Shimozato Osamu 下里修

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SHIMOZATO Osamu 下里修

下里修シモザトオサム

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Researcher Number	30344063
Other IDs
Affiliation (Current)	2025: 千葉県がんセンター(研究所), がん予防センター精密腫瘍モデル研究室, 主任上席研究員
Affiliation (based on the past Project Information) *help	2023: 千葉県がんセンター(研究所), がん予防センター精密腫瘍モデル研究室, 主任上席研究員 2019 – 2023: 千葉県がんセンター(研究所), がん予防センター腫瘍ゲノム研究室, 室長 2018: 千葉県がんセンター(研究所), がん予防センター腫瘍ゲノム研究室, 室長心得 2016 – 2017: 千葉県がんセンター(研究所), 発がん研究グループ DNA損傷シグナル研究室, 上席研究員 2015: 千葉県がんセンター(研究所), DNA損傷シグナル研究室, 研究員 … More 2013 – 2015: 千葉県がんセンター(研究所), 研究所・発がん研究グループ, 上席研究員 2013: 千葉県がんセンター(研究所), 発がん研究グループ, 上席研究員 2013: 千葉県がんセンター, がん治療耐性克服研, 研究員 2011 – 2012: 千葉県がんセンター(研究所), 研究局・発がん研究グループ, 上席研究員 2010 – 2011: 千葉県がんセンター(研究所), 発がん研究グループ, 上席研究員 2009: Chiba Cancer Center (Research Institute), がん治療開発グループ, 研究員 2008: Chiba Cancer Center (Research Institute), 発がん研究グループ, 研究員 2007: Chiba Cancer Center (Research Institute), 生化学研究部, 研究員 2003: 千葉県がんセンター, 病理研究部, 研究員 2002: 千葉がんセンター, 病理研究部, 研究員 Less
Review Section/Research Field	Principal Investigator Experimental pathology / Basic Section 53010:Gastroenterology-related / Basic Section 56010:Neurosurgery-related / Digestive surgery / Immunology Except Principal Investigator Basic Section 55020:Digestive surgery-related / Digestive surgery / Medical pharmacy / General surgery
Keywords	Principal Investigator CD133 / 癌性幹細胞 / 癌幹細胞 / 大腸がん / PIポリアミド / HMGB転写因子ファミリー / 消化器がん / 脳腫瘍 / エピゲノム制御 / JHDM1B/KDM2B … More / 薬剤耐性 / JHDM1B / エピゲノム的制御 / 治療抵抗性 / スフェア形成 / 発生・分化 / 癌 / 幹細胞ニッチ / 腫瘍 / IL-13 / GATA-3 / 免疫応答制御 / Th2 / Th1 / Decoy DNA … More Except Principal Investigator がん予防 / SNP / ゲノム / がん / 癌性幹細胞 / 大腸がん / CD133 / ARID2遺伝子 / 胃がん / 大腸がん / ヒストンメチル化 / ヒストン脱メチル化 / KDM2B / 治療耐性 / 遺伝子 / がん個別化治療 / がん型OATP1B3 / Cancer-type OATP1B3 / がん遺伝子治療 / cancer-type OATP1B3 / PTPRK / 大腸癌 / ROS産生 / ＣＤ１３３ / 活性酸素種 / 癌幹細胞 / TRAIL receptor / 分子生物学 / Leukocytes / 細胞死 / 白血球 / 実験医学 / アポトーシス / ＩＦＮγ / ＴＮＦα / 好中球 / TRAIL受容体 / TRAIL / SIRS Less

HMGB転写因子ファミリーの包括的抑制による新規消化器がん治療薬開発の基盤研究Principal Investigator
- Principal Investigator
  
  下里修
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Chiba Cancer Center (Research Institute)
Functional analysis of a novel single nucleotide polymorphism within ARID2 gene associated with gastric cancer development.
- Principal Investigator
  
  NAKAMURA Yohko
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Chiba Cancer Center (Research Institute)
Elucidation of the Significance of KDM2B in Drug Resistance of Colorectal Cancer
- Principal Investigator
  
  Nakamura Yuki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Chiba Cancer Center (Research Institute)
Elucidation of the Significance of the CD133 Cluster in Treatment Resistance of Malignant Brain Tumors and Development of Novel TherapiesPrincipal Investigator
- Principal Investigator
  
  SHIMOZATO OSAMU
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Chiba Cancer Center (Research Institute)
Analysis of gastrointestinal cancer risk-related function SNP and its clinical application
- Principal Investigator
  
  Nakamura Yohko
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Chiba Cancer Center (Research Institute)
Fundamental research on drug resistance mediated by epigenetic regulation and novel colorectal cancer stem cell targeted therapyPrincipal Investigator
- Principal Investigator
  
  SHIMOZATO OSAMU
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Chiba Cancer Center (Research Institute)
Development of a novel RNA trans-splicing molecule for cancer gene therapy targeting to cancer-type organic anion transporting polypeptide 1B3
- Principal Investigator
  
  Furihata Tomomi
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  Chiba University
Functional analysis of PTPRK-CD133 regulatory axis in colon cancer progression.
- Principal Investigator
  
  Souda Hiroaki
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Chiba Cancer Center (Research Institute)
Molecular mechanisms behind the acquisition of multi-drug resistance in sphere-formed colon cancer cells.Principal Investigator
- Principal Investigator
  
  SHIMOZATO Osamu
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Chiba Cancer Center (Research Institute)
Regulation of systemic inflammatory response syndrome by TNF-related apoptosis inducing ligand which affect neutrophils exclusion and its potential clinical application.
- Principal Investigator
  
  KAMOHARA hidenobu
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Kumamoto University
Functional analysis of CD133 in the maintenance of stemness mediated by ROS production in colon cancer cell.
- Principal Investigator
  
  SOUDA Hiroaki
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Chiba Cancer Center (Research Institute)
Functional analysis of CD133in tumorigenesis and stemness of cancer stem cellPrincipal Investigator
- Principal Investigator
  
  SHIMOZATO Osamu
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Chiba Cancer Center (Research Institute)
Functional analysis of a stem cell marker CD133 in the construction of stem cell niche.Principal Investigator
- Principal Investigator
  
  SHIMOZATO Osamu
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Chiba Cancer Center (Research Institute)
Decoy DNAによるTh1/Th2サイトカインの発現調節と免疫応答制御の検討Principal Investigator
- Principal Investigator
  
  下里修
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  Chiba Cancer Center (Research Institute)

[Journal Article] CD133 prevents colon cancer cell death induced by serum deprivation through activation of Akt‐mediated protein synthesis and inhibition of apoptosis2021
- Author(s)
  Yusuke Mori (他7名) Osamu Shimozato
- Journal Title
  
  FEBS Open Bio
  
  Volume: 11 Issue: 5 Pages: 1382-1394
- DOI
  10.1002/2211-5463.13145
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09470
[Journal Article] Hydrophobic structure of hairpin ten-ring pyrrole-imidazole polyamides enhances tumor tissue accumulation/retention in vivo2018
- Author(s)
  Inoue Takahiro、Shimozato Osamu、Matsuo Nina、Mori Yusuke、Shinozaki Yoshinao、Lin Jason、Watanabe Takayoshi、Takatori Atsushi、Koshikawa Nobuko、Ozaki Toshinori、Nagase Hiroki
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 26 Issue: 9 Pages: 2337-2344
- DOI
  10.1016/j.bmc.2018.03.029
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10559, KAKENHI-PUBLICLY-16H01579, KAKENHI-PROJECT-16J05439, KAKENHI-PROJECT-15K08412, KAKENHI-PROJECT-17K15047, KAKENHI-PROJECT-17H03602
[Journal Article] Impact of RUNX2 gene silencing on the gemcitabine sensitivity of p53 mutated pancreatic cancer MiaPaCa 2 spheres.2018
- Author(s)
  Sang M, Nakamura M, Ogata T, Sun D, Shimozato O, Nikaido T, Ozaki T.
- Journal Title
  
  Oncol Rep.
  
  Volume: 印刷中 Pages: 2749-2758
- DOI
  10.3892/or.2018.6344
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04980, KAKENHI-PROJECT-15K08412, KAKENHI-PROJECT-16K10559
[Journal Article] Drug resistance of cancer stem cell.2017
- Author(s)
  Osamu Shimozato, Masashi Matsushita, Kyosuke Uchiumi, Yusuke Mori, Meijie Sang, Toshinori Ozaki
- Journal Title
  
  BIO Clinica
  
  Volume: 32 Pages: 53-58
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10559
[Journal Article] The role of tyrosine phosphorylation of cancer stem cell marker CD133 in malignant tumor progression2015
- Author(s)
  下里修（他2名）
- Journal Title
  
  Seikagaku
  
  Volume: 87 Pages: 389-392
- NAID
  40020519954
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26462033
[Journal Article] Receptor-type protein tyrosine phosphatasedirectly dephosphorylates CD133 and regulates downstream AKT activation2014
- Author(s)
  Shimozato O, Souda H
- Journal Title
  
  Oncogene
  
  Volume: 34(15) Issue: 15 Pages: 1-12
- DOI
  10.1038/onc.2014.141
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23591978, KAKENHI-PROJECT-24249061, KAKENHI-PROJECT-24390269, KAKENHI-PROJECT-26462721, KAKENHI-PROJECT-15K08412
[Journal Article] Expression of a murine homolog of apoptosis-inducing human IL-24/MDA-7 in murine tumors fails to induce apoptosis or produce anti-tumor effects2012
- Author(s)
  Nagakawa H, Shimozato O, 他9名
- Journal Title
  
  Cellular Immunol
  
  Volume: 275 Issue: 1-2 Pages: 90-97
- DOI
  10.1016/j.cellimm.2012.02.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790397, KAKENHI-PROJECT-23591951, KAKENHI-PROJECT-23591978, KAKENHI-PROJECT-24590496
[Journal Article] Expression of a murine homolog of apoptosis-inducing human IL-24/MDA-7 in murine tumors fails to induce apoptosis or produce anti-tumor effects.2012
- Author(s)
  Nagakawa H, Shimozato O (11名中2番目)
- Journal Title
  
  Cell Immunol.
  
  Volume: 275 Pages: 90-97
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591978
[Journal Article] CD133 suppresses neuroblastoma cell differentiation via signal pathway modification.2011
- Author(s)
  Takenobu H, Shimozato O, Nakamura T, Ochiai H, Yamaguchi Y, Ohira M, Nakagawara A, Kamijo T.
- Journal Title
  
  Oncogene
  
  Volume: 30 Pages: 97-105
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790397
[Journal Article] CD70 is selectively expressed on Th1 but not on Th2 cells and is required for Th1-type immune responses2011
- Author(s)
  Kawamura T, 他1名、Shimozato O, 他6名
- Journal Title
  
  J Invest Dermatol
  
  Volume: 131 Issue: 6 Pages: 1252-1261
- DOI
  10.1038/jid.2011.36
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790397, KAKENHI-PROJECT-23390260, KAKENHI-PROJECT-23591978
[Journal Article] CD133 suppresses neuroblastoma cell differentiation via signal pathway modification2011
- Author(s)
  Takenobu H, Shimozato O, Nakamura T, Ochiai H, Yamaguchi Y, Ohira M, Nakagawara A, Kamijo T
- Journal Title
  
  Oncogene
  
  Volume: 30 Issue: 1 Pages: 97-105
- DOI
  10.1038/onc.2010.383
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390317, KAKENHI-PROJECT-21591376, KAKENHI-PROJECT-21790397, KAKENHI-PROJECT-22680065, KAKENHI-PROJECT-22791017
[Journal Article] Bmi1 regulates cell fate via tumor suppressor WWOX repression in small cell lung cancer cells2011
- Author(s)
  Kimura M, Takenobu H, Akita N, Nakazawa A, Ochiai H, Shimozato O, Fujimura YI, Koseki H, Yoshino I, Kimura H, Nakagawara A, Kamijo T
- Journal Title
  
  Cancer Sci
  
  Volume: 102 Issue: 5 Pages: 983-990
- DOI
  10.1111/j.1349-7006.2011.01891.x
- NAID
  10029293384
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390317, KAKENHI-PROJECT-21790397, KAKENHI-PROJECT-22791017, KAKENHI-PROJECT-23591978
[Presentation] Cell-free DNA bearing mutated KRAS gene is an unsuitable genetic marker for the early diagnosis of pancreatic cancer.2023
- Author(s)
  下里修、北川善康、他5名
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-23K07408
[Presentation] An epigenetic regulation of drug resistant genes by KDM2B in colon cancer cells exposed to anti-tumor drugs.2022
- Author(s)
  下里　修、（他2名）、中村友紀
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K09092
[Presentation] CD133 prevents serum deprivation-induced colon cancer cell death through the activation of mTORC1 and Bad by AKT.2021
- Author(s)
  宮川絢伍、森祐輔、中村友紀、巽康年、下里修
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K09470
[Presentation] Histone demethylase KDM2B epigenetically counteracts multidrug resistance in colon cancer cells2020
- Author(s)
  A. Takeuchi, （他3名）O. Shimozato
- Organizer
  日本癌学会学術総会（第79回）
- Data Source
  KAKENHI-PROJECT-20K09092
[Presentation] ヒストン脱メチル化酵素KDM2Bによる大腸がん細胞のFOLFOX療法耐性獲得2020
- Author(s)
  A. Takeuchi, （他3名）O. Shimozato
- Organizer
  日本癌病態治療研究会（第29回）
- Data Source
  KAKENHI-PROJECT-20K09092
[Presentation] 新規 KDM2B-AKR1B1経路は大腸がん細胞の多剤耐性獲得に寄与する2020
- Author(s)
  A. Takeuchi,（他3名） , O. Shimozato
- Organizer
  日本分子生物学会年会（第43回）
- Data Source
  KAKENHI-PROJECT-20K09092
[Presentation] A cancer stem cell marker CD133 suppresses colon cancer cell death triggered by serum deprivation.2019
- Author(s)
  下里　修
- Organizer
  日本癌学会
- Data Source
  KAKENHI-PROJECT-19K09470
[Presentation] 疎水性を高める1次構造はヘアピン型ピロールイミダゾールポリアミドが有する腫瘍集積性を高める2018
- Author(s)
  下里　修
- Organizer
  第77回日本癌学会学術集会
- Data Source
  KAKENHI-PROJECT-16K10559
[Presentation] スフェア培養を用いたがん幹細胞が有する悪性形質獲得機構の解明2017
- Author(s)
  下里　修、早田浩明、尾崎俊文
- Organizer
  第16回日本再生医療学会総会
- Place of Presentation
  仙台国際センター
- Year and Date
  2017-03-07
- Invited
- Data Source
  KAKENHI-PROJECT-16K10559
[Presentation] DNA副溝結合性化合物pyrrole-imidazole polyamideの能動輸送を介したがん細胞内移行メカニズム2017
- Author(s)
  森祐輔、下里修、早田浩明、内海京寛、井上貴博、篠崎喜脩、渡部隆義、永瀬浩喜、尾崎俊文
- Organizer
  第26回日本癌病態治療研究会
- Data Source
  KAKENHI-PROJECT-16K10559
[Presentation] The hydrophobicity influences the pharmacokinetic property of a DNA minor-grove binder PIP in vivo.2017
- Author(s)
  T. Inoue, O. Shimozato, N. Matsuo, Y. Shinozaki, T. Watanabe, A. Takatori, N. Koshikawa, T. Ozaki, H. Nagase
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16K10559
[Presentation] Lipophilicity is a critical determinant essential for the efficient incorporation of pyrrole-imidazole polyamides into malignant tumor tissues2017
- Author(s)
  井上貴博、下里　修、尾崎俊文
- Organizer
  International symposium for the drug-discovery of the pyrrole-imidazole polyamides as novel biomedicines
- Place of Presentation
  日本大学桜門会館
- Year and Date
  2017-02-24
- Data Source
  KAKENHI-PROJECT-16K10559
[Presentation] Internalization of DNA minor groove binder pyrrole-imidazole polyamide into cancer cells via active transport machineries2017
- Author(s)
  下里　修、尾崎俊文
- Organizer
  International symposium for the drug-discovery of the pyrrole-imidazole polyamides as novel biomedicines
- Place of Presentation
  日本大学桜門会館
- Year and Date
  2017-02-24
- Data Source
  KAKENHI-PROJECT-16K10559
[Presentation] Internalization of DNA minor groove binder pyrrole-imidazole polyamide into cancer cells via actin-dependent mechanism2016
- Author(s)
  下里　修、早田浩明、尾崎俊文
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-10-08
- Data Source
  KAKENHI-PROJECT-16K10559
[Presentation] スフェア形成能を有する大腸がん細胞のエピゲノム的薬剤耐性機構の解析2016
- Author(s)
  内海京寛、下里　修、早田浩明、尾崎俊文
- Organizer
  第25回日本病態治療研究会
- Place of Presentation
  三井ガーデンホテル千葉
- Year and Date
  2016-06-08
- Data Source
  KAKENHI-PROJECT-16K10559
[Presentation] PTPRKによるがん幹細胞マーカーCD133の脱リン酸化を介した大腸がん進展の抑制2016
- Author(s)
  松下雅司、下里　修、早田浩明
- Organizer
  第25回日本癌病態治療研究会
- Place of Presentation
  三井ガーデンホテル千葉
- Year and Date
  2016-06-08
- Data Source
  KAKENHI-PROJECT-26462033
[Presentation] 新規がん診断分子候補Ct-OATP1B3 mRNAはがん由来エキソソームに内包される2016
- Author(s)
  井手秀行、孫雨晨、原田まなみ、下里修、上條岳彦、山口直人、千葉寬、秋田英万、安西尚彦、降幡知巳
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（横浜市・神奈川県）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-15K14994
[Presentation] Receptor-type protein tyrosine phosphatase PTPRK attenuates CD133-mediated tumorigenesis of colon cancer cells through the down-regulation of pro-oncogenic CD133-PI3K-AKT pathway.2015
- Author(s)
  早田浩明（7人中3番目）、下里修（7人中2番目）
- Organizer
  日本分子生物学会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26462033
[Presentation] 膜結合型チロシン脱リン酸化酵素PTPRKによるチロシン脱リン酸化はがん幹細胞マーカーCD133のAKT/b-catenin経路を介した発がん機構を負に制御する2013
- Author(s)
  藁谷美雪、下里　修、早田浩明、（他3名）、上條岳彦
- Organizer
  第36回分子生物学会
- Place of Presentation
  神戸国際会議場
- Data Source
  KAKENHI-PROJECT-24590496
[Presentation] 膜結合型チロシン脱リン酸化酵素PTPRKによるチロシン脱リン酸化はがん幹細胞マーカーCD133の機構を負に制御する2013
- Author(s)
  下里修, 早田浩明, （他4名）
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-23591978
[Presentation] Functional p53 inactivation in neuroblastoma: novel 1p tumor suppressor DMAP1 regulates MYCN/ATM/p53 pathway2013
- Author(s)
  Y Yamaguchi、（他1名）、下里　修、（他2名）、T Kamijo
- Organizer
  第6回ｐ63/ｐ73国際シンポジウム
- Place of Presentation
  かずさアカデミアパーク
- Data Source
  KAKENHI-PROJECT-24590496
[Presentation] 膜結合型チロシン脱リン酸化酵素PTPRKによるチロシン脱リン酸化はがん幹細胞マーカーCD133の機能を負に制御する2013
- Author(s)
  下里修、早田浩明(他4名)
- Organizer
  第72回日本癌学会学術集会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-23591978
[Presentation] 大腸がん由来spheroid細胞はエピゲノム的制御によるABCB1遺伝子の発現上昇によって多剤耐性を獲得する2013
- Author(s)
  上原悠, 下里修, 藁谷美雪, 早田浩明,（他2名）、上條岳彦
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-24590496
[Presentation] Sphere formation produces multi-drug resistancce in human colon cancer cells via histone modification of ABCB1 promoter.2012
- Author(s)
  下里　修、（他4名）、上條　岳彦
- Organizer
  第71回日本癌学会学術集会
- Place of Presentation
  ロイトン札幌、札幌芸文館、札幌市教育文化会館
- Data Source
  KAKENHI-PROJECT-24590496
[Presentation] Tumor sphere specific CD133 regulation in neuroblastoma2011
- Author(s)
  竹信尚典、下里修, 他5名
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2011-10-03
- Data Source
  KAKENHI-PROJECT-21790397
[Presentation] CD133 plays roles in keeping the undifferentiated status of human colon cancer cells via PI3K/AKT activation.2011
- Author(s)
  下里　修（他5名）
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場
- Data Source
  KAKENHI-PROJECT-23591978
[Presentation] CD133plays roles in keeping the undifferentiated status of human colon cancer cells via PI3K/AKT activation2011
- Author(s)
  下里修(他5名)
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2011-10-03
- Data Source
  KAKENHI-PROJECT-21790397
[Presentation] Acquired multi-drug resistance in human colon cancer cells by sphere Formation.2011
- Author(s)
  中島久美子、下里　修（他4名）
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場
- Data Source
  KAKENHI-PROJECT-23591978
[Presentation] CD133 plays roles in keeping the undifferentiated status of human colon cancer cells via PI3K/AKT activation2011
- Author(s)
  下里修, 他5名
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2011-10-03
- Data Source
  KAKENHI-PROJECT-21790397
[Presentation] Tumor sphere specific CD133 regulation in neuroblastoma.2011
- Author(s)
  竹信尚典、下里　修（他5名）
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場
- Data Source
  KAKENHI-PROJECT-23591978
[Presentation] CD133 plays roles in keeping the undifferentiated status of human colon cancer cells via PI3K/AKT activation2011
- Author(s)
  下里修(他5名)
- Organizer
  第70回日本癌学会学術集会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2011-10-03
- Data Source
  KAKENHI-PROJECT-23591978
[Presentation] Acquired multi-drug resistance in human colon cancer cells by sphere Formation2011
- Author(s)
  中島久美子、下里修, 他4名
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2011-10-03
- Data Source
  KAKENHI-PROJECT-21790397
[Presentation] GATA-6 transactivates a novel promoter for stem cell marker CD133 gene in human colorectal cancer cells.2010
- Author(s)
  下里修, (他5名)
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪国際会議場
- Year and Date
  2010-09-23
- Data Source
  KAKENHI-PROJECT-21790397
[Presentation] CD 133 regulates neuroblastoma stemness via p38MAPK and PI3K/Akt activation.2010
- Author(s)
  竹信尚典、下里修, (他5名)
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪国際会議場
- Year and Date
  2010-09-23
- Data Source
  KAKENHI-PROJECT-21790397
[Presentation] GATA-6transactivates a novel promoter for stem cell marker CD133gene in human colorectal cancer cells2010
- Author(s)
  下里修(他5名)
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪国際会議場
- Year and Date
  2010-09-23
- Data Source
  KAKENHI-PROJECT-21790397
[Presentation] 幹細胞マーカーCDI33分子はβ-cateninの制御を通じて大腸がん細胞の腫瘍形成を亢進する2009
- Author(s)
  下里修
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  神奈川県横浜市パシフィコ横浜
- Year and Date
  2009-10-01
- Data Source
  KAKENHI-PROJECT-21790397
[Presentation] 幹細胞マーカーCD133分子はβ-cateninの制御を通じて大腸がん細胞の腫瘍形成を亢進する2009
- Author(s)
  下里修(他5名)
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  神奈川県横浜市パシフィコ横浜
- Year and Date
  2009-10-01
- Data Source
  KAKENHI-PROJECT-21790397
[Presentation] 神経芽腫細胞における造腫瘍能を担う幹細胞マーカーCD133分子の機能ドメインの解析2008
- Author(s)
  下里修
- Organizer
  第24回日小児がん学会学術総会
- Place of Presentation
  千葉県千葉市幕張メッセ
- Year and Date
  2008-11-14
- Data Source
  KAKENHI-PROJECT-19790300
[Presentation] 大腸がん細胞株の分化誘導とがん形成における幹細胞マーカーCD133分子の機能解析2008
- Author(s)
  下里修
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  愛知県名古屋市名古屋国際会議場
- Year and Date
  2008-10-29
- Data Source
  KAKENHI-PROJECT-19790300
[Presentation] 神経芽腫細胞における造腫瘍能を担う幹細胞マーカーCD133分子の機能ドメインの解析2008
- Author(s)
  下里修(6名中1番)
- Organizer
  第24回日小児がん学会学術総会
- Place of Presentation
  千葉県千葉市・幕張メッセ
- Year and Date
  2008-11-14
- Data Source
  KAKENHI-PROJECT-19790300
[Presentation] 大腸がん細胞株の分化誘導とがん形成における幹細胞マーカーCD133分子の機能解析2008
- Author(s)
  下里修(6名中1番)
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  愛知県名古屋市・名古屋国際会議場
- Year and Date
  2008-10-29
- Data Source
  KAKENHI-PROJECT-19790300
[Presentation] Antibody against cancer stem cell marker CD133 down-regulates cell cycle progression in colon cancer cells2007
- Author(s)
  下里修(4名中1番)
- Organizer
  第66回日本癌学会学術総会
- Place of Presentation
  神奈川県横浜市・パシフィコ横浜
- Year and Date
  2007-10-03
- Data Source
  KAKENHI-PROJECT-19790300
[Presentation] Antibody against cancer stem cell marker CD133 down-regulates cell cycle progression in colon cancer cells2007
- Author(s)
  下里修
- Organizer
  第66回日本癌学会学術絵会
- Place of Presentation
  神奈川県横浜市パシフィコ横浜
- Year and Date
  2007-10-03
- Data Source
  KAKENHI-PROJECT-19790300
[Presentation] 受容体型蛋白質チロシン脱リン酸化酵素PTPRKはCD133を脱リン酸化し、その下流に繋がるAKT経路の活性化を鎮静化する
- Author(s)
  下里　修（７人中１番目）、早田浩明（７人中２番目）、上條岳彦（７人中５番目）
- Organizer
  第７３回日本癌学会学術集会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-26462033
[Presentation] ヒストン脱メチル化酵素JHDM1Bは大腸がんスフェア細胞のABCB1依存的な薬剤耐性獲得を阻害する
- Author(s)
  下里　修（７人中２番目）、早田浩明（７人中３番目）、上條岳彦（７人中５番目）
- Organizer
  第７３回日本癌学会学術集会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-24590496
[Presentation] ヒストン脱メチル化酵素JHDM1Bは大腸がんスフェア細胞の多剤耐性獲得を阻害する
- Author(s)
  下里　修（5人中2番目）、早田浩明（5人中3番目）
- Organizer
  第３７回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-24590496

1. SOUDA Hiroaki (90261940)

# of Collaborated Projects: 4 results

# of Collaborated Products: 14 results
2. KAMIJO Takehiko (90262708)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
3. Nakamura Yohko (60260254)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
4. 巽康年 (00450578)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. KAMOHARA hidenobu (90398222)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. KINOSHITA Yoshihiro (30195341)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. SAGISHIMA Katsuyuki (40336235)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. HIROSAKO Susumu (70432995)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. SAKAI Keisuke (10433038)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. ARAKAWA Hirofumi (70313088)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. Furihata Tomomi (80401008)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. Nakamura Yuki (50869287)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
13. 尾崎俊文 (40260252)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
14. 井内俊彦 (80370881)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 石毛文隆 (60815801)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 北川善康 (10838577)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
17. 中川原章

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
18. 二階堂敏雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Shimozato Osamu 下里 修

SHIMOZATO Osamu 下里 修

下里 修 シモザト オサム

Research Projects

Research Products

Co-Researchers

HMGB転写因子ファミリーの包括的抑制による新規消化器がん治療薬開発の基盤研究Principal Investigator

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Functional analysis of a novel single nucleotide polymorphism within ARID2 gene associated with gastric cancer development.

Principal Investigator

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Review Section

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Elucidation of the Significance of KDM2B in Drug Resistance of Colorectal Cancer

Principal Investigator

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Review Section

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Elucidation of the Significance of the CD133 Cluster in Treatment Resistance of Malignant Brain Tumors and Development of Novel TherapiesPrincipal Investigator

Principal Investigator

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Analysis of gastrointestinal cancer risk-related function SNP and its clinical application

Principal Investigator

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Review Section

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Fundamental research on drug resistance mediated by epigenetic regulation and novel colorectal cancer stem cell targeted therapyPrincipal Investigator

Principal Investigator

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Development of a novel RNA trans-splicing molecule for cancer gene therapy targeting to cancer-type organic anion transporting polypeptide 1B3

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Functional analysis of PTPRK-CD133 regulatory axis in colon cancer progression.

Principal Investigator

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Molecular mechanisms behind the acquisition of multi-drug resistance in sphere-formed colon cancer cells.Principal Investigator

Principal Investigator

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Regulation of systemic inflammatory response syndrome by TNF-related apoptosis inducing ligand which affect neutrophils exclusion and its potential clinical application.

Principal Investigator

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Functional analysis of CD133 in the maintenance of stemness mediated by ROS production in colon cancer cell.

Principal Investigator

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Functional analysis of CD133in tumorigenesis and stemness of cancer stem cellPrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

Functional analysis of a stem cell marker CD133 in the construction of stem cell niche.Principal Investigator

Principal Investigator

Shimozato Osamu 下里修

SHIMOZATO Osamu 下里修

下里修シモザトオサム