HASHIMOTO TADAFUMI 橋本唯史

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HASHIMOTO Tadafumi 橋本唯史

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Researcher Number	30334337
Other IDs
Affiliation (Current)	2025: 国立研究開発法人国立精神・神経医療研究センター, 神経研究所疾病研究第四部, 部長
Affiliation (based on the past Project Information) *help	2021 – 2024: 国立研究開発法人国立精神・神経医療研究センター, 神経研究所疾病研究第四部, 部長 2016 – 2022: 東京大学, 大学院医学系研究科(医学部), 特任准教授 2017: 東京大学, 医学(系)研究科(研究院), 助教 2017: 東京大学, 医学(系)研究科(研究院), 特任准教授 2015: 東京大学, 医学(系)研究科(研究院), 講師 … More 2014: 東京大学, 医学(系)研究科(研究院), 助教 2013 – 2014: 東京大学, 大学院医学系研究科, 特任講師 2012 – 2013: 東京大学, 医学(系)研究科(研究院), 特任講師 2008: The University of Tokyo, 大学院・医学系研究科, 助教 2007: The University of Tokyo, 大学院・薬学研究科, 助教 2007: The University of Tokyo, Graduate School of Pharmaceutical Sciences, Assistant Professor 2006: 東京大学, 大学院薬学系研究科, 助手 2003 – 2005: 東京大学, 大学院・薬学系研究科, 助手 Less
Review Section/Research Field	Principal Investigator Biological pharmacy / Basic Section 51030:Pathophysiologic neuroscience-related / Medium-sized Section 51:Brain sciences and related fields / Biological Sciences / Pathological medical chemistry / Nerve anatomy/Neuropathology Except Principal Investigator Medium-sized Section 52:General internal medicine and related fields / Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / Neurology / Biological pharmacy / Neurochemistry/Neuropharmacology / Biological Sciences
Keywords	Principal Investigator 神経変性疾患 / 前頭側頭葉変性症 / 筋萎縮性側索硬化症 / アルツハイマー病 / FUS / アミロイドβ蛋白質 / CLAC / 前頭側頭葉型変性症 / オートファジー / TDP-43 … More / 神経科学 / 老人斑 / コラーゲン / アミロイドβペプチド / ARIA / 脳血管アミロイドアンギオパチー / オリゴマー / TDP=43 / 前頭側頭型認知症 / ALS / 神経変性 / アポリポプロテインE / アミロイドβタンパク質 / 脳神経疾患 / Aβ / CLAC-P / トランスジェニックマウス / βアミロイド / アルツハイマー … More Except Principal Investigator アルツハイマー病 / Aβ / アルツハイマー / 神経変性疾患 / アミロイドβ / 小胞輸送 / リピッドフリッパーゼ / βアミロイド / アミロイド / 液・液相分離 / 運動ニューロン疾患 / タウ蓄積症 / パーキンソン病 / 神経変性 / 細胞ストレス / 脂質輸送酵素 / βCTF / 小胞輸送障害 / 脳神経疾患 / tau / amyloid beta peptide / タウ / amyloid binding protein / Amyloid / γ-Secretase / Alzheimer's disease / 結合タンパク / γセクレターゼ / マイクロダイアリシス / 神経活動 / 光遺伝学 / シナプス / アミロイドβペプチド Less

アミロイドアンギオパチー蓄積機序解明と、ARIA回避型アルツハイマー病治療法開発Principal Investigator
- Principal Investigator
  
  橋本唯史
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 51:Brain sciences and related fields
- Research Institution
  National Center of Neurology and Psychiatry
Study for the mechanisms of oligomerization and toxicity of FUSPrincipal Investigator
- Principal Investigator
  
  Hashimoto Tadafumi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  National Center of Neurology and Psychiatry
Establishing quantitative and comprehensive methods for analyzing vesicular traffic impairment to identify the drug candidates for Alzheimer's disease
- Principal Investigator
  
  TAKASUGI NOBUMASA
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Okayama University
Stress dependent production and release of aggregated proteins in neurodegenerative disorders
- Principal Investigator
  
  Iwatsubo Takeshi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  The University of Tokyo
Elucidation of physiological and pathological roles of TDP-43 through autophagic machineryPrincipal Investigator
- Principal Investigator
  
  Hashimoto Tadafumi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  The University of Tokyo
Lipid flippase is the novel therapeutic target for the Alzheimer disease, which correlate with endocytic traffic impairment.
- Principal Investigator
  
  TAKASUGI NOBUMASA
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Okayama University
ALS病因タンパク質FUSの細胞間伝播及び神経細胞障害性発揮メカニズムの解明Principal Investigator
- Principal Investigator
  
  橋本唯史
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Elucidation of the molecular mechanisms of Abeta economy in the brain of Alzheimer's disease
- Principal Investigator
  
  Iwatsubo Takeshi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  The University of Tokyo
Elucidation of the pathomechanism of neurodegeneration induced by TDP-43Principal Investigator
- Principal Investigator
  
  Hashimoto Tadafumi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  The University of Tokyo
Study for the metabolism and neurotoxicity of amyloid beta peptide oligomersPrincipal Investigator
- Principal Investigator
  
  HASHIMOTO Tadafumi
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  The University of Tokyo
Elucidation of the molecular pathology of Alzheimer's disease focusing on the synapses toward therapies
- Principal Investigator
  
  IWATSUBO Takeshi
- Project Period (FY)
  2010 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
アルツハイマー病脳におけるアミロイド構成蛋白質CLACに関する研究Principal Investigator
- Principal Investigator
  
  橋本唯史
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  The University of Tokyo
アルツハイマー病新規アミロイド構成蛋白質CLACに関する病態生化学的研究Principal Investigator
- Principal Investigator
  
  橋本唯史
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  The University of Tokyo
Molecular and cell biological studies on the production, aggregation and clearance of Alzheimer amyloid β peptides.
- Principal Investigator
  
  IWATSYBO Takeshi
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  The University of Tokyo
アルツハイマー病脳老人斑アミロイドを構成する新規タンパク質CLACに関する研究Principal Investigator
- Principal Investigator
  
  橋本唯史
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  The University of Tokyo

[Journal Article] Ex vivo analysis platforms for monitoring amyloid precursor protein cleavage2023
- Author(s)
  Kamikubo Yuji、Jin Hao、Zhou Yiyao、Niisato Kazue、Hashimoto Yoshie、Takasugi Nobumasa、Sakurai Takashi
- Journal Title
  
  Frontiers in Molecular Neuroscience
  
  Volume: 15 Pages: 1068990-1068990
- DOI
  10.3389/fnmol.2022.1068990
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02815, KAKENHI-PROJECT-20K07014, KAKENHI-PROJECT-23K06170, KAKENHI-PROJECT-20K07765
[Journal Article] Lipid flippase dysfunction as a therapeutic target for endosomal anomalies in Alzheimer’s disease2022
- Author(s)
  Kaneshiro Nanaka、Komai Masato、Imaoka Ryosuke、Ikeda Atsuya、Kamikubo Yuji、Saito Takashi、Saido Takaomi C.、Tomita Taisuke、Hashimoto Tadafumi、Iwatsubo Takeshi、Sakurai Takashi、Uehara Takashi、Takasugi Nobumasa
- Journal Title
  
  iScience
  
  Volume: 25 Issue: 3 Pages: 103869-103869
- DOI
  10.1016/j.isci.2022.103869
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H01015, KAKENHI-PROJECT-21H02815, KAKENHI-PROJECT-19J22442, KAKENHI-PROJECT-20K07014, KAKENHI-PROJECT-20K07765, KAKENHI-PROJECT-21K07270
[Journal Article] Glymphatic system clears extracellular tau and protect from tau aggregation and neurodegeneration.2022
- Author(s)
  Ishida K, Yamada K, Nishiyama R, Hashimoto T, Nishida I, Abe Y, Yasui M, Iwatsubo T
- Journal Title
  
  Journal of Experimental Medicine
  
  Volume: 219 Issue: 3
- DOI
  10.1084/jem.20211275
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H00525, KAKENHI-PROJECT-19J21850, KAKENHI-PROJECT-21K07270
[Journal Article] Casein kinase 1δ/ε phosphorylates fused in sarcoma (FUS) and ameliorates FUS-mediated neurodegeneration2022
- Author(s)
  Kishino Yuya、Matsukawa Koji、Matsumoto Taisei、Miyazaki Ryota、Wakabayashi Tomoko、Nonaka Takashi、Kametani Fuyuki、Hasegawa Masato、Hashimoto Tadafumi、Iwatsubo Takeshi
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 298 Issue: 8 Pages: 102191-102191
- DOI
  10.1016/j.jbc.2022.102191
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07270, KAKENHI-PROJECT-22K07362, KAKENHI-PROJECT-20H00525, KAKENHI-PROJECT-22KJ0792
[Journal Article] ALS-linked cytoplasmic FUS assemblies are compositionally different from physiological stress granules and sequester hnRNPA3, a novel modifier of FUS toxicity2022
- Author(s)
  An Haiyan、Litscher Gioana、Watanabe Naruaki、Wei Wenbin、Hashimoto Tadafumi、Iwatsubo Takeshi、Buchman Vladimir L.、Shelkovnikova Tatyana A.
- Journal Title
  
  Neurobiology of Disease
  
  Volume: 162 Pages: 105585-105585
- DOI
  10.1016/j.nbd.2021.105585
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07270
[Journal Article] Long non-coding RNA NEAT1_1 ameliorates TDP-43 toxicity in in vivo models of TDP-43 proteinopathy2021
- Author(s)
  Matsukawa Koji、Kukharsky Michail S.、Park Sei-Kyoung、Park Sangeun、Watanabe Naruaki、Iwatsubo Takeshi、Hashimoto Tadafumi、Liebman Susan W.、Shelkovnikova Tatyana A.
- Journal Title
  
  RNA Biology
  
  Volume: 1 Issue: 11 Pages: 1-9
- DOI
  10.1080/15476286.2020.1860580
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19J14374, KAKENHI-PROJECT-18K07364, KAKENHI-PROJECT-21K07270
[Journal Article] Behavioral and electrophysiological evidence for a neuroprotective role of aquaporin-4 in the 5xFAD transgenic mice model2020
- Author(s)
  Abe Y, Ikegawa N, Yoshida K, Muramatsu K, Hattori S, Kawai K, Murakami M, Tanaka T, Goda W, Goto Zm, Yamamoto T, Hashimoto T, Yamada K, Shibata T, Misawa H, Mimura M, Tanaka KF, Miyakawa T, Iwatsubo T, Hata J, Niikura T, Yasui M
- Journal Title
  
  Acta Neuropathologica Communications
  
  Volume: 8 Issue: 1 Pages: 67-67
- DOI
  10.1186/s40478-020-00936-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07364, KAKENHI-PROJECT-19K07128, KAKENHI-PUBLICLY-19H05027, KAKENHI-PLANNED-20H05896, KAKENHI-PROJECT-18H02606, KAKENHI-PROJECT-16H06276
[Journal Article] Collagenous Alzheimer amyloid plaque component impacts on the compaction of amyloid-β plaques2020
- Author(s)
  Hashimoto Tadafumi、Fujii Daisuke、Naka Yasushi、Kashiwagi-Hakozaki Mayu、Matsuo Yuko、Matsuura Yusuke、Wakabayashi Tomoko、Iwatsubo Takeshi
- Journal Title
  
  Acta Neuropathologica Communications
  
  Volume: 8 Issue: 1 Pages: 212-212
- DOI
  10.1186/s40478-020-01075-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07364, KAKENHI-PROJECT-20H00525, KAKENHI-PROJECT-19J12600
[Journal Article] Differential effects of diet- and genetically-induced brain insulin resistance on amyloid pathology in a mouse model of Alzheimer’s disease2019
- Author(s)
  Tomoko Wakabayashi, Kazuki Yamaguchi, Kentaro Matsui, Toshiharu Sano, Tetsuya Kubota, Tadafumi Hashimoto, Ayako Mano, Kaoru Yamada, Yuko Matsuo, Naoto Kubota, Takashi Kadowaki, Takeshi Iwatsubo
- Journal Title
  
  Molecular Neurodegeneration
  
  Volume: 14 Issue: 1 Pages: 15-15
- DOI
  10.1186/s13024-019-0315-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07364, KAKENHI-PROJECT-19K08991, KAKENHI-PROJECT-19H01052, KAKENHI-PROJECT-26000012, KAKENHI-PROJECT-17H04193, KAKENHI-PROJECT-18H02860
[Journal Article] Characterization of the unique in vitro effects of unsaturated fatty acids on the formation of amyloid beta fibrils2019
- Author(s)
  Miki Eto, Tadafumi Hashimoto, Takao Shimizu, Takeshi Iwatsubo
- Journal Title
  
  PLoS ONE
  
  Volume: 14 Issue: 7 Pages: e0219465-e0219465
- DOI
  10.1371/journal.pone.0219465
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07364, KAKENHI-PROJECT-17H04193
[Journal Article] Roles of collagen XXV and its putative receptors PTP s/d in intramuscular motor innervation and congenital cranial dysinnervation disorder2019
- Author(s)
  Haruka Munezane, Hiroaki Oizumi, Tomoko Wakabayashi, Shu Nishio, Tomoko Hirasawa, Takashi Sato, Akihiro Harada, Tomoyuki Yoshida, Takahiro Eguchi, Yuji Yamanashi, Tadafumi Hashimoto, Takeshi Iwatsubo
- Journal Title
  
  Cell Reports
  
  Volume: 29 Issue: 13 Pages: 4362-4376
- DOI
  10.1016/j.celrep.2019.11.112
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07364, KAKENHI-PROJECT-19K06435, KAKENHI-ORGANIZER-17H06413, KAKENHI-PUBLICLY-19H04744, KAKENHI-PROJECT-17K07091, KAKENHI-PROJECT-17H01532, KAKENHI-PROJECT-17H04193
[Journal Article] Calcium-responsive transactivator (CREST) toxicity is rescued by loss of PBP1/ATXN2 function in a novel yeast proteinopathy model and in transgenic flies2019
- Author(s)
  Sangeun Park, Sei-Kyoung Park, Naruaki Watanabe, Tadafumi Hashimoto, Takeshi Iwatsubo, Tatyana A. Shelkovnikova, Susan W Liebman
- Journal Title
  
  PLoS Genetics
  
  Volume: 15 Issue: 8 Pages: 1-26
- DOI
  10.1371/journal.pgen.1008308
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07364, KAKENHI-PROJECT-19J14374
[Journal Article] Chronic cerebral hypoperfusion shifts the equilibrium of amyloid β oligomers to aggregation-prone species with higher molecular weight2019
- Author(s)
  Bannai Taro、Mano Tatsuo、Chen Xigui、Ohtomo Gaku、Ohtomo Ryo、Tsuchida Takeyuki、Koshi-Mano Kagari、Hashimoto Tadafumi、Okazawa Hitoshi、Iwatsubo Takeshi、Tsuji Shoji、Toda Tatsushi、Iwata Atsushi
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 2827-2827
- DOI
  10.1038/s41598-019-39494-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07364, KAKENHI-PUBLICLY-17H05687, KAKENHI-PROJECT-16H05319, KAKENHI-PROJECT-17H04193, KAKENHI-PROJECT-17K16113, KAKENHI-PROJECT-16H02655
[Journal Article] Self-assembly of FUS through its low-complexity domain contributes to neurodegeneration.2018
- Author(s)
  Taisei Matsumoto, Koji Matsukawa, Naruaki Watanabe, Yuya Kishino, Hayato Kunugi, Ryoko Ihara, Tomoko Wakabayashi, Tadafumi Hashimoto, Takeshi Iwatsubo
- Journal Title
  
  Human Molecular Genetics
  
  Volume: 印刷中 Issue: 8 Pages: 1353-1365
- DOI
  10.1093/hmg/ddy046
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-17H05687, KAKENHI-PROJECT-15K08297, KAKENHI-PROJECT-18K07364
[Journal Article] Patterns and severity of vascular amyloid in Alzheimer’s disease associated with duplications and missense mutations in APP gene, Down syndrome and sporadic Alzheimer’s disease2018
- Author(s)
  Mann David M. A.、Davidson Yvonne S.、Robinson Andrew C.、Allen Nancy、Hashimoto Tadafumi、Richardson Anna、Jones Matthew、Snowden Julie S.、Pendleton Neil、Potier Marie-Claude、Laquerri?re Annie、Prasher Vee、Iwatsubo Takeshi、Strydom Andre
- Journal Title
  
  Acta Neuropathologica
  
  Volume: 136 Issue: 4 Pages: 569-587
- DOI
  10.1007/s00401-018-1866-3
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07364, KAKENHI-PUBLICLY-17H05687, KAKENHI-PROJECT-17H04193
[Journal Article] TMEM30A is a candidate interacting partner for the β-carboxyl-terminal fragment of amyloid-β precursor protein in endosomes2018
- Author(s)
  Takasugi Nobumasa、Araya Runa、Kamikubo Yuji、Kaneshiro Nanaka、Imaoka Ryosuke、Jin Hao、Kashiyama Taku、Hashimoto Yoshie、Kurosawa Masaru、Uehara Takashi、Nukina Nobuyuki、Sakurai Takashi
- Journal Title
  
  PLOS ONE
  
  Volume: 13 Issue: 8 Pages: 0200988-0200988
- DOI
  10.1371/journal.pone.0200988
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08272, KAKENHI-PROJECT-17K09040, KAKENHI-PROJECT-17H01564, KAKENHI-PROJECT-16H04667, KAKENHI-PROJECT-18H00446
[Journal Article] Soluble oligomeric amyloid-beta induces calcium dyshomeostasis that precedes synapse loss in the living mouse brain.2017
- Author(s)
  Michal Arbel-Ornath, Eloise Hudry, Josiah R Bovine, Tadafumi Hashimoto, Shuko Takeda, Kishore V Kuchbhotla, Steven Hou, Carli R Lattarulo, Arianna M Belcher, Naomi Shakerdge, Pariss B Trujillo, Alona Muzikansky, Rebecca A Betensky, Bradley T Hyman, and Brian J Bacskai
- Journal Title
  
  Molecular Neurodegeneration
  
  Volume: 12 Issue: 1 Pages: 27-27
- DOI
  10.1186/s13024-017-0169-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08297, KAKENHI-PUBLICLY-17H05687
[Journal Article] Neuron-specific methylome analysis reveals epigenetic regulation and tau-related dysfunction of BRCA1 in Alzheimer’s disease2017
- Author(s)
  Mano Tatsuo、Nagata Kenichi、Nonaka Takashi、Tarutani Airi、Imamura Tomohiro、Hashimoto Tadafumi、Bannai Taro、Koshi-Mano Kagari、Tsuchida Takeyuki、Ohtomo Ryo、Takahashi-Fujigasaki Junko、Yamashita Satoshi、Ohyagi Yasumasa、Yamasaki Ryo、Tsuji Shoji、Tamaoka Akira、et al.
- Journal Title
  
  Proc Natl Acad Sci U.S.A.
  
  Volume: 114 Issue: 45
- DOI
  10.1073/pnas.1707151114
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09664, KAKENHI-PROJECT-17K16113, KAKENHI-PUBLICLY-17H05687, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-15H02356, KAKENHI-PROJECT-16H05319, KAKENHI-PROJECT-15K08297, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-16H06297
[Journal Article] Familial Amyotrophic Lateral Sclerosis-linked Mutations in Profilin 1 Exacerbate TDP-43-induced Degeneration in the Retina of Drosophila melanogaster through an Increase in the Cytoplasmic Localization of TDP-43.2016
- Author(s)
  Matsukawa K, Hashimoto T, Matsumoto T, Ihara R, Chihara T, Miura M, Wakabayashi T, Iwatsubo T.
- Journal Title
  
  J Biol Chem
  
  Volume: 291 Issue: 45 Pages: 23464-23476
- DOI
  10.1074/jbc.m116.729152
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H04375, KAKENHI-PROJECT-14J06189, KAKENHI-PROJECT-15K08297
[Journal Article] Calcium-responsive transactivator (CREST) protein shares a set of structural and functional traits with other proteins associated with amyotrophic lateral sclerosis2015
- Author(s)
  Michail S. Kukharsky, Annamaria Quintiero, Taisei Matsumoto, Koji Matsukawa, Haiyan An, Tadafumi Hashimoto, Takeshi Iwatsubo, Vladimir L. Buchman, Tatyana A. Shelkovnikova
- Journal Title
  
  Molecular Neurodegeneration
  
  Volume: 10 Issue: 1
- DOI
  10.1186/s13024-015-0014-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08297, KAKENHI-PROJECT-14J06189
[Journal Article] Chronic optogenetic activation augments Aβ pathology in a mouse model of Alzheimer disease2015
- Author(s)
  Kaoru Yamamoto, Zen-ichi Tanei, Tadafumi Hashimoto, Tomoko Wakabayashi, Hiroyuki Okuno, Yasushi Naka, Ofer Yizhar, Lief E. Fenno, Masashi Fukayama, Haruhiko Bito, John R. Cirrito, David M. Holtzman, Karl Deisseroth, Takeshi Iwatsubo
- Journal Title
  
  Cell reports
  
  Volume: 11 Issue: 6 Pages: 859-865
- DOI
  10.1016/j.celrep.2015.04.017
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-22110003, KAKENHI-PROJECT-221S0003, KAKENHI-PROJECT-15K08297, KAKENHI-PROJECT-15H02358
[Journal Article] Role of apolipoprotein E in β-amyloidgenesis: isoform-specific effects on protofibril to fibril conversion of Aβ in vitro and brain Aβ deposition in vivo.2015
- Author(s)
  Yukiko Hori, Tadafumi Hashimoto, Hidetoshi Nomoto, Bradley T Hyman, Takeshi Iwatsubo
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 290 Issue: 24 Pages: 15163-15174
- DOI
  10.1074/jbc.m114.622209
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08297, KAKENHI-PROJECT-26893042
[Journal Article] RNA aptamer probes as optical imaging agents for the detection of amyloid plaques2014
- Author(s)
  Farrar CT, William CM, Hudry E, Hashimoto T, Hyman BT
- Journal Title
  
  PLoS One
  
  Volume: 9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24800015
[Journal Article] CLAC-P/collagen type XXV is required for the intramuscular innervation of motoneurons during neuromuscular development.2014
- Author(s)
  Tanaka T, Wakabayashi T, Oizumi H, Nishio S, Sato T, Harada A, Fujii D, Matsuo Y, Hashimoto T, Iwatsubo T.
- Journal Title
  
  J Neurosci.
  
  Volume: 34 Issue: 4 Pages: 1370-1379
- DOI
  10.1523/jneurosci.2440-13.2014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591347, KAKENHI-PROJECT-24390046, KAKENHI-PROJECT-24659084, KAKENHI-PROJECT-24700373, KAKENHI-PROJECT-24800015, KAKENHI-PUBLICLY-25113517
[Journal Article] CLAC-P/collagen type XXV is required for the intramuscular innervation of motoneurns during neuromuscular development2014
- Author(s)
  Tomohiro Tanaka, Tomoko Wakabayashi, Hiroaki Oizumi, Shu Nishio, Takashi Sato, Akihiro Harada, Daisuke Fujii, Yuko Matsuo, Tadafumi Hashimoto, and Takeshi Iwatsubo
- Journal Title
  
  J. Neurosci.
  
  Volume: 34(4) Pages: 1370-1379
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24800015
[Journal Article] RNA aptamer probes as optical imaging agenets for the detection of amyloid plaques2014
- Author(s)
  Christian T Farrar, Christopher M William, Eloise Hudry, Tadafumi Hashimoto, and Hyman BT
- Journal Title
  
  PLoS ONE
  
  Volume: 9(2)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24800015
[Journal Article] Human ApoE isoforms delivered via gene transfer differentially modulate Alzheimer's disease by affecting amyloid deposition, clearance, and neurotoxicity2013
- Author(s)
  Eloise Hudry, Jonathan Dashkoff, Allyson Lee, Shuko Takeda, Robert M. Koffie, Tadafumi Hashimoto, Maria Scheel, Tara Spires-Jones, Michal Arbel-Ornath, Rebecca Betensky, Beverly L Davidson, and Bradley T Hyman
- Journal Title
  
  Sci. Trans. Med.
  
  Volume: 5(212) Issue: 212
- DOI
  10.1126/scitranslmed.3007000
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24800015
[Journal Article] RNA binding mediates neurotoxicity in the transgenic Drosophila model of TDP-43 proteinopathy.2013
- Author(s)
  Ihara R, Matsukawa K, Nagata Y, Kunugi H, Tsuji S, Chihara T, Kuranaga E, Miura M, Wakabayashi T, Hashimoto T, Iwatsubo T.
- Journal Title
  
  Hum Mol Genet.
  
  Volume: 22(22) Issue: 22 Pages: 4474-4484
- DOI
  10.1093/hmg/ddt296
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21117006, KAKENHI-PROJECT-23687032, KAKENHI-PROJECT-24687027, KAKENHI-PROJECT-24800015, KAKENHI-PROJECT-25650074
[Journal Article] Microfluidic chemotaxis platform for differentiating the roles of soluble and bound amyloid-beta on microglia accumulation2013
- Author(s)
  Hansang Cho, Tadafumi Hashimoto, Elisabeth Wong, Yukiko Hori, Levi B Wood, Lingzhi Zhao, Kevin M Daigis, Bradley T Hyman, and Daniel Irimia
- Journal Title
  
  Sci. Rep.
  
  Volume: 3 Issue: 1 Pages: 1823-1823
- DOI
  10.1038/srep01823
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24800015
[Journal Article] Brain interstitial oligomeric amyloid beta increases with age and is resistant to clearance from brain in a mouse model of Alzheimer's disease2013
- Author(s)
  Shuko Takeda, Tadafumi Hashimoto, Alberto Serrano-Pozo, Allyson D Roe, Tara L Spires-Jones, and Bradley T Hyman
- Journal Title
  
  FASEB. J
  
  Volume: 27(8) Issue: 8 Pages: 3239-3248
- DOI
  10.1096/fj.13-229666
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24800015
[Journal Article] Neuronal activity and secreted amyloid beta lead to altered amyloid beta precursor protein and presenilin 1 interactions2012
- Author(s)
  Xuejing Li, Kengo Uemura, Tadafumi Hashimoto, Navine Nasser-Ghodsi, Muriel Arimon, Christina M Lill, Isabella Palazzolo, Dimitri Krainc, Bradley T Hyman, and Oksana Berezovska
- Journal Title
  
  Neurobiol. Dis.
  
  Volume: 50 Pages: 127-134
- DOI
  10.1016/j.nbd.2012.10.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24800015
[Journal Article] Apolipoprotein E, especially apolipoprotein E4, increases the oligomerization of amyloid β peptide2012
- Author(s)
  Tadafumi Hashimoto
- Journal Title
  
  Journal of Neuroscience
  
  Volume: 32 Pages: 15181-15192
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24800015
[Journal Article] Apolipoprotein E, especially apolipoprotein E4, increases the oligomerization of amyloid β peptide.2012
- Author(s)
  T.Hashimoto, A.Serrano-Pozo, Y.Hori, et al
- Journal Title
  
  The Journal of Neuroscience
  
  Volume: 32 Issue: 43 Pages: 15181-15192
- DOI
  10.1523/jneurosci.1542-12.2012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J09836, KAKENHI-PROJECT-24800015
[Journal Article] The synaptic accumulation of hyperphosphorylated tau oligomers in Alzheimer disease is associated with dysfunction of the ubiquitin-proteasome system2012
- Author(s)
  Hwan-Ching Tai, Alberto Serrano-Pozo, Tadafumi Hashimoto, Matthew P Frosch, Tara L Spires-Jones, and Bradley T Hyman
- Journal Title
  
  Am. J. Pathol.
  
  Volume: 181 Issue: 4 Pages: 1426-1435
- DOI
  10.1016/j.ajpath.2012.06.033
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24800015
[Journal Article] The Tottori (D7N) and English (H6R) familial Alzheimer's disease mutations accelerate All fibril formation without increasing protofibril formation2007
- Author(s)
  Hori Y, Hashimoto T, Wakutani Y, Urakami K, Nakashima K, Condron MM, Tsubuki S, Saido TC, Teplow DB, Iwatsubo T
- Journal Title
  
  J Biol Chem 282
  
  Pages: 4916-4923
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17200025
[Journal Article] Major involvement of low-density lipoprotein receptor-related protein 1 in the clearance of plasma free amyloid β-peptide by the liver2006
- Author(s)
  Tamaki C, Ohtsuki S, Iwatsubo T, Hashimoto T, Yamada K, Yabuki C, Terasaki T
- Journal Title
  
  Pharmaceut Res 23
  
  Pages: 1407-1416
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17200025
[Journal Article] Patholoeical effects of CLAC in the brains of APP/CLAC-P double transgenic mice2006
- Author(s)
  Hashimoto T
- Journal Title
  
  Alzheimer's Dementia 2
- Data Source
  KAKENHI-PROJECT-17790050
[Journal Article] CLAC binds to amyloid β peptides through the positively-charged amino acid cluster within the collagenous domain 1 and inhibits formation of amyloid fibrils2005
- Author(s)
  Osada Y, Hashimoto T, Nishimura A, Matsuo Y Wakabayashi T, Iwatsubo T.
- Journal Title
  
  J Biol Chem 280
  
  Pages: 8596-8605
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17200025
[Presentation] Casein kinase 1delta/epsilonがFUSの神経毒性に与える影響に関する検討2022
- Author(s)
  岸野祐也、松川浩二、松本大成、宮崎良太、若林朋子、野中隆、亀谷富由樹、長谷川成人、橋本唯史、岩坪威
- Organizer
  第41回日本認知症学会
- Data Source
  KAKENHI-PROJECT-21K07270
[Presentation] Detection of seed-competent, high-molecular-weight Abeta oligomers in the cerebrovasculature in Alzheimer’s disease2022
- Author(s)
  Tadafumi Hashimoto, Hirokazu Uchigami, Mayu Kashiwagi-Hakozaki, Tomoyasu Matsubara, Shigeo Murayama, Yuko Saito, Tatsushi Toda, Takeshi Iwatsubo
- Organizer
  Neuroscience2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07270
[Presentation] Aquaporin4 がタウ蓄積と神経変性に果たす役割2021
- Author(s)
  山田　薫、石田　和久、橋本　唯史、阿部　陽一郎、安井　正人、岩坪　威
- Organizer
  第40回日本認知症学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-20H00525
[Presentation] Isoform- and dose-dependent effects of apolipoprotein E in the deposition of Abeta in the brain of APP transgenic mice.2021
- Author(s)
  Tadafumi Hashimoto, Asuka Kokawa, Maiko Tanaka, Yutaro Ohno, Mayu Kashiwagi-Hakozaki, Takeshi Iwatsubo
- Organizer
  Neuroscience2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07270
[Presentation] The analysis for APP-βCTF mediated traffic impairment in AD2021
- Author(s)
  Nanaka Kaneshiro, Tadafumi Hashimoto, Takashi Sakurai, Takashi Uehara, Nobumasa Takasugi
- Organizer
  第40回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-20K07014
[Presentation] FUSの多量体化と神経毒性・伝播2021
- Author(s)
  橋本唯史
- Organizer
  第40回日本認知症学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-21K07270
[Presentation] Aquaporin-4 deficiency exacerbates tau accumulation and neurodegeneration in a mouse model of tauopathies.2020
- Author(s)
  Yamada K, Ishida K, Hashimoto T, Abe Y, Yasui M, Iwatsubo T
- Organizer
  第 43回日本神経科学大会
- Invited
- Data Source
  KAKENHI-PROJECT-20H00525
[Presentation] The analysis for APP-βCTF mediated traffic impairment in AD2020
- Author(s)
  Nanaka Kaneshiro, Tadafumi Hashimoto, Takashi Sakurai, Takashi Uehara, Nobumasa Takasugi
- Organizer
  第39回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-20K07014
[Presentation] 脳内でβ―アミロイド蓄積を誘発する可溶な高分子量Aβオリゴマーの同定2019
- Author(s)
  箱崎眞結、仲泰史、深山正久、牛久哲男、橋本唯史、岩坪威
- Organizer
  第42回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-18K07364
[Presentation] Role of arginine methylation in the intercellular transmission of FUS2019
- Author(s)
  Naruaki Watanabe, Koji Matsukawa, Mark Suarez-Calvet, Dorothee Dormann, Tadafumi Hashimoto, Takeshi Iwatsubo
- Organizer
  Neuroscience2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07364
[Presentation] Soluble high-molecular weight oligomers of amyloid-beta peptide derived from the brains of APP transgenic mice induce cerebral amyloid-beta deposits2019
- Author(s)
  Tadafumi Hashimoto, Yasushi Naka, Kashiwagi-Hakozaki Mayu, Tomoya Tajiri, Takeshi Iwatsubo
- Organizer
  Neuroscience2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07364
[Presentation] ヒト型とマウス型apolipoprotein EがAβの凝集及び蓄積に与える影響の相違2019
- Author(s)
  粉川明日香、大野裕太郎、橋本唯史、岩坪威
- Organizer
  第42回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-18K07364
[Presentation] Soluble high-molecular weight oligomers of amyloid-beta peptide derived from the brains of APP transgenic mice induce cerebral amyloid-beta deposits2019
- Author(s)
  Tadafumi Hashimoto, Yasushi Naka, Kashiwagi-Hakozaki Mayu, Tomoya Tajiri, Takeshi Iwatsubo
- Organizer
  Neuroscience2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04193
[Presentation] Characterization of the seed Abeta oligomers in the brains of APP transgenic mice2018
- Author(s)
  Mayu Hakozaki-Kashiwagi, Yasushi Naka, Tomohiko Tajiri, Masashi Fukayama, Tadafumi Hashimoto, Takeshi Iwatsubo
- Organizer
  19th International Congress of Neuropathology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07364
[Presentation] アミロイド斑蓄積のseedとして働く可溶性Abetaオリゴマーの同定2018
- Author(s)
  箱崎眞結、仲泰史、田尻智也、深山正久、橋本唯史、岩坪威
- Organizer
  第37回日本認知症学会
- Data Source
  KAKENHI-PROJECT-18K07364
[Presentation] FUSの細胞間伝播機序に関する研究2018
- Author(s)
  渡邊成晃、松川浩二、橋本唯史、岩坪威
- Organizer
  第37回日本認知症学会
- Data Source
  KAKENHI-PUBLICLY-17H05687
[Presentation] FUSの細胞間伝播機序に関する研究2018
- Author(s)
  渡邊成晃、松川浩二、橋本唯史、岩坪威
- Organizer
  第37回日本認知症学会
- Data Source
  KAKENHI-PROJECT-18K07364
[Presentation] アミロイド斑蓄積のseedとして働く可溶性Abetaオリゴマーの同定2018
- Author(s)
  箱崎眞結、仲泰史、田尻智也、深山正久、橋本唯史、岩坪威
- Organizer
  第37回日本認知症学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04193
[Presentation] FUS induces neurodegeneration through its low-complexity domain in the drosophila retina.2018
- Author(s)
  Tadafumi Hashimoto, Taisei Matsumoto, Yuya Kishino, Koji Matsukawa, Naruaki Watanabe, Tomoko Wakabayashi, Takeshi Iwatsubo
- Organizer
  Neuroscience2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07364
[Presentation] FUS induces neurodegeneration through its low-complexity domain in the drosophila retina.2018
- Author(s)
  Tadafumi Hashimoto, Taisei Matsumoto, Yuya Kishino, Koji Matsukawa, Naruaki Watanabe, Tomoko Wakabayashi, Takeshi Iwatsubo
- Organizer
  Neuroscience2018
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05687
[Presentation] ヒト型とマウス型apolipoprotein EがAbeta脳内dynamicsに与える影響の相違2018
- Author(s)
  粉川明日香、大野裕太郎、橋本唯史、岩坪威
- Organizer
  第37回日本認知症学会
- Data Source
  KAKENHI-PROJECT-18K07364
[Presentation] Characterization of the seed Abeta oligomers in the brains of APP transgenic mice2018
- Author(s)
  Mayu Hakozaki-Kashiwagi, Yasushi Naka, Tomohiko Tajiri, Masashi Fukayama, Tadafumi Hashimoto, Takeshi Iwatsubo
- Organizer
  19th International Congress of Neuropathology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04193
[Presentation] ヒト型とマウス型apolipoprotein EがAbeta脳内dynamicsに与える影響の相違2018
- Author(s)
  粉川明日香、大野裕太郎、橋本唯史、岩坪威
- Organizer
  第37回日本認知症学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04193
[Presentation] Casein kinase 1 delta/ipsilonがFUSの神経毒性に与える影響に関する検討2017
- Author(s)
  岸野祐也、松川浩二、野中隆、松本大成、長谷川成人、橋本唯史、岩坪威
- Organizer
  日本認知症学会
- Data Source
  KAKENHI-PUBLICLY-17H05687
[Presentation] Characterization of the high molecular weight Abeta oligomers derived from the brains of APP transgenic mice2017
- Author(s)
  Tadafumi Hashimoto, Yasushi Naka, Tomoya Tajiri, Mayu Hakozaki-Kashiwagi, Takeshi Iwatsubo
- Organizer
  Neuroscience2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08297
[Presentation] Casein kinase 1 delta/ipsilon がFUSの神経毒性に与える影響に関する検討2017
- Author(s)
  岸野祐也、松川浩二、野中隆、松本大成、長谷川成人、橋本唯史、岩坪威
- Organizer
  第36回日本認知症学会
- Data Source
  KAKENHI-PROJECT-15K08297
[Presentation] Characterization of the high molecular weight Ab oligomers derived from the brains of APP transgenic mice2017
- Author(s)
  Tadafumi Hashimoto, Yasushi Naka, Tomoya Tajiri, Mayu Hakozaki-Kashiwagi, Takeshi Iwatsubo
- Organizer
  Neuroscience2017
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05687
[Presentation] Characterization of the high molecular weight Abeta oligomers derived from the brains of APP transgenic mice2017
- Author(s)
  Tadafumi Hashimoto, Yasushi Naka, Tomoya Tajiri, Mayu Hakozaki-Kashiwagi, Takeshi Iwatsubo
- Organizer
  Neuroscience2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04193
[Presentation] Differential effects of human and mouse apolipoprotein E on the metabolism and aggregation of amyloid-b peptides2017
- Author(s)
  Asuka Kokawa, Yutaro Ohno, Tadafumi Hashimoto, Takeshi Iwatsubo
- Organizer
  Neuroscience2017
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05687
[Presentation] Differential effects of human and mouse apolipoprotein E on the metabolism and aggregation of amyloid-beta peptides2017
- Author(s)
  Asuka Kokawa, Yutaro Ohno, Tadafumi Hashimoto, Takeshi Iwatsubo
- Organizer
  Neuroscience2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08297
[Presentation] Differential effects of human and mouse apolipoprotein E on the metabolism and aggregation of amyloid-beta peptides2017
- Author(s)
  Asuka Kokawa, Yutaro Ohno, Tadafumi Hashimoto, Takeshi Iwatsubo
- Organizer
  Neuroscience2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04193
[Presentation] The relationship between insulin resistance and amyloid pathology in diabetic AD model mice2017
- Author(s)
  K Matsui, K Yamaguchi, A Mano, T Sano, T Hashimoto, T Kubota, T Kadowaki, T Wakabayashi, T Iwatsubo
- Organizer
  Neuroscience2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08297
[Presentation] ヒトapoEがAβの脳内dynamicsに与える影響の解明2016
- Author(s)
  粉川明日香、大野裕太郎、橋本唯史、岩坪威
- Organizer
  第35回日本認知症学会
- Place of Presentation
  東京国際フォーラム（東京都千代田区）
- Year and Date
  2016-12-01
- Data Source
  KAKENHI-PROJECT-15K08297
[Presentation] TDP-43はAtg1/ULK1のプロセシング異常を介して神経変性を引き起こす2016
- Author(s)
  松川浩二、岸野祐也、若林朋子、橋本唯史、岩坪威
- Organizer
  第35回日本認知症学会
- Place of Presentation
  東京国際フォーラム（東京都千代田区）
- Year and Date
  2016-12-01
- Data Source
  KAKENHI-PROJECT-15K08297
[Presentation] Roles of Ab plaques on the dynamics of soluble Ab in the brains of APP transgenic mice.2016
- Author(s)
  Yasushi Naka, Tomoko Wanabayashi, Tadafumi Hashimoto, Takeshi Iwatsubo
- Organizer
  Neuroscience 2016
- Place of Presentation
  San Diego, USA
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08297
[Presentation] Novel cellular and in vivo models for intercellular transmission of FUS2016
- Author(s)
  Tadafumi Hashimoto, Taisei Matsumoto, Koji Matsukawa, Naruaki Watanabe, Tomoko Wakabayashi, Takeshi Iwatsubo
- Organizer
  Gordon Research Conferences. Neurobiology of brain disorders
- Place of Presentation
  Girona, Spain
- Year and Date
  2016-08-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08297
[Presentation] Development of a novel cell-based model for oligomerization and intercellular transmission of FUS2016
- Author(s)
  Tadafumi Hashimoto, Taisei Matsumoto, Koji Matsukawa, Naruaki Watanabe, Tomoko Wakabayashi, Takeshi Iwatsubo
- Organizer
  Neuroscience 2016
- Place of Presentation
  San Diego, USA
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08297
[Presentation] Self-assembly of FUS is required for the degeneration of retinal photoreceptor neurons in transgenic Drosophila melanogaster overexpressing human FUS2015
- Author(s)
  Tadafumi Hashimoto, Taisei Matsumoto, Hayato Kunugi, Koji Matsukawa, Tomoko Wakabayashi, Takeshi Iwatsubo
- Organizer
  10th Brain Research Conference
- Place of Presentation
  Chicago, USA
- Year and Date
  2015-10-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08297
[Presentation] CLAC alters the morphology and dynamics of amyloid-β peptides in the brain2015
- Author(s)
  Tadafumi Hashimoto, Yasushi Naka, Daisuke Fujii, Mayu Kashiwagi, Tomoko Wakabayashi, Takeshi Iwatsubo
- Organizer
  Neuroscience 2015
- Place of Presentation
  Chicago, USA
- Year and Date
  2015-10-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08297
[Presentation] Two distinct pathways leading to degeneration in transgenic Drosophila melanogaster overexpressing human FUS2013
- Author(s)
  Tadafumi Hashimoto, Hayato Kunugi, Koji Matsukawa, hirokazu Uchigami, Ryoko Ihara, Takahiro Chihara, Masayuki Miura, Tomoko Wakabayashi, and Takeshi Iwatsubo
- Organizer
  Alzheimer's Association International Conference
- Place of Presentation
  Boston, USA.
- Year and Date
  2013-07-14
- Data Source
  KAKENHI-PROJECT-24800015
[Presentation] オプとジェネティックスを用いた神経活動依存的なAβ分泌・蓄積の検討2013
- Author(s)
  山本薫、奥野浩行、Cirrito JR, Holtzman DM, Yizhar O, Fenno LF, Deisseroth K, 尾藤晴彦、若林朋子、橋本唯史、岩坪威
- Organizer
  第５４回神経病理学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24800015
[Presentation] Apolipoprotein E, especially apolipoprotein E4, increases the oligomerization of amyloid beta peptide. Gordon Research Conferences, Neurobiology of brain disorders2012
- Author(s)
  Tadafumi Hashimoto, Alberto Serrano-Pozo, Yukiko Hori, Hwan-Ching Tai, Kenneth W Adams, Shuko Takeda, Daniel Joyner, Diana H Thyssen, Brian J Bacskai, Matthew P Frosch, Tara L Spires-Jones, Mary Beth Finn, David M Holtzman, and Bradley T Hyman
- Organizer
  Neurobiology of brain disorders
- Place of Presentation
  Easton, USA.
- Data Source
  KAKENHI-PROJECT-24800015
[Presentation] Remodeling of the morphology of β-amyloid plaques by CLAC in the brains of transgenic mice2012
- Author(s)
  Tadafumi Hashimoto
- Organizer
  Society for Neuroscience
- Place of Presentation
  New Orleans, USA
- Data Source
  KAKENHI-PROJECT-24800015
[Presentation] Remodeling of the morphology of beta-amyloid plaques by CLAC in the brains of transgenic mice2012
- Author(s)
  Tadafumi Hashimoto, Daisuke Fujii, Mayu Kashiwagi, Yuko Matsuo, Yusuke Matsura, Tomoko Sakakura, Hisatomo Kowa, David Westaway, Tomoko Wakabayashi, and Takeshi Iwatsubo
- Organizer
  Society for Neuroscience
- Place of Presentation
  New Oreleans, USA.
- Year and Date
  2012-10-15
- Data Source
  KAKENHI-PROJECT-24800015
[Presentation] オプとジェネティックスを用いた神経活動依存的なAβ分泌・蓄積の検討2012
- Author(s)
  山本薫、奥野浩行、尾藤晴彦、若林朋子、橋本唯史、岩坪威
- Organizer
  第３１回　日本認知症学会
- Place of Presentation
  筑波市
- Invited
- Data Source
  KAKENHI-PLANNED-22110003
[Presentation] Isoform-specific effects of apolipoprotein E on the stability of Aβ protofibrils2007
- Author(s)
  Hashimoto T
- Organizer
  37th society for neuroscience
- Place of Presentation
  San Diego
- Year and Date
  2007-11-04
- Data Source
  KAKENHI-PROJECT-19790050
[Presentation] Amyloid β aggregation: role of interactor proteins2007
- Author(s)
  Hashimoto T
- Organizer
  IBRO 2007
- Place of Presentation
  Melbourne
- Year and Date
  2007-07-15
- Data Source
  KAKENHI-PROJECT-19790050
[Presentation] Two distinct pathways leading to degeneration in transgenic Drosophila melanogaster overexpressing human FUS
- Author(s)
  Hashimoto T, Kunugi H, Matsukawa K, Uchigami H, Ihara R, Chihara T, Miura M, Wakabayashi T, Iwatsubo T
- Organizer
  Alzheimer's Association International Conference
- Place of Presentation
  Boston, USA
- Data Source
  KAKENHI-PROJECT-24800015

1. IWATSUBO Takeshi (50223409)

# of Collaborated Projects: 4 results

# of Collaborated Products: 14 results
2. WAKABAYASHI Tomoko (20530330)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
3. TAKASUGI NOBUMASA (60436590)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
4. 山田薫 (00735152)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
5. ITO Genta (10431892)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. 桑原知樹 (10533903)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 桜井正樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 富田泰輔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 倉永英里奈

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 佐藤隆史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 千原崇裕

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 玉岡晃

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HASHIMOTO TADAFUMI 橋本 唯史

HASHIMOTO Tadafumi 橋本 唯史

Research Projects

Research Products

Co-Researchers

アミロイドアンギオパチー蓄積機序解明と、ARIA回避型アルツハイマー病治療法開発Principal Investigator

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Study for the mechanisms of oligomerization and toxicity of FUSPrincipal Investigator

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Establishing quantitative and comprehensive methods for analyzing vesicular traffic impairment to identify the drug candidates for Alzheimer's disease

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Stress dependent production and release of aggregated proteins in neurodegenerative disorders

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Elucidation of physiological and pathological roles of TDP-43 through autophagic machineryPrincipal Investigator

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Lipid flippase is the novel therapeutic target for the Alzheimer disease, which correlate with endocytic traffic impairment.

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ALS病因タンパク質FUSの細胞間伝播及び神経細胞障害性発揮メカニズムの解明Principal Investigator

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Elucidation of the molecular mechanisms of Abeta economy in the brain of Alzheimer's disease

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Elucidation of the pathomechanism of neurodegeneration induced by TDP-43Principal Investigator

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Study for the metabolism and neurotoxicity of amyloid beta peptide oligomersPrincipal Investigator

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Elucidation of the molecular pathology of Alzheimer's disease focusing on the synapses toward therapies

Principal Investigator

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アルツハイマー病脳におけるアミロイド構成蛋白質CLACに関する研究Principal Investigator

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アルツハイマー病新規アミロイド構成蛋白質CLACに関する病態生化学的研究Principal Investigator

Principal Investigator

Project Period (FY)

HASHIMOTO TADAFUMI 橋本唯史

HASHIMOTO Tadafumi 橋本唯史