HARUKI Mitsuru 春木満

… Alternative Names

春木満ハルキミツル

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Researcher Number	30273593
Other IDs
Affiliation (Current)	2025: 日本大学, 工学部, 教授
Affiliation (based on the past Project Information) *help	2017 – 2019: 日本大学, 工学部, 教授 2011 – 2013: 日本大学, 工学部, 教授 2005 – 2006: 日本大学, 工学部, 助教授 2002 – 2003: 日本大学, 工学部, 助教授 2000 – 2001: 大阪大学, 大学院・工学研究科, 助手 1998: 大阪大学, 大学院・工学研究科, 助手
Review Section/Research Field	Principal Investigator 生物・生体工学 / Chemical biology / Biofunction/Bioprocess / Living organism molecular science / Biological Sciences Except Principal Investigator Science and Engineering
Keywords	Principal Investigator Lysozyme / BglII / RNase A / 酵素阻害剤 / ペプチドライブラリー / モレキュラービーコン / RNA構造変化 / ハイスループットスクリーニング / 薬剤スクリーニング / RNA検出プローブ … More / RNA発現解析 / DNA/RNAヘテロ二重鎖 / RNase H / Thermostability / Ribonuclease HI / Pepsin / Refolding / Molecularly imprinted polymer / 蛋白質耐熱化 / リボヌクレアーゼHI / ペプシン / リゾチーム / 組換え蛋白質生産 / リフォールディング / 分子インプリント法 / DNA ligase / alkaline phosphatase / psychrophilic enzyme / heat-labile enzyme / psychrotroph / recombinant DNA experiment / グリーン化 / Bg1II / DNAリガーゼ / アルカリフォスファターゼ / 低温活性酵素 / 熱失活性酵素 / 低温菌 / 組換えDNA実験 / コンビナトリアルライブラリー / ＤＮＡタグ / 合成レセプター / ペプチド / ３本鎖ＤＮＡ / コンビナトリアル化学 / ハイブリッド分子 / アフィニティセレクション / ファージディスプレイ / RNAライブラリー / リボヌクレアーゼH / 逆転写酵素 / エイズ治療薬 … More Except Principal Investigator ワンポット反応系 / 生体分子 / 進化 / 適応度地形 / タンパク工学 / 統計力学 / モンテカルロ法 / ウェットGA / 進化計算 / ナチュラルコンピューティング / 最適化 / アミノアシル化tRNA合成酵素 / 試験管ウィルス / シミュレーション / 分子進化 / 統計物理 / 遺伝的アルゴリズム / DNAコンピューティング Less

Development of amplificative detection of mRNA using RNase H and its application for drug screeningPrincipal Investigator
- Principal Investigator
  
  HARUKI Mitsuru
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical biology
- Research Institution
  Nihon University
Development of a novel combinatorial synthetic receptor library using triple strand DNAPrincipal Investigator
- Principal Investigator
  
  HARUKI Mitsuru
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Living organism molecular science
- Research Institution
  Nihon University
Development of molecularly imprinted polymer-assisted refolding and stabilization systemPrincipal Investigator
- Principal Investigator
  
  HARUKI Mitsuru
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biofunction/Bioprocess
- Research Institution
  Nihon University
ナチュラルコンピューティングの分子実現とその設計論
- Principal Investigator
  
  山村雅幸
- Project Period (FY)
  2002 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  Tokyo Institute of Technology
Development of heat-labile and psychrophilic enzymes for clean and efficient recombinant DNA experimentPrincipal Investigator
- Principal Investigator
  
  HARUKI Mitsuru
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  生物・生体工学
- Research Institution
  Nihon University
ペプチドライブラリーを用いて選択された分子の連結による強力な阻害剤の作成Principal Investigator
- Principal Investigator
  
  春木満
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  生物・生体工学
- Research Institution
  Osaka University
ペプチドおよびRNAライブラリーを用いたリボヌクレアーゼH活性阻害剤の開発Principal Investigator
- Principal Investigator
  
  春木満
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University

All 2018 2017 2014 2006

All Journal Article Presentation

[Journal Article] Biofilm formation by a Bacillus subtilis strain that produces gamma-polyglutamate2006
- Author(s)
  Morikawa, M., Kagihiro, S., Haruki, M., Takano, K., Branda, S., Kolter, R., Kanaya, S.
- Journal Title
  
  Microbiology 152
  
  Pages: 2801-2807
- Data Source
  KAKENHI-PROJECT-14085203
[Journal Article] Stabilization of E. coli Ribonuclease HI by the ‘stability profile of mutant protein' (SPMP)-inspired random and non-random mutagenesis.2006
- Author(s)
  Haruki, M., Saito, Y., Ota, M., Nishikawa, K., Kanaya, S.
- Journal Title
  
  J.Biotechnol (掲載決定)
- Data Source
  KAKENHI-PROJECT-14085203
[Journal Article] Gene cloning and in vivo characterization of a dibenzothiophene dioxygenase from Xanthobacter polyaromaticivorans.2006
- Author(s)
  Hirano S., Haruki M., Takano K., Imanaka T., Morikawa M., Kanaya S.
- Journal Title
  
  Appl Microbiol Biotechnol 69
  
  Pages: 672-681
- Data Source
  KAKENHI-PROJECT-14085203
[Journal Article] A Hyperthermophilic Protein Acquires Function at the Cost of Stability2006
- Author(s)
  Mukaiyama, A., Haruki, M., Ota, M., Koga, Y., Takano, K., Kanay, a S.
- Journal Title
  
  Biochemistry 45
  
  Pages: 12673-12679
- Data Source
  KAKENHI-PROJECT-14085203
[Presentation] Amplification of RNA signal by iterated target-induced cleavage of fluorescent probes by intracellular RNase H activity2018
- Author(s)
  藤原諒太，平野展孝，春木満
- Organizer
  平成30年度化学系学協会東北大会
- Data Source
  KAKENHI-PROJECT-17K01965
[Presentation] Detection of macrophage cells by RNase H activity-dependent activatable florescence probe2017
- Author(s)
  今泉梓，木原慶彦，市川司，根本修克，平野展孝，春木満
- Organizer
  平成29年度化学系学協会東北大会
- Data Source
  KAKENHI-PROJECT-17K01965
[Presentation] ３本鎖ＤＮＡを利用したコンビナトリアル合成レセプターライブラリーの作成2014
- Author(s)
  春木　満，緑川尚人，岡部諭典，平野展孝
- Organizer
  平成26年度化学系学協会東北大会
- Place of Presentation
  山形大学米沢キャンパス
- Data Source
  KAKENHI-PROJECT-23510264
[Presentation] ペプチドライブラリーを用いたNF-κBおよびp38 MAPK結合ペプチドの探索2014
- Author(s)
  春木満,木原慶彦,堀篭和人,安達優太,平野展孝
- Organizer
  第66回日本生物工学会大会
- Place of Presentation
  札幌(発表予定)
- Data Source
  KAKENHI-PROJECT-23510264
[Presentation] 3本鎖DNAを利用したコンビナトリアル合成レセプターライブラリーの作成2014
- Author(s)
  春木満,緑川尚人,岡部諭典,平野展孝
- Organizer
  平成26年度化学系学協会東北大会
- Place of Presentation
  山形大学米沢キャンパス(発表予定)
- Data Source
  KAKENHI-PROJECT-23510264

1. MORIKAWA Masaaki (20230104)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 山村雅幸 (00220442)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 樺島祥介 (80260652)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 木賀大介 (30376587)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 伏見譲 (80011641)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 染谷博司 (00333518)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 新田克巳 (60293073)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 太田元規 (40290895)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. 喜多一 (20195241)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 井上真郷 (70376953)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 坂本健作 (50240685)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

HARUKI Mitsuru 春木 満

春木 満 ハルキ ミツル

Research Projects

Research Products

Co-Researchers

Development of amplificative detection of mRNA using RNase H and its application for drug screeningPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of a novel combinatorial synthetic receptor library using triple strand DNAPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of molecularly imprinted polymer-assisted refolding and stabilization systemPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ナチュラルコンピューティングの分子実現とその設計論

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of heat-labile and psychrophilic enzymes for clean and efficient recombinant DNA experimentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ペプチドライブラリーを用いて選択された分子の連結による強力な阻害剤の作成Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ペプチドおよびRNAライブラリーを用いたリボヌクレアーゼH活性阻害剤の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Biofilm formation by a Bacillus subtilis strain that produces gamma-polyglutamate2006

Author(s)

Journal Title

Data Source

[Journal Article] Stabilization of E. coli Ribonuclease HI by the ‘stability profile of mutant protein' (SPMP)-inspired random and non-random mutagenesis.2006

Author(s)

Journal Title

Data Source

[Journal Article] Gene cloning and in vivo characterization of a dibenzothiophene dioxygenase from Xanthobacter polyaromaticivorans.2006

Author(s)

Journal Title

Data Source

[Journal Article] A Hyperthermophilic Protein Acquires Function at the Cost of Stability2006

Author(s)

Journal Title

Data Source

[Presentation] Amplification of RNA signal by iterated target-induced cleavage of fluorescent probes by intracellular RNase H activity2018

Author(s)

Organizer

Data Source

[Presentation] Detection of macrophage cells by RNase H activity-dependent activatable florescence probe2017

Author(s)

Organizer

Data Source

[Presentation] ３本鎖ＤＮＡを利用したコンビナトリアル合成レセプターライブラリーの作成2014

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] ペプチドライブラリーを用いたNF-κBおよびp38 MAPK結合ペプチドの探索2014

Author(s)

Organizer

Place of Presentation

HARUKI Mitsuru 春木満

春木満ハルキミツル