Takashita Emi 高下恵美

… Alternative Names

高下恵美タカシタエミ

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Researcher Number	30361249
Other IDs	https://orcid.org/0000-0002-9064-4699
Affiliation (Current)	2025: 国立健康危機管理研究機構, 国立感染症研究所インフルエンザ研究センター, 主任研究員
Affiliation (based on the past Project Information) *help	2021 – 2023: 国立感染症研究所, インフルエンザ・呼吸器系ウイルス研究センター, 主任研究官 2018 – 2020: 国立感染症研究所, インフルエンザウイルス研究センター, 主任研究官 2016: 国立感染症研究所, インフルエンザウイルス研究センター, 主任研究官 2015: 国立感染症研究所, その他部局等, 研究員 2014: 国立感染症研究所, その他部局等, 主任研究官 2004 – 2006: 山形大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Basic Section 58020:Hygiene and public health-related: including laboratory approach / Hygiene and public health / Virology / Biological Sciences
Keywords	Principal Investigator インフルエンザウイルス / 薬剤耐性ウイルス / 抗インフルエンザ薬 / HA / 薬剤耐性 / インフルエンザ / 薬剤性ウイルス / ヘムアグルチニン / 糖鎖

Establishment of a detection system for antiviral-resistant influenza virusesPrincipal Investigator
- Principal Investigator
  
  Takashita Emi
- Project Period (FY)
  2018 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 58020:Hygiene and public health-related: including laboratory approach
- Research Institution
  National Institute of Infectious Diseases
Detection of antiviral-resistant influenza virusesPrincipal Investigator
- Principal Investigator
  
  Takashita Emi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hygiene and public health
- Research Institution
  National Institute of Infectious Diseases
インフルエンザウイルスのHA亜型とNA亜型の組み合わせは生存のための必要条件かPrincipal Investigator
- Principal Investigator
  
  高下恵美
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Virology
- Research Institution
  Yamagata University
インフルエンザウイルスにおけるHA蛋白への糖鎖付加による免疫回避機構の解明Principal Investigator
- Principal Investigator
  
  高下恵美
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Yamagata University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2006 Other

All Journal Article Presentation Book

[Book] インフルエンザ診療ガイド2016-172016
- Author(s)
  高下恵美.
- Total Pages
  4
- Publisher
  日本医事新報社
- Data Source
  KAKENHI-PROJECT-26460816
[Book] インフルエンザ診療ガイド2015-162015
- Author(s)
  高下恵美
- Total Pages
  4
- Publisher
  日本医事新報社
- Data Source
  KAKENHI-PROJECT-26460816
[Book] インフルエンザ診療ガイド2014-152014
- Author(s)
  高下恵美
- Total Pages
  4
- Publisher
  日本医事新報社
- Data Source
  KAKENHI-PROJECT-26460816
[Journal Article] Antiviral Susceptibilities of Distinct Lineages of Influenza C and D Viruses2023
- Author(s)
  Takashita Emi、Murakami Shin、Matsuzaki Yoko、Fujisaki Seiichiro、Morita Hiroko、Nagata Shiho、Katayama Misa、Mizuta Katsumi、Nishimura Hidekazu、Watanabe Shinji、Horimoto Taisuke、Hasegawa Hideki
- Journal Title
  
  Viruses
  
  Volume: 15 Issue: 1 Pages: 244-244
- DOI
  10.3390/v15010244
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K10036
[Journal Article] Assessment of the frequency of SARS-CoV-2 Omicron variant escape from RNA-dependent RNA polymerase inhibitors and 3C-like protease inhibitors2023
- Author(s)
  Takashita Emi、Fujisaki Seiichiro、Morita Hiroko、Nagata Shiho、Miura Hideka、Nagashima Mami、Watanabe Shinji、Takeda Makoto、Kawaoka Yoshihiro、Hasegawa Hideki
- Journal Title
  
  Antiviral Research
  
  Volume: 216 Pages: 105671-105671
- DOI
  10.1016/j.antiviral.2023.105671
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K10036
[Journal Article] A community cluster of influenza A(H3N2) virus infection with reduced susceptibility to baloxavir due to a PA E199G substitution in Japan, February to March 20232023
- Author(s)
  Takashita Emi、Fujisaki Seiichiro、Morita Hiroko、Nagata Shiho、Miura Hideka、Matsuura Yuki、Yamamoto Saya、Chiba Shoko、Inoue Yumiko、Minami Iori、Yoshikawa Sayaka、Yamazaki Seiko、Kishida Noriko、Nakamura Kazuya、Shirakura Masayuki、Watanabe Shinji、Hasegawa Hideki
- Journal Title
  
  Eurosurveillance
  
  Volume: 28 Issue: 39 Pages: 2300501-2300501
- DOI
  10.2807/1560-7917.es.2023.28.39.2300501
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K10036
[Journal Article] Clinical And Virologic Impacts of Respiratory Viral Co-infections in Children With Influenza2023
- Author(s)
  Sato Masatoki、Takashita Emi、Katayose Masahiko、Nemoto Kenji、Sakai Nobuko、Fujisaki Seiichiro、Hashimoto Koichi、Hosoya Mitsuaki
- Journal Title
  
  Pediatric Infectious Disease Journal
  
  Volume: Publish Ahead of Print Issue: 8 Pages: 0000-0000
- DOI
  10.1097/inf.0000000000003940
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08210, KAKENHI-PROJECT-18K10036
[Journal Article] Antiviral Susceptibilities of Avian Influenza A(H5), A(H7), and A(H9) Viruses Isolated in Japan2022
- Author(s)
  Takashita Emi、Morita Hiroko、Nagata Shiho、Shirakura Masayuki、Fujisaki Seiichiro、Miura Hideka、Takayama Ikuyo、Arita Tomoko、Suzuki Yasushi、Yamaoka Masaoki、Tanikawa Taichiro、Tsunekuni Ryota、Mine Junki、Sakuma Saki、Uchida Yuko、Shibata Akihiro、Iwanaka Mari、Kishida Noriko、Nakamura Kazuya et al.
- Journal Title
  
  Jpn J Infect Dis
  
  Volume: 75 Issue: 4 Pages: 398-402
- DOI
  10.7883/yoken.JJID.2021.751
- NAID
  130008136488
- ISSN
  1344-6304, 1884-2836
- Year and Date
  2022-07-31
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K10036
[Journal Article] Are twindemics occurring?2022
- Author(s)
  Takashita Emi、Watanabe Shinji、Hasegawa Hideki、Kawaoka Yoshihiro
- Journal Title
  
  Influenza and Other Respiratory Viruses
  
  Volume: 17 Issue: 1
- DOI
  10.1111/irv.13090
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K10036
[Journal Article] Assays for Determining the Sialidase Activity of Influenza Viruses and Monitoring Influenza Virus Susceptibility to Neuraminidase Inhibitors2022
- Author(s)
  Takashita Emi
- Journal Title
  
  Methods Mol Biol
  
  Volume: - Pages: 287-302
- DOI
  10.1007/978-1-0716-2635-1_19
- ISBN
  9781071626344, 9781071626351
- Data Source
  KAKENHI-PROJECT-18K10036
[Journal Article] Global update on the susceptibilities of human influenza viruses to neuraminidase inhibitors and the cap-dependent endonuclease inhibitor baloxavir, 2018?20202022
- Author(s)
  Govorkova EA, Takashita E, Daniels RS, Fujisaki S, Presser LD, Patel MC, Huang W, Lackenby A, Nguyen HT, Pereyaslov D, Rattigan A, Brown SK, Samaan M, Subbarao K, Wong S, Wang D, Webby RJ, Yen HL, Zhang W, Meijer A, Gubareva LV
- Journal Title
  
  Antiviral Research
  
  Volume: 200 Pages: 105281-105281
- DOI
  10.1016/j.antiviral.2022.105281
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K10036
[Journal Article] Detection of variants with reduced baloxavir marboxil and oseltamivir susceptibility in children with influenza A during the 2019-2020 influenza season2021
- Author(s)
  Sato Masatoki、Takashita Emi、Katayose Masahiko、Nemoto Kenji、Sakai Nobuko、Fujisaki Seiichiro、Hashimoto Koichi、Hosoya Mitsuaki
- Journal Title
  
  The Journal of Infectious Diseases
  
  Volume: － Pages: 1735-1741
- DOI
  10.1093/infdis/jiab196
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K10036, KAKENHI-PROJECT-20K08210
[Journal Article] Influenza polymerase inhibitor resistance: Assessment of the current state of the art - A report of the isirv Antiviral group2021
- Author(s)
  Ison Michael G.、Hayden Frederick G.、Hay Alan J.、Gubareva Larisa V.、Govorkova Elena A.、Takashita Emi、McKimm-Breschkin Jennifer L.
- Journal Title
  
  Antiviral Research
  
  Volume: 194 Pages: 105158-105158
- DOI
  10.1016/j.antiviral.2021.105158
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K10036
[Journal Article] In Vitro Characterization of Multidrug-Resistant Influenza A(H1N1)pdm09 Viruses Carrying a Dual Neuraminidase Mutation Isolated from Immunocompromised Patients2020
- Author(s)
  Takashita Emi、Fujisaki Seiichiro、Yokoyama Masaru、Shirakura Masayuki、Morita Hiroko、Nakamura Kazuya、Kishida Noriko、Kuwahara Tomoko、Sato Hironori、Doi Ikuko、Sato Yuji、Takao Shinichi、Shimazu Yukie、Shimomura Takeshi、Ito Takuo、Watanabe Shinji、Odagiri Takato et al.
- Journal Title
  
  Pathogens
  
  Volume: 9 Issue: 9 Pages: 725-725
- DOI
  10.3390/pathogens9090725
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K10036
[Journal Article] Detection of Variants With Reduced Baloxavir Marboxil Susceptibility After Treatment of Children With Influenza A During the 2018?2019 Influenza Season2020
- Author(s)
  Sato Masatoki、Takashita Emi、Katayose Masahiko、Nemoto Kenji、Sakai Nobuko、Hashimoto Koichi、Hosoya Mitsuaki
- Journal Title
  
  The Journal of Infectious Diseases
  
  Volume: － Issue: 1 Pages: 121-125
- DOI
  10.1093/infdis/jiaa061
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K10036, KAKENHI-PROJECT-20K08210
[Journal Article] Detection of a Peramivir-Resistant Influenza B/Yamagata-Lineage Virus Imported from Indonesia in Aichi, Japan, March 20192020
- Author(s)
  Takashita Emi、Yasui Yoshihiro、Nagata Shiho、Morita Hiroko、Fujisaki Seiichiro、Miura Hideka、Shirakura Masayuki、Kishida Noriko、Nakamura Kazuya、Kuwahara Tomoko、Sugawara Hiromi、Sato Aya、Akimoto Miki、Kaido Tatsuya、Watanabe Shinji、Hasegawa Hideki、The Influenza Virus Surveillance Group of Japan
- Journal Title
  
  Japanese Journal of Infectious Diseases
  
  Volume: 73 Issue: 5 Pages: 386-390
- DOI
  10.7883/yoken.jjid.2020.084
- NAID
  130007907185
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K10036
[Journal Article] Influenza Polymerase Inhibitors: Mechanisms of Action and Resistance2020
- Author(s)
  Takashita Emi
- Journal Title
  
  Cold Spring Harbor Perspectives in Medicine
  
  Volume: － Issue: 5 Pages: a038687-a038687
- DOI
  10.1101/cshperspect.a038687
- Open Access
- Data Source
  KAKENHI-PROJECT-18K10036
[Journal Article] グローバル視点からみるインフルエンザの動向について教えてください2020
- Author(s)
  高下恵美
- Journal Title
  
  up-to-date 子どもの感染症
  
  Volume: 8 Pages: 10-11
- Data Source
  KAKENHI-PROJECT-18K10036
[Journal Article] Rapid detection of an I38T amino acid substitution in influenza polymerase acidic subunit associated with reduced susceptibility to baloxavir marboxil2020
- Author(s)
  Nakauchi Mina、Takashita Emi、Fujisaki Seiichiro、Shirakura Masayuki、Ogawa Rie、Morita Hiroko、Miura Hideka、Saito Shinji、Watanabe Shinji、Odagiri Takato、Kageyama Tsutomu
- Journal Title
  
  Influenza and Other Respiratory Viruses
  
  Volume: － Issue: 4 Pages: 436-443
- DOI
  10.1111/irv.12728
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K10036
[Journal Article] バロキサビルマルボキシルは、NA阻害薬耐性株に対しても有効なのでしょうか2020
- Author(s)
  高下恵美
- Journal Title
  
  インフルエンザ～その他の呼吸器感染症
  
  Volume: 70 Pages: 42-42
- Data Source
  KAKENHI-PROJECT-18K10036
[Journal Article] Global update on the susceptibilities of human influenza viruses to neuraminidase inhibitors and the cap-dependent endonuclease inhibitor baloxavir, 2017?20182020
- Author(s)
  Takashita Emi、Daniels Rod S.、Fujisaki Seiichiro、Gregory Vicki、Gubareva Larisa V.、Huang Weiijuan、Hurt Aeron C.、Lackenby Angie、Nguyen Ha T.、Pereyaslov Dmitriy、Roe Merryn、Samaan Magdi、Subbarao Kanta、Tse Herman、Wang Dayan、Yen Hui-Ling、Zhang Wenqing、Meijer Adam
- Journal Title
  
  Antiviral Research
  
  Volume: 175 Pages: 104718-104718
- DOI
  10.1016/j.antiviral.2020.104718
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K10036
[Journal Article] Influenza A(H1N1)pdm09 virus exhibiting reduced susceptibility to baloxavir due to a PA E23K substitution detected from a child without baloxavir treatment2020
- Author(s)
  Takashita Emi、Abe Takashi、Morita Hiroko、Nagata Shiho、Fujisaki Seiichiro、Miura Hideka、Shirakura Masayuki、Kishida Noriko、Nakamura Kazuya、Kuwahara Tomoko、Mitamura Keiko、Ichikawa Masataka、Yamazaki Masahiko、Watanabe Shinji、Hasegawa Hideki et al.
- Journal Title
  
  Antiviral Research
  
  Volume: 180 Pages: 104828-104828
- DOI
  10.1016/j.antiviral.2020.104828
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K10036
[Journal Article] Detection of influenza A(H3N2) viruses exhibiting reduced susceptibility to the novel cap-dependent endonuclease inhibitor baloxavir in Japan, December 2018.2019
- Author(s)
  Takashita E, Kawakami C, Morita H, Ogawa R, Fujisaki S, Shirakura M, Miura H, Nakamura K, Kishida N, Kuwahara T, Mitamura K, Abe T, Ichikawa M, Yamazaki M, Watanabe S, Odagiri T, On Behalf Of The Influenza Virus Surveillance Group Of Japan.
- Journal Title
  
  Euro Surveill.
  
  Volume: 24 Issue: 3 Pages: 1800698-1800698
- DOI
  10.2807/1560-7917.es.2019.24.3.1800698
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K10036
[Journal Article] Influenza A(H3N2) virus exhibiting reduced susceptibility to baloxavir due to a polymerase acidic subunit I38T substitution detected from a hospitalised child without prior baloxavir treatment, Japan, January 2019.2019
- Author(s)
  Takashita E, Kawakami C, Ogawa R, Morita H, Fujisaki S, Shirakura M, Miura H, Nakamura K, Kishida N, Kuwahara T, Ota A, Togashi H, Saito A, Mitamura K, Abe T, Ichikawa M, Yamazaki M, Watanabe S, Odagiri T.
- Journal Title
  
  Euro Surveill.
  
  Volume: 24 Issue: 12 Pages: 1900170-1900170
- DOI
  10.2807/1560-7917.es.2019.24.12.1900170
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K10036
[Journal Article] Human-to-Human Transmission of Influenza A(H3N2) Virus with Reduced Susceptibility to Baloxavir, Japan, February 20192019
- Author(s)
  Takashita Emi、Ichikawa Masataka、Morita Hiroko、Ogawa Rie、Fujisaki Seiichiro、Shirakura Masayuki、Miura Hideka、Nakamura Kazuya、Kishida Noriko、Kuwahara Tomoko、Sugawara Hiromi、Sato Aya、Akimoto Miki、Mitamura Keiko、Abe Takashi、Yamazaki Masahiko、Watanabe Shinji、Hasegawa Hideki、Odagiri Takato
- Journal Title
  
  Emerging Infectious Diseases
  
  Volume: 25 Issue: 11 Pages: 2108-2111
- DOI
  10.3201/eid2511.190757
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K10036
[Journal Article] Susceptibility of Influenza Viruses to the Novel Cap-Dependent Endonuclease Inhibitor Baloxavir Marboxil.2018
- Author(s)
  Takashita E, Morita H, Ogawa R, Nakamura K, Fujisaki S, Shirakura M, Kuwahara T, Kishida N, Watanabe S, Odagiri T.
- Journal Title
  
  Front Microbiol.
  
  Volume: 9 Pages: 3026-3026
- DOI
  10.3389/fmicb.2018.03026
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K10036
[Journal Article] Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors and status of novel antivirals, 2016-2017.2018
- Author(s)
  Lackenby A, Besselaar TG, Daniels RS, Fry A, Gregory V, Gubareva LV, Huang W, Hurt AC, Leang SK, Lee RTC, Lo J, Lollis L, Maurer-Stroh S, Odagiri T, Pereyaslov D, Takashita E, Wang D, Zhang W, Meijer A.
- Journal Title
  
  Antiviral Res.
  
  Volume: 157 Pages: 38-46
- DOI
  10.1016/j.antiviral.2018.07.001
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K10036
[Journal Article] Influenza A(H1N1)pdm09 virus exhibiting enhanced cross-resistance to oseltamivir and peramivir due to a dual H275Y/G147R substitution, Japan, March 2016.2016
- Author(s)
  Takashita E, Fujisaki S, Shirakura M, Nakamura K, Kishida N, Kuwahara T, Shimazu Y, Shimomura T, Watanabe S, Odagiri T; Influenza Virus Surveillance Group of Japan.
- Journal Title
  
  Euro Surveill.
  
  Volume: 21 Issue: 24 Pages: 30258-30258
- DOI
  10.2807/1560-7917.es.2016.21.24.30258
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460816
[Journal Article] TMPRSS2 Independency for Haemagglutinin Cleavage In Vivo Differentiates Influenza B Virus from Influenza A Virus.2016
- Author(s)
  Sakai K, Ami Y, Nakajima N, Nakajima K, Kitazawa M, Anraku M, Takayama I, Sangsriratanakul N, Komura M, Sato Y, Asanuma H, Takashita E, Komase K, Takehara K, Tashiro M, Hasegawa H, Odagiri T, Takeda M.
- Journal Title
  
  Sci Rep.
  
  Volume: 6 Issue: 1 Pages: 29430-29430
- DOI
  10.1038/srep29430
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26460816, KAKENHI-PROJECT-16K15041, KAKENHI-PROJECT-15H04596
[Journal Article] Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, 2014-2015.2016
- Author(s)
  Hurt AC, Besselaar TG, Daniels RS, Ermetal B, Fry A, Gubareva L, Huang W, Lackenby A, Lee RT, Lo J, Maurer-Stroh S, Nguyen HT, Pereyaslov D, Rebelo-de-Andrade H, Siqueira MM, Takashita E, Tashiro M, Tilmanis D, Wang D, Zhang W, Meijer A.
- Journal Title
  
  Antiviral Res.
  
  Volume: 132 Pages: 178-185
- DOI
  10.1016/j.antiviral.2016.06.001
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460816
[Journal Article] Characterization of an A (H1N1)pdm09 Virus Imported from India in March 20152016
- Author(s)
  Takashita E, Fujisaki S, Shirakura M, Nakamura K, Kishida N, Kuwahara T, Ohmiya S, Sato K, Ito H, Chiba F, Nishimura H, Shindo S, Watanabe S, Odagiri T; Influenza Virus Surveillance Group of Japan.
- Journal Title
  
  Jpn J Infect Dis
  
  Volume: 69 Issue: 1 Pages: 83-86
- DOI
  10.7883/yoken.JJID.2015.460
- NAID
  130005120243
- ISSN
  1344-6304, 1884-2836
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460816
[Journal Article] Antiviral susceptibility of influenza viruses isolated from patients pre- and post-administration of favipiravir.2016
- Author(s)
  Takashita E, Ejima M, Ogawa R, Fujisaki S, Neumann G, Furuta Y, Kawaoka Y, Tashiro M, Odagiri T.
- Journal Title
  
  Antiviral Res.
  
  Volume: 132 Pages: 170-177
- DOI
  10.1016/j.antiviral.2016.06.007
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460816
[Journal Article] 4th isirv-AVG Conference Novel Antiviral Therapies for Influenza and other Respiratory参加報告2015
- Author(s)
  高下恵美
- Journal Title
  
  インフルエンザ
  
  Volume: 56 Pages: 228-9
- Data Source
  KAKENHI-PROJECT-26460816
[Journal Article] Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, 2013-2014.2015
- Author(s)
  Takashita E, Meijer A, Lackenby A, Gubareva L, Rebelo-de-Andrade H, Besselaar T, Fry A, Gregory V, Leang SK, Huang W, Lo J, Pereyaslov D, Siqueira MM, Wang D, Mak GC, Zhang W, Daniels RS, Hurt AC, Tashiro M.
- Journal Title
  
  Antiviral Res.
  
  Volume: 117 Pages: 27-38
- DOI
  10.1016/j.antiviral.2015.02.003
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460816
[Journal Article] C646, a Novel p300/CREB-Binding Protein-Specific Inhibitor of Histone Acetyltransferase, Attenuates Influenza A Virus Infection.2015
- Author(s)
  Zhao D, Fukuyama S, Sakai-Tagawa Y, Takashita E, Shoemaker JE, Kawaoka Y.
- Journal Title
  
  Antimicrob Agents Chemother.
  
  Volume: 60 Issue: 3 Pages: 1902-6
- DOI
  10.1128/aac.02055-15
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460816, KAKENHI-PROJECT-23590145
[Journal Article] Characterization of a Large Cluster of Influenza A(H1N1)pdm09 Viruses Cross-Resistant to Oseltamivir and Peramivir during the 2013-2014 Influenza Season in Japan.2015
- Author(s)
  Takashita E, Kiso M, Fujisaki S, Yokoyama M, Nakamura K, Shirakura M, Sato H, Odagiri T, Kawaoka Y, Tashiro M.
- Journal Title
  
  Antimicrob Agents Chemother.
  
  Volume: 59 Issue: 5 Pages: 2607-2617
- DOI
  10.1128/aac.04836-14
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460816
[Journal Article] 6SLN-lipo PGA specifically catches (coats) human influenza virus and synergizes neuraminidase-targeting drugs for human influenza therapeutic potential.2015
- Author(s)
  Sriwilaijaroen N, Suzuki K, Takashita E, Hiramatsu H, Kanie O, Suzuki Y.
- Journal Title
  
  J Antimicrob Chemother.
  
  Volume: 70 Issue: 10 Pages: 2797-80
- DOI
  10.1093/jac/dkv193
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460816
[Journal Article] タミフル・ラピアクタ耐性インフルエンザウイルス2015
- Author(s)
  高下恵美
- Journal Title
  
  医学のあゆみ
  
  Volume: 252 Pages: 312-313
- Data Source
  KAKENHI-PROJECT-26460816
[Journal Article] 抗インフルエンザ薬と薬剤耐性ウイルス2015
- Author(s)
  高下恵美、河岡義裕、田村大輔
- Journal Title
  
  インフルエンザ
  
  Volume: 16 Pages: 7-13
- Data Source
  KAKENHI-PROJECT-26460816
[Journal Article] 抗インフルエンザ薬耐性A(H1N1)pdm09インフルエンザの流行2014
- Author(s)
  高下恵美
- Journal Title
  
  感染・炎症・免疫
  
  Volume: 44 Pages: 75-76
- Data Source
  KAKENHI-PROJECT-26460816
[Journal Article] Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, 2012-2013.2014
- Author(s)
  Meijer A, Rebelo-de-Andrade H, Correia V, Besselaar T, Drager-Dayal R, Fry A, Gregory V, Gubareva L, Kageyama T, Lackenby A, Lo J, Odagiri T, Pereyaslov D, Siqueira MM, Takashita E, Tashiro M, Wang D, Wong S, Zhang W, Daniels RS, Hurt AC.
- Journal Title
  
  Antiviral Res.
  
  Volume: 110 Pages: 31-41
- DOI
  10.1016/j.antiviral.2014.07.001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26460816
[Journal Article] 各都道府県の抗インフルエンザ薬耐性ウイルス調査はどのように行われているのでしょうか2014
- Author(s)
  高下恵美
- Journal Title
  
  インフルエンザ
  
  Volume: 15 Pages: 22-22
- Data Source
  KAKENHI-PROJECT-26460816
[Journal Article] 耐性インフルエンザウイルスの動向2014
- Author(s)
  高下恵美
- Journal Title
  
  臨床と研究
  
  Volume: 91 Pages: 45-48
- Data Source
  KAKENHI-PROJECT-26460816
[Journal Article] インフルエンザウイルスのHA蛋白糖鎖と免役応答2006
- Author(s)
  高下恵美ら
- Journal Title
  
  感染・炎症・免疫 35
  
  Pages: 322-325
- Data Source
  KAKENHI-PROJECT-16017214
[Presentation] SARS-CoV-2 resistance to antibodies and protease inhibitors2023
- Author(s)
  Emi Takashita
- Organizer
  The 2nd isirv Antiviral Group Webinar Series
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K10036
[Presentation] 2022/23インフルエンザシーズンにおける薬剤未投与例からのバロキサビル耐性変異ウイルスの検出2023
- Author(s)
  高下恵美
- Organizer
  第55回日本小児感染症学会
- Data Source
  KAKENHI-PROJECT-18K10036
[Presentation] 2021/22シーズンに横浜市で分離したAH3インフルエンザウイルスの解析2022
- Author(s)
  川上千春、清水耕平、小澤広規、宇宿秀三、大久保一郎、高下恵美、藤崎誠一郎、岸田典子、中村一哉、渡邉真治
- Organizer
  第35回インフルエンザ研究者交流の会シンポジウム
- Data Source
  KAKENHI-PROJECT-18K10036
[Presentation] COVID-19流行下における小児のライノウイルス感染リスクの上昇2022
- Author(s)
  高下恵美
- Organizer
  第125回日本小児科学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-18K10036
[Presentation] SARS-CoV-2に対するCOVID-19治療薬の効果について2022
- Author(s)
  高下恵美
- Organizer
  第89回日本呼吸器学会・日本結核非結核性抗酸菌症学会・日本サルコイドーシス/肉芽腫性疾患学会九州支部秋季学術講演会
- Invited
- Data Source
  KAKENHI-PROJECT-18K10036
[Presentation] Characterizations of circulating influenza viruses in the 2020/21 season and selection of vaccine viruses for the 2021/22 season2021
- Author(s)
  Watanabe S, Nakamura K, Kishida N, Fujisaki S, Shirakura M, Takashita E, T Kuwahara, Sato A, Akimoto M, Miura H, Morita H, Sugawara H, Hasegawa, H The influenza surveillance group of Japan
- Organizer
  第68回日本ウイルス学会
- Data Source
  KAKENHI-PROJECT-18K10036
[Presentation] 新型コロナウイルス感染症流行下における小児のライノウイルス感染リスクの上昇2021
- Author(s)
  高下恵美、川上千春、百木智子、七種美和子、清水耕平、小澤広規、熊崎真琴、宇宿秀三、田中伸子、大久保一郎、森田博子、永田志保、渡邉真治、長谷川秀樹、河岡義裕
- Organizer
  第34回インフルエンザ研究者交流の会シンポジウム
- Data Source
  KAKENHI-PROJECT-18K10036
[Presentation] 新型コロナウイルス感染症流行下における小児のライノウイルス感染リスクの上昇2021
- Author(s)
  高下恵美、川上千春、百木智子、七種美和子、清水耕平、小澤広規、熊崎真琴、宇宿秀三、田中伸子、大久保一郎、森田博子、永田志保、渡邉真治、長谷川秀樹、河岡義裕
- Organizer
  第68回日本ウイルス学会
- Data Source
  KAKENHI-PROJECT-18K10036
[Presentation] Increased risk of rhinovirus infection in children during the coronavirus disease-19 pandemic2021
- Author(s)
  Takashita E, Kawakami C, Momoki T, Saikusa M, Shimizu K, Ozawa H, Kumazaki M, Usuku S, Tanaka N, Okubo I, Morita H, Nagata S, Watanabe S, Hasegawa H, Kawaoka Y
- Organizer
  ISIRV-WHO Virtual Conference: COVID-19, Influenza and RSV: Surveillance-Informed Prevention and Treatment
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K10036
[Presentation] 新型コロナウイルス感染症流行下における小児のライノウイルス感染リスクの上昇2021
- Author(s)
  高下恵美、川上千春、百木智子、七種美和子、清水耕平、小澤広規、熊崎真琴、宇宿秀三、田中伸子、大久保一郎、森田博子、永田志保、渡邉真治、長谷川秀樹、河岡義裕
- Organizer
  第53回小児感染症学会
- Data Source
  KAKENHI-PROJECT-18K10036
[Presentation] 2017/18 シーズンから2019/20 シーズンに流行したAH1pdm09 インフルエンザウイルスの解析2021
- Author(s)
  川上千春、百木智子、七種美和子、清水耕平、小澤広規、宇宿秀三、田中伸子、大久保一郎、高下恵美、藤崎誠一郎、中村一哉、岸田典子、渡邉真治、長谷川秀樹
- Organizer
  第34回インフルエンザ研究者交流の会シンポジウム
- Data Source
  KAKENHI-PROJECT-18K10036
[Presentation] Antiviral resistance: frequency of resistance, impact on patient, risk of transmission2020
- Author(s)
  Emi Takashita
- Organizer
  APACI 2020 Webinar Series on Pandemic Preparedness
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K10036
[Presentation] 過去3シーズンに流行したAH1pdm09インフルエンザウイルスの解析2020
- Author(s)
  川上千春、七種美和子、清水耕平、小澤広規、宇宿秀三、高下恵美、藤崎誠一郎、中村一哉、岸田典子、渡邉真治
- Organizer
  第52回日本小児感染症学会
- Data Source
  KAKENHI-PROJECT-18K10036
[Presentation] 2018-19シーズンにおけるバロキサビル耐性変異ウイルスの検出状況2020
- Author(s)
  高下恵美、森田博子、永田志保、藤崎誠一郎、白倉雅之、中村一哉、岸田典子、桑原朋子、渡邉真治、長谷川秀樹
- Organizer
  9tn Negative Strand Virus-Japan
- Data Source
  KAKENHI-PROJECT-18K10036
[Presentation] インフルエンザウイルスの薬剤耐性株サーベイランス2019
- Author(s)
  高下恵美
- Organizer
  第33回日本臨床内科医学会
- Invited
- Data Source
  KAKENHI-PROJECT-18K10036
[Presentation] 新規抗インフルエンザ薬バロキサビルマルボキシルに対する耐性株サーベイランス.2019
- Author(s)
  高下恵美, 森田博子, 小川理恵, 中村一哉, 藤崎誠一郎, 白倉雅之, 桑原朋子, 岸田典子, 三浦秀佳, 秋元未来, 佐藤彩, 菅原裕美, 渡邉真治, 小田切孝人.
- Organizer
  8th Negative Strand Virus-Japan.
- Data Source
  KAKENHI-PROJECT-18K10036
[Presentation] Human-to-human transmission of influenza A(H3N2) viruses exhibiting reduced susceptibility to baloxavir due to a PA I38T substitution in Japan2019
- Author(s)
  Emi Takashita, Rie Ogawa, Hiroko Morita, Seiichiro Fujisaki, Masayuki Shirakura, Hideka Miura, Kazuya Nakamura, Noriko Kishida, Tomoko Kuwahara, Hiromi Sugawara, Aya Sato, Miki Akimoto, Keiko Mitamura, Takashi Abe, Masataka Ichikawa, Masahiko Yamazaki, Shinji Watanabe, Takato Odagiri
- Organizer
  Options X for the Control of Influenza
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K10036
[Presentation] Human-to-human transmission of influenza A(H3N2) viruses exhibiting reduced susceptibility to baloxavir due to a PA I38T substitution in Japan2019
- Author(s)
  Emi Takashita, Hiroko Morita, Rie Ogawa, Seiichiro Fujisaki, Masayuki Shirakura, Hideka Miura, Kazuya Nakamura, Noriko Kishida, Tomoko Kuwahara, Hiromi Sugawara, Aya Sato, Miki Akimoto, Keiko Mitamura, Takashi Abe, Masataka Ichikawa, Masahiko Yamazaki, Shinji Watanabe, Takato Odagiri, Hideki Hasegawa
- Organizer
  第67回日本ウイルス学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K10036
[Presentation] インフルエンザウイルスのグローバルサーベイランス2019
- Author(s)
  高下恵美
- Organizer
  第60回日本臨床ウイルス学会
- Invited
- Data Source
  KAKENHI-PROJECT-18K10036
[Presentation] 抗インフルエンザ薬耐性株サーベイランス2019
- Author(s)
  高下恵美
- Organizer
  第93回日本感染症学会
- Invited
- Data Source
  KAKENHI-PROJECT-18K10036
[Presentation] 新規抗インフルエンザ薬バロキサビルに対する耐性株サーベイランス2019
- Author(s)
  高下恵美
- Organizer
  第33回インフルエンザ研究者交流の会シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-18K10036
[Presentation] 2018/2019シーズンにおける新規抗インフルエンザ薬バロキサビル耐性変異ウイルスの検出状況2019
- Author(s)
  高下恵美　藤崎誠一郎　白倉雅之　中村一哉　岸田典子　桑原朋子　三田村敬子　安倍隆　市川正孝　山崎雅彦渡邉真治　小田切孝人　長谷川秀樹
- Organizer
  第51回日本小児感染症学会
- Data Source
  KAKENHI-PROJECT-18K10036
[Presentation] Susceptibility of influenza viruses to the novel cap-dependent endonuclease inhibitor baloxavir marboxil.2018
- Author(s)
  Takashita E, Morita H, Ogawa R, Nakamura K, Fujisaki S, Shirakura M, Kuwahara T, Kishida N, Mitamura K, Abe T, Ichikawa M, Yamazaki M, Watanabe S, Odagiri T.
- Organizer
  6th isirv Antiviral Group Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K10036
[Presentation] 日本国内で検出されたA(H1N1)pdm09二重耐性変異ウイルスの性状解析.2017
- Author(s)
  高下恵美.
- Organizer
  6th Negative Strand Virus-Japan
- Place of Presentation
  沖縄
- Year and Date
  2017-01-16
- Data Source
  KAKENHI-PROJECT-26460816
[Presentation] 日本国内におけるNA阻害薬耐性インフルエンザウイルス検出状況2016
- Author(s)
  高下恵美
- Organizer
  5th Negative Strand Virus-Japan
- Place of Presentation
  ホテルモントレ沖縄 (沖縄県国頭郡)
- Year and Date
  2016-01-25
- Data Source
  KAKENHI-PROJECT-26460816
[Presentation] Detection of influenza A(H1N1)pdm09 viruses exhibiting enhanced cross-resistance to oseltamivir and peramivir in the 2015/16 season.2016
- Author(s)
  Takashita E, Fujisaki S, Shirakura M, Nakamura K, Kishida N, Kuwahara T, Shimazu Y, Shimomura T, Doi I, Watanabe S, Odagiri T, The Influenza Virus Surveillance Group of Japan.
- Organizer
  第64回日本ウイルス学会
- Place of Presentation
  札幌
- Year and Date
  2016-10-23
- Data Source
  KAKENHI-PROJECT-26460816
[Presentation] Antiviral susceptibility of influenza viruses isolated from patients pre-and post-administration of favipiravir.2016
- Author(s)
  Takashita E, Ejima M, Ogawa R, Fujisaki S, Neumann G, Furuta Y, Kawaoka Y, Tashiro M, Odagiri T.
- Organizer
  Options IX for the Control of Influenza
- Place of Presentation
  Chicago, USA.
- Year and Date
  2016-08-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460816
[Presentation] 2015/16シーズンに検出されたオセルタミビル・ペラミビルに強い耐性を示すインフルエンザウイルス.2016
- Author(s)
  高下恵美, 小川理恵, 藤崎誠一郎, 白倉雅之, 三浦秀佳, 中村一哉, 岸田典子, 桑原朋子, 菅原裕美, 佐藤彩, 秋元未来, 渡邉真治, 小田切孝人.
- Organizer
  第48回日本小児感染症学会
- Place of Presentation
  岡山
- Year and Date
  2016-11-19
- Data Source
  KAKENHI-PROJECT-26460816
[Presentation] 2014/15シーズンにおける日本国内の抗インフルエンザ薬耐性ウイルス検出状況2015
- Author(s)
  高下恵美、小川理恵、藤崎誠一郎、中村一哉、白倉雅之、岸田典子、桑原朋子、菅原裕美、佐藤彩、三浦秀佳、秋元未来、渡邉真治、小田切孝人
- Organizer
  第47回日本小児感染症学会
- Place of Presentation
  ザ・セレクトン福島、ホテル福島グリーンパレス、コラッセふくしま (福島県福島市)
- Year and Date
  2015-10-31
- Data Source
  KAKENHI-PROJECT-26460816
[Presentation] Antiviral susceptibility of influenza viruses isolated from patients pre- and post-administration of favipiravir2015
- Author(s)
  Takashita E, Fujisaki S, Neumann G, Furuta Y, Kawaoka Y, Tashino M, Odagiri T.
- Organizer
  第63回日本ウイルス学会
- Place of Presentation
  福岡国際会議場 (福岡県福岡市)
- Year and Date
  2015-11-22
- Data Source
  KAKENHI-PROJECT-26460816
[Presentation] Characterization of a Large Cluster of Influenza A(H1N1)pdm09 Virus Cross-Resistant to Oseltamivir and Peramivir during the 2013-2014 Influenza Season in Japan2015
- Author(s)
  Takashita E, Kiso M, Fujisaki S, Yokohama M, Nakamura K, Shirakura M, Sato H, Odagiri T, Kawaoka Y, Tashino M.
- Organizer
  4th ISIRV-AVG Conference
- Place of Presentation
  University of Texas at Austin (Texas, USA)
- Year and Date
  2015-06-02
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460816
[Presentation] 2013/14シーズンにおけるNA阻害剤耐性A(H1N1)pdm09ウイルスの地域流行
- Author(s)
  高下恵美、江島美穂、藤崎誠一郎、横山勝、中村一哉、白倉雅之、菅原裕美、佐藤彩、佐藤裕徳、小田切孝人、全国地方衛生研究所
- Organizer
  第62回日本ウイルス学会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2014-11-10 – 2014-11-12
- Data Source
  KAKENHI-PROJECT-26460816
[Presentation] 札幌市を中心とした抗インフルエンザ薬耐性ウイルスの地域流行
- Author(s)
  高下恵美、江島美穂、藤崎誠一郎、中村一哉、白倉雅之、菅原裕美、佐藤　彩、小田切孝人
- Organizer
  第28回インフルエンザ研究者交流の会シンポジウム
- Place of Presentation
  鳥取市総合福祉センター（鳥取県鳥取市）
- Year and Date
  2014-07-04 – 2014-07-06
- Data Source
  KAKENHI-PROJECT-26460816
[Presentation] オセルタミビル・ペラミビル耐性A(H1N1)pdm09インフルエンザウイルスの地域流行
- Author(s)
  高下恵美
- Organizer
  4th Negative Strand Virus-Japan
- Place of Presentation
  ラグナガーデンホテル（沖縄県宜野湾市）
- Year and Date
  2015-01-19 – 2015-01-21
- Data Source
  KAKENHI-PROJECT-26460816
[Presentation] A community cluster of influenza A(H1N1)pdm09 virus exhibiting cross-resistance to oseltamivir and peramivir in Japan, November 2013 to February 2014
- Author(s)
  E Takashita, M Ejima, S Fujisaki, M Yokoyama, K Nakamura, M Shirakura, H Sugawara, A Sato, H Sato, M Tashiro, T Odagiri
- Organizer
  5th ESWI Influenza Conference
- Place of Presentation
  Radisson Blu Hotel Latvija (Riga, Latvia)
- Year and Date
  2014-09-14 – 2014-09-17
- Data Source
  KAKENHI-PROJECT-26460816
[Presentation] A community cluster of influenza A(H1N1)pdm09 virus exhibiting cross-resistance to oseltamivir and peramivir in Japan
- Author(s)
  E Takashita, M Ejima, S Fujisaki, K Nakamura, A Sato, H Sugawara, M Tashiro and T Odagiri
- Organizer
  3rd isirv-AVG Conference; Influenza and other Respiratory Virus Infections: Advances in Clinical Management
- Place of Presentation
  Keio Plaza Hotel (Tokyo, Japan)
- Year and Date
  2014-06-04 – 2014-06-06
- Data Source
  KAKENHI-PROJECT-26460816
[Presentation] 2013/14シーズンにおける抗インフルエンザ薬耐性ウイルスの地域流行と高度耐性ウイルスの検出について
- Author(s)
  高下恵美、江島美穂、藤崎誠一郎、中村一哉、白倉雅之、菅原裕美、佐藤彩、小田切孝人
- Organizer
  第46回日本小児感染症学会
- Place of Presentation
  京王プラザホテル（東京都新宿区）
- Year and Date
  2014-10-18 – 2014-10-19
- Data Source
  KAKENHI-PROJECT-26460816

1. SATO Masatoki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 橋本浩一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 細矢光亮

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Takashita Emi 高下 恵美

高下 恵美 タカシタ エミ

Research Projects

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Establishment of a detection system for antiviral-resistant influenza virusesPrincipal Investigator

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Detection of antiviral-resistant influenza virusesPrincipal Investigator

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インフルエンザウイルスのHA亜型とNA亜型の組み合わせは生存のための必要条件かPrincipal Investigator

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インフルエンザウイルスにおけるHA蛋白への糖鎖付加による免疫回避機構の解明Principal Investigator

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[Book] インフルエンザ診療ガイド2016-172016

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[Book] インフルエンザ診療ガイド2015-162015

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[Book] インフルエンザ診療ガイド2014-152014

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[Journal Article] Antiviral Susceptibilities of Distinct Lineages of Influenza C and D Viruses2023

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[Journal Article] Assessment of the frequency of SARS-CoV-2 Omicron variant escape from RNA-dependent RNA polymerase inhibitors and 3C-like protease inhibitors2023

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[Journal Article] A community cluster of influenza A(H3N2) virus infection with reduced susceptibility to baloxavir due to a PA E199G substitution in Japan, February to March 20232023

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[Journal Article] Clinical And Virologic Impacts of Respiratory Viral Co-infections in Children With Influenza2023

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[Journal Article] Antiviral Susceptibilities of Avian Influenza A(H5), A(H7), and A(H9) Viruses Isolated in Japan2022

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[Journal Article] Are twindemics occurring?2022

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[Journal Article] Assays for Determining the Sialidase Activity of Influenza Viruses and Monitoring Influenza Virus Susceptibility to Neuraminidase Inhibitors2022

Author(s)

Takashita Emi 高下恵美

高下恵美タカシタエミ

[Journal Article] バロキサビルマルボキシルは、NA阻害薬耐性株に対しても有効なのでしょうか2020