MIZUNO Takeshi 水野武

… Alternative Names

水野武ミズノタケシ

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Researcher Number	30281629
Affiliation (Current)	2025: 国立研究開発法人理化学研究所, 生命機能科学研究センター, 専任研究員
Affiliation (based on the past Project Information) *help	2015 – 2016: 国立研究開発法人理化学研究所, 今本細胞核機能研究室, 専任研究員 2007 – 2014: 独立行政法人理化学研究所, 今本細胞核機能研究室, 専任研究員 2009: 理化学研究所, 今本細胞核機能, 専任研究員 2006: RIKEN, Cellular Dynamics Laboratory, Senior Research Scientist, 今本細胞核機能研究室, 先任研究員 2005: 独立行政法人理化学研究所, 花岡細胞生理学研究室, 先任研究員 … More 2002: 理化学研究所, 細胞生理学研究室, 先任研究員 2000 – 2001: 理化学研究所, 細胞生理学研究室, 研究員 1999: 理化学研究所, 細胞生理研究室, 研究員 1998: 理化学研究所, 細胞生理学研究室, 研究員 1996 – 1997: 理化学研究所, 細胞生理学研究室, 基礎科学特別研究員 Less
Review Section/Research Field	Principal Investigator Functional biochemistry / Biological Sciences / Molecular biology / Cell biology Except Principal Investigator Biological Sciences
Keywords	Principal Investigator DNAポリメラーゼα / DNA複製 / 染色体複製 / 複製前複合体 / Cdt1 / DNAポリメラーゼ / プライマーゼ / ORC1 / タンパク質分解 / tsFT20 … More / HSP90 / 核内タンパク質分解 / 温度感受性変異体 / テロメア / pot1 / geminin / 複製フォーク / pre-replicative complex / DNA結合タンパク質 / 複製開始因子 / Mcm / クロマチン / DNAポリメラーゼε / Cdc45 / 酵母two-hybrid法 / α型DNAポリメラーゼ / DNA複製開始機構 / cDNA発現系 / 核移行シグナル / HP1alpha / cell cycle / chromatin / Bah domain / phosphorylation / origin recognition complex / 組換えタンパク質 / 酵母two-hybrid / Mcm2-7 / 複合前複合体 / HP1 / IORC1 / Pre-RC / ORC / HP1alph / 細胞周期 / BAHドメイン / リン酸化 / ORC複合体 / プロテアソーム / novobiocin / HSP９０ / 核内品質管理 / NIH3t3細胞 / 塩化コバルト / 品質管理 / CHIP / 核内変性タンパク質分解 / ノボビオシン / 核内タンパク質品質管理 / ラギング鎖合成 / シェルタリン / 細胞核 / 哺乳類細胞核 / Novobiocin / 温度感受性変異体細胞 / 哺乳類細胞品質管理 / タンパク質品質管理 / 細胞ストレス / ゲノム恒常性 / noboviocine / 核内品質管理機構 / 染色体末端 / 天然変性タンパク質 / 複製工場 / デヒドロアルテヌシン / ポリメラーゼα特異的阻害剤 / MCM10 / DNAポリメローゼε / DNAポリメローゼα / 複製装置複合体 / genimin / Mcm10 / SAP18 / replication factory / replication foci / DNAポリメラーゼδ / 染色体複製機構 / dehydroaltenusin / α型ポリメラーゼ特異的阻害剤 / バキュロウイルス発現系 / 亜鉛フィンガードメイン / 一過性過剰発現 / co-transfection / 蛋白質間相互作用 / プライマーゼ複合体 / DNAポリメラーゼ_α … More Except Principal Investigator DNA複製 / 染色体 / 遺伝子 / ゲノム / 分子生物学 / TRF2 / 染色体不安定性 / テロメア / タンパク質分解制御 / ORC / 複製チェックポイント / ATR / CDC6 / CRL4ユビキチンリガーゼ / クロマチンリモデリング / SNF2H / Cdt1 / 細胞周期制御 / 染色体安定性 / クロマチン / 細胞周期 / 染色体DNA複製 Less

Molecular mechanism of mammalian nuclear protein quality controlPrincipal Investigator
- Principal Investigator
  
  Mizuno Takeshi
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cell biology
- Research Institution
  Institute of Physical and Chemical Research
Molecular mechanism of assembly and control of mammalian replication factoriesPrincipal Investigator
- Principal Investigator
  
  MIZUNO Takeshi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Molecular biology
- Research Institution
  The Institute of Physical and Chemical Research
Molecular mechanisms for pre-replication complexes assembly and its implication in chromosomal stability in mammalian cells
- Principal Investigator
  
  FUJITA Masatoshi
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
Studies of molecular mechanism on assembly of mammalian pre-replicative complex and replication apparatusPrincipal Investigator
- Principal Investigator
  
  MIZUNO Takeshi
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Molecular biology
- Research Institution
  RIKEN
高等真核生物の複製関連因子の探索とinsitu核内再構築Principal Investigator
- Principal Investigator
  
  水野武
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The Institute of Physical and Chemical Research
高等真核生物の新規DNA複製因子の探索とin situ核内再構築Principal Investigator
- Principal Investigator
  
  水野武
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  The Institute of Physical and Chemical Research
哺乳類細胞の複製前クロマチン上に形成されるDNA複製装置複合体の分子構築Principal Investigator
- Principal Investigator
  
  水野武
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  The Institute of Physical and Chemical Research
高等真核生物の複製関連因子の探索とin situ核内再構築Principal Investigator
- Principal Investigator
  
  水野武
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  The Institute of Physical and Chemical Research
哺乳類細胞のDNA複製開始機構の再構成:DNAポリメラーゼαを中心としてPrincipal Investigator
- Principal Investigator
  
  水野武
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Functional biochemistry
- Research Institution
  The Institute of Physical and Chemical Research
マウスのDNAポリメラーゼα/プライマーゼ複合体を用いたDNA複製開始機構の解明Principal Investigator
- Principal Investigator
  
  水野武
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Functional biochemistry
- Research Institution
  The Institute of Physical and Chemical Research
マウスのDNAポリメラーゼ_α/プライマーゼ複合体を用いたDNA複製開始機構の解明Principal Investigator
- Principal Investigator
  
  水野武
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Functional biochemistry
- Research Institution
  The Institute of Physical and Chemical Research

All 2016 2015 2012 2011 2010 2009 2008 2005 Other

All Journal Article Presentation Book

[Book] Quality Control of DNA Polymerase α, Fundamental Aspects of DNA Replication, Jelena Kusic-Tisma (Ed.), ISBN: 978-953-307-259-32011
- Author(s)
  Mizuno T., Izumi M., and Eichinger, C. S.
- Publisher
  InTech
- Data Source
  KAKENHI-PROJECT-22570178
[Book] Effect of a specific mammalian DNA polymerase α inhibitor, dehydroaltenusin, on DNA replication in cultured cells. pp67-111, DNA Replication and Mutation, Raymond P. Leitner (Ed.) ISBN 978-1-61324-490-62011
- Author(s)
  Mizuno, T., Kuriyama, I., Takemura, M., Sakaguchi, K., Sugawara, F., Yoshida, H., Mizushina, Y.
- Publisher
  Nova publisher
- Data Source
  KAKENHI-PROJECT-22570178
[Book] Fundamental Aspects of DNA Replication2011
- Author(s)
  T.Mizuno, M.Izumi, C.S.Eichinger
- Publisher
  In tech ISBN 978-953-307-259-3
- Data Source
  KAKENHI-PROJECT-22570178
[Journal Article] Direct observation method of individual single-stranded DNA molecules using fluorescent replication protein A2011
- Author(s)
  Oshige M, Kawasaki S, Takano H, Yamaguchi K, Kurita H, Mizuno T, Matsuura S, Mizuno A, Katsura S.
- Journal Title
  
  Journal Fluorescence
  
  Volume: 21(3) Issue: 3 Pages: 1189-1194
- DOI
  10.1007/s10895-010-0797-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570178, KAKENHI-PROJECT-22760207
[Journal Article] Cyclin A-Cdk1 regulates the origin firing program in mammalian cells.2009
- Author(s)
  Katsuno Y, Suzuki A, Sugimura K, Okumura K, Zineldeen DH, Shimada M, Niida H, Mizuno T, Hanaoka F, Nakanishi M.
- Journal Title
  
  P r o c. N a t l. A c a d. S c i. U S A 106
  
  Pages: 3184-3189
- Data Source
  KAKENHI-PROJECT-17080013
[Journal Article] Coenzyme Q10 as a potent compound that inhibits Cdt1-geminin interaction.2008
- Author(s)
  Mizushina Y, Takeuchi T, Takakusagi Y, Yonezawa Y, Mizuno T, Yanagi K, Imamoto N, Sugawara F, Sakaguchi K, Yoshida H, Fujita M.
- Journal Title
  
  B i o c h i m. B i o p h y s. A c t a. 1780
  
  Pages: 203-213
- Data Source
  KAKENHI-PROJECT-17080013
[Journal Article] Caenorhabditis elegans geminin homologue participates in cell cycle regulation and germ line development2005
- Author(s)
  K.Yanagi, T.Mizuno, 他7名
- Journal Title
  
  The Journal of Biological Chmeistry 280・20
  
  Pages: 19689-19694
- Data Source
  KAKENHI-PROJECT-17570149
[Journal Article] Novel splicing variant of mouse Orc1 is deficient in nuclear transolocation and resistant for proteasome-mediated degradation2005
- Author(s)
  Y.Miyake, T.Mizuno, K.Yanagi, F.Hanaoka
- Journal Title
  
  The Journal of Biological Chmeistry 280・13
  
  Pages: 12643-12652
- Data Source
  KAKENHI-PROJECT-17570149
[Journal Article] Alterations of DNA and chromatin structures at telomeres, and genetic instability in mouse cells defective in DNA polymerase α2005
- Author(s)
  M.Nakamura, A.Nabetani, T.Mizuno, F.Hanaoka, F.Ishikawa.
- Journal Title
  
  Molecular and Cellular Biology 25・24
  
  Pages: 11073-11088
- Data Source
  KAKENHI-PROJECT-17570149
[Journal Article] Structure and mutagenesis studies of the C-terminal region of licensing factor Cdt1 enable the identification of key residues for binding to replicative helicase MCM proteins J.
- Author(s)
  J. -G. Jee, Mizuno T, Kamada K, Tochio H, Chiba Y, Yanagi K, Yasuda G, Hiroaki H, Hanaoka F, Shirakawa M.
- Journal Title
  
  B i o l. C h e m.
- Data Source
  KAKENHI-PROJECT-17080013
[Presentation] Interaction between mouse telomere binding protein Pot1a and Pot1b and DNA polymerase alpha-primase2016
- Author(s)
  Takeshi Mizuno, Yurika Kobayashi, Kenta Shoji, Sae Miyazawa, Fumio Hanaoka, Naoko Imamoto, Hidetaka Torigoe
- Organizer
  10th 3R International Symposium
- Place of Presentation
  松江アーバンホテル、島根県、松江市
- Year and Date
  2016-11-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25440097
[Presentation] 哺乳類細胞核内のタンパク質品質管理機構の解明2015
- Author(s)
  水野　武，石田竜次，下仲基之、花岡文雄、今本尚子
- Organizer
  第６７回日本細胞生物学会大会
- Place of Presentation
  タワーホール船堀（東京都江戸川区）
- Year and Date
  2015-07-02
- Data Source
  KAKENHI-PROJECT-25440097
[Presentation] Nuclear protein quality control mechanism involves HSP90 to eliminate aberrant proteins from nucleus2012
- Author(s)
  Takeshi Mizuno, Miwa Higaki, Asami Shibuya, Fumio Hanaoka, Naoko Imamoto
- Organizer
  第64回日本細胞生物学会
- Place of Presentation
  神戸市、兵庫県
- Data Source
  KAKENHI-PROJECT-22570178
[Presentation] 哺乳類細胞核内タンパク質品質管理機構はHSP90と核内のプロテアソームによるタンパク質分解により維持される2012
- Author(s)
  (水野　武)、渋谷麻実、花岡文雄、今本尚子
- Organizer
  第３５回日本分子生物学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22570178
[Presentation] 核局在と点変異がマウスVHLの安定性に与える影響2012
- Author(s)
  渋谷麻実、（水野武）、今本尚子
- Organizer
  第３５回日本分子生物学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22570178
[Presentation] Nuclear protein quality control mechanism involves HSP90 to eliminate aberrant proteins from nucleus2012
- Author(s)
  (Takeshi Mizuno), Miwa Higaki, Asami Shibuya, Fumio Hanaoka, Naoko Imamoto
- Organizer
  第64回日本細胞生物学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22570178
[Presentation] マウステロメア結合タンパク質とＤＮＡポリメラーゼαの相互作用解析2012
- Author(s)
  宮澤沙絵，（水野武），立澤桜子，花岡文雄，今本尚子，鳥越秀峰
- Organizer
  第３５回日本分子生物学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22570178
[Presentation] Intrinsically disordered amino-terminal region of DNA polymerase alpha catalytic subunit is interactive region for other replicative factors.2012
- Author(s)
  (Takeshi Mizuno), Sae Miyazawa, Masako Izumi, Fumio Hanaoka, Naoko Imamoto, Hidetaka Torigoe
- Organizer
  The 8th 3R Symposium
- Place of Presentation
  淡路島、夢舞台
- Data Source
  KAKENHI-PROJECT-22570178
[Presentation] Intrinsically disordered amino-terminal region of DNA polymerase alpha catalytic subunit is interactive region for other replicative factors2012
- Author(s)
  Takeshi Mizuno, Sae Miyazawa, Masako Izumi, Fumio Hanaoka, Naoko Imamoto, Hidetaka Torigoe
- Organizer
  The 8^<th> 3R Symposium
- Place of Presentation
  Awaji, Hyogo
- Data Source
  KAKENHI-PROJECT-22570178
[Presentation] 哺乳類細胞核内タンパク質品質管理機構はHSP90と核内のプロテアソームによるタンパク質分解により維持される。Mammalian nuclear protein quality control is mediated by HSP90 and PA28gamma.2012
- Author(s)
  水野武、渋谷麻実、花岡文雄、今本尚子
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  、福岡県、福岡市
- Data Source
  KAKENHI-PROJECT-22570178
[Presentation] Nuclear protein quality control mechanism involves HSP90 to eliminate aberrant proteins from nucleus2011
- Author(s)
  Takeshi Mizuno, Miwa Higaki, Asami Shibuya, Motoyuki Shimonaka, Fumio Hanaoka, Naoko Imamoto
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  横浜市、神奈川県
- Data Source
  KAKENHI-PROJECT-22570178
[Presentation] Eukaryotic DNA replication and genome Maintenance2011
- Author(s)
  Takeshi Mizuno, Ken-ichiro Yanagi, JunGoo Jee, Masahiro Shirakawa, Fumio Hanaoka, and Naoko Imamoto
- Organizer
  Cold Spring Harbor laboratory Meeting
- Place of Presentation
  Cold Spring Harbor, New York, USA
- Data Source
  KAKENHI-PROJECT-22570178
[Presentation] Nuclear protein quality control mechanism involves HSP90 to eliminate aberrant proteins from nucleus2011
- Author(s)
  T.Mizuno, M.Higaki, A.Shibuya, M.Shimonaka, F.Hanaoka, N.Imamoto
- Organizer
  日本分子生物学会年会
- Place of Presentation
  横浜パシフィコ、横浜
- Year and Date
  2011-12-16
- Data Source
  KAKENHI-PROJECT-22570178
[Presentation] Structure and mutagenesis studies of the C-terminal region of licensing factor Cdt1 enable the identification of key residues for binding to replicative helicase Mcm proteins2010
- Author(s)
  T.Mizuno, et al.
- Organizer
  3R symposium
- Place of Presentation
  富山市
- Year and Date
  2010-10-26
- Data Source
  KAKENHI-PROJECT-22570178
[Presentation] マウスCdt1のMcm結合領域の構造解析2010
- Author(s)
  水野武, 他
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会
- Place of Presentation
  神戸市
- Year and Date
  2010-12-07
- Data Source
  KAKENHI-PROJECT-22570178
[Presentation] 細胞核内にて働く品質管理機構の提唱2010
- Author(s)
  水野武、今本尚子、花岡文雄
- Organizer
  第9回核ダイナミクス研究会
- Place of Presentation
  伊豆市,静岡県
- Data Source
  KAKENHI-PROJECT-22570178
[Presentation] Structure and Mutagenesis Studies of the C-terminal Region of Licensing Factor Cdt1 Enable the Identification of Key Residues for Binding to Replicative Helicase Mcm Proteins2010
- Author(s)
  Takeshi Mizuno, JunGoo Jee, Masahiro Shirakawa and Fumio Hanaoka
- Organizer
  3R new frontier in the 3R
- Place of Presentation
  Toyama, Toyama
- Data Source
  KAKENHI-PROJECT-22570178
[Presentation] 細胞核内にて働く品質管理機構の提唱2010
- Author(s)
  水野武, 他
- Organizer
  第9回核ダイナミクス研究会
- Place of Presentation
  伊豆市
- Year and Date
  2010-05-27
- Data Source
  KAKENHI-PROJECT-22570178
[Presentation] 哺乳類細胞核内の異常タンパク質を排除するタンパク質品質管理機構に働くタンパク質分解系の解析
- Author(s)
  水野　武、渋谷麻実、花岡文雄、今本尚子
- Organizer
  第３６回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド
- Data Source
  KAKENHI-PROJECT-25440097
[Presentation] 哺乳類細胞核内の異常タンパク質を排除するタンパク質品質管理機構に働くタンパク質分解系の解析
- Author(s)
  水野　武、渋谷麻実、花岡文雄、今本尚子
- Organizer
  染色体、核ダイナミクス合同ワークショップ
- Place of Presentation
  箱根
- Data Source
  KAKENHI-PROJECT-25440097

1. FUJITA Masatoshi (30270713)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
2. NISITANI Hidbo (40253455)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

MIZUNO Takeshi 水野 武

水野 武 ミズノ タケシ

Research Projects

Research Products

Co-Researchers

Molecular mechanism of mammalian nuclear protein quality controlPrincipal Investigator

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Molecular mechanism of assembly and control of mammalian replication factoriesPrincipal Investigator

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Molecular mechanisms for pre-replication complexes assembly and its implication in chromosomal stability in mammalian cells

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Studies of molecular mechanism on assembly of mammalian pre-replicative complex and replication apparatusPrincipal Investigator

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高等真核生物の複製関連因子の探索とinsitu核内再構築Principal Investigator

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高等真核生物の新規DNA複製因子の探索とin situ核内再構築Principal Investigator

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哺乳類細胞の複製前クロマチン上に形成されるDNA複製装置複合体の分子構築Principal Investigator

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高等真核生物の複製関連因子の探索とin situ核内再構築Principal Investigator

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哺乳類細胞のDNA複製開始機構の再構成:DNAポリメラーゼαを中心としてPrincipal Investigator

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マウスのDNAポリメラーゼα/プライマーゼ複合体を用いたDNA複製開始機構の解明Principal Investigator

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マウスのDNAポリメラーゼ_α/プライマーゼ複合体を用いたDNA複製開始機構の解明Principal Investigator

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[Book] Quality Control of DNA Polymerase α, Fundamental Aspects of DNA Replication, Jelena Kusic-Tisma (Ed.), ISBN: 978-953-307-259-32011

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Publisher

Data Source

[Book] Effect of a specific mammalian DNA polymerase α inhibitor, dehydroaltenusin, on DNA replication in cultured cells. pp67-111, DNA Replication and Mutation, Raymond P. Leitner (Ed.) ISBN 978-1-61324-490-62011

Author(s)

Publisher

Data Source

[Book] Fundamental Aspects of DNA Replication2011

MIZUNO Takeshi 水野武

水野武ミズノタケシ