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OKA Chio  岡 千緒

… Alternative Names

Oka Chio  岡 千緒

岡 千緒  オカ チオ

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Researcher Number 30263445
Other IDs
  • ORCIDhttps://orcid.org/0000-0001-9352-461X
Affiliation (Current) 2025: 奈良先端科学技術大学院大学, 先端科学技術研究科, 助教
Affiliation (based on the past Project Information) *help 2019 – 2023: 奈良先端科学技術大学院大学, 先端科学技術研究科, 助教
2007: Nara Institute of Science and Technology, School of Biological Sciences, Assistant Professor
2004 – 2006: 奈良先端科学技術大学院大学, バイオサイエンス研究科, 助手
2000 – 2001: 奈良先端科学技術大学院大学, バイオサイエンス研究科, 助手
1996: 奈良先端科学技術大学院大学, バイオサイエンス研究科, 助手
Review Section/Research Field
Principal Investigator
Basic Section 56060:Ophthalmology-related / Pathological medical chemistry / Developmental biology
Except Principal Investigator
Basic Section 56020:Orthopedics-related / General medical chemistry / Pathological medical chemistry / General medical chemistry
Keywords
Principal Investigator
オートファジー / 加齢黄斑変性 / HtrA1 / ノックアウトマウス / TGF-β / セリンプロテアーゼ / プロテアーゼ / プロテアーゼの基質 / 酸化ストレス / Clusterin … More / クラステリン / 網膜色素上皮細胞 / knockout mouse / hypertrophic chondrocyte / serine protease / arthritis / 骨分化 / collagen / GFG / コラーゲン / HtrA1セリンプロテアーゼ / 肥大化軟骨 / HtrAl / 関節炎 / 分子生物学 / 側方抑制 / 細胞運命決定 … More
Except Principal Investigator
HtrA1 / 遺伝子破壊マウス / コラーゲン / 糖鎖 / 免疫学 / シグナル伝達 / 破骨細胞 / 骨代謝 / Hypertrophic chondrocvte / Calcification / Osteocalcine / Bone density / C-pronentide / Collagens / Osteoarthritis / 骨芽細胞 / 肥大軟骨 / TGF-β / プロテオグリカン / 細胞外基質 / 骨芽細胞分化 / 軟骨分化 / bFGF / 加齢黄斑変性症 / 関節炎 / HtrAセリンプロテアーゼ / 肥大軟骨細胞 / 石灰化 / オステオカルシン / 骨密度 / C-プロペプチド / コラーゲン分泌 / 変形性関節炎 / HtrAl / アミロイドβ / NPXYモチーフ / PICK1 / JNKスカフォールド / LRP1B / MAPキナーゼカスケード / グルタミン酸受容体 / 細胞内取り込み / 晩発性アルツハイマー病 / JNK / JIP-1 / PICK-1 / LDL受容体ファミリー / 蛋白質分解酵素阻害剤 / セリン蛋白質分解酵素 / フォリスタチン様ドメイン / 軟骨細胞 / 関節炎モデル動物 / フォリスタチン様蛋白質 / 細胞外期質 / 変形性骨関節炎 / TGF-βファミリー / セリンプロテアーゼ Less
  • Research Projects

    (8 results)
  • Research Products

    (12 results)
  • Co-Researchers

    (4 People)
  •  加齢黄斑変性の発症に関わるセリンプロテアーゼHtrA1の基質の同定と機能解析Principal Investigator

    • Principal Investigator
      岡 千緒
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56060:Ophthalmology-related
    • Research Institution
      Nara Institute of Science and Technology
  •  破骨細胞におけるDAP12を介したITAMシグナル経路を制御する分子機構の解明

    • Principal Investigator
      北川 教弘
    • Project Period (FY)
      2021 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56020:Orthopedics-related
    • Research Institution
      Nara Institute of Science and Technology
  •  Functional analysis of AMD related serine protease HtrA1Principal Investigator

    • Principal Investigator
      Oka Chio
    • Project Period (FY)
      2019 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56060:Ophthalmology-related
    • Research Institution
      Nara Institute of Science and Technology
  •  Study on HtrA Serine Protea we Family Proteins Which Inhibit Signaling of TGF-βs

    • Principal Investigator
      KAWAICHI Masashi
    • Project Period (FY)
      2005 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General medical chemistry
    • Research Institution
      Nara Institute of Science and Technology
  •  How HtrA1 serine protease inhibit TGF-β signal and is involved in arthritis ?Principal Investigator

    • Principal Investigator
      OKA Chio
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Nara Institute of Science and Technology (NAIST)
  •  新しいアルツハイマー病関連遺伝子LRP1Bの研究

    • Principal Investigator
      川市 正史
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Nara Institute of Science and Technology
  •  セリンプロテアーゼ、S8の阻害による関節炎発症抑制の検討

    • Principal Investigator
      KAWAICHI Masashi
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      General medical chemistry
    • Research Institution
      Nara Institute of Science and Technology
  •  P19細胞および網膜細胞の分化系におけるNotchシグナル伝達経路の解明Principal Investigator

    • Principal Investigator
      岡 千緒
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Developmental biology
    • Research Institution
      Nara Institute of Science and Technology

All 2021 2019 2006 2005

All Journal Article Presentation

  • [Journal Article] Associations of ARMS2 and CFH Gene Polymorphisms with Neovascular Age-Related Macular Degeneration2021

    • Author(s)
      Supanji Supanji、Romdhoniyyah Dewi Fathin、Sasongko Muhammad Bayu、Agni Angela Nurini、Wardhana Firman Setya、Widayanti Tri Wahyu、Prayogo Muhammad Eko、Perdamaian Ayudha Bahana Ilham、Dianratri Aninditta、Kawaichi Masashi、Oka Chio
    • Journal Title

      Clinical Ophthalmology

      Volume: Volume 15 Pages: 1101-1108

    • DOI

      10.2147/opth.s298310

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K09950
  • [Journal Article] High-Temperature Requirement A1 Protease as a Rate-Limiting Factor in the Development of Osteoarthritis2019

    • Author(s)
      Chen PH, Tang T, Liu C, Wang B, Mian M, Oka C, Baquerizo M, Li Y, Xu L.
    • Journal Title

      Am J Pathol

      Volume: 9(1) Issue: 1 Pages: 18224-18224

    • DOI

      10.1038/s41598-019-54807-6

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K09950
  • [Journal Article] High-Temperature Requirement A1 Protease as a Rate-Limiting Factor in the Development of Osteoarthritis2019

    • Author(s)
      Chen PH, Tang T, Liu C, Wang B, Mian M, Oka C, Baquerizo M, Li Y, Xu L.
    • Journal Title

      Am J Pathol.

      Volume: 189(7) Issue: 7 Pages: 1423-1434

    • DOI

      10.1016/j.ajpath.2019.03.013

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K09950
  • [Journal Article] Expression of mouse HtrA1 serine protease in normal bone and cartilage and its upregulation in joint cartilage damaged by experimental arthritis2005

    • Author(s)
      Tsuchiya, A., Yano, M., Tocharus, J., Kojima, H., Fukumoto, M., Kawaichi, M., Oka, C
    • Journal Title

      Bone 37

      Pages: 323-336

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390079
  • [Journal Article] Expression of mouse HtrA1 serine protease in normal bone and cartilage and its upregulation in joint cartilage damaged by experimental arthritis.2005

    • Author(s)
      Tsuchiya, A., Yano, M., Tocharus, J., Kojima, H., Fukumoto, M., Kawaichi, M., Oka, C.
    • Journal Title

      Bone 37

      Pages: 323-336

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590268
  • [Journal Article] Expression of mouse HtrA1 serine protease in normal bone and cartilage and its upregulation in joint cartilage damaged by experimental arthritis.2005

    • Author(s)
      Tsuchiya, A., Yano, M., Tocharus, J., Kojima, H., Fukumoto, M., Kawaichi, M., Oka, C
    • Journal Title

      Bone 37

      Pages: 323-336

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590268
  • [Journal Article] Expression of mouse HtrAl serine protease in normal bone and cartilage and its upregulation in joint cartilage damaged by experimental arthritis2005

    • Author(s)
      Tsuchiya, A., Yano, M., Tocharus, J., Kojima, H., Fukumoto, M., Kawaichi, M. and Oka, C.
    • Journal Title

      Bone 37

      Pages: 323-336

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17390079
  • [Presentation] 「HtrA1の病態生化学と創薬ターゲットとしての可能性」2019

    • Author(s)
      岡千緒
    • Organizer
      日本病態プロテアーゼ学会、第24回学術集会シンポジウム
    • Invited
    • Data Source
      KAKENHI-PROJECT-19K09950
  • [Presentation] Roles of mouse HtrA1 serine protease in bone development and pathogenesis of osteoarthritis2006

    • Author(s)
      Hisae, Kojima, Akiho, Tsuchiya, Masashi, Kawaichi, Chio, Oka
    • Organizer
      20th IUBMB International Congress
    • Place of Presentation
      Kyoto
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390079
  • [Presentation] Mammalian HtrAl is a highly regulated serine protease2006

    • Author(s)
      Chio Oka, Murwantoko, Masato Yano, Yoshifumi Ueta, Hisae Kojima, Akiho Tsuchiya, Masashi Kawaichi
    • Organizer
      20th IUBMB International Congress.
    • Place of Presentation
      Kyoto
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17390079
  • [Presentation] Roles of mouse HtrAl serine protease in bone development and pathogenesis of osteoarthritis2006

    • Author(s)
      Hisae Kojima, Akiho Tsuchiya, Masashi Kawaichi, Chio Oka
    • Organizer
      20th IUBMB International Congress.
    • Place of Presentation
      Kyoto
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17390079
  • [Presentation] Mammalian HtrA1 is a highly regulated serine protease2006

    • Author(s)
      Chio, Oka, Murwantoko, Masato, Yano, Yoshifumi, Ueta, Hisae, Kojima, Akiho, Tsuchiya, Masashi, Kawaichi
    • Organizer
      20th IUBMB International Congress
    • Place of Presentation
      Kyoto
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390079
  • 1.  KAWAICHI Masashi (00195041)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 8 results
  • 2.  北川 教弘 (30294284)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  別所 康全 (70261253)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  山下 照仁 (90302893)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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