YUMOTO Fumiaki 湯本史明

… Alternative Names

湯本史明ユモトフミアキ

Less

Researcher Number	30360150
Other IDs	https://orcid.org/0000-0002-9592-397X
Affiliation (based on the past Project Information) *help	2013 – 2022: 大学共同利用機関法人高エネルギー加速器研究機構, 物質構造科学研究所, 特任准教授 2005 – 2006: 東京慈恵会医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Basic Section 37010:Bio-related chemistry / Bio-related chemistry / Biomolecular chemistry / Biophysics Except Principal Investigator Basic Section 37030:Chemical biology-related
Keywords	Principal Investigator X線小角散乱解析 / X線結晶構造解析 / LRH-1 / クライオ電子顕微鏡 / 核内受容体 / X線溶液散乱解析 / 結晶化 / クライオ電子顕微鏡解析 / 転写因子複合体 / リガンド結合領域 … More / NR5A2 / DNA2重鎖 / 転写因子-DNA複合体 / 転写因子-DNA相互作用 / 転写因子 / 分子認識 / NMR / 立体構造 / 茶由来カテキン / 多次元NMR / スキンドファイバー / Ca^<2+>感受性 / 心筋症 … More Except Principal Investigator HIV / リン脂質 / HIV-1 Gag MAドメイン / PI(4,5)P2 / 抗エイズ薬 / カルジオリピン / MAドメイン / HIV-1 Gag Less

Development of HIV drugs based on the binding of HIV-1Gag MA domain to cardiolipin
- Principal Investigator
  
  Anraku Kensaku
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37030:Chemical biology-related
- Research Institution
  Kumamoto Health Science University
Elucidation of the molecular mechanism in transcriptional regulatory complex of human LRH-1 by X-ray crystallography and Cryo-EMPrincipal Investigator
- Principal Investigator
  
  湯本史明
- Project Period (FY)
  2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37010:Bio-related chemistry
- Research Institution
  High Energy Accelerator Research Organization
Elucidation of the molecular mechanism in transcriptional regulation by nuclear receptor LRH-1Principal Investigator
- Principal Investigator
  
  Yumoto Fumiaki
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bio-related chemistry
- Research Institution
  High Energy Accelerator Research Organization
Analysis in molecular mechanism of transcriptional activation of LRH-1 by beta-cateninPrincipal Investigator
- Principal Investigator
  
  YUMOTO Fumiaki
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Biomolecular chemistry
- Research Institution
  High Energy Accelerator Research Organization
トロポニン遺伝子変異による機能不全の分子メカニズム解析Principal Investigator
- Principal Investigator
  
  湯本史明
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biophysics
- Research Institution
  Jikei University School of Medicine

All 2019 2018 2017 2014 2013 2007 2006 2005 Other

All Journal Article Presentation

[Journal Article] Structural and functional analysis of troponins from scallop striated and human cardiac muscles2007
- Author(s)
  Yumoto, F., Tanokura, M.
- Journal Title
  
  Advances in Experimental Medicine and Biology 592
  
  Pages: 163-173
- Data Source
  KAKENHI-PROJECT-17770132
[Journal Article] Structural and functional analysis of troponins from scallop striated and human cardiac muscles2007
- Author(s)
  Murakami, K., Yumoto, F., Ohki, S-Y., Yasunaga, T., Tanokura, M., Wakabayashi, T.
- Journal Title
  
  Advances in Experimental Medicine and Biology 592
  
  Pages: 71-86
- Data Source
  KAKENHI-PROJECT-17770132
[Journal Article] Infrared spectroscopic study on Ca^<2+> binding to Akazara scallop troponin C in comparison with peptide analogues of its Ca^<2+>-binding Site IV2006
- Author(s)
  Nara, M., Yumoto, F., Nagata, K., Tanokura, M., Kagi, H., Ojima, T., Nishita, K., Morii, H.
- Journal Title
  
  Vibrational Spectroscopy 42
  
  Pages: 188-191
- Data Source
  KAKENHI-PROJECT-17770132
[Journal Article] Fourier transform infrared spectroscopic study on the Ca^<2+>-bound coordination structures of synthetic peptide analogues of the calcium-binding site III of troponin C2006
- Author(s)
  Nara, M., Morii, H., Yumoto, F, Kagi, H., Tanokura, M.
- Journal Title
  
  Biopolymers 82・4
  
  Pages: 339-343
- Data Source
  KAKENHI-PROJECT-17770132
[Journal Article] Fourier transform infrared spectroscopic analysis of the intact zona pellucida of the mammalian egg : changes in the secondary structure of bovine zona pellucida proteins during fertilization.2006
- Author(s)
  Nara M, Yonezawa N, Shimada T, Takahashi K, Tanokura M, Yumoto F, Nakagawa H, Ohashi K, Hamano S, Nakano M.
- Journal Title
  
  Experimental Biology and Medicine 231・2
  
  Pages: 166-171
- Data Source
  KAKENHI-PROJECT-17770132
[Journal Article] Comparative studies on the functional roles of N- and C-terminal regions of molluskan and vertebrate troponin-I.2005
- Author(s)
  Tanaka H, Takeya Y, Doi T, Yumoto F, Tanokura M, Ohtsuki I, Nishita K, Ojima T.
- Journal Title
  
  FEBS Journal 272・17
  
  Pages: 4475-4486
- Data Source
  KAKENHI-PROJECT-17770132
[Journal Article] Drastic Ca^<2+> sensitization of myofilament associated with a small structural change in troponin I in inherited restrictive cardiomyopathy.2005
- Author(s)
  Yumoto F, Lu QW, Morimoto S, Tanaka H, Kono N, Nagata K, Ojima T, Takahashi-Yanaga F, Miwa Y, Sasaguri T, Nishita K, Tanokura M, Ohtsuki Y.
- Journal Title
  
  Biochemical and Biophysical Research Communications 338・3
  
  Pages: 1519-1526
- Data Source
  KAKENHI-PROJECT-17770132
[Journal Article] Structural basis for Ca^<2+>-regulated muscle relaxation at interaction sites of troponin with actin and tropomyosin.2005
- Author(s)
  Murakami K, Yumoto F, Ohki SY, Yasunaga T, Tanokura M, Wakabayashi T.
- Journal Title
  
  Journal of Molecular Biology 352・1
  
  Pages: 178-201
- Data Source
  KAKENHI-PROJECT-17770132
[Journal Article] Functional importance of Ca^<2+>-deficient N-terminal lobe of molluscan troponin C in troponin regulation2005
- Author(s)
  Doi T, Satoh A, Tanaka H, Inoue A, Yumoto F, Tanokura M, Ohtsuki I, Nishita K, Ojima T.
- Journal Title
  
  Archives of Biochemistry and Biophysics 436・1
  
  Pages: 83-90
- Data Source
  KAKENHI-PROJECT-17770132
[Presentation] カルジオリピンとHIV-1 Gag MAドメインとの結合解析と創薬への展開2019
- Author(s)
  坂本亜里紗、立石大、門出和精、古賀涼子、小祝孝太郎、湯本史明、田辺幹雄、千田俊哉、三隅将吾、大塚雅巳、藤田美歌子、安楽健作
- Organizer
  第37回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-19K05742
[Presentation] IP6によるHIV制御メカニズムの解明とその誘導体L-HIPPOを用いたHIV根治薬の開発2019
- Author(s)
  立石大、門出和精、安楽健作、古賀涼子、チッフチハリルイブラヒム、小祝孝太郎、湯本史明、田辺幹雄、千田俊哉、大塚雅巳、藤田美歌子
- Organizer
  第42回分子生物学会
- Data Source
  KAKENHI-PROJECT-19K05742
[Presentation] Design and synthesis of phospholipid derivatives exhiviting high-affinity binding for the HIV-1 MA domain2019
- Author(s)
  Kensaku Anraku, Hiroshi Tateishi, Kazuaki Monde, Ryota Fukuda, Ryoko Koga, Kotaro Koiwai, Fumiaki Yumoto, Toshiya Senda, Shogo Misumi, Masami Otsuka, Mikako Fujita
- Organizer
  Retroviruses (Cold Spring Harbor, USA)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K05742
[Presentation] 人工イノシトールリン脂質誘導体を用いた新規HIV-1根絶法の開発2019
- Author(s)
  立石大、門出和精、安楽健作、古賀涼子、チッフチハリルイブラヒム、小祝孝太郎、湯本史明、千田俊哉、大塚雅巳、藤田美歌子
- Organizer
  日本ケミカルバイオロジー学会　第14回年会
- Data Source
  KAKENHI-PROJECT-19K05742
[Presentation] 核内受容体 LRH-1複合体の相関構造解析2018
- Author(s)
  湯本史明、サブリンエリーナ、清水伸隆、加藤龍一、フレッテリックロバート、千田俊哉
- Organizer
  第31回放射光学会年会
- Data Source
  KAKENHI-PROJECT-15K05578
[Presentation] Structural Biology of the Nuclear Receptor Complexes in the NR5A subfamily2017
- Author(s)
  Fumiaki Yumoto
- Organizer
  2017年度生命科学系学会合同年会
- Data Source
  KAKENHI-PROJECT-15K05578
[Presentation] Hybrid Methods in the Structure of LRH-1-DNA-Coactivator Complex2017
- Author(s)
  Fumiaki Yumoto, Elena Sablin, Nobutaka Shimizu, Toshiya Senda, Robert Fletterick
- Organizer
  生理研研究会
- Data Source
  KAKENHI-PROJECT-15K05578
[Presentation] Linking Structure to Biological Function2014
- Author(s)
  Fumiaki Yumoto
- Organizer
  WAKATE INTERNATIONAL SYMPOSIUM　DISCOVERY OF MEDICAL SCIENCES - WISDoMS -
- Place of Presentation
  Univeristy of Tsukuba
- Year and Date
  2014-11-06
- Invited
- Data Source
  KAKENHI-PROJECT-25882050
[Presentation] LRH-1 の beta-catenin による転写活性化の構造基盤2013
- Author(s)
  湯本史明
- Organizer
  日本生物物理学会
- Place of Presentation
  京都国際会館
- Data Source
  KAKENHI-PROJECT-25882050
[Presentation] Structural basis of transcriptional regulation by liver receptor homogloue-1
- Author(s)
  Fumiaki Yumoto, Robert Fletterick
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  京都国際会館
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-25882050

1. Anraku Kensaku (80389543)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
2. 坂本亜里紗 (70792084)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. 田辺幹雄 (00716871)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results

YUMOTO Fumiaki 湯本 史明

湯本 史明 ユモト フミアキ

Research Projects

Research Products

Co-Researchers

Development of HIV drugs based on the binding of HIV-1Gag MA domain to cardiolipin

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the molecular mechanism in transcriptional regulatory complex of human LRH-1 by X-ray crystallography and Cryo-EMPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the molecular mechanism in transcriptional regulation by nuclear receptor LRH-1Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis in molecular mechanism of transcriptional activation of LRH-1 by beta-cateninPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

トロポニン遺伝子変異による機能不全の分子メカニズム解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Structural and functional analysis of troponins from scallop striated and human cardiac muscles2007

Author(s)

Journal Title

Data Source

[Journal Article] Structural and functional analysis of troponins from scallop striated and human cardiac muscles2007

Author(s)

Journal Title

Data Source

[Journal Article] Infrared spectroscopic study on Ca^<2+> binding to Akazara scallop troponin C in comparison with peptide analogues of its Ca^<2+>-binding Site IV2006

Author(s)

Journal Title

Data Source

[Journal Article] Fourier transform infrared spectroscopic study on the Ca^<2+>-bound coordination structures of synthetic peptide analogues of the calcium-binding site III of troponin C2006

Author(s)

Journal Title

Data Source

[Journal Article] Fourier transform infrared spectroscopic analysis of the intact zona pellucida of the mammalian egg : changes in the secondary structure of bovine zona pellucida proteins during fertilization.2006

Author(s)

Journal Title

Data Source

[Journal Article] Comparative studies on the functional roles of N- and C-terminal regions of molluskan and vertebrate troponin-I.2005

Author(s)

Journal Title

Data Source

[Journal Article] Drastic Ca^<2+> sensitization of myofilament associated with a small structural change in troponin I in inherited restrictive cardiomyopathy.2005

Author(s)

Journal Title

Data Source

[Journal Article] Structural basis for Ca^<2+>-regulated muscle relaxation at interaction sites of troponin with actin and tropomyosin.2005

Author(s)

Journal Title

Data Source

[Journal Article] Functional importance of Ca^<2+>-deficient N-terminal lobe of molluscan troponin C in troponin regulation2005

Author(s)

Journal Title

Data Source

[Presentation] カルジオリピンとHIV-1 Gag MAドメインとの結合解析と創薬への展開2019

Author(s)

Organizer

Data Source

[Presentation] IP6によるHIV制御メカニズムの解明とその誘導体L-HIPPOを用いたHIV根治薬の開発2019

Author(s)

Organizer

Data Source

[Presentation] Design and synthesis of phospholipid derivatives exhiviting high-affinity binding for the HIV-1 MA domain2019

YUMOTO Fumiaki 湯本史明

湯本史明ユモトフミアキ