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Shimozato Osamu  下里 修

ORCIDConnect your ORCID iD *help
… Alternative Names

SHIMOZATO Osamu  下里 修

下里 修  シモザト オサム

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Researcher Number 30344063
Other IDs
Affiliation (Current) 2026: 千葉県がんセンター(研究所), がん予防センター 臨床腫瘍生物学研究室, 室長
Affiliation (based on the past Project Information) *help 2026: 千葉県がんセンター(研究所), がん予防センター 精密腫瘍モデル研究室, 主任上席研究員
2023 – 2024: 千葉県がんセンター(研究所), がん予防センター 精密腫瘍モデル研究室, 主任上席研究員
2019 – 2023: 千葉県がんセンター(研究所), がん予防センター 腫瘍ゲノム研究室, 室長
2018: 千葉県がんセンター(研究所), がん予防センター 腫瘍ゲノム研究室, 室長心得
2016 – 2017: 千葉県がんセンター(研究所), 発がん研究グループ DNA損傷シグナル研究室, 上席研究員 … More
2015: 千葉県がんセンター(研究所), DNA損傷シグナル研究室, 研究員
2013 – 2015: 千葉県がんセンター(研究所), 研究所・発がん研究グループ, 上席研究員
2013: 千葉県がんセンター(研究所), 発がん研究グループ, 上席研究員
2013: 千葉県がんセンター, がん治療耐性克服研, 研究員
2011 – 2012: 千葉県がんセンター(研究所), 研究局・発がん研究グループ, 上席研究員
2010 – 2011: 千葉県がんセンター(研究所), 発がん研究グループ, 上席研究員
2009: Chiba Cancer Center (Research Institute), がん治療開発グループ, 研究員
2008: Chiba Cancer Center (Research Institute), 発がん研究グループ, 研究員
2007: Chiba Cancer Center (Research Institute), 生化学研究部, 研究員
2003: 千葉県がんセンター, 病理研究部, 研究員
2002: 千葉がんセンター, 病理研究部, 研究員 Less
Review Section/Research Field
Principal Investigator
Experimental pathology / Basic Section 50010:Tumor biology-related / Basic Section 53010:Gastroenterology-related / Basic Section 56010:Neurosurgery-related / Digestive surgery / Immunology
Except Principal Investigator
Basic Section 55020:Digestive surgery-related / Digestive surgery / Medical pharmacy / General surgery
Keywords
Principal Investigator
CD133 / 癌性幹細胞 / 癌幹細胞 / 大腸がん / PIポリアミド / HMGB転写因子ファミリー / 消化器がん / 脳腫瘍 / エピゲノム制御 / JHDM1B/KDM2B … More / 薬剤耐性 / JHDM1B / エピゲノム的制御 / 治療抵抗性 / スフェア形成 / 発生・分化 / 癌 / 幹細胞ニッチ / 腫瘍 / IL-13 / GATA-3 / 免疫応答制御 / Th2 / Th1 / Decoy DNA … More
Except Principal Investigator
がん予防 / SNP / ゲノム / がん / 癌性幹細胞 / 大腸がん / CD133 / ARID2遺伝子 / 胃がん / 大腸がん / ヒストンメチル化 / ヒストン脱メチル化 / KDM2B / 治療耐性 / 遺伝子 / がん個別化治療 / がん型OATP1B3 / Cancer-type OATP1B3 / がん遺伝子治療 / cancer-type OATP1B3 / PTPRK / 大腸癌 / ROS産生 / CD133 / 活性酸素種 / 癌幹細胞 / TRAIL receptor / 分子生物学 / Leukocytes / 細胞死 / 白血球 / 実験医学 / アポトーシス / IFNγ / TNFα / 好中球 / TRAIL受容体 / TRAIL / SIRS Less
  • Research Projects

    (15 results)
  • Research Products

    (59 results)
  • Co-Researchers

    (18 People)
  •  消化器がん経験者に高頻度で検出されたがん抑制遺伝子のSNPが腫瘍免疫に及ぼす影響Principal Investigator

    • Principal Investigator
      下里 修
    • Project Period (FY)
      2026 – 2028
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50010:Tumor biology-related
    • Research Institution
      Chiba Cancer Center (Research Institute)
  •  HMGB転写因子ファミリーの包括的抑制による新規消化器がん治療薬開発の基盤研究Principal Investigator

    • Principal Investigator
      下里 修
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      Chiba Cancer Center (Research Institute)
  •  Functional analysis of a novel single nucleotide polymorphism within ARID2 gene associated with gastric cancer development.

    • Principal Investigator
      NAKAMURA Yohko
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      Chiba Cancer Center (Research Institute)
  •  Elucidation of the Significance of KDM2B in Drug Resistance of Colorectal Cancer

    • Principal Investigator
      Nakamura Yuki
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      Chiba Cancer Center (Research Institute)
  •  Elucidation of the Significance of the CD133 Cluster in Treatment Resistance of Malignant Brain Tumors and Development of Novel TherapiesPrincipal Investigator

    • Principal Investigator
      SHIMOZATO OSAMU
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56010:Neurosurgery-related
    • Research Institution
      Chiba Cancer Center (Research Institute)
  •  Analysis of gastrointestinal cancer risk-related function SNP and its clinical application

    • Principal Investigator
      Nakamura Yohko
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      Chiba Cancer Center (Research Institute)
  •  Fundamental research on drug resistance mediated by epigenetic regulation and novel colorectal cancer stem cell targeted therapyPrincipal Investigator

    • Principal Investigator
      SHIMOZATO OSAMU
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Chiba Cancer Center (Research Institute)
  •  Development of a novel RNA trans-splicing molecule for cancer gene therapy targeting to cancer-type organic anion transporting polypeptide 1B3

    • Principal Investigator
      Furihata Tomomi
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Medical pharmacy
    • Research Institution
      Chiba University
  •  Functional analysis of PTPRK-CD133 regulatory axis in colon cancer progression.

    • Principal Investigator
      Souda Hiroaki
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Chiba Cancer Center (Research Institute)
  •  Molecular mechanisms behind the acquisition of multi-drug resistance in sphere-formed colon cancer cells.Principal Investigator

    • Principal Investigator
      SHIMOZATO Osamu
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Experimental pathology
    • Research Institution
      Chiba Cancer Center (Research Institute)
  •  Regulation of systemic inflammatory response syndrome by TNF-related apoptosis inducing ligand which affect neutrophils exclusion and its potential clinical application.

    • Principal Investigator
      KAMOHARA hidenobu
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General surgery
    • Research Institution
      Kumamoto University
  •  Functional analysis of CD133 in the maintenance of stemness mediated by ROS production in colon cancer cell.

    • Principal Investigator
      SOUDA Hiroaki
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Chiba Cancer Center (Research Institute)
  •  Functional analysis of CD133in tumorigenesis and stemness of cancer stem cellPrincipal Investigator

    • Principal Investigator
      SHIMOZATO Osamu
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Experimental pathology
    • Research Institution
      Chiba Cancer Center (Research Institute)
  •  Functional analysis of a stem cell marker CD133 in the construction of stem cell niche.Principal Investigator

    • Principal Investigator
      SHIMOZATO Osamu
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Experimental pathology
    • Research Institution
      Chiba Cancer Center (Research Institute)
  •  Decoy DNAによるTh1/Th2サイトカインの発現調節と免疫応答制御の検討Principal Investigator

    • Principal Investigator
      下里 修
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Immunology
    • Research Institution
      Chiba Cancer Center (Research Institute)

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 Other

All Journal Article Presentation

  • [Journal Article] CD133 prevents colon cancer cell death induced by serum deprivation through activation of Akt‐mediated protein synthesis and inhibition of apoptosis2021

    • Author(s)
      Yusuke Mori (他7名) Osamu Shimozato
    • Journal Title

      FEBS Open Bio

      Volume: 11 Issue: 5 Pages: 1382-1394

    • DOI

      10.1002/2211-5463.13145

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K09470
  • [Journal Article] Hydrophobic structure of hairpin ten-ring pyrrole-imidazole polyamides enhances tumor tissue accumulation/retention in vivo2018

    • Author(s)
      Inoue Takahiro、Shimozato Osamu、Matsuo Nina、Mori Yusuke、Shinozaki Yoshinao、Lin Jason、Watanabe Takayoshi、Takatori Atsushi、Koshikawa Nobuko、Ozaki Toshinori、Nagase Hiroki
    • Journal Title

      Bioorganic & Medicinal Chemistry

      Volume: 26 Issue: 9 Pages: 2337-2344

    • DOI

      10.1016/j.bmc.2018.03.029

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K10559, KAKENHI-PUBLICLY-16H01579, KAKENHI-PROJECT-16J05439, KAKENHI-PROJECT-15K08412, KAKENHI-PROJECT-17K15047, KAKENHI-PROJECT-17H03602
  • [Journal Article] Impact of RUNX2 gene silencing on the gemcitabine sensitivity of p53 mutated pancreatic cancer MiaPaCa 2 spheres.2018

    • Author(s)
      Sang M, Nakamura M, Ogata T, Sun D, Shimozato O, Nikaido T, Ozaki T.
    • Journal Title

      Oncol Rep.

      Volume: 印刷中 Pages: 2749-2758

    • DOI

      10.3892/or.2018.6344

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04980, KAKENHI-PROJECT-15K08412, KAKENHI-PROJECT-16K10559
  • [Journal Article] Drug resistance of cancer stem cell.2017

    • Author(s)
      Osamu Shimozato, Masashi Matsushita, Kyosuke Uchiumi, Yusuke Mori, Meijie Sang, Toshinori Ozaki
    • Journal Title

      BIO Clinica

      Volume: 32 Pages: 53-58

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K10559
  • [Journal Article] The role of tyrosine phosphorylation of cancer stem cell marker CD133 in malignant tumor progression2015

    • Author(s)
      下里修(他2名)
    • Journal Title

      Seikagaku

      Volume: 87 Pages: 389-392

    • NAID

      40020519954

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26462033
  • [Journal Article] Receptor-type protein tyrosine phosphatasedirectly dephosphorylates CD133 and regulates downstream AKT activation2014

    • Author(s)
      Shimozato O, Souda H
    • Journal Title

      Oncogene

      Volume: 34(15) Issue: 15 Pages: 1-12

    • DOI

      10.1038/onc.2014.141

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23591978, KAKENHI-PROJECT-24249061, KAKENHI-PROJECT-24390269, KAKENHI-PROJECT-26462721, KAKENHI-PROJECT-15K08412
  • [Journal Article] Expression of a murine homolog of apoptosis-inducing human IL-24/MDA-7 in murine tumors fails to induce apoptosis or produce anti-tumor effects2012

    • Author(s)
      Nagakawa H, Shimozato O, 他9名
    • Journal Title

      Cellular Immunol

      Volume: 275 Issue: 1-2 Pages: 90-97

    • DOI

      10.1016/j.cellimm.2012.02.010

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790397, KAKENHI-PROJECT-23591951, KAKENHI-PROJECT-23591978, KAKENHI-PROJECT-24590496
  • [Journal Article] Expression of a murine homolog of apoptosis-inducing human IL-24/MDA-7 in murine tumors fails to induce apoptosis or produce anti-tumor effects.2012

    • Author(s)
      Nagakawa H, Shimozato O (11名中2番目)
    • Journal Title

      Cell Immunol.

      Volume: 275 Pages: 90-97

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591978
  • [Journal Article] CD133 suppresses neuroblastoma cell differentiation via signal pathway modification.2011

    • Author(s)
      Takenobu H, Shimozato O, Nakamura T, Ochiai H, Yamaguchi Y, Ohira M, Nakagawara A, Kamijo T.
    • Journal Title

      Oncogene

      Volume: 30 Pages: 97-105

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790397
  • [Journal Article] CD70 is selectively expressed on Th1 but not on Th2 cells and is required for Th1-type immune responses2011

    • Author(s)
      Kawamura T, 他1名、Shimozato O, 他6名
    • Journal Title

      J Invest Dermatol

      Volume: 131 Issue: 6 Pages: 1252-1261

    • DOI

      10.1038/jid.2011.36

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790397, KAKENHI-PROJECT-23390260, KAKENHI-PROJECT-23591978
  • [Journal Article] CD133 suppresses neuroblastoma cell differentiation via signal pathway modification2011

    • Author(s)
      Takenobu H, Shimozato O, Nakamura T, Ochiai H, Yamaguchi Y, Ohira M, Nakagawara A, Kamijo T
    • Journal Title

      Oncogene

      Volume: 30 Issue: 1 Pages: 97-105

    • DOI

      10.1038/onc.2010.383

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390317, KAKENHI-PROJECT-21591376, KAKENHI-PROJECT-21790397, KAKENHI-PROJECT-22680065, KAKENHI-PROJECT-22791017
  • [Journal Article] Bmi1 regulates cell fate via tumor suppressor WWOX repression in small cell lung cancer cells2011

    • Author(s)
      Kimura M, Takenobu H, Akita N, Nakazawa A, Ochiai H, Shimozato O, Fujimura YI, Koseki H, Yoshino I, Kimura H, Nakagawara A, Kamijo T
    • Journal Title

      Cancer Sci

      Volume: 102 Issue: 5 Pages: 983-990

    • DOI

      10.1111/j.1349-7006.2011.01891.x

    • NAID

      10029293384

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390317, KAKENHI-PROJECT-21790397, KAKENHI-PROJECT-22791017, KAKENHI-PROJECT-23591978
  • [Presentation] Anti-cancer potential of the novel pyrrole-imidazole polyamide against TCF/LEF transcription factors2024

    • Author(s)
      下里修、他6名
    • Organizer
      第83回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-23K07408
  • [Presentation] Cell-free DNA bearing mutated KRAS gene is an unsuitable genetic marker for the early diagnosis of pancreatic cancer.2023

    • Author(s)
      下里修、北川善康、他5名
    • Organizer
      第82回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-23K07408
  • [Presentation] An epigenetic regulation of drug resistant genes by KDM2B in colon cancer cells exposed to anti-tumor drugs.2022

    • Author(s)
      下里 修、(他2名)、中村友紀
    • Organizer
      第81回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-20K09092
  • [Presentation] CD133 prevents serum deprivation-induced colon cancer cell death through the activation of mTORC1 and Bad by AKT.2021

    • Author(s)
      宮川絢伍、森祐輔、中村友紀、巽康年、下里修
    • Organizer
      第80回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-19K09470
  • [Presentation] Histone demethylase KDM2B epigenetically counteracts multidrug resistance in colon cancer cells2020

    • Author(s)
      A. Takeuchi, (他3名)O. Shimozato
    • Organizer
      日本癌学会学術総会(第79回)
    • Data Source
      KAKENHI-PROJECT-20K09092
  • [Presentation] ヒストン脱メチル化酵素KDM2Bによる大腸がん細胞のFOLFOX療法耐性獲得2020

    • Author(s)
      A. Takeuchi, (他3名)O. Shimozato
    • Organizer
      日本癌病態治療研究会(第29回)
    • Data Source
      KAKENHI-PROJECT-20K09092
  • [Presentation] 新規 KDM2B-AKR1B1経路は大腸がん細胞の多剤耐性獲得に寄与する2020

    • Author(s)
      A. Takeuchi,(他3名) , O. Shimozato
    • Organizer
      日本分子生物学会年会(第43回)
    • Data Source
      KAKENHI-PROJECT-20K09092
  • [Presentation] A cancer stem cell marker CD133 suppresses colon cancer cell death triggered by serum deprivation.2019

    • Author(s)
      下里 修
    • Organizer
      日本癌学会
    • Data Source
      KAKENHI-PROJECT-19K09470
  • [Presentation] 疎水性を高める1次構造はヘアピン型ピロールイミダゾールポリアミドが有する腫瘍集積性を高める2018

    • Author(s)
      下里 修
    • Organizer
      第77回日本癌学会学術集会
    • Data Source
      KAKENHI-PROJECT-16K10559
  • [Presentation] スフェア培養を用いたがん幹細胞が有する悪性形質獲得機構の解明2017

    • Author(s)
      下里 修、早田浩明、尾崎俊文
    • Organizer
      第16回日本再生医療学会総会
    • Place of Presentation
      仙台国際センター
    • Year and Date
      2017-03-07
    • Invited
    • Data Source
      KAKENHI-PROJECT-16K10559
  • [Presentation] DNA副溝結合性化合物pyrrole-imidazole polyamideの能動輸送を介したがん細胞内移行メカニズム2017

    • Author(s)
      森祐輔、下里修、早田浩明、内海京寛、井上貴博、篠崎喜脩、渡部隆義、永瀬浩喜、尾崎俊文
    • Organizer
      第26回日本癌病態治療研究会
    • Data Source
      KAKENHI-PROJECT-16K10559
  • [Presentation] The hydrophobicity influences the pharmacokinetic property of a DNA minor-grove binder PIP in vivo.2017

    • Author(s)
      T. Inoue, O. Shimozato, N. Matsuo, Y. Shinozaki, T. Watanabe, A. Takatori, N. Koshikawa, T. Ozaki, H. Nagase
    • Organizer
      第76回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-16K10559
  • [Presentation] Lipophilicity is a critical determinant essential for the efficient incorporation of pyrrole-imidazole polyamides into malignant tumor tissues2017

    • Author(s)
      井上貴博、下里 修、尾崎俊文
    • Organizer
      International symposium for the drug-discovery of the pyrrole-imidazole polyamides as novel biomedicines
    • Place of Presentation
      日本大学桜門会館
    • Year and Date
      2017-02-24
    • Data Source
      KAKENHI-PROJECT-16K10559
  • [Presentation] Internalization of DNA minor groove binder pyrrole-imidazole polyamide into cancer cells via active transport machineries2017

    • Author(s)
      下里 修、尾崎俊文
    • Organizer
      International symposium for the drug-discovery of the pyrrole-imidazole polyamides as novel biomedicines
    • Place of Presentation
      日本大学桜門会館
    • Year and Date
      2017-02-24
    • Data Source
      KAKENHI-PROJECT-16K10559
  • [Presentation] Internalization of DNA minor groove binder pyrrole-imidazole polyamide into cancer cells via actin-dependent mechanism2016

    • Author(s)
      下里 修、早田浩明、尾崎俊文
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-10-08
    • Data Source
      KAKENHI-PROJECT-16K10559
  • [Presentation] スフェア形成能を有する大腸がん細胞のエピゲノム的薬剤耐性機構の解析2016

    • Author(s)
      内海京寛、下里 修、早田浩明、尾崎俊文
    • Organizer
      第25回日本病態治療研究会
    • Place of Presentation
      三井ガーデンホテル千葉
    • Year and Date
      2016-06-08
    • Data Source
      KAKENHI-PROJECT-16K10559
  • [Presentation] PTPRKによるがん幹細胞マーカーCD133の脱リン酸化を介した大腸がん進展の抑制2016

    • Author(s)
      松下雅司、下里 修、早田浩明
    • Organizer
      第25回日本癌病態治療研究会
    • Place of Presentation
      三井ガーデンホテル千葉
    • Year and Date
      2016-06-08
    • Data Source
      KAKENHI-PROJECT-26462033
  • [Presentation] 新規がん診断分子候補Ct-OATP1B3 mRNAはがん由来エキソソームに内包される2016

    • Author(s)
      井手秀行、 孫雨晨、 原田まなみ、 下里修、 上條岳彦、 山口直人、 千葉寬、 秋田英万、 安西尚彦、 降幡知巳
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(横浜市・神奈川県)
    • Year and Date
      2016-11-30
    • Data Source
      KAKENHI-PROJECT-15K14994
  • [Presentation] Receptor-type protein tyrosine phosphatase PTPRK attenuates CD133-mediated tumorigenesis of colon cancer cells through the down-regulation of pro-oncogenic CD133-PI3K-AKT pathway.2015

    • Author(s)
      早田浩明(7人中3番目)、下里修(7人中2番目)
    • Organizer
      日本分子生物学会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2015-12-01
    • Data Source
      KAKENHI-PROJECT-26462033
  • [Presentation] 膜結合型チロシン脱リン酸化酵素PTPRKによるチロシン脱リン酸化はがん幹細胞マーカーCD133のAKT/b-catenin経路を介した発がん機構を負に制御する2013

    • Author(s)
      藁谷美雪、下里 修、早田浩明、(他3名)、上條岳彦
    • Organizer
      第36回分子生物学会
    • Place of Presentation
      神戸国際会議場
    • Data Source
      KAKENHI-PROJECT-24590496
  • [Presentation] 膜結合型チロシン脱リン酸化酵素PTPRKによるチロシン脱リン酸化はがん幹細胞マーカーCD133の機構を負に制御する2013

    • Author(s)
      下里 修, 早田 浩明, (他4名)
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Data Source
      KAKENHI-PROJECT-23591978
  • [Presentation] Functional p53 inactivation in neuroblastoma: novel 1p tumor suppressor DMAP1 regulates MYCN/ATM/p53 pathway2013

    • Author(s)
      Y Yamaguchi、(他1名)、下里 修、(他2名)、T Kamijo
    • Organizer
      第6回p63/p73国際シンポジウム
    • Place of Presentation
      かずさアカデミアパーク
    • Data Source
      KAKENHI-PROJECT-24590496
  • [Presentation] 膜結合型チロシン脱リン酸化酵素PTPRKによるチロシン脱リン酸化はがん幹細胞マーカーCD133の機能を負に制御する2013

    • Author(s)
      下里修、早田浩明(他4名)
    • Organizer
      第72回日本癌学会学術集会
    • Place of Presentation
      パシフィコ横浜
    • Data Source
      KAKENHI-PROJECT-23591978
  • [Presentation] 大腸がん由来spheroid細胞はエピゲノム的制御によるABCB1遺伝子の発現上昇によって多剤耐性を獲得する2013

    • Author(s)
      上原 悠, 下里 修, 藁谷 美雪, 早田 浩明,(他2名)、上條 岳彦
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Data Source
      KAKENHI-PROJECT-24590496
  • [Presentation] Sphere formation produces multi-drug resistancce in human colon cancer cells via histone modification of ABCB1 promoter.2012

    • Author(s)
      下里 修、(他4名)、上條 岳彦
    • Organizer
      第71回日本癌学会学術集会
    • Place of Presentation
      ロイトン札幌、札幌芸文館、札幌市教育文化会館
    • Data Source
      KAKENHI-PROJECT-24590496
  • [Presentation] Tumor sphere specific CD133 regulation in neuroblastoma2011

    • Author(s)
      竹信尚典、下里修, 他5名
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2011-10-03
    • Data Source
      KAKENHI-PROJECT-21790397
  • [Presentation] CD133 plays roles in keeping the undifferentiated status of human colon cancer cells via PI3K/AKT activation.2011

    • Author(s)
      下里 修(他5名)
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場
    • Data Source
      KAKENHI-PROJECT-23591978
  • [Presentation] CD133plays roles in keeping the undifferentiated status of human colon cancer cells via PI3K/AKT activation2011

    • Author(s)
      下里修(他5名)
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2011-10-03
    • Data Source
      KAKENHI-PROJECT-21790397
  • [Presentation] Acquired multi-drug resistance in human colon cancer cells by sphere Formation.2011

    • Author(s)
      中島久美子、下里 修(他4名)
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場
    • Data Source
      KAKENHI-PROJECT-23591978
  • [Presentation] CD133 plays roles in keeping the undifferentiated status of human colon cancer cells via PI3K/AKT activation2011

    • Author(s)
      下里修, 他5名
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2011-10-03
    • Data Source
      KAKENHI-PROJECT-21790397
  • [Presentation] Tumor sphere specific CD133 regulation in neuroblastoma.2011

    • Author(s)
      竹信尚典、下里 修(他5名)
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場
    • Data Source
      KAKENHI-PROJECT-23591978
  • [Presentation] CD133 plays roles in keeping the undifferentiated status of human colon cancer cells via PI3K/AKT activation2011

    • Author(s)
      下里修(他5名)
    • Organizer
      第70回日本癌学会学術集会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2011-10-03
    • Data Source
      KAKENHI-PROJECT-23591978
  • [Presentation] Acquired multi-drug resistance in human colon cancer cells by sphere Formation2011

    • Author(s)
      中島久美子、下里修, 他4名
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2011-10-03
    • Data Source
      KAKENHI-PROJECT-21790397
  • [Presentation] GATA-6 transactivates a novel promoter for stem cell marker CD133 gene in human colorectal cancer cells.2010

    • Author(s)
      下里修, (他5名)
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2010-09-23
    • Data Source
      KAKENHI-PROJECT-21790397
  • [Presentation] CD 133 regulates neuroblastoma stemness via p38MAPK and PI3K/Akt activation.2010

    • Author(s)
      竹信尚典、下里修, (他5名)
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2010-09-23
    • Data Source
      KAKENHI-PROJECT-21790397
  • [Presentation] GATA-6transactivates a novel promoter for stem cell marker CD133gene in human colorectal cancer cells2010

    • Author(s)
      下里修(他5名)
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2010-09-23
    • Data Source
      KAKENHI-PROJECT-21790397
  • [Presentation] 幹細胞マーカーCDI33分子はβ-cateninの制御を通じて大腸がん細胞の腫瘍形成を亢進する2009

    • Author(s)
      下里修
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      神奈川県横浜市パシフィコ横浜
    • Year and Date
      2009-10-01
    • Data Source
      KAKENHI-PROJECT-21790397
  • [Presentation] 幹細胞マーカーCD133分子はβ-cateninの制御を通じて大腸がん細胞の腫瘍形成を亢進する2009

    • Author(s)
      下里修(他5名)
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      神奈川県横浜市パシフィコ横浜
    • Year and Date
      2009-10-01
    • Data Source
      KAKENHI-PROJECT-21790397
  • [Presentation] 神経芽腫細胞における造腫瘍能を担う幹細胞マーカーCD133分子の機能ドメインの解析2008

    • Author(s)
      下里 修
    • Organizer
      第24回日小児がん学会学術総会
    • Place of Presentation
      千葉県千葉市幕張メッセ
    • Year and Date
      2008-11-14
    • Data Source
      KAKENHI-PROJECT-19790300
  • [Presentation] 大腸がん細胞株の分化誘導とがん形成における幹細胞マーカーCD133分子の機能解析2008

    • Author(s)
      下里 修
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      愛知県名古屋市名古屋国際会議場
    • Year and Date
      2008-10-29
    • Data Source
      KAKENHI-PROJECT-19790300
  • [Presentation] 神経芽腫細胞における造腫瘍能を担う幹細胞マーカーCD133分子の機能ドメインの解析2008

    • Author(s)
      下里修(6名中1番)
    • Organizer
      第24回日小児がん学会学術総会
    • Place of Presentation
      千葉県千葉市・幕張メッセ
    • Year and Date
      2008-11-14
    • Data Source
      KAKENHI-PROJECT-19790300
  • [Presentation] 大腸がん細胞株の分化誘導とがん形成における幹細胞マーカーCD133分子の機能解析2008

    • Author(s)
      下里修(6名中1番)
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      愛知県名古屋市・名古屋国際会議場
    • Year and Date
      2008-10-29
    • Data Source
      KAKENHI-PROJECT-19790300
  • [Presentation] Antibody against cancer stem cell marker CD133 down-regulates cell cycle progression in colon cancer cells2007

    • Author(s)
      下里修(4名中1番)
    • Organizer
      第66回日本癌学会学術総会
    • Place of Presentation
      神奈川県横浜市・パシフィコ横浜
    • Year and Date
      2007-10-03
    • Data Source
      KAKENHI-PROJECT-19790300
  • [Presentation] Antibody against cancer stem cell marker CD133 down-regulates cell cycle progression in colon cancer cells2007

    • Author(s)
      下里 修
    • Organizer
      第66回日本癌学会学術絵会
    • Place of Presentation
      神奈川県横浜市パシフィコ横浜
    • Year and Date
      2007-10-03
    • Data Source
      KAKENHI-PROJECT-19790300
  • [Presentation] 受容体型蛋白質チロシン脱リン酸化酵素PTPRKはCD133を脱リン酸化し、その下流に繋がるAKT経路の活性化を鎮静化する

    • Author(s)
      下里 修(7人中1番目)、早田浩明(7人中2番目)、上條岳彦(7人中5番目)
    • Organizer
      第73回日本癌学会学術集会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-09-25 – 2014-09-27
    • Data Source
      KAKENHI-PROJECT-26462033
  • [Presentation] ヒストン脱メチル化酵素JHDM1Bは大腸がんスフェア細胞のABCB1依存的な薬剤耐性獲得を阻害する

    • Author(s)
      下里 修(7人中2番目)、早田浩明(7人中3番目)、上條岳彦(7人中5番目)
    • Organizer
      第73回日本癌学会学術集会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-09-25 – 2014-09-27
    • Data Source
      KAKENHI-PROJECT-24590496
  • [Presentation] ヒストン脱メチル化酵素JHDM1Bは大腸がんスフェア細胞の多剤耐性獲得を阻害する

    • Author(s)
      下里 修(5人中2番目)、早田浩明(5人中3番目)
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-11-25 – 2014-11-27
    • Data Source
      KAKENHI-PROJECT-24590496
  • 1.  SOUDA Hiroaki (90261940)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 14 results
  • 2.  KAMIJO Takehiko (90262708)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 6 results
  • 3.  Nakamura Yohko (60260254)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 4.  巽 康年 (00450578)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  KAMOHARA hidenobu (90398222)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  KINOSHITA Yoshihiro (30195341)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  SAGISHIMA Katsuyuki (40336235)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  HIROSAKO Susumu (70432995)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  SAKAI Keisuke (10433038)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  ARAKAWA Hirofumi (70313088)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  Furihata Tomomi (80401008)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 12.  Nakamura Yuki (50869287)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 13.  尾崎 俊文 (40260252)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 9 results
  • 14.  井内 俊彦 (80370881)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  石毛 文隆 (60815801)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  北川 善康 (10838577)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 17.  中川原 章
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 18.  二階堂 敏雄
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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