Mizuno Toshiki 水野敏樹

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MIZUNO Toshiki 水野敏樹

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Researcher Number	30264782
Other IDs
Affiliation (Current)	2025: 京都府立医科大学, 医学(系)研究科(研究院), 特任教授
Affiliation (based on the past Project Information) *help	2023: 京都府立医科大学, 医学(系)研究科(研究院), 特任教授 2013 – 2022: 京都府立医科大学, 医学(系)研究科(研究院), 教授 2014: 京都府立医科大, 医学(系)研究科(研究院), 教授 2014: 京都府立医科大学, 大学院医学研究科, 教授 2012: 京都府立医科大学, 大学院・医学研究科, 准教授 … More 2011 – 2012: 京都府立医科大学, 医学(系)研究科(研究院), 准教授 2010 – 2011: 京都府立医科大学, 医学研究科, 准教授 2008: 京都府立医科大学, 大学院・医学研究科, 准教授 2007 – 2008: 京都府立医科大学, 医学研究科, 准教授 2004 – 2005: 京都府立医科大学, 医学研究科, 助教授 2001: Kyoto Prefectural University of Medicine, Neurology, Assistant Professor, 医学部, 助教授 2000 – 2001: 京都府立医科大学, 医学部, 講師 1999: 京都府立医科大学, 医学部, 助手 1995 – 1997: 京都府立医科大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Neurology / Basic Section 52020:Neurology-related / Public health/Health science / Cerebral neurosurgery Except Principal Investigator Neurology / Basic Section 52020:Neurology-related / Public health/Health science / Hygiene and public health / Basic Section 58030:Hygiene and public health-related: excluding laboratory approach / Cognitive science / Neurology / Epidemiology and preventive medicine
Keywords	Principal Investigator 脳小血管病 / Neurosin / serine protease / CADASIL / フラクタル解析 / NAC domain / α-synuclein / アルツハイマー / レビー小体型痴呆 / パーキンソン病 … More / アルツハイマー病 / レビー小体 / セリンプロテアーゼ / parkinson / alfa-synuclein / neurosin / molecular epidemiology / Apolipoprotein E(ApoE) / Dementia of Alzheimer type / アポリポ蛋白E(ApoE) / アポリポタンパクE / 分子疫学 / アポリポ蛋白E / 老年期痴呆 / trasnendocytosis / Notch3 / Notch / transendocytosis / NOTCH3 / 遺伝性脳小血管病 / 脳腎連関 / TGFβ / 高血圧モデルラット / 脳小血管病変 / TGF β … More Except Principal Investigator 大脳白質病変 / CADASIL / 軽度認知機能障害 / NOTCH3 / 脳小血管病 / 認知症 / パーキンソン病 / 虚血性深部白質病変 / 頭部MRI 検査 / α-シヌクレイン / 脳MRI / ヒストグラム解析 / Radiomics / バイオバンク / NOTCH3バリアント / 一般集団 / 遺伝要因 / 白質病変 / 東北メディカル・メガバンク / 追跡調査 / 血管作動性物質アドレノメヂュリン / 虚血性深部白質病変 / 血管作動性物質アドレノメ / 長期追跡調査 / 頭部MRI検査 / 血管作動性物質アドレノデュリン / 頭部ＭＲＩ / 頭部MRI / 15年目前向き追跡研究 / 認知症検診 / 予知診断マーカー / 遺伝学 / 遺伝子 / 脳神経疾患 / 小血管病 / 遺伝性疾患 / エキソーム解析 / 脳白質疾患 / 認知科学 / 機能的 MRI / fMRI / 機能的MRI / 表情認知 / 扁桃体 / 機能的磁気共鳴画像法 / 顔表情認知 / 側頭葉てんかん / αsynuclein / リポ蛋白 / 脂質 / α-synuclein / STROKE / Iacunar infarction / lacunar infarction / vascular dementia / Notch3 / 遺伝子多型 / 脳血管障害 / 疾患モデル / 遺伝性脳小血管病 / Notch / ショウジョウバエ / 拡散強調画像 / 脳血管性認知症 / q space imaging / MRI / 10年間の追跡調査 / TGFβ-１ / 前向き調査研究 / 血管性性認知症 / 認知機能低下 / TGFβ1 / 慢性腎臓病 / TGF-β１ / 慢性炎症 / 脳内深部白質病変 / サイトカイン / TGF-beta1 / A30P変異α-シヌクレイン / 原子間力顕微鏡 / 神経細胞変性 / アルファ・シヌクレイン / 分子標的治療 / 神経細胞毒性 / オリゴマー / 動脈硬化 / 追跡研究 / 発生要因 / リスク要因 / 疫学 / 危険要因 / GFP / 小胞体 / 培養細胞 / 蛋白分解 / セリンプロテアーゼ / 蛋白質分解 / 酵素 / ニューロシン / 脳虚血 / 動脈硬化症 Less

Etiological diagnosis and outcome prediction in brain white matter lesions by radiomics analysis
- Principal Investigator
  
  尾原知行
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Kyoto Prefectural University of Medicine
Cerebral white matter lesions and cerebral small vessel disease-related gene variants in the Japanese general population
- Principal Investigator
  
  水田依久子
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Kyoto Prefectural University of Medicine
analysisis about the develpoment of cerebral white matter lesion by fractal geometryPrincipal Investigator
- Principal Investigator
  
  水野敏樹
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Kyoto Prefectural University of Medicine
A 15-year prospective follow-up study on the causes of dementia and new predictive diagnostic markers
- Principal Investigator
  
  Kuriyama Nagato
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 58030:Hygiene and public health-related: excluding laboratory approach
- Research Institution
  Kyoto Prefectural University of Medicine
The mechanism of facial cognitive function in temporal lobe epilepsy
- Principal Investigator
  
  TANAKA AKIHIRO
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cognitive science
- Research Institution
  Kyoto Prefectural University of Medicine
Research on genetic pathomechanism of adult-onset white matter disease
- Principal Investigator
  
  Yoshida Tomokatsu
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Kyoto Prefectural University of Medicine
Investigation of lipid associated alpha-synuclein metabolism
- Principal Investigator
  
  Kasai Takashi
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Kyoto Prefectural University of Medicine
The prospective study about association between mid-regional proadrenomedullin levels and progression of deep white matter lesions in the brain accompanying vascular cognitive decline
- Principal Investigator
  
  Kuriyama Nagato
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hygiene and public health
- Research Institution
  Kyoto Prefectural University of Medicine
Pathomechanism of cerebral small vessel disease due to disturbance of transendocytosisPrincipal Investigator
- Principal Investigator
  
  Mizuno Toshiki
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Kyoto Prefectural University of Medicine
Investigation of cerebral small vessel diseases using Notch3 transgenic Drosophila
- Principal Investigator
  
  Mizuta Ikuko
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Kyoto Prefectural University of Medicine
TGF-beta1 is associated with the progression of intracranial deep white matter lesions: a pilot study with 5 years of MRI evaluation
- Principal Investigator
  
  KURIYAMA Nagato
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Public health/Health science
- Research Institution
  Kyoto Prefectural University of Medicine
Clinical application of q space imaging
- Principal Investigator
  
  MAKINO Masahiro
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Kyoto Prefectural University of Medicine
Prospective study on the risk factor of mild cognitive impairment
- Principal Investigator
  
  WATANABE Yoshiyuki
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Epidemiology and preventive medicine
- Research Institution
  Kyoto Prefectural University of Medicine
Elucidation of characters and neurotoxic mechanisms of alpha-synuclein oligomers and its application to molecular targeted therapy
- Principal Investigator
  
  TOKUDA Takahiko
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Kyoto Prefectural University of Medicine
Pathomechanism of cerebral small vessel induced by TGFβ1 signallingPrincipal Investigator
- Principal Investigator
  
  MIZUNO Toshiki
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Kyoto Prefectural University of Medicine
Exploration of intracellular protease property and control factors of neurosin with α-synuclein degrading activity
- Principal Investigator
  
  TOKUDA Takahiko
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Kyoto Prefectural University of Medicine
A longitudinal study on risk factors of mild dementia
- Principal Investigator
  
  WATANABE Yoshiyuki
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Public health/Health science
- Research Institution
  Kyoto Prefectural University of Medicine
Cleavage of α-sunuclein by Neurosin (Kallikrein-6)Principal Investigator
- Principal Investigator
  
  MIZUNO Toshiki
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Kyoto Prefectural University of Medicine
NOTCH3 gene polymorphism in Japanese stroke patients
- Principal Investigator
  
  MAKINO Masahiro
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  KYOTO Prefectural University of Medicine
MOLECULAR EPIDEMIOLOGY OF APOLIPOPROTEIN E AND VITAMIN D RECEPTOR IN NORTHERN PART OF KYOTO PREFECTUREPrincipal Investigator
- Principal Investigator
  
  MIZUNO Toshiki
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Public health/Health science
- Research Institution
  Kyoto Prefectural University of Medicine

[Journal Article] Progress to Clarify How NOTCH3 Mutations Lead to CADASIL, a Hereditary Cerebral Small Vessel Disease2024
- Author(s)
  Mizuta Ikuko、Nakao-Azuma Yumiko、Yoshida Hideki、Yamaguchi Masamitsu、Mizuno Toshiki
- Journal Title
  
  Biomolecules
  
  Volume: 14 Issue: 1 Pages: 127-127
- DOI
  10.3390/biom14010127
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07441
[Journal Article] Association between cerebrovasoreactivity and stroke in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy2023
- Author(s)
  Mukai Mao、Hamano Ai、Mizuta Ikuko、Yokota Isao、Watanabe-Hosomi Akiko、Matsuura Hiraku、Koizumi Takashi、Matsuura Jun、Ohara Tomoyuki、Matsushima Shigenori、Teramukai Satoshi、Yamada Kei、Mizuno Toshiki
- Journal Title
  
  Frontiers in Neurology
  
  Volume: 13 Pages: 1087220-1087220
- DOI
  10.3389/fneur.2022.1087220
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10414, KAKENHI-PROJECT-22K07521
[Journal Article] A 10-year longitudinal study of deep white matter lesions on magnetic resonance imaging.2021
- Author(s)
  Tamura A, Kuriyama N, Akazawa K, Ozaki E, Watanabe I, Ohshima Y, Kondo M, Takezawa N, Takada A, Matsumoto S, Takeda K, Yoshii K, Yamada K, Watanabe Y, Nakagawa M, Mizuno T.
- Journal Title
  
  Neuroradiol
  
  Volume: Online ahead of print Issue: 10 Pages: 1599-1609
- DOI
  10.1007/s00234-020-02626-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H03052, KAKENHI-PROJECT-19K08233
[Journal Article] Evaluation of myostatin as a possible regulator and marker of skeletal muscle-cortical bone interaction in adults.2020
- Author(s)
  Kuriyama N, Ozaki E, Koyama T, Matsui D, Watanabe I, Tomida S, Nagamitsu R, Hashiguchi K, Inaba M, Yamada S, Horii M, Mizuno S, Yoneda Y, Kurokawa M, Kobayashi D, Fukuda S, Iwasa K, Watanabe Y, Uehara R.
- Journal Title
  
  J Bone Miner Metab
  
  Volume: 39 Issue: 3 Pages: 404-415
- DOI
  10.1007/s00774-020-01160-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H03052
[Journal Article] Adult-onset leukoencephalopathy with homozygous LAMB1 missense mutation2020
- Author(s)
  Yasuda R, Yoshida T, Mizuta I, Watanabe M, Nakano M, Sato R, Tokuda Y, Omi N, Sakai N, Nakagawa M, Tashiro K, Mizuno T.
- Journal Title
  
  Neurology Genetics
  
  Volume: -
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09698
[Journal Article] Plasma neurofilament light chain: A potential prognostic biomarker of dementia in adult Down syndrome patients2019
- Author(s)
  Shinomoto Makiko、Kasai Takashi、Tatebe Harutsugu、Kondo Masaki、Ohmichi Takuma、Morimoto Masafumi、Chiyonobu Tomohiro、Terada Naoto、Allsop David、Yokota Isao、Mizuno Toshiki、Tokuda Takahiko
- Journal Title
  
  PLOS ONE
  
  Volume: 14 Issue: 4 Pages: e0211575-e0211575
- DOI
  10.1371/journal.pone.0211575
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09319, KAKENHI-PROJECT-18K07506, KAKENHI-PROJECT-18K15461
[Journal Article] Prevalence of adult epilepsy in a general Japanese population: The Hisayama study2019
- Author(s)
  Tanaka Akihiro、Hata Jun、Akamatsu Naoki、Mukai Naoko、Hirakawa Yoichiro、Yoshida Daigo、Kishimoto Hiro、Ohara Tomoyuki、Mizuno Toshiki、Tsuji Sadatoshi、Kitazono Takanari、Ninomiya Toshiharu
- Journal Title
  
  Epilepsia Open
  
  Volume: 4 Issue: 1 Pages: 182-186
- DOI
  10.1002/epi4.12295
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K00210, KAKENHI-PROJECT-16H02644, KAKENHI-PROJECT-17K09113, KAKENHI-PROJECT-17K09808
[Journal Article] Increased levels of plasma total tau in adult Down syndrome2018
- Author(s)
  Kasai T, Tatebe H, Kondo M, Ishii R, Ohmichi T, Yeung WTE, Morimoto M, Chiyonobu T, Terada N, Allsop D, Nakagawa M, Mizuno T, Tokuda T.
- Journal Title
  
  Plos One
  
  Volume: 12 Issue: 11 Pages: e0188802-e0188802
- DOI
  10.1371/journal.pone.0188802
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09319, KAKENHI-PROJECT-15K09322
[Journal Article] Biomarker repurposing: Therapeutic drug monitoring of serum theophylline offers a potential diagnostic biomarker of Parkinson’s disease2018
- Author(s)
  Ohmichi Takuma、Kasai Takashi、Kosaka Tadashi、Shikata Keisuke、Tatebe Harutsugu、Ishii Ryotaro、Shinomoto Makiko、Mizuno Toshiki、Tokuda Takahiko
- Journal Title
  
  PLOS ONE
  
  Volume: 13 Issue: 7 Pages: e0201260-e0201260
- DOI
  10.1371/journal.pone.0201260
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07506, KAKENHI-PROJECT-18K15461, KAKENHI-PROJECT-15K09319
[Journal Article] New diagnostic criteria for cerebral autosomal dominant arteriopathy with subcortical infarcts and leukocencephalopathy in Japan.2017
- Author(s)
  Mizuta I, Hosomi-Watanabe A, Koizumi T, Mukai M, Hamano A, Tomii Y, Kondo M, Nakagawa M, Tomimoto H, Hirano T, Uchino M, Onodera O, Mizuno T
- Journal Title
  
  J Neurol Sci
  
  Volume: 381 Pages: 62-67
- DOI
  10.1016/j.jns.2017.08.009
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09731, KAKENHI-PROJECT-15H05293, KAKENHI-PROJECT-26461276
[Journal Article] Association between mid-regional proadrenomedullin levels and progression of deep white matter lesions in the brain accompanying cognitive decline.2017
- Author(s)
  Kuriyama N, Ihara M, Mizuno T, Ozaki E, Matsui D, Watanabe I, Koyama T, Kondo M, Tokuda T, Tamura A, Yamada K, Akazawa K, Takeda K, Takada A, Mizuno S, Nakagawa M, Watanabe Y.
- Journal Title
  
  J Alzheimers Dis
  
  Volume: 56 Issue: 4 Pages: 1253-1262
- DOI
  10.3233/jad-160901
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08812
[Journal Article] Early-onset parkinsonism in a pedigree with phosphoglycerate kinase deficiency and a heterozygous carrier: Do PGK-1 mutations contribute to vulnerability to parkinsonism?2017
- Author(s)
  Sakaue S, Kasai T, Osone S, Azuma Y, Imamura T, Mizuta I, Tokuda T, Kanno H, El-Agnaf OM, Morimoto M, Hosoi H, Mizuno T.
- Journal Title
  
  npj Parkinson Disease
  
  Volume: 3 Issue: 1 Pages: 1-3
- DOI
  10.1038/s41531-017-0014-4
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09319, KAKENHI-PROJECT-15K09322
[Journal Article] CADASILの臨床像と遺伝子異常2017
- Author(s)
  渡邉明子, 水田依久子, 水野敏樹
- Journal Title
  
  神経内科
  
  Volume: 87 Pages: 630-637
- Data Source
  KAKENHI-PROJECT-26461276
[Journal Article] Abeta levels in the jugular vein and high molecular weight Abeta oligomer levels in CSF can be used as biomarkers to indicate the anti-amyloid effect of IVIg for Alzheimer's disease.2017
- Author(s)
  Kasai T, Kondo M, Ishii R, Tanaka A, Ataka S, Shimada H, Tomiyama T, Mori H, Taylor M, Allsop D, Nakagawa M, Mizuno T, Tokuda T.
- Journal Title
  
  Plos One
  
  Volume: 11 Issue: 4 Pages: e0174630-e0174630
- DOI
  10.1371/journal.pone.0174630
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09319, KAKENHI-PROJECT-15K09322
[Journal Article] A Japanese CADASIL kindred with a novel two-base NOTCH3 mutation.2016
- Author(s)
  Suda, Satoshi; Okubo, Seiji; Ueda, Masayuki; Sowa, Kota; Abe, Arata; Aoki, Junya; Muraga, Kanako; Suzuki, Kentaro; Sakamoto, Yuki; Mizuta, Ikuko; Mizuno, Toshiki; Kimura, Kazumi.
- Journal Title
  
  Eur J Neurol
  
  Volume: 23 Issue: 5 Pages: 32-34
- DOI
  10.1111/ene.12977
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461276
[Journal Article] CADASIL Presenting as Acute Bilateral Multiple Subcortical Infarcts without a Characteristic Temporal Pole or Any External Capsule Lesions2016
- Author(s)
  Takashi Ando, Yoji Goto, Kazuo Mano, Akihiko Ueda, Yukio Ando, Ikuko Mizuta and Toshiki Mizuno
- Journal Title
  
  Intern. Med.
  
  Volume: 55 Issue: 19 Pages: 2873-2876
- DOI
  10.2169/internalmedicine.55.7123
- NAID
  130005605891
- ISSN
  0918-2918, 1349-7235
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461276
[Journal Article] Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy with a Novel NOTCH3 Cys323Trp Mutation Presenting Border-Zone Infarcts: A Case Report and Literature Review2016
- Author(s)
  Maya Tojima, Satoshi Saito, Yumi Yamamoto, Toshiki Mizuno, Masafumi Ihara, and Hidetoshi Fukuda.
- Journal Title
  
  Journal of Stroke and Cerebrovascular Diseases
  
  Volume: 25 Issue: 8 Pages: 128-130
- DOI
  10.1016/j.jstrokecerebrovasdis.2016.05.013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461276
[Journal Article] Serum Levels of Coenzyme Q10 in Patients with Multiple System Atrophy.2016
- Author(s)
  Kasai T, Tokuda T, Ohmichi T, Ishii R, Tatebe H, Nakagawa M, Mizuno T
- Journal Title
  
  Plos One
  
  Volume: 11 Issue: 1 Pages: e0147574-e0147574
- DOI
  10.1371/journal.pone.0147574
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09319, KAKENHI-PROJECT-15K09322
[Journal Article] Distinct molecular mechanisms of HTRA1 mutants in manifesting heterozygotes with CARASIL.2016
- Author(s)
  Nozaki H, Kato T, Nihonmatsu M, Saito Y, Mizuta I, Noda T, Koike R, Miyazaki K, Kaito M, Ito S, Makino M, Koyama A, Shiga A, Uemura M, Sekine Y, Murakami A, Moritani S, Hara K, Yokoseki A, Kuwano R, Endo N, Momotsu T, Yoshida M, Nishizawa M, Mizuno T, Onodera O
- Journal Title
  
  Neurology
  
  Volume: 86 Issue: 21 Pages: 1-10
- DOI
  10.1212/wnl.0000000000002694
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461276, KAKENHI-PLANNED-26117006, KAKENHI-PROJECT-16H02656
[Journal Article] Very prolonged capsular warning syndrome.2015
- Author(s)
  Makita N, Yamamoto Y, Nagakane Y, Ashida S, Mizuno T.
- Journal Title
  
  J Neurol Sci. 2015
  
  Volume: 352 Issue: 1-2 Pages: 115-116
- DOI
  10.1016/j.jns.2015.03.023
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461276
[Journal Article] 脳卒中臨床の最新の話題　遺伝性脳小血管病（CADASIL,CALASIL)2015
- Author(s)
  向井麻央,水野敏樹
- Journal Title
  
  医学のあゆみ
  
  Volume: 254 Pages: 113-117
- Data Source
  KAKENHI-PROJECT-26461276
[Journal Article] 皮質下性認知症の現代的捉え方　遺伝性脳小血管病からの解析2015
- Author(s)
  水野敏樹
- Journal Title
  
  BRAIN and NERVE
  
  Volume: 67 Pages: 403-412
- Data Source
  KAKENHI-PROJECT-26461276
[Journal Article] TGF-beta1 is associated with the progression of intracranial deep white matter lesions: a pilot study with 5 years of magnetic resonance imaging follow-up.2014
- Author(s)
  Kuriyama N, Mizuno T, Kita M, Yamada K, Ozaki E, Matsumoto S, Takada A, Watanabe A, Kasai T, Nagakane Y, Mitani S, Matsui D, Watanabe I, Takeda K, Nakagawa M, Watanabe Y.
- Journal Title
  
  Neurol Res.
  
  Volume: 36 Issue: 1 Pages: 47-52
- DOI
  10.1179/1743132813y.0000000256
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24590809, KAKENHI-PROJECT-24591302
[Journal Article] Long insular artery infarction: characteristics of a previously unrecognized entity2014
- Author(s)
  Tamura A, Kasai T, Akazawa K, Nagakane Y, Yoshida T, Fujiwara Y, Kuriyama N, Yamada K, Mizuno T, Nakagawa M.
- Journal Title
  
  American Journal of Neuroradiology
  
  Volume: 35 Issue: 3 Pages: 166-471
- DOI
  10.3174/ajnr.a3704
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591302, KAKENHI-PROJECT-24791325
[Journal Article] 脳卒中と遺伝子Update CADASIL2014
- Author(s)
  渡邉　明子、水野敏樹
- Journal Title
  
  分子脳血管病
  
  Volume: 13 Pages: 175-178
- Data Source
  KAKENHI-PROJECT-26461276
[Journal Article] Detection of early neuronal damage in CADASIL patients by q-space MR imaging.2013
- Author(s)
  Yamada K, Sakai K, Akazawa K, Sugimoto N, Nakagawa M, Mizuno T
- Journal Title
  
  Neuroradiology
  
  Volume: 55 Issue: 3 Pages: 283-290
- DOI
  10.1007/s00234-012-1105-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591302, KAKENHI-PROJECT-24791325
[Journal Article] TGF-beta1 is associated with the progression of intracranial deep white matter lesions: a pilot study with 5 years of magnetic resonance imaging follow-up.2013
- Author(s)
  Kuriyama N，Mizuno T, Kita M, Yamada K, Ozaki E, Matsumoto S, Takada A, Watanabe A, Kasai T, Nagakane Y, Mitani S, Matsui D, Watanabe I, Takeda K, Nakagawa M, Watanabe Y.
- Journal Title
  
  Neurol Res.
  
  Volume: 36 Pages: 47-52
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390176
[Journal Article] Intracranial deep white matter lesions (DWLs) are associated with chronic kidney disease (CKD) and cognitive impairment: A 5-year follow-up magnetic resonance imaging (MRI) study.2013
- Author(s)
  Kuriyama N, Mizuno T, Ohshima Y, Yamada K, Ozaki E, Shigeta M, Mitani S, Kondo M, Matsumoto S, Takeda K, Nakagawa M, Watanabe Y.
- Journal Title
  
  Arch Gerontol Geriatr.
  
  Volume: 56 Pages: 55-60
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590809
[Journal Article] 遺伝性脳小血管病　皮質下梗塞と白質脳症を伴う常染色体優性脳動脈症(CADASIL)2013
- Author(s)
  水野敏樹
- Journal Title
  
  日本臨床
  
  Volume: 別冊　神経症候群I Pages: 302-306
- Data Source
  KAKENHI-PROJECT-24591302
[Journal Article] Low vitamin and carotenoid levels are related to cerebral white matter lesions.2013
- Author(s)
  Ohshima Y, Mizuno T, Yamada K, Matsumoto S, Nagakane Y, Kondo M, Kuriyama, Miyazaki T, Takeda K, Nishimura T, Nakagawa M, Ozasa K, Watanabe Y.
- Journal Title
  
  J Nutr health aging
  
  Volume: 17 Pages: 456-460
- DOI
  10.1007/s12603-012-0427-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390176
[Journal Article] Intracranial deep white matter lesions (DWLs) are associated with chronic kidney disease (CKD) and cognitive impairment: A 5-year follow-up magnetic resonance imaging (MRI) study2013
- Author(s)
  N. Kuriyama, T. Mizuno, Y. Ohshima, K. Yamada, E. Ozaki, M. Shigeta, S. Mitani, M. Kondo, S. Matsumoto, K. Takeda, M. Nakagawa, Y. Watanabe
- Journal Title
  
  Arch Gerontol Geriatr
  
  Volume: 56(1) Issue: 1 Pages: 55-60
- DOI
  10.1016/j.archger.2011.11.009
- URL
  http://dx.doi.org/
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591595
[Journal Article] TGF-beta1 is associated with the progression of intracranial deep white matter lesions: a pilot study with 5 years of magnetic resonance imaging follow-up.2013
- Author(s)
  Kuriyama N，Mizuno T, Kita M, Yamada K, Ozaki E, Matsumoto S, Takada A, Watanabe A, Kasai T, Nagakane Y, Mitani S, Matsui D, Watanabe I, Takeda K, Nakagawa M, Watanabe Y.
- Journal Title
  
  Neurol Res.
  
  Volume: 36 Pages: 47-52
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590809
[Journal Article] Intracranial deep white matter lesions (DWLs) are associated with chronic kidney disease (CKD) and cognitive impairment: A 5-year follow-up magnetic resonance imaging (MRI) study.2013
- Author(s)
  Kuriyama N, Mizuno T, Ohshima Y, Yamada K, Ozaki E, Shigeta M, Mitani S, Kondo M, Matsumoto S, Takeda K, Nakagawa M, Watanabe Y.
- Journal Title
  
  Arch Gerontol Geriatr.
  
  Volume: 56(1) Pages: 55-60
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390176
[Journal Article] p62/SQSTM1-dependent autophagy of Lewy body-like α-synuclein inclusions2012
- Author(s)
  Watanabe Y, Tatebe H, Taguchi K, Endo Y, Tokuda T, Mizuno T, Nakagawa M, Tanaka M
- Journal Title
  
  PLoS One
  
  Volume: 7 Issue: 12 Pages: e52868-e52868
- DOI
  10.1371/journal.pone.0052868
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591252, KAKENHI-PROJECT-24591272, KAKENHI-PROJECT-24890197
[Journal Article] Simultaneous impairment of intracranial and peripheral artery vasoreactivity in CADASIL patients.2012
- Author(s)
  Fujiwara Y, Mizuno T, Okuyama C, Nagakane Y, Watanabe-Hosomi A, Kondo M, Kuriyama N, Tokuda T, Matsushima S, Nishimura T, Nakagawa M
- Journal Title
  
  Cerebrovascular Diseases
  
  Volume: 33 Issue: 2 Pages: 128-134
- DOI
  10.1159/000334185
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591252
[Journal Article] p62/SQSTM1-dependent autophagy of Lewy body-likeα-synuclein inclusions2012
- Author(s)
  Watanabe Y、Tatebe H、Taguchi K、Endo Y、Tokuda T、Mizuno T、Nakagawa M、Tanaka M
- Journal Title
  
  PLoS One
  
  Volume: Vol.7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591252
[Journal Article] Knockdown of the Drosophila Fused in Sarcoma (FUS) homologue causes deficient locomotive behavior and shortening of motoneuron terminal branches.2012
- Author(s)
  Sasayama, H., Shimamura, M., Tokuda, T., Azuma, Y., Yoshida, T., Mizuno, T., Nakagawa, M., Fujikake, N., Nagai, Y. and Yamaguchi, M
- Journal Title
  
  PLoS ONE
  
  Volume: 7(6), Issue: 6 Pages: e39483-e39483
- DOI
  10.1371/journal.pone.0039483
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22241052, KAKENHI-PUBLICLY-23013015, KAKENHI-PROJECT-23390237, KAKENHI-PROJECT-23570004, KAKENHI-PROJECT-23591252, KAKENHI-PROJECT-24406030, KAKENHI-PROJECT-24570211, KAKENHI-PROJECT-24591286, KAKENHI-PROJECT-24659438, KAKENHI-PUBLICLY-23110528
[Journal Article] Intracranial deep white matter lesions are associated with chronic kidney disease and cognitive impairment : A 5-year follow-up MRI study2011
- Author(s)
  Kuriyama N, Mizuno T, Kondo M, Nakagawa M, Watanabe Y, et al
- Journal Title
  
  Arch Gerontol Geriatr
  
  Volume: (Epub ahead of print)(Epub ahead of printであり、現時点ではまだ付記されていません)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390176
[Journal Article] 【心と身体の健康最近の話題】認知症の早期発見と予防2010
- Author(s)
  水野敏樹
- Journal Title
  
  京都府立医科大学雑誌
  
  Volume: 119(6) Pages: 425-435
- Data Source
  KAKENHI-PROJECT-22591595
[Journal Article] 認知症と血管性要因2010
- Author(s)
  中川正法,水野敏樹
- Journal Title
  
  老年期認知症研究会誌
  
  Volume: 16 Pages: 80-82
- Data Source
  KAKENHI-PROJECT-22591595
[Journal Article] Evaluation of factors associated with elevated levels of platelet-derived microparticles in the acute phase of cerebral infarction2010
- Author(s)
  Kuriyama N, Nagakane Y, Hosomi A, Ohara T, Kasai T, Harada S, Takeda, K, Yamada K, Ozasa K, Tokuda T, Watanabe Y, Mizuno T, Nakagawa M.
- Journal Title
  
  Clin Appl Thromb Hemost. 16 (1)
  
  Pages: 26-32
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390178
[Journal Article] Predictive markers of blood cytokine and chemokine in recurrent brain infarction2009
- Author(s)
  Kuriyama N, Mizuno T, Kita M, Nagakane Y, Hosomi A, Harada S, Takeda K, OzasaK, Yamada K, Tokuda T, Watanabe Y, Nakagawa M, et al.
- Journal Title
  
  Journal of Interferon & Cytokine Research (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390178
[Journal Article] Evaluation of factors associated with elevated levels of platelet- derived microparticles in the acute phase of cerebral infarction2009
- Author(s)
  Kuriyama N, Ozasa K, Watanabe Y, Mizuno T, Nakagawa M, et al.
- Journal Title
  
  Clinical and Applied Thrombosis/Hemostasis (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390178
[Journal Article] Predictive markers of blood cytokine and chemokine in recurrent brain infarction2009
- Author(s)
  Kuriyama N, Mizuno T, Ozasa K, Watanabe Y, Nakagawa Metal.
- Journal Title
  
  Journal of Interferon & Cytokine Research (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390178
[Journal Article] Quantitative evaluation of cerebrovascular reactivity in brain tissue by a refill kinetic method of transcranial ultrasonic perfusion imaging : a comparison with Doppler sonography2005
- Author(s)
  T.Shiogai, A.Morisaka, N.Takayasu, K.T.Mizuno, et al.
- Journal Title
  
  Acta Neurochir 95(suppl)
  
  Pages: 183-190
- Data Source
  KAKENHI-PROJECT-16590840
[Journal Article] Local tissue anisotropy decreases in cerebellopetal fibers and pyramidal tract in multiple system atrophy.2005
- Author(s)
  Shiga K, Yamada K, Mizuno T, et al.
- Journal Title
  
  Journal of Neurology 252(5)
  
  Pages: 589-596
- Data Source
  KAKENHI-PROJECT-16590840
[Journal Article] Discrepancy between clinical and pathological diagnoses of CBD and PSP2005
- Author(s)
  T.Mizuno, K.Shiga, Y.Nakata et al.
- Journal Title
  
  Journal of Neurology 252(6)
  
  Pages: 687-697
- Data Source
  KAKENHI-PROJECT-16590840
[Journal Article] Autonomic nervous evaluation in the early stages of olivopontocerebellar atrophy.2005
- Author(s)
  N Kuriyama, T Mizuno, I Akio, et al.
- Journal Title
  
  Autonomic Neuroscience : Basic and Clinical 123
  
  Pages: 87-93
- Data Source
  KAKENHI-PROJECT-16590840
[Presentation] 遺伝性・孤発性脳小血管病におけるヒストグラム解析による白質病変の鑑別2024
- Author(s)
  水野敏樹, 福永大幹, 松浦啓, 酒井晃司, 渡邉-細見明子, 向井麻央, 水田依久子, 山田惠, 尾原知行
- Organizer
  厚生労働科学研究　令和5年度治験を目的とした、成人発症白質脳症のレジストリーと評価方法に関する研究班班会議
- Data Source
  KAKENHI-PROJECT-22K07521
[Presentation] Histogram analysis: new methods for diagnosing CADASIL2023
- Author(s)
  Daiki Fukunaga, Tomoyuki Ohara, Hiraku Matsuura, Akiko Watanabe-Hosomi, Ikuko Mizuta, Koji Sakai, Kei Yamada, Toshiki Mizuno
- Organizer
  第64回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-22K07521
[Presentation] Histogram analysis: new methods for diagnosing CADASIL2023
- Author(s)
  Daiki Fukunaga, Tomoyuki Ohara, Hiraku Matsuura, Akiko Watanabe-Hosomi, Ikuko Mizuta, Koji Sakai, Kei Yamada, Toshiki Mizuno
- Organizer
  World Stroke Congress 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07521
[Presentation] NOTCH3陰性CADASIL疑い症例における神経核内封入体病の頻度と画像的特徴2023
- Author(s)
  松浦啓, 水田依久子, 玉井知里, 安田怜, 渡邉-細見明子, 福永大幹, 小泉崇, 向井麻央, 尾原知行, 吉田誠克, 曽根淳, 水野敏樹
- Organizer
  第13回日本脳血管・認知症学会総会
- Data Source
  KAKENHI-PROJECT-22K07521
[Presentation] 高齢者検診における血管性認知機能低下のリスク保有者におけるSDVスコアの有用性2020
- Author(s)
  栗山長門，尾崎悦子，小山晃英，松井大輔，渡邊功，富田仁美，長光玲央，猪原匡史，齊藤聡，丸中良典，武田和夫，高田明浩，赤澤健太郎，山田恵，近藤正樹，水野敏樹，渡邊能行，上原里程．
- Organizer
  第30回日本疫学会総会
- Data Source
  KAKENHI-PROJECT-18H03052
[Presentation] 脳小血管病における認知機能低下のリスク保有者における新規SVDスコアの有用性―高齢者検診における検討．2020
- Author(s)
  栗山長門，猪原匡史，齊藤聡，山田恵，水野敏樹．
- Organizer
  第45回日本脳卒中学会総会
- Data Source
  KAKENHI-PROJECT-18H03052
[Presentation] 高齢者検診における血管性認知機能低下のリスク保有者におけるSDVスコアの有用性．2020
- Author(s)
  栗山長門，尾崎悦子，小山晃英，松井大輔，渡邉功，富田仁美，長光玲央，丸中良典，赤澤健太郎，山田恵，近藤正樹，水野敏樹，渡邊能行，上原里程ら．
- Organizer
  第30回日本疫学会学術総会．2020年2月22日、京都
- Data Source
  KAKENHI-PROJECT-18H03052
[Presentation] Potential Mechanisms of stroke in CADASIL.2018
- Author(s)
  Mizuno T.
- Organizer
  The 9th International Conference of The International Society of Vascular Behavioural and Cognitive Disorders.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09698
[Presentation] Genetic causes of cerebral small vessel disease.2018
- Author(s)
  Mizuno T.
- Organizer
  16th Asian Oceanian Congress of Neurology．
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09698
[Presentation] 晩期発症型アレキサンダー病の発症年齢に関連する遺伝的変異の検討.2018
- Author(s)
  安田怜，吉田誠克，中野正和，佐藤隆一，足立博子，徳田雄市，水田依久子，齋藤光象，松浦　潤，中川正法，田代啓，水野敏樹．
- Organizer
  第59回日本神経学会学術大会．
- Data Source
  KAKENHI-PROJECT-16K09698
[Presentation] Mid-regional pro-adrenomedullin levels are associated with progression of deep white matter lesions in the brain　accompanying cognitive decline.2018
- Author(s)
  Kuriyama N, Koyama T, Ihara M, Mizuno T, Ozaki E, Matsui D, Watanabe I, Kondo M, Tokuda T, Tamura A, Yamada K, Akazawa K,Takeda K, Takada A, Mizuno S, Nakagawa M, Watanabe Y.
- Organizer
  The 21st International Epidemiological Association (IEA) World Congress of Epidemiology (WCE2017).
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08812
[Presentation] Vasoactive mid-regional pro-adrenomedullin is associated with cognitive decline accompanying deep white matter lesions in the brain: a cross-sectional brain MRI study.2018
- Author(s)
  Kuriyama N, Koyama T, Ihara M, Mizuno T, Ozaki E, Matsui D, Watanabe I, Kondo M, Tokuda T, Tamura A, Yamada K, Akazawa K,Takeda K, Takada A, Mizuno S, Nakagawa M, Watanabe Y.
- Organizer
  XXIII World Congress of Neurology.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08812
[Presentation] NEW DIAGNOSTIC CRITERIA FOR CEREBRAL AUTOSOMAL DOMINANT ARTERIOPATHY WITH SUBCORTICAL INFARCTS AND LEUKOCENCEPHALOPATHY IN JAPAN2017
- Author(s)
  T. MizunoI. Mizuta 　A. Watanabe-Hosomi 　T. Koizumi 　M. Mukai 　A. Hamano Y. Tomii 　M. Kondo 　M. Nakagawa 　T. Hirano 　M. Uchino 　O. Onodera H. Tomimoto
- Organizer
  World Congress of Neurology 2107
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461276
[Presentation] Mid-regional pro-adrenomedullin levels are associated with progression of deep white matter lesions in the brain accompanying cognitive decline.2017
- Author(s)
  Kuriyama N, Koyama T, Ihara M, Mizuno T, Ozaki E, Matsui D, Watanabe I, Kondo M, Tokuda T, Tamura A, Yamada K, Akazawa K, Takeda K, Takada A, Mizuno S, Nakagawa M, Watanabe Y.
- Organizer
  The 21st International Epidemiological Association (IEA) World Congress of Epidemiology (WCE2017).
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08812
[Presentation] Vasoactive mid-regional pro-adrenomedullin is associated with cognitive decline accompanying deep white matter lesions in the brain: a cross-sectional brain MRI study.2017
- Author(s)
  Kuriyama N, Koyama T, Ihara M, Mizuno T, Ozaki E, Matsui D, Watanabe I, Kondo M, Tokuda T, Tamura A, Yamada K, Akazawa K, Takeda K, Takada A, Mizuno S, Nakagawa M, Watanabe Y.
- Organizer
  XXIII World Congress of Neurology.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08812
[Presentation] Early-onset parkinsonism in a pedigree with phosphoglycerate kinase deficiency and a heterozygous carrier: Do PGK-1 mutations contribute to vulnerability to parkinsonism?2017
- Author(s)
  Takashi Kasai, Satoshi Sakaue, Ikuko Mizuta, Masaya Suematsu, Shinya Osone, Yumiko Azuma, Toshihiko Imamura, Takahiko Tokuda, Hitoshi Kanno, Omar M. A. El-Agnaf, Masafumi Morimoto, Masanori Nakagawa, Hajime Hosoi, and Toshiki Mizuno
- Organizer
  World Congress of Neurology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09319
[Presentation] キメラNOTCH3導入ショウジョウバエを用いた遺伝性脳小血管病CADASIL病態解明へのアプローチ2017
- Author(s)
  水田依久子, 東裕美子, 吉田英樹, 山口政光, 水野敏樹
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-26461296
[Presentation] Endothelin1による白質脳症の機序2017
- Author(s)
  水野敏樹水田依久子、渡邊明子、向井麻央、小泉崇
- Organizer
  第36回日本認知症学会学術集会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461276
[Presentation] CADASILの発症機序と今後の展開2017
- Author(s)
  水野敏樹
- Organizer
  第49回日本動脈硬化学会総会・学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-26461276
[Presentation] Lesson from the hereditary cerebral small vessel disease2017
- Author(s)
  Toshiki　Mizuno
- Organizer
  international conference of Neurology and brain disorders conference
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461276
[Presentation] 日本人に即したCADASILスケール作成およびその有効性の検討．2016
- Author(s)
  小泉崇　向井麻央，濱野愛，渡邊明子，水田依久子，水野敏樹．
- Organizer
  第7回日本脳血管・認知症学会学術大会
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-26461276
[Presentation] Strategy to elucidate pathogenesis of CADASIL using transgenic Drosophila models of human NOTCH32016
- Author(s)
  Ikuko Mizuta, Yumiko Azuma, Narumi Toda, Hideki Yoshida, Masamitsu Yamaguchi, Toshiki Mizuno
- Organizer
  第57回日本神経学会学術大会
- Place of Presentation
  神戸
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-26461296
[Presentation] A case report of heterozygous Pro285Leu HTRA1 mutation2016
- Author(s)
  T Mizuno , I Mizuta, M Makino, H Nozaki, T Kato, O Onodera
- Organizer
  The 8th Vas-Cog World Conference
- Place of Presentation
  Amsterdam, Netherland
- Year and Date
  2016-10-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461276
[Presentation] CADASILにおける脳血管反応異常とそれに基づく治療戦略2016
- Author(s)
  水野敏樹
- Organizer
  第41回日本脳卒中学会総会
- Place of Presentation
  札幌
- Invited
- Data Source
  KAKENHI-PROJECT-26461276
[Presentation] 遺伝性の血管性認知症ーCADASILとCARASILー2016
- Author(s)
  水野敏樹
- Organizer
  第35回日本認知症学会学術集会
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-26461276
[Presentation] Strategy to elucidate pathogenesis of CADASIL using transgenic Drosophila models of human NOTCH32016
- Author(s)
  Ikuko Mizuta, Yumiko Azuma, Narumi Toda, Hideki Yoshida, Masamitsu Yamaguchi, Toshiki Mizuno
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-12-01
- Data Source
  KAKENHI-PROJECT-26461296
[Presentation] CADASILはどこまで解明されたか2016
- Author(s)
  水野敏樹
- Organizer
  第57回日本神経学会学術大会
- Place of Presentation
  神戸
- Year and Date
  2016-05-18
- Invited
- Data Source
  KAKENHI-PROJECT-26461276
[Presentation] Consideration of Issues Related to Pre-and Post-Genetic Test for CADASIL2015
- Author(s)
  Ikuko Mizuta, Mao Mukai, Akiko Watanabe, Ai Hamano, Tomoyuki Ohara, Tomokatsu Yoshida, Toshiki Mizuno
- Organizer
  The 7th Vas-Cog World Conference
- Place of Presentation
  Tokyo
- Year and Date
  2015-09-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461276
[Presentation] A Case Report of CADASIL with a Homozygous NOTCH3 Mutation Arg544Cys2015
- Author(s)
  Mao Mukai, Daisuke N,Yukie Kushimura,Yu-ichi Noto, Tomoyuki Ohara, Ikuko Mizuta, Toshiki Mizuno.
- Organizer
  The 7th Vas-Cog World Conference
- Place of Presentation
  Tokyo
- Year and Date
  2015-09-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461276
[Presentation] 認知症を伴うCADASIL症例のスクリーニング認知機能検査にみられる特徴2015
- Author(s)
  手塚陽子, 近藤正樹,水野敏樹
- Organizer
  第6回日本脳血管・認知症学会学術大会
- Place of Presentation
  東京
- Year and Date
  2015-09-19
- Data Source
  KAKENHI-PROJECT-26461276
[Presentation] Validation of Japanese Diagnostic Criteria for Cerebral Autosomal Dominant Arteriopathy with Subcorical Infarcts and Leukocencephalopathy2015
- Author(s)
  Toshiki Mizuno, Ikuko Mizuta, Akiko Watanabe, Ai Hamano, Mao Mukai, Masaki Kondo, Masanori Nakagawa, Hidekazu Tomimoto, Makoto Uchino, Osamu Onodera.
- Organizer
  The 7th Vas-Cog World Conference
- Place of Presentation
  Tokyo
- Year and Date
  2015-09-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461276
[Presentation] 認知機能低下を伴う大脳白質病変及びその進行における活性化血小板機能の解析2014
- Author(s)
  栗山長門，水野敏樹，安池博美，松野浩之，河下映里，田邑愛子，尾崎悦子，松井大輔，渡邉功，近藤正樹，徳田隆彦，大島洋一，吉田誠克，村西学，赤澤健太郎，高田明浩，武田和夫，山田惠，中川正法，渡邊能行
- Organizer
  第55回日本神経学会
- Place of Presentation
  福岡市
- Year and Date
  2014-05-22
- Data Source
  KAKENHI-PROJECT-23390176
[Presentation] CADASIL 患者における活性化血小板マーカー（PAC-1, CD62p）の検討2014
- Author(s)
  藤並　潤、大原　亮、森井芙貴子、水野　敏樹
- Organizer
  第5回日本血管性認知障害研究会
- Place of Presentation
  京都
- Year and Date
  2014-08-23
- Data Source
  KAKENHI-PROJECT-26461276
[Presentation] CADASILのNOTCH3遺伝子変異分布と臨床像との関連性について2014
- Author(s)
  水田依久子，渡邉明子，濱野愛，中川正法，水野敏樹．
- Organizer
  第5回日本血管性認知障害研究会
- Place of Presentation
  京都
- Year and Date
  2014-08-23
- Data Source
  KAKENHI-PROJECT-26461276
[Presentation] 遺伝性血管性認知症からみた認知症の分子機構2014
- Author(s)
  水野敏樹
- Organizer
  第33回日本認知症学会学術集会
- Place of Presentation
  横浜
- Year and Date
  2014-11-29
- Invited
- Data Source
  KAKENHI-PROJECT-24591302
[Presentation] 認知機能低下を伴う大脳白質病変及びその進行における活性化血小板機能の解析．2014
- Author(s)
  栗山長門，水野敏樹，安池博美，松野浩之，河下映里，田邑愛子，尾崎悦子，松井大輔，渡邉功，近藤正樹，徳田隆彦，大島洋一，吉田誠克，村西学，赤澤健太郎，高田明浩，武田和夫，山田惠，中川正法，渡邊能行．
- Organizer
  第55回日本神経学会
- Place of Presentation
  福岡
- Year and Date
  2014-05-22
- Data Source
  KAKENHI-PROJECT-24590809
[Presentation] α-Synuclein is present as a monomer in the biological fluids2013
- Author(s)
  Tatebe H, Tokuda T, Ishi R, Watanabe Y, Kasai T, Taguchi K, Mizuta I, Tanaka M, Mizuno T
- Organizer
  The 20th World Congress on Parkinson’s Disease and Related Disorders
- Place of Presentation
  Geneva, Switzerland
- Data Source
  KAKENHI-PROJECT-23591252
[Presentation] Interference from heterophilic antibodies in A-Syn ELISA2013
- Author(s)
  Ishii R、Tokuda T、Tatebe H、Kasai T、Mizuno T、Nakagawa M
- Organizer
  The 20th World Congress on Parkinson's Disease and Related Disorders
- Place of Presentation
  Geneva、Switzerland
- Year and Date
  2013-12-11
- Data Source
  KAKENHI-PROJECT-23591252
[Presentation] α-Synuclein is present as a monomer in the biological fluids2013
- Author(s)
  Tatebe H、Tokuda T、Ishi R、Watanabe Y、Kasai T、Taguchi K、Mizuta I、Tanaka M、Mizuno T
- Organizer
  The 20th World Congress on Parkinson's Disease and Related Disorders
- Place of Presentation
  Geneva、Switzerland
- Year and Date
  2013-12-11
- Data Source
  KAKENHI-PROJECT-23591252
[Presentation] Interference from heterophilic antibodies in A-Syn ELISA2013
- Author(s)
  Ishii R, Tokuda T, Tatebe H, Kasai T, Mizuno T, Nakagawa M
- Organizer
  The 20th World Congress on Parkinson’s Disease and Related Disorders
- Place of Presentation
  Geneva, Switzerland
- Data Source
  KAKENHI-PROJECT-23591252
[Presentation] Q space imagingによるCADASILの解析2012
- Author(s)
  水野敏樹　山田惠　酒井晃二　冨井康宏　牧野雅弘　中川正法
- Organizer
  第37回日本脳卒中学会総会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24591302
[Presentation] 高血圧モデルラットにおける TGFβ1 発現2011
- Author(s)
  水野敏樹、王佳虹、鳥羽裕恵、中野亜里沙、東條千里、野田和揮、小原幸、中川正法、中田徹男
- Organizer
  第52神経病理学会総会学術研究会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-22591595
[Presentation] 深部白質病変進行におけるTGF-β1および慢性腎臓病の関与2011
- Author(s)
  栗山長門, 水野敏樹, 渡邊能行, 中川正法, 他
- Organizer
  第36回日本脳卒中学会総会
- Place of Presentation
  京都
- Year and Date
  2011-07-31
- Data Source
  KAKENHI-PROJECT-23390176
[Presentation] 高血圧モデルラットにおけるTGFβ1発現2011
- Author(s)
  水野敏樹, ら
- Organizer
  第52神経病理学会総会学術研究会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-22591595
[Presentation] 深部白質病変進行のリスク因子としてのTGF-B1値の検討2010
- Author(s)
  栗山長門、水野敏樹, ら
- Organizer
  第35回日本脳卒中学会総会
- Place of Presentation
  盛岡
- Data Source
  KAKENHI-PROJECT-22591595
[Presentation] 深部白質病変進行のリスク因子としてのTGF-β1 値の検討2010
- Author(s)
  栗山長門、水野敏樹、笠井高士、田邑愛子、渡邉明子、山田恵、渡邊能行、中川正法
- Organizer
  第35回日本脳卒中学会総会
- Place of Presentation
  盛岡
- Data Source
  KAKENHI-PROJECT-22591595
[Presentation] Longitudinal study of risk factors for intracranial deep white matter lesions2010
- Author(s)
  Kuriyama N, Mizuno T, Mitani S, Ozaki E, Shigeta M, Matsumoto S, Takeda K, Yamada K, Nakagawa M, Watanabe Y
- Organizer
  The Joint Scientific Meeting of IEA (International Epidemiological Association) Western Pacific Region and Japan Epidemiological Association
- Place of Presentation
  Saitama
- Year and Date
  2010-01-09
- Data Source
  KAKENHI-PROJECT-19390178
[Presentation] 脳虚血・白質病変の進行に関与する危険因子の前向き縦断的検討2009
- Author(s)
  栗山長門, 水野敏樹, 大島洋一, 笠井高士, 山田丈弘, 松本早苗, 武田和夫, 山田恵, 中川正法, 渡邊能行, 他
- Organizer
  第34回日本脳卒中学会総会
- Year and Date
  2009-03-21
- Data Source
  KAKENHI-PROJECT-19390178
[Presentation] Neurosin によるα-synuclein 分解の解析2009
- Author(s)
  建部陽嗣, 渡邊義久, 笠井高士, 徳田隆彦, 水野敏樹, 田中雅樹, 中川正法
- Organizer
  日本神経科学大会(第32回)
- Place of Presentation
  名古屋
- Year and Date
  2009-09-18
- Data Source
  KAKENHI-PROJECT-20591007
[Presentation] α-synuclein 分解酵素であるneurosin の細胞内動態の検討2009
- Author(s)
  笠井高士, 建部陽嗣, 徳田隆彦, 石神紀子, 水野敏樹, 中川正法, 渡邊義久, 田中雅樹
- Organizer
  日本神経学会総会(第50回)
- Place of Presentation
  仙台
- Year and Date
  2009-05-20
- Data Source
  KAKENHI-PROJECT-20591007
[Presentation] 脳虚血・白質病変の進行に関与する危険因子の前向き縦断的検討2008
- Author(s)
  栗山, 水野, 中川, 渡邊ら
- Organizer
  第34回日本脳卒中学会総会
- Place of Presentation
  松江市、島根
- Year and Date
  2008-03-21
- Data Source
  KAKENHI-PROJECT-19390178
[Presentation] 動脈硬化および生活習慣の認知機能検査への影響について2007
- Author(s)
  水野敏樹, 近藤正樹, 栗山長門, 原田早苗, 武田和夫, 渡邊能行, 中川正法
- Organizer
  第49回日本老年医学会
- Place of Presentation
  札幌
- Year and Date
  2007-06-22
- Data Source
  KAKENHI-PROJECT-19390178
[Presentation] 生活習慣・動脈硬化の認知機能検査に対する関与2007
- Author(s)
  水野敏樹, 近藤正樹, 栗山長門, 三谷智子, 尾崎悦子, 原田早苗, 武田和夫, 渡邊能行, 中川正法
- Organizer
  第48回日本神経学会総会
- Place of Presentation
  名古屋
- Year and Date
  2007-05-18
- Data Source
  KAKENHI-PROJECT-19390178
[Presentation] 頸部動脈wave intensity (WI) 解析の脳神経超音波への応用
- Author(s)
  1.塩貝敏之，八木美苑，山本真佑実，有馬有香，小山真理，前島　亨，笠井高士，水野敏樹，中川正法
- Organizer
  第33回日本脳神経超音波学会総会
- Place of Presentation
  岩手
- Year and Date
  2014-06-13 – 2014-06-14
- Data Source
  KAKENHI-PROJECT-24591302
[Presentation] 塩酸ロメリジンによるCADASIL患者における脳梗塞発症に対する予防効果
- Author(s)
  水野敏樹，濱野　愛，渡邉明子，水田依久子，近藤正樹，中川正法
- Organizer
  第32回日本神経治療学会総会．2014年11月20-22日；東京
- Place of Presentation
  東京
- Year and Date
  2014-11-20 – 2014-11-22
- Data Source
  KAKENHI-PROJECT-26461276
[Presentation] 水痘再感染による水痘帯状疱疹ウイルス髄膜炎の一例
- Author(s)
  小島雄太，徳田直輝，中川有夏，中井章淳，能登祐一，村西　学，笠井高士，中川正法，水野敏樹
- Organizer
  第19回日本神経感染症学会総会
- Place of Presentation
  金沢
- Year and Date
  2014-09-04 – 2014-09-06
- Data Source
  KAKENHI-PROJECT-26461276

1. YAMADA Kei (80315960)

# of Collaborated Projects: 8 results

# of Collaborated Products: 26 results
2. KONDOU Masaki (20315964)

# of Collaborated Projects: 5 results

# of Collaborated Products: 14 results
3. KURIYAMA Nagato (60405264)

# of Collaborated Projects: 5 results

# of Collaborated Products: 29 results
4. WATANABE Yoshiyuki (00191809)

# of Collaborated Projects: 5 results

# of Collaborated Products: 28 results
5. NAKAGAWA Masanori (50198040)

# of Collaborated Projects: 5 results

# of Collaborated Products: 22 results
6. OZAKI Etsuko (00438219)

# of Collaborated Projects: 5 results

# of Collaborated Products: 18 results
7. Mizuta Ikuko (80397760)

# of Collaborated Projects: 4 results

# of Collaborated Products: 18 results
8. TOKUDA Takahiko (80242692)

# of Collaborated Projects: 3 results

# of Collaborated Products: 16 results
9. WATANABE Yoshihisa (50363990)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
10. KASAI Takashi (70516062)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
11. MAKINO Masahiro (80271162)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
12. NAKAJIMA Kenji (00237265)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
13. Watanabe Isao (10636525)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
14. Matsui Daisuke (20613566)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
15. Toyama Teruhide (40711362)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
16. 酒井晃二 (20379027)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
17. MITANI Satoko (90423053)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
18. NAKATA Tetsuo (30237292)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
19. HASHIMOTO Tamotsu (00237942)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. FUKUYAMA Ryuichi (60199271)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. YAMAGUCHI Nozomi (40079752)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. TANAKA AKIHIRO (10733503)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
23. Yoshida Tomokatsu (90457987)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
24. 小笹晃太郎 (20204191)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
25. 田中雅樹 (80264753)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 大原亮 (80636986)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
27. 山口政光 (00182460)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
28. 大島洋一 (50516060)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. 上原里程 (90276999)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
30. 渡辺明子 (90828881)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. 佐々木真理 (80205864)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. 布施昇男 (10302134)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. 尾原知行 (20616388)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
34. Mukai Mao

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
35. HIRANO Teruyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
36. YOSHIDA Hideki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Mizuno Toshiki 水野 敏樹

MIZUNO Toshiki 水野 敏樹

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analysisis about the develpoment of cerebral white matter lesion by fractal geometryPrincipal Investigator

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Pathomechanism of cerebral small vessel disease due to disturbance of transendocytosisPrincipal Investigator

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Pathomechanism of cerebral small vessel induced by TGFβ1 signallingPrincipal Investigator

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Mizuno Toshiki 水野敏樹

MIZUNO Toshiki 水野敏樹