YAMAKUNI Tohru 山國徹

… Alternative Names

山国徹ヤマクニトオル

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Researcher Number	30333793
Other IDs
Affiliation (based on the past Project Information) *help	2010: 東北大学, 大学院・薬学研究科, 准教授 2009: Tohoku University, 薬学研究科, 准教授 2008: Tohoku University, 大学院・薬学研究科, 准教授 2007: 東北大学大学院, 薬学研究科, 准教授 2002 – 2005: 東北大学, 大学院・薬学研究科, 助教授
Review Section/Research Field	Principal Investigator Biological pharmacy / Neurochemistry/Neuropharmacology Except Principal Investigator Biological Sciences / Biological pharmacy / Science and Engineering
Keywords	Principal Investigator CapZ / V-1 / CNS neurodegeneration / Regeneratin of brain function / Neurogenesis / TH gene / Transcriptional regulation / Actin dynamics / neurosphere / 蛋白質相互作用 … More / 天然ハーブエキス / 脳神経幹細胞 / 神経再生 / 神経機能制御 / アクチンフィラメント形成 / レトロウイルスベクター / 中枢神経変性疾患 / 脳機能再生 / 神経新生 / TH遺伝子 / 転写制御 / アクチンダイナミックス / 脳神経疾患 / 移植・再生医療 / 発現制御 / ドパミンの生合成 / siRNA / 転写 / F-アクチンの形成促進 / 新規発現制御メカニズム / チロシン水酸化酵素 / 精神・神経疾患の病態と治療 … More Except Principal Investigator 薬用植物成分 / 真菌由来化合物 / アポトーシス / 抗がん剤 / 細胞骨格 / Akt / 放線菌由来化合物 / Ca^<2+>-ATPase / PKA / C1チャネル / ホスホエステラーゼ / cAMP / アラキドン酸 / カチオンチャネル / VDCC / プロスタノイド / 平滑筋収縮 / ホスホジエステラーゼ / 平滑筋 / 喘息 / 天然生理活性物質 / 細胞内情報伝達 / 薬理学 / 血管新生阻害 / HSP90 / PI3キナーゼ / 海洋天然物 / スカブロニンGメチルエステル / スカブロニンG / カノコジオール / ホスホリパーゼC / PC12D細胞 / 神経成長因子 / MAPキナーゼ / ピクロシド / β-ユーデスモール / 神経細胞分化 Less

Elucidation of novel molecular regulatory mechanisms underlying tyrosine hydroxylase functional expression and development of therapeutics for the CNS neurodegenerative disordersPrincipal Investigator
- Principal Investigator
  
  YAMAKUNI Tohru
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Tohoku University
Basic research for finding the mechanism of paradox appeared in Controlling asthma
- Principal Investigator
  
  SAITO Shin-ya
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  University of Shizuoka
新しい医薬資源からの抗がん性物質の探索と分子標的の解明
- Principal Investigator
  
  大泉康
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
Elucidation of physiological significance of a novel regulator of neuronal functions and its application to functional regeneration of brainPrincipal Investigator
- Principal Investigator
  
  YAMAKUNI Tohru
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Tohoku University
新しい医薬資源からの抗がん性物質の分子標的の解明
- Principal Investigator
  
  大泉康
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
新しい医薬資源からの抗腫瘍性天然物の探索とその分子標的の解明
- Principal Investigator
  
  大泉康
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
神経細胞の分化を制御する微量天然生理活性物質の探索およびその作用解析
- Principal Investigator
  
  OHIZUMI Yasushi
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  Tohoku University

All 2011 2010 2009 2008 2007 2006 2005 2004 Other

All Journal Article Presentation Book

[Book] 日本薬理学会実験薬理学シリーズ第1巻「創薬、育薬、病態解明のための実践行動薬理学」(分担執筆)「陳皮成分nobiletinの抗認知症作用の行動薬理学的証明と機能性食品開発への応用」pp191-1972010
- Author(s)
  山國徹
- Publisher
  金芳堂
- Data Source
  KAKENHI-PROJECT-20500331
[Book] 日本薬理学会実験薬理学シリーズ第1巻「創薬、育薬、病態解明のための実践行動薬理学」
- Author(s)
  山國徹, 中島晶, 大泉康
- Publisher
  金芳堂
- Data Source
  KAKENHI-PROJECT-20500331
[Journal Article] Shishihakuhito, a traditional Chinese medicine for atopic dermatitis, suppresses NGF-induced neurite extension by inhibition of MEK/ERK signaling in PC12D cells.2011
- Author(s)
  Nakanishi K, Kawahata I, Sun W, Wang Y, Yoshida M, Ohizumi Y and Yamakuni T.
- Journal Title
  
  J. Trad. Med.
  
  Volume: 28 Pages: 16-21
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20500331
[Journal Article] Two distinct mechanisms for actin capping protein regulation. steric and allosteric inhibition.2010
- Author(s)
  Takeda T, Minakata S, Kawahata I, Kitazawa M, Koike R, Narita A, Ota M, Yamakuni T, Maeda Y, and Nitanai Y.
- Journal Title
  
  PLoS Biology
  
  Volume: 8(7)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20500331
[Journal Article] アミロイドβペプチドの凝集・毒性発現の分子メカニズムの解明と低分子化合物による阻害:アルツハイマー病の克服に向けて2010
- Author(s)
  山國徹
- Journal Title
  
  薬学雑誌
  
  Volume: 130 Pages: 493-494
- NAID
  130000259536
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20500331
[Journal Article] 陳皮の抗認知症成分ノビレチンによるアミロイドβペプチド(Aβ)の神経毒性発現抑制とAβ誘発性記憶障害改善2010
- Author(s)
  山國徹, 等
- Journal Title
  
  薬学雑誌
  
  Volume: 130 Pages: 517-520
- NAID
  130000259540
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20500331
[Journal Article] アミロイドβペプチドの凝集・毒性発現の分子メカニズムの解明と低分子化合物による阻害2010
- Author(s)
  山國徹
- Journal Title
  
  アルツハイマー病の克服に向けて薬学雑誌
  
  Volume: 130 Pages: 493-494
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20500331
[Journal Article] Dual effects of nobiletin, a citrus polymethoxy flavone, on catecholamine secretion in cultured bovine adrenal medullary cells.2010
- Author(s)
  Zhang H, Toyohira Y, Ueno S, Shinohara Y, Itoh H, Furuno Y, Yamakuni T, Tsutsumi M, Takahashi K and Yanagihara N
- Journal Title
  
  J. Neurochem.
  
  Volume: 114 Pages: 1030-1038
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20500331
[Journal Article] 陳皮の抗認知症成分ノビレチンによるアミロイドβペプチド(A.)の神経毒性発現抑制とA.2010
- Author(s)
  山國徹、中島晶、大泉康
- Journal Title
  
  誘発性記憶障害改善薬学雑誌
  
  Volume: 130 Pages: 517-520
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20500331
[Journal Article] V-1, a Positive Regulator of Tyrosine Hydroxylase Gene Expression, Promotes Maitotoxin-and Palytoxin-induced Norepinephrine Secretion in PC12D Cells2010
- Author(s)
  Kakizaki A, Oka N, Tachikawa E, Miyate Y, Takahashi K, Yamamoto T, Taira E, Ohizumi Y, and Yamakuni T
- Journal Title
  
  Pharmacometric
  
  Volume: 78 Pages: 67-71
- NAID
  10029055398
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20500331
[Journal Article]2010
- Author(s)
  山國徹, 中島晶, 大泉康
- Journal Title
  
  日本薬理学会実験薬理学シリーズ第1巻「創薬、育薬、病態解明のための実践行動薬理学」分担執筆「陳皮成分 nobiletin の抗認知症作用の行動薬理学的証明と機能性食品開発への応用」(金芳堂)
- Data Source
  KAKENHI-PROJECT-20500331
[Journal Article] Nobiletin improves brain ischemia-induced learning and memory deficits through stimulation of CaMKII and CREB phosphorylation.2009
- Author(s)
  Yamamoto Y., Shioda N., Han F., Moriguchi S., Nakajima A., Yokosuka A., Mimaki Y., Sashida Y., Yamakuni T., Ohizumi Y. & Fukunaga K.
- Journal Title
  
  Brain Res.
  
  Volume: 1292 Pages: 218-229
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20500331
[Journal Article] Neurobehavioral effects of tetrabromobisphenol A, a brominated flame retardant, in mice.2009
- Author(s)
  Nakajima A., Saigusa D., Tetsu N., Yamakuni T., Tomioka Y. & Hishinuma T.
- Journal Title
  
  Toxicol. Lett.
  
  Volume: 189 Pages: 78-83
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20500331
[Journal Article] Search for Herbal Extracts with the Activity to Stimulate Tyrosine Hydroxylase Gene Transcription in PC12D Cells.2009
- Author(s)
  Tagaya S, Suetake Y, Yoshida K, Shimura S, Ohizumi Y and Yamakuni T.
- Journal Title
  
  Pharmacometrics
  
  Volume: 77 Pages: 131-135
- NAID
  10028212169
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20500331
[Journal Article] Shishihakuhito, a traditional Chinese medicine for atopic dermatitis, inhibits IgE-mediated histamine release from rat RBL-2H3 basophilic leukocyte cells2009
- Author(s)
  Wakabayashi M., Sakurai E., Yanai K., Umemura K., Yoshida M., Ohizumi Y., Yamakuni T.
- Journal Title
  
  J. Trad. Med 26
  
  Pages: 44-49
- NAID
  110007137398
- Data Source
  KAKENHI-PROJECT-19590055
[Journal Article] 4'-Demethlynobiletin, a bioactive metabolite of nobiletin enhancing PKA/ERK/CREB signaling, rescues learning impairment associated with NMDA receptor antagonism via stimulation of the ERK cascade.2009
- Author(s)
  Md. Al Rahim, Nakajima A., Saigusa D., Tetsu N., Maruyama Y., Shibuya, M., Yamakoshi H., Tomioka Y., Iwabuchi Y. Ohizumi Y. & Yamakuni T.
- Journal Title
  
  Biochemistry
  
  Volume: 48 Pages: 7713-7721
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20500331
[Journal Article] Shishihakuhito, a traditional Chinese medicine for atopic dermatitis, inhibits IgE-mediated histamine release from rat RBL-2H3 basophilic leukocyte cells.2009
- Author(s)
  Wakabayashi M., Sakurai E., Yanai K., Umemura K., Yoshida M., Ohizumi Y. & Yamakuni T.
- Journal Title
  
  J. Trad. Med.
  
  Volume: 26 Pages: 44-49
- NAID
  110007137398
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20500331
[Journal Article] A novel diol-derivative of chalcone produced by bioconversion, 3-(2, 3-dihydroxyphenyl)-1-phenylpropan-1-one, activates PKA/MEK/ERK signaling and antagonizes A.-inhibition of the cascade in cultured rat CNS neurons.2008
- Author(s)
  Md. Al Rahim, Nakajima A, Misawa N, Shindo K, Adachi K, Shizuri Y, Ohizumi Y & Yamakuni T.
- Journal Title
  
  Eur. J. Pharmacol
  
  Volume: 600 Pages: 10-17
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20500331
[Journal Article] Nobiletin, a citrus flavonoid with neurotrophic action, augments protein kinase A-mediated phosphorylation of the AMPA receptor subunit, GluR1, and the postsynaptic receptor response to glutamate in murine hippocampus.2008
- Author(s)
  Matsuzaki, K., Miyazaki, K., Sakai, S., Yawo, H., Nakata, N., Moriguchi, S., Fukunaga, K., Yokosuka, A., Sashida, Y., Mimaki, Y., Yamakuni T. & Yasushi Ohizumi, Y.
- Journal Title
  
  Eur. J. Pharmacol
  
  Volume: 578 Pages: 194-200
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20500331
[Journal Article] Nobiletin, a citrus flavonoid with neurotrophic action, augments protein kinase A-mediated phosphorylation of the AMPA receptor subunit, GluR1, and the postsynaptic receptor response to glutamate in murine hippocampus2008
- Author(s)
  Matsuzaki K., Miyazaki K., Sakai S., Yawo H., Nakata N., Moriguchi S., Fukunaga K., Yokosuka A., Sashida Y., Mimaki Y., Yamakuni T., Ohizumi Y.
- Journal Title
  
  Eur J Pharmacol 578
  
  Pages: 194-200
- Data Source
  KAKENHI-PROJECT-19590055
[Journal Article] Nobiletin, a citrus flavonoid, improves memory impairment and A. pathology in a transgenic mouse model of Alzheimer's disease.2008
- Author(s)
  Onozuka H, Nakajima A, Matsuzaki K, Shin RW, Ogino K, Saigusa D, Tetsu N, Yokosuka A, Sashida Y, Mimaki Y, Yamakuni T & Ohizumi Y
- Journal Title
  
  J. Pharmacol. Exp. Ther.
  
  Volume: 326 Pages: 739-744
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20500331
[Journal Article] Nobiletin, a citrus flavonoid, reverses learning impairment associated with NMDA receptor antagonism by activation of ERK signaling2007
- Author(s)
  Nakajima A., Yamakuni T., Matsuzaki K., Nakata N., Onozuka H., Yokosuka A., Sashida Y., Yoshihiro Mimaki Y., Ohizumi Y.
- Journal Title
  
  J. Pharmacol. Exp. Ther 321
  
  Pages: 784-790
- Data Source
  KAKENHI-PROJECT-19590055
[Journal Article] Nobiletin restoring β-amyloid-impaired CREB phosphorylation rescues memory deterioration in Alzheimer's disease model rats2006
- Author(s)
  K.Matsuzaki, T.Yamakuni et al.
- Journal Title
  
  Neurosci. Lett. 400
  
  Pages: 230-234
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590041
[Journal Article] PKA-dependent signaling regulates CapZ by promoting its dissociation from V-1 with anti-capping activity in PC12D cells2006
- Author(s)
  M.Kitazawa, M., T.Yamakuni et al.
- Journal Title
  
  Journal of Biological Chemistry (印刷中)
- Data Source
  KAKENHI-PROJECT-16590041
[Journal Article] V-1 enhances PMA-induced activation of NF-κB-dependent transcription in PC12D cells2006
- Author(s)
  Y.Hiwatashi, T.Yamakuni et al.
- Journal Title
  
  Pharmacometrics 70
  
  Pages: 17-20
- NAID
  10020344516
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590041
[Journal Article] Proinsulin C-peptide stimulates a PKC/IκB/NF-κB signaling pathway2006
- Author(s)
  M.Kitazawa, T.Yamakuni et al.
- Journal Title
  
  J. Biochem. (印刷中)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590041
[Journal Article] Garcinone B reduces prostaglandin E_2 release and NF-κB-mediated transcription in C6 rat glioma cells.2006
- Author(s)
  T.Yamakuni, Y.Ohizumi et al.
- Journal Title
  
  Neuroscience Letters (印刷中)
- Data Source
  KAKENHI-PROJECT-16590041
[Journal Article] Garcinone B reduces prostaglandin E2 release and NF-κB-mediated transcription in C6 cells2006
- Author(s)
  T.Yamakuni, K.Aoki et al.
- Journal Title
  
  Neurosci. Lett. 394
  
  Pages: 206-210
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590041
[Journal Article] Nobiletin restoring β-amyloid-impaired CREB phosphorylation rescues memory deterioration in Alzheimer's disease model rats2006
- Author(s)
  Matsuzaki, K., Yamakuni, T., Hashimoto, M., Haque, A.M., Shido, O., Mimaki, Y., Sashida, Y., Ohizumi, Y.
- Journal Title
  
  Neurosci.Lett. 400
  
  Pages: 230-234
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590041
[Journal Article] Garcinone B reduces prostaglandin E_2 release and NF-κB-mediated transcription in C_6 cells.2006
- Author(s)
  Yamakuni, T., Aoki, K., Nakatani, K., Kondo, N., Oku, H., Ishiguro, K., Ohizumi, Y.
- Journal Title
  
  Neurosci.Lett. 394
  
  Pages: 206-210
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590041
[Journal Article] V-1 enhances PMA-induced activation of NF-κB-dependent transcription in PC12D cells.2006
- Author(s)
  Hiwatashi, Y., Yamakuni, T., Ohizumi, Y.
- Journal Title
  
  Pharmacometrics 70
  
  Pages: 17-20
- NAID
  10020344516
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590041
[Journal Article] Nobiletin restoring β-amyloid-impaired CREB phosphorylation rescues memory deterioration in Alzheimer's disease model rats2006
- Author(s)
  K.Matsuzaki, T.Yamakuni et al.
- Journal Title
  
  Neuroscience Letters (印刷中)
- Data Source
  KAKENHI-PROJECT-16590041
[Journal Article] Intracellular cAMP controls a physical association of V-1 with CapZ in cultured mammalian endocrine cells2005
- Author(s)
  M.Kitazawa, M., T.Yamakuni et al.
- Journal Title
  
  Biochemical and Biophysical Research. Communications 331
  
  Pages: 181-186
- Data Source
  KAKENHI-PROJECT-16590041
[Journal Article] Target for new drug development-a novel regulatory factor of catecholamine synthesis2005
- Author(s)
  Yamakuni, T.
- Journal Title
  
  Pharmacometrics 69
  
  Pages: 89-94
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590041
[Journal Article] Nobiletin and its related flavonoids with CRE-dependent transcription-stimulating and neuritegenic activities2005
- Author(s)
  H.Nagase, T.Yamakuni et al.
- Journal Title
  
  Biochem. Biophys. Res. Commun. 377
  
  Pages: 1330-1336
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590041
[Journal Article] Nobiletin and its related flavonoids with CRE-dependent transcription-stimulating and neuritegenic activities.2005
- Author(s)
  H.Nagase, T.Yamakuni et al.
- Journal Title
  
  Biochemical and Biophysical Research. Communications 377
  
  Pages: 1330-1336
- Data Source
  KAKENHI-PROJECT-16590041
[Journal Article] Ephedorae herba decreases lipopolysaccharide-induced cyclooxgenase-2 protein expression and NF-κB-dependent transcription in C6 rat glioma cells.2005
- Author(s)
  Aoki, K., Yamakuni, T., Yoshida, M., Ohizumi, Y.
- Journal Title
  
  J.Pharmacol.Sci. 98
  
  Pages: 327-330
- NAID
  10025729227
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590041
[Journal Article] Intracellular cAMP controls a physical association of V-1 with Cap Z in cultured mammalian endocrine cells.2005
- Author(s)
  Kitazawa, M., Yamakuni, T., Song, S.-Y., Kato, C., Tsuchiya, R., Ishida, M., Suzuki, N., Adachi, E., Iwashita, S., Ueno, S., Yanagihara, N., Taoka, M., Isobe, T., Ohizumi, Y.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 331
  
  Pages: 181-186
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590041
[Journal Article] Intracellular cAMP controls a physical association of V-1 with Cap Z in cultured mammalian endocrine cells2005
- Author(s)
  M.Kitazawa, T.Yamakuni et al.
- Journal Title
  
  Biochem. Biophys. Res. Commun. 331
  
  Pages: 181-186
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590041
[Journal Article] Mechanism of neurotropic action of nobiletin in PC12D cells2005
- Author(s)
  H.Nagase, T.Yamakuni et al.
- Journal Title
  
  Biochemistry 44
  
  Pages: 13683-13691
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590041
[Journal Article] Nobiletin and its related flavonoids with CRE-dependent transcription- stimulating and neuritegenic activities.2005
- Author(s)
  Nagase, H., Omae, N., Omori, A., Nakagawasai, O., Tadano, T., Yokosuka, A., Sashida, Y., Mimaki, Y., Yamakuni, T., Ohizumi, Y.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 377
  
  Pages: 1330-1336
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590041
[Journal Article] 新たな創薬研究のターゲット-新規カテコラミン合成制御因子 V-12005
- Author(s)
  山國徹
- Journal Title
  
  応用薬理 69
  
  Pages: 89-94
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590041
[Journal Article] Ephedorae herba decreases lipopolysaccharide-induced cyclooxgenase-2 protein expression and NF-κB-dependent transcription in C6 rat glioma cells2005
- Author(s)
  K.Aoki, T.Yamakuni et al.
- Journal Title
  
  J. Pharmacol. Sci. 98
  
  Pages: 327-330
- NAID
  10025729227
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590041
[Journal Article] Mechanism of neurotropic action of nobiletin in PC12D cells.2005
- Author(s)
  Nagase, H., Yamakuni, T., Matsuzaki, K., Maruyama, Y., Kasahara, J., Fukunaga, K., Hinohara, Y., Kondo, S., Mimaki, Y., Sashida, Y., Tank, A.W., Ohizumi, Y.
- Journal Title
  
  Biochemistry 44
  
  Pages: 13683-13691
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590041
[Journal Article] Evidence for the involvement of protein kinase C in acidic pH-induced contraction in spontaneously hypertensive rat aorta2004
- Author(s)
  D.K.Rohra, T.Yamakuni et al.
- Journal Title
  
  Pharmacology 71
  
  Pages: 10-16
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590041
[Journal Article] γ-Mangostin inhibits IκB kinase activity and decreases lipopolysaccharide-induced cyclooxygenase-2 gene expression in C6 rat glioma cells.2004
- Author(s)
  K.Nakatani, T.Yamakuni et al.
- Journal Title
  
  Molecular Pharmacology 66
  
  Pages: 667-674
- Data Source
  KAKENHI-PROJECT-16590041
[Journal Article] IC101 induces apotosis by Akt dephosphorylation via an inhibition of heat shock protein 90-ATP binding activity accompanied by preventing the interaction with Akt in L12210 cells2004
- Author(s)
  H.Fujiwara, T.Yamakuni et al.
- Journal Title
  
  J. Pharmacol. Exp. Ther. 310
  
  Pages: 1288-1295
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590041
[Journal Article] IC101 induces apoptosis by akt dephosphorylation via an inhibition of heat shock protein 90-ATP binding activity accompanied by preventing the interaction with akt in L1210 cells.2004
- Author(s)
  H.Fujiwara, T.Yamakuni et al.
- Journal Title
  
  Journal of Pharmacology and Experimental Therapeutics 310
  
  Pages: 1288-1295
- Data Source
  KAKENHI-PROJECT-16590041
[Journal Article] IC101 induces apotosis by Akt dephosphorylation via an inhibition of heat shock protein 90-ATP binding activity accompanied by preventing the interaction with Akt in L1210 cells.2004
- Author(s)
  Fujiwara, H., Yamakuni, T., Ueno, M., Ishizuka, M., Shinkawa, T., Isobe, T., Ohizumi, Y.
- Journal Title
  
  J.Pharmacol.Exp.Ther. 310
  
  Pages: 1288-1295
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590041
[Journal Article] Potent antioxidative activity of unripe fruits of Garcinia mangostana L.2004
- Author(s)
  J.Feng, T.Yamakuni, et al.
- Journal Title
  
  Natural Medicines 58
  
  Pages: 156-159
- NAID
  80016842507
- Data Source
  KAKENHI-PROJECT-16590041
[Journal Article] Potent antioxidative activity of unripe fruits of Garcinia mangostana L2004
- Author(s)
  J.Feng, T.Yamakuni et al.
- Journal Title
  
  Natural Medicines, 58
  
  Pages: 156-159
- NAID
  80016842507
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590041
[Journal Article] Acidosis-induced protein tyrosine phosphorylation depends on Ca~<2+> influx via voltage-dependent Ca~<2+> channels in SHR aorta2004
- Author(s)
  D.K.Rohra, T.Yamakuni et al.
- Journal Title
  
  Eur. J. Pharmacol. 504
  
  Pages: 105-111
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590041
[Journal Article] _Y-Mangostin inhibits inhibitor-κB kinase activity and decreases lipopolysaccharide-induced cyclooxygenase-2 gene expression in C6 rat glioma cells.2004
- Author(s)
  Nakatani, K., Yamakuni, T., Kondo, N., Arakawa, T., Oosawa, K., Shimura, S., Ohizumi, Y.
- Journal Title
  
  Mol.Pharmacol. 66
  
  Pages: 667-674
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590041
[Journal Article] γ-Mangostin inhibits inhibitor-κB kinase activity and decreases lipopolysaccharide-induced cyclooxygenase-2 gene expression in C6 rat glioma cells2004
- Author(s)
  K.Nakatani, T.Yamakuni et al.
- Journal Title
  
  Mol. Pharmacol. 66
  
  Pages: 667-674
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590041
[Journal Article] Potent antioxidative activity of unripe fruits of Garcinia mangostana L.2004
- Author(s)
  Feng.J., Yamakuni, T., Katoh, E., Hosoda, S., Ohizumi, Y.
- Journal Title
  
  Natural Medicines 58
  
  Pages: 156-159
- NAID
  80016842507
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590041
[Journal Article] Acidosis-induced protein tyrosine phosphorylation depends on Ca^<2+> influx via voltage-dependent Ca^<2+> channels in SHR aorta.2004
- Author(s)
  Rohra, D.K., Yamakuni, T., Ohizumi, Y.
- Journal Title
  
  Eur.J.Pharmacol. 504
  
  Pages: 105-111
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590041
[Journal Article] Evidence for the involvement of protein kinase C in acidic pH-induced contraction in spontaneously hypertensive rat aorta.2004
- Author(s)
  Rohra, D.K., Yamakuni, T., Ito, S., Saito, S., Ohizumi, Y.
- Journal Title
  
  Pharmacology 71
  
  Pages: 10-16
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590041
[Journal Article] Intracellular cAMP controls a physical association of V-1 with CapZ in cultured mammalian endocrine cells
- Author(s)
  M.Kitazawa, M., T.Yamakuni, et al.
- Journal Title
  
  Biochemical and Biophysical Research. Communications (印刷中)
- Data Source
  KAKENHI-PROJECT-16590041
[Journal Article] Proinsulin C-peptide stimulates a PKC/Iκ B/NF-κ B signaling pathway
- Author(s)
  Kitazawa, M., Shibata, Y., Hashimoto, S., Ohizumi, Y., T., Yamakuni
- Journal Title
  
  J.Biochemi. (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590041
[Presentation] 新規アクチンダイナミックスの制御因子V-1/CapZ複合体によるチロシン水酸化酵素の発現制御機構2011
- Author(s)
  川畑伊知郎、森田淳一、山國徹
- Organizer
  第84回日本薬理学会年会
- Place of Presentation
  横浜
- Year and Date
  2011-03-23
- Data Source
  KAKENHI-PROJECT-20500331
[Presentation] CapZを介したチロシン水酸化酵素遺伝子発現の新規調節メカニズムの解析2010
- Author(s)
  森田淳一、金京梅、中島晶、阿部誠也、山岸祐輔、陳嘉春、大泉康、富岡佳久、山國徹
- Organizer
  第130回日本薬学会年会
- Place of Presentation
  岡山
- Year and Date
  2010-03-28
- Data Source
  KAKENHI-PROJECT-20500331
[Presentation] ノビレチンの抗アルツハイマー病活性を薬効基盤とする漢方薬・陳皮による認知症克服へのアプローチ2010
- Author(s)
  山國徹
- Organizer
  第31回和漢医薬学総合研究所特別セミナー(招待講演)
- Place of Presentation
  富山
- Year and Date
  2010-10-22
- Data Source
  KAKENHI-PROJECT-20500331
[Presentation] ノビレチンの抗アルツハイマー病活性を薬効基盤とする漢方薬・陳皮による認知症克服へのアプローチ2010
- Author(s)
  山國徹
- Organizer
  第31回和漢医薬学総合研究所特別セミナー
- Place of Presentation
  富山(招待講演)
- Year and Date
  2010-10-22
- Data Source
  KAKENHI-PROJECT-20500331
[Presentation] V-1/CapZによるアクチンダイナミックスの制御機構とチロシン水酸化酵素の発現調節の関連性2010
- Author(s)
  川畑伊知郎、森田淳一、山國徹
- Organizer
  第49回日本薬学会東北支部大会
- Place of Presentation
  郡山
- Year and Date
  2010-10-24
- Data Source
  KAKENHI-PROJECT-20500331
[Presentation] チロシン水酸化酵素遺伝子発現調節機構におけるAnkリピートを持つ新規促進因子V-1の作用メカニズムの生化学的・分子生物学的解析2009
- Author(s)
  森田淳一、中島晶、阿部誠也、山岸祐輔、金京梅、陳嘉春、大泉康、富岡佳久、山國徹
- Organizer
  第48回日本薬学会東北支部会大会
- Place of Presentation
  仙台
- Year and Date
  2009-10-18
- Data Source
  KAKENHI-PROJECT-20500331
[Presentation] 柑橘類の新しい機能性の発見-in vivo実験による柑橘類成分ノビレチンの抗認知症作用の証明2009
- Author(s)
  山國徹
- Organizer
  第3回In vivo実験医学シンポジウム
- Place of Presentation
  東京
- Year and Date
  2009-12-09
- Data Source
  KAKENHI-PROJECT-20500331
[Presentation] 陳皮の抗認知症成分ノビレチンによるアミロイドβペプチド(Aβ)の神経毒性発現抑制とAβ誘発性記憶障害改善2009
- Author(s)
  山國徹
- Organizer
  第129回日本薬学年会シンポジウム
- Place of Presentation
  京都
- Year and Date
  2009-03-27
- Data Source
  KAKENHI-PROJECT-20500331

1. SAITO Shin-ya (80271849)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
2. OHIZUMI Yasushi (00006355)

# of Collaborated Projects: 5 results

# of Collaborated Products: 14 results
3. 李玉山 (50344685)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. NAKAHATA Norimichi (60045804)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. KAKIZAKI Atsushi (70458173)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. NAKAJIMA Akira (20419237)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 斎藤真也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

YAMAKUNI Tohru 山國 徹

山国 徹 ヤマクニ トオル

Research Projects

Research Products

Co-Researchers

Elucidation of novel molecular regulatory mechanisms underlying tyrosine hydroxylase functional expression and development of therapeutics for the CNS neurodegenerative disordersPrincipal Investigator

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Basic research for finding the mechanism of paradox appeared in Controlling asthma

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新しい医薬資源からの抗がん性物質の探索と分子標的の解明

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Review Section

Research Institution

Elucidation of physiological significance of a novel regulator of neuronal functions and its application to functional regeneration of brainPrincipal Investigator

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新しい医薬資源からの抗がん性物質の分子標的の解明

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Research Institution

新しい医薬資源からの抗腫瘍性天然物の探索とその分子標的の解明

Principal Investigator

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Research Institution

神経細胞の分化を制御する微量天然生理活性物質の探索およびその作用解析

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Research Institution

[Book] 日本薬理学会実験薬理学シリーズ第1巻「創薬、育薬、病態解明のための実践行動薬理学」(分担執筆)「陳皮成分nobiletinの抗認知症作用の行動薬理学的証明と機能性食品開発への応用」pp191-1972010

Author(s)

Publisher

Data Source

[Book] 日本薬理学会実験薬理学シリーズ第1巻「創薬、育薬、病態解明のための実践行動薬理学」

Author(s)

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Data Source

[Journal Article] Shishihakuhito, a traditional Chinese medicine for atopic dermatitis, suppresses NGF-induced neurite extension by inhibition of MEK/ERK signaling in PC12D cells.2011

Author(s)

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[Journal Article] Two distinct mechanisms for actin capping protein regulation. steric and allosteric inhibition.2010

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[Journal Article] アミロイドβペプチドの凝集・毒性発現の分子メカニズムの解明と低分子化合物による阻害:アルツハイマー病の克服に向けて2010

Author(s)

Journal Title

NAID

Data Source

[Journal Article] 陳皮の抗認知症成分ノビレチンによるアミロイドβペプチド(Aβ)の神経毒性発現抑制とAβ誘発性記憶障害改善2010

Author(s)

Journal Title

NAID

Data Source

[Journal Article] アミロイドβペプチドの凝集・毒性発現の分子メカニズムの解明と低分子化合物による阻害2010

Author(s)

Journal Title

Data Source

[Journal Article] Dual effects of nobiletin, a citrus polymethoxy flavone, on catecholamine secretion in cultured bovine adrenal medullary cells.2010

Author(s)

Journal Title

YAMAKUNI Tohru 山國徹

山国徹ヤマクニトオル