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Ogawara Ken-ichi  大河原 賢一

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OOGAWARA Kenichi  大河原 賢一

OGAWARA Ken-ichi  大河原 賢一

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Researcher Number 30291470
Other IDs
Affiliation (Current) 2025: 神戸薬科大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help 2018 – 2023: 神戸薬科大学, 薬学部, 教授
2016 – 2017: 岡山大学, 医歯薬学総合研究科, 准教授
2011 – 2015: 岡山大学, 医歯(薬)学総合研究科, 准教授
2013: 岡山大学, 大学院医歯薬学総合研究科, 准教授
2009 – 2011: 岡山大学, 大学院・医歯薬学総合研究科, 准教授 … More
2008: 岡山大学, 医歯薬学総合研究科, 助教
2007 – 2008: Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Assistant Professor
2006: Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Assistant, 大学院医歯薬学総合研究科, 助手
2005 – 2006: Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Research Assistant, 大学院・医歯薬学総合研究科, 助手
2003 – 2004: 岡山大学, 大学院・自然科学研究科, 助手
1999 – 2001: Okayama University, Graduate School of Natural Science and Technology, Research Associate, 大学院・自然科学研究科, 助手
1997 – 1998: 岡山大学, 薬学部, 助手 Less
Review Section/Research Field
Principal Investigator
Medical pharmacy / Basic Section 47060:Clinical pharmacy-related / Biological pharmacy / Physical pharmacy / Physical pharmacy
Except Principal Investigator
Medical pharmacy / Basic Section 47060:Clinical pharmacy-related / Applied pharmacology / 応用薬理学・医療系薬学 / Biological pharmacy
Keywords
Principal Investigator
抗がん剤 / ドラッグ・デリバリー・システム / リポソーム / がん治療 / エマルション / ドラッグデリバリーシステム / enteric nervous system / 血管新生 / 局所動態 / 抗腫瘍効果 … More / 血管正常化 / ニオソーム / 膜融合 / 薬物放出トリガリング / 血管内皮細胞 / 腫瘍内微小環境 / 薬物送達 / ナノ粒子 / 光線力学療法 / 新生血管 / myenteric plexus / bethanechol / epinephrine / cholinergic neuron / adrenergic neuron / 非アドレナリン作動性-非コリン作動性伝達物質 / 一酸化窒素 / 吸収抑制 / 吸収促進 / 交感神経系 / 単純拡散 / 消化管吸収 / Auerbach神経叢 / Bethanechol / Epinephrine / Enteric nervous system / アウエルバッハ神経叢 / ベタネコール / エピネフリン / コリン作動性神経 / アドレナリン作動性神経 / 腸神経系 / 薬物送達システム / 非イオン性界面活性剤 / パクリタキセル / ドラッグデリバリー / 製剤学 / 細胞内動態 / 体内動態 / 表面特性 / 肝臓 / レセプター介在性エンドサイトーシス / オプソニン / 微粒子性薬物キャリアー … More
Except Principal Investigator
P-glycoprotein / 腸神経系 / Western blot / 消化管吸収 / cephalexin / セロトニン / clonidine / rhodamine123 / PepT1 / enteric nervous system / epinephrine / GITA model / quinidine / adrenaline / 刷子縁膜 / 受動拡散 / 経口吸収 / PEPT1 / Cephalexin / セロトニン代謝異常 / trafficking / BCS class II / Cyp3A / P-gp / 筋層間神経叢 / 粘膜下神経叢 / アドレナリン作動性神経系 / 5-HT / oligopeptide transporter / enteric nerve system / bioavailability / BCRP / MRP2 / Caco-2細胞 / 分泌 / 有機アニオン系化合物 / 経口投与 / griseofulvin / antipyrine / セロトニン異常 / 経細胞経路 / 細胞間隙経路 / 胃排出 / 難水溶性薬物 / 初回通過効果 / Cytochrome P450 3A / 併用療法 / 固形がん / エピジェネティック修飾薬 / 低酸素 / 消化管内移行性 / アルカリフォスファターゼ / タンパク発現 / 尿細管再吸収 / PEPT2 / 滞留性 / gastrointestinal transit / 共培養系 / 腸神経細胞 / 分布容積 / 血漿蛋白結合 / α1-acid glycoprotein / Quinidine / FITC-dextran-4 / TEER / paracellular route / transcellular route / clorgyline / 慢性的セロトニン暴露 / 代謝リプログラミング / がん / リプログラミング / がん代謝 / 遊走浸潤 / トランスポーター / 増殖 / 解糖系 / ヌクレオシド / ナノ材料 / 薬学 / 遺伝子 / ウイルス / 癌 / ナノ粒子製剤 / DDS / 癌微小環境 / リポソーム / 癌関連線維芽細胞 / ナノ粒子 / 腫瘍ターゲティング / Drug delivery system / レオウイルス / 腫瘍溶解性ウイルス / 消化管内分泌 / 経口吸収動態 / 粘膜透過 / 膜抵抗値 / 粘膜透過性 / 回腸 / 空腸 / 吸収増大 / Glycyl-Sarcosine / 水溶性高分子 / brush border membrane / dibutyryl cAMP / 腸管・血管同時灌流 / rhodamine 123 / in vitro dissolution study / prediction / poorly water-soluble drug / oral absorption / 吸収動態予測 / in vitro溶出試験 / 予測 / myenteric plexus / submucosal plexus / colchicine / glycyl-sarcosine / cAMP / dobutamine / D-glucose transport / optimal culture condition / stratified cell layer / HaCaT cells / permeability evaluation / oral mucosa / D-glucose輸送系 / 最適培養条件 / 重層細胞 / HaCaT細胞 / 薬物透過性評価系 / 口腔粘膜 / P-glycoproteir / absorption enhancement / gastrointestinal absorption / 単純拡散 / Voltage-clamp / p-chlorophenylalanine / serotonin(5-HT) / 消化管分泌 / 吸収促進 / transporter / facilitated diffusion / active transport / cultured stratified cell layer / dipeptide / D-glucose / human oral mucosal cells / トランスポータ / 促進拡散 / 能動輸送 / 培養重層細胞 / ジペプチド / D-グルコース / ヒト口腔粘膜上皮細胞 / 平均滞留時間 / 腸移行速度 / 小腸内滞留性 / 非線形性 / 消化管内移行速度 / 経口吸収挙動 / セロトニン枯渇 / Caco-2 / 消化器疾患 / Ussing type chamber / 有機アニオン系薬物 / 発現タンパク / Mrp2 / ラット単離小腸粘膜 / 小腸抽出率 / 吸収クリアランス / 発現タンパク量 / 経口窒収 / SMEDDS製剤 / 補助界面活性剤 / 界面活性剤 / 油脂成分 / 自己乳化型マイクロエマルション / ムチン層 / グリセオフルビン / 放出 / 膵リパーゼ / 胆汁 / 自己乳化型マイクロエマルション製剤 / 自己乳化型マイクロエマルション製剤(SMEDDS) / 難溶解性薬物 / FITC-dextran / bethanechol / クロム親和性細胞 / モノアミンオキシダーゼA / ローダミン123 / P-糖タンパク / 小腸粘膜 / トラフィッキンク / セロトニン症候群 / クロルギリン / P-糖タンパク質 / ベタネコール / アドレナリン / in vivo溶解挙動 / 小腸内移行性 / 代謝学 / 薬物動態 Less
  • Research Projects

    (24 results)
  • Research Products

    (59 results)
  • Co-Researchers

    (8 People)
  •  リポソームからの腫瘍組織選択的薬物放出亢進技術の構築ならびにその治療への応用Principal Investigator

    • Principal Investigator
      大河原 賢一
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47060:Clinical pharmacy-related
    • Research Institution
      Kobe Pharmaceutical University
  •  Novel effective combination chemotherapy using epigenetic modifiers for targeting solid tumors

    • Principal Investigator
      Hosokawa Mika
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47060:Clinical pharmacy-related
    • Research Institution
      Kobe Pharmaceutical University
  •  Effect of ENS dysfunction on drug absorption from small intestine

    • Principal Investigator
      檜垣 和孝
    • Project Period (FY)
      2020 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47060:Clinical pharmacy-related
    • Research Institution
      Okayama University
  •  Metabolic reprogramming and its mechanism by nucleosides in cancer

    • Principal Investigator
      Ueda Kumiko
    • Project Period (FY)
      2019 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47060:Clinical pharmacy-related
    • Research Institution
      Kobe Pharmaceutical University
  •  Development of novel DDS technology for effective treatment of refractory cancerPrincipal Investigator

    • Principal Investigator
      Ogawara Ken-ichi
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47060:Clinical pharmacy-related
    • Research Institution
      Kobe Pharmaceutical University
  •  Analysis of changes in intestinal drug absorption behavior caused by metabolic disorder of serotonin

    • Principal Investigator
      Higaki Kazutaka
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Medical pharmacy
    • Research Institution
      Okayama University
  •  Efficient lysis of cancer-associated fibroblasts by next-generation reovirus and development of innovative cancer virotherapy

    • Principal Investigator
      SAKURAI FUMINORI
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Applied pharmacology
    • Research Institution
      Osaka University
  •  Establishment of novel strategy in cancer treatments based on normalization of tumor vasculaturesPrincipal Investigator

    • Principal Investigator
      Ken-ichi Ogawara
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Medical pharmacy
    • Research Institution
      Okayama University
  •  Analysis of drug absorption behavior under gastrointestintestinal diseases related with abnormal metabolism of serotonin

    • Principal Investigator
      Higaki Kazutaka
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Medical pharmacy
    • Research Institution
      Okayama University
  •  Establishment of novel strategy in cancer treatments based on modulation of microenvironment of tumor tissuesPrincipal Investigator

    • Principal Investigator
      OGAWARA Ken-ichi
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Medical pharmacy
    • Research Institution
      Okayama University
  •  Analysis of drug absorption behavior in the enteric nervous system-related gastrointestinal diseases

    • Principal Investigator
      HIGAKI Kazutaka
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Medical pharmacy
    • Research Institution
      Okayama University
  •  Development of novel delivery system for anti-cancer drugs using niosomes as drug carrierPrincipal Investigator

    • Principal Investigator
      OGAWARA Kenichi
    • Project Period (FY)
      2010 – 2011
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Physical pharmacy
    • Research Institution
      Okayama University
  •  Analysis of dissolution kinetics and first-pass elimination of orally administered drugs and its application to prediction of absorption behavior after oral administration

    • Principal Investigator
      KIMURA Toshikiro
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Medical pharmacy
    • Research Institution
      Okayama University
  •  Systematic analysis of ENS-regulation of drug absorption

    • Principal Investigator
      HIGAKI Kazutaka
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Medical pharmacy
    • Research Institution
      Okayama University
  •  Analysis of first-pass effect in small intestinal mucosa and its application to prediction of drug absorption behavior after oral administration

    • Principal Investigator
      KIMURA Toshikiro
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Medical pharmacy
    • Research Institution
      Okayama University
  •  Addition of various clinical values to poorly water-soluble anti-cancer drugs by formulating them into novel emulsion systemPrincipal Investigator

    • Principal Investigator
      OGAWARA Kenichi
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Medical pharmacy
    • Research Institution
      Okayama University
  •  Regulation of drug absorption by enteric nervous system: Studies on drug secretion via specialized mechanisms.

    • Principal Investigator
      HIGAKI Kazutaka
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Medical pharmacy
    • Research Institution
      Okayama University
  •  Analysis of physiological factors regulating oral absorption behaviors of drugs and its application to prediction of plasma concentration-time profile

    • Principal Investigator
      KIMURA Toshikiro
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Medical pharmacy
    • Research Institution
      Okayama University
  •  Regulation of drug absorption and secretion from gastrointestinal via specialized mechanisms by enteric nervous system

    • Principal Investigator
      HIGAKI Kazutaka
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Medical pharmacy
    • Research Institution
      OKAYAMA UNIVERSITY
  •  Analysis of Drug Permeation Mechanism across Oral Mucosa Using Cultured Stratified Cell Layers

    • Principal Investigator
      KIMURA Toshikiro
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Medical pharmacy
    • Research Institution
      OKAYAMA UNIVERSITY
  •  微粒子性薬物キャリアーを用いた細胞選択的薬物ターゲティングシステムの開発Principal Investigator

    • Principal Investigator
      大河原 賢一
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Physical pharmacy
    • Research Institution
      Okayama University
  •  Regulation of drug absorption from gastrointestinal tract by enteric nerve system

    • Principal Investigator
      HIGAKI Kazutaka
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      OKAYAMA UNIVERSITY
  •  Analysis of Carrier-Mediated Transport Systems in Drug Absorption from Oral Mucosa

    • Principal Investigator
      KIMURA Toshikiro
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Biological pharmacy
    • Research Institution
      OKAYAMA UNIVERSITY
  •  Effect of neurohumoral control on gastrointestinal absorption of drugsPrincipal Investigator

    • Principal Investigator
      OGAWARA Ken-ichi, 檜垣 和孝
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Biological pharmacy
    • Research Institution
      Okayama University

All 2023 2022 2021 2020 2019 2018 2017 2016 2014 2012 2011 2010 2009 2008 2007 2006 2005 2004 Other

All Journal Article Presentation

  • [Journal Article] Possible Regulation of P-Glycoprotein Function by Adrenergic Agonists II: Study with Isolated Rat Jejunal Sheets and Caco-2 Cell monolayers2023

    • Author(s)
      Mukai Hironori、Takanashi Masashi、Ogawara Ken-ichi、Maruyama Masato、Higaki Kazutaka
    • Journal Title

      Journal of Pharmaceutical Sciences

      Volume: accepted Issue: 5 Pages: 1209-1219

    • DOI

      10.1016/j.xphs.2023.11.010

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K07176
  • [Journal Article] 3-deazaneplanocin A, a histone methyltransferase inhibitor, improved the chemoresistance induced under hypoxia in melanoma cells2023

    • Author(s)
      Hosokawa Mika、Tetsumoto Sekai、Yasui Mirano、Kono Yusuke、Ogawara Ken-ichi
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 677 Pages: 26-30

    • DOI

      10.1016/j.bbrc.2023.08.003

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K06699
  • [Journal Article] Effect of excessive serotonin on pharmacokinetics of cephalexin after oral administration: Studies with serotonin-excessive model rats2022

    • Author(s)
      Shun Nakashima, Takeharu Iwamoto, Masashi Takanashi, Ken-ichi Ogawara, Masato Maruyama, Kazutaka Higaki
    • Journal Title

      Pharmaceutical Research

      Volume: 39 Issue: 9 Pages: 2163-2178

    • DOI

      10.1007/s11095-022-03325-8

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K07176
  • [Journal Article] Possible regulation of P-glycoprotein function by adrenergic agonists in a vascular-luminal perfused preparation of small intestine.2022

    • Author(s)
      Hironori Mukai, Masashi Takanashi, Ken-ichi Ogawara, Masato Maruyama, Kazutaka Higaki
    • Journal Title

      Journal of Pharmaceutical Sciences

      Volume: 110 Issue: 12 Pages: 3889-3895

    • DOI

      10.1016/j.xphs.2021.09.014

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K07176
  • [Journal Article] Numerical analysis of apparent decitabine uptake in HCT116 cells: Incorporation of a bidirectional first-order kinetic parameter for ENT1 transport and Michaelis-Menten parameters for subsequent phosphorylation2020

    • Author(s)
      UedaT K, Nakamura T, Tanaka S, Hosokawa M, Iwakawa S, Ogawara K
    • Journal Title

      Drug Metabolism and Pharmacokinetics

      Volume: 35 Issue: 1 Pages: 124-130

    • DOI

      10.1016/j.dmpk.2019.10.002

    • NAID

      50014558578

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K07236
  • [Journal Article] Development of Safe and Potent Oil-in-Water Emulsion of Paclitaxel to Treat Peritoneal Dissemination2017

    • Author(s)
      Ogawara Ken-ichi、Fukuoka Yoshiko、Yoshizawa Yuta、Kimura Toshikiro、Higaki Kazutaka
    • Journal Title

      J. Pharm. Sci.

      Volume: 106 Issue: 4 Pages: 1143-1148

    • DOI

      10.1016/j.xphs.2016.12.029

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K08072
  • [Journal Article] Nanoparticle-Based Photodynamic Therapy: Current Status and Future Application to Improve Outcomes of Cancer Treatment2017

    • Author(s)
      Ogawara Ken-ichi、Higaki Kazutaka
    • Journal Title

      Chemical and Pharmaceutical Bulletin

      Volume: 65 Issue: 7 Pages: 637-641

    • DOI

      10.1248/cpb.c17-00063

    • NAID

      130006772442

    • ISSN
      0009-2363, 1347-5223
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K08072
  • [Journal Article] A novel approach to overcome multidrug resistance: Utilization of P-gp mediated efflux of paclitaxel to attack neighboring vascular endothelial cells in tumors2014

    • Author(s)
      Yoshizawa Y., Ogawara K., Kimura T., Higaki K.
    • Journal Title

      Eur. J. Pharm. Sci.

      Volume: 62 Pages: 274-280

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590194
  • [Journal Article] Determinants for In Vivo Antitumor Effect of Angiogenesis Inhibitor SU5416 Formulated in PEGylated Emulsion2014

    • Author(s)
      Ogawara K., Abe S. Un K., Yoshizawa Y., Kimura T., Higaki K.
    • Journal Title

      J. Pharm. Sci.

      Volume: 103 Pages: 2464-2469

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590194
  • [Journal Article] Sex differences in pharmacokinetics of cilostazol in rats2011

    • Author(s)
      N. Kamada, K. Yamada, M. Odomi, T. Mukai, T. Nishibayashi, K. Ogawara, T. Kimura and K. Higaki
    • Journal Title

      Xenobiotica

      Volume: 41(10) Pages: 903-913

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590158
  • [Journal Article] Effect of adrenergic stimulation on drug absorp- tion via passive diffusion in Caco-2 cells.2009

    • Author(s)
      T.Kimoto, M.Takanashi, H.Mukai, K.Ogawara, T.Kimura, K.Higaki
    • Journal Title

      Int.J.Pharm. 368(1-2)

      Pages: 31-36

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590145
  • [Journal Article] Quantitative evaluation of PEPT1 contribution to oral absorption of cephalexin in rats2009

    • Author(s)
      T. Hironaka, S. Itokawa, K. Ogawara, K. Higaki and T. Kimura
    • Journal Title

      Pharm. Res. 26(1)

      Pages: 40-50

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590144
  • [Journal Article] Evaluation of in-vivo dissolution behavior and GI transit of griseofulvin, a BCS class II drug2008

    • Author(s)
      Y. Fujioka, Y. Metsugi, K. Ogawara, K. Higaki and T. Kimura
    • Journal Title

      Int. J. Pharm. 352(1-2)

      Pages: 36-43

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590144
  • [Journal Article] Regulation of drug absorption from small intestine by enteric nervous system : Studies on passive diffusion2007

    • Author(s)
      T., Kimoto, M., Takanashi, M., Sasaki, K., Ogawara, T., Kimura, K., Higaki
    • Journal Title

      Drug Metab. Rev 39(1)

      Pages: 94-94

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590142
  • [Journal Article] Regulation of P-glycoprotein function by enteric nervous system : Efflux activity and intracellular migration of P-glycoprotein in intestinal epithelial cells2007

    • Author(s)
      H., Mukai, H., Hiraoka, K., Matsushita, K., Ogawara, T., Kimura, K., Higaki
    • Journal Title

      Drug Metab. Rev 39(1)

      Pages: 274-275

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590142
  • [Journal Article] Prediction of oral absorption of griseofulvin, a BCS class II drug, based on GITA model : Utilization of a more suitable medium for in-vitro dissolution study.2007

    • Author(s)
      Y.Fujioka, K.Kadono, Y.Fujie, Y.Metsugi, K.Ogawara, K.Higaki, T.Kimura
    • Journal Title

      J. Control.Rel. (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590124
  • [Journal Article] Upregulation of P-glycoprotein expression in small intestine under chronic serotonin-depleted conditions in rats.2005

    • Author(s)
      H.Hiraoka, H.Kimura, Y.furukawa, K.Ogawara, T.Kimura, K.Higaki
    • Journal Title

      J.Pharmacol.Exp.Ther. 312(1)

      Pages: 248-255

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590110
  • [Journal Article] Pharmacokinetic analysis of in-vivo dissolution and absorption behavior of poorly water-soluble drugs after oral administration.2005

    • Author(s)
      Y.Fujioka, K.Kadono, Y.Fujie, Y.Metsugi, K.Ogawara, K.Higaki, T.Kimura
    • Journal Title

      DrugMetab. Rev. 37 (supp. 2)

      Pages: 399-400

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590124
  • [Journal Article] Regulation of drug transport via P-glycoprotein by enteric nervous system.2005

    • Author(s)
      H.Hiraoka, H.Mukai, Matsushita, K.Ogawara, T.Kimura, K.Higaki
    • Journal Title

      Drug Metab.Rev. 37(suppl 2)

      Pages: 79-80

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590110
  • [Journal Article] Regulation of drug absorption from small intestine by enteric nervous system : Studies on transport via PepT1 and passive diffusion.2005

    • Author(s)
      T.Kimoto, Y.Furukawa, K.Ogawara, T.Kimura, K.Higaki
    • Journal Title

      Drug Metab.Rev. 37(suppl 2)

      Pages: 291-291

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590110
  • [Journal Article] Regulation of drug absorption from small intestine by enteric nervous system I : a poorly absorbable drug via passive diffusion.2004

    • Author(s)
      K.Higaki, M.Sone, K.Ogawara, T.Kimura
    • Journal Title

      Drug Metab.Pharmacokinet. 19(3)

      Pages: 198-205

    • NAID

      80016771596

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590110
  • [Presentation] Span85ニオソームによるPTX内封モノグリセリドニオソームからの放出トリガリング2023

    • Author(s)
      岩﨑 裕加、野田 海渡、河野 裕允、細川 美香、大河原 賢一
    • Organizer
      第73回日本薬学会関西支部総会・大会
    • Data Source
      KAKENHI-PROJECT-23K06227
  • [Presentation] Span80あるいはSpan85ニオソームによるパクリタキセル内封PEGリポソームからの放出トリガリングそその機構解析2023

    • Author(s)
      岩﨑 裕加、大河原 賢一、細川 美香、河野 裕允
    • Organizer
      日本薬剤学会 第38年会
    • Data Source
      KAKENHI-PROJECT-23K06227
  • [Presentation] エピジェネティック修飾薬による細胞内メカニズムの変化は低酸素下における抗がん剤耐性を改善する2022

    • Author(s)
      安井みらの、銕本静会、細川美香、河野裕允、大河原賢一
    • Organizer
      日本薬剤学会 第37回年会
    • Data Source
      KAKENHI-PROJECT-21K06699
  • [Presentation] ヒストンメチル化酵素阻害薬により低酸素下の抗がん剤耐性を改善する機構の検討2022

    • Author(s)
      銕本 静会、細川 美香、安井 みらの、河野 裕允、大河原 賢一
    • Organizer
      第72回 日本薬学会関西支部総会・大会
    • Data Source
      KAKENHI-PROJECT-21K06699
  • [Presentation] エピジェネティック修飾薬前処置による低酸素下がん細胞における抗がん剤効果の改善2021

    • Author(s)
      今西啓泰、細川美香、大江彩恵、田中章太、上田久美子、大河原賢一
    • Organizer
      日本薬剤学会 第36回年会
    • Data Source
      KAKENHI-PROJECT-21K06699
  • [Presentation] エピジェネティック修飾薬は低酸素下がん細胞における抗がん剤の効果を改善する2021

    • Author(s)
      細川美香、今西啓泰、大江彩恵、河野裕允、大河原賢一
    • Organizer
      第71回 日本薬学会関西支部薬学会
    • Data Source
      KAKENHI-PROJECT-21K06699
  • [Presentation] パクリタキセル内封リポソーム製剤の転移性乳がんモデルマウスにおける抗腫瘍効果に及ぼす血管正常化の影響2020

    • Author(s)
      松井 はづき、髙杉 裕太、大河原 賢一、丸山 正人、檜垣 和孝
    • Organizer
      第35回日本薬剤学会
    • Data Source
      KAKENHI-PROJECT-18K06784
  • [Presentation] ドキソルビシン内封リポソーム製剤の悪性黒色腫固形がん治療に及ぼす薬物放出特性の影響2020

    • Author(s)
      家中 悠輔、東條 遥佳、兵頭 健治、石原 比呂之、菊池  寛、大河原 賢一、丸山 正人、檜垣 和孝
    • Organizer
      第35回日本薬剤学会
    • Data Source
      KAKENHI-PROJECT-18K06784
  • [Presentation] ヒト大腸がんHCT116細胞におけるデシタビン取り込みの速度論解析2020

    • Author(s)
      上田久美子、田中章太、細川美香、岩川精吾、大河原賢一
    • Organizer
      日本薬学会第140年会
    • Data Source
      KAKENHI-PROJECT-19K07236
  • [Presentation] 腫瘍溶解性ウイルスであるレオウイルスの前投与は、PEG修飾リポソームの腫瘍集積性を向上させる2019

    • Author(s)
      櫻井文教、平田聖也、大河原賢一、水口裕之
    • Organizer
      第35回日本DDS学会
    • Data Source
      KAKENHI-PROJECT-18K06784
  • [Presentation] 難水溶性-難脂溶性薬物のSelf-nanoemulsifying Drug Delivery System(SNEDDS)製剤化に関する基礎的研究2019

    • Author(s)
      住元 祐介、大川 慎也、大河原 賢一、檜垣 和孝
    • Organizer
      第34回日本薬剤学会
    • Data Source
      KAKENHI-PROJECT-18K06784
  • [Presentation] 光増感剤内封ポリマーナノ粒子製剤を用いた光線力学療法の抗腫瘍効果に及ぼす血管新生阻害剤前投与の影響2019

    • Author(s)
      中野 晶、檜垣 和孝、大河原 賢一
    • Organizer
      日本薬学会第139年会
    • Data Source
      KAKENHI-PROJECT-18K06784
  • [Presentation] ヒト大腸がんHCT116細胞におけるデシタビンの取り込みの速度論解析 サブタイトル ―膜透過クリアランスと代謝クリアランスを含むコンパートメントモデル―2019

    • Author(s)
      上田久美子、田中章太、細川美香、岩川精吾、大河原賢一
    • Organizer
      第69回日本薬学会関西支部総会・大会
    • Data Source
      KAKENHI-PROJECT-19K07236
  • [Presentation] Enhanced tumor accumulation of PEGylated liposomes by pretreatment with oncolytic reovirus in tumor-bearing mice.2019

    • Author(s)
      Fuminori Sakurai, Seiya Hirata, Nozomi Kurisu, Ken-ichi Ogawara, Hiroyuki Mizuguchi
    • Organizer
      第25回日本遺伝子細胞治療学会
    • Data Source
      KAKENHI-PROJECT-18K06784
  • [Presentation] Optimization of cancer treatment with nano-DDS formulations: Knowledge of tumor vasculatures to make things work2018

    • Author(s)
      Ken-ichi Ogawara
    • Organizer
      The 2nd Workshop for Korea-Japan Young Scientists on Pharmaceutics
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K06784
  • [Presentation] 腫瘍溶解性ウイルスであるレオウイルスの前投与によるリポソーム製剤の腫瘍ターゲティング向上に関する検討2018

    • Author(s)
      平田聖也、上撫忠孝、大河原賢一、水口裕之、櫻井文教
    • Organizer
      第68回日本薬学会近畿支部大会
    • Data Source
      KAKENHI-PROJECT-17H04101
  • [Presentation] 腫瘍溶解性ウイルスであるレオウイルスの前投与によるPEG修飾リポソームの腫瘍集積性の向上に関する検討2017

    • Author(s)
      櫻井文教、平田聖也、上撫忠孝、大河原賢一、水口裕之
    • Organizer
      第33回日本DDS学会
    • Data Source
      KAKENHI-PROJECT-17H04101
  • [Presentation] パクリタキセル内封微粒子製剤の抗腫瘍効果に及ぼす血管新生阻害剤との併用効果に関する基礎的研究2016

    • Author(s)
      寺内 克、荒川 奏江、大河原 賢一、檜垣 和孝
    • Organizer
      第31回日本薬剤学会
    • Place of Presentation
      長良川国際会議場、岐阜
    • Year and Date
      2016-05-19
    • Data Source
      KAKENHI-PROJECT-15K08072
  • [Presentation] パクリタキセル内封微粒子製剤の抗腫瘍効果に及ぼす血管新生阻害剤との併用効果に関する基礎的研究2016

    • Author(s)
      寺内 克、荒川 奏江、大河原 賢一、檜垣 和孝
    • Organizer
      第32回日本DDS学会
    • Place of Presentation
      グランシップ、静岡
    • Year and Date
      2016-06-30
    • Data Source
      KAKENHI-PROJECT-15K08072
  • [Presentation] Optimization of cancer treatment with nano-DDS formulations: Knowledge of tumor vasculatures to make things work2016

    • Author(s)
      K. Ogawara
    • Organizer
      International seminar on pharmacology and clinical pharmacy: Current trend of molecular pharmacology in the drug development and clinical use
    • Place of Presentation
      Hotel Harris, Bandong, Indonesia
    • Year and Date
      2016-09-01
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08072
  • [Presentation] セロトニン症候群発症時における薬物の経口吸収挙動に関する基礎的検討2014

    • Author(s)
      坡山幸恵、中島 駿、大河原 賢一、檜垣 和孝
    • Organizer
      日本薬剤学会第29年会
    • Place of Presentation
      ソニックシティ(さいたま市)
    • Data Source
      KAKENHI-PROJECT-23590181
  • [Presentation] セロトニン症候群発症時における薬物の経口吸収挙動に関する基礎的研究2012

    • Author(s)
      中島駿、岩本武晴、高梨雅史、大河原賢一、木村聰城郎、檜垣和孝
    • Organizer
      日本薬剤学会第27年会
    • Place of Presentation
      神戸国際会議場,神戸
    • Data Source
      KAKENHI-PROJECT-23590181
  • [Presentation] ナノDDS製剤を用いたがん治療の最適化:敵を知ることの重要性2012

    • Author(s)
      大河原 賢一、檜垣 和孝
    • Organizer
      創剤フォーラム第18回若手研究会
    • Place of Presentation
      徳島大学薬学部長井記念ホール
    • Invited
    • Data Source
      KAKENHI-PROJECT-24590194
  • [Presentation] 有機アニオン性化合物の経口吸収挙動に及ぼすセロトニン枯渇の影響2011

    • Author(s)
      三木 朋子、橋本 賢太、大河原 賢一、木村 聰城郎、檜垣 和孝
    • Organizer
      日本薬剤学会第26年会
    • Place of Presentation
      タワーホール船堀, 東京
    • Data Source
      KAKENHI-PROJECT-23590181
  • [Presentation] 有機アニオン性化合物の経口吸収挙動に及ぼすセロトニン枯渇の影響2011

    • Author(s)
      三木朋子、橋本賢太、大河原賢一、木村聰城郎、檜垣和孝
    • Organizer
      日本薬剤学会第26年会
    • Place of Presentation
      タワーホール船堀,東京
    • Data Source
      KAKENHI-PROJECT-23590181
  • [Presentation] ドキソルビシン内封ニオソーム製剤の調製とその体内動態特性及び抗腫瘍効果の評価2011

    • Author(s)
      大河原賢一, 西口修平, 宮田竜也, 木村聰城郎, 檜垣和孝
    • Organizer
      第27回日本DDS学会
    • Place of Presentation
      東京大学
    • Year and Date
      2011-06-10
    • Data Source
      KAKENHI-PROJECT-22790036
  • [Presentation] In-Vivo Disposition Characteristics and Anti-Tumor Activity of Doxorubicin-Encapsulating Niosomes2010

    • Author(s)
      西口修平、宮田竜也、大河原賢一、木村聴城郎、檜垣和孝
    • Organizer
      日本薬物動態学会 第25回年回
    • Place of Presentation
      埼玉県大宮市
    • Year and Date
      2010-10-09
    • Data Source
      KAKENHI-PROJECT-22790036
  • [Presentation] In-Vivo Disposition Characteristics and Anti-Tumor Activity of Doxorubicin-Encapsulating Niosomes2010

    • Author(s)
      西口修平, 宮田竜也, 大河原賢一, 木村聰城郎, 檜垣和孝
    • Organizer
      日本薬物動態学会第25回年会
    • Place of Presentation
      大宮市
    • Year and Date
      2010-10-09
    • Data Source
      KAKENHI-PROJECT-22790036
  • [Presentation] Development and evaluation of novel nanoparticle formulation of paclitaxel2008

    • Author(s)
      Yuta Yoshizawa, Yusuke Kono, Yoshiko Fukuoka, Ken-ichi Ogawara, Kazutaka Higaki and Toshikiro Kimura
    • Organizer
      第23回日本薬物動態学会年会
    • Place of Presentation
      熊本
    • Year and Date
      2008-11-01
    • Data Source
      KAKENHI-PROJECT-19790125
  • [Presentation] Regulation of Drug Absorption from Small Intestine by Enteric Nervous System : Studies on Passive Diffusion2007

    • Author(s)
      Takahiro, Kimoto, Masashi, Takanashi, Moeko, Sasaki, Ken-ichi Ogawara, Toshikiro, Kimura, Kazutaka, Higaki
    • Organizer
      8th International ISSX Meeting
    • Place of Presentation
      Sendai International Center, Sendai, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590142
  • [Presentation] Regulation of P-glycoprotein Function by Enteric Nervous System : Efflux Activity and Intracellular Migration of P-glycoprotein in Intestinal Epithelial Cells2007

    • Author(s)
      Hironori, Mukai, Hideo, Hiraoka, Kotaro, Matsushita, Kenichi, Ogawara, Toshikiro, Kimura, Kazutaka, Higaki
    • Organizer
      8th International ISSX Meeting
    • Place of Presentation
      Sendai International Center, Sendai, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590142
  • [Presentation] Regulation of drug absorption from small intestine by enteric nervous system : Studies on passive diffusion and P-gp function2007

    • Author(s)
      Takahiro, Kimoto, Hideo, Hiraoka, Hironori, Mukai, Moeko, Sasaki, Kenichi, Ogawara, Toshikiro, Kimura, Kazutaka, Higaki
    • Organizer
      4th Pharmaceutical Sciences World Congress
    • Place of Presentation
      RAI Congress Center, Amsterdam, Netherlands
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590142
  • [Presentation] Regulation of drug transport via P-glycoprotein by enteric nervous system in Caco-2 monolayers2006

    • Author(s)
      Hironori, Mukai, Hideo, Hiraoka, Kotaro, Matsushita, Kenichi, Ogawara, Toshikiro,Kimura, Kazutaka, Higaki
    • Organizer
      21st Japanese Society for the Study of Xenobiotics Annual Meeting
    • Place of Presentation
      Tower Hall Funabori, Tokyo, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590142
  • [Presentation] Regulation of drug absorption via passive diffusion from small intestine by enteric nervous system2006

    • Author(s)
      Takahiro, Kimoto, Moeko, Sasaki, Ken-ichi, Ogawara, Toshikiro, Kimura, Kazutaka, Higaki
    • Organizer
      21st Japanese Society for the Study of Xenobiotics Annual Meeting
    • Place of Presentation
      Tower Hall Funabori, Tokyo, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590142
  • [Presentation] セロトニン症候群発症時における薬物の経口吸収挙動に関する基礎的検討

    • Author(s)
      坡山幸恵、中島駿、大河原賢一、檜垣和孝
    • Organizer
      日本薬剤学会第29年会
    • Place of Presentation
      ソニックシティ(さいたま市)
    • Year and Date
      2014-05-20 – 2014-05-22
    • Data Source
      KAKENHI-PROJECT-26460197
  • [Presentation] パクリタキセル内封微粒子製剤の抗腫瘍効果に及ぼす血管新生阻害剤との併用効果に関する基礎的研究

    • Author(s)
      荒川 奏江、石川 啓輔、大河原 賢一、檜垣 和孝
    • Organizer
      第29回日本薬剤学会
    • Place of Presentation
      大宮ソニックビル
    • Year and Date
      2014-05-20 – 2014-05-22
    • Data Source
      KAKENHI-PROJECT-24590194
  • [Presentation] Augmented EPR effect by photo-triggered tumor vascular treatment improved therapeutic efficacy of liposomal paclitaxel in mice bearing tumors with low permeable vasculature

    • Author(s)
      Ken-ichi Ogawara, Tomoya Araki, Rie Kawai, Haruka Suzuki, Kazutaka Higaki
    • Organizer
      第8回次世代を担う若手医療薬科学シンポジウム
    • Place of Presentation
      熊本大学薬学部
    • Year and Date
      2014-11-15 – 2014-11-16
    • Data Source
      KAKENHI-PROJECT-24590194
  • [Presentation] 光線力学的前処置が及ぼす腫瘍内血管透過性及びパクリタキセル内封PEGリポソーム製剤の抗腫瘍効果への影響

    • Author(s)
      荒木 知哉、大河原 賢一、檜垣 和孝
    • Organizer
      第135回日本薬学会
    • Place of Presentation
      神戸学院大学など
    • Year and Date
      2015-03-26 – 2015-03-28
    • Data Source
      KAKENHI-PROJECT-24590194
  • 1.  HIGAKI Kazutaka (60284080)
    # of Collaborated Projects: 17 results
    # of Collaborated Products: 38 results
  • 2.  KIMURA Toshikiro (10025710)
    # of Collaborated Projects: 11 results
    # of Collaborated Products: 20 results
  • 3.  KAWAI Keiichi (30204663)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 4.  SAKURAI FUMINORI (70370939)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 5.  Ueda Kumiko (10309437)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 6.  Hosokawa Mika (70548271)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results
  • 7.  丸山 正人 (00399445)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 8.  河野 裕允 (60732823)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results

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