiation during early Xenopus embryogenesis.2022
- Author(s)
  後藤利保、道上達男、澁谷浩司
- Organizer
  第93回日本動物学会年会
- Data Source
  KAKENHI-PROJECT-21K06165
[Presentation] Ror1 signaling through Dvl and Rif promotes invasion of lung adenocarcinoma cells.2019
- Author(s)
  Michiru Nishita, Koki Kamizaki, Ikumi Nishikaku, Hiroshi Shibuya, Kunio Matsumoto, Yasuhiro Minami
- Organizer
  ASCB（米国細胞生物学会）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06208
[Presentation] Ror1 promotes invasion of lung adenocarcinoma cells through small GTPase Rif -mediated filopodia formation2018
- Author(s)
  Michiru Nishita, Ikumi Nishikaku, Eri Yoshida, Koki Kamizaki, Hiroshi Shibuya, Kunio Matsumoto, Yasuhiro Minami
- Organizer
  ASCB（米国細胞生物学会）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06208
[Presentation] GSK3ss functions as a positive effector in WNK signaling pathway.2018
- Author(s)
  Atsushi Sato, Hiroshi Shibuya
- Organizer
  The 13rd Japanese Drosophila Research Conference
- Data Source
  KAKENHI-PROJECT-18K06208
[Presentation] Rif small GTPase mediates Ror1 signaling to induce filopodia formation and invasion of lung adenocarcinoma cells.2018
- Author(s)
  Michiru Nishita, Ikumi Nishikaku, Eri Yoshida, Hiroshi Shibuya, Kunio Matsumoto, and Yasuhiro Minami
- Organizer
  日本細胞生物学会・日本発生生物学会合同年会
- Data Source
  KAKENHI-PROJECT-18K06208
[Presentation] GSK3 fuctions as a positive effector in WNK signaling pathway2018
- Author(s)
  佐藤淳、澁谷浩司
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K06208
[Presentation] IQGAP1によるβ-cateninの核内移行の調節機構の解析2013
- Author(s)
  後藤利保、佐藤淳、足立俊吾、家村俊一郎、夏目徹、澁谷浩司
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23390064
[Presentation] Wnt シグナルにおける DVL とβ -catenin の核移行制御2013
- Author(s)
  澁谷浩司
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  横浜,シンポジウム
- Data Source
  KAKENHI-PROJECT-23390064
[Presentation] IQGAP1 によるβ-catenin の核内移行の調節機構の解析2013
- Author(s)
  後藤利保,佐藤淳,足立俊吾,家村俊一郎,夏目徹, 澁谷浩司
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸,ポスター発表
- Data Source
  KAKENHI-PROJECT-23390064
[Presentation] A new downstream molecule, Awh is involved in the WNK signaling2012
- Author(s)
  佐藤淳,澁谷浩司
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡,口頭発表及びポスター発表
- Data Source
  KAKENHI-PROJECT-23390064
[Presentation] A new downstream molecule, Awh is involved in the WNK signaling2011
- Author(s)
  佐藤淳,澁谷浩司
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  横浜,口頭発表及びポスター発表
- Data Source
  KAKENHI-PROJECT-23390064
[Presentation] A new downstream molecule, Awh is involved in the WNK signaling2011
- Author(s)
  佐藤淳、澁谷浩司
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2011-12-13
- Data Source
  KAKENHI-PROJECT-23390064
[Presentation] an essential effector of anterior formation, functions downstream of p38 MAP kinase.2009
- Author(s)
  後藤利保、大西英理子、佐藤淳、金美善、家村俊一郎、石谷太、夏目徹、大西淳之、澁谷浩司NLK
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2009-12-11
- Data Source
  KAKENHI-PROJECT-17054013
[Presentation] NLK, an essential effector of anterior formation, functions downstream of p38 MAP kinase2009
- Author(s)
  後藤利保、大西英理子、佐藤淳、金美善、家村俊一郎、石谷太、夏目徹、大西淳之、澁谷浩司
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2009-12-11
- Data Source
  KAKENHI-PROJECT-17054013
[Presentation] リン酸化阻害剤によるダウン症治療薬開発アプローチ2009
- Author(s)
  小川靖、吉田実代、大西英理子、平松俊行、小野木博、澁谷浩司、細谷孝充、萩原正敏
- Organizer
  第82回日本薬理学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-17054013
[Presentation] バーキンソン病原因因子LRRK2によるvimentin cage形成2008
- Author(s)
  Strahil Ivanov Pastuhov、花房洋、家村俊一郎、夏目徹、澁谷浩司、稲垣昌樹、松本邦弘
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2008-12-10
- Data Source
  KAKENHI-PROJECT-17054013
[Presentation] Hormonal control of DNA demethylation for gene activation2008
- Author(s)
  Shigeaki Kato, Mi-sun Kim, Hiroshi Shibuya
- Organizer
  Advanced Bone and Joint Science (ABJS) Symposium-Workshop
- Place of Presentation
  Molecular Regulation of Bone and Cartilage
- Data Source
  KAKENHI-PROJECT-17054013
[Presentation] DNA脱メチル化はビタミンD一位水酸化酵素遺伝子の活性型ビタミンD依存的な転写抑制解除を制御する2008
- Author(s)
  金美善, 近藤剛史, 延みんよん, 高田伊知郎, 武山健一, 大竹史明, 澁谷浩司, 加藤茂明
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2008-12-10
- Data Source
  KAKENHI-PROJECT-17054013
[Presentation] Hormonal control of DNA demethylation for gene activation2008
- Author(s)
  Shigeaki Kato, Mi-sun Kim, Hiroshi Shibuya
- Organizer
  Advanced Bone and Joint Science (ABJS) Symposium-Workshop "Molecular Regulation of Bone and Cartilage"
- Place of Presentation
  東京
- Year and Date
  2008-12-02
- Data Source
  KAKENHI-PROJECT-17054013
[Presentation] ダウン症治療薬の創成2008
- Author(s)
  小川靖、吉田実代、大西英理子、平松俊行、小野木博、澁谷浩司、細谷孝充、萩原正敏
- Organizer
  第119回日本薬理学会関東部会
- Place of Presentation
  東京
- Year and Date
  2008-10-04
- Data Source
  KAKENHI-PROJECT-17054013
[Presentation] Dyneinモータータンパク質結合因子Nud CはEGFRの細胞内トラフィックを制御している2008
- Author(s)
  慶田城迅、花房洋、家村俊一郎、夏目徹、澁谷浩司、松本邦弘
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2008-12-12
- Data Source
  KAKENHI-PROJECT-17054013
[Presentation] CRDタンパク質Corinの機能解析2008
- Author(s)
  佐藤淳、Andrew Tomlinson、澁谷浩司
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2008-12-09
- Data Source
  KAKENHI-PROJECT-17054013
[Presentation] LRRKlはESCRT-0複合体と相互作用することでEGFR細胞内トラフィックを制御している2008
- Author(s)
  花房洋、石川光紀、澁谷浩司、駒田雅之、松本邦弘
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2008-12-12
- Data Source
  KAKENHI-PROJECT-17054013
[Presentation] 線虫C.elegansをモデル系としたBAG-2-Hsc70-CHIP複合体によるROCOファミリーキナーゼLRRKの制御機構2008
- Author(s)
  福島沖之、ストラヒルパストゥホフ、花房洋、家村俊一郎、夏目徹、澁谷浩司、松本邦弘、久本直毅
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2008-12-11
- Data Source
  KAKENHI-PROJECT-17054013
[Presentation] LRRKlキナーゼ活性依存的なEGFRの細胞内トラフィッキング制御2008
- Author(s)
  石川光紀、花房洋、澁谷浩司、松本邦弘
- Organizer
  第31回日本分子生物学会年会・第81向日本生化1学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2008-12-12
- Data Source
  KAKENHI-PROJECT-17054013
[Presentation] DNA demethylation for hormone-induced transcriptional derepression2008
- Author(s)
  Mi-sun Kim, Shigeaki Kato, Hiroshi Shibuya
- Organizer
  The 21th NAITO CONFERENCE
- Place of Presentation
  Nuclear Dynamics and RNA[I], Japan
- Data Source
  KAKENHI-PROJECT-17054013
[Presentation] p38-NLKによる頭部形成制御2008
- Author(s)
  澁谷浩司
- Organizer
  第1回XCIJ首都圏支部会(XCIJ-MA)研究集会
- Place of Presentation
  東京
- Year and Date
  2008-10-18
- Data Source
  KAKENHI-PROJECT-17054013
[Presentation] p38 MAPK-NLK経路によるXenopus前頭部形成の制御機構2008
- Author(s)
  大西淳之、大西英理子、家村俊一郎、丸山剛、西頭英起、石谷太、夏目徹、澁谷浩司
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2008-12-12
- Data Source
  KAKENHI-PROJECT-17054013
[Presentation] 「NLKと結合因子による頭部形成制御」文部科学省科学研究費助成金「特定領域研究」2領域2008
- Author(s)
  澁谷浩司
- Organizer
  合同公開シンポジウム
- Place of Presentation
  東京
- Year and Date
  2008-01-08
- Data Source
  KAKENHI-PROJECT-17054013
[Presentation] TMEPAIによるTGF-β/アクチビンシグナル抑制機構2008
- Author(s)
  伊東進、渡邊幸秀、大西英理子、佐藤清敏、澁谷浩司、加藤光保
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2008-12-11
- Data Source
  KAKENHI-PROJECT-17054013
[Presentation] DNA demethylation for hormone-induced transcriptional derepression2008
- Author(s)
 Mi-sun Kim, Shigeaki Kato, Hiroshi Shibuya
- Organizer
 The 21^<th> NAITO CONFERENCE, Nuclear Dyna mics and RNA[I]
- Place of Presentation
 長野
- Year and Date
 2008-06-24
- Data Source
 KAKENHI-PROJECT-17054013
[Presentation] LRRK1はGrb2を介したEGFRエンドサイトーシスを制御する2007
- Author(s)
  花房洋、石川光紀、後藤美樹、家村俊一郎、夏目徹、澁谷浩司、松本邦弘
- Organizer
  第30回日本分子生物学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-17054013
[Presentation] Dyneinモータータンパク質結合因子Nud CによるEGFRの細胞内トラフィック制御2007
- Author(s)
  慶田城迅、花房洋、家村俊一郎、夏目徹、澁谷浩司、松本邦弘
- Organizer
  第30回日本分子生物学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-17054013
[Presentation] Hsp90/Cdc37によるパーキンソン病原因因子LRRK2のキナーゼ活性制御2007
- Author(s)
  パストゥホフ・ストラヒル、花房洋、家村俊一郎、夏目徹、澁谷浩司、松本邦弘
- Organizer
  第30回日本分子生物学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-17054013
[Presentation] LRRK1によるEGFRの細胞内トラフィックの制御2007
- Author(s)
  石川光紀、花房洋、澁谷浩司、松本邦弘
- Organizer
  第30回日本分子生物学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-17054013
[Presentation] 線虫WNK, SPAKおよびCLCチャネルによる水分排出器官の形態制御2006
- Author(s)
  久本直毅、漆山誠一、森口徹生、伊藤健太郎、三谷昌平、澁谷浩司、松本邦弘
- Organizer
  日本分子生物学会2006フォーラム
- Place of Presentation
  名古屋
- Year and Date
  2006-12-09
- Data Source
  KAKENHI-PROJECT-17054013
[Presentation] ユビキチンリガーゼとして機能するNLK結合因子NARFによるWntシグナル制御機構。2005
- Author(s)
  大西淳之、山田美里、大河原美静、澁谷浩司
- Organizer
  第28回日本分子生物学会年会
- Place of Presentation
  福岡
- Year and Date
  2005-12-09
- Data Source
  KAKENHI-PROJECT-17054013
[Presentation] ユビキチンリガーゼとして機能するNLK結合因子NARFによるWntシグナル制御機構。科学技術振興機構戦略的基礎研究推進事業生物の発生・分化・再生研究領域2005
- Author(s)
  山田美里、大河原美静、家村俊一郎、夏目徹、大西淳之、澁谷浩司
- Organizer
  第4回公開シンポジウム
- Place of Presentation
  東京
- Year and Date
  2005-10-04
- Data Source
  KAKENHI-PROJECT-17054013
[Presentation] Dishevelled/IQGAP複合体の細胞内局在制御機構。科学技術振興機構戦略的基礎研究推進事業生物の発生・分化・再生研究領域2005
- Author(s)
  足達俊吾、佐藤清敏、大河原美静、家村俊一郎、夏目徹、大西淳之、澁谷浩司
- Organizer
  第4回公開シンポジウム
- Place of Presentation
  東京
- Year and Date
  2005-10-04
- Data Source
  KAKENHI-PROJECT-17054013
[Presentation] 偽性低アルドステロン症2型の原因遺伝子WNK1プロテインキナーゼはSTE20様キナーゼを介してNa+-Cl-共輸送体のN末制御領域をリン酸化する。2005
- Author(s)
  森口徹生、漆山誠一、久本直毅、家村俊一郎、内田信一、夏目徹、松本邦弘、澁谷浩司
- Organizer
  第28回日本分子生物学会年会
- Place of Presentation
  福岡
- Year and Date
  2005-12-09
- Data Source
  KAKENHI-PROJECT-17054013

1. URUSHIYAMA Seiichi (30334428)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. SHIRAKABE Kyoko (00345315)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. UENO Naoto (40221105)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. NATSUME Tohru (00357683)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
5. IEMURA Shun-ichiro (90356410)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. NAKAYAMA hiroshi (80321793)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. OHNISHI Junji (40261276)

# of Collaborated Projects: 1 results

# of Collaborated Products: 14 results
8. SATOH Kiyotoshi (50401386)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
9. MORIGUCHI Tetsuo (40323571)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
10. KIM Misun (70508332)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
11. SATO Atsushi (30451925)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
12. GOTO Toshiyasu (00517518)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
13. NAKAMURA Makoto (30212103)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 加藤順也 (00273839)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 松尾律子 (00126260)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. KATSUMATA Takashi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 星京香

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 道上達男

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 清水幹容

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Shibuya Hiroshi 澁谷 浩司

澁谷 浩司 シブヤ ヒロシ

HIROSHI Shibuya 澁谷 浩司

SHIBUYA Kohji 澁谷 浩司

澁谷 浩史 シブヤ ヒロシ

Research Projects

Research Products

Co-Researchers

Regulation of neural differentiation in Wnt signaling by WNK.Principal Investigator

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Regulation of neural differentiation in Wnt signaling by WNK.Principal Investigator

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Characterization of WNK signaling in developmentPrincipal Investigator

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Quantitation analysis of pathway network analysis

Principal Investigator

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Regulation of DECODE system in DevelopmentPrincipal Investigator

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Regulation of molecular interaction between TGF-β and Wnt signalingsPrincipal Investigator

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負の増殖シグナルの異常と細胞増殖制御の破綻Principal Investigator

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Regulation of TGF-b and Wnt signal interactionPrincipal Investigator

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TGF-βスーパーファミリー受容体を介するシグナル伝達機構の解析Principal Investigator

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TGF-βシグナルに関与する転写因子の機能解析Principal Investigator

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TGF-βシグナルに関与する転写因子の機能解析Principal Investigator

Principal Investigator

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TGF-βスーパーファミリー受容体を介するシグナル伝達機構の解析Principal Investigator

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Characterization of new genes for BMP signaling pathway.Principal Investigator

Principal Investigator

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Shibuya Hiroshi 澁谷浩司

澁谷浩司シブヤヒロシ

HIROSHI Shibuya 澁谷浩司

SHIBUYA Kohji 澁谷浩司

澁谷浩史シブヤヒロシ