KANZAKI Hiroyuki 菅崎弘幸

Researcher Number	30333826
Other IDs	https://orcid.org/0000-0003-3473-1218
External Links
Affiliation (Current)	2019: 鶴見大学, 歯学部, 准教授
Affiliation (based on the past Project Information) *help	2016 – 2019: 鶴見大学, 歯学部, 准教授 2014 – 2015: 鶴見大学, 歯学部, 講師 2012 – 2013: 東北大学, 大学病院, 助教 2011: 東北大学, 病院, 助教 2007: Tohoku University Hospital, 病院, Assistant Professor 2005 – 2006: 東北大学, 病院, 助手 2004 – 2006: 東北大学, 病院・助手
Review Section/Research Field	Principal Investigator Orthodontic/Pediatric dentistry / Surgical dentistry / Orthodontics/Pediatric dentistry Except Principal Investigator Orthodontics/Pediatric dentistry / Basic Section 57070:Developmental dentistry-related / Orthodontic/Pediatric dentistry
Keywords	Principal Investigator サイトカイン / Nrf2 / メカニカルストレス / TACE / 破骨細胞 / 腫瘍細胞 / エピジェネティクス / 骨代謝 / 歯周組織 / ADAM17 … More Except Principal Investigator 歯根膜 / 骨吸収 / 歯周組織 / 骨芽細胞 / 破骨細胞 / メカニカルストレス / 骨形成 / 歯根膜細胞 / Mechanical stress / エピジェネティクス / H3K9 metyltransferases / アルカリフォスファターゼ / H3k9me2 / H3k9me3 / Osteoblasts / サイトカイン / Remodeling / 遺伝子導入 / 骨改造 / Periodontal ligament cells / アポトーシス / マイクロRNA / BMP-4 / 歯科矯正学的歯の移動 / エレクトロポレーション / シグナル伝達 / 歯肉 / 超音波 / RANKL / Periodontal tissue / リン酸 / 矯正学的歯の移動 / 血管新生因子 / H3K9 / Glp / G9a / H3k9me1 / リモデリング / Gene transfer / Osteoclasts / Bone Morphogenetic Protein / 歯根膜線維芽細胞 / OPG / 歯の移動 / 歯槽骨 / Orthodontic tooth movement Less

ALP活性に依存するリン酸による歯根膜線維芽細胞の分化機序に関する基礎研究Ongoing
- Principal Investigator
  
  石川美佐緒
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57070:Developmental dentistry-related
- Research Institution
  Tsurumi University
下顎頭軟骨の特異性における抗酸化ストレス能のエピジェネティック制御Principal InvestigatorOngoing
- Principal Investigator
  
  菅崎弘幸
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Orthodontics/Pediatric dentistry
- Research Institution
  Tsurumi University
Elucidation of the epigenetically regulation of the phenotype of the periodontal ligament fibroblast
- Principal Investigator
  
  Yoshiki Nakamura
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthodontics/Pediatric dentistry
- Research Institution
  Tsurumi University
Elucidation of the microRNA-mediated control of the alveolar bone metabolism by PDL cells under each mechanical stresses
- Principal Investigator
  
  Noda Koji
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthodontics/Pediatric dentistry
- Research Institution
  Tsurumi University
Elucidation of pro-metastatic property of interferon degradationPrincipal Investigator
- Principal Investigator
  
  KANZAKI Hiroyuki
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Surgical dentistry
- Research Institution
  Tsurumi University
  Tohoku University
Exprolation of regulatory mechanisms of root resorption by immune cellsPrincipal Investigator
- Principal Investigator
  
  KANZAKI Hiroyuki
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Orthodontic/Pediatric dentistry
- Research Institution
  Tohoku University
咀嚼筋への局所的遺伝子導入法を用いた筋機能改善とそれに伴う骨格性開咬の阻止Principal Investigator
- Principal Investigator
  
  菅崎弘幸
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Orthodontic/Pediatric dentistry
- Research Institution
  Tohoku University
Analysis of periodontal tissue remodeling mechanism induced by mechanical stress and the regulation by gene transfer
- Principal Investigator
  
  CHIBA Mirei
- Project Period (FY)
  2004 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Orthodontic/Pediatric dentistry
- Research Institution
  Tohoku University

All 2018 2017 2016 2015 2014 2013 2012 2008 2007 2006 2005 2004 Other

All Journal Article Presentation

[Journal Article] Dimethyl fumarate inhibits osteoclasts via attenuation of reactive oxygen species signalling by augmented antioxidation.2018
- Author(s)
  Yamaguchi Y, Kanzaki H, Katsumata Y, Itohiya K, Fukaya S, Miyamoto Y, Narimiya T, Wada S, Nakamura Y
- Journal Title
  
  J Cell Mol Med.
  
  Volume: 22 Pages: 1138-1147
- DOI
  10.1111/jcmm.13367
- Open Access / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K11797, KAKENHI-PROJECT-16H05552, KAKENHI-PROJECT-15K11356, KAKENHI-PROJECT-15K11376
[Journal Article] Novel device for application of continuous mechanical tensile strain to mammalian cells.2017
- Author(s)
  Wada, Satoshi Kanzaki, Hiroyuki Narimiya, Tsuyoshi Nakamura, Yoshiki
- Journal Title
  
  Biology Open.
  
  Volume: 6 Pages: 518-524
- DOI
  10.1242/bio.023671
- Open Access / Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K11376, KAKENHI-PROJECT-16K11797, KAKENHI-PROJECT-15K11356
[Journal Article] Possible alternative treatment for mandibular asymmetry by local unilateral IGF-1 injection into the mandibular condylar cavity: Experimental study in mice2017
- Author(s)
  Fukaya S, Kanzaki H, Miyamoto Y, Yamaguchi Y, Nakamura Y.
- Journal Title
  
  American Journal of Orthodontics and Dentofacial Orthopedics
  
  Volume: 152(6) Pages: 820-829
- DOI
  10.1016/j.ajodo.2017.05.023
- Open Access / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05552, KAKENHI-PROJECT-15K11356, KAKENHI-PROJECT-15K11376
[Journal Article] RANKL induces Bach1 nuclear import and attenuates Nrf2-mediated antioxidant enzymes, thereby augmenting intracellular reactive oxygen species signaling and osteoclastogenesis in mice2017
- Author(s)
  Kanzaki H, Shinohara F, Itohiya K, Yamaguchi Y, Katsumata Y, Matsuzawa M, Fukaya S, Miyamoto Y, Wada S, Nakamura Y
- Journal Title
  
  The FASEB Journal
  
  Volume: 31 Pages: 781-792
- DOI
  10.1096/fj.201600826r
- Open Access / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K11797, KAKENHI-PROJECT-16H05552, KAKENHI-PROJECT-15K11356, KAKENHI-PROJECT-15K11376
[Journal Article] Orthodontic tensile strain induces angiogenesis via type iv collagen degradation by matrix metalloproteinase-12.2017
- Author(s)
  Narimiya, T. Wada, S. Kanzaki, H. Ishikawa, M. Tsuge, A. Yamaguchi, Y. Nakamura, Y.
- Journal Title
  
  Journal of periodontal research
  
  Volume: 印刷中 Pages: 1-11
- DOI
  10.1111/jre.12453
- Open Access / Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K11376, KAKENHI-PROJECT-16K11797, KAKENHI-PROJECT-16H05552, KAKENHI-PROJECT-15K11356
[Journal Article] Asporin stably expressed in the surface layer of mandibular condylar cartilage and augmented in the deeper layer with age.2017
- Author(s)
  Miyamoto Y, Kanzaki H, Wada S, Tsuruoka S, Itohiya K, Kumagai K, Hamada Y, Nakamura Y
- Journal Title
  
  Bone reports
  
  Volume: 7 Pages: 41-50
- DOI
  10.1016/j.bonr.2017.07.002
- Open Access / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K11797, KAKENHI-PROJECT-15K11356, KAKENHI-PROJECT-15K11376
[Journal Article] Asporin stably expressed in the surface layer of mandibular condylar cartilage and augmented in the deeper layer with age.2017
- Author(s)
  Miyamoto Y, Kanzaki H, Wada S, Tsuruoka S, Itohiya K, Kumagai K, Hamada Y, Nakamura Y.
- Journal Title
  
  Bone reports
  
  Volume: 7 Pages: 41-50
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05552
[Journal Article] Novel device for application of continuous mechanical tensile strain to mammalian cells.2017
- Author(s)
  Wada S, Kanzaki H, Narimiya T, Nakamura Y.
- Journal Title
  
  Biology Open.
  
  Volume: 6(4) Pages: 518-524
- Open Access / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05552
[Journal Article] Molecular regulatory mechanisms of osteoclastogenesis through cytoprotective enzymes.2016
- Author(s)
  Kanzaki, H. Shinohara, F. Kanako, I. Yamaguchi, Y. Fukaya, S. Miyamoto, Y. Wada, S. Nakamura, Y.
- Journal Title
  
  Redox Biol
  
  Volume: 8 Pages: 186-191
- DOI
  10.1016/j.redox.2016.01.006
- Open Access / Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K11376, KAKENHI-PROJECT-26462825, KAKENHI-PROJECT-15K11356, KAKENHI-PROJECT-16K11797
[Journal Article] A-Disintegrin and Metalloproteinase (ADAM) 17 Enzymatically Degrades Interferon-gamma.2016
- Author(s)
  Kanzaki H., Shinohara F., Suzuki M., Wada S., Miyamoto Y., Yamaguchi Y., Katsumata Y., Makihira S., Kawai T., Taubman MA, Nakamura Y.
- Journal Title
  
  Sci Rep
  
  Volume: 30
- DOI
  10.1038/srep32259
- Open Access / Int'l Joint Research / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K11356, KAKENHI-PROJECT-16K11797
[Journal Article] The main occluding area in normal occlusion and mandibular prognathism2016
- Author(s)
  Kurokawa M., Kanzaki H., Tokiwa H., Handa H., Nakaoka K., Hamada Y., Kato H., Nakamura Y
- Journal Title
  
  Angle Orthod
  
  Volume: 86(1) Pages: 87-93
- DOI
  10.2319/111114-807.1
- Open Access / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K11356
[Journal Article] Occlusal hypofunction mediates alveolar bone apposition via relative augmentation of TGF-β signaling by decreased Asporin production in rats.2016
- Author(s)
  Kanako Itohiya Hiroyuki Kanzaki Misao Ishikawa Satoshi Wada Yutaka Miyamoto Tsuyoshi Narimiya Yoshiki Nakamura
- Journal Title
  
  Dental, Oral and Craniofacial Research
  
  Volume: 3 Pages: 1-8
- DOI
  10.15761/docr.1000192
- Open Access / Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K11376
[Journal Article] Evaluation of antibacterial activity of visible light-responsive TiO2-based photocatalyst coating on orthodontic materials against cariogenic bacteria2016
- Author(s)
  Sudo T., Imai S., Ochiai T., Kanzaki H., Morita Y., Hanada N., Nakamura Y.
- Journal Title
  
  Asian Pac J Dent
  
  Volume: 16 Pages: 15-22
- Open Access / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K11356
[Journal Article] Nrf2 Activation Attenuates Both Orthodontic Tooth2015
- Author(s)
  Kanzaki, H., Shinohara, F., Kajiya, M., Fukaya, S., Miyamoto, Y., & Nakamura, Y.
- Journal Title
  
  Journal of Dental Research.
  
  Volume: in press
- Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25670841
[Journal Article] Nrf2 activation attenuates both orthodontic tooth movement and relapse.2015
- Author(s)
  Kanzaki H, Shinohara F, Itohiya-Kasuya K, Ishikawa M, Nakamura Y.
- Journal Title
  
  J Dent Res
  
  Volume: 94 Pages: 787-794
- DOI
  10.1177/0022034515577814
- Open Access / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K11356
[Journal Article] 細胞膜透遃性ペプチド7R-ETGEによる骨破壊性疾患の阻止2014
- Author(s)
  菅崎弘幸、篠原文明、加治屋幹人、小玉哲也
- Journal Title
  
  第26回バイオエンジニアリング講演会プロシーディング
  
  Volume: 13-69 Pages: 253-254
- Data Source
  KAKENHI-PROJECT-23689081
[Journal Article] Nuclear nrf2 induction by protein transduction attenuates osteoclastogenesis2014
- Author(s)
  Kanzaki, H. Shinohara, F. Kajiya, M. Fukaya, S. Miyamoto, Y. Nakamura, Y.
- Journal Title
  
  Free Radic Biol Med
  
  Volume: 77 Pages: 239-248
- DOI
  10.1016/j.freeradbiomed.2014.09.006
- Open Access / Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25670841
[Journal Article] The Keap1/Nrf2 Protein A xis Plays a Role in Osteoclast Differen tiation by Regulating Intracellular Rea ctive Oxygen Species Signaling2013
- Author(s)
  H Kanzaki, F Shinohara, M Kajiya, T kodama
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 32 Pages: 23009-20
- DOI
  10.1074/jbc.m113.478545
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592954, KAKENHI-PROJECT-23689081
[Journal Article] HVJ-E/importin-bet a hybrid vector for overcoming cytoplas mic and nuclear membranes as double bar rier for non-viral gene delivery2012
- Author(s)
  Takeshi Kawazu, Hiroyuki Kanzaki, Atsushi Uno, Hideki Azuma, and Takeshi Nagasaki
- Journal Title
  
  Biome dicine & pharmacotherapy
  
  Volume: 66 Pages: 519-524
- DOI
  10.1016/j.biopha.2012.02.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500544, KAKENHI-PROJECT-23689081, KAKENHI-PUBLICLY-23107527
[Journal Article] Local osteoprotegerin gene transfer inhibits relapse of orthodontic tooth movement2012
- Author(s)
  Zhao, N.; Lin, J.; Kanzaki, H.; Ni, J.; Chen, Z.; Liang, W.; Liu, Y
- Journal Title
  
  American journal of orthodontics and de ntofacial orthopedics
  
  Volume: 141 Pages: 30-40
- DOI
  10.1016/j.ajodo.2011.06.035
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23689081
[Journal Article] HVJ-E/importin- β hybrid vector for overcoming cytoplasmic and nuclear membranes as double barrier for non-viral gene delivery.2012
- Author(s)
  T Kawazu, H Kanzaki, A Uno, H Azuma, and T Nagasaki.
- Journal Title
  
  Biomed Pharmacother
  
  Volume: 66(7) Pages: 519-24
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23689081
[Journal Article] Effects of local osteoprotegerin gene transfection on orthodontic root resorption during retention : an in vivo Micro-CT analysis.2012
- Author(s)
  N Zhao, Y Liu, H Kanzaki, W Liang, J Ni, J Lin.
- Journal Title
  
  Orthod Craniofac Res
  
  Volume: 15 Pages: 10-20
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23689081
[Journal Article] Effects of local o steoprotegerin gene transfection on ort hodontic root resorption during retenti on : an in vivo micro-CT analysis2012
- Author(s)
  Zhao, N.; Liu, Y.; Kanzaki, H.; Liang, W.; Ni, J.; Lin, J
- Journal Title
  
  Ortho dontics & craniofacial research
  
  Volume: 15 Pages: 10-20
- DOI
  10.1111/j.1601-6343.2011.01532.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23689081
[Journal Article] Inhibiti on of T-Cell-Mediated and Infection-Ind uced Periodontal Bone Resorption by TAC E Blockade2012
- Author(s)
  Kanzaki, H.; Han, X.; Asami, Y.; Suzu ki, M.; Kawai, T.; Taubman, M
- Journal Title
  
  In : Sasaki, K.; Suzuki, O.; Takahashi, N., eds. Interface Oral Hea lth Science 2011: Springer Japan
  
  Pages: 173-175
- DOI
  10.1007/978-4-431-54070-0_45
- Data Source
  KAKENHI-PROJECT-23689081
[Journal Article] Local osteoprotegerin gene transfer to periodontal tissue inhibits lipopolysaccharide-induced alveolar bone resorption.2008
- Author(s)
  Chen R, Kanzaki H, Chiba M, Nishimura M, Kanzaki R, Igarashi K.
- Journal Title
  
  J Periodontal Res. 43
  
  Pages: 237-245
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16390602
[Journal Article] Local osteoprotegerin gene transfer to periodontal tissue inhibits lipopolysaccharide-induced alveolar bone resorption.2007
- Author(s)
  Chen R, Kanzaki H, Chiba M, Nishimura M, Kanzaki R, Igarashi K.
- Journal Title
  
  J Periodontal Res 43(2):
  
  Pages: 237-245
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16390602
[Journal Article] Local osteoprotegerin gene transfer to periodontal tissue inhibits lipopolysaccharide-induced alveolar bone resoption2007
- Author(s)
  Chen R, Kanzaki H, Chiba M, Nishimura M, Kanzaki R, Igarashi K.
- Journal Title
  
  J Periodontal Res 43(2)
  
  Pages: 237-245
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390602
[Journal Article] Clodronate inhibits PGE(2) production in compressed periodontal ligament cells.2006
- Author(s)
  Liu L, Igarashi K, Kanzaki H, Chiba M, Shinoda H, Mitani H.
- Journal Title
  
  J Dent Res 85(8):
  
  Pages: 757-760
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16390602
[Journal Article] Local RANKL gene transfer to the periodontal tissue accelerates orthodontic tooth movement2006
- Author(s)
  Kanzaki H, Chiba M, Arai K, Takahashi I, Haruyama N, Nishimura M, Mitani H.
- Journal Title
  
  Gene Ther 13(8)
  
  Pages: 678-685
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390602
[Journal Article] Tension to PDL inhibited OC-genesis through OPG induction2006
- Author(s)
  Kanzaki H
- Journal Title
  
  Journal of Dental Research (印刷中)
- Data Source
  KAKENHI-PROJECT-16390602
[Journal Article] Local RANKL gene transfer to the periodontal tissue accelerates orthodontic tooth movement.2006
- Author(s)
  Kanzaki H, Chiba M, Arai K, Takahashi I, Haruyama N, Nishimura M, Mitani H
- Journal Title
  
  Gene Ther 13・8
  
  Pages: 678-685
- Data Source
  KAKENHI-PROJECT-16390602
[Journal Article] Clodronate inhibits PGE(2) production in compressed periodontal ligament cells.2006
- Author(s)
  Liu L, Igarashi K, Kanzaki H, Chiba M, Shinoda H, Mitani H
- Journal Title
  
  J Dent Res 85・8
  
  Pages: 757-760
- Data Source
  KAKENHI-PROJECT-16390602
[Journal Article] Local RANHL gene transfer to the periodontal tissue accelerates orthodontic tooth movement.2006
- Author(s)
  Kanzaki H, Chiba M, Arai K, Takahashi I, Haruyama N, Nishimura M, Mitani H.
- Journal Title
  
  Gene Ther. ;13(8):
  
  Pages: 678-685
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16390602
[Journal Article] Cyclical tensile force on periodontal ligament cells inhibits osteoclastogenesis through OPG induction.2006
- Author(s)
  Kanzaki H, Chiba M, Sato A, Miyagawa A, Arai K, Nukatsuka S, Mitani H
- Journal Title
  
  J Dent Res 85・5
  
  Pages: 457-462
- Data Source
  KAKENHI-PROJECT-16390602
[Journal Article] Local RANKL gene transfer to the periodontal tissue accelerates orthodontic tooth movement2006
- Author(s)
  Kanzaki H
- Journal Title
  
  Gene Therapy 13・8
  
  Pages: 678-685
- Data Source
  KAKENHI-PROJECT-16390602
[Journal Article] メカニカルストレス受容歯根膜細胞による破骨細胞分化誘導制御2006
- Author(s)
  千葉美麗, 菅崎弘幸, 松本千登勢, 糖塚世毅
- Journal Title
  
  日本実験力学会講演論文集 6
  
  Pages: 151-153
- Data Source
  KAKENHI-PROJECT-16390602
[Journal Article] Cyclical tensile force on periodontal ligament cells inhibits osteoclastogenesis through OPG induction2006
- Author(s)
  Kanzaki H, Chiba M, Sato A, Miyagawa A, Arai K, Nukatsuka S, Mitani H.
- Journal Title
  
  J Dent Res 85(5):
  
  Pages: 457-462
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16390602
[Journal Article] Cyclical tensile for ce on periodontal ligameng cells inhibits osteoclastogenesis through OPG induction2006
- Author(s)
  Kanzaki H, Chiba M, Sato A, Miyagawa A, Arai K, Nukatsuka S, Mitani H.
- Journal Title
  
  J Dent Res 85(5)
  
  Pages: 457-462
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390602
[Journal Article] Clodronate inhibits PGE(2) production in compressed periodontal liament cells2006
- Author(s)
  Liu L, Igarashi K, Kanzaki H, Chiba M, Shinoda H, Mitani H.
- Journal Title
  
  J Dent Res 85(8)
  
  Pages: 757-760
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390602
[Journal Article] Local OPG gene transfer to periodontal tissue inhibits orthodontic tooth movement2004
- Author(s)
  H.Kanzaki
- Journal Title
  
  Journal of Dental Research 83
  
  Pages: 920-925
- Data Source
  KAKENHI-PROJECT-16390602
[Journal Article] Local OPG gene transfer to periodontal tissue inhibits orthodontic tooth movement2004
- Author(s)
  Kanzaki H, Chiba M, Takahashi I, Haruyama N, Nishimura M, Mitani H.
- Journal Title
  
  J Dent res 83(12)
  
  Pages: 920-925
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390602
[Journal Article] Local OPG gene transfer to periodontal tissue inhibits orthodontic tooth movement.2004
- Author(s)
  Kanzaki H, Chiba M, Takahashi I, Haruyama N, Nishimura M, Mitani H.
- Journal Title
  
  J Dent Res 83(12):
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16390602
[Presentation] 矯正学的歯の移動とHMGB1　アップデートシンポジウム5「核内タンパク質HMGB1」2017
- Author(s)
  菅崎弘幸、中村芳樹
- Organizer
  歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-15K11376
[Presentation] Asporinは咬合機能低下に伴う新生歯槽骨添加における制御因子である2016
- Author(s)
  糸日谷佳菜子、菅崎弘幸、石川美佐緒、下田信治、中村芳樹
- Organizer
  第75回日本矯正歯科学会
- Place of Presentation
  アスティ徳島(徳島県徳島市)
- Year and Date
  2016-11-07
- Data Source
  KAKENHI-PROJECT-15K11356
[Presentation] マウスへのmyo-inositol　栄養補充による下顎骨の成長促進2016
- Author(s)
  山口祐樹、菅崎弘幸、宮本　豊、糸日谷佳菜子、深谷紗吏、勝又裕太、中村芳樹
- Organizer
  第75回日本矯正歯科学会
- Place of Presentation
  アスティ徳島(徳島県徳島市)
- Year and Date
  2016-11-07
- Data Source
  KAKENHI-PROJECT-15K11356
[Presentation] MMP12は矯正学的歯の移動時の牽引側歯根膜組織における血管網再構築に重要な役割を果たしている2016
- Author(s)
  成宮　毅、和田悟史、菅崎弘幸、中村芳樹
- Organizer
  第75回日本矯正歯科学会
- Place of Presentation
  アスティ徳島(徳島県徳島市)
- Year and Date
  2016-11-07
- Data Source
  KAKENHI-PROJECT-15K11356
[Presentation] IGF-1の顎関節局所投与による下顎骨非対称に対する治療の可能性2015
- Author(s)
  深谷紗吏　菅崎弘幸　宮本　豊　山口祐希　中村芳樹
- Organizer
  第74回日本矯正歯科学会
- Place of Presentation
  福岡国際会議場(福岡市)
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-15K11356
[Presentation] Asporinは咬合機能低下に伴う歯根膜腔狭窄の制御因子である2015
- Author(s)
  糸日谷　佳菜子、菅崎　弘幸、石川　美佐緒、下田　信治、中村　芳樹
- Organizer
  第74回日本矯正歯科学会
- Place of Presentation
  福岡国際会議場(福岡市）
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-15K11356
[Presentation] Bach1 nuclear export attenuates osteoclastogenesis and osteoclast activation via inhibition of intracellular ROS signaling.2015
- Author(s)
  Hiroyuki Kanzaki, Fumiaki Shinohara, Masazumi Matsuzawa, and Yoshiki Nakamura
- Organizer
  American Society for Bone and Mineral Research 2015 Annual Meeting
- Place of Presentation
  Washington State Convention Centor, Seattle, Washington, USA
- Year and Date
  2015-10-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K11356
[Presentation] Nrf2を介した抗郿化ストレス都素群発現は破骨細胞分化を負に制御する2014
- Author(s)
  菅崎弘幸、篠原文明、加治屋幹人
- Organizer
  第35回東北骨代謝・骨粗鬆症研究会
- Place of Presentation
  仙台
- Year and Date
  2014-02-01
- Data Source
  KAKENHI-PROJECT-23689081
[Presentation] 細胞膜透遃性ペプチド7R-ETGEによる骨破壊性疾患の阻止2014
- Author(s)
  菅崎弘幸、篠原文明、加治屋幹人、小玉哲也
- Organizer
  第26回バイオエンジニアリング講演会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-23689081
[Presentation] Nrf2 negatively regulates osteoclast differentiation.2012
- Author(s)
  H Kanzaki, M Kajiya, T Kodama
- Organizer
  国際歯科研究学会
- Place of Presentation
  フォスドイグアス、ブラジル
- Data Source
  KAKENHI-PROJECT-23689081
[Presentation] TNF-alpha converting enzyme degradates interferon-gamma2012
- Author(s)
  Hiroyuki Kanzaki, Mirei Chiba, Maiko Suzuki, Toshi Kawai, and Martin Taubman
- Organizer
  アメリカ免疫学会
- Place of Presentation
  ボストン(アメリカ合衆国)
- Data Source
  KAKENHI-PROJECT-23689081
[Presentation] Nrf2 negatively regulates osteoclast differentiation2012
- Author(s)
  Hiroyuki Kanzaki, Mikihito Kajiya, and Tetsuya Kodama
- Organizer
  国際歯科研究学会
- Place of Presentation
  フォスドイグアス(ブラジル)
- Data Source
  KAKENHI-PROJECT-23689081
[Presentation] TNF-alpha Converting Enzyme Degradates Interferon-Gamma.2012
- Author(s)
  Hiroyuki Kanzaki, Mirei Chiba, Maiko Suzuki, Toshi Kawai, and Martin Taubman
- Organizer
  アメリカ免疫学会
- Place of Presentation
  ボストン、アメリカ合衆国
- Data Source
  KAKENHI-PROJECT-23689081
[Presentation] LPS Induces Alveolar Bone Resorption by Stimulating RANKL Expression2007
- Author(s)
  R. CHEN, M. CHIBA, H. KANZAKI, and K. IGARASHI
- Organizer
  The IADR/AADR/CADR 85th General Session and Exhibition
- Place of Presentation
  New Orleans, LA, USA.
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390602
[Presentation] 歯周組織のリモデリングを制御する歯根膜細胞のバイオメカニクス2007
- Author(s)
  千葉美麗, 五賀優子, 菅崎弘幸, 山本照子
- Organizer
  第46回日本生体医工学会
- Place of Presentation
  仙台国際センター
- Year and Date
  2007-04-25
- Data Source
  KAKENHI-PROJECT-16390602
[Presentation] Retentive effects of local OPG-gene transfer on tooth movement2006
- Author(s)
  K. ARAI, KANZAKI, and M. CHIBA
- Organizer
  The IADR 84th General Session & Exhibition
- Place of Presentation
  Brisbane, Australia
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390602
[Presentation] TACE regulate inert-osteoclastogenesis in tensile-side of orthodontic-tooth-movement by RANKL-modification2006
- Author(s)
  H. KANZAKI, M. CHIBA, and K. ARAI
- Organizer
  The IADR 84th General Session & Exhibition
- Place of Presentation
  Brisbane, Australia
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390602
[Presentation] TACE regulated inert-osteoclastogenesis in tensile-side of orthodontic-tooth-movement by RANKL-modification2006
- Author(s)
  H. KANZAKI, M. CHIBA, and K. ARAI
- Organizer
  The IADR General Session & Exhibition
- Place of Presentation
  Brisbane, Australia
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390602
[Presentation] Mechanically stimulated periodontal ligament cells inhibit osteoclastogenesis via soluble factor(s)2005
- Author(s)
  M. CHIBA, S. NUKATSUKA and H. KANZAKI
- Organizer
  The IADR/AADR/CADR 83rd General Session
- Place of Presentation
  Baltimore, MD, USA
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390602
[Presentation] Mechanically stimulated periodontal ligament cells inhibit osteoclastogenesis via soluble factor (s)2005
- Author(s)
  M. CHIBA, S. NUKATSUKA and H. KANZAKI
- Organizer
  The IADR/AADR/CADR 83rd General Session & Exhibition
- Place of Presentation
  Baltimore, MD, USA
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390602
[Presentation] RANKL-sheddase Increased by Tension but not by Compression in PDL-cells2005
- Author(s)
  H. KANZAKI, M. CHIBA, and K. IGARASHI
- Organizer
  The LADR/AADR/CADR 83rd General Session & Exhibition
- Place of Presentation
  Baltimore, MD, USA
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390602
[Presentation] In vivo site-specific gene transfer targeting periodontal ligament2005
- Author(s)
  M. CHIBA, S. TSUCHIYA, and H. KANZAKI
- Organizer
  The IADR/AADR/CADR 83rd General Session & Exhibition
- Place of Presentation
  Baltimore, MD, USA
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390602
[Presentation] Chemical Bach1 inhibition attenuates osteoclastogenesis.
- Author(s)
  Hiroyuki Kanzaki1, 2, Fumiaki Shinohara3, Masazumi Matsuzawa1, and Yoshiki Nakamura1
- Organizer
  IADR
- Place of Presentation
  Hynes Convention Center （Boston, MA, USA)
- Year and Date
  2015-03-11 – 2015-03-14
- Data Source
  KAKENHI-PROJECT-25670841
[Presentation] Nrf2活性化による抗酸化ストレス酵素群発現誘導は破骨細胞分化阻害を介して歯の移動を抑制する
- Author(s)
  菅崎弘幸、篠原文明、中村芳樹
- Organizer
  日本矯正歯科学会
- Place of Presentation
  幕張メッセ（千葉、幕張）
- Year and Date
  2014-10-20 – 2014-10-22
- Data Source
  KAKENHI-PROJECT-25670841

1. Yoshiki Nakamura (10097321)

# of Collaborated Projects: 3 results

# of Collaborated Products: 21 results
2. 和田悟史 (20581119)

# of Collaborated Projects: 3 results

# of Collaborated Products: 11 results
3. 石川美佐緒 (90582445)

# of Collaborated Projects: 3 results

# of Collaborated Products: 5 results
4. Noda Koji (10148059)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 宮本豊 (00633588)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. SHINOHARA Fumiaki (80400258)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
7. CHIBA Mirei (10236820)

# of Collaborated Projects: 1 results

# of Collaborated Products: 24 results
8. IGARASHI Kaoru (70202851)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
9. 新井千博 (10460221)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 高野吉郎 (90126425)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 下田信治 (30139620)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. AZUMA Hideki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 長崎健

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KANZAKI Hiroyuki 菅崎 弘幸

Research Projects

Research Products

Co-Researchers

ALP活性に依存するリン酸による歯根膜線維芽細胞の分化機序に関する基礎研究Ongoing

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下顎頭軟骨の特異性における抗酸化ストレス能のエピジェネティック制御Principal InvestigatorOngoing

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Elucidation of the epigenetically regulation of the phenotype of the periodontal ligament fibroblast

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Elucidation of the microRNA-mediated control of the alveolar bone metabolism by PDL cells under each mechanical stresses

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Elucidation of pro-metastatic property of interferon degradationPrincipal Investigator

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Exprolation of regulatory mechanisms of root resorption by immune cellsPrincipal Investigator

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咀嚼筋への局所的遺伝子導入法を用いた筋機能改善とそれに伴う骨格性開咬の阻止Principal Investigator

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Analysis of periodontal tissue remodeling mechanism induced by mechanical stress and the regulation by gene transfer

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[Journal Article] Dimethyl fumarate inhibits osteoclasts via attenuation of reactive oxygen species signalling by augmented antioxidation.2018

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[Journal Article] Novel device for application of continuous mechanical tensile strain to mammalian cells.2017

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[Journal Article] Possible alternative treatment for mandibular asymmetry by local unilateral IGF-1 injection into the mandibular condylar cavity: Experimental study in mice2017

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[Journal Article] RANKL induces Bach1 nuclear import and attenuates Nrf2-mediated antioxidant enzymes, thereby augmenting intracellular reactive oxygen species signaling and osteoclastogenesis in mice2017

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[Journal Article] Orthodontic tensile strain induces angiogenesis via type iv collagen degradation by matrix metalloproteinase-12.2017

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[Journal Article] Asporin stably expressed in the surface layer of mandibular condylar cartilage and augmented in the deeper layer with age.2017

Author(s)

Journal Title

KANZAKI Hiroyuki 菅崎弘幸