NOZU Tsukasa 野津司

… Alternative Names

野津司ノヅツカサ

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Researcher Number	30312367
Other IDs
Affiliation (Current)	2025: 旭川医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2019 – 2024: 旭川医科大学, 医学部, 教授 2010 – 2018: 旭川医科大学, 医学部, 准教授 2000 – 2001: 北海道大学, 医学部・附属病院, 助手
Review Section/Research Field	Principal Investigator General physiology / Basic Section 55020:Digestive surgery-related / Basic Section 53010:Gastroenterology-related / Gastroenterology Except Principal Investigator Basic Section 53010:Gastroenterology-related / Gastroenterology / Basic Section 52010:General internal medicine-related / Neurophysiology / General neuroscience
Keywords	Principal Investigator サイトカイン / ストレス / 内臓知覚 / 過敏性腸症候群 / TLR4 / 内臓感覚 / CRF / LPS / 消化管運動 / 脳血管バリアー … More / 術後せん妄 / NLRP3インフラマソーム / グレリン / SGLT2阻害薬 / 術後イレウス / 腸管透過性 / 消化管バリア / 内臓知覚過敏 / うつ病 / メタボリック症候群 / メタボリックシンドローム / 腸管バリアー / 腸管感覚 / 胃運動 / 大腸運動 / CRF受容体 / IL-1 / dopamine / 消化管機能 / 迷走神経 / オレキシン / 末梢CRF受容体 / 大腸収縮 / 胃収縮 / corticotropin releasing factor (CRF) / Functional abdominal pain syndrome / ドクターショッピング / corticotropin releasing factor / barostat … More Except Principal Investigator 腸管バリア機能 / グレリン / 過敏性腸症候群 / ラット / 中枢神経 / オレキシン / 迷走神経 / アデノシン / ドパミン / 内臓知覚 / 抗炎症作用 / 敗血症 / 敗血症死 / コリン性作動性ニューロン / histamine / 腸管バリア / 中枢神経系 / IBS / Butyrate / Orexin / Ghrelin / Adenosine A2B / Brain / Leaky gut / セロトニン / オピオイド / 脳 / オキシトシン / GABA作動性経路 / ウイルスベクター / 視蓋脊髄路 / 脳深部刺激 / コリン作動性ニューロン / 中脳歩行誘発野 / 歩行誘発野 / 筋緊張 / 予期的姿勢調節 / 姿勢反射 / 姿勢筋緊張 / 脚橋被蓋核 / GABA作動性投射 / 黒質網様部 / パーキンソン病 / 前庭脊髄路 / 網様体脊髄路 / 歩行 / 姿勢制御 / 直腸伸展刺激 / カンナビノイド / 睡眠 / 脳波 / 睡眠覚醒サイクル / 消化管運動 / がん細胞増殖 / 血管新生 / VEGF / cancer / PPARgamma Less

脳内histamine神経系による腸管バリア制御機序の解明とleaky gut関連疾患への治療応用
- Principal Investigator
  
  石王応知
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Asahikawa Medical College
中枢神経系を介した敗血症死阻止メカニズムの解明　-Ghrelinの関与ー
- Principal Investigator
  
  奥村利勝
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Asahikawa Medical College
腹部手術後イレウスと術後せん妄に対する新規治療法の探究Principal Investigator
- Principal Investigator
  
  野津司
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Asahikawa Medical College
Elucidation of the Mechanism of the Central Nervous System Regulation of Intestinal Barrier Function and Its Application to the Treatment of Leaky Gut-related Disease
- Principal Investigator
  
  Ishioh Masatomo
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Asahikawa Medical College
Central mechanism of visceral sensation with special reference to brain orexin and its clinical application for irritable bowel syndrome
- Principal Investigator
  
  Okumura Toshikatsu
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Asahikawa Medical College
Exploring novel therapies on the basis of pathophysiological commonality between irritable bowel syndrome and metabolic syndromePrincipal Investigator
- Principal Investigator
  
  Nozu Tsukasa
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Asahikawa Medical College
Roles of LPS, cytokine and peripheral CRF receptors on gastrointestinal functionPrincipal Investigator
- Principal Investigator
  
  Nozu Tsukasa
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Asahikawa Medical College
Role of brain orexin in the pathogenesis of irritable bowel syndrome
- Principal Investigator
  
  Toshikatsu Okumura
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Asahikawa Medical College
Mechanisms of postural control operated by the basal ganglia, brainstem and spinal cord
- Principal Investigator
  
  Takakusaki Kaoru
- Project Period (FY)
  2013 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurophysiology / General neuroscience
- Research Institution
  Asahikawa Medical College
The role and the mechanisms of orexin in modulating gastrointestinal functionPrincipal Investigator
- Principal Investigator
  
  NOZU Tsukasa
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Asahikawa Medical College
Relationship between sleep-awake cycle and gastrointestinal motility
- Principal Investigator
  
  OHHIRA Masumi
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Gastroenterology
- Research Institution
  Asahikawa Medical College
Anti-tumor action by PPARgamma ligands in pancreatic cancer: analysis of angigenesis-related genes expression
- Principal Investigator
  
  OKUMURA Toshikatsu
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Asahikawa Medical College
消化管機能異常症の病態生理に関する神経内分泌学的検討Principal Investigator
- Principal Investigator
  
  野津司
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Gastroenterology
- Research Institution
  Hokkaido University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 Other

All Journal Article Presentation

[Journal Article] Brain Neuropeptides, Neuroinflammation, and Irritable Bowel Syndrome2024
- Author(s)
  Ishioh, M. Nozu, T. Okumura, T.
- Journal Title
  
  Digestion
  
  Volume: 105 Issue: 1 Pages: 34-39
- DOI
  10.1159/000533275
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08790, KAKENHI-PROJECT-21K07883
[Journal Article] Phlorizin attenuates postoperative gastric ileus in rats2023
- Author(s)
  Nozu, T. Miyagishi, S. Ishioh, M. Takakusaki, K. Okumura, T.
- Journal Title
  
  Neurogastroenterol Motil
  
  Volume: 35 Issue: 11
- DOI
  10.1111/nmo.14659
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K08790
[Journal Article] Ghrelin prevents lethality in a rat endotoxemic model through central effects on the vagal pathway and adenosine A2B signaling : Brain ghrelin and anti-septic action.2023
- Author(s)
  Igarashi S, Nozu T, Ishioh M, Funayama T, Sumi C, Saito T, Toki Y, Hatayama M, Yamamoto M, Shindo M, Tanabe H, Okumura T.
- Journal Title
  
  J Physiol Biochem.
  
  Volume: - Issue: 3 Pages: 625-634
- DOI
  10.1007/s13105-023-00962-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08746, KAKENHI-PROJECT-23K06842
[Journal Article] Imeglimin prevents visceral hypersensitivity and colonic hyperpermeability in irritable bowel syndrome rat model2023
- Author(s)
  Nozu, Tsukasa Miyagishi, Saori Ishioh, Masatomo Takakusaki, Kaoru Okumura, Toshikatsu
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 153 Issue: 1 Pages: 26-30
- DOI
  10.1016/j.jphs.2023.07.002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08790
[Journal Article] Peripheral apelin mediates visceral hypersensitivity and impaired gut barrier in a rat irritable bowel syndrome model2022
- Author(s)
  Nozu, T. Miyagishi, S. Ishioh, M. Takakusaki, K. Okumura, T.
- Journal Title
  
  Neuropeptides
  
  Volume: 94 Pages: 102248-102248
- DOI
  10.1016/j.npep.2022.102248
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07896, KAKENHI-PROJECT-22K08790, KAKENHI-PLANNED-19H05726
[Journal Article] Activation of basal forebrain cholinergic neurons improves colonic hyperpermeability through the vagus nerve and adenosine A2B receptors in rats2022
- Author(s)
  Ishioh, M., Nozu, T., Miyagishi, S., Igarashi, S., Funayama, T., Ohhira, M., Okumura, T.,
- Journal Title
  
  Biochem Pharmacol
  
  Volume: 206 Pages: 115331-115331
- DOI
  10.1016/j.bcp.2022.115331
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K07883
[Journal Article] Pathophysiological Commonality Between Irritable Bowel Syndrome and Metabolic Syndrome: Role of Corticotropin-releasing Factor-Toll-like Receptor 4-Proinflammatory Cytokine Signaling2022
- Author(s)
  Nozu, T. Okumura, T.
- Journal Title
  
  J Neurogastroenterol Motil
  
  Volume: 28 Issue: 2 Pages: 173-184
- DOI
  10.5056/jnm21002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07896, KAKENHI-PROJECT-22K08790
[Journal Article] EMA401, an angiotensin II type 2 receptor antagonist blocks visceral hypersensitivity and colonic hyperpermeability in rat model of irritable bowel syndrome2021
- Author(s)
  Nozu, T. Miyagishi, S. Nozu, R. Ishioh, M. Takakusaki, K. Okumura, T.
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 146 Issue: 3 Pages: 121-124
- DOI
  10.1016/j.jphs.2021.04.001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07896, KAKENHI-PLANNED-19H05726
[Journal Article] Activation of central adenosine A2B receptors mediate brain ghrelin-induced improvement of intestinal barrier function through the vagus nerve in rats2021
- Author(s)
  Ishioh Masatomo、Nozu Tsukasa、Igarashi Sho、Tanabe Hiroki、Kumei Shima、Ohhira Masumi、Takakusaki Kaoru、Okumura Toshikatsu
- Journal Title
  
  Experimental Neurology
  
  Volume: 341 Pages: 113708-113708
- DOI
  10.1016/j.expneurol.2021.113708
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08410, KAKENHI-PLANNED-19H05726, KAKENHI-PROJECT-21K07883
[Journal Article] Central regulatory mechanisms of visceral sensation in response to colonic distension with special reference to brain orexin2021
- Author(s)
  Okumura Toshikatsu、Ishioh Masatomo、Nozu Tsukasa
- Journal Title
  
  Neuropeptides
  
  Volume: 86 Pages: 102129-102129
- DOI
  10.1016/j.npep.2021.102129
- Data Source
  KAKENHI-PROJECT-19K08410
[Journal Article] Phlorizin attenuates visceral hypersensitivity and colonic hyperpermeability in a rat model of irritable bowel syndrome2021
- Author(s)
  Nozu, T. Miyagishi, S. Ishioh, M. Takakusaki, K. Okumura, T.
- Journal Title
  
  Biomed Pharmacother
  
  Volume: 139 Pages: 111649-111649
- DOI
  10.1016/j.biopha.2021.111649
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07896, KAKENHI-PLANNED-19H05726
[Journal Article] 5-HT2A receptors but not cannabinoid receptors in the central nervous system mediate levodopa-induced visceral antinociception in conscious rats.2020
- Author(s)
  Okumura T, Nozu T, Ishioh M, Igarashi S, Kumei S, Ohhira M.
- Journal Title
  
  Naunyn Schmiedebergs Arch Pharmacol.
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08410
[Journal Article] Losartan improves visceral sensation and gut barrier in a rat model of irritable bowel syndrome2020
- Author(s)
  Nozu Tsukasa、Miyagishi Saori、Nozu Rintaro、Takakusaki Kaoru、Okumura Toshikatsu
- Journal Title
  
  Neurogastroenterology & Motility
  
  Volume: in press Issue: 6 Pages: 0-0
- DOI
  10.1111/nmo.13819
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07896, KAKENHI-PLANNED-19H05726, KAKENHI-PROJECT-19K08410
[Journal Article] Adenosine A1 receptor agonist induces visceral antinociception via 5-HT1A, 5-HT2A, dopamine D1 or cannabinoid CB1 receptors, and the opioid system in the central nervous system2020
- Author(s)
  Okumura Toshikatsu、Nozu Tsukasa、Ishioh Masatomo、Igarashi Sho、Kumei Shima、Ohhira Masumi
- Journal Title
  
  Physiology & Behavior
  
  Volume: 220 Pages: 112881-112881
- DOI
  10.1016/j.physbeh.2020.112881
- Open Access
- Data Source
  KAKENHI-PROJECT-19K08410
[Journal Article] Ghrelin acts in the brain to block colonic hyperpermeability in response to lipopolysaccharide through the vagus nerve2020
- Author(s)
  Ishioh Masatomo、Nozu Tsukasa、Igarashi Sho、Tanabe Hiroki、Kumei Shima、Ohhira Masumi、Okumura Toshikatsu
- Journal Title
  
  Neuropharmacology
  
  Volume: 173 Pages: 108116-108116
- DOI
  10.1016/j.neuropharm.2020.108116
- Open Access
- Data Source
  KAKENHI-PROJECT-19K08410
[Journal Article] 5-HT2A receptors but not cannabinoid receptors in the central nervous system mediate levodopa-induced visceral antinociception in conscious rats2020
- Author(s)
  Okumura Toshikatsu、Nozu Tsukasa、Ishioh Masatomo、Igarashi Sho、Kumei Shima、Ohhira Masumi
- Journal Title
  
  Naunyn-Schmiedeberg's Archives of Pharmacology
  
  Volume: 393 Issue: 8 Pages: 1419-1425
- DOI
  10.1007/s00210-020-01842-0
- Open Access
- Data Source
  KAKENHI-PROJECT-19K08410
[Journal Article] Centrally administered orexin prevents lipopolysaccharide and colchicine induced lethality via the vagal cholinergic pathway in a sepsis model in rats2020
- Author(s)
  Igarashi Sho、Nozu Tsukasa、Ishioh Masatomo、Kumei Shima、Saito Takeshi、Toki Yasumichi、Hatayama Mayumi、Yamamoto Masayo、Shindo Motohiro、Tanabe Hiroki、Okumura Toshikatsu
- Journal Title
  
  Biochemical Pharmacology
  
  Volume: 182 Pages: 114262-114262
- DOI
  10.1016/j.bcp.2020.114262
- Open Access
- Data Source
  KAKENHI-PROJECT-19K08410
[Journal Article] Imipramine improves visceral sensation and gut barrier in rat models of irritable bowel syndrome2020
- Author(s)
  Nozu, T. Miyagishi, S. Ishioh, M. Takakusaki, K. Okumura, T.
- Journal Title
  
  Eur J Pharmacol
  
  Volume: 887 Pages: 173565-173565
- DOI
  10.1016/j.ejphar.2020.173565
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07896, KAKENHI-PROJECT-19K08410, KAKENHI-PLANNED-19H05726
[Journal Article] Brain orexin improves intestinal barrier function via the vagal cholinergic pathway2020
- Author(s)
  Okumura Toshikatsu、Nozu Tsukasa、Ishioh Masatomo、Igarashi Sho、Kumei Shima、Ohhira Masumi
- Journal Title
  
  Neuroscience Letters
  
  Volume: 714 Pages: 134592-134592
- DOI
  10.1016/j.neulet.2019.134592
- Open Access
- Data Source
  KAKENHI-PROJECT-19K08410, KAKENHI-PROJECT-18K15739
[Journal Article] Dehydroepiandrosterone sulfate improves visceral sensation and gut barrier in a rat model of irritable bowel syndrome.2019
- Author(s)
  Nozu T, Miyagishi S, Nozu R, Takakusaki K, Okumura T.
- Journal Title
  
  Eur J Pharmacol.
  
  Volume: 852 Pages: 198-206
- DOI
  10.1016/j.ejphar.2019.03.037
- NAID
  120006878173
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-26120004, KAKENHI-PROJECT-18K07896, KAKENHI-PLANNED-19H05726
[Journal Article] Butyrate inhibits visceral allodynia and colonic hyperpermeability in rat models of irritable bowel syndrome2019
- Author(s)
  Nozu Tsukasa、Miyagishi Saori、Nozu Rintaro、Takakusaki Kaoru、Okumura Toshikatsu
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 19603-19603
- DOI
  10.1038/s41598-019-56132-4
- NAID
  120006775256
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07896, KAKENHI-PLANNED-19H05726
[Journal Article] Metformin inhibits visceral allodynia and increased gut permeability induced by stress in rats2019
- Author(s)
  Nozu, T. Miyagishi, S. Kumei, S. Nozu, R. Takakusaki, K. Okumura, T.
- Journal Title
  
  J Gastroenterol Hepatol
  
  Volume: 34 Issue: 1 Pages: 186-193
- DOI
  10.1111/jgh.14367
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07896, KAKENHI-PLANNED-26120004
[Journal Article] Ghrelin acts centrally to induce an antinociceptive action during colonic distension through the orexinergic, dopaminergic and opioid systems in conscious rats.2018
- Author(s)
  Okumura T, Nozu T, Kumei S, Takakusaki K, Ohhira M.
- Journal Title
  
  Brain Res.
  
  Volume: 1686 Pages: 48-54
- Data Source
  KAKENHI-PROJECT-26460955
[Journal Article] Altered colonic sensory and barrier functions by CRF: roles of TLR4 and IL-12018
- Author(s)
  Nozu, T. Miyagishi, S. Nozu, R. Takakusaki, K. Okumura, T.
- Journal Title
  
  J Endocrinol
  
  Volume: 239 Issue: 2 Pages: 241-151
- DOI
  10.1530/joe-18-0441
- NAID
  120006769835
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07896, KAKENHI-PLANNED-26120004
[Journal Article] A Hypothesis for Understanding Mechanisms of Normal and Abnormal Behavior States Based on Operation Hypothesis.2018
- Author(s)
  Takakusaki K, Takahashi M, Nakajima T, Chiba R, Obara K, Nozu T, Okumura T
- Journal Title
  
  Sleep Med Dis Int J
  
  Volume: 2(1) Issue: 1 Pages: 00031-00031
- DOI
  10.15406/smdij.2018.02.00031
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25290001, KAKENHI-PLANNED-26120004
[Journal Article] Pioglitazone improves visceral sensation and colonic permeability in a rat model of irritable bowel syndrome2018
- Author(s)
  Nozu, T. Miyagishi, S. Nozu, R. Takakusaki, K. Okumura, T.
- Journal Title
  
  J Pharmacol Sci
  
  Volume: 139 Issue: 1 Pages: 46-49
- DOI
  10.1016/j.jphs.2018.11.006
- NAID
  120006643359
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07896, KAKENHI-PLANNED-26120004, KAKENHI-PLANNED-19H05726
[Journal Article] Ghrelin acts centrally to induce an antinociceptive action during colonic distension through the orexinergic, dopaminergic and opioid systems in conscious rats.2018
- Author(s)
  Okumura T, Nozu T, Kumei S, Takakusaki K, Ohhira M.
- Journal Title
  
  Brain Res.
  
  Volume: 1686 Pages: 48-54
- DOI
  10.1016/j.brainres.2018.02.024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25290001, KAKENHI-PLANNED-26120004
[Journal Article] Lovastatin inhibits visceral allodynia and increased colonic permeability induced by lipopolysaccharide or repeated water avoidance stress in rats.2018
- Author(s)
  Nozu T, Miyagishi S, Kumei S, Nozu R, Takakusaki K, Okumura T
- Journal Title
  
  Eur J Pharmacol.
  
  Volume: 818 Pages: 228-234
- DOI
  10.1016/j.ejphar.2017.10.056
- NAID
  120006552898
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25290001, KAKENHI-PROJECT-26460287
[Journal Article] Lipopolysaccharide induces visceral hypersensitivity: role of interleukin-1, interleukin-6, and peripheral corticotropin-releasing factor in rats.2017
- Author(s)
  Nozu T, Miyaghisi S, Nozu R, Takakusaki K, Okumura T.
- Journal Title
  
  J Gastroenterol.
  
  Volume: 80(5) Issue: 1 Pages: 70-82
- DOI
  10.1007/s00535-016-1208-y
- NAID
  120006220854
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-26120004, KAKENHI-PROJECT-25290001, KAKENHI-PROJECT-26460287
[Journal Article] Repeated water avoidance stress induces visceral hypersensitivity; role of IL-1, IL-6 and peripheral corticotropin-releasing factor2017
- Author(s)
  Nozu T, Miyagishi S, Nozu R, Takakusaki K, Okumura T.
- Journal Title
  
  J Gastroenterol Hepatol.
  
  Volume: in press Issue: 12 Pages: 1958-1965
- DOI
  10.1111/jgh.13787
- NAID
  120006425800
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-26120004, KAKENHI-PROJECT-25290001, KAKENHI-PROJECT-26460287
[Journal Article] A glucagon-like peptide-1 analog, liraglutide improves visceral sensation and gut permeability in rats2017
- Author(s)
  Nozu T, Miyagishi S, Kumei S, Nozu R, Takakusaki K, Okumura T.
- Journal Title
  
  J Gastroenterol Hepatol.
  
  Volume: in press Issue: 1 Pages: 232-239
- DOI
  10.1111/jgh.13808
- NAID
  120006462336
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-26120004, KAKENHI-PROJECT-25290001, KAKENHI-PROJECT-26460287
[Journal Article] Lipopolysaccharide induces visceral hypersensitivity: role of interleukin-1, interleukin-6, and peripheral corticotropin-releasing factor in rats.2016
- Author(s)
  Nozu T, Miyagishi S, Nozu R, Takakusaki K, Okumura T.
- Journal Title
  
  J Gastroenterol (in press)
  
  Volume: in press
- NAID
  120006220854
- Data Source
  KAKENHI-PROJECT-25290001
[Journal Article] Levodopa acts centrally to induce an antinociceptive action against colonic distension through activation of D2 dopamine receptors and the orexinergic system in the brain in conscious rats.2016
- Author(s)
  2.Okumura T, Nozu T, Kumei S, Takakusaki K, Miyagishi S, Ohhira M
- Journal Title
  
  J Pharmacol Sci.
  
  Volume: 130(2): Pages: 123-127
- NAID
  120005763350
- Data Source
  KAKENHI-PROJECT-26460955
[Journal Article] Water avoidance stress induces visceral hyposensitivity through peripheral corticotropin releasing factor receptor type 2 and central dopamine D2 receptor in rats2016
- Author(s)
  Nozu, T. Miyagishi, S. Nozu, R. Takakusaki, K. Okumura, T.
- Journal Title
  
  Neurogastroenterol Motil
  
  Volume: 28 Issue: 4 Pages: 522-531
- DOI
  10.1111/nmo.12747
- NAID
  120005941041
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460287, KAKENHI-PLANNED-26120004, KAKENHI-PROJECT-25290001
[Journal Article] Levodopa acts centrally to induce an antinociceptive action against colonic distension through activation of D2 dopamine receptors and the orexinergic system in the brain in conscious rats.2016
- Author(s)
  Okumura T, Nozu T, Kumei S, Takakusaki K, Miyagishi S, Ohhira M.
- Journal Title
  
  J Pharmacol Sci.
  
  Volume: 130 Issue: 2 Pages: 123-127
- DOI
  10.1016/j.jphs.2016.01.007
- NAID
  120005763350
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25290001, KAKENHI-PLANNED-26120004
[Journal Article] Adenosine A1 receptors mediate the intracisternal injection of orexin-induced antinociceptive action against colonic distension in conscious rats.2016
- Author(s)
  1.Okumura T, Nozu T, Kumei S, Takakusaki K, Miyagishi S, Ohhira M.
- Journal Title
  
  J Neurol Sci.
  
  Volume: 362 Pages: 106-110
- Data Source
  KAKENHI-PROJECT-26460955
[Journal Article] Brainstem control of locomotion and muscle tone with special reference to the role of the mesopontine tegmentum and medullary reticulospinal systems.2016
- Author(s)
  Takakusaki K, Chiba R, Nozu T, Okumura T.
- Journal Title
  
  J Neural Transm
  
  Volume: in press Issue: 7 Pages: 695-729
- DOI
  10.1007/s00702-015-1475-4
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-26120004, KAKENHI-PLANNED-26120006, KAKENHI-PROJECT-25290001
[Journal Article] Adenosine A1 receptors mediate the intracisternal injection of orexin-induced antinociceptive action against colonic distension in conscious rats.2016
- Author(s)
  Okumura T, Nozu T, Kumei S, Takakusaki K, Miyagishi S, Ohhira M.
- Journal Title
  
  J Neurol Sci.
  
  Volume: 362 Pages: 106-110
- DOI
  10.1016/j.jns.2016.01.031
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-26120004, KAKENHI-PROJECT-25290001
[Journal Article] Colorectal distention induces acute and delayed visceral hypersensitivity: role of peripheral corticotropin-releasing factor and interleukin-1 in rats2015
- Author(s)
  Nozu, T. Kumei, S. Miyagishi, S. Takakusaki, K. Okumura, T.
- Journal Title
  
  J Gastroenterol
  
  Volume: 50 Issue: 12 Pages: 1153-1161
- DOI
  10.1007/s00535-015-1070-3
- NAID
  120005740467
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460287, KAKENHI-PLANNED-26120004, KAKENHI-PROJECT-25290001
[Journal Article] Antinociceptive action against colonic distension by brain orexin in conscious rats2015
- Author(s)
  Okumura T, Nozu T, Kumei S, Takakusaki K, Miyagishi S, Ohhira M
- Journal Title
  
  Brain Research
  
  Volume: 1598 Pages: 12-17
- DOI
  10.1016/j.brainres.2014.12.021
- NAID
  120005712587
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25290001, KAKENHI-PLANNED-26120004, KAKENHI-PROJECT-26460955
[Journal Article] Involvement of the dopaminergic system in the central orexin-induced anitinociceptive action aganist colonic distension in conscious rat.2015
- Author(s)
  Okumura T　Nozu T　Kumiei S, Takakusaki K, Miyagishi S,Ohhira M,
- Journal Title
  
  Neurosci Lett.
  
  Volume: 605 Pages: 34-38
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460955
[Journal Article] Corticotropin-releasing factor receptor type 1 and type 2 interaction in irritable bowel syndrome2015
- Author(s)
  Nozu, T. Okumura, T.
- Journal Title
  
  J Gastroenterol
  
  Volume: 50 Issue: 8 Pages: 819-830
- DOI
  10.1007/s00535-015-1086-8
- NAID
  120005941030
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460287
[Journal Article] Involvement of the dopaminergic system in the central orexin-induced antinociceptive action against colonic distension in conscious rats.2015
- Author(s)
  Okumura T, Nozu T, Kumei S, Takakusaki K, Miyagishi S, Ohhira M.
- Journal Title
  
  Neurosci Lett.
  
  Volume: 605 Pages: 34-38
- DOI
  10.1016/j.neulet.2015.08.013
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-26120004, KAKENHI-PROJECT-25290001
[Journal Article] Colorectal distention induces acute and delayed visceral hypersensitivity: role of peripheral corticotropin-releasing factor and interleukin-1 in rats2015
- Author(s)
  Nozu T, Kumei S, Miyagishi S, Takakusaki K, Okumura T
- Journal Title
  
  J Gastroenterol
  
  Volume: 印刷中
- NAID
  120005740467
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25290001
[Journal Article] A balance theory of peripheral corticotropin-releasing factor receptor type 1 and type 2 signaling to induce colonic contractions and visceral hyperalgesia in rats2014
- Author(s)
  Nozu T, Takakusaki K, Okumura T
- Journal Title
  
  Endocrinology
  
  Volume: 155 Issue: 12 Pages: 4655-4664
- DOI
  10.1210/en.2014-1421
- NAID
  120005690949
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25290001, KAKENHI-PLANNED-26120004, KAKENHI-PROJECT-26460287
[Journal Article] Urocortin 2 blocks the suppression of gastric antral contractions induced by lipopolysaccharide in freely moving conscious rats2014
- Author(s)
  Nozu T, Takakusaki K, Okumura T
- Journal Title
  
  Regulatory Peptides
  
  Volume: (in press) Pages: 12-17
- DOI
  10.1016/j.regpep.2014.04.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590252, KAKENHI-PROJECT-23650202, KAKENHI-PROJECT-25290001, KAKENHI-PLANNED-26120004, KAKENHI-PROJECT-26460287
[Journal Article] Peripheral corticotropin-releasing factor (CRF) induces stimulation of gastric contractions in freely moving conscious rats: role of CRF receptor types 1 and 2.2013
- Author(s)
  Nozu T, Tsuchiya Y, Kumei S, Takakusaki K, Okumura T.
- Journal Title
  
  Neurogastroenterology and Motility
  
  Volume: 25 Issue: 2 Pages: 190-197
- DOI
  10.1111/nmo.12050
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590252, KAKENHI-PROJECT-23650202, KAKENHI-PROJECT-25290001
[Journal Article] Water-avoidance stress enhances gastric contractions in freely moving conscious rats: role of peripheral CRF receptors. J2013
- Author(s)
  Tsukasa Nozu, Shima Kumei, Kaoru Takakusaki, Toshikatsu Okumura
- Journal Title
  
  Journal of Gastroenterology
  
  Volume: 48 Issue: 5 Pages: 1-7
- DOI
  10.1007/s00535-013-0828-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23650202, KAKENHI-PROJECT-25290001
[Journal Article] Peripheral corticotropin-releasing factor (CRF) induces stimulation of gastric contractions in freely moving conscious rats : role of CRF receptor types 1 and 22013
- Author(s)
  Nozu T, Tsuchiya Y, Kumei S, Takakusaki K, Okumura T
- Journal Title
  
  Neurogastroenterol. Motil
  
  Volume: 25 Pages: 190-197
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590252
[Journal Article] Water-avoidance stress enhances gastric contractions in freely moving conscious rats : role of peripheral CRF receptors2013
- Author(s)
  Nozu T, Kumei S, Takakusaki K, Okumura T
- Journal Title
  
  J. Gastroenterol
  
  Volume: (in press)
- NAID
  120006658779
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590252
[Journal Article] IL-1 receptor antagonist blocks the lipopolysaccharide-induced inhibition of gastric motility in freely moving conscious rats2012
- Author(s)
  Tsuchiya Y, Nozu T, Kumei S, Ohhira M, Okumura T
- Journal Title
  
  Dig. Dis. Sci
  
  Volume: 57 Pages: 2555-61
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590252
[Journal Article] IL-1 receptor antagonist blocks thelipopolysaccharide-induced inhibition ofgastric motility in freely movingconscious rats2012
- Author(s)
  Tsuchiya Y, Nozu T, Kumei S, Ohhira M, Okumura T.
- Journal Title
  
  Dig Dis Sci
  
  Volume: 57(10) Pages: 2555-61
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659391
[Journal Article] Endogenous orexin-A in the brain mediates 2-deoxy-D-glucose-induced stimulation of gastric motility in freely moving conscious rats2012
- Author(s)
  Nozu T, Tuchiya Y, Kumei S, Takakusaki K, Ataka K, Fujimiya M, Okumura T
- Journal Title
  
  J. Gastroenterol
  
  Volume: 47 Pages: 404-411
- NAID
  10030650004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590252
[Journal Article] IL-1 receptor antagonist blocks the lipopolysaccharide-induced inhibition of gastric motility in freely moving conscious rats.2012
- Author(s)
  Tsuchiya Y, Nozu T, Kumei S, Ohhira M, Okumura T.
- Journal Title
  
  Dig Dis Sci.
  
  Volume: Oct;57(10) Pages: 2555-61
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659391
[Journal Article] IL-1 receptor antagonist blocks the lipopolysaccharide-induced inhibition of gastric motility in freely moving conscious rats.2012
- Author(s)
  Tsuchiya Y, Nozu T, Kumei S, Ohhira M, Okumura T.
- Journal Title
  
  Digestive Diseases and Sciences
  
  Volume: 57 Issue: 10 Pages: 2555-2561
- DOI
  10.1007/s10620-012-2210-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590252
[Journal Article] Endogenous orexin-A in the brain mediates 2-deoxy-D-glucose-induced stimulation of gastric motility in freely moving conscious rats.2012
- Author(s)
  Nozu T, Tuchiya Y, Kumei S, Takakusaki K, Ataka K, Fujimiya M, Okumura T.
- Journal Title
  
  Journal of Gastroenterology
  
  Volume: 47 Issue: 4 Pages: 404-411
- DOI
  10.1007/s00535-011-0506-7
- NAID
  10030650004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590252, KAKENHI-PROJECT-23650202
[Journal Article] Central orexin-A increases colonic motility in conscious rats2011
- Author(s)
  Nozu T, Kumei S, Takakusaki K, Ataka K, Fujimiya M, Okumura T
- Journal Title
  
  Neurosci. Lett
  
  Volume: 498 Pages: 143-6
- NAID
  120004461833
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590252
[Presentation] apelinは内臓知覚過敏と腸管バリアの傷害を誘導し過敏性腸症候群の病態に関与する2024
- Author(s)
  野津　司
- Organizer
  第51回日本潰瘍学会
- Data Source
  KAKENHI-PROJECT-22K08790
[Presentation] lovastatinはIBSモデルの内臓知覚過敏・腸管透過性亢進を抑制する2023
- Author(s)
  野津　司
- Organizer
  第25回日本神経消化器病学会
- Data Source
  KAKENHI-PROJECT-22K08790
[Presentation] IBSの病態と脳内AdenosineA2Bシグナル2022
- Author(s)
  石王応知, 野津司, 奥村利勝
- Organizer
  第108回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-21K07883
[Presentation] 脳内Adenosine A2B 受容体の活性化はGhrelinによる迷走神経を介する腸管バリア改善に関与する。2021
- Author(s)
  石王応知, 野津司, 五十嵐将, 田邊裕貴, 粂井志麻, 大平賀子, 高草木薫, 奥村利勝
- Organizer
  第23回日本神経消化器病学会
- Data Source
  KAKENHI-PROJECT-21K07883
[Presentation] Ghrelinは中枢神経に作用して迷走神経を介して腸管バリア機能改善作用を有する2021
- Author(s)
  石王応知, 野津司, 奥村利勝
- Organizer
  第48回日本潰瘍学会
- Data Source
  KAKENHI-PROJECT-21K07883
[Presentation] Dehydroepiandrosterone sulfateはラット過敏性腸症候群モデルの内臓知覚過敏，腸管透過性亢進を抑制する2020
- Author(s)
  野津　司
- Organizer
  第47回日本潰瘍学会／第21回日本神経消化器病学会
- Data Source
  KAKENHI-PROJECT-18K07896
[Presentation] ストレスによる内臓知覚，腸管透過性の変化-末梢corticotropin-releasing factorの役割と過敏性腸症候群2019
- Author(s)
  野津　司
- Organizer
  日本消化器病学会週間2019
- Data Source
  KAKENHI-PROJECT-18K07896
[Presentation] Glucagon-like peptide-1アナログ，リラグルチドの内臓知覚と腸管透過性に対する効果について2018
- Author(s)
  野津　司
- Organizer
  第 14 回日本消化管学会総会学術集会
- Data Source
  KAKENHI-PROJECT-26460287
[Presentation] Repeated water avoidance stress induces visceral hypersensitivity; role of IL-1, IL-6 and peripheral corticotropin-releasing factor2017
- Author(s)
  T. Nozu, T. Okumura
- Organizer
  ANMA & JSNM Joint Meeting 2017
- Place of Presentation
  大阪
- Year and Date
  2017-03-23
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460287
[Presentation] ストレス，CRF，過敏性腸症候群2017
- Author(s)
  野津　司
- Organizer
  第72回日本大腸肛門病学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-26460287
[Presentation] Water avoidance stress induces visceral hyposensitivity through peripheral corticotropin releasing factor receptor type 2 and central dopamine D2 receptor in rats2017
- Author(s)
  T. Nozu, T. Okumura
- Organizer
  ANMA & JSNM Joint Meeting 2017
- Place of Presentation
  大阪
- Year and Date
  2017-03-23
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460287
[Presentation] 消化管運動と内臓知覚における末梢CRF受容体サブタイプの役割－balance theoryについて2015
- Author(s)
  野津　司，奥村　利勝
- Organizer
  日本神経消化器病学会
- Place of Presentation
  沖縄
- Year and Date
  2015-11-12
- Data Source
  KAKENHI-PROJECT-26460287
[Presentation] 末梢CRFと胃運動-FDの病態生理との関連について2013
- Author(s)
  野津司,奥村利勝
- Organizer
  日本消化器病学会ワークショップ12機能性ディスペプシア-診断と治療の現況を巡って-
- Place of Presentation
  東京
- Year and Date
  2013-10-11
- Data Source
  KAKENHI-PROJECT-23590252
[Presentation] 基底核-脳幹投射系による歩行と筋緊張の制御　=運動細胞内記録の成績=2013
- Author(s)
  高草木薫，野津司，奥村利勝
- Organizer
  第93回生理学会北海道地方会
- Place of Presentation
  旭川
- Data Source
  KAKENHI-PROJECT-25290001
[Presentation] Inhibition of corticotropin releasing factor (CRF) receptor type 2 signaling enhances peripheral CRF-induced stimulation of colonic contractions in conscious rats2013
- Author(s)
  Tsukasa Nozu, Toshikatsu Okumura
- Organizer
  米国消化器病学会
- Place of Presentation
  Orlando, Fla, USA
- Data Source
  KAKENHI-PROJECT-23590252
[Presentation] Modulation of the excitability of hindlimb motoneurons by the basal ganglia efferents to the brainstem in relation to the control of postural muscle tone and locomotion in the decerebrate cat2013
- Author(s)
  Takakusaki K, Nozu T, Okumura T
- Organizer
  Society for Neuroscience 2013
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-25290001
[Presentation] Inhibition of corticotropin releasing factor (CRF) receptor type 2 signaling enhances peripheral CRF-induced stimulation of colonic contractions in conscious rats2013
- Author(s)
  Tsukasa Nozu, Toshikatsu Okumura
- Organizer
  Digestive Disease Week
- Place of Presentation
  Orlando, Fla, USA
- Data Source
  KAKENHI-PROJECT-23590252
[Presentation] IBSの基礎と臨床2012
- Author(s)
  野津　司
- Organizer
  日本消化管学会(招待講演)
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-23590252
[Presentation] オレキシンと消化管運動2012
- Author(s)
  野津司,奥村利勝
- Organizer
  日本消化器病学会
- Place of Presentation
  神戸
- Year and Date
  2012-10-10
- Data Source
  KAKENHI-PROJECT-23590252
[Presentation] プライマリ・ケアを受診する機能性ディスペプシア患者の臨床的検討-大学病院との比較2011
- Author(s)
  野津　司
- Organizer
  日本消化器病学会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23590252
[Presentation] オレキシン-Aは中枢神経系に作用して意識下ラットの大腸運動を促進する2011
- Author(s)
  野津　司
- Organizer
  神経消化器病学会
- Place of Presentation
  宇都宮
- Data Source
  KAKENHI-PROJECT-23590252
[Presentation] Spinal interneuronal organization involved in the control of postural muscle tone in the cat
- Author(s)
  Takakusaki K, Chiba R, Obara K, Nozu T, Okumura T.
- Organizer
  Society for Neuroscience Annual Meeting (SFN 2014)
- Place of Presentation
  Washington DC, USA
- Year and Date
  2014-11-15 – 2014-11-19
- Data Source
  KAKENHI-PROJECT-25290001
[Presentation] Peripheral corticotropin-releasing factor (CRF) induces stimulation of colonic contractions and visceral hyperalgesia in rats; role of CRF receptor type 1 and 2
- Author(s)
  Tsukasa Nozu, Toshikatsu Okumura
- Organizer
  Japan Digestive Disease Week 2014
- Place of Presentation
  神戸
- Year and Date
  2014-10-23 – 2014-10-26
- Data Source
  KAKENHI-PROJECT-26460287
[Presentation] 末梢CRFと胃運動－FDの病態生理との関連について
- Author(s)
  野津　司，奥村利勝
- Organizer
  日本消化器病学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23590252

1. OKUMURA Toshikatsu (60281903)

# of Collaborated Projects: 11 results

# of Collaborated Products: 66 results
2. TAKAKUSAKI Kaoru (10206732)

# of Collaborated Projects: 5 results

# of Collaborated Products: 24 results
3. KUMEI Shima (00548969)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
4. Ishioh Masatomo (50869211)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
5. OHHIRA Masumi (30447106)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. OBARA Kazuhiro (40548749)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. FUNAKOSHI Hiroshi (40273685)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. KOBAYASHI Kazuto (90211903)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. Miyagishi Saori

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
10. 進藤基博

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

NOZU Tsukasa 野津 司

野津 司 ノヅ ツカサ

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腹部手術後イレウスと術後せん妄に対する新規治療法の探究Principal Investigator

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Exploring novel therapies on the basis of pathophysiological commonality between irritable bowel syndrome and metabolic syndromePrincipal Investigator

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Roles of LPS, cytokine and peripheral CRF receptors on gastrointestinal functionPrincipal Investigator

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The role and the mechanisms of orexin in modulating gastrointestinal functionPrincipal Investigator

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消化管機能異常症の病態生理に関する神経内分泌学的検討Principal Investigator

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[Journal Article] Brain Neuropeptides, Neuroinflammation, and Irritable Bowel Syndrome2024

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NOZU Tsukasa 野津司

野津司ノヅツカサ