KUNIMOTO Shohko 國本正子

… Alternative Names

國本正子クニモトショウコ

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Researcher Number	30350135
Other IDs
Affiliation (based on the past Project Information) *help	2015: 名古屋大学, 大学院医学系研究科, 特任助教 2012 – 2013: 名古屋大学, 医学(系)研究科(研究院), 特任助教 2010: 独立行政法人国立長寿医療研究センター, 加齢健康脳科学研究部, 流動研究員 2009: National Institute for Longevity Sciences,NCGG, 血管性認知症研究部, 流動研究員 2006 – 2007: 国立精神・神経センター, 神経研究所診断研究部, 研究員
Review Section/Research Field	Principal Investigator Psychiatric science / General internal medicine (including Psychosomatic medicine) / Neurology Except Principal Investigator Psychiatric science
Keywords	Principal Investigator 遺伝環境相互作用 / ストレス / DNAメチル化 / 産後うつ病 / 臨床精神分子遺伝学 / 血管性認知症モデル動物 / Notch3 / 動物モデル / CADASIL / 脳血管性認知症 / 脳神経疾患 / 痴呆 / 脳神経疾慮 … More Except Principal Investigator … More CNV / ゲノムコピー数多型 / ゲノムコピー数変異 / 双極性障害 Less

Identification of rare genetic variants associated with bipolar disorder and comprehensive analysis to elucidate its pathophysiology
- Principal Investigator
  
  OZAKI Norio
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Psychiatric science
- Research Institution
  Nagoya University
Genome cohort study of gene-environment interactions aim to identify biomarkers for peripartum depressionPrincipal Investigator
- Principal Investigator
  
  KUNIMOTO Shohko
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Psychiatric science
- Research Institution
  Nagoya University
Analyses on the acceleration mechanism of vascular dementia by chronic stressPrincipal Investigator
- Principal Investigator
  
  KUNIMOTO Shohko
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General internal medicine (including Psychosomatic medicine)
- Research Institution
  National Institute for Longevity Sciences,NCGG
社会性ストレスによる,辺縁系ニューロンの細胞死促進機構の解析Principal Investigator
- Principal Investigator
  
  國本正子
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurology
- Research Institution
  National Center of Neurology and Psychiatry

All 2014 2013 2012 2010 2009 2007 Other

All Journal Article Presentation Book Other

[Book] うつ病発症と遺伝子/環境相互作用2013
- Author(s)
  松本友里恵, 國本正子, 尾崎紀夫
- Publisher
  精神保健研究
- Data Source
  KAKENHI-PROJECT-24791210
[Book] 日本生物学的精神医学会誌2012
- Author(s)
  中村由嘉子, 國本正子, 尾崎紀夫
- Publisher
  妊産婦に生じるうつ病を対象としたゲノムコホート研究
- Data Source
  KAKENHI-PROJECT-24791210
[Book] 精神保健研究第26号（通巻59号）2012
- Author(s)
  松本友里恵, 國本正子, 尾崎紀夫
- Publisher
  うつ病発症と遺伝子/環境相互作用
- Data Source
  KAKENHI-PROJECT-24791210
[Book] 妊産婦に生じるうつ病を対象としたゲノムコホート研究, 日本生物学的精神医学会誌2012
- Author(s)
  中村由嘉子, 國本正子, 尾崎紀夫
- Data Source
  KAKENHI-PROJECT-24791210
[Journal Article] Factor structure of the Japanese version of the edinburgh postnatal depression scale in the postpartum period.2014
- Author(s)
  Kubota C, Okada T, Aleksic B, Nakamura Y, Kunimoto S, Morikawa M, Shiino T, Tamaji A, Ohoka H, Banno N, Morita T, Murase S, Goto S, Kanai A, Masuda T, Ando M, Ozaki N
- Journal Title
  
  PLoS One
  
  Volume: 9 Issue: 8 Pages: e103941-e103941
- DOI
  10.1371/journal.pone.0103941
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25253072
[Journal Article] Definition and refinement of the 7q36.3 duplication region associated with schizophrenia2013
- Author(s)
  Aleksic B, Kushima I, Ohye T, Ikeda M, Kunimoto S, Nakamura Y, Yoshimi A, Koide T, Iritani S, Kurahashi H, Iwata N, Ozaki N
- Journal Title
  
  Sci Rep
  
  Volume: 3 Issue: 1 Pages: 2587-2587
- DOI
  10.1038/srep02587
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591701, KAKENHI-PROJECT-24390085, KAKENHI-PROJECT-24791210, KAKENHI-PLANNED-25117010, KAKENHI-PROJECT-25253072, KAKENHI-PROJECT-25670516, KAKENHI-PROJECT-25860999
[Journal Article] Common variants in BCL9 gene and schizophrenia in a Japanese population: Association study, meta-analysis and cognitive function analysis2013
- Author(s)
  Tomoko Shiino, Takayoshi Koide, Itaru Kushima, Masashi Ikeda, Shohko Kunimoto, Yukako Nakamura, Akira Yoshimi, Branko Aleksic, Masahiro Banno, Tsutomu Kikuchi, Kunihiro Kohmura, Yasunori Adachi, Naoko Kawano, Takashi Okada, Toshiya Inada, Hiroshi Ujike, Tetsuya Iidaka, Michio Suzuki, Nakao Iwata, Norio Ozaki
- Journal Title
  
  J Med Biochem
  
  Volume: 32(4) Issue: 4 Pages: 351-357
- DOI
  10.2478/jomb-2013-0049
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791327, KAKENHI-PROJECT-24791210
[Journal Article] Common variants in bcl9 gene and schizophrenia in a japanese population: Association study, meta-analysis and cognitive function analysis.2013
- Author(s)
  Shiino T, Koide T, Kushima I, Ikeda M, Kunimoto S, Nakamura Y, Yoshimi A, Aleksic B, Banno M, Kikuchi T, Kohmura K, Adachi Y, Kawano N, Okada T, Inada T, Ujike H, Iidaka T, Suzuki M, Iwata N, Ozaki N
- Journal Title
  
  J Med Biochem
  
  Volume: 32 (4) Pages: 351-357
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25253072
[Journal Article] Differential effects of diazepam, tandospirone, and paroxetine on plasma brain-derived neurotrophic factor level under mental stress. Human Psychopharmacology2012
- Author(s)
  Tamaji A, Iwamoto K, Kawamura Y, Takahashi M, Ebe K, Kawano N, Kunimoto S, Aleksic B, Noda Y, Ozaki N
- Journal Title
  
  Clinical and Experimental
  
  Volume: 27 Issue: 3 Pages: 329-333
- DOI
  10.1002/hup.2220
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24791210
[Journal Article] Mutations in NOTCH3 cause the formation and retention of aggregates in the endoplasmic reticulum, leading to impaired cell proliferation.2010
- Author(s)
  Takahashi K, Adachi K, Yoshizaki K, Kunimoto S, Kalaria NR, Watanabe A
- Journal Title
  
  Human Molecular Genetics 19
  
  Pages: 79-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790639
[Journal Article] Mutations in NOTCH3 cause the formation and retention of aggregates in the endoplasmic reticulum, leading to impaired cell proliferation.2010
- Author(s)
  Takahashi K, Adachi K, Yoshizaki K, Kunimoto S, Kalaria N R, Watanabe A
- Journal Title
  
  Human Molecular Genetics 19
  
  Pages: 79-89
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790639
[Journal Article] Potent inhibitors of amyloid β fibrillization, 4,5-dianilinophthalimide and staurosporine aglycone, enhance degradation of preformed aggregates of mutant Notch3.2010
- Author(s)
  Takahashi K, Adachi K, Kunimoto S, Wakita H, Takeda K, Watanabe A
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 402 Pages: 54-58
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790639
[Journal Article] Chronic stress-mutated presenilin 1 gene interaction perturbs neurogenesis and accelerates neurodegeneration.2010
- Author(s)
  Kunimoto S, Nakamura S, Wada K, Inoue T
- Journal Title
  
  Experimental Neurology 221
  
  Pages: 175-185
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790639
[Journal Article] Potent inhibitors of amyloid ss fibrillization, 4,5-dianilinophthalimide and staurosporine aglycone, enhance degradation of preformed aggregates of mutant Notch3.2010
- Author(s)
  Takahashi K, Adachi K, Kunimoto S, Wakita H, Takeda K, Watanabe A
- Journal Title
  
  Biochemical and Biophysical Research Communications 402
  
  Pages: 54-58
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790639
[Journal Article] Chronic stress arrests the maturation of hippocampal neuronal progenitors in mice overexpressing an AD type presenilin 1(PS1)2007
- Author(s)
  Shohko Kunimoto
- Journal Title
  
  Neuroscience Research 58
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790607
[Presentation] 認知機能におけるグリア型グルタミン酸トランスポーター（GLAST）の役割. The role of glial glutamate transporter (GLAST) in cognitive functions in mice.2014
- Author(s)
  野田幸裕, 長谷川章, 谷口将之, 肥田裕丈, 毛利彰宏, 國本正子, 山田清文, 尾崎紀夫, 田中光一, 鍋島俊隆
- Organizer
  第87回日本薬理学会年会
- Place of Presentation
  東北大学百周年記念会館川内萩ホール、仙台国際センター（仙台市）
- Data Source
  KAKENHI-PROJECT-24791210
[Presentation] 認知機能におけるグリア型グルタミン酸トランスポーター(GLAST)の役割The role of glial glutamate transporter (GLAST) in cognitive functions in mice2014
- Author(s)
  野田幸裕, 長谷川章, 谷口将之, 肥田裕丈, 毛利彰宏, 國本正子, 山田清文, 尾崎紀夫, 田中光一, 鍋島俊隆
- Organizer
  第87回日本薬理学会年会
- Place of Presentation
  東北大学百周年記念会館川内萩ホール, 仙台国際センター(仙台市)
- Data Source
  KAKENHI-PROJECT-24791210
[Presentation] 変異型Notch3 ノックインマウスの生化学的解析2012
- Author(s)
  渡邉淳, 國本正子, 高橋慶吉
- Organizer
  第31回日本認知症学会学術集会
- Place of Presentation
  つくば国際会議場(つくば市)
- Data Source
  KAKENHI-PROJECT-24791210
[Presentation] 妊産婦の気分変動と血中ストレス関連物質との関連についての検討2012
- Author(s)
  玉地亜衣, 國本正子, 久保田智香, 水野妙子, 後藤節子, 村瀬聡美, 金井篤子, 尾崎紀夫
- Organizer
  第34回日本生物学的精神医学会
- Place of Presentation
  神戸国際会議場
- Data Source
  KAKENHI-PROJECT-24791210
[Presentation] 妊産婦の気分変動と血中ストレス関連物質との関連についての検討The examination of the relationships between postpartum blues and serum cortisol and cytokine levels2012
- Author(s)
  玉地亜衣, 國本正子, 久保田智香, 水野妙子, 後藤節子, 村瀬聡美, 金井篤子, 尾崎紀夫
- Organizer
  第34回日本生物学的精神医学会
- Place of Presentation
  神戸国際会議場(神戸市)
- Data Source
  KAKENHI-PROJECT-24791210
[Presentation] CADASIL モデルとしての変異NOTCH3ノックインマウスの作製と解析2010
- Author(s)
  國本正子、渡邉淳、足立香代、松崎三記子、武田和也、脇田英明、Rajech N Kalaria、丸山和佳子、高橋慶吉
- Organizer
  第33回日本神経科学大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-21790639
[Presentation] Proteomic analysis of the mutant Notch3-expressing cells and the microvessels of CADASIL brain2010
- Author(s)
  渡邊淳、國本正子、足立香代、武田和也、新飯田俊平、脇田英明、Rajech N.Kalaria、高橋慶吉
- Organizer
  ICAD 10 -Alzheimer's Association International Conference on Alzheimer's Disease 2010
- Place of Presentation
  ホノルル
- Data Source
  KAKENHI-PROJECT-21790639
[Presentation] CADASILモデルとしての変異NOTCH3ノックインマウスの作製と解析2010
- Author(s)
  國本正子
- Organizer
  第33回日本神経科学大会
- Place of Presentation
  神戸コンベンションセンター国際会議場
- Year and Date
  2010-09-04
- Data Source
  KAKENHI-PROJECT-21790639
[Presentation] 家族性脳血管性認知症(CADASIL)モデル動物の作製と病態解析2009
- Author(s)
  國本正子
- Organizer
  第28回日本認知症学会
- Place of Presentation
  東北大学百周年記念会館(宮城県)
- Year and Date
  2009-11-20
- Data Source
  KAKENHI-PROJECT-21790639
[Presentation] 変異Notch3による重合体の形成と細胞増殖の低下2009
- Author(s)
  渡邉淳、足立香代、國本正子、武田和也、脇田英明、高橋慶吉
- Organizer
  第28回日本認知症学会学術集会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-21790639
[Presentation] 家族性脳血管性認知症(CADASIL)モデル動物の作製と病態解析2009
- Author(s)
  國本正子、足立香代、吉崎嘉一、武田和也、脇田英明、高橋慶吉、渡邉淳
- Organizer
  第28回日本認知症学会学術集会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-21790639
[Presentation] AD変異型プレセニリン1過剰発現マウスの海馬神経前駆細胞は慢性ストレスにより分化抑制される2007
- Author(s)
  國本正子
- Organizer
  第30回日本神経科学大会
- Place of Presentation
  横浜
- Year and Date
  2007-09-11
- Data Source
  KAKENHI-PROJECT-18790607
[]

1. OZAKI Norio (40281480)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
2. IRITANI Syuji (60191904)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. IIDAKA Tetsuya (70324366)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. ALEKSIC Branko (60547511)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. KANBA Shigenobu (60312112)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 岡田俊

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 岩田仲生

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KUNIMOTO Shohko 國本 正子

國本 正子 クニモト ショウコ

Research Projects

Research Products

Co-Researchers

Identification of rare genetic variants associated with bipolar disorder and comprehensive analysis to elucidate its pathophysiology

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Genome cohort study of gene-environment interactions aim to identify biomarkers for peripartum depressionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analyses on the acceleration mechanism of vascular dementia by chronic stressPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

社会性ストレスによる,辺縁系ニューロンの細胞死促進機構の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] うつ病発症と遺伝子/環境相互作用2013

Author(s)

Publisher

Data Source

[Book] 日本生物学的精神医学会誌2012

Author(s)

Publisher

Data Source

[Book] 精神保健研究 第26号（通巻59号）2012

Author(s)

Publisher

Data Source

[Book] 妊産婦に生じるうつ病を対象としたゲノムコホート研究, 日本生物学的精神医学会誌2012

Author(s)

Data Source

[Journal Article] Factor structure of the Japanese version of the edinburgh postnatal depression scale in the postpartum period.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Definition and refinement of the 7q36.3 duplication region associated with schizophrenia2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Common variants in BCL9 gene and schizophrenia in a Japanese population: Association study, meta-analysis and cognitive function analysis2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Common variants in bcl9 gene and schizophrenia in a japanese population: Association study, meta-analysis and cognitive function analysis.2013

Author(s)

Journal Title

Data Source

[Journal Article] Differential effects of diazepam, tandospirone, and paroxetine on plasma brain-derived neurotrophic factor level under mental stress. Human Psychopharmacology2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mutations in NOTCH3 cause the formation and retention of aggregates in the endoplasmic reticulum, leading to impaired cell proliferation.2010

Author(s)

Journal Title

Data Source

[Journal Article] Mutations in NOTCH3 cause the formation and retention of aggregates in the endoplasmic reticulum, leading to impaired cell proliferation.2010

Author(s)

Journal Title

Data Source

[Journal Article] Potent inhibitors of amyloid β fibrillization, 4,5-dianilinophthalimide and staurosporine aglycone, enhance degradation of preformed aggregates of mutant Notch3.2010

Author(s)

Journal Title

Data Source

KUNIMOTO Shohko 國本正子

國本正子クニモトショウコ

[Book] 精神保健研究第26号（通巻59号）2012