Daitoku Hiroaki 大徳浩照

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DAITOKU Hiroaki 大徳浩照

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Researcher Number	30361314
Other IDs	https://orcid.org/0000-0002-6535-7532
Affiliation (Current)	2024: 筑波大学, 生存ダイナミクス研究センター, 講師
Affiliation (based on the past Project Information) *help	2018 – 2024: 筑波大学, 生存ダイナミクス研究センター, 講師 2016 – 2017: 筑波大学, 生命領域学際研究センター, 講師 2014 – 2015: 筑波大学, 生命環境系, 講師 2011 – 2012: 筑波大学, 生命環境系, 講師 2007 – 2010: University of Tsukuba, 大学院・生命環境科学研究科, 講師 2006: 筑波大学, 大学院生命環境科学研究科, 講師 2004 – 2005: 筑波大学, 大学院・生命環境科学研究科, 助手
Review Section/Research Field	Principal Investigator Applied molecular and cellular biology / Basic Section 38060:Applied molecular and cellular biology-related Except Principal Investigator Biological Sciences / Applied molecular and cellular biology / Biological Sciences
Keywords	Principal Investigator 寿命 / 線虫 / 翻訳後修飾 / 転写制御 / FOXO / 転写因子 / 老化 / FOXO1 / 細胞外分泌 / タンパク質メチル化 … More / アポトーシス / 酸化ストレス / アセチル化 / メチル化酵素 / ヒスチジン / メチル化 / N結合型糖鎖修飾 / METTL9 / ヒスチジンメチル化 / グルコース / 糖代謝 / DAF-16 / 転写 / 損傷乗り越え修復 / DNA損傷 / 損傷乗り越え複製 / 損傷乗り越えDNA複製 / DNA損傷修復 / 紫外線 / 脱アセチル化 / Sir2 / 胆汁酸 / 糖新生 / Foxol / CBP / インスリン / 多重修飾 / 2型糖尿病 / リン酸化 / Foxo1 … More Except Principal Investigator メチル化 / 老化 / ストレス耐性 / -adenosylmethionine / 寿命 / 栄養 / メチオニン代謝 / LC-MS/MS / 転写 / アセチルCoA / S-adenosylmethionine / 線虫 / S-アデノシルメチオニン / 出産 / 少子高齢化 / マイクロアレー / アポトーシス / 母胎 / レニンーアンジオテンシン系 / 胎盤 / 血管弛緩 / 血管収縮 / 摘出血管 / 母体 / 胎児発育遅延 / 妊娠高血圧 / 胎児-胎盤系 / アペリン-APJ受容体 / トランスジェニックマウス / 子宮内発育遅延 / レニン-アンジオテンシン系 / 母胎間ネットワーク / 妊娠高血圧症候群 / 妊娠中毒症 / コアクチベーター / EWS / 脱アセチル化 / インスリン応答性 / アルギニンメチル化酵素 / グリシン-アルギニンタンパク質 / アセチルか / タンパク質修飾 / E3リガーゼ / アレルギンメチル化 / 複製 / 修復 / UV損傷 / 酸化ストレス / 複合体精製 / フォークヘッド / 食シグナル / アルギニンメチル化コード / アルギニンメチル化 / ユビキチン化 / アセチル化 / リン酸化 / フォークヘッド転写因子 / 翻訳後修飾 Less

細胞外環境におけるタンパク質メチル化酵素の生物学的役割の解明Principal Investigator
- Principal Investigator
  
  大徳浩照
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 38060:Applied molecular and cellular biology-related
- Research Institution
  University of Tsukuba
Elucidation of the regulatory mechanism and biological significance of histidine methyltransferase METTL9Principal Investigator
- Principal Investigator
  
  Daitoku Hiroaki
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 38060:Applied molecular and cellular biology-related
- Research Institution
  University of Tsukuba
Relationship between glucose metabolism and FOXO1 acetylation through acetyl-CoAPrincipal Investigator
- Principal Investigator
  
  Daitoku Hiroaki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied molecular and cellular biology
- Research Institution
  University of Tsukuba
In vivo analysis of longevity mechanism of transcription factor DAF-16/FOXOPrincipal Investigator
- Principal Investigator
  
  DAITOKU Hiroaki
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied molecular and cellular biology
- Research Institution
  University of Tsukuba
Crosstalk of transcriptional status and amino acid metabolism
- Principal Investigator
  
  FUKAMIZU Akiyoshi
- Project Period (FY)
  2011 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  University of Tsukuba
Functional analysis of DNA damage response of transcription factor FOXO1 in lifespan regulationPrincipal Investigator
- Principal Investigator
  
  DAITOKU Hiroaki
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Applied molecular and cellular biology
- Research Institution
  University of Tsukuba
Analysis for regulation of transcription factor FOXO1 by post-translational modification and mechanism of determination of lifspanPrincipal Investigator
- Principal Investigator
  
  DAITOKU Hiroaki
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied molecular and cellular biology
- Research Institution
  University of Tsukuba
代謝と寿命をつなぐ転写因子FOXO1の多重修飾制御機構の解明Principal Investigator
- Principal Investigator
  
  大徳浩照
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied molecular and cellular biology
- Research Institution
  University of Tsukuba
Elucidation of DECODE cycle that regulates homeostasis mediated by protein modification.
- Principal Investigator
  
  FUKAMIZU Akiyoshi
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  University of Tsukuba
Feto-maternal network on pregnancy-induced hypertension
- Principal Investigator
  
  FUKAMIZU Akiyoshi
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Applied molecular and cellular biology
- Research Institution
  University of Tsukuba
転写因子Foxolの多重修飾制御機構に関する研究Principal Investigator
- Principal Investigator
  
  大徳浩照
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied molecular and cellular biology
- Research Institution
  University of Tsukuba

[Book] 栄養・代謝物シグナルと食品機能2022
- Author(s)
  大徳浩照、深水昭吉
- Total Pages
  235
- Publisher
  羊土社
- ISBN
  9784758104029
- Data Source
  KAKENHI-PROJECT-20H02947
[Book] エッセンシャル栄養化学2021
- Author(s)
  加香孝一郎、大徳浩照、深水昭吉
- Total Pages
  305
- Publisher
  講談社サイエンティフィク
- ISBN
  9784065238066
- Data Source
  KAKENHI-PROJECT-20H02947
[Book] 実験医学　特集 RNAが修飾される2018
- Author(s)
  宮田真衣、大徳浩照、深水昭吉
- Total Pages
  4
- Publisher
  羊土社
- ISBN
- Data Source
  KAKENHI-PROJECT-17K08193
[Book] 深水昭吉FOXOとアンチエイジング医学アンチエイジング医学の基礎と臨床改訂2版2008
- Author(s)
  大徳浩照
- Publisher
  メディカルビュー社
- Data Source
  KAKENHI-PROJECT-20780237
[Journal Article] Histidine Nτ-methylation identified as a new posttranslational modification in histone H2A at His-82 and H3 at His-392023
- Author(s)
  Hayashi Takahiro、Daitoku Hiroaki、Uetake Toru、Kako Koichiro、Fukamizu Akiyoshi
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 299 Issue: 9 Pages: 105131-105131
- DOI
  10.1016/j.jbc.2023.105131
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23H00321, KAKENHI-PROJECT-20H02947
[Journal Article] γ-enolase (ENO2) is methylated at the <i>N</i>τ position of His-190 among enolase isozymes2023
- Author(s)
  Kasai Fumiya、Kako Koichiro、Maruhashi Syunsuke、Uetake Toru、Yao Yuan、Daitoku Hiroaki、Fukamizu Akiyoshi
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: 174 Issue: 3 Pages: 279-289
- DOI
  10.1093/jb/mvad042
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23H00321, KAKENHI-PROJECT-20H02947
[Journal Article] siRNA screening identifies METTL9 as a histone Nπ-methyltransferase that targets the proinflammatory protein S100A92021
- Author(s)
  Daitoku H., Someya M., Kako K., Hayashi T., Tajima T., Haruki H., Sekiguchi N., Uetake T., Akimoto Y., and Fukamizu A.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 297 Issue: 5 Pages: 101230-101230
- DOI
  10.1016/j.jbc.2021.101230
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H02947
[Journal Article] Identification of a novel nucleolar protein complex required for mitotic chromosome segregation through centromeric accumulation of Aurora B2020
- Author(s)
  Fujimura, A., Hayashi, Y., Kato, K., Kogure, Y., Kameyama, M., Shimamoto, H., Daitoku, H., Fukamizu, A., Hirota, T., and Kimura, K.
- Journal Title
  
  Nucleic Acids Res.
  
  Volume: 48 Issue: 12 Pages: 6583-6596
- DOI
  10.1093/nar/gkaa449
- NAID
  120007147865
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H01519, KAKENHI-PROJECT-18H04034, KAKENHI-PROJECT-19H03257, KAKENHI-PROJECT-20H02947
[Journal Article] Tricarboxylic acid cycle activity suppresses acetylation of mitochondrial proteins during early embryonic development in Caenorhabditis elegans.2019
- Author(s)
  Hada Kazumasa、Hirota Keiko、Inanobe Ai、Kako Koichiro、Miyata Mai、Araoi Sho、Matsumoto Masaki、Ohta Reiya、Arisawa Mitsuhiro、Daitoku Hiroaki、Hanada Toshikatsu、Fukamizu Akiyoshi
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 294 Issue: 9 Pages: 3091-3099
- DOI
  10.1074/jbc.ra118.004726
- NAID
  120007133475
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K01942, KAKENHI-PROJECT-17K07746, KAKENHI-PROJECT-17K08193, KAKENHI-PROJECT-17K19919, KAKENHI-PROJECT-17K15623, KAKENHI-PUBLICLY-17H05534, KAKENHI-PUBLICLY-17H06011, KAKENHI-PROJECT-16H05154, KAKENHI-PROJECT-17H01519, KAKENHI-PROJECT-26288051, KAKENHI-PUBLICLY-18H04260, KAKENHI-PROJECT-15KT0063
[Journal Article] The GATA transcription factor ELT-2 modulates both the expression and methyltransferase activity of PRMT-1 in Caenorhabditis elegans2018
- Author(s)
  Araoi Sho、Daitoku Hiroaki、Yokoyama Atsuko、Kako Koichiro、Hirota Keiko、Fukamizu Akiyoshi
- Journal Title
  
  J. Biochem.
  
  Volume: 印刷中 Issue: 5 Pages: 433-440
- DOI
  10.1093/jb/mvy012
- NAID
  40021555333
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K01942, KAKENHI-PROJECT-17K07746, KAKENHI-PROJECT-17K08193, KAKENHI-PROJECT-17H01519, KAKENHI-PROJECT-26350957, KAKENHI-PROJECT-26450119, KAKENHI-PROJECT-16K15087
[Journal Article] Asymmetric arginine dimethylation modulates mitochondrial energy metabolism and homeostasis in Caenorhabditis elegans.2017
- Author(s)
  Sha L, Daitoku H, Araoi S, Kaneko Y, Takahashi Y, Kako K, and Fukamizu A.
- Journal Title
  
  Mol. Cell. Biol.
  
  Volume: 37 Issue: 6 Pages: 00504-00516
- DOI
  10.1128/mcb.00504-16
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-WRAPUP-16H01688, KAKENHI-PROJECT-26350957, KAKENHI-PROJECT-17K08193
[Journal Article] Simultaneous ablation of prmt-1 and prmt-5 abolishes asymmetric and symmetric arginine dimethylations in Caenorhabditis elegans.2017
- Author(s)
  Hirota K., Shigekawa C., Araoi S., Sha L., Inagawa T., Kanou A., Kako K., Daitoku H., and Fukamizu A.
- Journal Title
  
  J. Biochem.
  
  Volume: 印刷中 Issue: 6 Pages: 521-527
- DOI
  10.1093/jb/mvw101
- NAID
  40021278532
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-WRAPUP-16H01688, KAKENHI-PROJECT-26350957, KAKENHI-PROJECT-26450119, KAKENHI-PROJECT-17K01942, KAKENHI-PROJECT-17K08193, KAKENHI-PROJECT-17H01519, KAKENHI-PROJECT-16K15087
[Journal Article] CTF18 interacts with replication protein A in response to replication stress2016
- Author(s)
  Yuta Kaneko, Hiroaki Daitoku, Chihiro Komeno, Akiyoshi Fukamizu
- Journal Title
  
  Molecular Medicine Reports
  
  Volume: 印刷中
- NAID
  120007133106
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26450500
[Journal Article] Non-transcriptional function of FOXO1/DAF-16 contributes to translesion DNA synthesis.2016
- Author(s)
  Daitoku H., Kaneko Y., Yoshimochi K., Matsumoto K., Araoi S., Sakamaki J., Takahashi Y., and Fukamizu A.
- Journal Title
  
  Mol. Cell. Biol.
  
  Volume: 36 Issue: 21 Pages: 2755-2766
- DOI
  10.1128/mcb.00265-16
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-WRAPUP-16H01688, KAKENHI-PROJECT-26450500
[Journal Article] Detection of choline and phosphatidic acid (PA) catalyzed by Phospholipase D (PLD) using MALDI-QIT-TOF/MS with 9-aminoacridine matrix2014
- Author(s)
  Park KE, Kim JD, Nagashima Y, Kako K, Daitoku H, Matsui M, Park GG, Fukamizu A
- Journal Title
  
  Bioscience, Biotechnology, and Biochemistry
  
  Volume: 78 Issue: 6 Pages: 981-988
- DOI
  10.1080/09168451.2014.910102
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25252062, KAKENHI-PROJECT-26350957, KAKENHI-PROJECT-26450500
[Journal Article] GSK3β regulates gluconeogenic gene expression through HNF4α and FOXO12012
- Author(s)
  Sakamaki, J., et al
- Journal Title
  
  J.Recept.Signal Transduct.Res.
  
  Volume: 32 Issue: 2 Pages: 96-101
- DOI
  10.3109/10799893.2012.660531
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J00366, KAKENHI-PROJECT-22688029
[Journal Article] GSK3ss regulates gluconeogenic gene expression through HNF4α and FOXO12012
- Author(s)
  Sakamaki J, Daitoku H, et al.
- Journal Title
  
  J.Recept.Transduct.Res.
  
  Volume: 32 Pages: 96-101
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22688029
[Journal Article] Asymmetric arginine dimethylation determines life span in C.elegans by regulating forkhead transcription factor DAF-162011
- Author(s)
  Takahashi Y., Daitoku H., Hirota K., Tamiya H., Yokoyama A., Kako K., Nagashima Y., Nakamura A., Shimada T., Watanabe S., Yamagata K., Yasuda K., Ishii N., Fukamizu A.
- Journal Title
  
  Cell Metabolism
  
  Volume: 13 Issue: 5 Pages: 505-516
- DOI
  10.1016/j.cmet.2011.03.017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J00386, KAKENHI-PROJECT-21510222, KAKENHI-PROJECT-22248040, KAKENHI-PROJECT-22510064, KAKENHI-PROJECT-22590666, KAKENHI-PROJECT-22688029, KAKENHI-PROJECT-23658283
[Journal Article] Regulation of FoxO transcription factors by acetylation and protein-protein interactions2011
- Author(s)
  Daitoku, H.Sakamaki, J.Fukamizu, A.
- Journal Title
  
  Biochim.Biophys.Acta.
  
  Volume: 1813 Issue: 11 Pages: 1954-1960
- DOI
  10.1016/j.bbamcr.2011.03.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J00366, KAKENHI-PROJECT-22688029
[Journal Article] The C. elegans PRMT-3 possesses a type III protein arginine methyltransferases activity2011
- Author(s)
  Takahashi Y, Daitoku H, Yokoyama A, Nakayama K, Kim JD, Fukamizu A
- Journal Title
  
  J.Recept. Signal Transduct
  
  Volume: 31 Issue: 2 Pages: 168-172
- DOI
  10.3109/10799893.2011.555768
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22688029
[Journal Article] Regulation of FoxO transcription factors by acetylation and protein-protein interactions2011
- Author(s)
  Daitoku, H.
- Journal Title
  
  Biochem.Biophys.Acta.
  
  Volume: (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22688029
[Journal Article] Regulation of FoxO transcription factors by acetylation and protein-protein interactions.2011
- Author(s)
  Daitoku, H.
- Journal Title
  
  Biochim. Biophys. Acta.
  
  Volume: 1813 Pages: 1954-960
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23116004
[Journal Article] Arginine methylation of BCL-2 antagonist of cell death (BAD) counteracts its phosphorylation and inactivation by Akt2011
- Author(s)
  Sakamaki, J., et al
- Journal Title
  
  Proc.Natl.Acad.Sci.USA
  
  Volume: 108 Issue: 15 Pages: 6085-6090
- DOI
  10.1073/pnas.1015328108
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J00366, KAKENHI-PROJECT-22248040, KAKENHI-PROJECT-22688029
[Journal Article] PCAF represses transactivation function of FOXO1 in an acetyltransferase-independent manner.2010
- Author(s)
  oshimochi K, Daitoku H, Fukamizu A.
- Journal Title
  
  J. Recept. Transduc. Res. 30
  
  Pages: 43-49
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17054004
[Journal Article] Foxo1 increases pro-inflammatory gene expression by inducing C/EBPbeta in TNF-alpha-treated adipocytes.2009
- Author(s)
  Ito Y, Daitoku H, Fukamizu A
- Journal Title
  
  Biochem. Biophys. Res. Commun. 378
  
  Pages: 290-295
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17054004
[Journal Article] Regulation of FOXO1-mediated transcription and cell proliferation by PARP-1. Biochem.2009
- Author(s)
  Sakamaki JI, Daitoku H, Yoshimochi K, Miwa M, Fukamizu A
- Journal Title
  
  Biophys. Res. Commun. 382
  
  Pages: 497-502
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17054004
[Journal Article] Regulation of FOXO1-mediated transcription and cell proliferation by PARP-1.2009
- Author(s)
  Sakamaki, J., Daitoku, H., Yoshimochi, K., Miwa, M., Fukamizu A.
- Journal Title
  
  Biochem. Biophys. Res. Commun. 382
  
  Pages: 497-502
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20780237
[Journal Article] Epigenetic control of rDNA loci in response to intracellular energy status.2008
- Author(s)
  Murayama A, Ohmori K, Fujimura A, Minami H, Yasuzawa-Tanaka K, Kuroda T, Oie S, Daitoku H, Okuwaki M, Nagata K, Fukamizu A, Kimura K, Shimizu T, Yanagisawa J.
- Journal Title
  
  Cell 133
  
  Pages: 627-639
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17054004
[Journal Article] Arginine methylation of FOXO transcription factors inhibits their phosphorylation by Akt.2008
- Author(s)
  Yamagata K, Daitoku H, Takahashi Y, Namiki K, Hisatake K, Kako K, Mukai H, Kasuya Y, Fukamizu A
- Journal Title
  
  Mol. Cell 32
  
  Pages: 221-231
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17054004
[Journal Article] Foxo1 increases pro-inflammatory gene expression by inducing C/EBPβin TNF-α-treated adipocytes2008
- Author(s)
  Ito, Y., Daitoku, H., Fukamizu, A.
- Journal Title
  
  Biochem. Biophys. Res. Commun. 378
  
  Pages: 290-295
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20780237
[Journal Article] Arginine methylation of FOXO transcription factors inhibits their nhosnhorylationby Akt2008
- Author(s)
  Yamagata, K. and Daitoku, H.
- Journal Title
  
  Molecular cell 32
  
  Pages: 221-231
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20780237
[Journal Article] Arginine methylation of FOXO transcription factors inhibits their phosphorylation by Akt2008
- Author(s)
  Yamagata K, Daitoku H, Takahashi Y, Namiki K, Hisatake K, Kako K, Mukai H, Kasuya Y, Fukamizu A.
- Journal Title
  
  Mol.Cell 32
  
  Pages: 221-231
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17108004
[Journal Article] Arginine methylation of FOXO transcription factors inhibits their phosphorylation by Akt2008
- Author(s)
  Yamagata, K., Daitoku, H., Takahashi, Y., Namiki, K., Hisatake, K., Kako, K., Mukai, H., Kasuya, Y., Fukamizu, A.
- Journal Title
  
  Mol. Cell 32
  
  Pages: 221-231
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20780237
[Journal Article] Bile acid represses the PGC-1 promoter activity via SHP-dependent manner2007
- Author(s)
  Yamagata, K., Yoshimochi, K., Daitoku, H., Hirota, K. and Fukamizu, A.
- Journal Title
  
  Int. J. Mol. Med. 19
  
  Pages: 751-756
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18780249
[Journal Article] Mitogen-activated protein kinases, Erk and p38, phosphorylate and regulate Foxo1.2007
- Author(s)
  Asada S, Daitoku H, Matsuzaki H, Saito T, Sudo T, Mukai H, Iwashita S, Kako K, Kishi T, Kasuya Y, Fukamizu A.
- Journal Title
  
  Cell Signal. 19
  
  Pages: 519-527
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17054004
[Journal Article] FOXO transcription factors in the regulatory. Networks of longevity2007
- Author(s)
  Daitoku, H, and Fukamizu, A.
- Journal Title
  
  J.Bioche 141
  
  Pages: 769-774
- NAID
  10020098181
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17054004
[Journal Article] FOXO transcription factors in the regulatory networks of longevity.2007
- Author(s)
  Daitoku H, Fukamizu A.
- Journal Title
  
  J. Biochem. 141
  
  Pages: 769-774
- NAID
  10020098181
- Data Source
  KAKENHI-PROJECT-17054004
[Journal Article] Insulin-like growth factor 1/insulin signaling activates androgen signaling through direct interactions of Foxol with androgen receptor.2007
- Author(s)
  Fan, W., Yanase, T., Morinaga, H., Okabe, T., Nomura, M., Daitoku, H., Fukamizu, A., Kato, S., Takayanagi, R., Nawata, H.
- Journal Title
  
  J.Biol.Chem. 282
  
  Pages: 7329-7338
- Data Source
  KAKENHI-PROJECT-18780249
[Journal Article] Bile acid represses the PGC-1 promoter activity via SHP-dependent manner.2007
- Author(s)
  Yamagata, K., Yoshimochi, K., Daitoku, H., Hirota, K., Fukamizu, A.
- Journal Title
  
  Int.J.Mol.Med. 5
  
  Pages: 751-756
- Data Source
  KAKENHI-PROJECT-18780249
[Journal Article] IGF1/insulin signaling activates androgen signaling through direct interactions of FOXO1 with androgen receptor2007
- Author(s)
  Fan, W., yanase, T., Morinaga, H., Okabe, T., Nomura, M., Daitoku, H., Fukamizu, A., Kato, s., Takayanagi, r. and Nawata, H.
- Journal Title
  
  J. Biol. Chem. 282
  
  Pages: 7329-7338
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18780249
[Journal Article] Insulin-like growth factor 1/insulin signaling activates androgen signaling through direct interactions of Foxo1 with androgen receptor.2007
- Author(s)
  Fan W, Yanase T, Morinaga H, Okabe T, Nomura M, Daitoku H, Fukamizu A, Kato S, Takayanagi R, Nawata H.
- Journal Title
  
  J. Biol. Chem. 282
  
  Pages: 7329-7338
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17054004
[Journal Article] Bile acid represses the peroxisome proliferator-activated receptor-gamma coactivator-1 promoter activity in a small heterodimer partner-dependent manner.2007
- Author(s)
  Yamagata K, Yoshimochi K, Daitoku H, Hirota K, Fukamizu, A.
- Journal Title
  
  Int. J. Mol. Med. 19
  
  Pages: 751-756
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17054004
[Journal Article] FOXO transcription factors in the regulatory networks of longevity2007
- Author(s)
  Daitoku, H. and Fukamizu, A.
- Journal Title
  
  J. Biochem. 141
  
  Pages: 769-774
- NAID
  10020098181
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18780249
[Journal Article] The LXXLL motif of murine forkhead transcription factor FoxO1 mediates Sirt1-dependent transcriptional activity.2006
- Author(s)
  Nakae J, Cao Y, Daitoku H, Fukamizu A, Ogawa W, Yano Y, Hayashi Y.
- Journal Title
  
  J. Clin. Invest. 116
  
  Pages: 2473-2483
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17054004
[Journal Article] Nutrient control of phosphorylation and translocation of Foxo1 in C57BL/6 and db/db mice2006
- Author(s)
  Daitoku, H. et al.
- Journal Title
  
  Int.J.Mol.Med. (印刷中)
- Data Source
  KAKENHI-PROJECT-16780230
[Journal Article] The LXXLL motif of murine forkhead transcription factor FoxOl mediates Sirtl-dependent transcriptional activity.2006
- Author(s)
  Nakae, J., Cao, Y., Daitoku, H., Fukamizu, A., Ogawa, W., Yano, Y., Hayashi, Y.
- Journal Title
  
  J.Clin.Invest. 116
  
  Pages: 2473-2483
- Data Source
  KAKENHI-PROJECT-18780249
[Journal Article] Smad3 is acetylated by p300/CBP to regulate its transactivation activity.2006
- Author(s)
  Inoue Y, Itoh Y, Abe K, Okamoto T, Daitoku H, Fukamizu, A, Onozaki K, Hayashi H.
- Journal Title
  
  Oncogene 26
  
  Pages: 500-508
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17054004
[Journal Article] Nutrient control of phosphorylation and translocation of Foxo1 in C57BL/6 and db/db mice.2006
- Author(s)
  Aoyama H, Daitoku H, Fukamizu, A.
- Journal Title
  
  Int. J. Mol. Med. 18
  
  Pages: 433-439
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17054004
[Journal Article] Mitogen-activated protein kinases, Erk and p38, phosphorylate and regulate Foxol.2006
- Author(s)
  Asada, S., Daitoku, H., Matsuzaki, H., Saito, T., Sudo, T., Mukai, H., Iwashita, S., Kako, K., Kishi, T., Kasuya, Y., Fukamizu, A.
- Journal Title
  
  Cell.Signal. 3
  
  Pages: 519-527
- Data Source
  KAKENHI-PROJECT-18780249
[Journal Article] Nutrient control of phosphorylation and translocation of Foxol in C57BL/6 and db/db mice.2006
- Author(s)
  Aoyama, H., Daitoku, H., Fukamizu, A.
- Journal Title
  
  Int.J.Mol.Med. 3
  
  Pages: 433-439
- Data Source
  KAKENHI-PROJECT-18780249
[Journal Article] Smad3 is acetylated by p300/CBP to regulate its transactivation activity.2006
- Author(s)
  Inouc, Y., Itoh, Y., Abe, K., Okamoto, T., Daitoku, H., Fukamizu, A., Onozaki, K., Hayashi, H.
- Journal Title
  
  Oncogene 26
  
  Pages: 500-508
- Data Source
  KAKENHI-PROJECT-18780249
[Journal Article] Acetylation of Foxo1 alters its DNA-binding ability and sensitivity to phosphorylation2005
- Author(s)
  Daitoku, H. et al.
- Journal Title
  
  Proc.Natl.Acad.Sci.USA 102
  
  Pages: 11278-11283
- Data Source
  KAKENHI-PROJECT-16780230
[Journal Article] Acetylation of Foxo1 alters its DNA-binding ability and sensitivity to phosphorylation.2005
- Author(s)
  Matsuzaki H, Daitoku H, Hatta M, Aoyama H, Yoshimochi K, Fukamizu A.
- Journal Title
  
  Proc. Natl. Acad. Sci. 102
  
  Pages: 11278-11283
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17054004
[Journal Article] Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity2004
- Author(s)
  Daitoku, H. et al.
- Journal Title
  
  Proc.Natl.Acad.Sci.USA 101
  
  Pages: 10042-10047
- Data Source
  KAKENHI-PROJECT-16780230
[Journal Article] Bile acids regulate gluconeogenic gene expression via SHP-mediated repression of HNF-4 and Foxo12004
- Author(s)
  Daitoku, H. et al.
- Journal Title
  
  J.Biol.Chem. 279
  
  Pages: 23158-23165
- Data Source
  KAKENHI-PROJECT-16780230
[Presentation] ヒスチジンNτ-メチル化修飾の新規基質γ-enolaseの同定2023
- Author(s)
  笠井郁也、加香孝一郎、丸橋俊介、大徳浩照、深水昭吉
- Organizer
  第46回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-20H02947
[Presentation] 質量分析による哺乳類ヒストンのヒスチジンメチル化修飾の同定2023
- Author(s)
  林岳宏、大徳浩照、加香孝一郎、深水昭吉
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20H02947
[Presentation] ヒスチジンメチル化酵素METTL9は糖鎖修飾を受けて細胞化に分泌される2023
- Author(s)
  池田音緒、大徳浩照、関口直希、加香孝一郎、深水昭吉
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20H02947
[Presentation] ヒスチジンメチル化酵素METTL9における糖鎖修飾と細胞外分泌の役割2023
- Author(s)
  池田音緒、大徳浩照、関口直希、加香孝一郎、深水昭吉
- Organizer
  2023年度日本生化学会関東支部例会
- Data Source
  KAKENHI-PROJECT-20H02947
[Presentation] Protein histidine methylation: An old and new post-translational modification2023
- Author(s)
  Hiroaki Daitoku
- Organizer
  8th Meeting of the Asian Forum for Chromosome and Chromatin Biology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H02947
[Presentation] ヒスチジンメチル化酵素METTL9のN結合型糖鎖修飾とその役割の検討2022
- Author(s)
  関口直希、大徳浩照、加香孝一郎、深水昭吉
- Organizer
  2022年度日本生化学会関東支部例会
- Data Source
  KAKENHI-PROJECT-20H02947
[Presentation] ヒスチジンメチル化酵素METTL9のN結合型糖鎖修飾と細胞外分泌の解析2022
- Author(s)
  関口直希、大徳浩照、池田音緒、加香孝一郎、深水昭吉
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20H02947
[Presentation] ウシ胸腺ヒストンを用いたヒスチジンメチル化修飾部位の同定2022
- Author(s)
  林岳宏、大徳浩照、加香孝一郎、深水昭吉
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20H02947
[Presentation] LC-MS/MS を用いたアミノ酸解析によるヒストンヒスチジンメチル化修飾の検証2022
- Author(s)
  林岳宏、大徳浩照、加香孝一郎、加藤薫、丸橋春介、深水昭吉
- Organizer
  2022年度日本生化学会関東支部例会
- Data Source
  KAKENHI-PROJECT-20H02947
[Presentation] siRNAスクリーニングによる新規ヒスチジンメチル基転移酵素の探索2021
- Author(s)
  染谷百香、大徳浩照、加香孝一郎、深水昭吉
- Organizer
  第94回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20H02947
[Presentation] 線虫の新規ヒスチジンメチル化酵素METL-18の自己メチル化と生物学的意義の解析2021
- Author(s)
  春木陽香理、大徳浩照、田島達也、加香孝一郎、深水昭吉
- Organizer
  第94回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20H02947
[Presentation] METTL9はS100A9を基質とするヒスチジンNπ型のヒスチジンメチル化酵素である2021
- Author(s)
  大徳浩照、染谷百香、加香孝一郎、関口直希、深水昭吉
- Organizer
  第94回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20H02947
[Presentation] ヒストン球状ドメインにおけるメチル化修飾の解析2021
- Author(s)
  林岳宏、大徳浩照、加香孝一郎、植竹徹、深水昭吉
- Organizer
  第94回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20H02947
[Presentation] Nπヒスチジンメチル化酵素METTL9の糖鎖修飾とその役割の解析2021
- Author(s)
  関口直希、大徳浩照、染谷百香、加香孝一郎、深水昭吉
- Organizer
  第94回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20H02947
[Presentation] 線虫の新規ヒスチジンメチル化酵素METL-18の自己メチル化と生物学的意義の解析2020
- Author(s)
  春木陽香理, 大徳浩照, 田島達也, 加香孝一郎, 深水昭吉
- Organizer
  第93回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20H02947
[Presentation] siRNAスクリーニングによる新規ヒスチジンメチル基転移酵素の探索2020
- Author(s)
  染谷百香, 大徳浩照, 加香孝一郎, 深水昭吉
- Organizer
  第93回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20H02947
[Presentation] Molecular function and biological significance of protein histidine methyltransferase METL-18 in C. elegans2020
- Author(s)
  大徳浩照、田島達也、春木陽香理、染谷百香、加香孝一郎、深水昭吉
- Organizer
  第43回日本分子生物学会大会
- Data Source
  KAKENHI-PROJECT-20H02947
[Presentation] 線虫における新規ヒスチジンメチル化酵素METL-18の機能解析2020
- Author(s)
  大徳浩照、田島達也、春木陽香理、染谷百香、加香孝一郎、深水昭吉
- Organizer
  第93回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20H02947
[Presentation] in vivoスクリーニング系による新規ヒスチジンメチル基転移酵素の探索2019
- Author(s)
  林岳宏、大徳浩照、中島実咲、染谷百香、春木陽香理、田島達也、加香孝一郎、深水昭吉
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-17K08193
[Presentation] 線虫ヒストンにおける新規ヒスチジンメチル基転移酵素の探索2019
- Author(s)
  林岳宏、大徳浩照、中島実咲、加香孝一郎、深水昭吉
- Organizer
  2019年度日本生化学会関東支部例会
- Data Source
  KAKENHI-PROJECT-17K08193
[Presentation] 線虫 C. elegansにおける開始メチオニンtRNA m1A58修飾が寿命に及ぼす影響2018
- Author(s)
  宮田真衣、大徳浩照、角直亮、横山航、廣田恵子、深水昭吉
- Organizer
  2018年度日本生化学会関東支部例会
- Data Source
  KAKENHI-PROJECT-17K08193
[Presentation] 線虫 C. elegans のリボソームに対するヒスチジンメチル基転移酵素hpm-1の役割2018
- Author(s)
  中島実咲、大徳浩照、狩野明彦、廣田恵子、深水昭吉
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-17K08193
[Presentation] 線虫 C. elegansにおける開始メチオニンtRNA m1A58修飾を介した寿命制御機構の解析2018
- Author(s)
  大徳浩照、宮田真衣、角直亮、横山航、廣田恵子、深水昭吉
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-17K08193
[Presentation] RNAメチル化修飾による寿命制御メカニズム2018
- Author(s)
  大徳浩照、廣田恵子、宮田真衣、角直亮、深水昭吉
- Organizer
  第72回日本栄養・食糧学会
- Invited
- Data Source
  KAKENHI-PROJECT-17K08193
[Presentation] 線虫C. elegansにおける転写因子DAF-16の活性化に働く熱センサーの同定2017
- Author(s)
  新生翔、大徳浩照、金子悠太、深水昭吉
- Organizer
  生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-17K08193
[Presentation] 転写因子FOXO1/DAF-16の高グルコースに応答したアセチル化制御機構2016
- Author(s)
  大徳浩照、小沼久里子、平田優介、坂井愛理、稲川貴之、深水昭吉
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  東北大学（宮城県・仙台市）
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-26450500
[Presentation] S期の紫外線DNA損傷応答におけるフォークヘッド型転写因子FOXO1/DAF-16の役割2016
- Author(s)
  金子悠太、大徳浩照、深水昭吉
- Organizer
  冬の若手ワークショップ
- Place of Presentation
  山中湖　ホテル清渓（山梨県山中湖村）
- Year and Date
  2016-02-05
- Data Source
  KAKENHI-PROJECT-26450500
[Presentation] S期の紫外線DNA損傷応答におけるフォークヘッド型転写因子FOXO1/DAF-16の役割2016
- Author(s)
  金子　悠太、大徳　浩照、深水　昭吉
- Organizer
  「転写代謝システム」冬の若手ワークショップ
- Place of Presentation
  山梨県山中湖村　ホテル清渓
- Year and Date
  2016-02-05
- Data Source
  KAKENHI-PLANNED-23116004
[Presentation] 線虫を用いた転写因子FOXO1の翻訳後修飾制御機構のin vivo解析2016
- Author(s)
  大徳浩照、小沼久里子、平田優介、新生翔、深水昭吉
- Organizer
  Front Runner of Future Diabetes Research第５回研究発表会
- Place of Presentation
  ホテル椿山荘東京（東京都・文京区）
- Year and Date
  2016-07-23
- Data Source
  KAKENHI-PROJECT-26450500
[Presentation] ゲノム編集技術を用いた転写因子DAF-16の寿命制御機構の解明2016
- Author(s)
  新生　翔、大徳　浩照、深水　昭吉
- Organizer
  「転写代謝システム」冬の若手ワークショップ
- Place of Presentation
  山梨県山中湖村　ホテル清渓
- Year and Date
  2016-02-05
- Data Source
  KAKENHI-PLANNED-23116004
[Presentation] ゲノム編集技術を用いた転写因子DAF-16の寿命制御機構の解明2016
- Author(s)
  新生翔、大徳浩照、深水昭吉
- Organizer
  冬の若手ワークショップ
- Place of Presentation
  山中湖　ホテル清渓（山梨県山中湖村）
- Year and Date
  2016-02-05
- Data Source
  KAKENHI-PROJECT-26450500
[Presentation] 長寿転写因子FOXO1/DAF-16のDNA損傷応答メカニズム2015
- Author(s)
  大徳浩照、深水昭吉
- Organizer
  BMB2015
- Place of Presentation
  神戸ポートピアホテル（兵庫県神戸市）
- Year and Date
  2015-12-04
- Data Source
  KAKENHI-PROJECT-26450500
[Presentation] 紫外線DNA損傷応答におけるフォークヘッド型転写因子FOXO1/DAF-16の役割2015
- Author(s)
  金子悠太, 大徳浩照, 吉用賢治, 松本佳保里, 米野千尋, 深水昭吉
- Organizer
  冬の若手ワークショップ 2015
- Place of Presentation
  群馬県渋川市　ホテル松本楼
- Year and Date
  2015-02-05
- Data Source
  KAKENHI-PLANNED-23116004
[Presentation] 長寿転写因子FOXO1/DAF-16のDNA損傷応答メカニズム2015
- Author(s)
  大徳　浩照
- Organizer
  第38回分子生物学会年会・第88回生化学会大会合同大会
- Place of Presentation
  兵庫県神戸市　神戸ポートアイランド
- Year and Date
  2015-12-04
- Data Source
  KAKENHI-PLANNED-23116004
[Presentation] 転写因子FOXO1/DAF-16のグルコースに応答したアセチル化制御機構の解析2015
- Author(s)
  小沼　久里子、大徳　浩照、平田　優介、金子　悠太、Toth, E.、有本　光江、加香　孝一郎、深水　昭吉
- Organizer
  第38回分子生物学会年会・第88回生化学会大会合同大会
- Place of Presentation
  兵庫県神戸市　神戸ポートアイランド
- Year and Date
  2015-12-03
- Data Source
  KAKENHI-PLANNED-23116004
[Presentation] 長寿変異体における転写因子DAF-16の転写活性化能の評価2015
- Author(s)
  新生翔, 大徳浩照, 金子悠太, 廣田恵子, 深水昭吉
- Organizer
  冬の若手ワークショップ 2015
- Place of Presentation
  ホテル松本楼（群馬県渋川市伊香保町）
- Year and Date
  2015-02-06
- Data Source
  KAKENHI-PROJECT-26450500
[Presentation] 線虫におけるCRISPR/cas9ゲノム編集技術を用いた転写因子DAF-16の転写活性化能欠失変異体の樹立2015
- Author(s)
  新生翔、大徳浩照、深水昭吉
- Organizer
  BMB2015
- Place of Presentation
  神戸国際展示場（兵庫県神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26450500
[Presentation] 長寿転写因子FOXO1/DAF-16のグルコースに応答したアセチル化制御機構の解析2015
- Author(s)
  小沼久里子、大徳浩照、深水昭吉
- Organizer
  BMB2015
- Place of Presentation
  神戸国際展示場（兵庫県神戸市）
- Year and Date
  2015-12-04
- Data Source
  KAKENHI-PROJECT-26450500
[Presentation] 長寿転写因子FOXO1/DAF-16のグルコースに応答したアセチル化制御機構の解析2015
- Author(s)
  小沼　久里子、大徳　浩照、深水　昭吉
- Organizer
  第38回分子生物学会年会・第88回生化学会大会合同大会
- Place of Presentation
  兵庫県神戸市　神戸ポートアイランド
- Year and Date
  2015-12-04
- Data Source
  KAKENHI-PLANNED-23116004
[Presentation] A UPLC-based quantitative method for measuring asymmetric dimethylarginine in cellular proteins2015
- Author(s)
  沙亮，加香孝一郎，大徳浩照，深水昭吉
- Organizer
  冬の若手ワークショップ 2015
- Place of Presentation
  群馬県渋川市　ホテル松本楼
- Year and Date
  2015-02-06
- Data Source
  KAKENHI-PLANNED-23116004
[Presentation] 線虫におけるCRISPR/cas9ゲノム編集技術を用いた転写因子DAF-16の転写活性化能欠失変異体の樹立2015
- Author(s)
  新生　翔、大徳　浩照、深水　昭吉
- Organizer
  第38回分子生物学会年会・第88回生化学会大会合同大会
- Place of Presentation
  兵庫県神戸市　神戸ポートアイランド
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PLANNED-23116004
[Presentation] 長寿変異体における転写因子DAF-16の転写活性化能の評価2015
- Author(s)
  新生翔, 大徳浩照, 金子悠太, 廣田恵子, 深水昭吉
- Organizer
  冬の若手ワークショップ 2015
- Place of Presentation
  群馬県渋川市　ホテル松本楼
- Year and Date
  2015-02-06
- Data Source
  KAKENHI-PLANNED-23116004
[Presentation] 食餌性メチオニン制限がメチオニン量及び S-adenosyl-L-methionine量へ与える影響2015
- Author(s)
  山内理恵子、廣田恵子、徐照、加香孝一郎、大徳浩照、深水昭吉
- Organizer
  冬の若手ワークショップ 2015
- Place of Presentation
  群馬県渋川市　ホテル松本楼
- Year and Date
  2015-02-06
- Data Source
  KAKENHI-PLANNED-23116004
[Presentation] 食餌性メチオニン制限によるメチオニン及び S-adenosyl-L-methionine への影響2014
- Author(s)
  山内理恵子、廣田恵子、徐照、飯塚慧、大徳浩照、加香孝一郎、深水昭吉
- Organizer
  平成26年度転写代謝システム領域班会議
- Place of Presentation
  宮城県仙台市　岩沼屋
- Year and Date
  2014-07-12
- Data Source
  KAKENHI-PLANNED-23116004
[Presentation] 紫外線DNA損傷応答におけるフォークヘッド型転写因子FOXO1/DAF-16の役割2014
- Author(s)
  金子悠太, 大徳浩照, 吉用賢治, 松本佳保里, 米野千尋, 深水昭吉
- Organizer
  第87回日本生化学会年会
- Place of Presentation
  京都府京都市　京都国際会議場
- Year and Date
  2014-10-17
- Data Source
  KAKENHI-PLANNED-23116004
[Presentation] Elucidation of regulation of longevity transcription factor DAF-16 in vivo2014
- Author(s)
  米野千尋, 新生翔, 大徳浩照, 金子悠太, 深水昭吉
- Organizer
  平成26年度転写代謝システム領域班会議
- Place of Presentation
  宮城県仙台市　岩沼屋
- Year and Date
  2014-07-12
- Data Source
  KAKENHI-PLANNED-23116004
[Presentation] 長寿転写因子DAF-16のin vivoにおける制御機構の解明2014
- Author(s)
  米野千尋, 新生翔, 大徳浩照, 金子悠太, 深水昭吉
- Organizer
  第87回日本生化学会年会
- Place of Presentation
  京都府京都市　京都国際会議場
- Year and Date
  2014-10-17
- Data Source
  KAKENHI-PLANNED-23116004
[Presentation] アコニターゼ2はEGFシグナル経路を介してα-チューブリンのアセチル化レベルを制御する2014
- Author(s)
  柴沼香穂, 大徳浩照, 加香孝一郎, 金子悠太, 深水昭吉
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  神奈川県横浜市　パシフィコ横浜
- Year and Date
  2014-11-27
- Data Source
  KAKENHI-PLANNED-23116004
[Presentation] Dietary methionine restriction in axenic medium decreases both methionine and S-adenosyl-L-methionine levels. 6th Asia-pacific C.elegans Meeting2014
- Author(s)
  Yamauchi, R., Hirota, K., Xu, Z., Iizuka, K., Daitoku, H., Kako, K., Fukamizu, A.
- Organizer
  6th Asia-pacific C.elegans Meeting
- Place of Presentation
  奈良県奈良市　奈良県新公会堂
- Year and Date
  2014-07-15
- Data Source
  KAKENHI-PLANNED-23116004
[Presentation] 紫外線DNA損傷応答におけるフォークヘッド型転写因子FOXO1/DAF-16の役割2014
- Author(s)
  金子悠太, 大徳浩照, 吉用賢治, 松本佳保里, 米野千尋, 深水昭吉
- Organizer
  第87回日本生化学会年会
- Place of Presentation
  京都国際会館（京都市左京区）
- Year and Date
  2014-10-17
- Data Source
  KAKENHI-PROJECT-26450500
[Presentation] 長寿転写因子DAF-16のin vivoにおける制御機構の解明2014
- Author(s)
  米野千尋, 新生翔, 大徳浩照, 金子悠太, 深水昭吉
- Organizer
  第87回日本生化学会年会
- Place of Presentation
  京都国際会館（京都市左京区）
- Year and Date
  2014-10-17
- Data Source
  KAKENHI-PROJECT-26450500
[Presentation] 線虫C.elegansにおける転写因子DAF-16の新たな活性評価系の確立2014
- Author(s)
  新生翔、大徳浩照、金子悠太、廣田恵子、深水昭吉
- Organizer
  新学術領域「転写代謝システム」冬の若手ワークショップ
- Place of Presentation
  群馬 (舌切雀のお宿　磯部ガーデン)
- Data Source
  KAKENHI-PLANNED-23116004
[Presentation] 線虫C.elegansを用いたSAM量を制御するメチル化酵素の同定2014
- Author(s)
  小島真梨子、廣田恵子、加香孝一郎、大徳浩照、深水昭吉
- Organizer
  新学術領域「転写代謝システム」冬の若手ワークショップ
- Place of Presentation
  群馬 (舌切雀のお宿　磯部ガーデン)
- Data Source
  KAKENHI-PLANNED-23116004
[Presentation] 線虫C.elegansにおける短期絶食による寿命延長メカニズムの解析2014
- Author(s)
  作田元気、廣田恵子、加香孝一郎、大徳浩照、深水昭吉
- Organizer
  新学術領域「転写代謝システム」冬の若手ワークショップ
- Place of Presentation
  群馬 (舌切雀のお宿　磯部ガーデン)
- Data Source
  KAKENHI-PLANNED-23116004
[Presentation] Identification of methyltransferases responsible for regulating the S-adenosylmethionine (SAM) levels in Caenorhabditis elegans.2013
- Author(s)
  Kojima, M., Hirota, K., Kako, K., Daitoku, H. and Fukamizu, A.
- Organizer
  兵庫（淡路夢舞台国際会議場）
- Place of Presentation
  兵庫（淡路夢舞台国際会議場）
- Data Source
  KAKENHI-PLANNED-23116004
[Presentation] S-adenosyl-L-methionine synthetase-1 (SAMS-1) regulates short-term-starvation-induced lifespan extension in Caenorhabditis elegans2013
- Author(s)
  Sakuta, G., Hirota, K., Takahashi, Y., Daitoku, H. Kako, K. and Fukamizu, A.
- Organizer
  International Symposium on Transcription and Metabolism
- Place of Presentation
  兵庫（淡路夢舞台国際会議場）
- Data Source
  KAKENHI-PLANNED-23116004
[Presentation] 転写因子FOXO1は紫外線DNA損傷応答に関与する2013
- Author(s)
  金子悠太、大徳浩照、深水昭吉
- Organizer
  若手ワークショップ@鬼怒川
- Place of Presentation
  栃木県日光市
- Year and Date
  2013-01-24
- Data Source
  KAKENHI-PROJECT-22688029
[Presentation] Functional analysis for histidine protein methyltransferase in Caenorhabditis elegans.2013
- Author(s)
  Ishihara, S., Hirota, K., Kako, K., Tanaka, Y., Daitoku, H. Takahashi, Y. and Fukamizu, A.
- Organizer
  International Symposium on Transcription and Metabolism
- Place of Presentation
  兵庫（淡路夢舞台国際会議場）
- Data Source
  KAKENHI-PLANNED-23116004
[Presentation] 転写因子Foxo1は紫外線DNA損傷応答に関与する2012
- Author(s)
  金子悠太、大徳浩照、深水昭吉
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡国際会議場
- Year and Date
  2012-12-11
- Data Source
  KAKENHI-PROJECT-22688029
[Presentation] 糖代謝調節における転写因子のクロストークとアルギニンメチル化制御2011
- Author(s)
  大徳浩照
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜(招待講演)
- Year and Date
  2011-09-23
- Data Source
  KAKENHI-PROJECT-22688029
[Presentation] フォークヘッド転写因子DAF-16は線虫の損傷乗り越え複製に関与する2011
- Author(s)
  松本佳保里、大徳浩照、深水昭吉
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2011-12-14
- Data Source
  KAKENHI-PROJECT-22688029
[Presentation] 転写因子Foxo1は紫外線DNA損傷応答に関与する2011
- Author(s)
  金子悠太、大徳浩照、深水昭吉
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2011-12-14
- Data Source
  KAKENHI-PROJECT-22688029
[Presentation] アルギニンメチル化とAktリン酸化のクロストークは寿命制御に関与する2011
- Author(s)
  大徳浩照
- Organizer
  転写研究会若手シンポジウム
- Place of Presentation
  東北大学東京分室会議室
- Year and Date
  2011-02-18
- Data Source
  KAKENHI-PROJECT-22688029
[Presentation] DNA damage control by FOXO1 in response to UV irradiation2009
- Author(s)
  Daitoku H, Yoshimochi K, Fukamizu A.
- Organizer
  第24回内藤コンファレンス「細胞核ダイナミクスとRNA [II]」
- Place of Presentation
  札幌
- Year and Date
  2009-06-25
- Data Source
  KAKENHI-PROJECT-20780237
[Presentation] アルギニンメチル化による転写因子FOXO1の機能制御機構2009
- Author(s)
  大徳浩照
- Organizer
  平成21年度日本生化学会関東支部例会
- Place of Presentation
  つくば国際会議場
- Year and Date
  2009-06-20
- Data Source
  KAKENHI-PROJECT-20780237
[Presentation] アルギニンメチル化による転写因子FOXO1の機能制御機構2009
- Author(s)
  大徳浩昭
- Organizer
  (社)日本生化学会関東支部例会「若手が担う次世代型生化学研究」
- Place of Presentation
  つくば
- Year and Date
  2009-06-20
- Data Source
  KAKENHI-PROJECT-17054004
[Presentation] アルギニンメチル化による転写因子FOXO1の機能制御機構2009
- Author(s)
  大徳浩照
- Organizer
  日本生化学会関東支部例会
- Place of Presentation
  つくば
- Year and Date
  2009-06-20
- Data Source
  KAKENHI-PROJECT-20780237
[Presentation] Crosstalk regulation of arginine methylation and Akt-induced phosphorylation2009
- Author(s)
  大徳浩照
- Organizer
  第82回日本生化学会大会シンポジウム
- Place of Presentation
  神戸ポートピアホテル
- Year and Date
  2009-10-21
- Data Source
  KAKENHI-PROJECT-20780237
[Presentation] Crosstalk regulation of arginine methylation and Akt-induced phosphorylation2009
- Author(s)
  Daitoku H, Yamagata K, Takahashi Y, Sakamaki JI, Fukamizu A.
- Organizer
  第82回日本生化学会大会シンポジウム
- Place of Presentation
  神戸
- Year and Date
  2009-10-21
- Data Source
  KAKENHI-PROJECT-20780237
[Presentation] リジンメチル化酵素SET9によるFoxol制御機構の解析2008
- Author(s)
  圓谷美香・村山典子・大徳浩照・深水昭吉
- Organizer
  08'遺伝情報DECODE・冬のワークショップ
- Place of Presentation
  越後湯沢
- Year and Date
  2008-01-22
- Data Source
  KAKENHI-PROJECT-17054004
[Presentation] アルギニンメチル化による転写因子FOXO1のリン酸化阻害機構の解明回2008
- Author(s)
  大徳浩照
- Organizer
  第12回日本心血管内分泌代謝学会学術総会
- Place of Presentation
  熊本市国際交流会館
- Year and Date
  2008-11-28
- Data Source
  KAKENHI-PROJECT-20780237
[Presentation] Arginine methylation of FOXO1 inhiubits Akt-dependent phosphorylation2008
- Author(s)
  山形一行・大徳浩照・高橋悠太・久武幸司・加香孝一郎・向井秀仁・深水昭吉
- Organizer
  08'遺伝情報DECODE・冬のワークショップ
- Place of Presentation
  越後湯沢
- Year and Date
  2008-01-22
- Data Source
  KAKENHI-PROJECT-17054004
[Presentation] Regulation of Foxo family by arginine methylation in response to oxidative stress2008
- Author(s)
  Daitoku H, Yamagata K, Fukamizu A.
- Organizer
  Biochemistry and Molecular Biology (BMB2008)シンポジウム
- Place of Presentation
  神戸
- Year and Date
  2008-12-12
- Data Source
  KAKENHI-PROJECT-20780237
[Presentation] PRMT 1によるFOXO 1のアルギニンメチル化はAkt依存的なリン酸化を阻害する2008
- Author(s)
  大徳, 浩照
- Organizer
  第2回炎症・脂質代謝・メタボリサーチフォーラム
- Place of Presentation
  東京大学医学部教育研究棟14階鉄門記念講堂
- Year and Date
  2008-03-15
- Data Source
  KAKENHI-PROJECT-18780249
[Presentation] アルギニンメチル化による転写因子FOXO1のリン酸化阻害機構の解明2008
- Author(s)
  大徳浩照
- Organizer
  第12回日本心血管内分泌代謝学会学術総会
- Place of Presentation
  熊本
- Year and Date
  2008-11-28
- Data Source
  KAKENHI-PROJECT-17054004
[Presentation] Caenorhabditis elegansにおける転写因子DAF-16のアルギニンメチル化酵素による制御機構の解明2008
- Author(s)
  高橋悠太・大徳浩照・山形一行・廣田恵子・石井直明・深水昭吉
- Organizer
  08'遺伝情報DECODE・冬のワークショップ
- Place of Presentation
  越後湯沢
- Year and Date
  2008-01-22
- Data Source
  KAKENHI-PROJECT-17054004
[Presentation] ポリ(ADP-リポシル)化による転写因子FOXO1の制御機構の解析2008
- Author(s)
  坂巻純一・大徳浩照・吉用賢治・益谷美都子・三輪正直・深水昭吉
- Organizer
  08'遺伝情報DECODE・冬のワークショップ
- Place of Presentation
  越後湯沢
- Year and Date
  2008-01-22
- Data Source
  KAKENHI-PROJECT-17054004
[Presentation] 転写因子FOXO1のDNA修複における機能的役割の解析2008
- Author(s)
  吉用賢治・大徳浩照・深水昭吉
- Organizer
  08'遺伝情報DECODE・冬のワークショップ
- Place of Presentation
  越後湯沢
- Year and Date
  2008-01-22
- Data Source
  KAKENHI-PROJECT-17054004
[Presentation] Regulation of FOXO family by arginine methylation in response to oxidative stress2008
- Author(s)
  大徳浩照
- Organizer
  第31回日本分子生物学会年会第81回日本生化学会大会合同大会
- Place of Presentation
  神戸国際会議場1階メインホール
- Year and Date
  2008-12-12
- Data Source
  KAKENHI-PROJECT-20780237
[Presentation] Arginine methylation of FOXO1 inhiubits Akt-dependent phosphorylation2007
- Author(s)
  山形一行・大徳浩照・高橋悠太・久武幸司・加香孝一郎・向井秀仁・深水昭吉
- Organizer
  日本分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2007-12-12
- Data Source
  KAKENHI-PROJECT-17054004
[Presentation] FOXOのアルギニンメチル修飾はAKt依存的なりン酸化を阻害する2007
- Author(s)
  山形一行・大徳浩照・高橋悠太・久武幸司・加香孝一郎・向井秀仁・深水昭吉
- Organizer
  日本心血管内分泌謝学会
- Place of Presentation
  東京
- Year and Date
  2007-11-17
- Data Source
  KAKENHI-PROJECT-17054004
[Presentation] Arginine methylation of FOXO1 inhiubits Akt-dependent phosphorylation2007
- Author(s)
  山形一行・大徳浩照・高橋悠太・久武幸司・加香孝一郎・向井秀仁・深水昭吉
- Organizer
  JST-ERATO山本環境応答プロジェクトシンポジウム
- Place of Presentation
  つくば
- Year and Date
  2007-12-21
- Data Source
  KAKENHI-PROJECT-17054004
[Presentation] 糖代謝調節における転写因子のクロストークとアルギニンメチル化制御
- Author(s)
  大徳浩照
- Organizer
  第84回日本生化学学会大会
- Place of Presentation
  京都国際会館
- Data Source
  KAKENHI-PLANNED-23116004
[Presentation] SAM代謝とメチル基転移酵素
- Author(s)
  深水昭吉，廣田恵子，大徳浩照，加香孝一郎
- Organizer
  平成26年度転写代謝システム領域班会議
- Place of Presentation
  宮城県仙台市　岩沼屋
- Year and Date
  2014-07-11 – 2014-07-13
- Data Source
  KAKENHI-PLANNED-23116004

1. FUKAMIZU Akiyoshi (60199172)

# of Collaborated Projects: 3 results

# of Collaborated Products: 52 results
2. HIROTA Keiko (00375370)

# of Collaborated Projects: 2 results

# of Collaborated Products: 13 results
3. TANIMOTO Keiji (90261776)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. KAKOU Kouichirou (60311594)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
5. ISHIDA Junji (30323257)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. TAKAHASHI Hidekazu (90450402)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. 金俊達

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Daitoku Hiroaki 大徳 浩照

DAITOKU Hiroaki 大徳 浩照

Research Projects

Research Products

Co-Researchers

細胞外環境におけるタンパク質メチル化酵素の生物学的役割の解明Principal Investigator

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Elucidation of the regulatory mechanism and biological significance of histidine methyltransferase METTL9Principal Investigator

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Relationship between glucose metabolism and FOXO1 acetylation through acetyl-CoAPrincipal Investigator

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In vivo analysis of longevity mechanism of transcription factor DAF-16/FOXOPrincipal Investigator

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Crosstalk of transcriptional status and amino acid metabolism

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Functional analysis of DNA damage response of transcription factor FOXO1 in lifespan regulationPrincipal Investigator

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Analysis for regulation of transcription factor FOXO1 by post-translational modification and mechanism of determination of lifspanPrincipal Investigator

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代謝と寿命をつなぐ転写因子FOXO1の多重修飾制御機構の解明Principal Investigator

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Elucidation of DECODE cycle that regulates homeostasis mediated by protein modification.

Principal Investigator

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Feto-maternal network on pregnancy-induced hypertension

Principal Investigator

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転写因子Foxolの多重修飾制御機構に関する研究Principal Investigator

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Research Field

Research Institution

[Book] 栄養・代謝物シグナルと食品機能2022

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Book] エッセンシャル栄養化学2021

Author(s)

Total Pages

Daitoku Hiroaki 大徳浩照

DAITOKU Hiroaki 大徳浩照

[Book] 実験医学　特集 RNAが修飾される2018