TAKETANI Takeshi 竹谷健

Researcher Number	30359880
Other IDs
Affiliation (Current)	2025: 島根大学, 学術研究院医学・看護学系, 教授
Affiliation (based on the past Project Information) *help	2018 – 2024: 島根大学, 学術研究院医学・看護学系, 教授 2016 – 2017: 島根大学, 医学部, 教授 2007 – 2016: Shimane University, 医学部, 講師 2003 – 2006: 島根大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Pediatrics / Basic Section 52050:Embryonic medicine and pediatrics-related / Basic Section 52050:Embryonic medicine and pediatrics-related Except Principal Investigator Basic Section 52050:Embryonic medicine and pediatrics-related / Embryonic/Neonatal medicine
Keywords	Principal Investigator FLT3 / 白血病 / 低ホスファターゼ症 / 間葉系幹細胞 / WT1 / RAS / HOX / NUP98 / FLT3遺伝子 / 脂肪酸代謝異常症 … More / 低ホスファターぜ症 / ミトコドリア / 先天代謝異常症 / ミトコンドリア病 / メタボローム / stemness / メタボローム解析 / タウリン / ウイルス感染 / 小児白血病 / APOBEC3B / FLT3-ITD / HOXA9 / NRAS / NUP98-HOXA9 / KIT / MDS / AML / 急性骨髄性白血病 / Leukemia / 11q23 / MLL / MLL遺伝子 / 乳児白血病 / Rapamycin / HOX遺伝子 / NUP98遺伝子 … More Except Principal Investigator 再生医療 / 薬剤耐性機構 / 急性骨髄性白血病 / 疾患多様性 / タンデムマス法 / 有機酸血症 / アミノ酸血症 / ハイリスクスクリーニング / 遺伝疫学 / 疾患発見頻度 / 疾患頻度 / アジア諸国 / 対象疾患 / 国際比較 / 国際協力 / アジア / 疫学調査 / 障害予防 / 脂肪酸代謝異常症 / 有機酸代謝異常症 / タンデムマス / 新生児マススクリーニング / 間葉系幹細胞 / 低フォスファターゼ症 / 慢性呼吸器疾患 / 脳性麻痺 / 肝炎 / 血友病 / 免疫学 / 再生医学 / トランスレーショナルリサーチ / 移植・再生医療 / 新生児脳症 / 新生児 / 免疫療法 / 血友病B / 新生児慢性肺疾患 / 新生児脳性麻痺 / 間葉系細胞 / 臍帯 Less

Molecular Mechanism Responsible for the FLT3 Inhibitor-Dependent-Proliferation of Resistant FLT3/ITD+ cells
- Principal Investigator
  
  福田誠司
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Sugiyama Jogakuen University
ミトコンドリア病モデル動物に対する高純度間葉系幹細胞の治療効果の検証Principal Investigator
- Principal Investigator
  
  竹谷健
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for JSPS Fellows
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Shimane University
Highly Purified Mesenchymal Stem Cell Therapy for Neuropathy of Congenital Metabolic Disorders Involved on MitochondriaPrincipal Investigator
- Principal Investigator
  
  竹谷健
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Shimane University
Investigation of the diversity of metabolic pathways affecting stemness in mesenchymal stem cellsPrincipal Investigator
- Principal Investigator
  
  Taketani Takeshi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Shimane University
Study of diversity in organic and fatty acid disorders in Asia
- Principal Investigator
  
  Yamaguchi Seiji
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Shimane University
Pathogenesis of APOBEC3B in childhood leukemiaPrincipal Investigator
- Principal Investigator
  
  TAKETANI TAKESHI
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Shimane University
Development of therapeutic technology for hypophosphatasia using genetically corrected mesenchymal stem cells
- Principal Investigator
  
  Oda Yasuaki
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Embryonic/Neonatal medicine
- Research Institution
  Shimane University
New tissue-repair and immuno-regulatory therapy with umbilical cord-derived mesenchymal stromal cells
- Principal Investigator
  
  Nagamura-Inoue Tokiko
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Embryonic/Neonatal medicine
- Research Institution
  The University of Tokyo
Leukemogenesis between NUP98-HOX fusion genes and concomitant mutationsPrincipal Investigator
- Principal Investigator
  
  TAKETANI Takeshi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Shimane University
Investigation of pathogenesis of leukemia with NUP98-HOX fusion genePrincipal Investigator
- Principal Investigator
  
  TAKETANI Takeshi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pediatrics
- Research Institution
  Shimane University
Efficacy of Rapamycin in leukemia with chromosomal 11q23 translocationPrincipal Investigator
- Principal Investigator
  
  TAKETANI Takeshi
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pediatrics
- Research Institution
  Shimane University
11p15転座型白血病のNUP98遺伝子の相手遺伝子の単離とその機能解析Principal Investigator
- Principal Investigator
  
  竹谷健
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pediatrics
- Research Institution
  Shimane University
  Shimane Medical University

[Journal Article] MELAS-Derived Neurons Functionally Improve by Mitochondrial Transfer from Highly Purified Mesenchymal Stem Cells (REC)2023
- Author(s)
  Liu Lu、Yang Jiahao、Otani Yoshinori、Shiga Takahiro、Yamaguchi Akihiro、Oda Yasuaki、Hattori Miho、Goto Tsukimi、Ishibashi Shuichi、Kawashima-Sonoyama Yuki、Ishihara Takaya、Matsuzaki Yumi、Akamatsu Wado、Fujitani Masashi、Taketani Takeshi
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 24 Issue: 24 Pages: 17186-17186
- DOI
  10.3390/ijms242417186
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K07267, KAKENHI-PROJECT-23K07290, KAKENHI-PROJECT-21K06066, KAKENHI-PROJECT-22KJ2745, KAKENHI-PROJECT-21H02814, KAKENHI-PROJECT-23K27567
[Journal Article] A Simple Flow Injection Analysis-Tandem Mass Spectrometry Method to Reduce False Positives of C5-Acylcarnitines Due to Pivaloylcarnitine Using Reference Ions2022
- Author(s)
  Takanari Hattori, Yoshitomo Notsu, Misa Tanaka, Miki Matsui, Tetsuo Iida, Jun Watanabe, Yoshimitsu Osawa, Seiji Yamaguchi, Shozo Yano, Takeshi Taketani, Hironori Kobayashi
- Journal Title
  
  Children
  
  Volume: 9 Issue: 5 Pages: 694-694
- DOI
  10.3390/children9050694
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08347
[Journal Article] Clinical and molecular investigation of 37 Japanese patients with multiple acyl-CoA dehydrogenase deficiency: p.Y507D in ETFDH, a common Japanese variant, causes a mortal phenotype2022
- Author(s)
  Yamada Kenji、Osawa Yoshimitsu、Kobayashi Hironori、Bo Ryosuke、Mushimoto Yuichi、Hasegawa Yuki、Yamaguchi Seiji、Taketani Takeshi
- Journal Title
  
  Molecular Genetics and Metabolism Reports
  
  Volume: 33 Pages: 100940-100940
- DOI
  10.1016/j.ymgmr.2022.100940
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08300, KAKENHI-PROJECT-19K08347
[Journal Article] The frequencies of very long-chain acyl-CoA dehydrogenase deficiency genetic variants in Japan have changed since the implementation of expanded newborn screening2022
- Author(s)
  Osawa Yoshimitsu、Kobayashi Hironori、Tajima Go、Hara Keiichi、Yamada Kenji、Fukuda Seiji、Hasegawa Yuki、Aisaki Junko、Yuasa Miori、Hata Ikue、Okada Satoshi、Shigematsu Yosuke、Sasai Hideo、Fukao Toshiyuki、Takizawa Takumi、Yamaguchi Seiji、Taketani Takeshi
- Journal Title
  
  Molecular Genetics and Metabolism
  
  Volume: 136 Issue: 1 Pages: 74-79
- DOI
  10.1016/j.ymgme.2022.03.009
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07753, KAKENHI-PROJECT-19K08300, KAKENHI-PROJECT-22K07889, KAKENHI-PROJECT-19K08347
[Journal Article] Long-Term Neurological Outcomes of Adult Patients with Phenylketonuria before and after Newborn Screening in Japan2021
- Author(s)
  Yamada Kenji、Yamaguchi Seiji、Yokoyama Kazunori、Aoki Kikumaro、Taketani Takeshi
- Journal Title
  
  International Journal of Neonatal Screening
  
  Volume: 7 Issue: 2 Pages: 21-21
- DOI
  10.3390/ijns7020021
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08300, KAKENHI-PROJECT-19K08347
[Journal Article] Diagnosis of mucopolysaccharidoses and mucolipidosis as-saying multiplex enzymes and glycosaminoglycans2021
- Author(s)
  Arunkumar N, Vu DC, Khan S, Kobayashi H, Ngoc Can TB, Oguni T, Watanabe J, Tanaka M, Yamaguchi S, Taketani T, Ago Y, Ohnishi H, Saikia S, Álvarez JV, Tomatsu S.
- Journal Title
  
  Diagnostics (Basel)
  
  Volume: 11 Issue: 8 Pages: 1347-62
- DOI
  10.3390/diagnostics11081347
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08347
[Journal Article] Need for strict clinical management of patients with carnitine palmitoyltransferase II deficiency: Experience with two cases detected by expanded newborn screening2020
- Author(s)
  Bo Ryosuke、Musha Ikuma、Yamada Kenji、Kobayashi Hironori、Hasegawa Yuki、Awano Hiroyuki、Arao Masato、Kikuchi Toru、Taketani Takeshi、Ohtake Akira、Yamaguchi Seiji、Iijima Kazumoto
- Journal Title
  
  Molecular Genetics and Metabolism Reports
  
  Volume: 24 Pages: 100611-100611
- DOI
  10.1016/j.ymgmr.2020.100611
- NAID
  120006882474
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09969, KAKENHI-PROJECT-19K08300, KAKENHI-PROJECT-19K08347, KAKENHI-PROJECT-19K17298
[Journal Article] Long-Term Outcomes of Adult Patients with Homocystinuria before and after Newborn Screening2020
- Author(s)
  Yamada Kenji、Yokoyama Kazunori、Aoki Kikumaro、Taketani Takeshi、Yamaguchi Seiji
- Journal Title
  
  International Journal of Neonatal Screening
  
  Volume: 6 Issue: 3 Pages: 60-60
- DOI
  10.3390/ijns6030060
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08300, KAKENHI-PROJECT-19K08347
[Journal Article] Clinical course in a patient with myopathic VLCAD deficiency during pregnancy with an affected baby2019
- Author(s)
  Yamada Kenji、Matsubara Keiichi、Matsubara Yuko、Watanabe Asami、Kawakami Sanae、Ochi Fumihiro、Kuwabara Kozue、Mushimoto Yuichi、Kobayashi Hironori、Hasegawa Yuki、Fukuda Seiji、Yamaguchi Seiji、Taketani Takeshi
- Journal Title
  
  JIMD Reports
  
  Volume: 49 Issue: 1 Pages: 17-20
- DOI
  10.1002/jmd2.12061
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08300, KAKENHI-PROJECT-19K08347, KAKENHI-PROJECT-16K09969, KAKENHI-PROJECT-16K21179
[Journal Article] Single nucleotide polymorphisms of the DGKB and VCAM1 genes are associated with granulocyte colony stimulating factor-mediated peripheral blood stem cell mobilization.2017
- Author(s)
  Mishima S, Matsuda C, Ishihara T, Nagase M, Taketani T, Nagai A.
- Journal Title
  
  Transfus Apher Sci
  
  Volume: 56 Issue: 2 Pages: 154-159
- DOI
  10.1016/j.transci.2016.10.011
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K10027
[Journal Article] Internal tandem duplication of FLT3 deregulates proliferation2016
- Author(s)
  Tomohiro Hirade, Mariko Abe Chie Onishi, Takeshi Taketani, Seiji Yamaguchi, Seiji Fukuda
- Journal Title
  
  International Journal of Hematology
  
  Volume: 103 Issue: 1 Pages: 95-106
- DOI
  10.1007/s12185-015-1908-8
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461593, KAKENHI-PROJECT-15K19616, KAKENHI-PROJECT-16K10027
[Journal Article] Internal Tandem Duplication in FLT3 Attenuates Proliferation and Regulates Resistance to the FLT3 Inhibitor AC220 by Modulating p21Cdkn1a and Pbx1 in Hematopoietic Cells2016
- Author(s)
  Abe M, Pelus LM, Singh P, Hirade T, Onishi C, Purevsuren J, Taketani T, Yamaguchi S, Fukuda S
- Journal Title
  
  PLOS One
  
  Volume: 11 Issue: 7 Pages: 1-26
- DOI
  10.1371/journal.pone.0158290
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461593, KAKENHI-PROJECT-16K10027, KAKENHI-PROJECT-15K19616
[Journal Article] Ex Vivo Expanded Allogeneic Mesenchymal Stem Cells with Bone Marrow Transplantation Improved Osteogenesis in Infants with Severe Hypophosphatasia2015
- Author(s)
  Taketani T, Oyama C, Mihara A, Tanabe Y, Abe M, Hirade T, Yamamoto S, Bo R, Kanai R, Tadenuma T, Michibata Y, Yamamoto S, Hattori M, Katsube Y, Ohnishi H, Sasao M, Oda Y, Hattori K, Yuba S, Ohgushi H, Yamaguchi S
- Journal Title
  
  Cell Transplant.
  
  Volume: 24 Issue: 10 Pages: 1931-1943
- DOI
  10.3727/096368914x685410
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26293251
[Journal Article] Cytogenetics and clinical features of pediatric myelodysplastic syndrome in Japan.2014
- Author(s)
  Moriwaki K, Manabe A, Taketani T, Kikuchi A, Nakahata T, Hayashi Y
- Journal Title
  
  Int J Hematol.
  
  Volume: 100 Issue: 5 Pages: 478-484
- DOI
  10.1007/s12185-014-1674-z
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24591550, KAKENHI-PROJECT-25461611, KAKENHI-PROJECT-26461598, KAKENHI-PROJECT-26670498
[Journal Article] Ectopic Neuroblastoma in Monozygotic Twins With Different Ages of Onset : Possible Twin-to-Twin Metastasis In Utero With Distinct Genetic Alterations After Birth2014
- Author(s)
  Taketani T, Takita J, Ueyama J, Kanai R, Kumori K, Maruyama R, Hayashi K, Ogawa S, Fukuda S, Yamaguchi S
- Journal Title
  
  J Pediatr Hematol Oncol
  
  Volume: 36 Issue: 2 Pages: 166-168
- DOI
  10.1097/mph.0b013e318290c686
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21249085, KAKENHI-PROJECT-23390269, KAKENHI-PROJECT-24591550, KAKENHI-PROJECT-24659491, KAKENHI-PROJECT-26293242, KAKENHI-PROJECT-26670493
[Journal Article] Internal Tandem Duplication of Mutations in Flt3 Augment Chemotaxis by Blocking the Down-regulation of Rho-Associated Kinase via CXCL12/CXCR4 signaling axis.2014
- Author(s)
  Onishi C, Mori-Kimachi S, Hirade T, Abe M, Taketani T, Suzumiya J, Sugimoto T, Yamaguchi S, Kapur R, Fukuda S
- Journal Title
  
  J Biol Chem
  
  Volume: 289 Issue: 45 Pages: 31053-31065
- DOI
  10.1074/jbc.m114.568287
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24591550, KAKENHI-PROJECT-25461593
[Journal Article] Therapy-related Ph+ leukemia after both bone marrow and mesenchymal stem cell transplantation for hypophosphatasia.2013
- Author(s)
  Taketani T, Kanai R, Abe M, Mishima S, Tadokoro M, Katsube Y, Yuba S, Ogushi H, Fukuda S, Yamaguchi S.
- Journal Title
  
  Pediatr Int
  
  Volume: 55 Issue: 3
- DOI
  10.1111/ped.12012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591550
[Journal Article] 皮膚限局型未分化大細胞型リンパ腫の小児例2013
- Author(s)
  斎藤敦郎、竹谷健、金井理恵、金子栄、澄川靖之、三原綾、森田栄伸、山口清次
- Journal Title
  
  日本小児血液がん学会雑誌
  
  Volume: 50 Pages: 237-242
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591550
[Journal Article] Low-density lipoprotein as a biomarker for the mobilization of hematopoietic stem cells in peripheral blood.2013
- Author(s)
  Ishihara T, Mishima S, Kodama R, Yoshino I, Adachi E, Suyama T, Shibata H, Taketani T, Nagai A
- Journal Title
  
  Transfus Apher Sci
  
  Volume: 49 Issue: 3 Pages: 539-541
- DOI
  10.1016/j.transci.2013.07.033
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591550
[Journal Article] A Case With Sacrococcygeal Primitive Myxoid Mesenchymal Tumor of Infancy : A Case Report and Review of the Literature2013
- Author(s)
  Saito A, Taketani T, Kanai R, Kanagawa T, Kumori K, Yamamoto N, Ishikawa N, Takita J, Yamaguchi S
- Journal Title
  
  J Pediatr Hematol Oncol
  
  Volume: 35 Issue: 7 Pages: e280-e282
- DOI
  10.1097/mph.0b013e31829182bb
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249085, KAKENHI-PROJECT-23390269, KAKENHI-PROJECT-24591550, KAKENHI-PROJECT-24659491
[Journal Article] Childhood acute myeloid leukemia with bone marrow eosinophilia caused by t(16;21)(q24;q22)2012
- Author(s)
  Kawashima N, Shimada A, Taketani T, Hayashi Y, Yoshida N, Matsumoto K, Takahashi Y, Kojima S, Kato K
- Journal Title
  
  Int J Hematol
  
  Volume: 95 Issue: 5 Pages: 577-580
- DOI
  10.1007/s12185-012-1044-7
- NAID
  10030633418
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591171, KAKENHI-PROJECT-22659196, KAKENHI-PROJECT-23591536, KAKENHI-PROJECT-23591537, KAKENHI-PROJECT-23591560, KAKENHI-PROJECT-24390268, KAKENHI-PROJECT-24591550
[Journal Article] Survivin selectively modulates genes deregulated in human leukemia stem cells2011
- Author(s)
  Fukuda S, Abe M, Onishi C, Taketani T, Purevsuren J, Yamaguchi S, Conway EM, Pelus LM
- Journal Title
  
  Journal of Oncology
  
  Pages: 946936-946936
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790989
[Journal Article] High frequencies of simultaneous FLT3-ITD, WT1 and KIT mutations in hematological malignancies with NUP98-fusion genes.2010
- Author(s)
  Taketani T
- Journal Title
  
  Leukemia
  
  Volume: 24巻 Pages: 1975-1977
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790989
[Journal Article] High frequencies of simultaneous FLT3-ITD, WT1 and KIT mutations in hematological malignancies with NUP98-fusion genes2010
- Author(s)
  Taketani T, Taki T, Nakamura T, Kobayashi Y, Ito E, Fukuda S, Yamaguchi S, Hayashi Y
- Journal Title
  
  Leukemia
  
  Volume: 24 Pages: 1975-1977
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790989
[Journal Article] NUP98-NSD3 fusion gene in radiation-associated myelodysplastic syndrome with t(8;11)(p11;p15)and expression pattern of NSD family genes.2009
- Author(s)
  Taketani T
- Journal Title
  
  Cancer Genetics Cytogenetics 190
  
  Pages: 108-112
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790989
[Journal Article] Mutations of GATA1,FLT3,MLL-partial tandem duplication,NRAS,and RUNX1 genes are not found in a 7-year-old Down syndrome patient with acute myeloid leukemia (FAB-M2) having a good prognosis.2008
- Author(s)
  Kawamura M,Kaku H,Taketani T,Taki T,Shimada A,Hayashi Y
- Journal Title
  
  Cancer Genet Cytogenet 180
  
  Pages: 74-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790720
[Journal Article] Tandem duplications of MLL and FLT3 are correlated with poor prognoses in pediatric acute myeloid leukemia : a study of the Japanese childhood AML Cooperative Study Group2008
- Author(s)
  Shimada A,Taki T,Tabuchi K,Taketani T,Hanada R, Tawa A,Tsuchida M,Horibe K,Tsukimoto I,Hayashi Y
- Journal Title
  
  Pediatr Blood Cancer 50
  
  Pages: 264-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790720
[Journal Article] MNX1-ETV6 fusion gene in an acute megakaryoblastic leukemia and expression of the MNX1 gene in leukemia and normal B cell lines.2008
- Author(s)
  Taketani T,Taki T,Sako M,Ishii T,Yamaguchi S,Hayashi Y
- Journal Title
  
  Cancer Genet Cytogenet 186
  
  Pages: 115-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790720
[Journal Article] Induction of differentiation of myeloid leukemia cells in primary culture in response to lithocholic acid acetate,a bile acid derivative,and cooperative effects with another differentiation inducer,cotylenin A.2008
- Author(s)
  Horie A,Akimoto M,Tsumura H,Makishima M,Taketani T,Yamaguchi S,Honma Y
- Journal Title
  
  Leuk Res 32
  
  Pages: 1112-1123
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790720
[Journal Article] MNX1-ETV6 fusion gene in an acute megakaryoblastic leukemia and expression of the MNX1 gene in leukemia and normal B cell lines2008
- Author(s)
  Taketani T
- Journal Title
  
  Cancer Genetics Cytogenetics 186
  
  Pages: 115-119
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790720
[Journal Article] AML1 Mutation and FLT3-internal Tandem Duplication in Leukemia Transformed From Myelodysplastic Syndrome2007
- Author(s)
  Shimada A,Taketani T,Kikuchi A,Hanada R, Arakawa H,Kimura H,Chen Y,Hayashi Y
- Journal Title
  
  J Pediatr Hematol Oncol 29
  
  Pages: 666-667
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790720
[Journal Article] FLT3 mutations in the activation loop of tyrosine kinase domain are frequently found in infant ALL with MLL rearrangements and pediatric ALL with hyperdiploidy2004
- Author(s)
  Taketani T
- Journal Title
  
  Blood 103-3
  
  Pages: 1085-1088
- Data Source
  KAKENHI-PROJECT-15790529
[Journal Article] HLXB9-ETV6 fusion gene in an acute megakaryoblastic leukemia patient and expression of the HLXB9 gene in leukemia and normal B cell lines
- Author(s)
  Takeshi Taketani
- Journal Title
  
  Haematologia (発表予定)
- Data Source
  KAKENHI-PROJECT-18790720
[Patent] ミトコンドリア病治療用組成物2023
- Inventor(s)
  竹谷健、杨嘉豪、松崎有未、陶山隆史
- Industrial Property Rights Holder
  竹谷健、杨嘉豪、松崎有未、陶山隆史
- Industrial Property Rights Type
  特許
- Filing Date
  2023
- Overseas
- Data Source
  KAKENHI-PROJECT-23K27567
[Presentation] MELAS-derived neuron functionally improve by mitochondrial transfer from Rapidly Expanding Cell, REC2024
- Author(s)
  LU LIU, Jiahao Yang, Yoshinori Otani, Takahiro Shiga, Akihiro Yamaguchi, Yumi Matsuzaki, Wado Akamatsu, Masashi Fujitani, Takeshi Taketani
- Organizer
  第23回日本再生医療学会
- Data Source
  KAKENHI-PROJECT-23K27567
[Presentation] 東アジア諸国のタンデムマスによる新生児スクリーニング結果の比較2022
- Author(s)
  山口清次、山田健治, 長谷川有紀、小林　弘典, 但馬剛, 竹谷健
- Organizer
  第49回日本マススクリーニング学会
- Data Source
  KAKENHI-PROJECT-19K08347
[Presentation] 検量線を用いたアシルカルニチン分析法における血清・血漿検体のアシルカルニチンの安定性に関する検討2020
- Author(s)
  大澤好充、小林　弘典, 野津吉友, 山田健治, 長谷川有紀, 山口清次, 竹谷健
- Organizer
  第47回日本マススクリーニング学会
- Data Source
  KAKENHI-PROJECT-19K08347
[Presentation] アジア諸国のタンデムマスによる新生児スクリーニング結果の比較2020
- Author(s)
  山口清次、山田健治, 長谷川有紀、小林　弘典, 但馬剛, 竹谷健
- Organizer
  第47回日本マススクリーニング学会
- Data Source
  KAKENHI-PROJECT-19K08347
[Presentation] Diversity of disease spectrum of the MS/MS screening targets in Asia2019
- Author(s)
  8) Yamaguchi S, Shibata N, Hasegawa Y, Kobayashi H, Yamada K, Ohsawa Y, Fukuda S, Taketani
- Organizer
  第61回先天代謝異常学会アジアセッション
- Data Source
  KAKENHI-PROJECT-19K08347
[Presentation] 先天性遺伝性疾患に対する再生医療2016
- Author(s)
  竹谷健
- Organizer
  第68回中国四国小児科学会
- Place of Presentation
  香川
- Year and Date
  2016-10-29
- Data Source
  KAKENHI-PROJECT-26293251
[Presentation] 間葉系幹細胞を用いた新たな治療～白血病から遺伝子疾患まで～2016
- Author(s)
  竹谷健
- Organizer
  小児白血病カンファレンス
- Place of Presentation
  岡山
- Invited
- Data Source
  KAKENHI-PROJECT-26293251
[Presentation] 間葉系幹細胞を用いた先天性骨系統疾患に対する骨再生2016
- Author(s)
  竹谷健
- Organizer
  第35回日本運動器移植・再生医学研究会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-26293251
[Presentation] 間葉系幹細胞移植による骨再生2016
- Author(s)
  竹谷健、松崎有未、弓場俊輔、大串始
- Organizer
  第15回日本再生医療学会
- Place of Presentation
  大阪
- Year and Date
  2016-03-17
- Data Source
  KAKENHI-PROJECT-26293251
[Presentation] Allogeneic Mesenchymal Stem Cell and Bone Marrow Transplantation Improved Osteogenesis in Patients with severe Hypophosphatasia2015
- Author(s)
  Taketani T, Oyama C, Tanabe Y, Yamamoto K, Kanai R, Yamaguchi S, Hattori M, Oda Y, Yuba S, Ohgushi H.
- Organizer
  The 11th Asian Society for Pediatric Research
- Place of Presentation
  大阪
- Year and Date
  2015-04-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293251
[Presentation] 先天性骨代謝疾患に対する同種間葉系幹細胞を用いた骨再生治療．シンポジウム2「明るい未来にむけた先天代謝異常症の再生治療の可能性」2015
- Author(s)
  竹谷健、山口清次
- Organizer
  第57回日本先天代謝異常学会
- Place of Presentation
  大阪
- Year and Date
  2015-11-12
- Invited
- Data Source
  KAKENHI-PROJECT-26293251
[Presentation] Treatment approach for hypophosphatasia via genetically modified patient’s MSCs derived from iPS cells2015
- Author(s)
  Yasuaki Oda, Mika Tadokoro, Shunsuke Yuba, Hajime Ohgushi, Seiji Yamaguchi, and Takeshi Taketani
- Organizer
  第11回 ALPS研究会
- Place of Presentation
  日本女子大学（東京都文京区目白台2-8-1）
- Year and Date
  2015-07-18
- Data Source
  KAKENHI-PROJECT-15K21176
[Presentation] 骨髄性造血器腫瘍の遺伝子解析の検討2011
- Author(s)
  竹谷健、服部美保、日向瑞貴、安部真理子、大西千恵、福田誠司
- Organizer
  第42回島根造血器腫瘍研究会
- Place of Presentation
  ホテル武志山荘(島根県出雲市)
- Year and Date
  2011-07-29
- Data Source
  KAKENHI-PROJECT-21790989
[Presentation] The Concurrent Mutations in Hematological Malignancies with NUP98-Fusion Genes are Associated with Clinical Prognosis of the Patients2011
- Author(s)
  Taketani T
- Organizer
  53rd American Society of Hematology Annual Meeting
- Place of Presentation
  San Diego, USA
- Year and Date
  2011-12-10
- Data Source
  KAKENHI-PROJECT-21790989
[Presentation] The Concurrent Mutations in Hematological Malignancies with NUP98-Fusion Genes are Associated with Clinical Prognosis of the Patients2011
- Author(s)
  Takeshi Taketani, Tomohiko Taki, Miz uki Hyuga, Chie Onishi, Seiji Fukuda, Seiji Yamaguchi, Yasuhide Hayashi
- Organizer
  53rd American Society of Hematology Annual Meeting
- Place of Presentation
  San diego, USA
- Year and Date
  2011-12-10
- Data Source
  KAKENHI-PROJECT-21790989
[Presentation] 染色体11p15異常を有する造血器腫瘍における遺伝子変異と臨床像の関連2011
- Author(s)
  竹谷健、滝智彦、日向瑞貴、安部真理子、福田誠司、山口清次、林泰秀
- Organizer
  第53回日本小児血液・がん学会
- Place of Presentation
  ベイシア文化ホール(群馬県高崎市)
- Year and Date
  2011-11-25
- Data Source
  KAKENHI-PROJECT-21790989
[Presentation] 染色体11p15異常を有する造血器腫瘍における遺伝子変異と臨床像の関連2011
- Author(s)
  竹谷健
- Organizer
  第53回日本小児血液・がん学会
- Place of Presentation
  ベイシア文化ホール(群馬県前橋市)
- Year and Date
  2011-11-25
- Data Source
  KAKENHI-PROJECT-21790989
[Presentation] NUP98遺伝子再構成を有する小児造血器腫瘍に同定された遺伝子変異とその臨床的意義2009
- Author(s)
  竹谷健
- Organizer
  第51回日本小児血液学会
- Place of Presentation
  東京ベイホテル東急(千葉)
- Year and Date
  2009-11-28
- Data Source
  KAKENHI-PROJECT-21790989
[Presentation] Clinical significance of somatic mutations in hematological malignancies with NUP98-fusion genes2009
- Author(s)
  Takeshi Taketani, Tomohiko Taki, Seiji Fukuda, Seiji Yamaguchi, Yasuhide Hayashi
- Organizer
  The 71st Annual meeting of the Japanese society of Hematology
- Place of Presentation
  京都国際会館(京都市)
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PROJECT-21790989
[Presentation] Clinical significance of somatic mutations in hematological malignancies with NUP98-Lfusion genes.2009
- Author(s)
  Taketani T
- Organizer
  The 71st Annual meeting of the Japanese society of Hematology.
- Place of Presentation
  Kyoto International Conference Center(Kyoto)
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PROJECT-21790989
[Presentation] NUP98遺伝子再構成を有する小児造血器腫瘍に同定された遺伝子変異とその臨床的意義2009
- Author(s)
  竹谷健、滝智彦、山口清次、林泰秀
- Organizer
  NUP98遺伝子再構成を有する小児造血器腫瘍に同定された遺伝子変異とその臨床的意義
- Place of Presentation
  東京ベイホテル東急(千葉県浦安市)
- Year and Date
  2009-11-28
- Data Source
  KAKENHI-PROJECT-21790989
[Presentation] High frequencies of FLT3-ITD, WT1, and KIT, mutations in hematologic malignancies with NUP98-fusion genes2009
- Author(s)
  Takeshi Taketani, Tomohiko Taki, Mariko Abe, Chie Onishi, Seiji Fukuda, Seiji Yamaguchi, Yasuhide Hayashi
- Organizer
  51th American Society of Hematology
- Place of Presentation
  New Orleans, USA
- Year and Date
  2009-12-06
- Data Source
  KAKENHI-PROJECT-21790989
[Presentation] High frequencies of FLT3-ITD, WT1, and KIT, mutations in hematologic malignancies with NUP98-fusion genes.2009
- Author(s)
  Taketani T
- Organizer
  51th American Society of Hematology
- Place of Presentation
  New Orleans, USA
- Year and Date
  2009-12-06
- Data Source
  KAKENHI-PROJECT-21790989
[Presentation] Correlation of FLT3-ITD and KIT mutations with clinical features in myeloid malignancies with NUP98-HOX fusion genes2008
- Author(s)
  Taketani T
- Organizer
  50th American Society of Hematology
- Place of Presentation
  San Francisico, USA
- Data Source
  KAKENHI-PROJECT-18790720
[Presentation] Correlation of FLT3-ITD and KIT mutations with clinical features in myeloid malignancies with NUP98-HOX fusion genes2008
- Author(s)
  Takeshi Taketani,Tomohiko Taki,Seiji Fukuda,Seiji Yamaguchi Yasuhide Hayashi
- Organizer
  50th American Society of Hematology,San Francisico
- Place of Presentation
  USA
- Data Source
  KAKENHI-PROJECT-18790720
[Presentation] Flt3/ITD Enhances Hematopoietic Cell Migration towards Chemokine CCL2 Independent of Blocking the Negative Feedback Mechanism on Rho-Associated Kinase.
- Author(s)
  Seiji Fukuda, Chie Onishi, Tomohiro Hirade, Mariko Abe, Takeshi Taketani, Seiji Yamaguchi.
- Organizer
  56rd American Society of Hematology Annual Meeting
- Place of Presentation
  The Moscone Center (San Francisco, USA）
- Year and Date
  2014-12-06 – 2014-12-09
- Data Source
  KAKENHI-PROJECT-24591550
[Presentation] Myeloid Cells having NUP98-HOX Fusion Genes with Simultaneous FLT3, NRAS, or WT1 Mutations Confer Growth Advantage, Inhibits Differeniation/Apoptosis, and Augment Self-Renewal.
- Author(s)
  Takeshi Taketani, Miho Hattori, Mariko Abe, Tomohiro Hirade, Seiji Fukuda, Seiji Yamaguchi.
- Organizer
  56rd American Society of Hematology Annual Meeting
- Place of Presentation
  The Moscone Center (San Francisco, USA）
- Year and Date
  2014-12-06 – 2014-12-09
- Data Source
  KAKENHI-PROJECT-24591550
[Presentation] Flt3/ITD変異はケモカインCCL2に対する造血細胞遊走を亢進する
- Author(s)
  福田誠司、平出智裕、安部真理子、竹谷　健、山口清次．
- Organizer
  第56回日本小児血液がん学会
- Place of Presentation
  岡山コンベンションセンター（岡山市）
- Year and Date
  2014-11-28 – 2014-11-30
- Data Source
  KAKENHI-PROJECT-24591550
[Presentation] NUP98-HOX融合遺伝子と協調する遺伝子変異との白血病発症メカニズムの解析．
- Author(s)
  竹谷健、服部美保、安部真理子、平出智裕、福田誠司、山口清次．
- Organizer
  第56回日本小児血液がん学会
- Place of Presentation
  岡山コンベンションセンター（岡山市）
- Year and Date
  2014-11-28 – 2014-11-30
- Data Source
  KAKENHI-PROJECT-24591550

1. MATSUZAKI Yumi (50338183)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
2. Nagamura-Inoue Tokiko (70240736)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. HIROSE Jun (00456112)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. Oda Yasuaki (70602473)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. Yamaguchi Seiji (60144044)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
6. 竹谷英之 (90206996)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
7. 福田誠司 (30273147)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. 大谷嘉典 (30815973)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. 藤谷昌司 (40376372)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. 赤松和土 (60338184)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. 山田健治 (70624930)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
12. MUKAI Takeo

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. MORI Yuka

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. Hori Akiko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. MOCHIDA Miho

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. NAGASE Mayumi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. NAITOU Mayumi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. SUYAMA Takashi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. YANG JIAHAO

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. KOBAYASHI Hironori

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
21. 林泰秀

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 滝田順子

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

TAKETANI Takeshi 竹谷 健

Research Projects

Research Products

Co-Researchers

Molecular Mechanism Responsible for the FLT3 Inhibitor-Dependent-Proliferation of Resistant FLT3/ITD+ cells

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ミトコンドリア病モデル動物に対する高純度間葉系幹細胞の治療効果の検証Principal Investigator

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Highly Purified Mesenchymal Stem Cell Therapy for Neuropathy of Congenital Metabolic Disorders Involved on MitochondriaPrincipal Investigator

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Investigation of the diversity of metabolic pathways affecting stemness in mesenchymal stem cellsPrincipal Investigator

Principal Investigator

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Review Section

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Study of diversity in organic and fatty acid disorders in Asia

Principal Investigator

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Review Section

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Pathogenesis of APOBEC3B in childhood leukemiaPrincipal Investigator

Principal Investigator

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Development of therapeutic technology for hypophosphatasia using genetically corrected mesenchymal stem cells

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New tissue-repair and immuno-regulatory therapy with umbilical cord-derived mesenchymal stromal cells

Principal Investigator

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Leukemogenesis between NUP98-HOX fusion genes and concomitant mutationsPrincipal Investigator

Principal Investigator

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Investigation of pathogenesis of leukemia with NUP98-HOX fusion genePrincipal Investigator

Principal Investigator

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Efficacy of Rapamycin in leukemia with chromosomal 11q23 translocationPrincipal Investigator

Principal Investigator

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11p15転座型白血病のNUP98遺伝子の相手遺伝子の単離とその機能解析Principal Investigator

Principal Investigator

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Research Institution

[Journal Article] MELAS-Derived Neurons Functionally Improve by Mitochondrial Transfer from Highly Purified Mesenchymal Stem Cells (REC)2023

Author(s)

Journal Title

DOI

TAKETANI Takeshi 竹谷健