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KUNIMOTO Shohko  國本 正子

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國本 正子  クニモト ショウコ

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Researcher Number 30350135
Other IDs
Affiliation (based on the past Project Information) *help 2015: 名古屋大学, 大学院医学系研究科, 特任助教
2012 – 2013: 名古屋大学, 医学(系)研究科(研究院), 特任助教
2010: 独立行政法人国立長寿医療研究センター, 加齢健康脳科学研究部, 流動研究員
2009: National Institute for Longevity Sciences,NCGG, 血管性認知症研究部, 流動研究員
2006 – 2007: 国立精神・神経センター, 神経研究所診断研究部, 研究員
Review Section/Research Field
Principal Investigator
Psychiatric science / General internal medicine (including Psychosomatic medicine) / Neurology
Except Principal Investigator
Psychiatric science
Keywords
Principal Investigator
遺伝環境相互作用 / ストレス / DNAメチル化 / 産後うつ病 / 臨床精神分子遺伝学 / 血管性認知症モデル動物 / Notch3 / 動物モデル / CADASIL / 脳血管性認知症 / 脳神経疾患 / 痴呆 / 脳神経疾慮 … More
Except Principal Investigator
… More CNV / ゲノムコピー数多型 / ゲノムコピー数変異 / 双極性障害 Less
  • Research Projects

    (4 results)
  • Research Products

    (28 results)
  • Co-Researchers

    (7 People)
  •  Identification of rare genetic variants associated with bipolar disorder and comprehensive analysis to elucidate its pathophysiology

    • Principal Investigator
      OZAKI Norio
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Psychiatric science
    • Research Institution
      Nagoya University
  •  Genome cohort study of gene-environment interactions aim to identify biomarkers for peripartum depressionPrincipal Investigator

    • Principal Investigator
      KUNIMOTO Shohko
    • Project Period (FY)
      2012 – 2013
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Psychiatric science
    • Research Institution
      Nagoya University
  •  Analyses on the acceleration mechanism of vascular dementia by chronic stressPrincipal Investigator

    • Principal Investigator
      KUNIMOTO Shohko
    • Project Period (FY)
      2009 – 2010
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      General internal medicine (including Psychosomatic medicine)
    • Research Institution
      National Institute for Longevity Sciences,NCGG
  •  社会性ストレスによる,辺縁系ニューロンの細胞死促進機構の解析Principal Investigator

    • Principal Investigator
      國本 正子
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Neurology
    • Research Institution
      National Center of Neurology and Psychiatry

All 2014 2013 2012 2010 2009 2007 Other

All Journal Article Presentation Book Other

  • [Book] うつ病発症と遺伝子/環境相互作用2013

    • Author(s)
      松本友里恵, 國本正子, 尾崎紀夫
    • Publisher
      精神保健研究
    • Data Source
      KAKENHI-PROJECT-24791210
  • [Book] 日本生物学的精神医学会誌2012

    • Author(s)
      中村由嘉子, 國本正子, 尾崎紀夫
    • Publisher
      妊産婦に生じるうつ病を対象としたゲノムコホート研究
    • Data Source
      KAKENHI-PROJECT-24791210
  • [Book] 精神保健研究 第26号(通巻59号)2012

    • Author(s)
      松本友里恵, 國本正子, 尾崎紀夫
    • Publisher
      うつ病発症と遺伝子/環境相互作用
    • Data Source
      KAKENHI-PROJECT-24791210
  • [Book] 妊産婦に生じるうつ病を対象としたゲノムコホート研究, 日本生物学的精神医学会誌2012

    • Author(s)
      中村由嘉子, 國本正子, 尾崎紀夫
    • Data Source
      KAKENHI-PROJECT-24791210
  • [Journal Article] Factor structure of the Japanese version of the edinburgh postnatal depression scale in the postpartum period.2014

    • Author(s)
      Kubota C, Okada T, Aleksic B, Nakamura Y, Kunimoto S, Morikawa M, Shiino T, Tamaji A, Ohoka H, Banno N, Morita T, Murase S, Goto S, Kanai A, Masuda T, Ando M, Ozaki N
    • Journal Title

      PLoS One

      Volume: 9 Issue: 8 Pages: e103941-e103941

    • DOI

      10.1371/journal.pone.0103941

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25253072
  • [Journal Article] Definition and refinement of the 7q36.3 duplication region associated with schizophrenia2013

    • Author(s)
      Aleksic B, Kushima I, Ohye T, Ikeda M, Kunimoto S, Nakamura Y, Yoshimi A, Koide T, Iritani S, Kurahashi H, Iwata N, Ozaki N
    • Journal Title

      Sci Rep

      Volume: 3 Issue: 1 Pages: 2587-2587

    • DOI

      10.1038/srep02587

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591701, KAKENHI-PROJECT-24390085, KAKENHI-PROJECT-24791210, KAKENHI-PLANNED-25117010, KAKENHI-PROJECT-25253072, KAKENHI-PROJECT-25670516, KAKENHI-PROJECT-25860999
  • [Journal Article] Common variants in BCL9 gene and schizophrenia in a Japanese population: Association study, meta-analysis and cognitive function analysis2013

    • Author(s)
      Tomoko Shiino, Takayoshi Koide, Itaru Kushima, Masashi Ikeda, Shohko Kunimoto, Yukako Nakamura, Akira Yoshimi, Branko Aleksic, Masahiro Banno, Tsutomu Kikuchi, Kunihiro Kohmura, Yasunori Adachi, Naoko Kawano, Takashi Okada, Toshiya Inada, Hiroshi Ujike, Tetsuya Iidaka, Michio Suzuki, Nakao Iwata, Norio Ozaki
    • Journal Title

      J Med Biochem

      Volume: 32(4) Issue: 4 Pages: 351-357

    • DOI

      10.2478/jomb-2013-0049

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23791327, KAKENHI-PROJECT-24791210
  • [Journal Article] Common variants in bcl9 gene and schizophrenia in a japanese population: Association study, meta-analysis and cognitive function analysis.2013

    • Author(s)
      Shiino T, Koide T, Kushima I, Ikeda M, Kunimoto S, Nakamura Y, Yoshimi A, Aleksic B, Banno M, Kikuchi T, Kohmura K, Adachi Y, Kawano N, Okada T, Inada T, Ujike H, Iidaka T, Suzuki M, Iwata N, Ozaki N
    • Journal Title

      J Med Biochem

      Volume: 32 (4) Pages: 351-357

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25253072
  • [Journal Article] Differential effects of diazepam, tandospirone, and paroxetine on plasma brain-derived neurotrophic factor level under mental stress. Human Psychopharmacology2012

    • Author(s)
      Tamaji A, Iwamoto K, Kawamura Y, Takahashi M, Ebe K, Kawano N, Kunimoto S, Aleksic B, Noda Y, Ozaki N
    • Journal Title

      Clinical and Experimental

      Volume: 27 Issue: 3 Pages: 329-333

    • DOI

      10.1002/hup.2220

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24791210
  • [Journal Article] Mutations in NOTCH3 cause the formation and retention of aggregates in the endoplasmic reticulum, leading to impaired cell proliferation.2010

    • Author(s)
      Takahashi K, Adachi K, Yoshizaki K, Kunimoto S, Kalaria NR, Watanabe A
    • Journal Title

      Human Molecular Genetics 19

      Pages: 79-8

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790639
  • [Journal Article] Mutations in NOTCH3 cause the formation and retention of aggregates in the endoplasmic reticulum, leading to impaired cell proliferation.2010

    • Author(s)
      Takahashi K, Adachi K, Yoshizaki K, Kunimoto S, Kalaria N R, Watanabe A
    • Journal Title

      Human Molecular Genetics 19

      Pages: 79-89

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790639
  • [Journal Article] Potent inhibitors of amyloid β fibrillization, 4,5-dianilinophthalimide and staurosporine aglycone, enhance degradation of preformed aggregates of mutant Notch3.2010

    • Author(s)
      Takahashi K, Adachi K, Kunimoto S, Wakita H, Takeda K, Watanabe A
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 402 Pages: 54-58

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790639
  • [Journal Article] Chronic stress-mutated presenilin 1 gene interaction perturbs neurogenesis and accelerates neurodegeneration.2010

    • Author(s)
      Kunimoto S, Nakamura S, Wada K, Inoue T
    • Journal Title

      Experimental Neurology 221

      Pages: 175-185

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790639
  • [Journal Article] Potent inhibitors of amyloid ss fibrillization, 4,5-dianilinophthalimide and staurosporine aglycone, enhance degradation of preformed aggregates of mutant Notch3.2010

    • Author(s)
      Takahashi K, Adachi K, Kunimoto S, Wakita H, Takeda K, Watanabe A
    • Journal Title

      Biochemical and Biophysical Research Communications 402

      Pages: 54-58

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790639
  • [Journal Article] Chronic stress arrests the maturation of hippocampal neuronal progenitors in mice overexpressing an AD type presenilin 1(PS1)2007

    • Author(s)
      Shohko Kunimoto
    • Journal Title

      Neuroscience Research 58

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18790607
  • [Presentation] 認知機能におけるグリア型グルタミン酸トランスポーター(GLAST)の役割. The role of glial glutamate transporter (GLAST) in cognitive functions in mice.2014

    • Author(s)
      野田幸裕, 長谷川章, 谷口将之, 肥田裕丈, 毛利彰宏, 國本正子, 山田清文, 尾崎紀夫, 田中光一, 鍋島俊隆
    • Organizer
      第87回日本薬理学会年会
    • Place of Presentation
      東北大学百周年記念会館川内萩ホール、仙台国際センター(仙台市)
    • Data Source
      KAKENHI-PROJECT-24791210
  • [Presentation] 認知機能におけるグリア型グルタミン酸トランスポーター(GLAST)の役割The role of glial glutamate transporter (GLAST) in cognitive functions in mice2014

    • Author(s)
      野田幸裕, 長谷川章, 谷口将之, 肥田裕丈, 毛利彰宏, 國本正子, 山田清文, 尾崎紀夫, 田中光一, 鍋島俊隆
    • Organizer
      第87回日本薬理学会年会
    • Place of Presentation
      東北大学百周年記念会館川内萩ホール, 仙台国際センター(仙台市)
    • Data Source
      KAKENHI-PROJECT-24791210
  • [Presentation] 変異型Notch3 ノックインマウスの生化学的解析2012

    • Author(s)
      渡邉淳, 國本正子, 高橋慶吉
    • Organizer
      第31回 日本認知症学会学術集会
    • Place of Presentation
      つくば国際会議場(つくば市)
    • Data Source
      KAKENHI-PROJECT-24791210
  • [Presentation] 妊産婦の気分変動と血中ストレス関連物質との関連についての検討2012

    • Author(s)
      玉地亜衣, 國本正子, 久保田智香, 水野妙子, 後藤節子, 村瀬聡美, 金井篤子, 尾崎紀夫
    • Organizer
      第34回日本生物学的精神医学会
    • Place of Presentation
      神戸国際会議場
    • Data Source
      KAKENHI-PROJECT-24791210
  • [Presentation] 妊産婦の気分変動と血中ストレス関連物質との関連についての検討The examination of the relationships between postpartum blues and serum cortisol and cytokine levels2012

    • Author(s)
      玉地亜衣, 國本正子, 久保田智香, 水野妙子, 後藤節子, 村瀬聡美, 金井篤子, 尾崎紀夫
    • Organizer
      第34回日本生物学的精神医学会
    • Place of Presentation
      神戸国際会議場(神戸市)
    • Data Source
      KAKENHI-PROJECT-24791210
  • [Presentation] CADASIL モデルとしての変異NOTCH3ノックインマウスの作製と解析2010

    • Author(s)
      國本正子、渡邉淳、足立香代、松崎三記子、武田和也、脇田英明、Rajech N Kalaria、丸山和佳子、高橋慶吉
    • Organizer
      第33回日本神経科学大会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-21790639
  • [Presentation] Proteomic analysis of the mutant Notch3-expressing cells and the microvessels of CADASIL brain2010

    • Author(s)
      渡邊淳、國本正子、足立香代、武田和也、新飯田俊平、脇田英明、Rajech N.Kalaria、高橋慶吉
    • Organizer
      ICAD 10 -Alzheimer's Association International Conference on Alzheimer's Disease 2010
    • Place of Presentation
      ホノルル
    • Data Source
      KAKENHI-PROJECT-21790639
  • [Presentation] CADASILモデルとしての変異NOTCH3ノックインマウスの作製と解析2010

    • Author(s)
      國本正子
    • Organizer
      第33回日本神経科学大会
    • Place of Presentation
      神戸コンベンションセンター国際会議場
    • Year and Date
      2010-09-04
    • Data Source
      KAKENHI-PROJECT-21790639
  • [Presentation] 家族性脳血管性認知症(CADASIL)モデル動物の作製と病態解析2009

    • Author(s)
      國本正子
    • Organizer
      第28回日本認知症学会
    • Place of Presentation
      東北大学百周年記念会館(宮城県)
    • Year and Date
      2009-11-20
    • Data Source
      KAKENHI-PROJECT-21790639
  • [Presentation] 変異Notch3による重合体の形成と細胞増殖の低下2009

    • Author(s)
      渡邉淳、足立香代、國本正子、武田和也、脇田英明、高橋慶吉
    • Organizer
      第28回日本認知症学会学術集会
    • Place of Presentation
      仙台
    • Data Source
      KAKENHI-PROJECT-21790639
  • [Presentation] 家族性脳血管性認知症(CADASIL)モデル動物の作製と病態解析2009

    • Author(s)
      國本正子、足立香代、吉崎嘉一、武田和也、脇田英明、高橋慶吉、渡邉淳
    • Organizer
      第28回日本認知症学会学術集会
    • Place of Presentation
      仙台
    • Data Source
      KAKENHI-PROJECT-21790639
  • [Presentation] AD変異型プレセニリン1過剰発現マウスの海馬神経前駆細胞は慢性ストレスにより分化抑制される2007

    • Author(s)
      國本 正子
    • Organizer
      第30回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2007-09-11
    • Data Source
      KAKENHI-PROJECT-18790607
  • []

  • 1.  OZAKI Norio (40281480)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 2.  IRITANI Syuji (60191904)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 3.  IIDAKA Tetsuya (70324366)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 4.  ALEKSIC Branko (60547511)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 5.  KANBA Shigenobu (60312112)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  岡田 俊
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 7.  岩田 仲生
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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